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Common Names: Prx1-Cre;    
This transgene expresses Cre recombinase under the control of a Prrx1 derived enhancer, and is expressed in the early limb bud mesenchyme and in a subset of craniofacial mesenchyme. This strain represents an effective tool for generating tissue specific-targeted mutants useful in studies of limb bud development and patterning.


Strain Information

Type Congenic; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemHemizygote x +/+ sibling         (Female x Male)   18-APR-08
Specieslaboratory mouse
GenerationN12+N3pN1 (17-OCT-13)
Generation Definitions
Donating Investigator Clifford J Tabin,   Harvard Medical School

Mice homozygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. These transgenic mice express Cre recombinase under the control of the paired related homeobox 1 promoter. Cre recombinase expression closely patterns endogenous gene expression and is detectable by embryonic day 9.5. Some recombination occurs in the female germline. When crossed with a strain containing a loxP site-flanked sequence of interest, Cre-mediated recombination results in deletion of the flanked sequence in early limb bud mesenchyme. This strain represents an effective tool for generating tissue specific-targeted mutants useful in studies of limb bud development and patterning.

View cre expression characterization.

A transgenic construct containing cre coding sequence under the control of the paired related homeobox 1 promoter was microinjected into B6SJLF2 donor oocytes. Founder animals were backcrossed to C57BL/6J for 12 generations.

Control Information

  Considerations for Choosing Controls

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003328   129S/Sv-Tg(Prm-cre)58Og/J
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009587   B6(129S4)-Et(icre)1402Rdav/J
009588   B6(129S4)-Et(icre)1470Rdav/J
009589   B6(129S4)-Et(icre)1555Rdav/J
009586   B6(129S4)-Et(icre)754Rdav/J
012687   B6(129S4)-Tg(SYN1-icre/mRFP1)9934Rdav/J
010774   B6(Cg)-Calb2tm1(cre)Zjh/J
017562   B6(Cg)-Cd8atm1.1(cre)Koni/J
012704   B6(Cg)-Crhtm1(cre)Zjh/J
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026801   B6(Cg)-Ins1tm1.1(cre)Thor/J
016223   B6(Cg)-Tg(Phox2b-cre)3Jke/J
016959   B6.129(Cg)-Foxp3tm4(YFP/cre)Ayr/J
023055   B6.129(Cg)-Krt12tm3(cre)Wwk/J
008320   B6.129-Leprtm2(cre)Rck/J
017526   B6.129-Nos1tm1(cre)Mgmj/J
005697   B6.129-Otx1tm4(cre)Asim/J
018938   B6.129-Tac2tm1.1(cre)Qima/J
017769   B6.129-Trpv1tm1(cre)Bbm/J
004146   B6.129-Tg(Pcp2-cre)2Mpin/J
008710   B6.129P2(129S4)-Hprttm10(Ple162-EGFP/cre)Ems/Mmjax
008877   B6.129P2(129S4)-Hprttm12(Ple177-EGFP/cre)Ems/Mmjax
009116   B6.129P2(129S4)-Hprttm16(Ple167-EGFP/cre)Ems/Mmjax
008709   B6.129P2(129S4)-Hprttm9(Ple178-EGFP/cre)Ems/Mmjax
006785   B6.129P2(C)-Cd19tm1(cre)Cgn/J
006084   B6.129P2(Cg)-Foxg1tm1(cre)Skm/J
010611   B6.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
007770   B6.129P2-Aicdatm1(cre)Mnz/J
004781   B6.129P2-Lyz2tm1(cre)Ifo/J
017320   B6.129P2-Pvalbtm1(cre)Arbr/J
017915   B6.129S(Cg)-Pgrtm1.1(cre)Shah/AndJ
013594   B6.129S-Atoh1tm5.1(Cre/PGR)Hzo/J
021794   B6.129S1(Cg)-Ascl3tm1.1(EGFP/cre)Ovi/J
024637   B6.129S1(SJL)-Nkx2-5tm2(cre)Rph/J
006600   B6.129S1-Mnx1tm4(cre)Tmj/J
005628   B6.129S2-Emx1tm1(cre)Krj/J
022510   B6.129S4-Gpr88tm1.1(cre/GFP)Rpa/J
017578   B6.129S4-Mcpt8tm1(cre)Lky/J
003755   B6.129S4-Meox2tm1(cre)Sor/J
007893   B6.129S4-Myf5tm3(cre)Sor/J
006878   B6.129S6-Taglntm2(cre)Yec/J
012839   B6.129X1(Cg)-Tnfrsf4tm2(cre)Nik/J
008712   B6.129X1-Twist2tm1.1(cre)Dor/J
006054   B6.C-Tg(CMV-cre)1Cgn/J
020811   B6.C-Tg(Pgk1-cre)1Lni/CrsJ
023530   B6.Cg-Avptm1.1(cre)Hze/J
013590   B6.Cg-Braftm1Mmcm Ptentm1Hwu Tg(Tyr-cre/ERT2)13Bos/BosJ
006230   B6.Cg-Cebpatm1Dgt Tg(Mx1-cre)1Cgn/J
012358   B6.Cg-Pvalbtm1.1(cre)Aibs/J
005622   B6.Cg-Shhtm1(EGFP/cre)Cjt/J
022762   B6.Cg-Zfp335tm1.2Caw Emx1tm1(cre)Krj/J
017346   B6.Cg-Tg(A930038C07Rik-cre)1Aibs/J
006149   B6.Cg-Tg(ACTA1-cre)79Jme/J
003574   B6.Cg-Tg(Alb-cre)21Mgn/J
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009350   B6.Cg-Tg(CDX2-cre)101Erf/J
009352   B6.Cg-Tg(CDX2-cre*)189Erf/J
027310   B6.Cg-Tg(Camk2a-cre)2Szi/J
027400   B6.Cg-Tg(Camk2a-cre)3Szi/J
005359   B6.Cg-Tg(Camk2a-cre)T29-1Stl/J
022071   B6.Cg-Tg(Cd4-cre)1Cwi/BfluJ
012237   B6.Cg-Tg(Cdh16-cre)91Igr/J
006368   B6.Cg-Tg(Cr2-cre)3Cgn/J
006663   B6.Cg-Tg(Eno2-cre)39Jme/J
005069   B6.Cg-Tg(Fabp4-cre)1Rev/J
012712   B6.Cg-Tg(Fev-cre)1Esd/J
012849   B6.Cg-Tg(GFAP-cre/ERT2)505Fmv/J
012886   B6.Cg-Tg(Gfap-cre)73.12Mvs/J
024098   B6.Cg-Tg(Gfap-cre)77.6Mvs/2J
009642   B6.Cg-Tg(Gh1-cre)1Sac/J
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008068   B6.Cg-Tg(Itgax-cre)1-1Reiz/J
008781   B6.Cg-Tg(Kap-cre)29066/2Sig/J
003802   B6.Cg-Tg(Lck-cre)548Jxm/J
006889   B6.Cg-Tg(Lck-cre)I540Jxm/J
012837   B6.Cg-Tg(Lck-icre)3779Nik/J
009643   B6.Cg-Tg(Lhb-cre)1Sac/J
008330   B6.Cg-Tg(Mc4r-cre)25Rck/J
003556   B6.Cg-Tg(Mx1-cre)1Cgn/J
007742   B6.Cg-Tg(Myh11-cre,-EGFP)2Mik/J
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006361   B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/J
003966   B6.Cg-Tg(Syn1-cre)671Jxm/J
017491   B6.Cg-Tg(Tagln-cre)1Her/J
004128   B6.Cg-Tg(Tek-cre)12Flv/J
008863   B6.Cg-Tg(Tek-cre)1Ywa/J
008601   B6.Cg-Tg(Th-cre)1Tmd/J
012328   B6.Cg-Tg(Tyr-cre/ERT2)13Bos/J
008085   B6.Cg-Tg(UBC-cre/ERT2)1Ejb/J
008610   B6.Cg-Tg(Vav1-cre)A2Kio/J
004586   B6.Cg-Tg(Vil-cre)997Gum/J
021504   B6.Cg-Tg(Vil1-cre)1000Gum/J
008735   B6.Cg-Tg(Wap-cre)11738Mam/JKnwJ
009614   B6.Cg-Tg(Wfs1-cre/ERT2)2Aibs/J
009107   B6.Cg-Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
022501   B6.Cg-Tg(Wnt1-cre)2Sor/J
006234   B6.Cg-Tg(tetO-cre)1Jaw/J
016832   B6.FVB(129)-Tg(Alb1-cre)1Dlr/J
005657   B6.FVB(129)-Tg(Myh6-cre/Esr1*)1Jmk/J
024688   B6.FVB(129S)-Tg(Pax6-GFP/cre)1Rilm/J
006475   B6.FVB(129S4)-Tg(Ckmm-cre)5Khn/J
006451   B6.FVB(129X1)-Tg(Sim1-cre)1Lowl/J
006333   B6.FVB(Cg)-Tg(Neurog3-cre)C1Able/J
014643   B6.FVB-Tg(CMA1-cre)6Thhe/J
006137   B6.FVB-Tg(Cdh5-cre)7Mlia/J
018980   B6.FVB-Tg(Ddx4-cre)1Dcas/KnwJ
003724   B6.FVB-Tg(EIIa-cre)C5379Lmgd/J
011069   B6.FVB-Tg(Gh1-cre)bKnmn/J
011038   B6.FVB-Tg(Myh6-cre)2182Mds/J
014647   B6.FVB-Tg(Pdx1-cre)6Tuv/J
010714   B6.FVB-Tg(Pomc-cre)1Lowl/J
022791   B6.FVB-Tg(Rorc-cre)1Litt/J
017535   B6.FVB-Tg(Slc32a1-cre)2.1Hzo/FrkJ
017490   B6.FVB-Tg(Stra8-icre)1Reb/LguJ
024670   B6.FVB-Tg(Ucp1-cre)1Evdr/J
003394   B6.FVB-Tg(Zp3-cre)3Mrt/J
006660   B6.SJL-Slc6a3tm1.1(cre)Bkmn/J
003552   B6129-Tg(Wap-cre)11738Mam/J
023161   B6129S-Tg(Foxp3-EGFP/cre)1aJbs/J
021025   B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-cre)Haho/J
010529   B6;129-Myf5tm1(cre)Mrc/J
010528   B6;129-Myf6tm2(cre)Mrc/J
017525   B6;129-Ntstm1(cre)Mgmj/J
005549   B6;129-Pax3tm1(cre)Joe/J
017968   B6;129-Tg(Cdh5-cre)1Spe/J
024860   B6;129-Tg(Drd1-cre)120Mxu/Mmjax
010988   B6;129P-Cyp11a1tm1(GFP/cre)Pzg/J
008529   B6;129P-Tg(Neurog1-cre/ERT2)1Good/J
012601   B6;129P2-Lyve1tm1.1(EGFP/cre)Cys/J
006668   B6;129P2-Omptm4(cre)Mom/MomJ
008069   B6;129P2-Pvalbtm1(cre)Arbr/J
012373   B6;129S-Hoxb1tm1(cre)Og/J
024234   B6;129S-Oxttm1.1(cre)Dolsn/J
023526   B6;129S-Rorbtm1.1(cre)Hze/J
023527   B6;129S-Slc17a7tm1.1(cre)Hze/J
023525   B6;129S-Snap25tm2.1(cre)Hze/J
021877   B6;129S-Tac1tm1.1(cre)Hze/J
021878   B6;129S-Tac2tm1.1(cre)Hze/J
017685   B6;129S-Wisp3tm1(cre)Mawa/J
007001   B6;129S-Tg(UBC-cre/ERT2)1Ejb/J
009388   B6;129S1-Osr2tm2(cre)Jian/J
012463   B6;129S4-Foxd1tm1(GFP/cre)Amc/J
011105   B6;129S4-Olig1tm1(cre)Rth/J
006410   B6;129S6-Chattm2(cre)Lowl/J
009616   B6;C3-Tg(A930038C07Rik-cre)4Aibs/J
012433   B6;C3-Tg(ACTA1-rtTA,tetO-cre)102Monk/J
008844   B6;C3-Tg(Ctgf-cre)2Aibs/J
008839   B6;C3-Tg(Cyp39a1-cre)1Aibs/J
009117   B6;C3-Tg(Cyp39a1-cre)7Aibs/J
008848   B6;C3-Tg(Mybpc1-cre)2Aibs/J
009111   B6;C3-Tg(Scnn1a-cre)1Aibs/J
009112   B6;C3-Tg(Scnn1a-cre)2Aibs/J
009613   B6;C3-Tg(Scnn1a-cre)3Aibs/J
009103   B6;C3-Tg(Wfs1-cre/ERT2)3Aibs/J
025806   B6;CBA-Tg(Gsx2-cre)1Kess/J
026555   B6;CBA-Tg(Lhx6-cre)1Kess/J
025807   B6;CBA-Tg(Sox10-cre)1Wdr/J
024507   B6;CBA-Tg(Tbx21-cre)1Dlc/J
017494   B6;D-Tg(Tshz3-GFP/cre)43Amc/J
024926   B6;D2-Tg(Fshr-cre)1Ldu/J
003466   B6;D2-Tg(Sycp1-cre)4Min/J
014160   B6;DBA-Tg(S100b-EGFP/cre/ERT2)22Amc/J
014159   B6;DBA-Tg(Tmem100-EGFP/cre/ERT2)30Amc/J
015855   B6;DBA-Tg(Upk3a-GFP/cre/ERT2)26Amc/J
010803   B6;FVB-Tg(Adipoq-cre)1Evdr/J
018422   B6;FVB-Tg(Aicda-cre)1Rcas/J
023748   B6;FVB-Tg(Aldh1l1-cre)JD1884Gsat/J
011087   B6;FVB-Tg(Crh-cre)1Kres/J
008533   B6;FVB-Tg(Cspg4-cre)1Akik/J
003734   B6;FVB-Tg(GZMB-cre)1Jcb/J
015850   B6;SJL-Pde6b+ Tg(Rho-icre)1Ck/Boc
004426   B6;SJL-Tg(Cga-cre)3Sac/J
003554   B6;SJL-Tg(Col2a1-cre)1Bhr/J
017738   B6;SJL-Tg(Foxl1-cre)1Khk/J
005249   B6;SJL-Tg(Krt1-15-cre/PGR)22Cot/J
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017911   B6N.129S6(Cg)-Esr1tm1.1(cre)And/J
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019021   B6N.Cg-Ccktm1.1(cre)Zjh/J
019022   B6N.Cg-Gad2tm2(cre)Zjh/J
018973   B6N.Cg-Ssttm2.1(cre)Zjh/J
018961   B6N.Cg-Tg(Alb-cre)21Mgn/J
018966   B6N.Cg-Tg(Camk2a-cre)T29-1Stl/J
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019099   B6N.FVB-Tg(ACTB-cre)2Mrt/CjDswJ
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006244   C.Cg-Tg(tetO-cre)1Jaw/J
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017557   C57BL/6-Tg(BEST1-cre)1Jdun/J
027406   C57BL/6-Tg(CD2-cre)1Lov/J
016097   C57BL/6-Tg(Car1-cre)5Flt/J
011086   C57BL/6-Tg(Cck-cre)CKres/J
008766   C57BL/6-Tg(Cd8a-cre)1Itan/J
026828   C57BL/6-Tg(Cpa3-cre)4Glli/J
006474   C57BL/6-Tg(Grik4-cre)G32-4Stl/J
008314   C57BL/6-Tg(HBB-cre)12Kpe/J
008870   C57BL/6-Tg(Hspa2-cre)1Eddy/J
016261   C57BL/6-Tg(Nes-cre/ERT2)KEisc/J
012906   C57BL/6-Tg(Nes-cre/Esr1*)1Kuan/J
027205   C57BL/6-Tg(Nms-icre)20Ywa/J
016617   C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog/J
020287   C57BL/6-Tg(Pbsn-cre/Esr1*)14Abch/J
013148   C57BL/6-Tg(Pdgfra-cre)1Clc/J
008535   C57BL/6-Tg(Pf4-cre)Q3Rsko/J
024034   C57BL/6-Tg(Pmch-cre)1Rck/J
016583   C57BL/6-Tg(Slc6a3-icre/ERT2)2Gloss/J
006888   C57BL/6-Tg(Zp3-cre)1Gwh/J
003651   C57BL/6-Tg(Zp3-cre)93Knw/J
021119   C57BL/6J-Tg(Dlx2-cre,-mCherry)4Grsr/GrsrJ
021423   C57BL/6J-Tg(Dlx2-cre,-mCherry)9Grsr/GrsrJ
007567   C57BL/6J-Tg(Itgax-cre,-EGFP)4097Ach/J
018895   C57BL/6J-Tg(Krt6,-cre,-Cerulean)1Grsr/Grsr
018896   C57BL/6J-Tg(Krt6,-cre,-Cerulean)2Grsr/Grsr
018898   C57BL/6J-Tg(Krt6,-cre,-Cerulean)4Grsr/Grsr
018899   C57BL/6J-Tg(Krt6,-cre,-Cerulean)5Grsr/Grsr
021582   C57BL/6J-Tg(Mchr1-cre)1Emf/J
008661   C57BL/6J-Tg(Nkx2-1-cre)2Sand/J
022883   C57BL/6J-Tg(Six6-cre)3Grsr/GrsrJ
022887   C57BL/6J-Tg(Six6-cre)7Grsr/GrsrJ
018754   C57BL/6J-Tg(Tbx22,-cre,-mCherry)1Grsr/GrsrJ
019363   C57BL/6J-Tg(Trp63,-cre,-Cerulean)10Grsr/Grsr
018792   C57BL/6J-Tg(Trp63,-cre,-Cerulean)4Grsr/GrsrJ
003650   C57BL/6J-Tg(Zp3-cre)82Knw/KnwJ
018151   C57BL/6N-Krt17tm1(cre,Cerulean)Murr/GrsrJ
023014   C57BL/6N-Tg(Calcrl,cre)4688Nkza/J
012686   C57BL/6N-Tg(Ppp1r2-cre)4127Nkza/J
016582   C57BL/6N-Tg(Slc32a1-icre/ERT2)3Gloss/J
026861   D2.129P2(B6)-Lyz2tm1(cre)Ifo/SjJ
026858   D2.129S4(B6)-Meox2tm1(cre)Sor/SjJ
026266   D2.B6-Tg(Zp3-cre)93Knw/SjJ
026852   D2.Cg-Tg(Gfap-cre)73.12Mvs/SjJ
024701   D2.Cg-Tg(Plp1-cre/ERT)3Pop/SjJ
026859   D2.Cg-Tg(Sox2-cre)1Amc/SjJ
026857   D2.FVB-Tg(GFAP-cre)25Mes/SjJ
026860   D2.FVB-Tg(Tek-cre)2352Rwng/SjJ
016833   FVB(Cg)-Tg(Alb1-cre)1Dlr/J
012929   FVB(Cg)-Tg(Dhh-cre)1Mejr/J
011034   FVB(Cg)-Tg(Ghrhr-cre)3242Lsk/J
006405   FVB-Tg(Ckmm-cre)5Khn/J
021024   FVB-Tg(Csf1r-icre)1Jwp/J
006954   FVB-Tg(Ddx4-cre)1Dcas/J
004600   FVB-Tg(GFAP-cre)25Mes/J
011037   FVB-Tg(Myh6-cre)2182Mds/J
006364   FVB-Tg(Nr5a1-cre)2Lowl/J
008537   FVB-Tg(Tek-cre)2352Rwng/J
019382   FVB.Cg-Myh9tm1.1Gac Tg(NPHS2-cre)295Lbh/Mmjax
014140   FVB.Cg-Myod1tm2.1(icre)Glh/J
006139   FVB.Cg-Tg(ACTA1-cre)79Jme/J
006297   FVB.Cg-Tg(Eno2-cre)39Jme/J
018394   FVB.Cg-Tg(KRT5-cre/ERT2)2Ipc/JeldJ
008244   FVB.Cg-Tg(tetO-cre)1Jaw/J
003376   FVB/N-Tg(ACTB-cre)2Mrt/J
024384   FVB/N-Tg(AMELX-cre)A1Kul/J
003314   FVB/N-Tg(EIIa-cre)C5379Lmgd/J
025062   FVB/N-Tg(Figla-EGFP,-icre)ZP3Dean/Mmjax
017928   FVB/N-Tg(Mpz-cre)26Mes/J
025066   FVB/N-Tg(Mylpf-cre)3Kraj/Mmjax
006143   FVB/N-Tg(Thy1-cre)1Vln/J
003377   FVB/N-Tg(Zp3-cre)3Mrt/J
023325   FVB;B6-Tg(Pbsn-cre)20Fwan/J
019096   NOD.129P2(B6)-Lyz2tm1(cre)Ifo/NadlJ
023806   NOD.129P2(Cg)-Cd19tm1(cre)Cgn/J
013233   NOD.B6-Tg(Itgax-cre,-EGFP)4097Ach/J
013234   NOD.Cg-Tg(Cd4-cre)1Cwi/2AchJ
023972   NOD.Cg-Tg(Ins2-cre/ERT)1Dam/SbwJ
023203   NOD.Cg-Tg(Itgax-cre)1-1Reiz/PesaJ
005732   NOD.Cg-Tg(Lck-cre)548Jxm/AchJ
023973   NOD.Cg-Tg(Neurog3-cre)1Dam/SbwJ
013251   NOD.FVB-Tg(EIIa-cre)C5379Lmgd/J
008694   NOD/ShiLt-Tg(Foxp3-EGFP/cre)1cJbs/J
004986   NOD/ShiLt-Tg(Ins2-cre)3Lt/LtJ
003855   NOD/ShiLt-Tg(Ins2-cre)5Lt/LtJ
004987   NOD/ShiLt-Tg(Ins2-cre)6Lt/LtJ
012899   STOCK Agrptm1(cre)Lowl/J
026229   STOCK Akap12tm1Ihg Rb1tm2Brn Tg(Pbsn-cre)4Prb/J
012706   STOCK Ccktm1.1(cre)Zjh/J
010910   STOCK Corttm1(cre)Zjh/J
007916   STOCK En1tm2(cre)Wrst/J
008464   STOCK Foxa2tm2.1(cre/Esr1*)Moon/J
010802   STOCK Gad2tm2(cre)Zjh/J
018903   STOCK Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
023407   STOCK HhatTg(TFAP2A-cre)1Will/J
008876   STOCK Hprttm11(Ple176-EGFP/cre)Ems/Mmjax
016879   STOCK Il17atm1.1(icre)Stck/J
024242   STOCK Isl1tm1(cre)Sev/J
018976   STOCK Kdrtm1(cre)Sato/J
017701   STOCK Kiss1tm1.1(cre/EGFP)Stei/J
007022   STOCK Mnx1tm4(cre)Tmj Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
004192   STOCK Mttptm2Sgy Ldlrtm1Her Apobtm2Sgy Tg(Mx1-cre)1Cgn/J
023342   STOCK Myf5tm1(cre/Esr1*)Trdo/J
024713   STOCK Myl1tm1(cre)Sjb/J
014180   STOCK Myocdtm1(cre)Jomm/J
006953   STOCK Notch1tm3(cre)Rko/J
006677   STOCK Olfr151tm28(cre)Mom/MomJ
011103   STOCK Olig2tm2(TVA,cre)Rth/J
010530   STOCK Pax7tm1(cre)Mrc/J
016963   STOCK Slc17a6tm2(cre)Lowl/J
016962   STOCK Slc32a1tm2(cre)Lowl/J
013044   STOCK Ssttm2.1(cre)Zjh/J
012719   STOCK Tgfb3tm1(cre)Vk/J
012620   STOCK Trp53tm1Brd Brca1tm1Aash Tg(LGB-cre)74Acl/J
010908   STOCK Viptm1(cre)Zjh/J
010911   STOCK Wt1tm1(EGFP/cre)Wtp/J
009615   STOCK Tg(Cartpt-cre)1Aibs/J
017336   STOCK Tg(Cd4-cre)1Cwi/BfluJ
005105   STOCK Tg(Chx10-EGFP/cre,-ALPP)2Clc/J
008852   STOCK Tg(En2-cre)22Alj/J
005938   STOCK Tg(Eno2-cre)39Jme/J
011062   STOCK Tg(Gdf9-cre)5092Coo/J
012841   STOCK Tg(Ggt1-cre)M3Egn/J
021207   STOCK Tg(Gnrh1-cre)1Dlc/J
017981   STOCK Tg(Hoxb6-cre)#Mku/J
004692   STOCK Tg(Hoxb7-cre)13Amc/J
014600   STOCK Tg(I12b-cre/ERT2,-ALPP)37Fsh/J
008122   STOCK Tg(Ins2-cre/ERT)1Dam/J
004782   STOCK Tg(KRT14-cre)1Amc/J
005107   STOCK Tg(KRT14-cre/ERT)20Efu/J
008582   STOCK Tg(Kcnc2-Cre)K128Stl/LetJ
023426   STOCK Tg(Kiss1-cre)J2-4Cfe/J
017836   STOCK Tg(LGB-cre)74Acl/J
003551   STOCK Tg(MMTV-cre)1Mam/J
003553   STOCK Tg(MMTV-cre)4Mam/J
002527   STOCK Tg(Mx1-cre)1Cgn/J
009074   STOCK Tg(Myh6-cre)1Jmk/J
005650   STOCK Tg(Myh6-cre/Esr1*)1Jmk/J
009102   STOCK Tg(Nefh-cre)12Kul/J
002858   STOCK Tg(Nes-cre)1Wme/J
002859   STOCK Tg(Nes-cre)2Wme/J
012859   STOCK Tg(Neurog1-cre)1Jejo/J
005667   STOCK Tg(Neurog3-cre)C1Able/J
008119   STOCK Tg(Neurog3-cre/Esr1*)1Dam/J
012462   STOCK Tg(Nr5a1-cre)7Lowl/J
014158   STOCK Tg(Pax4-cre)1Dam/J
024578   STOCK Tg(Pax6-GFP/cre)1Rilm/J
006207   STOCK Tg(Pcp2-cre)1Amc/J
014099   STOCK Tg(Pmch-cre)1Lowl/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
012452   STOCK Tg(Rr5-GFP/cre)1Sapc/J
006395   STOCK Tg(Sim1-cre)1Lowl/J
009606   STOCK Tg(Six2-EGFP/cre)1Amc/J
019755   STOCK Tg(Six3-cre)69Frty/GcoJ
018147   STOCK Tg(Slc17a8-icre)1Edw/SealJ
012586   STOCK Tg(Slc1a3-cre/ERT)1Nat/J
004783   STOCK Tg(Sox2-cre)1Amc/J
008208   STOCK Tg(Stra8-icre)1Reb/J
016236   STOCK Tg(TCF/Lef1-cre/ERT2)1Dje/J
004746   STOCK Tg(Tagln-cre)1Her/J
012708   STOCK Tg(Thy1-cre/ERT2,-EYFP)HGfng/PyngJ
024240   STOCK Tg(Tnnt2-cre)5Blh/JiaoJ
016584   STOCK Tg(Tph2-icre/ERT2)6Gloss/J
003829   STOCK Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
008851   STOCK Tg(Wnt1-cre/ERT)1Alj/J
018281   STOCK Tg(Wnt7a-EGFP/cre)#Bhr/Mmjax
008199   STOCK Tg(dlx6a-cre)1Mekk/J
002471   STOCK Tg(hCMV-cre)140Sau/J
023724   STOCK Tg(mI56i-cre,EGFP)1Kc/J
006224   STOCK Tg(tetO-cre)1Jaw/J
View Strains carrying other alleles of cre     (402 strains)

Additional Web Information

Introduction to Cre-lox technology


Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Developmental Biology Research
Craniofacial and Palate Defects
      Orofacial clefting-specific cre expression

Research Tools
Cre-lox System
      Cre Recombinase Expression

cre related

Research Tools
Cre-lox System
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Cre-lox System

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Tg(Prrx1-cre)1Cjt
Allele Name transgene insertion 1, Clifford J Tabin
Allele Type Transgenic (cre- or Flp-expressing)
Common Name(s) Prx-1 Cre; Prx-cre; Prx1-cre; Prx1cre; Prx1Cre; Tg[Prx1-cre]1Cjt;
Mutation Made By Malcolm Logan,   National Institute for Medical Research
Strain of Origin(C57BL/6J x SJL/J)F2
Site of Expressionearly limb bud mesenchyme and in a subset of craniofacial mesenchyme, some female germline expression
Expressed Gene cre, cre recombinase, bacteriophage P1
Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence.
Promoter Prrx1, paired related homeobox 1, rat
Driver Note Prrx1
Molecular Note This transgene expresses Cre recombinase under the control of a Prrx1 derived enhancer. This transgene is expressed in the early limb bud mesenchyme and in a subset of craniofacial mesenchyme. A germline Cre recombinase activity was observed in female, but not in male, as partially penetrant trait depending on the particular gene flanked by loxP sites. [MGI Ref ID J:77872]


Genotyping Information

Genotyping Protocols

Generic Cre Melt Curve Analysis, MELT
Generic Cre Melt Curve Analysis, Probe
Generic Cre, Standard PCR

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Logan M; Martin JF; Nagy A; Lobe C; Olson EN; Tabin CJ. 2002. Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer. Genesis 33(2):77-80. [PubMed: 12112875]  [MGI Ref ID J:77872]

Additional References

Tg(Prrx1-cre)1Cjt related

Abula K; Muneta T; Miyatake K; Yamada J; Matsukura Y; Inoue M; Sekiya I; Graf D; Economides AN; Rosen V; Tsuji K. 2015. Elimination of BMP7 from the developing limb mesenchyme leads to articular cartilage degeneration and synovial inflammation with increased age. FEBS Lett 589(11):1240-8. [PubMed: 25889639]  [MGI Ref ID J:221175]

Ahrens MJ; Li Y; Jiang H; Dudley AT. 2009. Convergent extension movements in growth plate chondrocytes require gpi-anchored cell surface proteins. Development 136(20):3463-74. [PubMed: 19762422]  [MGI Ref ID J:153618]

Aizawa R; Yamada A; Suzuki D; Iimura T; Kassai H; Harada T; Tsukasaki M; Yamamoto G; Tachikawa T; Nakao K; Yamamoto M; Yamaguchi A; Aiba A; Kamijo R. 2012. Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development. Mech Dev 129(1-4):38-50. [PubMed: 22387309]  [MGI Ref ID J:184022]

Akiyama H; Chaboissier MC; Martin JF; Schedl A; De Crombrugghe B. 2002. The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev 16(21):2813-28. [PubMed: 12414734]  [MGI Ref ID J:79879]

Akiyama R; Kawakami H; Wong J; Oishi I; Nishinakamura R; Kawakami Y. 2015. Sall4-Gli3 system in early limb progenitors is essential for the development of limb skeletal elements. Proc Natl Acad Sci U S A 112(16):5075-80. [PubMed: 25848055]  [MGI Ref ID J:220960]

Almeida M; Iyer S; Martin-Millan M; Bartell SM; Han L; Ambrogini E; Onal M; Xiong J; Weinstein RS; Jilka RL; O'Brien CA; Manolagas SC. 2013. Estrogen receptor-alpha signaling in osteoblast progenitors stimulates cortical bone accrual. J Clin Invest 123(1):394-404. [PubMed: 23221342]  [MGI Ref ID J:194156]

Amarilio R; Viukov SV; Sharir A; Eshkar-Oren I; Johnson RS; Zelzer E. 2007. HIF1{alpha} regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis. Development 134(21):3917-28. [PubMed: 17913788]  [MGI Ref ID J:126336]

Araldi E; Khatri R; Giaccia AJ; Simon MC; Schipani E. 2011. Lack of HIF-2alpha in limb bud mesenchyme causes a modest and transient delay of endochondral bone development. Nat Med 17(1):25-6; author reply 27-9. [PubMed: 21217667]  [MGI Ref ID J:168583]

Bandyopadhyay A; Tsuji K; Cox K; Harfe BD; Rosen V; Tabin CJ. 2006. Genetic Analysis of the Roles of BMP2, BMP4, and BMP7 in Limb Patterning and Skeletogenesis. PLoS Genet 2(12):e216. [PubMed: 17194222]  [MGI Ref ID J:118257]

Bangs F; Antonio N; Thongnuek P; Welten M; Davey MG; Briscoe J; Tickle C. 2011. Generation of mice with functional inactivation of talpid3, a gene first identified in chicken. Development 138(15):3261-72. [PubMed: 21750036]  [MGI Ref ID J:175541]

Barrott JJ; Cash GM; Smith AP; Barrow JR; Murtaugh LC. 2011. Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome. Proc Natl Acad Sci U S A :. [PubMed: 21768372]  [MGI Ref ID J:173672]

Benazet JD; Pignatti E; Nugent A; Unal E; Laurent F; Zeller R. 2012. Smad4 is required to induce digit ray primordia and to initiate the aggregation and differentiation of chondrogenic progenitors in mouse limb buds. Development 139(22):4250-60. [PubMed: 23034633]  [MGI Ref ID J:189073]

Bensoussan-Trigano V; Lallemand Y; Saint Cloment C; Robert B. 2011. Msx1 and Msx2 in limb mesenchyme modulate digit number and identity. Dev Dyn 240(5):1190-202. [PubMed: 21465616]  [MGI Ref ID J:171190]

Bhattaram P; Penzo-Mendez A; Sock E; Colmenares C; Kaneko KJ; Vassilev A; Depamphilis ML; Wegner M; Lefebvre V. 2010. Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors. Nat Commun 1:9. [PubMed: 20596238]  [MGI Ref ID J:175338]

Bickley SR; Logan MP. 2014. Regulatory modulation of the T-box gene Tbx5 links development, evolution, and adaptation of the sternum. Proc Natl Acad Sci U S A 111(50):17917-22. [PubMed: 25468972]  [MGI Ref ID J:217810]

Bimonte S; De Angelis A; Quagliata L; Giusti F; Tammaro R; Dallai R; Ascenzi MG; Diez-Roux G; Franco B. 2011. Ofd1 is required in limb bud patterning and endochondral bone development. Dev Biol 349(2):179-91. [PubMed: 20920500]  [MGI Ref ID J:168038]

Blitz E; Sharir A; Akiyama H; Zelzer E. 2013. Tendon-bone attachment unit is formed modularly by a distinct pool of Scx- and Sox9-positive progenitors. Development 140(13):2680-90. [PubMed: 23720048]  [MGI Ref ID J:198653]

Blitz E; Viukov S; Sharir A; Shwartz Y; Galloway JL; Pryce BA; Johnson RL; Tabin CJ; Schweitzer R; Zelzer E. 2009. Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction. Dev Cell 17(6):861-73. [PubMed: 20059955]  [MGI Ref ID J:156015]

Bobick BE; Cobb J. 2012. Shox2 regulates progression through chondrogenesis in the mouse proximal limb. J Cell Sci 125(Pt 24):6071-83. [PubMed: 23038774]  [MGI Ref ID J:200262]

Bruce SJ; Butterfield NC; Metzis V; Town L; McGlinn E; Wicking C. 2010. Inactivation of Patched1 in the mouse limb has novel inhibitory effects on the chondrogenic program. J Biol Chem 285(36):27967-81. [PubMed: 20576618]  [MGI Ref ID J:166182]

Butterfield NC; Metzis V; McGlinn E; Bruce SJ; Wainwright BJ; Wicking C. 2009. Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limb. Development 136(20):3515-24. [PubMed: 19783740]  [MGI Ref ID J:153595]

Calo E; Quintero-Estades JA; Danielian PS; Nedelcu S; Berman SD; Lees JA. 2010. Rb regulates fate choice and lineage commitment in vivo. Nature 466(7310):1110-4. [PubMed: 20686481]  [MGI Ref ID J:163313]

Canalis E; Zanotti S; Beamer WG; Economides AN; Smerdel-Ramoya A. 2010. Connective tissue growth factor is required for skeletal development and postnatal skeletal homeostasis in male mice. Endocrinology 151(8):3490-501. [PubMed: 20534727]  [MGI Ref ID J:163027]

Chappuis V; Gamer L; Cox K; Lowery JW; Bosshardt DD; Rosen V. 2012. Periosteal BMP2 activity drives bone graft healing. Bone 51(4):800-9. [PubMed: 22846673]  [MGI Ref ID J:193357]

Chen J; Holguin N; Shi Y; Silva MJ; Long F. 2015. mTORC2 Signaling Promotes Skeletal Growth and Bone Formation in Mice. J Bone Miner Res 30(2):369-78. [PubMed: 25196701]  [MGI Ref ID J:218063]

Chen J; Long F. 2014. mTORC1 signaling controls mammalian skeletal growth through stimulation of protein synthesis. Development 141(14):2848-54. [PubMed: 24948603]  [MGI Ref ID J:213870]

Chen Y; Gridley T. 2013. Compensatory regulation of the Snai1 and Snai2 genes during chondrogenesis. J Bone Miner Res 28(6):1412-21. [PubMed: 23322385]  [MGI Ref ID J:211539]

Choocheep K; Hatano S; Takagi H; Watanabe H; Kimata K; Kongtawelert P; Watanabe H. 2010. Versican facilitates chondrocyte differentiation and regulates joint morphogenesis. J Biol Chem 285(27):21114-25. [PubMed: 20404343]  [MGI Ref ID J:165936]

Cobb J; Dierich A; Huss-Garcia Y; Duboule D. 2006. A mouse model for human short-stature syndromes identifies Shox2 as an upstream regulator of Runx2 during long-bone development. Proc Natl Acad Sci U S A 103(12):4511-5. [PubMed: 16537395]  [MGI Ref ID J:107668]

Compagni A; Logan M; Klein R; Adams RH. 2003. Control of skeletal patterning by ephrinB1-EphB interactions. Dev Cell 5(2):217-30. [PubMed: 12919674]  [MGI Ref ID J:110732]

Cook JR; Smaldone S; Cozzolino C; Del Solar M; Lee-Arteaga S; Nistala H; Ramirez F. 2012. Generation of Fbn1 conditional null mice implicates the extracellular microfibrils in osteoprogenitor recruitment. Genesis 50(8):635-41. [PubMed: 22374917]  [MGI Ref ID J:187484]

Cui Y; Niziolek PJ; Macdonald BT; Zylstra CR; Alenina N; Robinson DR; Zhong Z; Matthes S; Jacobsen CM; Conlon RA; Brommage R; Liu Q; Mseeh F; Powell DR; Yang QM; Zambrowicz B; Gerrits H; Gossen JA; He X; Bader M; Williams BO; Warman ML; Robling AG. 2011. Lrp5 functions in bone to regulate bone mass. Nat Med 17(6):684-91. [PubMed: 21602802]  [MGI Ref ID J:172746]

DeRouen MC; Zhen H; Tan SH; Williams S; Marinkovich MP; Oro AE. 2010. Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation. BMC Dev Biol 10:112. [PubMed: 21067603]  [MGI Ref ID J:166772]

Demehri S; Liu Z; Lee J; Lin MH; Crosby SD; Roberts CJ; Grigsby PW; Miner JH; Farr AG; Kopan R. 2008. Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity. PLoS Biol 6(5):e123. [PubMed: 18507503]  [MGI Ref ID J:139386]

Dicke N; Pielensticker N; Degen J; Hecker J; Tress O; Bald T; Gellhaus A; Winterhager E; Willecke K. 2011. Peripheral lymphangiogenesis in mice depends on ectodermal connexin-26 (Gjb2). J Cell Sci 124(Pt 16):2806-15. [PubMed: 21807945]  [MGI Ref ID J:188626]

Ding L; Morrison SJ. 2013. Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature 495(7440):231-5. [PubMed: 23434755]  [MGI Ref ID J:194748]

Dobrowolski R; Hertig G; Lechner H; Worsdorfer P; Wulf V; Dicke N; Eckert D; Bauer R; Schorle H; Willecke K. 2009. Loss of connexin43-mediated gap junctional coupling in the mesenchyme of limb buds leads to altered expression of morphogens in mice. Hum Mol Genet 18(15):2899-911. [PubMed: 19439426]  [MGI Ref ID J:150209]

Dong Y; Jesse AM; Kohn A; Gunnell LM; Honjo T; Zuscik MJ; O'Keefe RJ; Hilton MJ. 2010. RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development. Development 137(9):1461-71. [PubMed: 20335360]  [MGI Ref ID J:159860]

Dubail J; Aramaki-Hattori N; Bader HL; Nelson CM; Katebi N; Matuska B; Olsen BR; Apte SS. 2014. A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web regression. Genesis 52(7):702-12. [PubMed: 24753090]  [MGI Ref ID J:213412]

Dudanova I; Kao TJ; Herrmann JE; Zheng B; Kania A; Klein R. 2012. Genetic evidence for a contribution of EphA:ephrinA reverse signaling to motor axon guidance. J Neurosci 32(15):5209-15. [PubMed: 22496566]  [MGI Ref ID J:184451]

Durland JL; Sferlazzo M; Logan M; Burke AC. 2008. Visualizing the lateral somitic frontier in the Prx1Cre transgenic mouse. J Anat 212(5):590-602. [PubMed: 18430087]  [MGI Ref ID J:209265]

Dy P; Han Y; Lefebvre V. 2008. Generation of mice harboring a Sox5 conditional null allele. Genesis 46(6):294-9. [PubMed: 18543318]  [MGI Ref ID J:137217]

Dy P; Smits P; Silvester A; Penzo-Mendez A; Dumitriu B; Han Y; de la Motte CA; Kingsley DM; Lefebvre V. 2010. Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage. Dev Biol 341(2):346-59. [PubMed: 20206616]  [MGI Ref ID J:160493]

Dy P; Wang W; Bhattaram P; Wang Q; Wang L; Ballock RT; Lefebvre V. 2012. Sox9 directs hypertrophic maturation and blocks osteoblast differentiation of growth plate chondrocytes. Dev Cell 22(3):597-609. [PubMed: 22421045]  [MGI Ref ID J:183084]

El Khassawna T; Toben D; Kolanczyk M; Schmidt-Bleek K; Koennecke I; Schell H; Mundlos S; Duda GN. 2012. Deterioration of fracture healing in the mouse model of NF1 long bone dysplasia. Bone 51(4):651-60. [PubMed: 22868293]  [MGI Ref ID J:193350]

Eshkar-Oren I; Krief S; Ferrara N; Elliott AM; Zelzer E. 2015. Vascular patterning regulates interdigital cell death by a ROS-mediated mechanism. Development 142(4):672-80. [PubMed: 25617432]  [MGI Ref ID J:218159]

Eshkar-Oren I; Viukov SV; Salameh S; Krief S; Oh CD; Akiyama H; Gerber HP; Ferrara N; Zelzer E. 2009. The forming limb skeleton serves as a signaling center for limb vasculature patterning via regulation of Vegf. Development 136(8):1263-72. [PubMed: 19261698]  [MGI Ref ID J:147285]

Eyal S; Blitz E; Shwartz Y; Akiyama H; Schweitzer R; Zelzer E. 2015. On the development of the patella. Development 142(10):1831-9. [PubMed: 25926361]  [MGI Ref ID J:221660]

Farin HF; Ludtke TH; Schmidt MK; Placzko S; Schuster-Gossler K; Petry M; Christoffels VM; Kispert A. 2013. Tbx2 terminates shh/fgf signaling in the developing mouse limb bud by direct repression of gremlin1. PLoS Genet 9(4):e1003467. [PubMed: 23633963]  [MGI Ref ID J:200023]

Francis JC; Radtke F; Logan MP. 2005. Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud. Dev Dyn 234(4):1006-15. [PubMed: 16245338]  [MGI Ref ID J:102852]

Frank DU; Emechebe U; Thomas KR; Moon AM. 2013. Mouse TBX3 mutants suggest novel molecular mechanisms for Ulnar-mammary syndrome. PLoS One 8(7):e67841. [PubMed: 23844108]  [MGI Ref ID J:204305]

Fujimori S; Novak H; Weissenbock M; Jussila M; Goncalves A; Zeller R; Galloway J; Thesleff I; Hartmann C. 2010. Wnt/beta-catenin signaling in the dental mesenchyme regulates incisor development by regulating Bmp4. Dev Biol 348(1):97-106. [PubMed: 20883686]  [MGI Ref ID J:166947]

Galli A; Robay D; Osterwalder M; Bao X; Benazet JD; Tariq M; Paro R; Mackem S; Zeller R. 2010. Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development. PLoS Genet 6(4):e1000901. [PubMed: 20386744]  [MGI Ref ID J:159210]

Gamer LW; Tsuji K; Cox K; Capelo LP; Lowery J; Beppu H; Rosen V. 2011. BMPR-II is dispensable for formation of the limb skeleton. Genesis 49(9):719-24. [PubMed: 21538804]  [MGI Ref ID J:175737]

Gao Y; Lan Y; Liu H; Jiang R. 2011. The zinc finger transcription factors Osr1 and Osr2 control synovial joint formation. Dev Biol 352(1):83-91. [PubMed: 21262216]  [MGI Ref ID J:171478]

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Sheth R; Gregoire D; Dumouchel A; Scotti M; Pham JM; Nemec S; Bastida MF; Ros MA; Kmita M. 2013. Decoupling the function of Hox and Shh in developing limb reveals multiple inputs of Hox genes on limb growth. Development 140(10):2130-8. [PubMed: 23633510]  [MGI Ref ID J:197026]

Shim JH; Greenblatt MB; Zou W; Huang Z; Wein MN; Brady N; Hu D; Charron J; Brodkin HR; Petsko GA; Zaller D; Zhai B; Gygi S; Glimcher LH; Jones DC. 2013. Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts. J Clin Invest 123(9):4010-22. [PubMed: 23945236]  [MGI Ref ID J:201597]

Shoham AB; Malkinson G; Krief S; Shwartz Y; Ely Y; Ferrara N; Yaniv K; Zelzer E. 2012. S1P1 inhibits sprouting angiogenesis during vascular development. Development 139(20):3859-69. [PubMed: 22951644]  [MGI Ref ID J:187683]

Shung CY; Ota S; Zhou ZQ; Keene DR; Hurlin PJ. 2012. Disruption of a Sox9-beta-catenin circuit by mutant Fgfr3 in thanatophoric dysplasia type II. Hum Mol Genet 21(21):4628-44. [PubMed: 22843502]  [MGI Ref ID J:187998]

Solomon LA; Russell BA; Watson LA; Beier F; Berube NG. 2013. Targeted loss of the ATR-X syndrome protein in the limb mesenchyme of mice causes brachydactyly. Hum Mol Genet 22(24):5015-25. [PubMed: 23892236]  [MGI Ref ID J:203136]

Song H; Mak KK; Topol L; Yun K; Hu J; Garrett L; Chen Y; Park O; Chang J; Simpson RM; Wang CY; Gao B; Jiang J; Yang Y. 2010. Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A :. [PubMed: 20080598]  [MGI Ref ID J:156541]

Soshnikova N; Montavon T; Leleu M; Galjart N; Duboule D. 2010. Functional analysis of CTCF during mammalian limb development. Dev Cell 19(6):819-30. [PubMed: 21145498]  [MGI Ref ID J:169050]

Spagnoli A; O'Rear L; Chandler RL; Granero-Molto F; Mortlock DP; Gorska AE; Weis JA; Longobardi L; Chytil A; Shimer K; Moses HL. 2007. TGF-beta signaling is essential for joint morphogenesis. J Cell Biol 177(6):1105-17. [PubMed: 17576802]  [MGI Ref ID J:134924]

Spater D; Hill TP; O'sullivan RJ; Gruber M; Conner DA; Hartmann C. 2006. Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis. Development 133(15):3039-49. [PubMed: 16818445]  [MGI Ref ID J:119030]

Straessler KM; Jones KB; Hu H; Jin H; van de Rijn M; Capecchi MR. 2013. Modeling clear cell sarcomagenesis in the mouse: cell of origin differentiation state impacts tumor characteristics. Cancer Cell 23(2):215-27. [PubMed: 23410975]  [MGI Ref ID J:194308]

Sullivan K; El-Hoss J; Quinlan KG; Deo N; Garton F; Seto JT; Gdalevitch M; Turner N; Cooney GJ; Kolanczyk M; North KN; Little DG; Schindeler A. 2014. NF1 is a critical regulator of muscle development and metabolism. Hum Mol Genet 23(5):1250-9. [PubMed: 24163128]  [MGI Ref ID J:206219]

Suzuki D; Yamada A; Amano T; Yasuhara R; Kimura A; Sakahara M; Tsumaki N; Takeda S; Tamura M; Nakamura M; Wada N; Nohno T; Shiroishi T; Aiba A; Kamijo R. 2009. Essential mesenchymal role of small GTPase Rac1 in interdigital programmed cell death during limb development. Dev Biol 335(2):396-406. [PubMed: 19766620]  [MGI Ref ID J:154460]

Tarchini B; Duboule D; Kmita M. 2006. Regulatory constraints in the evolution of the tetrapod limb anterior-posterior polarity. Nature 443(7114):985-8. [PubMed: 17066034]  [MGI Ref ID J:114566]

Tsuji K; Bandyopadhyay A; Harfe BD; Cox K; Kakar S; Gerstenfeld L; Einhorn T; Tabin CJ; Rosen V. 2006. BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Nat Genet 38(12):1424-9. [PubMed: 17099713]  [MGI Ref ID J:116480]

Tsuji K; Cox K; Gamer L; Graf D; Economides A; Rosen V. 2010. Conditional deletion of BMP7 from the limb skeleton does not affect bone formation or fracture repair. J Orthop Res 28(3):384-9. [PubMed: 19780203]  [MGI Ref ID J:221705]

Tu X; Chen J; Lim J; Karner CM; Lee SY; Heisig J; Wiese C; Surendran K; Kopan R; Gessler M; Long F. 2012. Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1. PLoS Genet 8(3):e1002577. [PubMed: 22457635]  [MGI Ref ID J:183534]

Valasek P; Theis S; Delaurier A; Hinits Y; Luke GN; Otto AM; Minchin J; He L; Christ B; Brooks G; Sang H; Evans DJ; Logan M; Huang R; Patel K. 2011. Cellular and molecular investigations into the development of the pectoral girdle. Dev Biol 357(1):108-16. [PubMed: 21741963]  [MGI Ref ID J:175550]

Vickerman L; Neufeld S; Cobb J. 2011. Shox2 function couples neural, muscular and skeletal development in the proximal forelimb. Dev Biol 350(2):323-36. [PubMed: 21156168]  [MGI Ref ID J:170400]

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Wein MN; Jones DC; Shim JH; Aliprantis AO; Sulyanto R; Lazarevic V; Poliachik SL; Gross TS; Glimcher LH. 2012. Control of bone resorption in mice by Schnurri-3. Proc Natl Acad Sci U S A 109(21):8173-8. [PubMed: 22573816]  [MGI Ref ID J:184764]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX18

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, hemizygous transgenic mice are bred to wildtype siblings. Homozygous mice, reportedly, are viable and fertile.
Mating SystemHemizygote x +/+ sibling         (Female x Male)   18-APR-08

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $239.00Female or MaleHemizygous for Tg(Prrx1-cre)1Cjt  
Price per Pair (US dollars $)Pair Genotype
$313.00Hemizygous for Tg(Prrx1-cre)1Cjt x Noncarrier  
$313.00Noncarrier x Hemizygous for Tg(Prrx1-cre)1Cjt  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $310.70Female or MaleHemizygous for Tg(Prrx1-cre)1Cjt  
Price per Pair (US dollars $)Pair Genotype
$406.90Hemizygous for Tg(Prrx1-cre)1Cjt x Noncarrier  
$406.90Noncarrier x Hemizygous for Tg(Prrx1-cre)1Cjt  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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- Use of MICE by companies or for-profit entities requires a license prior to shipping.

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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.