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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
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Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Type Mutant Stock; Targeted Mutation; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation ?+F2p Donating Investigator Brenda Coomber, University of Guelph Description
Mice homozygous for both the targeted mutation and the transgene are viable and fertile. The transgene beta-galactosidase is well expressed, reflects endogenous Tek/Tie2 activity, and is specific to the vascular endothelium. Mice homozygous for the Rag1 mutation are immunodeficient as they lack mature B and T lymphocytes. This double mutant mouse may be useful in studies of cancer, tumor-related angiogenesis, and as a recipient of xenografted tumors.Development
The transgene consists of a beta-galactosidase reporter gene under the control of a modified murine endothelial-specific receptor tyrosine kinase (Tek/Tie2) promoter. Targeted mutation of recombination activating gene-1 (Rag1) resulted in a 1356 base pair deletion in the 5' end of the endogenous coding sequence and PGK-Neo cassette insertion. Double mutant mice were generated by crossing homozygous female B6.129S7-Rag1tm1Mom/J (see Stock No. 002216) with hemizygous male FVB/N-Tg(TIE2-lacZ)182Sato/J (see Stock No. 002856) mice. Female progeny were then mated to males homozygous for the Rag1 mutation to fix Rag1-deficiency. Subsequent sibling intercross resulted in presumed homozygosity of the transgene on chromosome X (via test crosses to wildtype). Other transgene insertion points on autosomes are likely.
Control Information
| Control | ||
|---|---|---|
| None Available | ||
| Considerations for Choosing Controls | ||
Related Strains
lacZ Expression Strains
View lacZ Expression Strains (186 strains)
002856 FVB/N-Tg(TIE2-lacZ)182Sato/J
007790 B6;129P2-Rag1/Rag2tm1Mnz/J 002194 B6;CBA-Tg(CD3E)26Cpt/J 002506 STOCK Tg(CD3E)26Cpt-Rag1tm1Mom/J
004128 B6.Cg-Tg(Tek-cre)12Flv/J 008863 B6.Cg-Tg(Tek-cre)1Ywa/J 008537 FVB-Tg(Tek-cre)2352Rwng/J 006770 STOCK Rag1tm1Mom Tg(TIE2GFP)287Sato/J 003658 STOCK Tg(TIE2GFP)287Sato/J
Additional Web Information
Fluorescent Proteins/lacZ Systems
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
lacZ relatedCancer Research
Toxicology
B and T cell deficiency, xenograft/transplant host
Immunology and Inflammation Research
Immunodeficiency
B and T cell deficiency
Research Tools
lacZ Expression
Cancer Research
B and T cell deficiency, xenograft/transplant host
endothelial cell marker for neovascularization
xenograft/transplant host
Cardiovascular Research
endothelial cell marker (lacZ) for neovascularization
endothelial cell marker for neovascularization
Genetics Research
Tissue/Cell Markers: endothelial cell markers for neovascularization
Tissue/Cell Markers: endothelial cells
Immunology and Inflammation Research
T cell deficiency, xenograft/transplant host
Toxicology Research
B and T cell deficiency, xenograft transplant host
Rag1tm1Mom relatedResearch Tools
lacZ Expression
Cancer Research
Toxicology
B and T cell deficiency, xenograft/transplant host
Hematological Research
Immunological Defects
B and T cell deficiency
Immunology and Inflammation Research
Immunodeficiency
B and T cell deficiency
Inflammation
B and T cell deficiency
T Cell Receptor Signaling Defects
B and T cell deficiency
Internal/Organ Research
Lymphoid Tissue Defects
B and T cell deficiency
Research Tools
Cancer Research
B and T cell deficiency, xenograft/transplant host
Toxicology Research
xenograft/transplant host
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Rag1tm1Mom | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Peter Mombaerts | ||
| Allele Type | Targeted (knock-out) | ||
| Common Name(s) | RAG-1-; RAG1null; Rag-; Rag-1KO; Rag1-; | ||
| Mutation Made By | Peter Mombaerts, Max Planck Institute of Biophysics | ||
| Strain of Origin | 129S7/SvEvBrd-Hprt1<+> | ||
| ES Cell Line Name | AB1 | ||
| ES Cell Line Strain | 129S7/SvEvBrd-Hprt1<+> | ||
| Gene Symbol and Name | Rag1, recombination activating gene 1 | ||
| Chromosome | 2 | ||
| Gene Common Name(s) | MGC43321; RNF74; Rag-1; | ||
| Molecular Note | A 1356 bp genomic fragment of the Rag1 gene, encoding the nuclear localization signal and the zinc-finger motif, was replaced by a neomycin cassette. A mutant transcript expressed from this allele was detected by Northern blot in bone marrow derived cell lines from homozygous mice. [MGI Ref ID J:1934] [MGI Ref ID J:96036] | ||
| Allele Symbol | Tg(TIE2-lacZ)182Sato | ||
| Allele Name | transgene insertion 182, Thomas N Sato | ||
| Allele Type | Transgenic (Reporter) | ||
| Common Name(s) | TIE2p/e-LacZ; Tg(TIE2LacZ)182Sato; Tg182Sato; Tie2-lacZ; Tie2/LacZ; | ||
| Mutation Made By | Thomas Sato, Weill Medical College of Cornell Univ | ||
| Site of Expression | lacZ expression is detected in endothelial cells. | ||
| Expressed Gene | lacZ, beta-galactosidase, E. coli | ||
| Promoter | Tek, endothelial-specific receptor tyrosine kinase, mouse, laboratory | ||
| General Note | In embryonic and adult transgenic mice on an FVB/N background, LacZ is expressed specifically in vascular endothelial cells. | ||
| Molecular Note | The transgene consists of a mouse Tek promoter and enhancer element, a lacZ reporter gene, and an SV40 polyadenylation sequence. The enhancer element is a genomic fragment extending from 3' of exon 1 to 10 kb into intron 1. Expression was driven in endothelial cells. [MGI Ref ID J:39276] | ||
| Gene Symbol and Name | Tg(TIE2-lacZ)182Sato, transgene insertion 182, Thomas N Sato | ||
| Chromosome | UN | ||
| Gene Common Name(s) | Tg(TIE2LacZ)182Sato; Tg182Sato; Tie2-lacZ; Tie2/LacZ; | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic LacZ QPCR, QPCR
Generic LacZ, Standard PCR
Rag1tm1Mom, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Fathers KE; Stone CM; Minhas K; Marriott JJ; Greenwood JD; Dumont DJ; Coomber BL. 2005. Heterogeneity of Tie2 expression in tumor microcirculation: influence of cancer type, implantation site, and response to therapy. Am J Pathol 167(6):1753-62. [PubMed: 16314485] [MGI Ref ID J:107320]
Additional References
Rag1tm1Mom relatedTg(TIE2-lacZ)182Sato relatedAhn S; Lee G; Yang SJ; Lee D; Lee S; Shin HS; Kim MC; Lee KN; Palmer DC; Theoret MR; Jenkinson EJ; Anderson G; Restifo NP; Kim MG. 2008. TSCOT+ thymic epithelial cell-mediated sensitive CD4 tolerance by direct presentation. PLoS Biol 6(8):e191. [PubMed: 18684012] [MGI Ref ID J:140121]
Ait-Azzouzene D; Verkoczy L; Peters J; Gavin A; Skog P; Vela JL; Nemazee D. 2005. An immunoglobulin C{kappa}-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system. J Exp Med 201(5):817-28. [PubMed: 15738053] [MGI Ref ID J:96759]
Alugupalli KR; Gerstein RM; Chen J; Szomolanyi-Tsuda E; Woodland RT; Leong JM. 2003. The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes. J Immunol 170(7):3819-27. [PubMed: 12646649] [MGI Ref ID J:125443]
Alugupalli KR; Leong JM; Woodland RT; Muramatsu M; Honjo T; Gerstein RM. 2004. B1b lymphocytes confer T cell-independent long-lasting immunity. Immunity 21(3):379-90. [PubMed: 15357949] [MGI Ref ID J:93752]
Anderson MG; Nair KS; Amonoo LA; Mehalow A; Trantow CM; Masli S; John SW. 2008. GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma. BMC Genet 9:30. [PubMed: 18402690] [MGI Ref ID J:134670]
Anginot A; Dacquin R; Mazzorana M; Jurdic P. 2007. Lymphocytes and the Dap12 adaptor are key regulators of osteoclast activation associated with gonadal failure. PLoS ONE 2(7):e585. [PubMed: 17611620] [MGI Ref ID J:129304]
Antony PA; Piccirillo CA; Akpinarli A; Finkelstein SE; Speiss PJ; Surman DR; Palmer DC; Chan CC; Klebanoff CA; Overwijk WW; Rosenberg SA; Restifo NP. 2005. CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells. J Immunol 174(5):2591-601. [PubMed: 15728465] [MGI Ref ID J:129825]
Assarsson E; Chambers BJ; Hogstrand K; Berntman E; Lundmark C; Fedorova L; Imreh S; Grandien A; Cardell S; Rozell B; Ljunggren HG. 2007. Severe defect in thymic development in an insertional mutant mouse model. J Immunol 178(8):5018-27. [PubMed: 17404284] [MGI Ref ID J:145284]
Aurora AB; Baluk P; Zhang D; Sidhu SS; Dolganov GM; Basbaum C; McDonald DM; Killeen N. 2005. Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection. J Immunol 175(10):6319-26. [PubMed: 16272283] [MGI Ref ID J:119344]
Baccala R; Witherden D; Gonzalez-Quintial R; Dummer W; Surh CD; Havran WL; Theofilopoulos AN. 2005. Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors. J Immunol 174(8):4606-12. [PubMed: 15814683] [MGI Ref ID J:98166]
Backhed F; Ding H; Wang T; Hooper LV; Koh GY; Nagy A; Semenkovich CF; Gordon JI. 2004. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A 101(44):15718-23. [PubMed: 15505215] [MGI Ref ID J:93455]
Bajou K; Peng H; Laug WE; Maillard C; Noel A; Foidart JM; Martial JA; DeClerck YA. 2008. Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis. Cancer Cell 14(4):324-34. [PubMed: 18835034] [MGI Ref ID J:140088]
Banuelos SJ; Shultz LD; Greiner DL; Burzenski LM; Gott B; Lyons BL; Rossini AA; Appel MC. 2004. Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice. Clin Immunol 112(3):273-83. [PubMed: 15308121] [MGI Ref ID J:91764]
Barjaktarevic I; Rahman A; Radoja S; Bogunovic B; Vollmer A; Vukmanovic S; Maric M. 2006. Inhibitory role of IFN-gamma-inducible lysosomal thiol reductase in T cell activation. J Immunol 177(7):4369-75. [PubMed: 16982871] [MGI Ref ID J:139329]
Bassetti MF; White J; Kappler JW; Marrack P. 2009. Transgenic Bcl-3 slows T cell proliferation. Int Immunol 21(4):339-48. [PubMed: 19208752] [MGI Ref ID J:147105]
Beilke JN; Kuhl NR; Van Kaer L; Gill RG. 2005. NK cells promote islet allograft tolerance via a perforin-dependent mechanism. Nat Med 11(10):1059-65. [PubMed: 16155578] [MGI Ref ID J:101693]
Belkaid Y; Von Stebut E; Mendez S; Lira R; Caler E; Bertholet S; Udey MC; Sacks D. 2002. CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major. J Immunol 168(8):3992-4000. [PubMed: 11937556] [MGI Ref ID J:125458]
Bergstrom KS; Guttman JA; Rumi M; Ma C; Bouzari S; Khan MA; Gibson DL; Vogl AW; Vallance BA. 2008. Modulation of intestinal goblet cell function during infection by an attaching and effacing bacterial pathogen. Infect Immun 76(2):796-811. [PubMed: 17984203] [MGI Ref ID J:130255]
Bessler M; Rosti V; Peng Y; Cattoretti G; Notaro R; Ohsako S; Elkon KB; Luzzatto L. 2002. Glycosylphosphatidylinositol-linked proteins are required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development. Eur J Immunol 32(9):2607-16. [PubMed: 12207345] [MGI Ref ID J:78996]
Bettelli E; Pagany M; Weiner HL; Linington C; Sobel RA; Kuchroo VK. 2003. Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J Exp Med 197(9):1073-81. [PubMed: 12732654] [MGI Ref ID J:83278]
Binder GK; Griffin DE. 2001. Interferon-gamma-mediated site-specific clearance of alphavirus from CNS neurons. Science 293(5528):303-6. [PubMed: 11452126] [MGI Ref ID J:125465]
Binstadt BA; Hebert JL; Ortiz-Lopez A; Bronson R; Benoist C; Mathis D. 2009. The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms. Proc Natl Acad Sci U S A 106(39):16758-63. [PubMed: 19805369] [MGI Ref ID J:153217]
Bizargity P; Del Rio R; Phillippe M; Teuscher C; Bonney EA. 2009. Resistance to lipopolysaccharide-induced preterm delivery mediated by regulatory T cell function in mice. Biol Reprod 80(5):874-81. [PubMed: 19144956] [MGI Ref ID J:149636]
Block MS; Mendez-Fernandez YV; Van Keulen VP; Hansen MJ; Allen KS; Taboas AL; Rodriguez M; Pease LR. 2005. Inability of bm14 mice to respond to Theiler's murine encephalomyelitis virus is caused by defective antigen presentation, not repertoire selection. J Immunol 174(5):2756-62. [PubMed: 15728484] [MGI Ref ID J:97717]
Borghesi L; Hsu LY; Miller JP; Anderson M; Herzenberg L; Herzenberg L; Schlissel MS; Allman D; Gerstein RM. 2004. B lineage-specific regulation of V(D)J recombinase activity is established in common lymphoid progenitors. J Exp Med 199(4):491-502. [PubMed: 14769852] [MGI Ref ID J:119401]
Bour-Jordan H; Salomon BL; Thompson HL; Szot GL; Bernhard MR; Bluestone JA. 2004. Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells. J Clin Invest 114(7):979-87. [PubMed: 15467837] [MGI Ref ID J:93421]
Brien JD; Uhrlaub JL; Nikolich-Zugich J. 2008. West nile virus-specific CD4 T cells exhibit direct antiviral cytokine secretion and cytotoxicity and are sufficient for antiviral protection. J Immunol 181(12):8568-75. [PubMed: 19050276] [MGI Ref ID J:142059]
Brochard V; Combadiere B; Prigent A; Laouar Y; Perrin A; Beray-Berthat V; Bonduelle O; Alvarez-Fischer D; Callebert J; Launay JM; Duyckaerts C; Flavell RA; Hirsch EC; Hunot S. 2009. Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. J Clin Invest 119(1):182-92. [PubMed: 19104149] [MGI Ref ID J:144702]
Broxmeyer HE; Sehra S; Cooper S; Toney LM; Kusam S; Aloor JJ; Marchal CC; Dinauer MC; Dent AL. 2007. Aberrant regulation of hematopoiesis by T cells in BAZF-deficient mice. Mol Cell Biol 27(15):5275-85. [PubMed: 17526724] [MGI Ref ID J:123621]
Brydges SD; Mueller JL; McGeough MD; Pena CA; Misaghi A; Gandhi C; Putnam CD; Boyle DL; Firestein GS; Horner AA; Soroosh P; Watford WT; O'Shea JJ; Kastner DL; Hoffman HM. 2009. Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity 30(6):875-87. [PubMed: 19501000] [MGI Ref ID J:150054]
Burich A; Hershberg R; Waggie K; Zeng W; Brabb T; Westrich G; Viney JL; Maggio-Price L. 2001. Helicobacter-induced inflammatory bowel disease in IL-10- and T cell-deficient mice. Am J Physiol Gastrointest Liver Physiol 281(3):G764-78. [PubMed: 11518689] [MGI Ref ID J:108283]
Cao Y; Luo JL; Karin M. 2007. IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells. Proc Natl Acad Sci U S A 104(40):15852-7. [PubMed: 17890319] [MGI Ref ID J:125555]
Carrio R; Rolle CE; Malek TR. 2007. Non-redundant role for IL-7R signaling for the survival of CD8(+) memory T cells. Eur J Immunol 37(11):3078-88. [PubMed: 17935075] [MGI Ref ID J:126334]
Cernetich A; Garver LS; Jedlicka AE; Klein PW; Kumar N; Scott AL; Klein SL. 2006. Involvement of gonadal steroids and gamma interferon in sex differences in response to blood-stage malaria infection. Infect Immun 74(6):3190-203. [PubMed: 16714546] [MGI Ref ID J:109239]
Chang X; Zheng P; Liu Y. 2008. Homeostatic proliferation in the mice with germline FoxP3 mutation and its contribution to fatal autoimmunity. J Immunol 181(4):2399-406. [PubMed: 18684929] [MGI Ref ID J:140191]
Chao TK; Rifai A; Ka SM; Yang SM; Shui HA; Lin YF; Sytwu HK; Lee WH; Kung JT; Chen A. 2006. The endogenous immune response modulates the course of IgA-immune complex mediated nephropathy. Kidney Int 70(2):283-97. [PubMed: 16738538] [MGI Ref ID J:136494]
Chatterjee G; Carrithers LM; Carrithers MD. 2008. Epithelial V-like antigen regulates permeability of the blood-CSF barrier. Biochem Biophys Res Commun 372(3):412-7. [PubMed: 18498762] [MGI Ref ID J:137884]
Chen BP; Kuziel WA; Lane TE. 2001. Lack of CCR2 results in increased mortality and impaired leukocyte activation and trafficking following infection of the central nervous system with a neurotropic coronavirus. J Immunol 167(8):4585-92. [PubMed: 11591787] [MGI Ref ID J:106738]
Chen M; Lichtler AC; Sheu TJ; Xie C; Zhang X; O'Keefe RJ; Chen D. 2007. Generation of a transgenic mouse model with chondrocyte-specific and tamoxifen-inducible expression of Cre recombinase. Genesis 45(1):44-50. [PubMed: 17211877] [MGI Ref ID J:117868]
Chen Q; Sen G; Snapper CM. 2006. Endogenous IL-1R1 signaling is critical for cognate CD4+ T cell help for induction of in vivo type 1 and type 2 antipolysaccharide and antiprotein Ig isotype responses to intact Streptococcus pneumoniae, but not to a soluble pneumococcal conjugate vaccine. J Immunol 177(9):6044-51. [PubMed: 17056530] [MGI Ref ID J:140525]
Chen R; Fairley JA; Zhao ML; Giudice GJ; Zillikens D; Diaz LA; Liu Z. 2002. Macrophages, but not T and B lymphocytes, are critical for subepidermal blister formation in experimental bullous pemphigoid: macrophage-mediated neutrophil infiltration depends on mast cell activation. J Immunol 169(7):3987-92. [PubMed: 12244200] [MGI Ref ID J:120403]
Christopher K; Liang Y; Mueller TF; DeFina R; He H; Haley KJ; Exley MA; Finn PW; Perkins DL. 2004. Analysis of the major histocompatibility complex in graft rejection revisited by gene expression profiles. Transplantation 78(6):788-98. [PubMed: 15385796] [MGI Ref ID J:98356]
Chung Y; Chang SH; Martinez GJ; Yang XO; Nurieva R; Kang HS; Ma L; Watowich SS; Jetten AM; Tian Q; Dong C. 2009. Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity 30(4):576-87. [PubMed: 19362022] [MGI Ref ID J:147961]
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Corre I; Gomez M; Vielkind S; Cantrell DA. 2001. Analysis of thymocyte development reveals that the GTPase RhoA is a positive regulator of T cell receptor responses in vivo. J Exp Med 194(7):903-14. [PubMed: 11581313] [MGI Ref ID J:134058]
Crompton T; Gilmour KC; Owen MJ. 1996. The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte. Cell 86(2):243-51. [PubMed: 8706129] [MGI Ref ID J:34462]
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Curotto de Lafaille MA; Muriglan S; Sunshine MJ; Lei Y; Kutchukhidze N; Furtado GC; Wensky AK; Olivares-Villagomez D; Lafaille JJ. 2001. Hyper immunoglobulin E response in mice with monoclonal populations of B and T lymphocytes. J Exp Med 194(9):1349-59. [PubMed: 11696599] [MGI Ref ID J:100072]
Cushman J; Lo J; Huang Z; Wasserfall C; Petitto JM. 2003. Neurobehavioral changes resulting from recombinase activation gene 1 deletion. Clin Diagn Lab Immunol 10(1):13-8. [PubMed: 12522033] [MGI Ref ID J:102410]
Dardalhon V; Awasthi A; Kwon H; Galileos G; Gao W; Sobel RA; Mitsdoerffer M; Strom TB; Elyaman W; Ho IC; Khoury S; Oukka M; Kuchroo VK. 2008. IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol 9(12):1347-55. [PubMed: 18997793] [MGI Ref ID J:143168]
Das G; Augustine MM; Das J; Bottomly K; Ray P; Ray A. 2003. An important regulatory role for CD4+CD8 alpha alpha T cells in the intestinal epithelial layer in the prevention of inflammatory bowel disease. Proc Natl Acad Sci U S A 100(9):5324-9. [PubMed: 12695566] [MGI Ref ID J:83283]
De Jersey J; Carmignac D; Le Tissier P; Barthlott T; Robinson I; Stockinger B. 2004. Factors affecting the susceptibility of the mouse pituitary gland to CD8 T-cell-mediated autoimmunity. Immunology 111(3):254-61. [PubMed: 15009425] [MGI Ref ID J:131885]
DeNardo DG; Barreto JB; Andreu P; Vasquez L; Tawfik D; Kolhatkar N; Coussens LM. 2009. CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell 16(2):91-102. [PubMed: 19647220] [MGI Ref ID J:151976]
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Dimayuga PC; Li H; Chyu KY; Fredrikson GN; Nilsson J; Fishbein MC; Shah PK; Cercek B. 2005. T cell modulation of intimal thickening after vascular injury: the bimodal role of IFN-gamma in immune deficiency. Arterioscler Thromb Vasc Biol 25(12):2528-34. [PubMed: 16224059] [MGI Ref ID J:116822]
Divangahi M; Chen M; Gan H; Desjardins D; Hickman TT; Lee DM; Fortune S; Behar SM; Remold HG. 2009. Mycobacterium tuberculosis evades macrophage defenses by inhibiting plasma membrane repair. Nat Immunol 10(8):899-906. [PubMed: 19561612] [MGI Ref ID J:151654]
Dokun AO; Chu DT; Yang L; Bendelac AS; Yokoyama WM. 2001. Analysis of in situ NK cell responses during viral infection. J Immunol 167(9):5286-93. [PubMed: 11673544] [MGI Ref ID J:72673]
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Edgerton C; Crispin JC; Moratz CM; Bettelli E; Oukka M; Simovic M; Zacharia A; Egan R; Chen J; Dalle Lucca JJ; Juang YT; Tsokos GC. 2009. IL-17 producing CD4+ T cells mediate accelerated ischemia/reperfusion-induced injury in autoimmunity-prone mice. Clin Immunol 130(3):313-21. [PubMed: 19058762] [MGI Ref ID J:145181]
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El Andaloussi A; Graves S; Meng F; Mandal M; Mashayekhi M; Aifantis I. 2006. Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus. Nat Immunol 7(4):418-26. [PubMed: 16518394] [MGI Ref ID J:112555]
Engwerda CR; Ato M; Stager S; Alexander CE; Stanley AC; Kaye PM. 2004. Distinct roles for lymphotoxin-alpha and tumor necrosis factor in the control of Leishmania donovani infection. Am J Pathol 165(6):2123-33. [PubMed: 15579454] [MGI Ref ID J:94946]
Esplin BL; Welner RS; Zhang Q; Borghesi LA; Kincade PW. 2009. A differentiation pathway for B1 cells in adult bone marrow. Proc Natl Acad Sci U S A 106(14):5773-8. [PubMed: 19307589] [MGI Ref ID J:147564]
Fan Y; Rudert WA; Grupillo M; He J; Sisino G; Trucco M. 2009. Thymus-specific deletion of insulin induces autoimmune diabetes. EMBO J 28(18):2812-24. [PubMed: 19680229] [MGI Ref ID J:152798]
Fantini MC; Rizzo A; Fina D; Caruso R; Sarra M; Stolfi C; Becker C; Macdonald TT; Pallone F; Neurath MF; Monteleone G. 2009. Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression. Gastroenterology 136(4):1308-16, e1-3. [PubMed: 19192480] [MGI Ref ID J:148211]
Feng N; Kim B; Fenaux M; Nguyen H; Vo P; Omary MB; Greenberg HB. 2008. Role of interferon in homologous and heterologous rotavirus infection in the intestines and extraintestinal organs of suckling mice. J Virol 82(15):7578-90. [PubMed: 18495762] [MGI Ref ID J:153415]
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Lindsay EA; Baldini A. 2001. Recovery from arterial growth delay reduces penetrance of cardiovascular defects in mice deleted for the DiGeorge syndrome region. Hum Mol Genet 10(9):997-1002. [PubMed: 11309372] [MGI Ref ID J:119454]
Makinen T; Adams RH; Bailey J; Lu Q; Ziemiecki A; Alitalo K; Klein R; Wilkinson GA. 2005. PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature. Genes Dev 19(3):397-410. [PubMed: 15687262] [MGI Ref ID J:95885]
Mayr U; Zou Y; Zhang Z; Dietrich H; Hu Y; Xu Q. 2006. Accelerated arteriosclerosis of vein grafts in inducible NO synthase(-/-) mice is related to decreased endothelial progenitor cell repair. Circ Res 98(3):412-20. [PubMed: 16385078] [MGI Ref ID J:118879]
Morimoto H; Takahashi M; Izawa A; Ise H; Hongo M; Kolattukudy PE; Ikeda U. 2006. Cardiac overexpression of monocyte chemoattractant protein-1 in transgenic mice prevents cardiac dysfunction and remodeling after myocardial infarction. Circ Res 99(8):891-9. [PubMed: 16990567] [MGI Ref ID J:126503]
Parmar N; Berry LR; Post M; Chan AK. 2009. Effect of covalent antithrombin-heparin complex on developmental mechanisms in the lung. Am J Physiol Lung Cell Mol Physiol 296(3):L394-403. [PubMed: 19112103] [MGI Ref ID J:146359]
Qin G; Ii M; Silver M; Wecker A; Bord E; Ma H; Gavin M; Goukassian DA; Yoon YS; Papayannopoulou T; Asahara T; Kearney M; Thorne T; Curry C; Eaton L; Heyd L; Dinesh D; Kishore R; Zhu Y; Losordo DW. 2006. Functional disruption of alpha4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization. J Exp Med 203(1):153-63. [PubMed: 16401693] [MGI Ref ID J:118824]
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Health & husbandry
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Health & Colony Maintenance Information
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, these mice are bred as homozygous for both the targeted mutation and the transgene. Specific pathogen free conditions are recommended as these mice are immunodeficient (lack mature B and T lymphocytes). Donating investigator reports occasional abnormalities at their facility; mice can agressively barber their cagemates, have tooth malocclusion at weaning, and a few develop 'crystal pneumonitis'.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 Cryopreserved Embryos $1600.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
| Pricing for International shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 Cryopreserved Embryos $2080.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
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Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| None Available | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
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| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.