Former Names B6.Cg-H2g7-Tg(Ins2-CD80)3B7Flv/LwnJ (Changed: 28-SEP-06 ) B6.Cg H2g7-Tg(Ins2-CD80)3B7Flv/FswJ (Changed: 07-MAR-06 ) Type Congenic; Major Histocompatibility Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Background Strain B6.NOD-H2g7 Donor Strain (C57BL/6 X CBA)F2 H2 Haplotype g7 Generation N?F9+F2pN1
Generation DefinitionsDonating Investigator Li Wen, Yale School of Medicine Appearance
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Related Genotype: a/aDescription
Transgenic mice are characterized by pancreatic beta cells that express a rat insulin promoter (Ins2) regulated transgene encoding the human CD80 T cell co-stimulatory molecule. These mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. Better than 70% of the B6.H2g7 transgenic mice become diabetic by 30 weeks of age compared the control B6.H2g7 which does not develop insulitis or diabetes. Spleens of diabetic B6.H2g7 transgenic mice used in adoptive transfer experiments transfer diabetes to NOD.scid/RIP-B7.1 and irradiated non-diabetic B6.Cg H2g7-Tg(Ins2-CD80)3B7Flv/LwnJ mice, yet failed to transfer disease to NOD.scid, B6.scid, CB17.scid, or irradiated B6/RIP-B7.1.B6.Cg H2g7-Tg(Ins2-CD80)3B7Flv/LwnJ provides a tool for studying mechanisms of loss of tolerance in potentially diabetogenic CD8 T-cells.
Development
A transgenic construct containing the human CD80 gene driven by the rat insulin promoter 1 (RIP) was injected fertilized eggs of a mating between C57BL/6 and CBA/Ca strains in the laboratory of Dr. Richard Flavell (Yale University). Founder animals were obtained and bred to C57BL/6 mice for more than 10 generations and subsequently mated to NOR/Lt or BALB/c for 10 generations and B6.NOD-H2g7 for 1 generation. In 2005, The Jackson Laboratory received this B6.Cg H2g7-Tg(Ins2-CD80)3B7Flv/LwnJ at N1F9.
| Control | ||
|---|---|---|
| 003300 B6.NOD-(D17Mit21-D17Mit10)/LtJ | (approximate) | |
| Considerations for Choosing Controls | ||
Strains carrying H2g7 allele
003851 ALR.NOD-(D17Mit30-D17Mit123)/Lt 010972 B10.NOD-(rs13459152-rs13483054)/1107MrkJ 005717 B6(NOD) H2g7-Sostdc1shk/J 003068 B6.NOD-(Csf2-D11Mit42) (D17Mit21-D17Mit10)/J 004554 B6.NOD-(D17Mit21-D17Mit10) Tg(TCRaAI4)1Dvs/DvsJ 004555 B6.NOD-(D17Mit21-D17Mit10) Tg(TCRbAI4)1Dvs/DvsJ 003300 B6.NOD-(D17Mit21-D17Mit10)/LtJ 003069 B6.NOD-(D1Mit3-Bcl2) (D17Mit21-D17Mit10)/LtJ 003071 B6.NOD-(D1Mit5.1-D1Mit15) (D17Mit21-D17Mit10)/J 003067 B6.NOD-(D3Mit132-Tshb) (D17Mit21-D17Mit10)/J 003066 B6.NOD-(D6Mit54-D6Mit14) (D17Mit21-D17Mit10)/J 001627 NON.NOD-H2g7/LtJ View Strains carrying H2g7 (12 strains)
Strains carrying Tg(Ins2-CD80)3B7Flv allele
005713 C.Cg-Tg(Ins2-CD80)3B7Flv/LwnJ 004346 NOD.Cg-Prkdcscid Tg(Ins2-CD80)3B7Flv/DvsJ 005714 NOR.Cg-Tg(Ins2-CD80)3B7Flv/LwnJ View Strains carrying Tg(Ins2-CD80)3B7Flv (3 strains)
Strains carrying other alleles of CD80
005713 C.Cg-Tg(Ins2-CD80)3B7Flv/LwnJ 004346 NOD.Cg-Prkdcscid Tg(Ins2-CD80)3B7Flv/DvsJ 006778 NOD/ShiLt-Tg(GFAP-Cd80)9Mdos/MdosJ 005714 NOR.Cg-Tg(Ins2-CD80)3B7Flv/LwnJ View Strains carrying other alleles of CD80 (4 strains)
Strains carrying other alleles of H2
006500 129.NOD-(D17Mit175-H2)/J 001649 A.BY H2bc H2-T18f/SnJ-Dstncorn1/J 000140 A.BY-H2bc H2-T18f/SnJ 000472 A.CA-H2f H2-T18a/SnJ 000471 A.SW-H2s H2-T18b/SnJ 001066 A.TH-H2t2/SfDvEgMobJ 001067 A.TL-H2t1/SfDvEgMobJ 002089 AK.B6-H2b Fv1b/J 002090 AK.B6-H2b/J 001094 AK.L-H2b/1CyTyJ 001095 AK.L-H2oz2/CyJ 001096 AK.L-H2oz3/CyJ 000470 AK.M-H2m H2-T18a/nSnJ 003851 ALR.NOD-(D17Mit30-D17Mit123)/Lt 000469 B10.A-H2a H2-T18a/SgSnJ 000468 B10.A-H2h2/(2R)SgSnJ 001150 B10.A-H2h4/(4R)SgDvEgJ 001149 B10.A-H2i3/(3R)SgDvEgJ 000467 B10.A-H2i5 H2-T18a/(5R)SgSnJ 000466 B10.AKM-H2m H2-T18a/SnJ 001954 B10.AQR-H2y1/KljMcdJ 000465 B10.BR-H2k2 H2-T18a/SgSnJ 004804 B10.BR-H2k H2-T18a/SgSnJJrep 005308 B10.Cg-H2d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ 005534 B10.Cg-H2d Tg(Ins2-HA)165Bri/ShrmJ 010514 B10.Cg-H2g Tg(Cd4-Klra1)6295Dl/J 006446 B10.Cg-H2h4 Sh3pxd2bnee/GrsrJ 006100 B10.Cg-H2k Tg(NFkB/Fos-luc)26Rinc/J 006102 B10.Cg-H2k Tg(Il2/NFAT-luc)83Rinc/J 005895 B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J 002024 B10.D1-H2q/SgJ 001163 B10.D2-H2bm23/EgJ 000462 B10.D2-H2d/n2SnJ 001164 B10.D2-H2dm1/EgJ 001151 B10.D2-H2g3/(103R)EgJ 001153 B10.D2-H2i7/(107R)EgJ 001152 B10.D2-H2ia/(106R)EgJ 000460 B10.D2-Hc0 H2d H2-T18c/o2SnJ 000461 B10.D2-Hc0 H2d H2-T18c/oSnJ 000463 B10.D2-Hc1 H2d H2-T18c/nSnJ 003147 B10.D2-Hc1 H2d H2-T18c/nSnJ-Tg(DO11.10)10Dlo/J 000464 B10.DA-H2qp1 H2-T18b/(80NS)SnJ 001823 B10.F-H2bp5/(14R)J 001818 B10.F-H2pb1/(13R)J 001012 B10.HTG-H2g/2CyJ 000999 B10.HTG-H2g/3CyJ 001894 B10.LG-H2ar1/J 000459 B10.M-H2f H2-T18a?/SnJ 002225 B10.M-H2f/nMob Fmn1ld-2J/J 001068 B10.M-H2f/nMobJ 000739 B10.M-H2fm2/MobJ 001154 B10.MBR-H2bq1/SxEgJ 010972 B10.NOD-(rs13459152-rs13483054)/1107MrkJ 001825 B10.P-H2kp1/(10R)SgJ 003199 B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRA)B1Jg/J 003200 B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRB)C14Jg/J 000458 B10.PL-H2u H2-T18a/(73NS)SnJ 000457 B10.RIII-H2r H2-T18b/(71NS)SnJ 001069 B10.RIII-H2r/(71NS)nMobJ 001760 B10.S-H2as1/(8R)/J 001953 B10.S-H2s/SgMcdJ 001817 B10.S-H2sm1/(12R)SgJ 001650 B10.S-H2t4/(9R)/J 000456 B10.SM H2v H2-T18b/(70NS)Sn-cw/J 001155 B10.T-H2y2/(6R)SgDvEgJ 000445 B10.WB-H2j H2-T18b/SnJ 000444 B10.Y-H2pa H2-T18c/SnJ 003483 B6 x B10.D1-H2q/SgJ-Nox3het-2J/J 003561 B6 x B10.PL-H2u/(73NS)Sn-Hxl/J 002995 B6 x C.B10-H2b/LiMcdJ-Fbn2fp-2J/J 005717 B6(NOD) H2g7-Sostdc1shk/J 003584 B6.129S2-H2dlAb1-Ea/J 001148 B6.AK-H2k/FlaEgJ 001895 B6.AK-H2k/J 001160 B6.C-H2bm10/KhEgJ 001161 B6.C-H2bm11/KhEgJ 000364 B6.C-H2bm2/ByJ 000369 B6.C-H2bm4/ByJ 001158 B6.C-H2bm7/KhEgJ 000360 B6.C-H2d Mdmg1BALB/cBy/aByJ 000359 B6.C-H2d/bByJ 001429 B6.C-H2g6/J 007958 B6.Cg-H2b3/FlaCmwJ 007959 B6.Cg-H2b4/FlaCmwJ 003068 B6.NOD-(Csf2-D11Mit42) (D17Mit21-D17Mit10)/J 004554 B6.NOD-(D17Mit21-D17Mit10) Tg(TCRaAI4)1Dvs/DvsJ 004555 B6.NOD-(D17Mit21-D17Mit10) Tg(TCRbAI4)1Dvs/DvsJ 003300 B6.NOD-(D17Mit21-D17Mit10)/LtJ 003069 B6.NOD-(D1Mit3-Bcl2) (D17Mit21-D17Mit10)/LtJ 003071 B6.NOD-(D1Mit5.1-D1Mit15) (D17Mit21-D17Mit10)/J 003067 B6.NOD-(D3Mit132-Tshb) (D17Mit21-D17Mit10)/J 003066 B6.NOD-(D6Mit54-D6Mit14) (D17Mit21-D17Mit10)/J 000944 B6.SJL-H2b C3c/2CyJ 000966 B6.SJL-H2s C3c/1CyJ 000945 B6.SW/1CyJ 003374 B6;129S2-H2dlAb1-Ea/J 003240 B6;B10.A-H2a-Tg(H2KmPCC)2939Stoe/J 002844 BALB.5R-H2i5/LilJ 001165 BALB/c-H2dm2/KhEgJ 001041 BKS.B6-H2b/J 001892 BRVR.B10-H2b/J 001893 BRVR.D2-H2d/J 002845 C.B-H2b Tg(H2-Dd)D8Gja/LilJ 001952 C.B10-H2b/LilMcdJ 001768 C3.Cg-Irs1Sml H2b/GrsrJ 000443 C3.HTG-H2g H2-T18b?/SnJ 000441 C3.JK-H2j H2-T18b/SnJ 000440 C3.LG-H2ar1/CkcCyJ 000439 C3.NB-H2p H2-T18c?/SnJ 000438 C3.SW-H2b/SnJ 000473 C3H-H2o2 C4bb/SfSnJ 001156 C57BL/6J-H2bm3/EgJ 001157 C57BL/6Kh-H2bm5/KhEgJ 000437 D1.C-H2d H2-T18c/SnJ 000436 D1.DA-H2qp1/SnJ 000435 D1.LP-H2b H2-T18b?/SnJ 000434 LP.RIII-H2r H2-T18b/SnJ 001383 LT.MA-Glo1b H2k/J 002591 NOD.B10Sn-H2b/J 006935 NOD.Cg-H2b thnh/J 004447 NOD.Cg-H2h4/DilTacUmmJ 001626 NOD.NON-H2nb1/LtJ 002032 NOD.SW-H2q/J 001627 NON.NOD-H2g7/LtJ 002974 STOCK Ces1ce H2d/J 001308 STOCK H2473a/J 003153 WLC.C-H2d.GR-Mtv2/MorJ 003154 WLC.C-H2d/MorJ View Strains carrying other alleles of H2 (128 strains)
Strains carrying other alleles of Ins2
005534 B10.Cg-H2d Tg(Ins2-HA)165Bri/ShrmJ 005500 B6.C-Tg(Ins2-GP)34-20Olds/MvhJ 004826 B6.Cg-Tg(Ins2-NP)25-3Olds/MhvJ 003573 B6.Cg-Tg(Ins2-cre)25Mgn/J 005713 C.Cg-Tg(Ins2-CD80)3B7Flv/LwnJ 005533 C.Cg-Tg(Ins2-HA)165Bri/ShrmJ 004827 C.Cg-Tg(Ins2-NP)25-3Olds/MvhJ 005432 C57BL/6-Tg(Ins2-OVA)307Wehi/WehiJ 005433 C57BL/6-Tg(Ins2-OVA)59Wehi/WehiJ 005431 C57BL/6-Tg(Ins2-TFRC/OVA)296Wehi/WehiJ 005564 FVB(Cg)-Tg(Ins2-CALM1)26Ove Tg(Cryaa-TAg)1Ove/PneJ 008232 FVB/N-Tg(Ins2-IAPP)RHFSoel/J 005522 NOD-Tg(Ins2*Y16A)1Ell/GseJ 005523 NOD-Tg(Ins2*Y16A)3Ell/GseJ 003499 NOD-Tg(Ins2-Fasl)24Ach 004346 NOD.Cg-Prkdcscid Tg(Ins2-CD80)3B7Flv/DvsJ 004230 NOD.Cg-Prkdcscid Tg(Ins2-E3)1Dvs/DvsJ 003843 NOD.Cg-Prkdcscid Tg(Ins2-GAD2)1Lt/LtJ 003844 NOD.Cg-Prkdcscid Tg(Ins2-GAD2)2Lt/LtJ 007840 NOD.Cg-Prkdcscid Tg(Ins2-CD86)12B70Flv/FswJ 005524 NOD.Cg-Tg(Ins2*Y16A)1Ell Ins1tm1Jja Ins2tm1Jja/GseJ 005525 NOD.Cg-Tg(Ins2*Y16A)3Ell Ins1tm1Jja Ins2tm1Jja/GseJ 006254 NOD.Cg-Tg(Ins2-Ccl21b)2Cys/JbsJ 006154 NOD.Cg-Tg(Ins2-Cxcl13)1Cys/JbsJ 003869 NOD.Cg-Tg(Ins2-E3)1Dvs/DvsJ 005685 NOD.Cg-Tg(Ins2-HA)165Bri/ShrmJ 002380 NOD.Cg-Tg(Ins2-TAg)1Lt Prkdcscid/DvsJ 004602 NOD.Cg-Tg(Ins2-rtTA)2Doi/DoiJ 004937 NOD.Cg-Tg(Ins2-tTA)1Doi/DoiJ 005734 NOD/Lt-Tg(Ins2-rtTA)1Ach/AchJ 005870 NOD/ShiLt(Cg)-Tg(Ins2-GAD2)2Lt/J 006777 NOD/ShiLt-Tg(Ins2-Cd274)2Mdos/MdosJ 005733 NOD/ShiLt-Tg(Ins2-Fas*I246N)1Ach/AchJ 003074 NOD/ShiLt-Tg(Ins2-GAD2)1Lt/LtJ 002033 NOD/ShiLt-Tg(Ins2-TAg)1Lt/J 004986 NOD/ShiLt-Tg(Ins2-cre)3Lt/LtJ 003855 NOD/ShiLt-Tg(Ins2-cre)5Lt/LtJ 004987 NOD/ShiLt-Tg(Ins2-cre)6Lt/LtJ 004226 NOD/ShiLtDvs-Tg(Ins2-E3*309)5Dvs/DvsJ 004227 NOD/ShiLtDvs-Tg(Ins2-E3*704)2Dvs/DvsJ 004968 NOD/ShiLtDvs-Tg(Ins2-E3*734)3Dvs/DvsJ 004990 NOD/ShiLtDvs-Tg(Ins2-E3*734)4Dvs/DvsJ 005714 NOR.Cg-Tg(Ins2-CD80)3B7Flv/LwnJ 008122 STOCK Tg(Ins2-cre/ERT)1Dam/J 008755 STOCK Tg(Ins2-rtTA)2Efr Tg(teto-DTA)1Gfi/J 008250 STOCK Tg(Ins2-rtTA)2Efr/J View Strains carrying other alleles of Ins2 (46 strains)
Strains carrying other alleles of Tg(Ins2-CD80)3B7Flv
005713 C.Cg-Tg(Ins2-CD80)3B7Flv/LwnJ 004346 NOD.Cg-Prkdcscid Tg(Ins2-CD80)3B7Flv/DvsJ 005714 NOR.Cg-Tg(Ins2-CD80)3B7Flv/LwnJ View Strains carrying other alleles of Tg(Ins2-CD80)3B7Flv (3 strains)
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View Related Disease (OMIM) Terms
View Mammalian Phenotype Terms
Mammalian Phenotype Terms provided by MGI
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Tg(Ins2-CD80)3B7Flv/?
involves: C57BL/6 * CBA/Ca * NOD/Caj
- endocrine/exocrine gland phenotype
- insulitis
- H2g7 homozygous transgenic mice show islet disruption with lymphocytic (T and B cell) infiltration, similar to diabetic NOD controls (MGI Ref ID J:26618)
- N2 mice after a subsequent backcross to NOD show islet disruption with lymphocytic infiltration as early as 4 weeks while non-transgenic H2g7 homozygous or heterozygous littermates show varying degrees of insulitis by ~6 weeks (MGI Ref ID J:26618)
- immune system phenotype
- increased susceptibility to autoimmune diabetes
- 2/17 transgenic mice from the first cross to NOD develop diabetes between 10 and 14 weeks, compared to no diabetes in (NOD x C57BL/6)F1 non-transgenic controls (MGI Ref ID J:26618)
- after a further backcross to NOD, diabetes onset is accelerated relative to transgenic mice from the initial cross to NOD with some developing diabetes at 4 weeks; by 12 weeks, 46.2% of transgenic mice homozygous for H2g7 develop diabetes compared to no non-transgenic H2g7 homozygous littermates, or NOD controls which only start to exhibit diabetes at 12 weeks (MGI Ref ID J:26618)
- insulitis
- H2g7 homozygous transgenic mice show islet disruption with lymphocytic (T and B cell) infiltration, similar to diabetic NOD controls (MGI Ref ID J:26618)
- N2 mice after a subsequent backcross to NOD show islet disruption with lymphocytic infiltration as early as 4 weeks while non-transgenic H2g7 homozygous or heterozygous littermates show varying degrees of insulitis by ~6 weeks (MGI Ref ID J:26618)
- renal/urinary system phenotype
- increased urine glucose level (MGI Ref ID J:26618)
- homeostasis/metabolism phenotype
- increased circulating glucose level
- transgenic mice exhibit blood glucose in excess of 13.9 mmol (250 mg/dl) (MGI Ref ID J:26618)
- increased urine glucose level (MGI Ref ID J:26618)
View Research Applications
Research Applications
This mouse can be used to support research in many areas including:
H2g7 relatedDiabetes and Obesity Research
Type 1 Diabetes (IDDM) Analysis Strains
NOD Transgenics
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Research Tools
Diabetes and Obesity Research
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
| Allele Symbol | H2g7 | ||
|---|---|---|---|
| Allele Name | g7 variant | ||
| Allele Type | Not Applicable | ||
| Gene Symbol and Name | H2, histocompatibility-2, MHC | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | H-2; MHC-II; | ||
| General Note | The g7 variant has been observed in the following strains: DBR7, NON.NOD-H2g7 | ||
| Allele Symbol | Tg(Ins2-CD80)3B7Flv | ||
| Allele Name | transgene insertion 3B7, Richard Flavell | ||
| Allele Type | Transgenic (random, expressed) | ||
| Common Name(s) | RIP-B7; RIP-B7-1; RIP-B7.1; RIP-CD80; | ||
| Mutation Made By | Richard Flavell, Yale University School of Medicine | ||
| Strain of Origin | (C57BL/6 x CBA/Ca)F2 | ||
| Expressed Gene | CD80, CD80 molecule, human | ||
| Promoter | Ins2, insulin 2, rat | ||
| General Note | Mice carrying this transgene that also are homozygous for Prkdcscid are characterized by pancreatic beta cells that express a rat insulin II promoter regulated transgene encoding the human CD80 T cell co-stimulatory molecule. | ||
| Molecular Note | The transgene contains a human CD80 antigen gene driven by the rat insulin II promoter (Ins2). [MGI Ref ID J:88250] | ||
Genotyping Protocols
Tg(Ins2-CD80)3B7Flv, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
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H2g7 relatedTg(Ins2-CD80)3B7Flv relatedBelizaire R; Unanue ER. 2009. Targeting proteins to distinct subcellular compartments reveals unique requirements for MHC class I and II presentation. Proc Natl Acad Sci U S A 106(41):17463-8. [PubMed: 19805168] [MGI Ref ID J:153672]
Binstadt BA; Hebert JL; Ortiz-Lopez A; Bronson R; Benoist C; Mathis D. 2009. The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms. Proc Natl Acad Sci U S A 106(39):16758-63. [PubMed: 19805369] [MGI Ref ID J:153217]
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Choisy-Rossi CM; Holl TM; Pierce MA; Chapman HD; Serreze DV. 2004. Enhanced pathogenicity of diabetogenic T cells escaping a non-MHC gene-controlled near death experience. J Immunol 173(6):3791-800. [PubMed: 15356126] [MGI Ref ID J:167508]
Driver JP; Chen YG; Zhang W; Asrat S; Serreze DV. 2011. Unmasking genes in a type 1 diabetes-resistant mouse strain that enhances pathogenic CD8 T-cell responses. Diabetes 60(4):1354-9. [PubMed: 21307079] [MGI Ref ID J:171763]
Driver JP; Scheuplein F; Chen YG; Grier AE; Wilson SB; Serreze DV. 2010. Invariant natural killer T-cell control of type 1 diabetes: a dendritic cell genetic decision of a silver bullet or Russian roulette. Diabetes 59(2):423-32. [PubMed: 19903740] [MGI Ref ID J:164162]
Ferreira C; Singh Y; Furmanski AL; Wong FS; Garden OA; Dyson J. 2009. Non-obese diabetic mice select a low-diversity repertoire of natural regulatory T cells. Proc Natl Acad Sci U S A 106(20):8320-5. [PubMed: 19359477] [MGI Ref ID J:148537]
Fossati G; Cooke A; Papafio RQ; Haskins K; Stockinger B. 1999. Triggering a second T cell receptor on diabetogenic T cells can prevent induction of diabetes. J Exp Med 190(4):577-83. [PubMed: 10449528] [MGI Ref ID J:108724]
Gray D; Abramson J; Benoist C; Mathis D. 2007. Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J Exp Med 204(11):2521-8. [PubMed: 17908938] [MGI Ref ID J:126040]
Jasinski JM; Yu L; Nakayama M; Li MM; Lipes MA; Eisenbarth GS; Liu E. 2006. Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout. Diabetes 55(7):1978-84. [PubMed: 16804066] [MGI Ref ID J:111874]
Klein J; Figueroa F; David CS. 1983. H-2 haplotypes, genes and antigens: second listing. II. The H-2 complex. Immunogenetics 17(6):553-96. [PubMed: 6407984] [MGI Ref ID J:7097]
Kouskoff V; Korganow AS; Duchatelle V; Degott C; Benoist C; Mathis D. 1996. Organ-specific disease provoked by systemic autoimmunity. Cell 87(5):811-22. [PubMed: 8945509] [MGI Ref ID J:36815]
Lee MS; Mueller R; Wicker LS; Peterson LB; Sarvetnick N. 1996. IL-10 is necessary and sufficient for autoimmune diabetes in conjunction with NOD MHC homozygosity. J Exp Med 183(6):2663-8. [PubMed: 8676087] [MGI Ref ID J:153576]
Leiter EH. 1998. NOD Mice and Related Strains: Origins, Husbandry and Biology Introduction. In: NOD Mice and Related Strains: Research Applications in Diabetes, AIDS, Cancer, and Other Diseases. RG Landes, Austin. [MGI Ref ID J:110093]
Levisetti MG; Lewis DM; Suri A; Unanue ER. 2008. Weak proinsulin peptide-major histocompatibility complexes are targeted in autoimmune diabetes in mice. Diabetes 57(7):1852-60. [PubMed: 18398138] [MGI Ref ID J:138230]
Luhder F; Katz J; Benoist C; Mathis D. 1998. Major histocompatibility complex class II molecules can protect from diabetes by positively selecting T cells with additional specificities. J Exp Med 187(3):379-87. [PubMed: 9449718] [MGI Ref ID J:108722]
Ma YD; Park C; Zhao H; Oduro KA Jr; Tu X; Long F; Allen PM; Teitelbaum SL; Choi K. 2009. Defects in osteoblast function but no changes in long-term repopulating potential of hematopoietic stem cells in a mouse chronic inflammatory arthritis model. Blood 114(20):4402-10. [PubMed: 19759358] [MGI Ref ID J:154922]
Mahler M; Bristol IJ; Leiter EH; Workman AE; Birkenmeier EH; Elson CO; Sundberg JP. 1998. Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis. Am J Physiol 274(3 Pt 1):G544-51. [PubMed: 9530156] [MGI Ref ID J:46553]
Mangada J; Pearson T; Brehm MA; Wicker LS; Peterson LB; Shultz LD; Serreze DV; Rossini AA; Greiner DL. 2009. Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice. Diabetes 58(1):165-73. [PubMed: 18984741] [MGI Ref ID J:146982]
Martin-Orozco N; Chen Z; Poirot L; Hyatt E; Chen A; Kanagawa O; Sharpe A; Mathis D; Benoist C. 2003. Paradoxical dampening of anti-islet self-reactivity but promotion of diabetes by OX40 ligand. J Immunol 171(12):6954-60. [PubMed: 14662903] [MGI Ref ID J:86926]
Pearson T; Markees TG; Serreze DV; Pierce MA; Marron MP; Wicker LS; Peterson LB; Shultz LD; Mordes JP; Rossini AA; Greiner DL. 2003. Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice. J Immunol 171(1):185-95. [PubMed: 12816997] [MGI Ref ID J:109845]
Podolin PL; Pressey A; DeLarato NH; Fischer PA; Peterson LB; Wicker LS. 1993. I-E+ nonobese diabetic mice develop insulitis and diabetes. J Exp Med 178(3):793-803. [PubMed: 8350054] [MGI Ref ID J:14178]
Serreze DV; Gallichan WS; Snider DP; Croitoru K; Rosenthal KL; Leiter EH; Christianson GJ; Dudley ME; Roopenian DC. 1996. MHC class I-mediated antigen presentation and induction of CD8+ cytotoxic T-cell responses in autoimmune diabetes-prone NOD mice. Diabetes 45(7):902-8. [PubMed: 8666141] [MGI Ref ID J:33688]
Suwanai H; Wilcox MA; Mathis D; Benoist C. 2010. A defective Il15 allele underlies the deficiency in natural killer cell activity in nonobese diabetic mice. Proc Natl Acad Sci U S A 107(20):9305-10. [PubMed: 20439722] [MGI Ref ID J:160284]
Turley SJ; Lee JW; Dutton-Swain N; Mathis D; Benoist C. 2005. Endocrine self and gut non-self intersect in the pancreatic lymph nodes. Proc Natl Acad Sci U S A 102(49):17729-33. [PubMed: 16317068] [MGI Ref ID J:104385]
Victoratos P; Kollias G. 2009. Induction of autoantibody-mediated spontaneous arthritis critically depends on follicular dendritic cells. Immunity 30(1):130-42. [PubMed: 19119026] [MGI Ref ID J:143728]
Yoshida T; Jiang F; Honjo T; Okazaki T. 2008. PD-1 deficiency reveals various tissue-specific autoimmunity by H-2b and dose-dependent requirement of H-2g7 for diabetes in NOD mice. Proc Natl Acad Sci U S A 105(9):3533-8. [PubMed: 18299579] [MGI Ref ID J:132764]
Zhang C; Todorov I; Lin CL; Atkinson M; Kandeel F; Forman S; Zeng D. 2007. Elimination of insulitis and augmentation of islet beta cell regeneration via induction of chimerism in overtly diabetic NOD mice. Proc Natl Acad Sci U S A 104(7):2337-42. [PubMed: 17267595] [MGI Ref ID J:119749]
Brosi H; Reiser M; Rajasalu T; Spyrantis A; Oswald F; Boehm BO; Schirmbeck R. 2009. Processing in the endoplasmic reticulum generates an epitope on the insulin A chain that stimulates diabetogenic CD8 T cell responses. J Immunol 183(11):7187-95. [PubMed: 19890053] [MGI Ref ID J:157398]
Devendra D; Jasinski J; Melanitou E; Nakayama M; Li M; Hensley B; Paronen J; Moriyama H; Miao D; Eisenbarth GS; Liu E. 2005. Interferon-alpha as a mediator of polyinosinic:polycytidylic acid-induced type 1 diabetes. Diabetes 54(9):2549-56. [PubMed: 16123342] [MGI Ref ID J:129147]
Devendra D; Paronen J; Moriyama H; Miao D; Eisenbarth GS; Liu E. 2004. Differential immune response to B:9-23 insulin 1 and insulin 2 peptides in animal models of type 1 diabetes. J Autoimmun 23(1):17-26. [PubMed: 15236749] [MGI Ref ID J:91669]
Guerder S; Eynon EE; Flavell RA. 1998. Autoimmunity without diabetes in transgenic mice expressing beta cell-specific CD86, but not CD80: parameters that trigger progression to diabetes. J Immunol 161(5):2128-40. [PubMed: 9725204] [MGI Ref ID J:93555]
Guerder S; Picarella DE; Linsley PS; Flavell RA. 1994. Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice. Proc Natl Acad Sci U S A 91(11):5138-42. [PubMed: 7515187] [MGI Ref ID J:88250]
Havari E; Lennon-Dumenil AM; Klein L; Neely D; Taylor JA; McInerney MF; Wucherpfennig KW; Lipes MA. 2004. Expression of the B7.1 costimulatory molecule on pancreatic beta cells abrogates the requirement for CD4 T cells in the development of type 1 diabetes. J Immunol 173(2):787-96. [PubMed: 15240665] [MGI Ref ID J:91915]
Marron MP; Graser RT; Chapman HD; Serreze DV. 2002. Functional evidence for the mediation of diabetogenic T cell responses by HLA-A2.1 MHC class I molecules through transgenic expression in NOD mice. Proc Natl Acad Sci U S A 99(21):13753-8. [PubMed: 12361980] [MGI Ref ID J:109851]
Rajagopalan G; Kudva YC; Chen L; Wen L; David CS. 2003. Autoimmune diabetes in HLA-DR3/DQ8 transgenic mice expressing the co-stimulatory molecule B7-1 in the beta cells of islets of Langerhans. Int Immunol 15(9):1035-44. [PubMed: 12917255] [MGI Ref ID J:85223]
Rajasalu T; Brosi H; Schuster C; Spyrantis A; Boehm BO; Chen L; Reimann J; Schirmbeck R. 2010. Deficiency in B7-H1 (PD-L1)/PD-1 coinhibition triggers pancreatic beta-cell destruction by insulin-specific, murine CD8 T-cells. Diabetes 59(8):1966-73. [PubMed: 20484136] [MGI Ref ID J:169352]
Serra P; Amrani A; Yamanouchi J; Han B; Thiessen S; Utsugi T; Verdaguer J; Santamaria P. 2003. CD40 ligation releases immature dendritic cells from the control of regulatory CD4+CD25+ T cells. Immunity 19(6):877-89. [PubMed: 14670304] [MGI Ref ID J:86995]
Skak K; Haase C; Michelsen BK. 2005. Preservation of beta-cell function during immune-mediated, B7-1-dependent alpha-cell destruction. Eur J Immunol 35(9):2583-90. [PubMed: 16078275] [MGI Ref ID J:113486]
Stephens LA; Kay TW. 1995. Pancreatic expression of B7 co-stimulatory molecules in the non-obese diabetic mouse. Int Immunol 7(12):1885-95. [PubMed: 8746558] [MGI Ref ID J:30235]
Thomas IJ; Petrich de Marquesini LG; Ravanan R; Smith RM; Guerder S; Flavell RA; Wraith DC; Wen L; Wong FS. 2007. CD86 has sustained costimulatory effects on CD8 T cells. J Immunol 179(9):5936-46. [PubMed: 17947667] [MGI Ref ID J:138692]
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Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, RG10/RG30.
| Pricing for USA, Canada and Mexico shipping destinations |
|
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Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $1980.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
- Cryorecovery - Standard.
We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
|
![]() |
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2574.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
- Cryorecovery - Standard.
We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
|
|
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
| Control | ||
|---|---|---|
| 003300 B6.NOD-(D17Mit21-D17Mit10)/LtJ | (approximate) | |
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
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In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
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Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.