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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Former Names B6.129S-Shhtm1(EGFP/cre)Cjt/J (Changed: 05-SEP-06 ) Type Congenic; Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System +/+ sibling x Heterozygote (Female x Male) 29-DEC-06 Species laboratory mouse Generation N6F11 (16-FEB-11)
Generation DefinitionsDonating Investigator Clifford Tabin, Harvard Medical School Description
This strain expresses a fusion product involving Enhanced Green Fluorescent Protein (EGFP) and Cre recombinase from the endogenous Shh locus. EGFP and cre expression are consistent with the endogenous gene. Fluorescence is detected in the distal posterior region of the limb buds of embryos aged embryonic day 10 to 12 and colocalizes with the endogenous gene product (mRNA). The donating investigator reports that it is not uncommon for a mosaic expression pattern to be exhibited when the allele is inherited through the female germline. It is recommended that this allele be passed through the male germline when conducting experiments involving cre-induced recombination. Mice homozygous for the mutation develop a limited limb skeleton and lack digit 2. Homozygous mice are not viable or fertile. Heterozygous mutant mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. This mutant mouse strain may be useful in studies of limb patterning and development.Development
A targeting vector containing a fusion product involving Enhanced Green Fluorescent Protein (EGFP) and Cre recombinase was inserted at the ATG of Shh and disrupted the sequence encoding the first 12 amino acids. The construct was electroporated into 129S6/SvEv-derived TC-1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts. The resulting chimeric animals were crossed to C57BL/6 mice, and the donating investigator reported that they were then backcrossed to the same for at least 5 generations.A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, all 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to The Jackson Laboratory Repository were on a C57BL/6N genetic background.
Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Fluorescent Protein Strains
View Fluorescent Protein Strains (345 strains)
000214 B10.D2/nSn-ShhHx/J 005623 B6.129S6-Shhtm2(cre/ERT2)Cjt/J 008466 B6.129X1(Cg)-Shhtm6Amc/J 004293 B6;129-Shhtm2Amc/J 011031 B6;129S4-Shhtm1.1Rseg/J 003318 STOCK Shhtm1Amc/J
Additional Web Information
Fluorescent Proteins/lacZ Systems
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Shhtm1(EGFP/cre)Cjt/Shhtm1(EGFP/cre)Cjt
Background Not Specified
- limbs/digits/tail phenotype
- abnormal limb bone morphology
- a limited skeletal structure consisting of the humerus, radius and single digit 1 is seen (MGI Ref ID J:92504)
- skeleton phenotype
- abnormal limb bone morphology
- a limited skeletal structure consisting of the humerus, radius and single digit 1 is seen (MGI Ref ID J:92504)
This mouse can be used to support research in many areas including:
GFP relatedDevelopmental Biology Research
Embryonic Lethality (Homozygous)
Limb Patterning Defects
Skeletal Defects
Research Tools
Cre-lox System
Cre Recombinase Expression
Cre Recombinase Expression: Germline/Embryonic Expression
Developmental Biology Research
Cre-lox System
Fluorescent Proteins
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
cre relatedResearch Tools
Fluorescent Proteins
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Shhtm1(EGFP/cre)Cjt | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Clifford J Tabin | ||
| Allele Type | Targeted (knock-in) | ||
| Common Name(s) | Shh-GFP-Cre; Shh-cre; ShhCreEGFP; ShhGFP-Cre; Shhcre/Gfp; Shhgfpcre; Shhgfp-Cre; Shhgfpcre; | ||
| Mutation Made By | Clifford Tabin, Harvard Medical School | ||
| Site of Expression | Distal posterior region of the limb buds of embryos aged embryonic day 10 to 12; also a Cre strain. | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Expressed Gene | GFP, Green Fluorescent Protein, jellyfish | ||
| Green Fluorescent Protein (GFP), derived from the jellyfish Aequorea victoria, is a versatile reporter molecule which has found use in many biological applications. In some constructs the original molecule has been modified in order to enhance its fluorescence intensity (EGFP, enhanced GFP). When utilized in a transgenic construct, tissue expressing sufficient amounts of GFP will fluoresce when exposed to a 488 nm light source. | |||
| Driver Note | Shh | ||
| Molecular Note | A cassette containing an in frame fusion between GFP and cre was inserted at the ATG. Upon recombination, the first 35 base pairs after the ATG were deleted. Fluorescence was detected in the distal posterior region of E10-E12 embryos. [MGI Ref ID J:92504] | ||
| Gene Symbol and Name | Shh, sonic hedgehog | ||
| Chromosome | 5 | ||
| Gene Common Name(s) | Dsh; HHG1; HLP3; HPE3; Hhg1; Hx; Hxl3; M100081; MCOPCB5; SMMCI; TPT; TPTPS; hedgehog gene 1; hemimelic extra toes; hemimelic extratoes like 3; short digits; | ||
Genotyping
Genotyping Information
Genotyping Protocols
Shh tm1(EGFP/cre)Cjt, Melt Curve Analysis
Shhtm1(EGFP/cre)Cjt, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Harfe BD; Scherz PJ; Nissim S; Tian H; McMahon AP; Tabin CJ. 2004. Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell 118(4):517-28. [PubMed: 15315763] [MGI Ref ID J:92504]
Additional References
Shhtm1(EGFP/cre)Cjt relatedAhn Y; Sanderson BW; Klein OD; Krumlauf R. 2010. Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning. Development 137(19):3221-31. [PubMed: 20724449] [MGI Ref ID J:168361]
Bell SM; Zhang L; Mendell A; Xu Y; Haitchi HM; Lessard JL; Whitsett JA. 2011. Kruppel-like factor 5 is required for formation and differentiation of the bladder urothelium. Dev Biol 358(1):79-90. [PubMed: 21803035] [MGI Ref ID J:176604]
Chamberlain CE; Jeong J; Guo C; Allen BL; McMahon AP. 2008. Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning. Development 135(6):1097-106. [PubMed: 18272593] [MGI Ref ID J:132152]
Choi KS; Harfe BD. 2011. Hedgehog signaling is required for formation of the notochord sheath and patterning of nuclei pulposi within the intervertebral discs. Proc Natl Acad Sci U S A 108(23):9484-9. [PubMed: 21606373] [MGI Ref ID J:173333]
Croyle MJ; Lehman JM; O'Connor AK; Wong SY; Malarkey EB; Iribarne D; Dowdle WE; Schoeb TR; Verney ZM; Athar M; Michaud EJ; Reiter JF; Yoder BK. 2011. Role of epidermal primary cilia in the homeostasis of skin and hair follicles. Development 138(9):1675-85. [PubMed: 21429982] [MGI Ref ID J:171221]
Domyan ET; Ferretti E; Throckmorton K; Mishina Y; Nicolis SK; Sun X. 2011. Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2. Development 138(5):971-81. [PubMed: 21303850] [MGI Ref ID J:169134]
Flandin P; Kimura S; Rubenstein JL. 2010. The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons. J Neurosci 30(8):2812-23. [PubMed: 20181579] [MGI Ref ID J:157830]
Glotzer DJ; Zelzer E; Olsen BR. 2008. Impaired skin and hair follicle development in Runx2 deficient mice. Dev Biol 315(2):459-73. [PubMed: 18262513] [MGI Ref ID J:132568]
Goss AM; Tian Y; Tsukiyama T; Cohen ED; Zhou D; Lu MM; Yamaguchi TP; Morrisey EE. 2009. Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut. Dev Cell 17(2):290-8. [PubMed: 19686689] [MGI Ref ID J:153098]
Gritli-Linde A; Hallberg K; Harfe BD; Reyahi A; Kannius-Janson M; Nilsson J; Cobourne MT; Sharpe PT; McMahon AP; Linde A. 2007. Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling. Dev Cell 12(1):99-112. [PubMed: 17199044] [MGI Ref ID J:117334]
Haara O; Fujimori S; Schmidt-Ullrich R; Hartmann C; Thesleff I; Mikkola ML. 2011. Ectodysplasin and Wnt pathways are required for salivary gland branching morphogenesis. Development 138(13):2681-91. [PubMed: 21652647] [MGI Ref ID J:173573]
Harfe BD; McManus MT; Mansfield JH; Hornstein E; Tabin CJ. 2005. The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci U S A 102(31):10898-903. [PubMed: 16040801] [MGI Ref ID J:100475]
Harris KS; Zhang Z; McManus MT; Harfe BD; Sun X. 2006. Dicer function is essential for lung epithelium morphogenesis. Proc Natl Acad Sci U S A 103(7):2208-13. [PubMed: 16452165] [MGI Ref ID J:106072]
Ishida K; Murofushi M; Nakao K; Morita R; Ogawa M; Tsuji T. 2011. The regulation of tooth morphogenesis is associated with epithelial cell proliferation and the expression of Sonic hedgehog through epithelial-mesenchymal interactions. Biochem Biophys Res Commun 405(3):455-61. [PubMed: 21255557] [MGI Ref ID J:170606]
Joksimovic M; Yun BA; Kittappa R; Anderegg AM; Chang WW; Taketo MM; McKay RD; Awatramani RB. 2009. Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis. Nat Neurosci 12(2):125-31. [PubMed: 19122665] [MGI Ref ID J:146200]
Joo JH; Taxter TJ; Munguba GC; Kim YH; Dhaduvai K; Dunn NW; Degan WJ; Oh SP; Sugrue SP. 2010. Pinin modulates expression of an intestinal homeobox gene, Cdx2, and plays an essential role for small intestinal morphogenesis. Dev Biol 345(2):191-203. [PubMed: 20637749] [MGI Ref ID J:164807]
Kim BM; Mao J; Taketo MM; Shivdasani RA. 2007. Phases of canonical Wnt signaling during the development of mouse intestinal epithelium. Gastroenterology 133(2):529-38. [PubMed: 17681174] [MGI Ref ID J:128278]
Kim BM; Miletich I; Mao J; McMahon AP; Sharpe PA; Shivdasani RA. 2007. Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen. Development 134(20):3603-13. [PubMed: 17855428] [MGI Ref ID J:128378]
King P; Paul A; Laufer E. 2009. Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages. Proc Natl Acad Sci U S A 106(50):21185-90. [PubMed: 19955443] [MGI Ref ID J:155826]
Kittappa R; Chang WW; Awatramani RB; McKay RD. 2007. The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. PLoS Biol 5(12):e325. [PubMed: 18076286] [MGI Ref ID J:130846]
Lahti L; Saarimaki-Vire J; Rita H; Partanen J. 2011. FGF signaling gradient maintains symmetrical proliferative divisions of midbrain neuronal progenitors. Dev Biol 349(2):270-82. [PubMed: 21074523] [MGI Ref ID J:168023]
Lin C; Fisher AV; Yin Y; Maruyama T; Veith GM; Dhandha M; Huang GJ; Hsu W; Ma L. 2011. The inductive role of Wnt-beta-Catenin signaling in the formation of oral apparatus. Dev Biol 356(1):40-50. [PubMed: 21600200] [MGI Ref ID J:175262]
Lin C; Yin Y; Long F; Ma L. 2008. Tissue-specific requirements of beta-catenin in external genitalia development. Development 135(16):2815-25. [PubMed: 18635608] [MGI Ref ID J:139251]
Lin C; Yin Y; Veith GM; Fisher AV; Long F; Ma L. 2009. Temporal and spatial dissection of Shh signaling in genital tubercle development. Development 136(23):3959-67. [PubMed: 19906863] [MGI Ref ID J:158288]
Liu Z; Owen T; Zhang L; Zuo J. 2010. Dynamic expression pattern of Sonic hedgehog in developing cochlear spiral ganglion neurons. Dev Dyn 239(6):1674-83. [PubMed: 20503364] [MGI Ref ID J:160591]
Maier JA; Harfe BD. 2011. Nuclei Pulposi Formation From the Embryonic Notochord Occurs Normally in GDF-5-Deficient Mice. Spine (Phila Pa 1976) 36(24):E1555-61. [PubMed: 21278629] [MGI Ref ID J:178272]
Mao J; Kim BM; Rajurkar M; Shivdasani RA; McMahon AP. 2010. Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract. Development 137(10):1721-9. [PubMed: 20430747] [MGI Ref ID J:160363]
Munne PM; Tummers M; Jarvinen E; Thesleff I; Jernvall J. 2009. Tinkering with the inductive mesenchyme: Sostdc1 uncovers the role of dental mesenchyme in limiting tooth induction. Development 136(3):393-402. [PubMed: 19141669] [MGI Ref ID J:144193]
Omori A; Harada M; Ohta S; Villacorte M; Sugimura Y; Shiraishi T; Suzuki K; Nakagata N; Ito T; Yamada G. 2011. Epithelial Bmp (Bone morphogenetic protein) signaling for bulbourethral gland development: a mouse model for congenital cystic dilation. Congenit Anom (Kyoto) 51(3):102-9. [PubMed: 21848994] [MGI Ref ID J:176595]
Prochazka J; Pantalacci S; Churava S; Rothova M; Lambert A; Lesot H; Klein O; Peterka M; Laudet V; Peterkova R. 2010. Patterning by heritage in mouse molar row development. Proc Natl Acad Sci U S A 107(35):15497-502. [PubMed: 20709958] [MGI Ref ID J:163666]
Rock JR; Cecilia Lopez M; Baker HV; Harfe BD. 2007. Identification of genes expressed in the mouse limb using a novel ZPA microarray approach. Gene Expr Patterns 8(1):19-26. [PubMed: 17911046] [MGI Ref ID J:127128]
Rodriguez P; Da Silva S; Oxburgh L; Wang F; Hogan BL; Que J. 2010. BMP signaling in the development of the mouse esophagus and forestomach. Development 137(24):4171-6. [PubMed: 21068065] [MGI Ref ID J:166768]
Sanchez-Camacho C; Bovolenta P. 2008. Autonomous and non-autonomous Shh signalling mediate the in vivo growth and guidance of mouse retinal ganglion cell axons. Development 135(21):3531-41. [PubMed: 18832395] [MGI Ref ID J:143442]
Seifert AW; Bouldin CM; Choi KS; Harfe BD; Cohn MJ. 2009. Multiphasic and tissue-specific roles of sonic hedgehog in cloacal septation and external genitalia development. Development 136(23):3949-57. [PubMed: 19906862] [MGI Ref ID J:154980]
Seifert AW; Yamaguchi T; Cohn MJ. 2009. Functional and phylogenetic analysis shows that Fgf8 is a marker of genital induction in mammals but is not required for external genital development. Development 136(15):2643-51. [PubMed: 19592577] [MGI Ref ID J:158139]
Tang M; Miyamoto Y; Huang EJ. 2009. Multiple roles of {beta}-catenin in controlling the neurogenic niche for midbrain dopamine neurons. Development 136(12):2027-38. [PubMed: 19439492] [MGI Ref ID J:149534]
Tang M; Villaescusa JC; Luo SX; Guitarte C; Lei S; Miyamoto Y; Taketo MM; Arenas E; Huang EJ. 2010. Interactions of Wnt/beta-catenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neurons. J Neurosci 30(27):9280-91. [PubMed: 20610763] [MGI Ref ID J:161771]
Tang N; Marshall WF; McMahon M; Metzger RJ; Martin GR. 2011. Control of mitotic spindle angle by the RAS-regulated ERK1/2 pathway determines lung tube shape. Science 333(6040):342-5. [PubMed: 21764747] [MGI Ref ID J:174194]
Tian H; Jeong J; Harfe BD; Tabin CJ; McMahon AP. 2005. Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand. Development 132(1):133-42. [PubMed: 15576405] [MGI Ref ID J:94270]
Town L; McGlinn E; Fiorenza S; Metzis V; Butterfield NC; Richman JM; Wicking C. 2009. The metalloendopeptidase gene Pitrm1 is regulated by hedgehog signaling in the developing mouse limb and is expressed in muscle progenitors. Dev Dyn 238(12):3175-3184. [PubMed: 19877269] [MGI Ref ID J:154373]
Tsao PN; Wei SC; Wu MF; Huang MT; Lin HY; Lee MC; Lin KM; Wang IJ; Kaartinen V; Yang LT; Cardoso WV. 2011. Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development. Development 138(16):3533-43. [PubMed: 21791528] [MGI Ref ID J:175774]
Varnat F; Zacchetti G; Ruiz I Altaba A. 2010. Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling. Mech Dev 127(1-2):73-81. [PubMed: 19861162] [MGI Ref ID J:156736]
Verheyden JM; Lewandoski M; Deng C; Harfe BD; Sun X. 2005. Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning. Development 132(19):4235-45. [PubMed: 16120640] [MGI Ref ID J:101736]
Yan CH; Levesque M; Claxton S; Johnson RL; Ang SL. 2011. Lmx1a and lmx1b function cooperatively to regulate proliferation, specification, and differentiation of midbrain dopaminergic progenitors. J Neurosci 31(35):12413-25. [PubMed: 21880902] [MGI Ref ID J:176226]
Yin Y; Wang F; Ornitz DM. 2011. Mesothelial- and epithelial-derived FGF9 have distinct functions in the regulation of lung development. Development 138(15):3169-77. [PubMed: 21750028] [MGI Ref ID J:175543]
Yun S; Saijoh Y; Hirokawa KE; Kopinke D; Murtaugh LC; Monuki ES; Levine EM. 2009. Lhx2 links the intrinsic and extrinsic factors that control optic cup formation. Development 136(23):3895-906. [PubMed: 19906857] [MGI Ref ID J:154982]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX11
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, these mice are bred as heterozygotes. Homozygous mice are not viable. Mating System +/+ sibling x Heterozygote (Female x Male) 29-DEC-06 Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Live Mice
Price (US dollars $) Gender Genotypes Provided Individual Mouse $261.00 Female or Male Heterozygous for Shhtm1(EGFP/cre)Cjt
Pairs /Price (US dollars $) Pair Genotype $321.00 Heterozygous for Shhtm1(EGFP/cre)Cjt x Wild-type for Shhtm1(EGFP/cre)Cjt $321.00 Wild-type for Shhtm1(EGFP/cre)Cjt x Heterozygous for Shhtm1(EGFP/cre)Cjt Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
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Live Mice
Price (US dollars $) Gender Genotypes Provided Individual Mouse $339.30 Female or Male Heterozygous for Shhtm1(EGFP/cre)Cjt
Pairs /Price (US dollars $) Pair Genotype $417.30 Heterozygous for Shhtm1(EGFP/cre)Cjt x Wild-type for Shhtm1(EGFP/cre)Cjt $417.30 Wild-type for Shhtm1(EGFP/cre)Cjt x Heterozygous for Shhtm1(EGFP/cre)Cjt Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
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|
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Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
General Supply Notes
- This strain is included in the Induced Mutant Resource Colony collection.
Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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