JAX Mice Database - 005717 B6(NOD) H2<g7>-Sostdc1<shk>/J

Strain Name:	B6(NOD) H2^g7-Sostdc1^shk/J
Stock Number:	005717
Availability:	Repository- Live

Description
Phenotype
Genes & alleles
Genotyping
Health & husbandry
References
Purchasing information
Terms of Use

Description

Strain Information

Type Major Histocompatibility Congenic; Mutant Strain; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.

Visit our online Nomenclature tutorial.

Mating System Homozygote x Heterozygote (Female x Male) 28-NOV-07

Mating System Heterozygote x Homozygote (Female x Male) 28-NOV-07

Species laboratory mouse

Generation F11 (06-NOV-09)

Description
Mice homozygous for the sharkey mutation on this predominantly C57BL/6J background have both upper and lower supernumerary incisors with separate roots for the extra teeth. When outcrossed to CAST/EiJ the F2 only have upper supernumerary incisors.
Development
The sharkey (shk) mutation arose spontaneously in a C57BL/6J congenic strain homozygous for the NOD derived H2^g7 and carrying a transgene. This transgene has been bred out of this strain, but the strain remains homozygous for H2^g7. This mutant subline has been maintained by sibling intercrossing sharkey phenotypic homozygotes and unaffected heterozygotes. In 2007 this strain reached generation F8.

Control Information

	Control
	Heterozygote

Considerations for Choosing Controls

Related Strains

Strains carrying H2^g7 allele

003851 ALR.NOD-(D17Mit30-D17Mit123)/Lt

010972 B10.NOD-(rs13459152-rs13483054)/1107MrkJ

005715 B6.Cg H2^g7-Tg(Ins2-CD80)3B7Flv/LwnJ

003068 B6.NOD-(Csf2-D11Mit42) (D17Mit21-D17Mit10)/J

003300 B6.NOD-(D17Mit21-D17Mit10)/LtJ

003069 B6.NOD-(D1Mit3-Bcl2) (D17Mit21-D17Mit10)/LtJ

003071 B6.NOD-(D1Mit5.1-D1Mit15) (D17Mit21-D17Mit10)/J

003067 B6.NOD-(D3Mit132-Tshb) (D17Mit21-D17Mit10)/J

003066 B6.NOD-(D6Mit54-D6Mit14) (D17Mit21-D17Mit10)/J

001627 NON.NOD-H2^g7/LtJ

View Strains carrying H2^g7 (10 strains)

Strains carrying other alleles of H2

006500 129.NOD-(D17Mit175-H2)/J

001649 A.BY H2^bc H2-T18^f/SnJ-Dstn^corn1/J

000140 A.BY-H2^bc H2-T18^f/SnJ

000472 A.CA-H2^f H2-T18^a/SnJ

000471 A.SW-H2^s H2-T18^b/SnJ

001066 A.TH-H2^t2/SfDvEgMobJ

001067 A.TL-H2^t1/SfDvEgMobJ

002089 AK.B6-H2^b Fv1^b/J

002090 AK.B6-H2^b/J

001094 AK.L-H2^b/1CyTyJ

001095 AK.L-H2^oz2/CyJ

001096 AK.L-H2^oz3/CyJ

000470 AK.M-H2^m H2-T18^a/nSnJ

000469 B10.A-H2^a H2-T18^a/SgSnJ

000468 B10.A-H2^h2/(2R)SgSnJ

001150 B10.A-H2^h4/(4R)SgDvEgJ

001149 B10.A-H2ⁱ³/(3R)SgDvEgJ

000467 B10.A-H2ⁱ⁵ H2-T18^a/(5R)SgSnJ

000466 B10.AKM-H2^m H2-T18^a/SnJ

001954 B10.AQR-H2^y1/KljMcdJ

000465 B10.BR-H2^k H2-T18^a/SgSnJ

004804 B10.BR-H2^k H2-T18^a/SgSnJJrep

006446 B10.Cg H2^h4-Sh3pxd2b^nee/GrsrJ

005308 B10.Cg-H2^d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ

005534 B10.Cg-H2^d Tg(Ins2-HA)165Bri/ShrmJ

010514 B10.Cg-H2^g Tg(Cd4-Klra1)6295Dl/J

006100 B10.Cg-H2^k Tg(NFkB/Fos-luc)26Rinc/J

006102 B10.Cg-H2^k Tg(Il2/NFAT-luc)83Rinc/J

005895 B10.Cg-Thy1^a H2^d Tg(TcraCl1,TcrbCl1)1Shrm/J

002024 B10.D1-H2^q/SgJ

001163 B10.D2-H2^bm23/EgJ

000462 B10.D2-H2^d/n2SnJ

001164 B10.D2-H2^dm1/EgJ

001151 B10.D2-H2^g3/(103R)EgJ

001153 B10.D2-H2ⁱ⁷/(107R)EgJ

001152 B10.D2-H2^ia/(106R)EgJ

000460 B10.D2-Hc⁰ H2^d H2-T18^c/o2SnJ

000461 B10.D2-Hc⁰ H2^d H2-T18^c/oSnJ

000463 B10.D2-Hc¹ H2^d H2-T18^c/nSnJ

003147 B10.D2-Hc¹ H2^d H2-T18^c/nSnJ-Tg(DO11.10)10Dlo/J

000464 B10.DA-H2^qp1 H2-T18^b/(80NS)SnJ

001823 B10.F-H2^bp5/(14R)J

001818 B10.F-H2^pb1/(13R)J

001012 B10.HTG-H2^g/2CyJ

000999 B10.HTG-H2^g/3CyJ

001894 B10.LG-H2^ar1/J

000459 B10.M-H2^f H2-T18^a^?/SnJ

002225 B10.M-H2^f/nMob Fmn1^ld-2J/J

001068 B10.M-H2^f/nMobJ

000739 B10.M-H2^fm2/MobJ

001154 B10.MBR-H2^bq1/SxEgJ

001825 B10.P-H2^kp1/(10R)SgJ

003199 B10.PL-H2^u H2-T18^a/(73NS)Sn-Tg(TCRA)B1Jg/J

003200 B10.PL-H2^u H2-T18^a/(73NS)Sn-Tg(TCRB)C14Jg/J

000458 B10.PL-H2^u H2-T18^a/(73NS)SnJ

003599 B10.RIII H2^r H2-T18^b/(71NS)Sn-Ap3b1^pe-11J/J

000457 B10.RIII-H2^r H2-T18^b/(71NS)SnJ

001069 B10.RIII-H2^r/(71NS)nMobJ

001760 B10.S-H2^as1/(8R)/J

001953 B10.S-H2^s/SgMcdJ

001817 B10.S-H2^sm1/(12R)SgJ

001650 B10.S-H2^t4/(9R)/J

000456 B10.SM H2^v H2-T18^b/(70NS)Sn-cw/J

001155 B10.T-H2^y2/(6R)SgDvEgJ

000445 B10.WB-H2^j H2-T18^b/SnJ

000444 B10.Y-H2^pa H2-T18^c/SnJ

003483 B6 x B10.D1-H2^q/SgJ-Nox3^het-2J/J

003561 B6 x B10.PL-H2^u/(73NS)Sn-Hxl/J

002995 B6 x C.B10-H2^b/LiMcdJ-Fbn2^fp-2J/J

003584 B6.129S2-H2^dlAb1-Ea/J

001148 B6.AK-H2^k/FlaEgJ

001895 B6.AK-H2^k/J

001160 B6.C-H2^bm10/KhEgJ

001161 B6.C-H2^bm11/KhEgJ

000364 B6.C-H2^bm2/ByJ

000369 B6.C-H2^bm4/ByJ

001158 B6.C-H2^bm7/KhEgJ

000360 B6.C-H2^d Mdmg1^BALB/cBy/aByJ

000359 B6.C-H2^d/bByJ

001429 B6.C-H2^g6/J

007958 B6.Cg-H2^b3/FlaCmwJ

007959 B6.Cg-H2^b4/FlaCmwJ

000944 B6.SJL-H2^b C3^c/2CyJ

000966 B6.SJL-H2^s C3^c/1CyJ

000945 B6.SW/1CyJ

003374 B6;129S2-H2^dlAb1-Ea/J

003240 B6;B10.A-H2^a-Tg(H2KmPCC)2939Stoe/J

002844 BALB.5R-H2ⁱ⁵/LilJ

001165 BALB/c-H2^dm2/KhEgJ

001041 BKS.B6-H2^b/J

001892 BRVR.B10-H2^b/J

001893 BRVR.D2-H2^d/J

002845 C.B-H2^b Tg(H2-D^d)D8Gja/LilJ

001952 C.B10-H2^b/LilMcdJ

001951 C.C3-H2^k/LilMcdJ

000443 C3.HTG-H2^g H2-T18^b^?/SnJ

000441 C3.JK-H2^j H2-T18^b/SnJ

000440 C3.LG-H2^ar1/CkcCyJ

000439 C3.NB-H2^p H2-T18^c^?/SnJ

000438 C3.SW-H2^b/SnJ

000473 C3H-H2^o2 C4b^b/SfSnJ

001156 C57BL/6J-H2^bm3/EgJ

001157 C57BL/6Kh-H2^bm5/KhEgJ

000437 D1.C-H2^d H2-T18^c/SnJ

000436 D1.DA-H2^qp1/SnJ

000435 D1.LP-H2^b H2-T18^b^?/SnJ

000434 LP.RIII-H2^r H2-T18^b/SnJ

001383 LT.MA-Glo1^b H2^k/J

002591 NOD.B10Sn-H2^b/J

006935 NOD.Cg-H2^b thnh/J

004447 NOD.Cg-H2^h4/DilTacUmmJ

001626 NOD.NON-H2^nb1/LtJ

002032 NOD.SW-H2^q/J

002974 STOCK Es1^e H2^d/J

001308 STOCK H2^473a/J

003153 WLC.C-H2^d.GR-Mtv2/MorJ

003154 WLC.C-H2^d/MorJ

View Strains carrying other alleles of H2 (117 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
assigned by genotype

Sostdc1^shk/Sostdc1^shk
involves: C57BL/6J * NOD
craniofacial phenotype

abnormal hard palate (MGI Ref ID J:127012)

abnormal palatine shelf (MGI Ref ID J:127012)

asymetrical, disorganized formation

decreased skull height (MGI Ref ID J:127012)

females, but not males, have shorter skull height

decreased skull width (MGI Ref ID J:127012)

males have less skull morphological abnormalities than females, but do have smaller skull width than controls

short mandible (MGI Ref ID J:127012)

females, but not males, have a shorter jaw length than wildtype controls

supernumerary incisors (MGI Ref ID J:127012)

there is some variation in the rate of growth of these supernumerary incisors

an extra pair of upper and lower incisors erupt posterior to the normal incisors, and there are separate roots for these extra teeth

skeleton phenotype

abnormal palatine shelf (MGI Ref ID J:127012)

asymetrical, disorganized formation

decreased skull height (MGI Ref ID J:127012)

females, but not males, have shorter skull height

decreased skull width (MGI Ref ID J:127012)

males have less skull morphological abnormalities than females, but do have smaller skull width than controls

short mandible (MGI Ref ID J:127012)

females, but not males, have a shorter jaw length than wildtype controls

digestive/alimentary phenotype

abnormal hard palate (MGI Ref ID J:127012)

abnormal palatine shelf (MGI Ref ID J:127012)

asymetrical, disorganized formation

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.
Sostdc1^shk/Sostdc1^shk
involves: C57BL/6J * CAST/EiJ * NOD
craniofacial phenotype

supernumerary incisors (MGI Ref ID J:127012)

F2 homozygotes from a cross to CAST/EiJ have upper, but not lower, supernumerary incisors

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:
H2^g7 related

Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers

Sostdc1^shk related

Developmental Biology Research
Craniofacial and Palate Defects
Skeletal Defects

Genes & Alleles

Gene & Allele Information


Allele Symbol		H2^g7
Allele Name		g7 variant
Allele Type		Not Applicable
Gene Symbol and Name		H2, histocompatibility-2, MHC
Chromosome		17
Gene Common Name(s)		H-2; MHC-II;
General Note		The g7 variant has been observed in the following strains: DBR7, NON.NOD-H2^g7

Allele Symbol		Sostdc1^shk
Allele Name		sharkey
Allele Type		Spontaneous
Strain of Origin		B6.NOD-H2
Gene Symbol and Name		Sostdc1, sclerostin domain containing 1
Chromosome		12
Gene Common Name(s)		0610006G05Rik; CDA019; DKFZp564D206; ECTODIN; RIKEN cDNA 0610006G05 gene; Sostl; USAG-1; USAG1; Wise; sclerostin-like;

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Genotyping resources and troubleshooting

References

Selected Reference(s)

Giggey J; Curtain MM; Donahue LR. 2007. Sharkey, a new mutation in the Sostdc1 gene MGI Direct Data Submission :. [MGI Ref ID J:127012]

Additional References

H2^g7 related

Belizaire R; Unanue ER. 2009. Targeting proteins to distinct subcellular compartments reveals unique requirements for MHC class I and II presentation. Proc Natl Acad Sci U S A 106(41):17463-8. [PubMed: 19805168] [MGI Ref ID J:153672]

Binstadt BA; Hebert JL; Ortiz-Lopez A; Bronson R; Benoist C; Mathis D. 2009. The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms. Proc Natl Acad Sci U S A 106(39):16758-63. [PubMed: 19805369] [MGI Ref ID J:153217]

Carrasco-Marin E; Shimizu J; Kanagawa O; Unanue ER. 1996. The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders. J Immunol 156(2):450-8. [PubMed: 8543793] [MGI Ref ID J:30538]

Ferreira C; Singh Y; Furmanski AL; Wong FS; Garden OA; Dyson J. 2009. Non-obese diabetic mice select a low-diversity repertoire of natural regulatory T cells. Proc Natl Acad Sci U S A 106(20):8320-5. [PubMed: 19359477] [MGI Ref ID J:148537]

Fossati G; Cooke A; Papafio RQ; Haskins K; Stockinger B. 1999. Triggering a second T cell receptor on diabetogenic T cells can prevent induction of diabetes. J Exp Med 190(4):577-83. [PubMed: 10449528] [MGI Ref ID J:108724]

Gray D; Abramson J; Benoist C; Mathis D. 2007. Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J Exp Med 204(11):2521-8. [PubMed: 17908938] [MGI Ref ID J:126040]

Jasinski JM; Yu L; Nakayama M; Li MM; Lipes MA; Eisenbarth GS; Liu E. 2006. Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout. Diabetes 55(7):1978-84. [PubMed: 16804066] [MGI Ref ID J:111874]

Klein J; Figueroa F; David CS. 1983. H-2 haplotypes, genes and antigens: second listing. II. The H-2 complex. Immunogenetics 17(6):553-96. [PubMed: 6407984] [MGI Ref ID J:7097]

Kouskoff V; Korganow AS; Duchatelle V; Degott C; Benoist C; Mathis D. 1996. Organ-specific disease provoked by systemic autoimmunity. Cell 87(5):811-22. [PubMed: 8945509] [MGI Ref ID J:36815]

Lee MS; Mueller R; Wicker LS; Peterson LB; Sarvetnick N. 1996. IL-10 is necessary and sufficient for autoimmune diabetes in conjunction with NOD MHC homozygosity. J Exp Med 183(6):2663-8. [PubMed: 8676087] [MGI Ref ID J:153576]

Leiter EH. 1998. NOD Mice and Related Strains: Origins, Husbandry and Biology Introduction. In: NOD Mice and Related Strains: Research Applications in Diabetes, AIDS, Cancer, and Other Diseases. RG Landes, Austin. [MGI Ref ID J:110093]

Levisetti MG; Lewis DM; Suri A; Unanue ER. 2008. Weak proinsulin peptide-major histocompatibility complexes are targeted in autoimmune diabetes in mice. Diabetes 57(7):1852-60. [PubMed: 18398138] [MGI Ref ID J:138230]

Luhder F; Katz J; Benoist C; Mathis D. 1998. Major histocompatibility complex class II molecules can protect from diabetes by positively selecting T cells with additional specificities. J Exp Med 187(3):379-87. [PubMed: 9449718] [MGI Ref ID J:108722]

Mahler M; Bristol IJ; Leiter EH; Workman AE; Birkenmeier EH; Elson CO; Sundberg JP. 1998. Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis. Am J Physiol 274(3 Pt 1):G544-51. [PubMed: 9530156] [MGI Ref ID J:46553]

Mangada J; Pearson T; Brehm MA; Wicker LS; Peterson LB; Shultz LD; Serreze DV; Rossini AA; Greiner DL. 2009. Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice. Diabetes 58(1):165-73. [PubMed: 18984741] [MGI Ref ID J:146982]

Martin-Orozco N; Chen Z; Poirot L; Hyatt E; Chen A; Kanagawa O; Sharpe A; Mathis D; Benoist C. 2003. Paradoxical dampening of anti-islet self-reactivity but promotion of diabetes by OX40 ligand. J Immunol 171(12):6954-60. [PubMed: 14662903] [MGI Ref ID J:86926]

Pearson T; Markees TG; Serreze DV; Pierce MA; Marron MP; Wicker LS; Peterson LB; Shultz LD; Mordes JP; Rossini AA; Greiner DL. 2003. Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice. J Immunol 171(1):185-95. [PubMed: 12816997] [MGI Ref ID J:109845]

Podolin PL; Pressey A; DeLarato NH; Fischer PA; Peterson LB; Wicker LS. 1993. I-E+ nonobese diabetic mice develop insulitis and diabetes. J Exp Med 178(3):793-803. [PubMed: 8350054] [MGI Ref ID J:14178]

Serreze DV; Gallichan WS; Snider DP; Croitoru K; Rosenthal KL; Leiter EH; Christianson GJ; Dudley ME; Roopenian DC. 1996. MHC class I-mediated antigen presentation and induction of CD8+ cytotoxic T-cell responses in autoimmune diabetes-prone NOD mice. Diabetes 45(7):902-8. [PubMed: 8666141] [MGI Ref ID J:33688]

Turley SJ; Lee JW; Dutton-Swain N; Mathis D; Benoist C. 2005. Endocrine self and gut non-self intersect in the pancreatic lymph nodes. Proc Natl Acad Sci U S A 102(49):17729-33. [PubMed: 16317068] [MGI Ref ID J:104385]

Victoratos P; Kollias G. 2009. Induction of autoantibody-mediated spontaneous arthritis critically depends on follicular dendritic cells. Immunity 30(1):130-42. [PubMed: 19119026] [MGI Ref ID J:143728]

Wong FS; Du W; Thomas IJ; Wen L. 2005. The influence of the major histocompatibility complex on development of autoimmune diabetes in RIP-B7.1 mice. Diabetes 54(7):2032-40. [PubMed: 15983204] [MGI Ref ID J:109830]

Yoshida T; Jiang F; Honjo T; Okazaki T. 2008. PD-1 deficiency reveals various tissue-specific autoimmunity by H-2b and dose-dependent requirement of H-2g7 for diabetes in NOD mice. Proc Natl Acad Sci U S A 105(9):3533-8. [PubMed: 18299579] [MGI Ref ID J:132764]

Zhang C; Todorov I; Lin CL; Atkinson M; Kandeel F; Forman S; Zeng D. 2007. Elimination of insulitis and augmentation of islet beta cell regeneration via induction of chimerism in overtly diabetic NOD mice. Proc Natl Acad Sci U S A 104(7):2337-42. [PubMed: 17267595] [MGI Ref ID J:119749]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports
Room Number A1

Colony Maintenance

Breeding & Husbandry Homozygotes must have their teeth trimmed and attention must be paid to their ability to eat. The rate of supernumery tooth growth varies within the strain, with the most affected homozygotes requiring tooth trimming approximately once per week. In addition to standard food pellets, ground food should be supplied in the cage.

Mating System Homozygote x Heterozygote (Female x Male) 28-NOV-07

Heterozygote x Homozygote (Female x Male) 28-NOV-07

Breeding & Husbandry	Homozygotes must have their teeth trimmed and attention must be paid to their ability to eat. The rate of supernumery tooth growth varies within the strain, with the most affected homozygotes requiring tooth trimming approximately once per week. In addition to standard food pellets, ground food should be supplied in the cage.
Mating System	Homozygote x Heterozygote (Female x Male) 28-NOV-07
	Heterozygote x Homozygote (Female x Male) 28-NOV-07

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations

Weeks of Age Price (US dollars $) Gender Genotypes Provided

Individual Mouse $127.80 Female or Male Homozygous for H2^g7, Heterozygous for Sostdc1^shk

$207.10 Female or Male Homozygous for H2^g7, Homozygous for Sostdc1^shk

Pairs /Price (US dollars $) Pair Genotype

$255.60 Homozygous for H2^g7, Heterozygous for Sostdc1^shk x Homozygous for H2^g7, Heterozygous for Sostdc1^shk

$334.90 Homozygous for H2^g7, Heterozygous for Sostdc1^shk x Homozygous for H2^g7, Homozygous for Sostdc1^shk

$414.20 Homozygous for H2^g7, Homozygous for Sostdc1^shk x Homozygous for H2^g7, Homozygous for Sostdc1^shk

Weeks of Age	Price (US dollars $)	Gender	Genotypes Provided
Individual Mouse	$127.80	Female or Male	Homozygous for H2^g7, Heterozygous for Sostdc1^shk
	$207.10	Female or Male	Homozygous for H2^g7, Homozygous for Sostdc1^shk

Pairs /Price (US dollars $)	Pair Genotype
$255.60	Homozygous for H2^g7, Heterozygous for Sostdc1^shk x Homozygous for H2^g7, Heterozygous for Sostdc1^shk
$334.90	Homozygous for H2^g7, Heterozygous for Sostdc1^shk x Homozygous for H2^g7, Homozygous for Sostdc1^shk
$414.20	Homozygous for H2^g7, Homozygous for Sostdc1^shk x Homozygous for H2^g7, Homozygous for Sostdc1^shk

Additional Supply Details

Pricing for International shipping destinations

Weeks of Age Price (US dollars $) Gender Genotypes Provided

Individual Mouse $166.20 Female or Male Homozygous for H2^g7, Heterozygous for Sostdc1^shk

$269.30 Female or Male Homozygous for H2^g7, Homozygous for Sostdc1^shk

Pairs /Price (US dollars $) Pair Genotype

$332.30 Homozygous for H2^g7, Heterozygous for Sostdc1^shk x Homozygous for H2^g7, Heterozygous for Sostdc1^shk

$435.40 Homozygous for H2^g7, Heterozygous for Sostdc1^shk x Homozygous for H2^g7, Homozygous for Sostdc1^shk

$538.50 Homozygous for H2^g7, Homozygous for Sostdc1^shk x Homozygous for H2^g7, Homozygous for Sostdc1^shk

Weeks of Age	Price (US dollars $)	Gender	Genotypes Provided
Individual Mouse	$166.20	Female or Male	Homozygous for H2^g7, Heterozygous for Sostdc1^shk
	$269.30	Female or Male	Homozygous for H2^g7, Homozygous for Sostdc1^shk

Pairs /Price (US dollars $)	Pair Genotype
$332.30	Homozygous for H2^g7, Heterozygous for Sostdc1^shk x Homozygous for H2^g7, Heterozygous for Sostdc1^shk
$435.40	Homozygous for H2^g7, Heterozygous for Sostdc1^shk x Homozygous for H2^g7, Homozygous for Sostdc1^shk
$538.50	Homozygous for H2^g7, Homozygous for Sostdc1^shk x Homozygous for H2^g7, Homozygous for Sostdc1^shk

Additional Supply Details

Supply Details

Standard Supply	Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement.
Supply Notes	Usually shipped between four and eight weeks of age. Genomic DNA is available for this strain from the Mouse DNA Resource.

Standard Supply

Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement.

Supply Notes

Usually shipped between four and eight weeks of age.
Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	Heterozygote

Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.

003851	ALR.NOD-(D17Mit30-D17Mit123)/Lt
010972	B10.NOD-(rs13459152-rs13483054)/1107MrkJ
005715	B6.Cg H2^g7-Tg(Ins2-CD80)3B7Flv/LwnJ
003068	B6.NOD-(Csf2-D11Mit42) (D17Mit21-D17Mit10)/J
003300	B6.NOD-(D17Mit21-D17Mit10)/LtJ
003069	B6.NOD-(D1Mit3-Bcl2) (D17Mit21-D17Mit10)/LtJ
003071	B6.NOD-(D1Mit5.1-D1Mit15) (D17Mit21-D17Mit10)/J
003067	B6.NOD-(D3Mit132-Tshb) (D17Mit21-D17Mit10)/J
003066	B6.NOD-(D6Mit54-D6Mit14) (D17Mit21-D17Mit10)/J
001627	NON.NOD-H2^g7/LtJ

006500	129.NOD-(D17Mit175-H2)/J
001649	A.BY H2^bc H2-T18^f/SnJ-Dstn^corn1/J
000140	A.BY-H2^bc H2-T18^f/SnJ
000472	A.CA-H2^f H2-T18^a/SnJ
000471	A.SW-H2^s H2-T18^b/SnJ
001066	A.TH-H2^t2/SfDvEgMobJ
001067	A.TL-H2^t1/SfDvEgMobJ
002089	AK.B6-H2^b Fv1^b/J
002090	AK.B6-H2^b/J
001094	AK.L-H2^b/1CyTyJ
001095	AK.L-H2^oz2/CyJ
001096	AK.L-H2^oz3/CyJ
000470	AK.M-H2^m H2-T18^a/nSnJ
000469	B10.A-H2^a H2-T18^a/SgSnJ
000468	B10.A-H2^h2/(2R)SgSnJ
001150	B10.A-H2^h4/(4R)SgDvEgJ
001149	B10.A-H2ⁱ³/(3R)SgDvEgJ
000467	B10.A-H2ⁱ⁵ H2-T18^a/(5R)SgSnJ
000466	B10.AKM-H2^m H2-T18^a/SnJ
001954	B10.AQR-H2^y1/KljMcdJ
000465	B10.BR-H2^k H2-T18^a/SgSnJ
004804	B10.BR-H2^k H2-T18^a/SgSnJJrep
006446	B10.Cg H2^h4-Sh3pxd2b^nee/GrsrJ
005308	B10.Cg-H2^d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005534	B10.Cg-H2^d Tg(Ins2-HA)165Bri/ShrmJ
010514	B10.Cg-H2^g Tg(Cd4-Klra1)6295Dl/J
006100	B10.Cg-H2^k Tg(NFkB/Fos-luc)26Rinc/J
006102	B10.Cg-H2^k Tg(Il2/NFAT-luc)83Rinc/J
005895	B10.Cg-Thy1^a H2^d Tg(TcraCl1,TcrbCl1)1Shrm/J
002024	B10.D1-H2^q/SgJ
001163	B10.D2-H2^bm23/EgJ
000462	B10.D2-H2^d/n2SnJ
001164	B10.D2-H2^dm1/EgJ
001151	B10.D2-H2^g3/(103R)EgJ
001153	B10.D2-H2ⁱ⁷/(107R)EgJ
001152	B10.D2-H2^ia/(106R)EgJ
000460	B10.D2-Hc⁰ H2^d H2-T18^c/o2SnJ
000461	B10.D2-Hc⁰ H2^d H2-T18^c/oSnJ
000463	B10.D2-Hc¹ H2^d H2-T18^c/nSnJ
003147	B10.D2-Hc¹ H2^d H2-T18^c/nSnJ-Tg(DO11.10)10Dlo/J
000464	B10.DA-H2^qp1 H2-T18^b/(80NS)SnJ
001823	B10.F-H2^bp5/(14R)J
001818	B10.F-H2^pb1/(13R)J
001012	B10.HTG-H2^g/2CyJ
000999	B10.HTG-H2^g/3CyJ
001894	B10.LG-H2^ar1/J
000459	B10.M-H2^f H2-T18^a^?/SnJ
002225	B10.M-H2^f/nMob Fmn1^ld-2J/J
001068	B10.M-H2^f/nMobJ
000739	B10.M-H2^fm2/MobJ
001154	B10.MBR-H2^bq1/SxEgJ
001825	B10.P-H2^kp1/(10R)SgJ
003199	B10.PL-H2^u H2-T18^a/(73NS)Sn-Tg(TCRA)B1Jg/J
003200	B10.PL-H2^u H2-T18^a/(73NS)Sn-Tg(TCRB)C14Jg/J
000458	B10.PL-H2^u H2-T18^a/(73NS)SnJ
003599	B10.RIII H2^r H2-T18^b/(71NS)Sn-Ap3b1^pe-11J/J
000457	B10.RIII-H2^r H2-T18^b/(71NS)SnJ
001069	B10.RIII-H2^r/(71NS)nMobJ
001760	B10.S-H2^as1/(8R)/J
001953	B10.S-H2^s/SgMcdJ
001817	B10.S-H2^sm1/(12R)SgJ
001650	B10.S-H2^t4/(9R)/J
000456	B10.SM H2^v H2-T18^b/(70NS)Sn-cw/J
001155	B10.T-H2^y2/(6R)SgDvEgJ
000445	B10.WB-H2^j H2-T18^b/SnJ
000444	B10.Y-H2^pa H2-T18^c/SnJ
003483	B6 x B10.D1-H2^q/SgJ-Nox3^het-2J/J
003561	B6 x B10.PL-H2^u/(73NS)Sn-Hxl/J
002995	B6 x C.B10-H2^b/LiMcdJ-Fbn2^fp-2J/J
003584	B6.129S2-H2^dlAb1-Ea/J
001148	B6.AK-H2^k/FlaEgJ
001895	B6.AK-H2^k/J
001160	B6.C-H2^bm10/KhEgJ
001161	B6.C-H2^bm11/KhEgJ
000364	B6.C-H2^bm2/ByJ
000369	B6.C-H2^bm4/ByJ
001158	B6.C-H2^bm7/KhEgJ
000360	B6.C-H2^d Mdmg1^BALB/cBy/aByJ
000359	B6.C-H2^d/bByJ
001429	B6.C-H2^g6/J
007958	B6.Cg-H2^b3/FlaCmwJ
007959	B6.Cg-H2^b4/FlaCmwJ
000944	B6.SJL-H2^b C3^c/2CyJ
000966	B6.SJL-H2^s C3^c/1CyJ
000945	B6.SW/1CyJ
003374	B6;129S2-H2^dlAb1-Ea/J
003240	B6;B10.A-H2^a-Tg(H2KmPCC)2939Stoe/J
002844	BALB.5R-H2ⁱ⁵/LilJ
001165	BALB/c-H2^dm2/KhEgJ
001041	BKS.B6-H2^b/J
001892	BRVR.B10-H2^b/J
001893	BRVR.D2-H2^d/J
002845	C.B-H2^b Tg(H2-D^d)D8Gja/LilJ
001952	C.B10-H2^b/LilMcdJ
001951	C.C3-H2^k/LilMcdJ
000443	C3.HTG-H2^g H2-T18^b^?/SnJ
000441	C3.JK-H2^j H2-T18^b/SnJ
000440	C3.LG-H2^ar1/CkcCyJ
000439	C3.NB-H2^p H2-T18^c^?/SnJ
000438	C3.SW-H2^b/SnJ
000473	C3H-H2^o2 C4b^b/SfSnJ
001156	C57BL/6J-H2^bm3/EgJ
001157	C57BL/6Kh-H2^bm5/KhEgJ
000437	D1.C-H2^d H2-T18^c/SnJ
000436	D1.DA-H2^qp1/SnJ
000435	D1.LP-H2^b H2-T18^b^?/SnJ
000434	LP.RIII-H2^r H2-T18^b/SnJ
001383	LT.MA-Glo1^b H2^k/J
002591	NOD.B10Sn-H2^b/J
006935	NOD.Cg-H2^b thnh/J
004447	NOD.Cg-H2^h4/DilTacUmmJ
001626	NOD.NON-H2^nb1/LtJ
002032	NOD.SW-H2^q/J
002974	STOCK Es1^e H2^d/J
001308	STOCK H2^473a/J
003153	WLC.C-H2^d.GR-Mtv2/MorJ
003154	WLC.C-H2^d/MorJ

Strain Name:

B6(NOD) H2g7-Sostdc1shk/J

Stock Number:

005717

Availability:

Repository- Live

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Sostdc1shk/Sostdc1shk

Sostdc1shk/Sostdc1shk

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See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms of Use

Contact information

Contracts Administration

JAX® Mice, Products & Services Conditions of Use

No Warranty

No Liability

B6(NOD) H2^g7-Sostdc1^shk/J

Sostdc1^shk/Sostdc1^shk

Sostdc1^shk/Sostdc1^shk

JAX^® Mice, Products & Services Conditions of Use