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Strain Name:

B6.129P-Cx3cr1tm1Litt/J

Stock Number:

005582

Availability:

Repository- Live

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General Terms and Conditions
Additional Licensing and Use Restrictions

Genes & Alleles   Cx3cr1;   Cx3cr1tm1Litt;   GFP;

Product Information

Strain Details

Type JAX® GEMM® Strain - Congenic
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Mutant Strain
Type JAX® GEMM® Strain - Targeted Mutation
Mating SystemHomozygote x Homozygote         (Female x Male)
Specieslaboratory mouse
Donating Investigator Dan Littman,   New York University Medical Center
GenerationN10+N1F6 (08-JAN-08)

Strain Description
Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. RT-PCR analysis of lymphoid tissue from homozygotes detects mutant gene product (mRNA) and no wild type gene product (mRNA). Flow cytometric analysis of peripheral blood cells identified a subset of green fluorescent cells not observed in wild type mice. Enhanced Green Fluorescent Protein (EGFP), but not the endogenous gene, is expressed in monocytes, dendritic cells, NK cells, and brain microglia, mimicking endogenous gene expression. The same subset of peripheral blood cells isolated from heterozygote mice express detectable levels of EGFP. Immunohistochemical analysis of spleen and peripheral nerve tissue from homozygotes does not detect EGFP. This mutant mouse strain may be useful in studies of leukocyte migration and trafficking.

Strain Development
A targeting vector containing an Enhanced Green Fluorescent Protein (EGFP, Clontech) cDNA sequence, loxP-flanked neomycin resistance gene, herpes simplex virus thymidine kinase gene, and SV40 polyadenylation site sequence was used to disrupt the first 390 bp of exon 2. The construct was electroporated into 129P2/OlaHsd derived E14.1 embryonic stem (ES) cells which were transiently transfected with a Cre recombinase vector to remove the selection cassette. ES cells that had successfully undergone Cre-mediated recombination (removing the loxP-flanked neo cassette and leaving a single loxP site downstream of EGFP) were injected into recipient blastocysts. The resulting chimeric animals were backcrossed to C57BL/6J for 10 generations before being made homozygous.

Mammalian Phenotype Terms assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Cx3cr1tm1Litt/Cx3cr1tm1Litt

        involves: 129P2/OlaHsd * C57BL/6
  • immune system phenotype
  • *normal* immune system phenotype (J:84544)
    • normal dendritic cell migration and IL-12 production in response to a microbial antigen (STAg)
    • normal Langerhans cell migration and APC function in response to contact sensitizer (oxazolone)
  • nervous system phenotype
  • *normal* nervous system phenotype (J:84544)
    • normal neuronal-glial cross talk indicated by microglial response to peripheral nerve injury, 129P2/OlaHsd and C57BL/6 mixed genetic background

Cx3cr1tm1Litt/Cx3cr1tm1Litt

        C.129P2-Cx3cr1tm1Litt
  • immune system phenotype
  • *normal* immune system phenotype (J:84544)
    • normal monocyte extravasation and subsequent differentiation into macrophages in response to intraperitoneal injection of thioglycolate, a model of acute peritonitis

Gene & Allele Details

Allele Symbol Cx3cr1tm1Litt
Allele Name targeted mutation 1, Dan R Littman
Common Name(s) CX3CR1-GFP; CX3CR1GFP;
Mutation Made By Steffen Jung,   Weizmann Institute of Science
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14.1
ES Cell Line Strain129P2/OlaHsd
Expressed Gene GFP, Green Fluorescent Protein, jellyfish
Green Fluorescent Protein (GFP), derived from the jellyfish Aequorea victoria, is a versatile reporter molecule which has found use in many biological applications. The original molecule has been modified in order to enhance its fluorescence intensity (EGFP, enhanced GFP). When utilized in a transgenic construct, tissue expressing sufficient amounts of GFP will fluoresce when exposed to a 488 nm light source.
Gene Symbol and Name Cx3cr1, chemokine (C-X3-C) receptor 1
Chromosome 9
Gene Common Name(s) CCRL1; CMKBRL1; CMKDR1; GPR13; GPRV28; Rbs11; V28;
Molecular Note The endogenous locus was disrupted by the insertion of sequence encoding green fluourescent protein (GFP), replacing the first 390 bp of the coding exon (exon 2). The deleted region encoded an amino-terminal portion of the protein that is crucial for interaction with endogenous ligand, Cx3cl1. A floxed neo gene included in the targeting vector for selection was excised prior to germline transmission, leaving a single loxP site downstream of the GFP sequence. RT-PCR and flow cytometry indicated an absenceof endogenous protein and the presence GFP expression in homozygous mutant mice. [J:84544]

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Genotyping Protocols

Cx3cr1 tm1Litt

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, these mice are bred as homozygotes.
Diet Information LabDiet® 5K52/5K67

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View Fluorescent Protein Strains     (135 strains)

Strains carrying other alleles of GFP
006053   129-Gt(ROSA)26Sortm1Luo/J
006067   129-Gt(ROSA)26Sortm2Luo/J
006041   129-Gt(ROSA)26Sortm3Luo/J
003960   129S6-Tg(Prnp-GFP/cre)1Blw/J
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006080   B6.129-Gt(ROSA)26Sortm2Luo/J
006075   B6.129-Gt(ROSA)26Sortm3Luo/J
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008112   B6.Cg-Tg(CAG-Ub*G76V/GFP)2Dant/J
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005029   B6.Cg-Tg(Hlxb9-GFP)1Tmj/J
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003658   STOCK Tg(TIE2GFP)287Sato/J
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View Strains carrying other alleles of GFP     (78 strains)

Additional Web Information

Congenic Nomenclature
Fluorescent Proteins/lacZ Systems
Genetic Quality Control Annual Report

Animal Health Reports

Room Number           AX12

Research Applications

This mouse can be used to support research in many areas including:

Research Tools
Cell Biology Research
Fluorescent Proteins
Genetics Research (Tissue/Cell Markers: neurons)
Immunology and Inflammation Research
Neurobiology Research (cell marker)

GFP related

Research Tools
Fluorescent Proteins

References

Selected Reference(s)

Jung S; Aliberti J; Graemmel P; Sunshine MJ; Kreutzberg GW; Sher A; Littman DR. 2000. Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol 20(11):4106-14. [PubMed: 10805752]  [J:84544]

Additional References

Price and Supply Information

Strain Name: B6.129P-Cx3cr1tm1Litt/J
Stock Number: 005582

Price Details

IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.

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Supply Details

Standard SupplyRepository-Live. No age specifications accepted. Colony sized to produce minimal quantities (typically up to 6 mice) upon order receipt; one order per strain. Expected delivery: 1-3 months. Larger quantities or custom orders arranged upon request.
Supply Notes Usually shipped between four and eight weeks of age.
This strain is included in the Induced Mutant Resource Colony collection.
Genomic DNA is available for this strain from the Mouse DNA Resource.
LicensingSee General Terms and Conditions below for Licensing and Use Restrictions  
Control InformationView Control Information in Strain Details.

General Terms and Conditions

View JAX® Mice & Services Conditions of Use.

Effective September 26, 2007: License Requirements for Strains using Cre-lox Technology only apply in Canada, see Licenses for Strains using Cre-lox Technology.

For additional Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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