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- Description
- Phenotype
- Genes & alleles
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Description
Strain Information
Former Names B6.SJL-Tg(ACTFLPe)9205Dym/J (Changed: 11-JUL-07 ) Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered Mutant Mice. Mating System +/+ sibling x Hemizygote (Female x Male) Species laboratory mouse Generation N10 (08-OCT-08) Donating Investigator IMR Colony, The Jackson Laboratory Description
This transgenic strain expresses a variant of the Saccharomyces cerevisiae FLP1 recombinase gene under the direction of the human ACTB promoter. The FLPe recombinase variant exhibits enhanced thermostability with recombination activity being four-fold and ten-fold that of wildtype FLP at 37oC and 40oC, respectively. Mice that are hemizygous for the transgenic allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Recombinase activity is detected in a wide variety of tissues (spinal cord, heart, gonad, adrenal) as early as embryonic day 10.5. This deleter strain is a suitable alternative to, and complement with the Cre-loxP system for in vivo genetic engineering.In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
Development
A transgenic construct containing a FLP1 recombinase variant controlled by the human ACTB promoter (3 kb flanking sequence, 78-bp 5' untranslated region, 832-bp of exon 1) was injected into fertilized eggs from B6SJLF2 mice. Founder animals were obtained and crossed with C57BL/6J mice.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Tg(ACTFLPe)9205Dym allele
003800 B6;SJL-Tg(ACTFLPe)9205Dym/J View Strains carrying Tg(ACTFLPe)9205Dym (1 strain)
005145 C57BL/6-Tg(CAG-OVA)916Jen/J 005863 C57BL/6J-Tg(ACTB-DDAH1)1Jpck/J 002981 DBA/2-Tg(xstpx-lacZ)36And/J 003376 FVB/N-Tg(ACTB-cre)2Mrt/J 008200 FVB/N-Tg(CAG-EGFP,-ALPP)2.6Ggc/J 005438 STOCK Tg(CAG-Bgeo,-DsRed*MST)1Nagy/J
Additional Web Information
Congenic Nomenclature
FLP-FRT Systems
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
FLP1 relatedResearch Tools
FLP-FRT System (FLP Recombinase Expression: Germline/Embryonic Expression)
Genetics Research (Mutagenesis and Transgenesis: FLP recombinase)
Research Tools
Genetics Research (Mutagenesis and Transgenesis: FLP recombinase)
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tg(ACTFLPe)9205Dym | ||
|---|---|---|---|
| Allele Name | transgene insertion 9205, Susan Dymecki | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | ACT-FLPe; ACTB:FLPe; CAGG-Flpr; FLPe; Flp; Flp deleter; TgpCAG-flpe; actin-FLPe; beta-actinFLPe; hACTB-FLPe; hACTB::FLPe; | ||
| Mutation Made By | Susan Dymecki, Harvard Medical School | ||
| Strain of Origin | (C57BL/6 x SJL)F2 | ||
| Site of Expression | expression of the enhanced FLP1 recombinase variant (FLPe) is detected in a wide variety of tissues (spinal cord, heart, gonad, adrenal) as early as embryonic day 10.5 | ||
| Expressed Gene | FLP1, FLP1 recombinase, Saccharomyces cerevisiae | ||
| FLP1 recombinase is an enzyme derived from Saccharomyces cerevisiae that specifically recognizes a 34 base pair FLP1 recombinase target (FRT) sequence. FLP1 has been shown to effectively mediate the excision of DNA located between similarly oriented FRT sites. After the excision event, DNA ends recombine leaving a single FRT site in place of the intervening sequence. DNA located between oppositely orientated FRT sites is inverted rather than deleted. | |||
| Promoter | ACTB, actin, beta, human | ||
| General Note | The FLPe recombinase variant exhibits enhanced thermostability with recombination activity being 4X and 10X that of wildtype FLP at 37°C and 40°C, respectively. Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. | ||
| Molecular Note | Sequence encoding FLP1 was adjoined to human ACTB promoter sequence, including 3 kb of promoter sequence and an 0.8 kb portion of exon 1. The promoter region drives expression in the germline. Recombinase activity is detected in a wide variety of tissues (spinal cord, heart, gonad, adrenal) as early as embryonic day 10.5. [MGI Ref ID J:137185] [MGI Ref ID J:78660] [MGI Ref ID J:79431] [MGI Ref ID J:92210] [MGI Ref ID J:98828] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Tg(ACTFLPe)9205Dym, STD PCR, vers. 1
Helpful Links
Optimizing PCR Protocols
References
References
Selected Reference(s)
Rodriguez CI; Buchholz F; Galloway J; Sequerra R; Kasper J; Ayala R; Stewart AF; Dymecki SM. 2000. High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP. Nat Genet 25(2):139-40. [PubMed: 10835623] [MGI Ref ID J:78660]
Additional References
Tg(ACTFLPe)9205Dym relatedAdams JW; Wang J; Davis JR; Liaw C; Gaidarov I; Gatlin J; Dalton ND; Gu Y; Ross J Jr; Behan D; Chien K; Connolly D. 2008. Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor. Am J Physiol Heart Circ Physiol 295(2):H509-21. [PubMed: 18539757] [MGI Ref ID J:138227]
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Kim Y; Phan D; van Rooij E; Wang DZ; McAnally J; Qi X; Richardson JA; Hill JA; Bassel-Duby R; Olson EN. 2008. The MEF2D transcription factor mediates stress-dependent cardiac remodeling in mice. J Clin Invest 118(1):124-32. [PubMed: 18079970] [MGI Ref ID J:130825]
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Klose RJ; Yan Q; Tothova Z; Yamane K; Erdjument-Bromage H; Tempst P; Gilliland DG; Zhang Y; Kaelin WG Jr. 2007. The retinoblastoma binding protein RBP2 is an H3K4 demethylase. Cell 128(5):889-900. [PubMed: 17320163] [MGI Ref ID J:137185]
Kostetskii I; Li J; Xiong Y; Zhou R; Ferrari VA; Patel VV; Molkentin JD; Radice GL. 2005. Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure. Circ Res 96(3):346-54. [PubMed: 15662031] [MGI Ref ID J:98828]
Kramer ER; Knott L; Su F; Dessaud E; Krull CE; Helmbacher F; Klein R. 2006. Cooperation between GDNF/Ret and ephrinA/EphA4 signals for motor-axon pathway selection in the limb. Neuron 50(1):35-47. [PubMed: 16600854] [MGI Ref ID J:110955]
Kreuzberg MM; Schrickel JW; Ghanem A; Kim JS; Degen J; Janssen-Bienhold U; Lewalter T; Tiemann K; Willecke K. 2006. Connexin30.2 containing gap junction channels decelerate impulse propagation through the atrioventricular node. Proc Natl Acad Sci U S A 103(15):5959-64. [PubMed: 16571663] [MGI Ref ID J:108288]
Kwon K; Hutter C; Sun Q; Bilic I; Cobaleda C; Malin S; Busslinger M. 2008. Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development. Immunity 28(6):751-62. [PubMed: 18538592] [MGI Ref ID J:137719]
Lapinski PE; Bauler TJ; Brown EJ; Hughes ED; Saunders TL; King PD. 2007. Generation of mice with a conditional allele of the p120 Ras GTPase-activating protein. Genesis 45(12):762-7. [PubMed: 18064675] [MGI Ref ID J:130493]
Lapinski PE; Oliver JA; Kamen LA; Hughes ED; Saunders TL; King PD. 2008. Genetic analysis of SH2D4A, a novel adapter protein related to T cell-specific adapter and adapter protein in lymphocytes of unknown function, reveals a redundant function in T cells. J Immunol 181(3):2019-27. [PubMed: 18641339] [MGI Ref ID J:139245]
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Liang X; Zhou Q; Li X; Sun Y; Lu M; Dalton N; Ross J Jr; Chen J. 2005. PINCH1 plays an essential role in early murine embryonic development but is dispensable in ventricular cardiomyocytes. Mol Cell Biol 25(8):3056-62. [PubMed: 15798193] [MGI Ref ID J:97635]
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Saburi S; Hester I; Fischer E; Pontoglio M; Eremina V; Gessler M; Quaggin SE; Harrison R; Mount R; McNeill H. 2008. Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease. Nat Genet 40(8):1010-5. [PubMed: 18604206] [MGI Ref ID J:138247]
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Sato T; Mushiake S; Kato Y; Sato K; Sato M; Takeda N; Ozono K; Miki K; Kubo Y; Tsuji A; Harada R; Harada A. 2007. The Rab8 GTPase regulates apical protein localization in intestinal cells. Nature 448(7151):366-9. [PubMed: 17597763] [MGI Ref ID J:123415]
Schmidt-Supprian M; Wunderlich FT; Rajewsky K. 2007. Excision of the Frt-flanked neo ( R ) cassette from the CD19cre knock-in transgene reduces Cre-mediated recombination. Transgenic Res 16(5):657-60. [PubMed: 17541717] [MGI Ref ID J:125035]
Schnichels M; Worsdorfer P; Dobrowolski R; Markopoulos C; Kretz M; Schwarz G; Winterhager E; Willecke K. 2007. The Connexin31 F137L mutant mouse as a model for the human skin disease Erythrokeratodermia variabilis (EKV). Hum Mol Genet 16(10):1216-24. [PubMed: 17446259] [MGI Ref ID J:121802]
Sgaier SK; Lao Z; Villanueva MP; Berenshteyn F; Stephen D; Turnbull RK; Joyner AL. 2007. Genetic subdivision of the tectum and cerebellum into functionally related regions based on differential sensitivity to engrailed proteins. Development 134(12):2325-35. [PubMed: 17537797] [MGI Ref ID J:134516]
Shen J; Walsh CA. 2005. Targeted disruption of tgif, the mouse ortholog of a human holoprosencephaly gene, does not result in holoprosencephaly in mice. Mol Cell Biol 25(9):3639-47. [PubMed: 15831469] [MGI Ref ID J:97642]
Shibazaki S; Yu Z; Nishio S; Tian X; Thomson RB; Mitobe M; Louvi A; Velazquez H; Ishibe S; Cantley LG; Igarashi P; Somlo S. 2008. Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1. Hum Mol Genet 17(11):1505-16. [PubMed: 18263604] [MGI Ref ID J:135301]
Shim K; Minowada G; Coling DE; Martin GR. 2005. Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling. Dev Cell 8(4):553-64. [PubMed: 15809037] [MGI Ref ID J:98303]
Shiota C; Woo JT; Lindner J; Shelton KD; Magnuson MA. 2006. Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev Cell 11(4):583-9. [PubMed: 16962829] [MGI Ref ID J:119564]
Shroyer NF; Helmrath MA; Wang VY; Antalffy B; Henning SJ; Zoghbi HY. 2007. Intestine-specific ablation of mouse atonal homolog 1 (Math1) reveals a role in cellular homeostasis. Gastroenterology 132(7):2478-88. [PubMed: 17570220] [MGI Ref ID J:128312]
Shui JW; Hu MC; Tan TH. 2007. Conditional knockout mice reveal an essential role of protein phosphatase 4 in thymocyte development and pre-T-cell receptor signaling. Mol Cell Biol 27(1):79-91. [PubMed: 17060460] [MGI Ref ID J:117684]
Sklyarova T; Bonne S; D'Hooge P; Denecker G; Goossens S; De Rycke R; Borgonie G; Bosl M; van Roy F; van Hengel J. 2008. Plakophilin-3-deficient mice develop hair coat abnormalities and are prone to cutaneous inflammation. J Invest Dermatol 128(6):1375-85. [PubMed: 18079750] [MGI Ref ID J:136451]
Skvorak K; Vissel B; Homanics GE. 2006. Production of conditional point mutant knockin mice. Genesis 44(7):345-53. [PubMed: 16832820] [MGI Ref ID J:110982]
Sodhi CP; Li J; Duncan SA. 2006. Generation of mice harbouring a conditional loss-of-function allele of Gata6. BMC Dev Biol 6:19. [PubMed: 16611361] [MGI Ref ID J:111388]
Stanley EG; Biben C; Elefanty A; Barnett L; Koentgen F; Robb L; Harvey RP. 2002. Efficient Cre-mediated deletion in cardiac progenitor cells conferred by a 3'UTR-ires-Cre allele of the homeobox gene Nkx2-5. Int J Dev Biol 46(4):431-9. [PubMed: 12141429] [MGI Ref ID J:80725]
Sun L; Wu X; Han M; Xu T; Zhuang Y. 2008. A mitotic recombination system for mouse chromosome 17. Proc Natl Acad Sci U S A 105(11):4237-41. [PubMed: 18326030] [MGI Ref ID J:133177]
Takahashi Y; Yasuhiko Y; Kitajima S; Kanno J; Saga Y. 2007. Appropriate suppression of Notch signaling by Mesp factors is essential for stripe pattern formation leading to segment boundary formation. Dev Biol 304(2):593-603. [PubMed: 17306789] [MGI Ref ID J:122532]
Takamiya K; Mao L; Huganir RL; Linden DJ. 2008. The glutamate receptor-interacting protein family of GluR2-binding proteins is required for long-term synaptic depression expression in cerebellar Purkinje cells. J Neurosci 28(22):5752-5. [PubMed: 18509036] [MGI Ref ID J:136388]
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Uesaka T; Jain S; Yonemura S; Uchiyama Y; Milbrandt J; Enomoto H. 2007. Conditional ablation of GFRalpha1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype. Development 134(11):2171-81. [PubMed: 17507417] [MGI Ref ID J:122607]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry This strain originated on a B6SJLF2 background and has been backcrossed to C57BL/6J for 5 generations. Coat color expected from breeding: Black. Mating System +/+ sibling x Hemizygote (Female x Male) Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $236.40 Female or Male Hemizygous for Tg(ACTFLPe)9205Dym *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $288.65 Hemizygous for Tg(ACTFLPe)9205Dym x Noncarrier $288.65 Noncarrier x Hemizygous for Tg(ACTFLPe)9205Dym
Additional Supply Details
| Supply Notes |
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| Pricing for International shipping destinations |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $307.40 Female or Male Hemizygous for Tg(ACTFLPe)9205Dym *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $375.30 Hemizygous for Tg(ACTFLPe)9205Dym x Noncarrier $375.30 Noncarrier x Hemizygous for Tg(ACTFLPe)9205Dym
Additional Supply Details
| Supply Notes |
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
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| Supply Notes |
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Control Information
| Control | ||
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| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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Terms of Use
Terms of Use
General Terms and Conditions
For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
- Use of MICE by companies or for-profit entities requires a license.
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| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice & Services Conditions of Use
“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. THE LABORATORY EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of MICE, products or services, The Jackson Laboratory will, at its option, provide credit or replacement for the MICE or product received or the services provided.
No Liability
In no event shall The Jackson Laboratory, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, products or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of The Jackson Laboratory, its agents or employees. In purchasing or receiving MICE, products or services from The Jackson Laboratory, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges The Jackson Laboratory from all such causes of action or damages, and further agrees to defend and indemnify The Jackson Laboratory from any costs or damages arising out of any third party claims.
MICE and biological materials are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to The Jackson Laboratory’s MICE, products and services. In addition, special terms and conditions of sale of certain MICE, products and services may be set forth separately in The Jackson Laboratory web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, products and services by The Jackson Laboratory, and by its licensees and distributors.
Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.