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Common Names: Emx1IRES cre;    
Emx1-IRES-Cre knockin mice have the endogenous Emx1 locus directing expression of Cre recombinase to approximately 88% of the neurons of the neocortex and hippocampus, and in the glial cells of the pallium. These mice are useful in studies of forebrain development and function.


Strain Information

Former Names B6.Cg-Emx1tm1(cre)Krj/J    (Changed: 27-MAR-08 )
B6.129-Emx1tm1(cre)Krj/J    (Changed: 27-MAR-08 )
Type Congenic; Targeted Mutation;
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Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   02-NOV-06
Specieslaboratory mouse
GenerationN12+N2F6 (05-MAY-15)
Generation Definitions
Donating Investigator Kevin R. Jones,   University of Colorado- Boulder

Mice homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. This strain expresses Cre recombinase from the endogenous Emx1 locus. Western blot analysis of cortical brain tissue does not detect reduced endogenous gene product (protein). When crossed with a strain containing a loxP-site flanked sequence, Cre-mediated recombination results in tissue-specific deletion of the flanked sequence. Recombination occurs in approximately 88% of the neurons of the neocortex and hippocampus, and in the glial cells of the pallium, mimicking the pattern of expression of the endogenous gene. Further, the donating investigator reports that Cre recombinase is also expressed in a subset of male germline cells, thus some offspring from a cre; floxed male will have the floxed allele recombined in all cells. Our findings suggest that females may also be similarly affected. This mutant mouse strain represents a model that may be useful in studies of forebrain development and function.

View cre expression characterization.

A targeting vector containing an internal ribosome entry site (IRES) sequence, Cre coding sequence, a polyadenlyation signal and a FRT site flanked PGK-neomycin cassette was inserted 120bp 3' from the stop codon, in the 3' untranslated region. The construct was electroporated into 129S2/SvPas derived D3 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts. The resulting chimeric animal was crossed to a Flp recombinase expressing strain (FLP-4917) to remove the selection cassette. The mice were then backcrossed to C57BL/6 mice for 12 generations.

Control Information

   000664 C57BL/6J
  Considerations for Choosing Controls

Related Strains

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022762   B6.Cg-Zfp335tm1.2Caw Emx1tm1(cre)Krj/J
View Strains carrying   Emx1tm1(cre)Krj     (1 strain)

Strains carrying other alleles of Emx1
003080   B6;129X1-Emx1tm1Jlr/J
View Strains carrying other alleles of Emx1     (1 strain)

Strains carrying other alleles of cre
004337   129(Cg)-Foxg1tm1(cre)Skm/J
008569   129-Alpltm1(cre)Nagy/J
005989   129;FVB-Tg(PTH-cre)4167Slib/J
007179   129S.Cg-Tg(UBC-cre/ERT2)1Ejb/J
007915   129S.FVB-Tg(Amh-cre)8815Reb/J
003328   129S/Sv-Tg(Prm-cre)58Og/J
026200   129S1.Cg-Tg(Vsx2-cre)2690Chow/J
004302   129S1/Sv-Hprttm1(cre)Mnn/J
022137   129S4.Cg-Tg(Wnt1-cre)2Sor/J
003960   129S6-Tg(Prnp-GFP/cre)1Blw/J
008523   129S6.Cg-Tg(NPHS2-cre)295Lbh/BroJ
009587   B6(129S4)-Et(icre)1402Rdav/J
009588   B6(129S4)-Et(icre)1470Rdav/J
009589   B6(129S4)-Et(icre)1555Rdav/J
009586   B6(129S4)-Et(icre)754Rdav/J
012687   B6(129S4)-Tg(SYN1-icre/mRFP1)9934Rdav/J
010774   B6(Cg)-Calb2tm1(cre)Zjh/J
017562   B6(Cg)-Cd8atm1.1(cre)Koni/J
012704   B6(Cg)-Crhtm1(cre)Zjh/J
018448   B6(Cg)-Foxn1tm3(cre)Nrm/J
026801   B6(Cg)-Ins1tm1.1(cre)Thor/J
016223   B6(Cg)-Tg(Phox2b-cre)3Jke/J
016959   B6.129(Cg)-Foxp3tm4(YFP/cre)Ayr/J
023055   B6.129(Cg)-Krt12tm3(cre)Wwk/J
008320   B6.129-Leprtm2(cre)Rck/J
017526   B6.129-Nos1tm1(cre)Mgmj/J
005697   B6.129-Otx1tm4(cre)Asim/J
018938   B6.129-Tac2tm1.1(cre)Qima/J
017769   B6.129-Trpv1tm1(cre)Bbm/J
004146   B6.129-Tg(Pcp2-cre)2Mpin/J
008710   B6.129P2(129S4)-Hprttm10(Ple162-EGFP/cre)Ems/Mmjax
008877   B6.129P2(129S4)-Hprttm12(Ple177-EGFP/cre)Ems/Mmjax
009116   B6.129P2(129S4)-Hprttm16(Ple167-EGFP/cre)Ems/Mmjax
008709   B6.129P2(129S4)-Hprttm9(Ple178-EGFP/cre)Ems/Mmjax
006785   B6.129P2(C)-Cd19tm1(cre)Cgn/J
006084   B6.129P2(Cg)-Foxg1tm1(cre)Skm/J
010611   B6.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
007770   B6.129P2-Aicdatm1(cre)Mnz/J
004781   B6.129P2-Lyz2tm1(cre)Ifo/J
017320   B6.129P2-Pvalbtm1(cre)Arbr/J
017915   B6.129S(Cg)-Pgrtm1.1(cre)Shah/AndJ
013594   B6.129S-Atoh1tm5.1(Cre/PGR)Hzo/J
021794   B6.129S1(Cg)-Ascl3tm1.1(EGFP/cre)Ovi/J
024637   B6.129S1(SJL)-Nkx2-5tm2(cre)Rph/J
006600   B6.129S1-Mnx1tm4(cre)Tmj/J
022510   B6.129S4-Gpr88tm1.1(cre/GFP)Rpa/J
017578   B6.129S4-Mcpt8tm1(cre)Lky/J
003755   B6.129S4-Meox2tm1(cre)Sor/J
007893   B6.129S4-Myf5tm3(cre)Sor/J
006878   B6.129S6-Taglntm2(cre)Yec/J
012839   B6.129X1(Cg)-Tnfrsf4tm2(cre)Nik/J
008712   B6.129X1-Twist2tm1.1(cre)Dor/J
006054   B6.C-Tg(CMV-cre)1Cgn/J
020811   B6.C-Tg(Pgk1-cre)1Lni/CrsJ
023530   B6.Cg-Avptm1.1(cre)Hze/J
013590   B6.Cg-Braftm1Mmcm Ptentm1Hwu Tg(Tyr-cre/ERT2)13Bos/BosJ
006230   B6.Cg-Cebpatm1Dgt Tg(Mx1-cre)1Cgn/J
012358   B6.Cg-Pvalbtm1.1(cre)Aibs/J
005622   B6.Cg-Shhtm1(EGFP/cre)Cjt/J
017346   B6.Cg-Tg(A930038C07Rik-cre)1Aibs/J
006149   B6.Cg-Tg(ACTA1-cre)79Jme/J
003574   B6.Cg-Tg(Alb-cre)21Mgn/J
006881   B6.Cg-Tg(Aqp2-cre)1Dek/J
011104   B6.Cg-Tg(Atoh1-cre)1Bfri/J
008520   B6.Cg-Tg(CD2-cre)4Kio/J
009350   B6.Cg-Tg(CDX2-cre)101Erf/J
009352   B6.Cg-Tg(CDX2-cre*)189Erf/J
027310   B6.Cg-Tg(Camk2a-cre)2Szi/J
027400   B6.Cg-Tg(Camk2a-cre)3Szi/J
005359   B6.Cg-Tg(Camk2a-cre)T29-1Stl/J
022071   B6.Cg-Tg(Cd4-cre)1Cwi/BfluJ
012237   B6.Cg-Tg(Cdh16-cre)91Igr/J
006368   B6.Cg-Tg(Cr2-cre)3Cgn/J
006663   B6.Cg-Tg(Eno2-cre)39Jme/J
005069   B6.Cg-Tg(Fabp4-cre)1Rev/J
012712   B6.Cg-Tg(Fev-cre)1Esd/J
012849   B6.Cg-Tg(GFAP-cre/ERT2)505Fmv/J
012886   B6.Cg-Tg(Gfap-cre)73.12Mvs/J
024098   B6.Cg-Tg(Gfap-cre)77.6Mvs/2J
009642   B6.Cg-Tg(Gh1-cre)1Sac/J
024474   B6.Cg-Tg(Il9-cre)#Stck/J
003573   B6.Cg-Tg(Ins2-cre)25Mgn/J
008068   B6.Cg-Tg(Itgax-cre)1-1Reiz/J
008781   B6.Cg-Tg(Kap-cre)29066/2Sig/J
003802   B6.Cg-Tg(Lck-cre)548Jxm/J
006889   B6.Cg-Tg(Lck-cre)I540Jxm/J
012837   B6.Cg-Tg(Lck-icre)3779Nik/J
009643   B6.Cg-Tg(Lhb-cre)1Sac/J
008330   B6.Cg-Tg(Mc4r-cre)25Rck/J
003556   B6.Cg-Tg(Mx1-cre)1Cgn/J
007742   B6.Cg-Tg(Myh11-cre,-EGFP)2Mik/J
008205   B6.Cg-Tg(NPHS2-cre)295Lbh/J
003771   B6.Cg-Tg(Nes-cre)1Kln/J
010536   B6.Cg-Tg(Pcp2-cre)3555Jdhu/J
005975   B6.Cg-Tg(Plp1-cre/ERT)3Pop/J
008827   B6.Cg-Tg(Prdm1-cre)1Masu/J
005584   B6.Cg-Tg(Prrx1-cre)1Cjt/J
003967   B6.Cg-Tg(Rbp3-cre)528Jxm/J
021614   B6.Cg-Tg(S100A8-cre,-EGFP)1Ilw/J
008454   B6.Cg-Tg(Sox2-cre)1Amc/J
006361   B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/J
003966   B6.Cg-Tg(Syn1-cre)671Jxm/J
017491   B6.Cg-Tg(Tagln-cre)1Her/J
004128   B6.Cg-Tg(Tek-cre)12Flv/J
008863   B6.Cg-Tg(Tek-cre)1Ywa/J
008601   B6.Cg-Tg(Th-cre)1Tmd/J
012328   B6.Cg-Tg(Tyr-cre/ERT2)13Bos/J
008085   B6.Cg-Tg(UBC-cre/ERT2)1Ejb/J
008610   B6.Cg-Tg(Vav1-cre)A2Kio/J
004586   B6.Cg-Tg(Vil-cre)997Gum/J
021504   B6.Cg-Tg(Vil1-cre)1000Gum/J
008735   B6.Cg-Tg(Wap-cre)11738Mam/JKnwJ
009614   B6.Cg-Tg(Wfs1-cre/ERT2)2Aibs/J
009107   B6.Cg-Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
022501   B6.Cg-Tg(Wnt1-cre)2Sor/J
006234   B6.Cg-Tg(tetO-cre)1Jaw/J
016832   B6.FVB(129)-Tg(Alb1-cre)1Dlr/J
005657   B6.FVB(129)-Tg(Myh6-cre/Esr1*)1Jmk/J
024688   B6.FVB(129S)-Tg(Pax6-GFP/cre)1Rilm/J
006475   B6.FVB(129S4)-Tg(Ckmm-cre)5Khn/J
006451   B6.FVB(129X1)-Tg(Sim1-cre)1Lowl/J
006333   B6.FVB(Cg)-Tg(Neurog3-cre)C1Able/J
014643   B6.FVB-Tg(CMA1-cre)6Thhe/J
006137   B6.FVB-Tg(Cdh5-cre)7Mlia/J
018980   B6.FVB-Tg(Ddx4-cre)1Dcas/KnwJ
003724   B6.FVB-Tg(EIIa-cre)C5379Lmgd/J
011069   B6.FVB-Tg(Gh1-cre)bKnmn/J
011038   B6.FVB-Tg(Myh6-cre)2182Mds/J
014647   B6.FVB-Tg(Pdx1-cre)6Tuv/J
010714   B6.FVB-Tg(Pomc-cre)1Lowl/J
022791   B6.FVB-Tg(Rorc-cre)1Litt/J
017535   B6.FVB-Tg(Slc32a1-cre)2.1Hzo/FrkJ
017490   B6.FVB-Tg(Stra8-icre)1Reb/LguJ
024670   B6.FVB-Tg(Ucp1-cre)1Evdr/J
003394   B6.FVB-Tg(Zp3-cre)3Mrt/J
006660   B6.SJL-Slc6a3tm1.1(cre)Bkmn/J
003552   B6129-Tg(Wap-cre)11738Mam/J
023161   B6129S-Tg(Foxp3-EGFP/cre)1aJbs/J
021025   B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-cre)Haho/J
010529   B6;129-Myf5tm1(cre)Mrc/J
010528   B6;129-Myf6tm2(cre)Mrc/J
017525   B6;129-Ntstm1(cre)Mgmj/J
005549   B6;129-Pax3tm1(cre)Joe/J
017968   B6;129-Tg(Cdh5-cre)1Spe/J
024860   B6;129-Tg(Drd1-cre)120Mxu/Mmjax
010988   B6;129P-Cyp11a1tm1(GFP/cre)Pzg/J
008529   B6;129P-Tg(Neurog1-cre/ERT2)1Good/J
012601   B6;129P2-Lyve1tm1.1(EGFP/cre)Cys/J
006668   B6;129P2-Omptm4(cre)Mom/MomJ
008069   B6;129P2-Pvalbtm1(cre)Arbr/J
012373   B6;129S-Hoxb1tm1(cre)Og/J
024234   B6;129S-Oxttm1.1(cre)Dolsn/J
023526   B6;129S-Rorbtm1.1(cre)Hze/J
023527   B6;129S-Slc17a7tm1.1(cre)Hze/J
023525   B6;129S-Snap25tm2.1(cre)Hze/J
021877   B6;129S-Tac1tm1.1(cre)Hze/J
021878   B6;129S-Tac2tm1.1(cre)Hze/J
017685   B6;129S-Wisp3tm1(cre)Mawa/J
007001   B6;129S-Tg(UBC-cre/ERT2)1Ejb/J
009388   B6;129S1-Osr2tm2(cre)Jian/J
012463   B6;129S4-Foxd1tm1(GFP/cre)Amc/J
011105   B6;129S4-Olig1tm1(cre)Rth/J
006410   B6;129S6-Chattm2(cre)Lowl/J
009616   B6;C3-Tg(A930038C07Rik-cre)4Aibs/J
012433   B6;C3-Tg(ACTA1-rtTA,tetO-cre)102Monk/J
008844   B6;C3-Tg(Ctgf-cre)2Aibs/J
008839   B6;C3-Tg(Cyp39a1-cre)1Aibs/J
009117   B6;C3-Tg(Cyp39a1-cre)7Aibs/J
008848   B6;C3-Tg(Mybpc1-cre)2Aibs/J
009111   B6;C3-Tg(Scnn1a-cre)1Aibs/J
009112   B6;C3-Tg(Scnn1a-cre)2Aibs/J
009613   B6;C3-Tg(Scnn1a-cre)3Aibs/J
009103   B6;C3-Tg(Wfs1-cre/ERT2)3Aibs/J
025806   B6;CBA-Tg(Gsx2-cre)1Kess/J
026555   B6;CBA-Tg(Lhx6-cre)1Kess/J
025807   B6;CBA-Tg(Sox10-cre)1Wdr/J
024507   B6;CBA-Tg(Tbx21-cre)1Dlc/J
017494   B6;D-Tg(Tshz3-GFP/cre)43Amc/J
024926   B6;D2-Tg(Fshr-cre)1Ldu/J
003466   B6;D2-Tg(Sycp1-cre)4Min/J
014160   B6;DBA-Tg(S100b-EGFP/cre/ERT2)22Amc/J
014159   B6;DBA-Tg(Tmem100-EGFP/cre/ERT2)30Amc/J
015855   B6;DBA-Tg(Upk3a-GFP/cre/ERT2)26Amc/J
010803   B6;FVB-Tg(Adipoq-cre)1Evdr/J
018422   B6;FVB-Tg(Aicda-cre)1Rcas/J
023748   B6;FVB-Tg(Aldh1l1-cre)JD1884Gsat/J
011087   B6;FVB-Tg(Crh-cre)1Kres/J
008533   B6;FVB-Tg(Cspg4-cre)1Akik/J
003734   B6;FVB-Tg(GZMB-cre)1Jcb/J
015850   B6;SJL-Pde6b+ Tg(Rho-icre)1Ck/Boc
004426   B6;SJL-Tg(Cga-cre)3Sac/J
003554   B6;SJL-Tg(Col2a1-cre)1Bhr/J
017738   B6;SJL-Tg(Foxl1-cre)1Khk/J
005249   B6;SJL-Tg(Krt1-15-cre/PGR)22Cot/J
019893   B6;SJL-Tg(Tex101-icre)2Lzj/J
007252   B6Ei.129S4-Tg(Prm-cre)58Og/EiJ
025524   B6J.B6N(Cg)-Cx3cr1tm1.1(cre)Jung/J
018956   B6N.129P2(B6)-Lyz2tm1(cre)Ifo/J
018958   B6N.129P2-Cd19tm1(cre)Cgn/J
021077   B6N.129S1-Mrgprb4tm3(cre)And/J
018957   B6N.129S6(B6)-Chattm2(cre)Lowl/J
017911   B6N.129S6(Cg)-Esr1tm1.1(cre)And/J
019013   B6N.129S6(Cg)-Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
018974   B6N.B6-Tg(Nr4a1-EGFP/cre)820Khog/J
019021   B6N.Cg-Ccktm1.1(cre)Zjh/J
019022   B6N.Cg-Gad2tm2(cre)Zjh/J
018973   B6N.Cg-Ssttm2.1(cre)Zjh/J
018961   B6N.Cg-Tg(Alb-cre)21Mgn/J
018966   B6N.Cg-Tg(Camk2a-cre)T29-1Stl/J
018965   B6N.Cg-Tg(Fabp4-cre)1Rev/J
017310   B6N.Cg-Tg(Hsd17b1-icre/ERT2)3Casa/J
018960   B6N.Cg-Tg(Ins2-cre)25Mgn/J
018967   B6N.Cg-Tg(Itgax-cre)1-1Reiz/J
018964   B6N.Cg-Tg(KRT14-cre)1Amc/J
019103   B6N.Cg-Tg(Nes-cre)1Kln/CjDswJ
014094   B6N.Cg-Tg(Sox2-cre)1Amc/J
018968   B6N.Cg-Tg(Vav1-cre)A2Kio/J
018963   B6N.Cg-Tg(Vil-cre)997Gum/J
018972   B6N.FVB(B6)-Tg(Myh6-cre)2182Mds/J
019099   B6N.FVB-Tg(ACTB-cre)2Mrt/CjDswJ
019509   B6N.FVB-Tg(BGLAP-cre)1Clem/J
023047   B6N.FVB-Tg(Dmp1-cre)1Jqfe/BwdJ
017927   B6N.FVB-Tg(Mpz-cre)26Mes/J
003465   BALB/c-Tg(CMV-cre)1Cgn/J
012641   BALB/c-Tg(S100a4-cre)1Egn/YunkJ
010612   C.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
017353   C.129S4(B6)-Il13tm1(YFP/cre)Lky/J
017582   C.129S4(B6)-Mcpt8tm1(cre)Lky/J
004126   C.Cg-Cd19tm1(cre)Cgn Ighb/J
005673   C.Cg-Tg(Mx1-cre)1Cgn/J
006244   C.Cg-Tg(tetO-cre)1Jaw/J
009155   C57BL/6-Cldn6tm1(cre)Dkwu/J
017557   C57BL/6-Tg(BEST1-cre)1Jdun/J
027406   C57BL/6-Tg(CD2-cre)1Lov/J
016097   C57BL/6-Tg(Car1-cre)5Flt/J
011086   C57BL/6-Tg(Cck-cre)CKres/J
008766   C57BL/6-Tg(Cd8a-cre)1Itan/J
026828   C57BL/6-Tg(Cpa3-cre)4Glli/J
006474   C57BL/6-Tg(Grik4-cre)G32-4Stl/J
008314   C57BL/6-Tg(HBB-cre)12Kpe/J
008870   C57BL/6-Tg(Hspa2-cre)1Eddy/J
016261   C57BL/6-Tg(Nes-cre/ERT2)KEisc/J
012906   C57BL/6-Tg(Nes-cre/Esr1*)1Kuan/J
027205   C57BL/6-Tg(Nms-icre)20Ywa/J
016617   C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog/J
020287   C57BL/6-Tg(Pbsn-cre/Esr1*)14Abch/J
013148   C57BL/6-Tg(Pdgfra-cre)1Clc/J
008535   C57BL/6-Tg(Pf4-cre)Q3Rsko/J
024034   C57BL/6-Tg(Pmch-cre)1Rck/J
016583   C57BL/6-Tg(Slc6a3-icre/ERT2)2Gloss/J
006888   C57BL/6-Tg(Zp3-cre)1Gwh/J
003651   C57BL/6-Tg(Zp3-cre)93Knw/J
021119   C57BL/6J-Tg(Dlx2-cre,-mCherry)4Grsr/GrsrJ
021423   C57BL/6J-Tg(Dlx2-cre,-mCherry)9Grsr/GrsrJ
007567   C57BL/6J-Tg(Itgax-cre,-EGFP)4097Ach/J
018895   C57BL/6J-Tg(Krt6,-cre,-Cerulean)1Grsr/Grsr
018896   C57BL/6J-Tg(Krt6,-cre,-Cerulean)2Grsr/Grsr
018898   C57BL/6J-Tg(Krt6,-cre,-Cerulean)4Grsr/Grsr
018899   C57BL/6J-Tg(Krt6,-cre,-Cerulean)5Grsr/Grsr
021582   C57BL/6J-Tg(Mchr1-cre)1Emf/J
008661   C57BL/6J-Tg(Nkx2-1-cre)2Sand/J
022883   C57BL/6J-Tg(Six6-cre)3Grsr/GrsrJ
022887   C57BL/6J-Tg(Six6-cre)7Grsr/GrsrJ
018754   C57BL/6J-Tg(Tbx22,-cre,-mCherry)1Grsr/GrsrJ
019363   C57BL/6J-Tg(Trp63,-cre,-Cerulean)10Grsr/Grsr
018792   C57BL/6J-Tg(Trp63,-cre,-Cerulean)4Grsr/GrsrJ
003650   C57BL/6J-Tg(Zp3-cre)82Knw/KnwJ
018151   C57BL/6N-Krt17tm1(cre,Cerulean)Murr/GrsrJ
023014   C57BL/6N-Tg(Calcrl,cre)4688Nkza/J
012686   C57BL/6N-Tg(Ppp1r2-cre)4127Nkza/J
016582   C57BL/6N-Tg(Slc32a1-icre/ERT2)3Gloss/J
026861   D2.129P2(B6)-Lyz2tm1(cre)Ifo/SjJ
026858   D2.129S4(B6)-Meox2tm1(cre)Sor/SjJ
026266   D2.B6-Tg(Zp3-cre)93Knw/SjJ
026852   D2.Cg-Tg(Gfap-cre)73.12Mvs/SjJ
024701   D2.Cg-Tg(Plp1-cre/ERT)3Pop/SjJ
026859   D2.Cg-Tg(Sox2-cre)1Amc/SjJ
026857   D2.FVB-Tg(GFAP-cre)25Mes/SjJ
026860   D2.FVB-Tg(Tek-cre)2352Rwng/SjJ
016833   FVB(Cg)-Tg(Alb1-cre)1Dlr/J
012929   FVB(Cg)-Tg(Dhh-cre)1Mejr/J
011034   FVB(Cg)-Tg(Ghrhr-cre)3242Lsk/J
006405   FVB-Tg(Ckmm-cre)5Khn/J
021024   FVB-Tg(Csf1r-icre)1Jwp/J
006954   FVB-Tg(Ddx4-cre)1Dcas/J
004600   FVB-Tg(GFAP-cre)25Mes/J
011037   FVB-Tg(Myh6-cre)2182Mds/J
006364   FVB-Tg(Nr5a1-cre)2Lowl/J
008537   FVB-Tg(Tek-cre)2352Rwng/J
019382   FVB.Cg-Myh9tm1.1Gac Tg(NPHS2-cre)295Lbh/Mmjax
014140   FVB.Cg-Myod1tm2.1(icre)Glh/J
006139   FVB.Cg-Tg(ACTA1-cre)79Jme/J
006297   FVB.Cg-Tg(Eno2-cre)39Jme/J
018394   FVB.Cg-Tg(KRT5-cre/ERT2)2Ipc/JeldJ
008244   FVB.Cg-Tg(tetO-cre)1Jaw/J
003376   FVB/N-Tg(ACTB-cre)2Mrt/J
024384   FVB/N-Tg(AMELX-cre)A1Kul/J
003314   FVB/N-Tg(EIIa-cre)C5379Lmgd/J
025062   FVB/N-Tg(Figla-EGFP,-icre)ZP3Dean/Mmjax
017928   FVB/N-Tg(Mpz-cre)26Mes/J
025066   FVB/N-Tg(Mylpf-cre)3Kraj/Mmjax
006143   FVB/N-Tg(Thy1-cre)1Vln/J
003377   FVB/N-Tg(Zp3-cre)3Mrt/J
023325   FVB;B6-Tg(Pbsn-cre)20Fwan/J
019096   NOD.129P2(B6)-Lyz2tm1(cre)Ifo/NadlJ
023806   NOD.129P2(Cg)-Cd19tm1(cre)Cgn/J
013233   NOD.B6-Tg(Itgax-cre,-EGFP)4097Ach/J
013234   NOD.Cg-Tg(Cd4-cre)1Cwi/2AchJ
023972   NOD.Cg-Tg(Ins2-cre/ERT)1Dam/SbwJ
023203   NOD.Cg-Tg(Itgax-cre)1-1Reiz/PesaJ
005732   NOD.Cg-Tg(Lck-cre)548Jxm/AchJ
023973   NOD.Cg-Tg(Neurog3-cre)1Dam/SbwJ
013251   NOD.FVB-Tg(EIIa-cre)C5379Lmgd/J
008694   NOD/ShiLt-Tg(Foxp3-EGFP/cre)1cJbs/J
004986   NOD/ShiLt-Tg(Ins2-cre)3Lt/LtJ
003855   NOD/ShiLt-Tg(Ins2-cre)5Lt/LtJ
004987   NOD/ShiLt-Tg(Ins2-cre)6Lt/LtJ
012899   STOCK Agrptm1(cre)Lowl/J
026229   STOCK Akap12tm1Ihg Rb1tm2Brn Tg(Pbsn-cre)4Prb/J
012706   STOCK Ccktm1.1(cre)Zjh/J
010910   STOCK Corttm1(cre)Zjh/J
007916   STOCK En1tm2(cre)Wrst/J
008464   STOCK Foxa2tm2.1(cre/Esr1*)Moon/J
010802   STOCK Gad2tm2(cre)Zjh/J
018903   STOCK Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
023407   STOCK HhatTg(TFAP2A-cre)1Will/J
008876   STOCK Hprttm11(Ple176-EGFP/cre)Ems/Mmjax
016879   STOCK Il17atm1.1(icre)Stck/J
024242   STOCK Isl1tm1(cre)Sev/J
018976   STOCK Kdrtm1(cre)Sato/J
017701   STOCK Kiss1tm1.1(cre/EGFP)Stei/J
007022   STOCK Mnx1tm4(cre)Tmj Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
004192   STOCK Mttptm2Sgy Ldlrtm1Her Apobtm2Sgy Tg(Mx1-cre)1Cgn/J
023342   STOCK Myf5tm1(cre/Esr1*)Trdo/J
024713   STOCK Myl1tm1(cre)Sjb/J
014180   STOCK Myocdtm1(cre)Jomm/J
006953   STOCK Notch1tm3(cre)Rko/J
006677   STOCK Olfr151tm28(cre)Mom/MomJ
011103   STOCK Olig2tm2(TVA,cre)Rth/J
010530   STOCK Pax7tm1(cre)Mrc/J
016963   STOCK Slc17a6tm2(cre)Lowl/J
016962   STOCK Slc32a1tm2(cre)Lowl/J
013044   STOCK Ssttm2.1(cre)Zjh/J
012719   STOCK Tgfb3tm1(cre)Vk/J
012620   STOCK Trp53tm1Brd Brca1tm1Aash Tg(LGB-cre)74Acl/J
010908   STOCK Viptm1(cre)Zjh/J
010911   STOCK Wt1tm1(EGFP/cre)Wtp/J
009615   STOCK Tg(Cartpt-cre)1Aibs/J
017336   STOCK Tg(Cd4-cre)1Cwi/BfluJ
005105   STOCK Tg(Chx10-EGFP/cre,-ALPP)2Clc/J
008852   STOCK Tg(En2-cre)22Alj/J
005938   STOCK Tg(Eno2-cre)39Jme/J
011062   STOCK Tg(Gdf9-cre)5092Coo/J
012841   STOCK Tg(Ggt1-cre)M3Egn/J
021207   STOCK Tg(Gnrh1-cre)1Dlc/J
017981   STOCK Tg(Hoxb6-cre)#Mku/J
004692   STOCK Tg(Hoxb7-cre)13Amc/J
014600   STOCK Tg(I12b-cre/ERT2,-ALPP)37Fsh/J
008122   STOCK Tg(Ins2-cre/ERT)1Dam/J
004782   STOCK Tg(KRT14-cre)1Amc/J
005107   STOCK Tg(KRT14-cre/ERT)20Efu/J
008582   STOCK Tg(Kcnc2-Cre)K128Stl/LetJ
023426   STOCK Tg(Kiss1-cre)J2-4Cfe/J
017836   STOCK Tg(LGB-cre)74Acl/J
003551   STOCK Tg(MMTV-cre)1Mam/J
003553   STOCK Tg(MMTV-cre)4Mam/J
002527   STOCK Tg(Mx1-cre)1Cgn/J
009074   STOCK Tg(Myh6-cre)1Jmk/J
005650   STOCK Tg(Myh6-cre/Esr1*)1Jmk/J
009102   STOCK Tg(Nefh-cre)12Kul/J
002858   STOCK Tg(Nes-cre)1Wme/J
002859   STOCK Tg(Nes-cre)2Wme/J
012859   STOCK Tg(Neurog1-cre)1Jejo/J
005667   STOCK Tg(Neurog3-cre)C1Able/J
008119   STOCK Tg(Neurog3-cre/Esr1*)1Dam/J
012462   STOCK Tg(Nr5a1-cre)7Lowl/J
014158   STOCK Tg(Pax4-cre)1Dam/J
024578   STOCK Tg(Pax6-GFP/cre)1Rilm/J
006207   STOCK Tg(Pcp2-cre)1Amc/J
014099   STOCK Tg(Pmch-cre)1Lowl/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
012452   STOCK Tg(Rr5-GFP/cre)1Sapc/J
006395   STOCK Tg(Sim1-cre)1Lowl/J
009606   STOCK Tg(Six2-EGFP/cre)1Amc/J
019755   STOCK Tg(Six3-cre)69Frty/GcoJ
018147   STOCK Tg(Slc17a8-icre)1Edw/SealJ
012586   STOCK Tg(Slc1a3-cre/ERT)1Nat/J
004783   STOCK Tg(Sox2-cre)1Amc/J
008208   STOCK Tg(Stra8-icre)1Reb/J
016236   STOCK Tg(TCF/Lef1-cre/ERT2)1Dje/J
004746   STOCK Tg(Tagln-cre)1Her/J
012708   STOCK Tg(Thy1-cre/ERT2,-EYFP)HGfng/PyngJ
024240   STOCK Tg(Tnnt2-cre)5Blh/JiaoJ
016584   STOCK Tg(Tph2-icre/ERT2)6Gloss/J
003829   STOCK Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
008851   STOCK Tg(Wnt1-cre/ERT)1Alj/J
018281   STOCK Tg(Wnt7a-EGFP/cre)#Bhr/Mmjax
008199   STOCK Tg(dlx6a-cre)1Mekk/J
002471   STOCK Tg(hCMV-cre)140Sau/J
023724   STOCK Tg(mI56i-cre,EGFP)1Kc/J
006224   STOCK Tg(tetO-cre)1Jaw/J
View Strains carrying other alleles of cre     (401 strains)

Additional Web Information

Introduction to Cre-lox technology


Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.


        involves: 129S2/SvPas * C57BL/6
  • normal phenotype
  • no abnormal phenotype detected
    • homozygous mice do not show any of the abnormal phenotypes shown for Emx1tm1Jlr homozygotes   (MGI Ref ID J:78098)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Neurobiology Research
Cre-lox System
      Cre Recombinase expression in neural tissue
Neurodevelopmental Defects

Research Tools
Cre-lox System
      Cre Recombinase Expression
      Cre Recombinase Expression: Germline/Embryonic Expression
Developmental Biology Research
      Cre-lox System
Neurobiology Research

cre related

Research Tools
Cre-lox System
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Cre-lox System

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Emx1tm1(cre)Krj
Allele Name targeted mutation 1, Kevin R Jones
Allele Type Targeted (cre- or Flp-expressing)
Common Name(s) Emx1-IRES-Cre; Emx1IREScre; emx1-cre;
Mutation Made By Kevin Jones,   University of Colorado- Boulder
Strain of Origin129S2/SvPas
ES Cell Line NameD3
ES Cell Line Strain129S2/SvPas
Site of Expressionneurons of the neocortex and hippocampus; some germline
Expressed Gene cre, cre recombinase, bacteriophage P1
Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence.
Driver Note Emx1
Molecular Note An IRES-cre gene followed by an FRT flanked PGK-neomycin gene was inserted 120 bp 3' of the stop codon. The neomycin gene was later removed in vivo by crossing to an Flp recombinase expressing transgenic strain. The protein product of this gene was produced in normal quantities as confirmed by Western blot analysis. Cre recombinase expression was characterized by crossing to a Rosa26 strain. [MGI Ref ID J:78098]
Gene Symbol and Name Emx1, empty spiracles homeobox 1
Chromosome 6
Gene Common Name(s) RGD1564002;


Genotyping Information

Genotyping Protocols

Emx1tm1(cre)Krj, MELT
Emx1tm1(cre)Krj, Standard PCR
Generic Cre Melt Curve Analysis, MELT
Generic Cre Melt Curve Analysis, Probe
Generic Cre, Standard PCR

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Gorski JA; Talley T; Qiu M; Puelles L; Rubenstein JL; Jones KR. 2002. Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage. J Neurosci 22(15):6309-14. [PubMed: 12151506]  [MGI Ref ID J:78098]

Additional References

Emx1tm1(cre)Krj related

Ahmari SE; Spellman T; Douglass NL; Kheirbek MA; Simpson HB; Deisseroth K; Gordon JA; Hen R. 2013. Repeated cortico-striatal stimulation generates persistent OCD-like behavior. Science 340(6137):1234-9. [PubMed: 23744948]  [MGI Ref ID J:199177]

Alfano C; Viola L; Heng JI; Pirozzi M; Clarkson M; Flore G; De Maio A; Schedl A; Guillemot F; Studer M. 2011. COUP-TFI promotes radial migration and proper morphology of callosal projection neurons by repressing Rnd2 expression. Development 138(21):4685-97. [PubMed: 21965613]  [MGI Ref ID J:178862]

Amaniti EM; Hasenpusch-Theil K; Li Z; Magnani D; Kessaris N; Mason JO; Theil T. 2013. Gli3 is required in Emx1(+) progenitors for the development of the corpus callosum. Dev Biol 376(2):113-24. [PubMed: 23396189]  [MGI Ref ID J:195145]

Antoine MW; Hubner CA; Arezzo JC; Hebert JM. 2013. A causative link between inner ear defects and long-term striatal dysfunction. Science 341(6150):1120-3. [PubMed: 24009395]  [MGI Ref ID J:201156]

Armentano M; Chou SJ; Tomassy GS; Leingartner A; O'Leary DD; Studer M. 2007. COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas. Nat Neurosci 10(10):1277-86. [PubMed: 17828260]  [MGI Ref ID J:127387]

Armour EA; Carson RP; Ess KC. 2012. Cystogenesis and elongated primary cilia in Tsc1-deficient distal convoluted tubules. Am J Physiol Renal Physiol 303(4):F584-92. [PubMed: 22674026]  [MGI Ref ID J:188431]

Ballester-Rosado CJ; Albright MJ; Wu CS; Liao CC; Zhu J; Xu J; Lee LJ; Lu HC. 2010. mGluR5 in cortical excitatory neurons exerts both cell-autonomous and -nonautonomous influences on cortical somatosensory circuit formation. J Neurosci 30(50):16896-909. [PubMed: 21159961]  [MGI Ref ID J:167595]

Baquet ZC; Gorski JA; Jones KR. 2004. Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor. J Neurosci 24(17):4250-8. [PubMed: 15115821]  [MGI Ref ID J:96903]

Bareyre FM; Kerschensteiner M; Misgeld T; Sanes JR. 2005. Transgenic labeling of the corticospinal tract for monitoring axonal responses to spinal cord injury. Nat Med 11(12):1355-60. [PubMed: 16286922]  [MGI Ref ID J:123607]

Barnes AP; Lilley BN; Pan YA; Plummer LJ; Powell AW; Raines AN; Sanes JR; Polleux F. 2007. LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons. Cell 129(3):549-63. [PubMed: 17482548]  [MGI Ref ID J:162066]

Barros CS; Calabrese B; Chamero P; Roberts AJ; Korzus E; Lloyd K; Stowers L; Mayford M; Halpain S; Muller U. 2009. Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system. Proc Natl Acad Sci U S A 106(11):4507-12. [PubMed: 19240213]  [MGI Ref ID J:146779]

Beggs HE; Schahin-Reed D; Zang K; Goebbels S; Nave KA; Gorski J; Jones KR; Sretavan D; Reichardt LF. 2003. FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular dystrophies. Neuron 40(3):501-14. [PubMed: 14642275]  [MGI Ref ID J:86453]

Benadiba C; Magnani D; Niquille M; Morle L; Valloton D; Nawabi H; Ait-Lounis A; Otsmane B; Reith W; Theil T; Hornung JP; Lebrand C; Durand B. 2012. The ciliogenic transcription factor RFX3 regulates early midline distribution of guidepost neurons required for corpus callosum development. PLoS Genet 8(3):e1002606. [PubMed: 22479201]  [MGI Ref ID J:183848]

Berger J; Berger S; Tuoc TC; D'Amelio M; Cecconi F; Gorski JA; Jones KR; Gruss P; Stoykova A. 2007. Conditional activation of Pax6 in the developing cortex of transgenic mice causes progenitor apoptosis. Development 134(7):1311-22. [PubMed: 17329367]  [MGI Ref ID J:135032]

Betley JN; Wright CV; Kawaguchi Y; Erdelyi F; Szabo G; Jessell TM; Kaltschmidt JA. 2009. Stringent specificity in the construction of a GABAergic presynaptic inhibitory circuit. Cell 139(1):161-74. [PubMed: 19804761]  [MGI Ref ID J:157313]

Bloodgood BL; Sharma N; Browne HA; Trepman AZ; Greenberg ME. 2013. The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition. Nature 503(7474):121-5. [PubMed: 24201284]  [MGI Ref ID J:207770]

Bloom AJ; Miller BR; Sanes JR; Diantonio A. 2007. The requirement for Phr1 in CNS axon tract formation reveals the corticostriatal boundary as a choice point for cortical axons. Genes Dev 21(20):2593-606. [PubMed: 17901218]  [MGI Ref ID J:125702]

Boretius S; Michaelis T; Tammer R; Ashery-Padan R; Frahm J; Stoykova A. 2009. In vivo MRI of altered brain anatomy and fiber connectivity in adult pax6 deficient mice. Cereb Cortex 19(12):2838-47. [PubMed: 19329571]  [MGI Ref ID J:174170]

Borgius L; Nishimaru H; Caldeira V; Kunugise Y; Low P; Reig R; Itohara S; Iwasato T; Kiehn O. 2014. Spinal glutamatergic neurons defined by EphA4 signaling are essential components of normal locomotor circuits. J Neurosci 34(11):3841-53. [PubMed: 24623763]  [MGI Ref ID J:209606]

Brinkmann BG; Agarwal A; Sereda MW; Garratt AN; Muller T; Wende H; Stassart RM; Nawaz S; Humml C; Velanac V; Radyushkin K; Goebbels S; Fischer TM; Franklin RJ; Lai C; Ehrenreich H; Birchmeier C; Schwab MH; Nave KA. 2008. Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system. Neuron 59(4):581-95. [PubMed: 18760695]  [MGI Ref ID J:145464]

Brown KN; Chen S; Han Z; Lu CH; Tan X; Zhang XJ; Ding L; Lopez-Cruz A; Saur D; Anderson SA; Huang K; Shi SH. 2011. Clonal production and organization of inhibitory interneurons in the neocortex. Science 334(6055):480-6. [PubMed: 22034427]  [MGI Ref ID J:177854]

Caronia G; Wilcoxon J; Feldman P; Grove EA. 2010. Bone morphogenetic protein signaling in the developing telencephalon controls formation of the hippocampal dentate gyrus and modifies fear-related behavior. J Neurosci 30(18):6291-301. [PubMed: 20445055]  [MGI Ref ID J:160559]

Caronia-Brown G; Grove EA. 2011. Timing of cortical interneuron migration is influenced by the cortical hem. Cereb Cortex 21(4):748-55. [PubMed: 20713502]  [MGI Ref ID J:181828]

Carson RP; Fu C; Winzenburger P; Ess KC. 2013. Deletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex. Hum Mol Genet 22(1):140-52. [PubMed: 23049074]  [MGI Ref ID J:191137]

Carson RP; Van Nielen DL; Winzenburger PA; Ess KC. 2012. Neuronal and glia abnormalities in Tsc1-deficient forebrain and partial rescue by rapamycin. Neurobiol Dis 45(1):369-80. [PubMed: 21907282]  [MGI Ref ID J:179842]

Cederquist GY; Azim E; Shnider SJ; Padmanabhan H; Macklis JD. 2013. Lmo4 establishes rostral motor cortex projection neuron subtype diversity. J Neurosci 33(15):6321-32. [PubMed: 23575831]  [MGI Ref ID J:196674]

Chou SJ; Perez-Garcia CG; Kroll TT; O'Leary DD. 2009. Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex. Nat Neurosci 12(11):1381-9. [PubMed: 19820705]  [MGI Ref ID J:154611]

Cocas LA; Miyoshi G; Carney RS; Sousa VH; Hirata T; Jones KR; Fishell G; Huntsman MM; Corbin JG. 2009. Emx1-lineage progenitors differentially contribute to neural diversity in the striatum and amygdala. J Neurosci 29(50):15933-46. [PubMed: 20016109]  [MGI Ref ID J:157097]

D'Acunzo P; Badaloni A; Ferro M; Ripamonti M; Zimarino V; Malgaroli A; Consalez GG. 2014. A conditional transgenic reporter of presynaptic terminals reveals novel features of the mouse corticospinal tract. Front Neuroanat 7:50. [PubMed: 24431991]  [MGI Ref ID J:206865]

De Marco Garcia NV; Priya R; Tuncdemir SN; Fishell G; Karayannis T. 2015. Sensory inputs control the integration of neurogliaform interneurons into cortical circuits. Nat Neurosci 18(3):393-401. [PubMed: 25664912]  [MGI Ref ID J:221909]

Depaepe V; Suarez-Gonzalez N; Dufour A; Passante L; Gorski JA; Jones KR; Ledent C; Vanderhaeghen P. 2005. Ephrin signalling controls brain size by regulating apoptosis of neural progenitors. Nature 435(7046):1244-50. [PubMed: 15902206]  [MGI Ref ID J:99355]

Ding Y; Qu Y; Feng J; Wang M; Han Q; So KF; Wu W; Zhou L. 2014. Functional motor recovery from motoneuron axotomy is compromised in mice with defective corticospinal projections. PLoS One 9(7):e101918. [PubMed: 25003601]  [MGI Ref ID J:218923]

Dissing-Olesen L; LeDue JM; Rungta RL; Hefendehl JK; Choi HB; MacVicar BA. 2014. Activation of neuronal NMDA receptors triggers transient ATP-mediated microglial process outgrowth. J Neurosci 34(32):10511-27. [PubMed: 25100586]  [MGI Ref ID J:215582]

Elia LP; Yamamoto M; Zang K; Reichardt LF. 2006. p120 catenin regulates dendritic spine and synapse development through Rho-family GTPases and cadherins. Neuron 51(1):43-56. [PubMed: 16815331]  [MGI Ref ID J:110469]

English CN; Vigers AJ; Jones KR. 2012. Genetic evidence that brain-derived neurotrophic factor mediates competitive interactions between individual cortical neurons. Proc Natl Acad Sci U S A 109(47):19456-61. [PubMed: 23129644]  [MGI Ref ID J:192261]

Fu C; Ess KC. 2013. Conditional and domain-specific inactivation of the Tsc2 gene in neural progenitor cells. Genesis 51(4):284-92. [PubMed: 23359422]  [MGI Ref ID J:195049]

Fuentes F; Zimmer D; Atienza M; Schottenfeld J; Penkala I; Bale T; Bence KK; Arregui CO. 2012. Protein tyrosine phosphatase PTP1B is involved in hippocampal synapse formation and learning. PLoS One 7(7):e41536. [PubMed: 22844492]  [MGI Ref ID J:189720]

Garrett AM; Schreiner D; Lobas MA; Weiner JA. 2012. gamma-protocadherins control cortical dendrite arborization by regulating the activity of a FAK/PKC/MARCKS signaling pathway. Neuron 74(2):269-76. [PubMed: 22542181]  [MGI Ref ID J:188387]

Gee JM; Smith NA; Fernandez FR; Economo MN; Brunert D; Rothermel M; Morris SC; Talbot A; Palumbos S; Ichida JM; Shepherd JD; West PJ; Wachowiak M; Capecchi MR; Wilcox KS; White JA; Tvrdik P. 2014. Imaging Activity in Neurons and Glia with a Polr2a-Based and Cre-Dependent GCaMP5G-IRES-tdTomato Reporter Mouse. Neuron :. [PubMed: 25155958]  [MGI Ref ID J:212315]

Genetic Resource Science at The Jackson Laboratory. 2008. Expression/Specificity Patterns of Cre Alleles Direct Data Submission from Genetic Resource Science :.  [MGI Ref ID J:137887]

Genetic Resource Science at The Jackson Laboratory. 2012. Expression/Specificity Patterns of Cre Alleles, 2011 Direct Data Submission from Genetic Resource Science :.  [MGI Ref ID J:184578]

Gil-Sanz C; Landeira B; Ramos C; Costa MR; Muller U. 2014. Proliferative defects and formation of a double cortex in mice lacking Mltt4 and Cdh2 in the dorsal telencephalon. J Neurosci 34(32):10475-87. [PubMed: 25100583]  [MGI Ref ID J:215584]

Goffin D; Brodkin ES; Blendy JA; Siegel SJ; Zhou Z. 2014. Cellular origins of auditory event-related potential deficits in Rett syndrome. Nat Neurosci 17(6):804-6. [PubMed: 24777420]  [MGI Ref ID J:212933]

Gorski JA; Balogh SA; Wehner JM; Jones KR. 2003. Learning deficits in forebrain-restricted brain-derived neurotrophic factor mutant mice. Neuroscience 121(2):341-54. [PubMed: 14521993]  [MGI Ref ID J:100000]

Gorski JA; Zeiler SR; Tamowski S; Jones KR. 2003. Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites. J Neurosci 23(17):6856-65. [PubMed: 12890780]  [MGI Ref ID J:84683]

Griveau A; Borello U; Causeret F; Tissir F; Boggetto N; Karaz S; Pierani A. 2010. A novel role for Dbx1-derived Cajal-Retzius cells in early regionalization of the cerebral cortical neuroepithelium. PLoS Biol 8(7):e1000440. [PubMed: 20668538]  [MGI Ref ID J:165303]

Hantman AW; Jessell TM. 2010. Clarke's column neurons as the focus of a corticospinal corollary circuit. Nat Neurosci 13(10):1233-9. [PubMed: 20835249]  [MGI Ref ID J:211843]

Harris JA; Hirokawa KE; Sorensen SA; Gu H; Mills M; Ng LL; Bohn P; Mortrud M; Ouellette B; Kidney J; Smith KA; Dang C; Sunkin S; Bernard A; Oh SW; Madisen L; Zeng H. 2014. Anatomical characterization of Cre driver mice for neural circuit mapping and manipulation. Front Neural Circuits 8:76. [PubMed: 25071457]  [MGI Ref ID J:220523]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX10

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, these mice are bred as homozygotes.
Mating SystemHomozygote x Homozygote         (Female x Male)   02-NOV-06
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $239.00Female or MaleHomozygous for Emx1tm1(cre)Krj  
Price per Pair (US dollars $)Pair Genotype
$478.00Homozygous for Emx1tm1(cre)Krj x Homozygous for Emx1tm1(cre)Krj  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $310.70Female or MaleHomozygous for Emx1tm1(cre)Krj  
Price per Pair (US dollars $)Pair Genotype
$621.40Homozygous for Emx1tm1(cre)Krj x Homozygous for Emx1tm1(cre)Krj  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

   000664 C57BL/6J
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice
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Tel: 1-800-422-6423 or 1-207-288-5845
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Terms of Use

Terms of Use

General Terms and Conditions

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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.