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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Hemizygote x +/+ sibling (Female x Male) 18-APR-08 Species laboratory mouse Generation N12+2F6 (05-MAY-09) Donating Investigator Clifford Tabin, Harvard Medical School Description
Mice homozygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. These transgenic mice express Cre recombinase under the control of the paired related homeobox 1 promoter. Cre recombinase expression closely patterns endogenous gene expression and is detectable by embryonic day 9.5. Some recombination occurs in the female germline. When crossed with a strain containing a loxP site-flanked sequence of interest, Cre-mediated recombination results in deletion of the flanked sequence in early limb bud mesenchyme. This strain represents an effective tool for generating tissue specific-targeted mutants useful in studies of limb bud development and patterning.Development
A transgenic construct containing cre coding sequence under the control of the paired related homeobox 1 promoter was microinjected into B6SJLF2 donor oocytes. Founder animals were backcrossed to C57BL/6J for 12 generations.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of cre
View Strains carrying other alleles of cre (162 strains)
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System
Cre Recombinase Expression
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tg(Prrx1-cre)1Cjt | ||
|---|---|---|---|
| Allele Name | transgene insertion 1, Clifford J Tabin | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | Prx-1 Cre; Prx-cre; Prx1-cre; Prx1cre; Prx1Cre; | ||
| Mutation Made By | Malcolm Logan, National Institute for Medical Research | ||
| Strain of Origin | (C57BL/6J x SJL/J)F2 | ||
| Site of Expression | early limb bud mesenchyme and in a subset of craniofacial mesenchyme, some female germline expression | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Prrx1, paired related homeobox 1, rat | ||
| Driver Note | Prrx1 | ||
| Molecular Note | This transgene expresses Cre recombinase under the control of a Prrx1 derived enhancer. This transgene is expressed in the early limb bud mesenchyme and in a subset of craniofacial mesenchyme. A germline Cre recombinase activity was observed in female, but not in male, as partially penetrant trait depending on the particular gene flanked by loxP sites. [MGI Ref ID J:77872] | ||
| Gene Symbol and Name | Tg(Prrx1-cre)1Cjt, transgene insertion 1, Clifford J Tabin | ||
| Chromosome | UN | ||
| Gene Common Name(s) | Prx-1 Cre; Prx-cre; Prx1-cre; Prx1cre; Prx1Cre; | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre Melt Curve Analysis, Melt Curve Analysis
Generic Cre, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Logan M; Martin JF; Nagy A; Lobe C; Olson EN; Tabin CJ. 2002. Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer. Genesis 33(2):77-80. [PubMed: 12112875] [MGI Ref ID J:77872]
Additional References
Tg(Prrx1-cre)1Cjt relatedAhrens MJ; Li Y; Jiang H; Dudley AT. 2009. Convergent extension movements in growth plate chondrocytes require gpi-anchored cell surface proteins. Development 136(20):3463-74. [PubMed: 19762422] [MGI Ref ID J:153618]
Akiyama H; Chaboissier MC; Martin JF; Schedl A; De Crombrugghe B. 2002. The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev 16(21):2813-28. [PubMed: 12414734] [MGI Ref ID J:79879]
Amarilio R; Viukov SV; Sharir A; Eshkar-Oren I; Johnson RS; Zelzer E. 2007. HIF1{alpha} regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis. Development 134(21):3917-28. [PubMed: 17913788] [MGI Ref ID J:126336]
Bandyopadhyay A; Tsuji K; Cox K; Harfe BD; Rosen V; Tabin CJ. 2006. Genetic Analysis of the Roles of BMP2, BMP4, and BMP7 in Limb Patterning and Skeletogenesis. PLoS Genet 2(12):e216. [PubMed: 17194222] [MGI Ref ID J:118257]
Butterfield NC; Metzis V; McGlinn E; Bruce SJ; Wainwright BJ; Wicking C. 2009. Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limb. Development 136(20):3515-24. [PubMed: 19783740] [MGI Ref ID J:153595]
Cobb J; Dierich A; Huss-Garcia Y; Duboule D. 2006. A mouse model for human short-stature syndromes identifies Shox2 as an upstream regulator of Runx2 during long-bone development. Proc Natl Acad Sci U S A 103(12):4511-5. [PubMed: 16537395] [MGI Ref ID J:107668]
Compagni A; Logan M; Klein R; Adams RH. 2003. Control of skeletal patterning by ephrinB1-EphB interactions. Dev Cell 5(2):217-30. [PubMed: 12919674] [MGI Ref ID J:110732]
Demehri S; Liu Z; Lee J; Lin MH; Crosby SD; Roberts CJ; Grigsby PW; Miner JH; Farr AG; Kopan R. 2008. Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity. PLoS Biol 6(5):e123. [PubMed: 18507503] [MGI Ref ID J:139386]
Dobrowolski R; Hertig G; Lechner H; Worsdorfer P; Wulf V; Dicke N; Eckert D; Bauer R; Schorle H; Willecke K. 2009. Loss of connexin43-mediated gap junctional coupling in the mesenchyme of limb buds leads to altered expression of morphogens in mice. Hum Mol Genet 18(15):2899-911. [PubMed: 19439426] [MGI Ref ID J:150209]
Dy P; Han Y; Lefebvre V. 2008. Generation of mice harboring a Sox5 conditional null allele. Genesis 46(6):294-9. [PubMed: 18543318] [MGI Ref ID J:137217]
Eshkar-Oren I; Viukov SV; Salameh S; Krief S; Oh CD; Akiyama H; Gerber HP; Ferrara N; Zelzer E. 2009. The forming limb skeleton serves as a signaling center for limb vasculature patterning via regulation of Vegf. Development 136(8):1263-72. [PubMed: 19261698] [MGI Ref ID J:147285]
Francis JC; Radtke F; Logan MP. 2005. Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud. Dev Dyn 234(4):1006-15. [PubMed: 16245338] [MGI Ref ID J:102852]
Harfe BD; McManus MT; Mansfield JH; Hornstein E; Tabin CJ. 2005. The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci U S A 102(31):10898-903. [PubMed: 16040801] [MGI Ref ID J:100475]
Hasson P; Del Buono J; Logan MP. 2007. Tbx5 is dispensable for forelimb outgrowth. Development 134(1):85-92. [PubMed: 17138667] [MGI Ref ID J:117064]
Haycraft CJ; Zhang Q; Song B; Jackson WS; Detloff PJ; Serra R; Yoder BK. 2007. Intraflagellar transport is essential for endochondral bone formation. Development 134(2):307-16. [PubMed: 17166921] [MGI Ref ID J:117033]
Hill TP; Spater D; Taketo MM; Birchmeier W; Hartmann C. 2005. Canonical Wnt/beta-Catenin Signaling Prevents Osteoblasts from Differentiating into Chondrocytes. Dev Cell 8(5):727-38. [PubMed: 15866163] [MGI Ref ID J:98426]
Hill TP; Taketo MM; Birchmeier W; Hartmann C. 2006. Multiple roles of mesenchymal beta-catenin during murine limb patterning. Development 133(7):1219-29. [PubMed: 16495310] [MGI Ref ID J:144140]
Johnson ET; Nicola T; Roarty K; Yoder BK; Haycraft CJ; Serra R. 2008. Role for primary cilia in the regulation of mouse ovarian function. Dev Dyn 237(8):2053-60. [PubMed: 18629867] [MGI Ref ID J:138332]
Kmita M; Tarchini B; Zakany J; Logan M; Tabin CJ; Duboule D. 2005. Early developmental arrest of mammalian limbs lacking HoxA/HoxD gene function. Nature 435(7045):1113-6. [PubMed: 15973411] [MGI Ref ID J:99350]
Kolanczyk M; Kossler N; Kuhnisch J; Lavitas L; Stricker S; Wilkening U; Manjubala I; Fratzl P; Sporle R; Herrmann BG; Parada LF; Kornak U; Mundlos S. 2007. Multiple roles for neurofibromin in skeletal development and growth. Hum Mol Genet 16(8):874-86. [PubMed: 17317783] [MGI Ref ID J:121700]
Kolpakova-Hart E; Jinnin M; Hou B; Fukai N; Olsen BR. 2007. Kinesin-2 controls development and patterning of the vertebrate skeleton by Hedgehog- and Gli3-dependent mechanisms. Dev Biol 309(2):273-84. [PubMed: 17698054] [MGI Ref ID J:124871]
Lehman JM; Laag E; Michaud EJ; Yoder BK. 2009. An essential role for dermal primary cilia in hair follicle morphogenesis. J Invest Dermatol 129(2):438-48. [PubMed: 18987668] [MGI Ref ID J:150229]
Lin PP; Pandey MK; Jin F; Raymond AK; Akiyama H; Lozano G. 2009. Targeted mutation of p53 and Rb in mesenchymal cells of the limb bud produces sarcomas in mice. Carcinogenesis 30(10):1789-95. [PubMed: 19635748] [MGI Ref ID J:153430]
Lin PP; Pandey MK; Jin F; Xiong S; Deavers M; Parant JM; Lozano G. 2008. EWS-FLI1 induces developmental abnormalities and accelerates sarcoma formation in a transgenic mouse model. Cancer Res 68(21):8968-75. [PubMed: 18974141] [MGI Ref ID J:140636]
Liu W; Selever J; Wang D; Lu MF; Moses KA; Schwartz RJ; Martin JF. 2004. Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling. Proc Natl Acad Sci U S A 101(13):4489-94. [PubMed: 15070745] [MGI Ref ID J:89237]
Mao J; McGlinn E; Huang P; Tabin CJ; McMahon AP. 2009. Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb. Dev Cell 16(4):600-6. [PubMed: 19386268] [MGI Ref ID J:149478]
Matsumoto K; Li Y; Jakuba C; Sugiyama Y; Sayo T; Okuno M; Dealy CN; Toole BP; Takeda J; Yamaguchi Y; Kosher RA. 2009. Conditional inactivation of Has2 reveals a crucial role for hyaluronan in skeletal growth, patterning, chondrocyte maturation and joint formation in the developing limb. Development 136(16):2825-35. [PubMed: 19633173] [MGI Ref ID J:152912]
Matsushita T; Chan YY; Kawanami A; Balmes G; Landreth GE; Murakami S. 2009. Extracellular signal-regulated kinase 1 (ERK1) and ERK2 play essential roles in osteoblast differentiation and in supporting osteoclastogenesis. Mol Cell Biol 29(21):5843-57. [PubMed: 19737917] [MGI Ref ID J:153980]
Matsushita T; Wilcox WR; Chan YY; Kawanami A; Bukulmez H; Balmes G; Krejci P; Mekikian PB; Otani K; Yamaura I; Warman ML; Givol D; Murakami S. 2009. FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway. Hum Mol Genet 18(2):227-40. [PubMed: 18923003] [MGI Ref ID J:143273]
McGlinn E; Richman JM; Metzis V; Town L; Butterfield NC; Wainwright BJ; Wicking C. 2008. Expression of the NET family member Zfp503 is regulated by hedgehog and BMP signaling in the limb. Dev Dyn 237(4):1172-82. [PubMed: 18351672] [MGI Ref ID J:132977]
Minguillon C; Del Buono J; Logan MP. 2005. Tbx5 and Tbx4 are not sufficient to determine limb-specific morphologies but have common roles in initiating limb outgrowth. Dev Cell 8(1):75-84. [PubMed: 15621531] [MGI Ref ID J:95804]
Murakami S; Balmes G; McKinney S; Zhang Z; Givol D; de Crombrugghe B. 2004. Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype. Genes Dev 18(3):290-305. [PubMed: 14871928] [MGI Ref ID J:88286]
Murchison ND; Price BA; Conner DA; Keene DR; Olson EN; Tabin CJ; Schweitzer R. 2007. Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendons. Development 134(14):2697-708. [PubMed: 17567668] [MGI Ref ID J:122742]
Naiche LA; Papaioannou VE. 2007. Cre activity causes widespread apoptosis and lethal anemia during embryonic development. Genesis 45(12):768-75. [PubMed: 18064676] [MGI Ref ID J:130492]
Naiche LA; Papaioannou VE. 2007. Tbx4 is not required for hindlimb identity or post-bud hindlimb outgrowth. Development 134(1):93-103. [PubMed: 17164415] [MGI Ref ID J:117423]
Ovchinnikov DA; Selever J; Wang Y; Chen YT; Mishina Y; Martin JF; Behringer RR. 2006. BMP receptor type IA in limb bud mesenchyme regulates distal outgrowth and patterning. Dev Biol 295(1):103-15. [PubMed: 16630606] [MGI Ref ID J:144308]
Pan Y; Liu Z; Shen J; Kopan R. 2005. Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis. Dev Biol 286(2):472-82. [PubMed: 16169548] [MGI Ref ID J:103603]
Provot S; Zinyk D; Gunes Y; Kathri R; Le Q; Kronenberg HM; Johnson RS; Longaker MT; Giaccia AJ; Schipani E. 2007. Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development. J Cell Biol 177(3):451-64. [PubMed: 17470636] [MGI Ref ID J:134727]
Pryce BA; Watson SS; Murchison ND; Staverosky JA; Dunker N; Schweitzer R. 2009. Recruitment and maintenance of tendon progenitors by TGF{beta} signaling are essential for tendon formation. Development 136(8):1351-61. [PubMed: 19304887] [MGI Ref ID J:147280]
Raducanu A; Hunziker EB; Drosse I; Aszodi A. 2009. Beta1 integrin deficiency results in multiple abnormalities of the knee joint. J Biol Chem 284(35):23780-92. [PubMed: 19586917] [MGI Ref ID J:153435]
Rallis C; Bruneau BG; Del Buono J; Seidman CE; Seidman JG; Nissim S; Tabin CJ; Logan MP. 2003. Tbx5 is required for forelimb bud formation and continued outgrowth. Development 130(12):2741-51. [PubMed: 12736217] [MGI Ref ID J:83258]
Rock JR; Cecilia Lopez M; Baker HV; Harfe BD. 2007. Identification of genes expressed in the mouse limb using a novel ZPA microarray approach. Gene Expr Patterns 8(1):19-26. [PubMed: 17911046] [MGI Ref ID J:127128]
Schmidt K; Hughes C; Chudek JA; Goodyear SR; Aspden RM; Talbot R; Gundersen TE; Blomhoff R; Henderson C; Wolf CR; Tickle C. 2009. Cholesterol metabolism: the main pathway acting downstream of cytochrome P450 oxidoreductase in skeletal development of the limb. Mol Cell Biol 29(10):2716-29. [PubMed: 19273610] [MGI Ref ID J:148989]
Selever J; Liu W; Lu MF; Behringer RR; Martin JF. 2004. Bmp4 in limb bud mesoderm regulates digit pattern by controlling AER development. Dev Biol 276(2):268-79. [PubMed: 15581864] [MGI Ref ID J:128571]
Seo HS; Serra R. 2007. Deletion of Tgfbr2 in Prx1-cre expressing mesenchyme results in defects in development of the long bones and joints. Dev Biol 310(2):304-16. [PubMed: 17822689] [MGI Ref ID J:128010]
Seo HS; Serra R. 2009. Tgfbr2 is required for development of the skull vault. Dev Biol 334(2):481-90. [PubMed: 19699732] [MGI Ref ID J:153638]
Spagnoli A; O'Rear L; Chandler RL; Granero-Molto F; Mortlock DP; Gorska AE; Weis JA; Longobardi L; Chytil A; Shimer K; Moses HL. 2007. TGF-beta signaling is essential for joint morphogenesis. J Cell Biol 177(6):1105-17. [PubMed: 17576802] [MGI Ref ID J:134924]
Spater D; Hill TP; O'sullivan RJ; Gruber M; Conner DA; Hartmann C. 2006. Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis. Development 133(15):3039-49. [PubMed: 16818445] [MGI Ref ID J:119030]
Tarchini B; Duboule D; Kmita M. 2006. Regulatory constraints in the evolution of the tetrapod limb anterior-posterior polarity. Nature 443(7114):985-8. [PubMed: 17066034] [MGI Ref ID J:114566]
Tsuji K; Bandyopadhyay A; Harfe BD; Cox K; Kakar S; Gerstenfeld L; Einhorn T; Tabin CJ; Rosen V. 2006. BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Nat Genet 38(12):1424-9. [PubMed: 17099713] [MGI Ref ID J:116480]
Vokes SA; Ji H; Wong WH; McMahon AP. 2008. A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb. Genes Dev 22(19):2651-63. [PubMed: 18832070] [MGI Ref ID J:143454]
Yu K; Ornitz DM. 2008. FGF signaling regulates mesenchymal differentiation and skeletal patterning along the limb bud proximodistal axis. Development 135(3):483-91. [PubMed: 18094024] [MGI Ref ID J:130854]
Zelzer E; Mamluk R; Ferrara N; Johnson RS; Schipani E; Olsen BR. 2004. VEGFA is necessary for chondrocyte survival during bone development. Development 131(9):2161-71. [PubMed: 15073147] [MGI Ref ID J:89363]
Zhang Z; Verheyden JM; Hassell JA; Sun X. 2009. FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds. Dev Cell 16(4):607-13. [PubMed: 19386269] [MGI Ref ID J:149477]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX11
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, hemizygous transgenic mice are bred to wildtype siblings. Homozygous mice, reportedly, are viable and fertile. Mating System Hemizygote x +/+ sibling (Female x Male) 18-APR-08 Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $243.50 Female or Male Hemizygous for Tg(Prrx1-cre)1Cjt
Pairs /Price (US dollars $) Pair Genotype $297.85 Hemizygous for Tg(Prrx1-cre)1Cjt x Noncarrier for Tg(Prrx1-cre)1Cjt $297.85 Noncarrier for Tg(Prrx1-cre)1Cjt x Hemizygous for Tg(Prrx1-cre)1Cjt
Additional Supply Details
| Pricing for International shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $316.60 Female or Male Hemizygous for Tg(Prrx1-cre)1Cjt
Pairs /Price (US dollars $) Pair Genotype $387.30 Hemizygous for Tg(Prrx1-cre)1Cjt x Noncarrier for Tg(Prrx1-cre)1Cjt $387.30 Noncarrier for Tg(Prrx1-cre)1Cjt x Hemizygous for Tg(Prrx1-cre)1Cjt
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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