JAX Mice Database - 005717 B6(NOD) H2<g7>-Sostdc1<shk>/J

Strain Name:	B6(NOD) H2^g7-Sostdc1^shk/J
Stock Number:	005717
Availability:	Repository- Live

Description
Phenotype
Genes & alleles
Genotyping
Health & husbandry
References
Purchasing information
Terms of Use

Description

Strain Information

Type Major Histocompatibility Congenic; Mutant Strain; Spontaneous Mutation;
Additional information on Genetically Engineered Mutant Mice.

Mating System Homozygote x Heterozygote (Female x Male)

Mating System Heterozygote x Homozygote (Female x Male)

Species laboratory mouse

Generation F4 (06-SEP-05)

Development
The sharkey (shk) mutation arose spontaneously in a C57BL/6J congenic strain homozygous for the NOD derived H2^g7 and carrying a transgene. This transgene has been bred out of this strain, but the strain remains homozygous for H2^g7. This mutant subline has been maintained by sibling intercrossing sharkey phenotypic homozygotes and unaffected heterozygotes. In 2007 this strain reached generation F8.

Control Information

	Control
	Heterozygote

Considerations for Choosing Controls

Related Strains

Strains carrying H2^g7 allele

003851 ALR.NOD-(D17Mit30-D17Mit123)/Lt

005715 B6.Cg H2^g7-Tg(Ins2-CD80)3B7Flv/LwnJ

003068 B6.NOD-(Csf2-D11Mit42) (D17Mit21-D17Mit10)/J

003300 B6.NOD-(D17Mit21-D17Mit10)/LtJ

003069 B6.NOD-(D1Mit3-Bcl2) (D17Mit21-D17Mit10)/LtJ

003071 B6.NOD-(D1Mit5.1-D1Mit15) (D17Mit21-D17Mit10)/J

003067 B6.NOD-(D3Mit132-Tshb) (D17Mit21-D17Mit10)/J

003066 B6.NOD-(D6Mit54-D6Mit14) (D17Mit21-D17Mit10)/J

001627 NON.NOD-H2^g7/LtJ

View Strains carrying H2^g7 (9 strains)

Strains carrying other alleles of H2

000471 A.SW-H2^s H2-T18^b/SnJ

002089 AK.B6-H2^b Fv1^b/J

002090 AK.B6-H2^b/J

001094 AK.L-H2^b/1CyTyJ

000469 B10.A-H2^a H2-T18^a/SgSnJ

000468 B10.A-H2^h2/(2R)SgSnJ

001150 B10.A-H2^h4/(4R)SgDvEgJ

000467 B10.A-H2ⁱ⁵ H2-T18^a/(5R)SgSnJ

000465 B10.BR-H2^k H2-T18^a/SgSnJ

004804 B10.BR-H2^k H2-T18^a/SgSnJJrep

005308 B10.Cg-H2^d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ

005534 B10.Cg-H2^d Tg(Ins2-HA)165Bri/ShrmJ

006102 B10.Cg-H2^k Tg(Il2/NFAT-luc)83Rinc/J

006100 B10.Cg-H2^k Tg(NFkB/Fos-luc)26Rinc/J

005895 B10.Cg-Thy1^a H2^d Tg(TcraCl1,TcrbCl1)1Shrm/J

002024 B10.D1-H2^q/SgJ

000462 B10.D2-H2^d/n2SnJ

001153 B10.D2-H2ⁱ⁷/(107R)EgJ

000460 B10.D2-Hc⁰ H2^d H2-T18^c/o2SnJ

000461 B10.D2-Hc⁰ H2^d H2-T18^c/oSnJ

000463 B10.D2-Hc¹ H2^d H2-T18^c/nSnJ

003147 B10.D2-Hc¹ H2^d H2-T18^c/nSnJ-Tg(DO11.10)10Dlo/J

001953 B10.S-H2^s/SgMcdJ

002995 B6 x C.B10-H2^b/LiMcdJ-Fbn2^fp-2J/J

003584 B6.129S2-H2^dlAb1-Ea/J

001148 B6.AK-H2^k/FlaEgJ

001895 B6.AK-H2^k/J

000360 B6.C-H2^d Mdmg1^BALB/cBy/aByJ

000359 B6.C-H2^d/bByJ

000944 B6.SJL-H2^b C3^c/2CyJ

000966 B6.SJL-H2^s C3^c/1CyJ

000945 B6.SW/1CyJ

003374 B6;129S2-H2^dlAb1-Ea/J

003240 B6;B10.A-H2^a-Tg(H2KmPCC)2939Stoe/J

002844 BALB.5R-H2ⁱ⁵/LilJ

001041 BKS.B6-H2^b/J

001892 BRVR.B10-H2^b/J

001893 BRVR.D2-H2^d/J

001952 C.B10-H2^b/LilMcdJ

001951 C.C3-H2^k/LilMcdJ

000438 C3.SW-H2^b/SnJ

000437 D1.C-H2^d H2-T18^c/SnJ

000435 D1.LP-H2^b H2-T18^b^?/SnJ

001383 LT.MA-Glo1^b H2^k/J

002591 NOD.B10Sn-H2^b/J

004447 NOD.Cg-H2^h4/DilTacUmmJ

002032 NOD.SW-H2^q/J

003153 WLC.C-H2^d.GR-Mtv2/MorJ

003154 WLC.C-H2^d/MorJ

View Strains carrying other alleles of H2 (49 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
assigned by genotype

Sostdc1^shk/Sostdc1^shk
involves: C57BL/6J * NOD
craniofacial phenotype

abnormal hard palate (MGI Ref ID J:127012)

abnormal palatine shelf (MGI Ref ID J:127012)

asymetrical, disorganized formation

decreased skull height (MGI Ref ID J:127012)

females, but not males, have shorter skull height

decreased skull width (MGI Ref ID J:127012)

males have less skull morphological abnormalities than females, but do have smaller skull width than controls

short mandible (MGI Ref ID J:127012)

females, but not males, have a shorter jaw length than wildtype controls

supernumerary incisors (MGI Ref ID J:127012)

there is some variation in the rate of growth of these supernumerary incisors

an extra pair of upper and lower incisors erupt posterior to the normal incisors, and there are separate roots for these extra teeth

skeleton phenotype

abnormal palatine shelf (MGI Ref ID J:127012)

asymetrical, disorganized formation

decreased skull height (MGI Ref ID J:127012)

females, but not males, have shorter skull height

decreased skull width (MGI Ref ID J:127012)

males have less skull morphological abnormalities than females, but do have smaller skull width than controls

short mandible (MGI Ref ID J:127012)

females, but not males, have a shorter jaw length than wildtype controls

digestive/alimentary phenotype

abnormal hard palate (MGI Ref ID J:127012)

abnormal palatine shelf (MGI Ref ID J:127012)

asymetrical, disorganized formation

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.
Sostdc1^shk/Sostdc1^shk
involves: C57BL/6J * CAST/EiJ * NOD
craniofacial phenotype

supernumerary incisors (MGI Ref ID J:127012)

F2 homozygotes from a cross to CAST/EiJ have upper, but not lower, supernumerary incisors

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:
H2^g7 related

Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers

Sostdc1^shk related

Developmental Biology Research
Craniofacial and Palate Defects
Skeletal Defects

Genes & Alleles

Gene & Allele Information

Allele Symbol		H2^g7
Allele Name		g7 variant
Allele Type		Not Applicable
Gene Symbol and Name		H2, histocompatibility-2, MHC
Chromosome		17
Gene Common Name(s)		H-2; MHC-II;
General Note		The g7 variant has been observed in the following strains: DBR7, NON.NOD-H2^g7

Allele Symbol		Sostdc1^shk
Allele Name		sharkey
Allele Type		Spontaneous
Strain of Origin		B6.NOD-H2
Gene Symbol and Name		Sostdc1, sclerostin domain containing 1
Chromosome		12
Gene Common Name(s)		0610006G05Rik; CDA019; DKFZp564D206; ECTODIN; RIKEN cDNA 0610006G05 gene; Sostl; USAG-1; USAG1; Wise; sclerostin-like;

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

Selected Reference(s)

Giggey J; Curtain MM; Donahue LR. 2007. Sharkey, a new mutation in the Sostdc1 gene MGI Direct Data Submission :. [MGI Ref ID J:127012]

Additional References

H2^g7 related

Carrasco-Marin E; Shimizu J; Kanagawa O; Unanue ER. 1996. The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders. J Immunol 156(2):450-8. [PubMed: 8543793] [MGI Ref ID J:30538]

Fossati G; Cooke A; Papafio RQ; Haskins K; Stockinger B. 1999. Triggering a second T cell receptor on diabetogenic T cells can prevent induction of diabetes. J Exp Med 190(4):577-83. [PubMed: 10449528] [MGI Ref ID J:108724]

Gray D; Abramson J; Benoist C; Mathis D. 2007. Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J Exp Med 204(11):2521-8. [PubMed: 17908938] [MGI Ref ID J:126040]

Jasinski JM; Yu L; Nakayama M; Li MM; Lipes MA; Eisenbarth GS; Liu E. 2006. Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout. Diabetes 55(7):1978-84. [PubMed: 16804066] [MGI Ref ID J:111874]

Klein J; Figueroa F; David CS. 1983. H-2 haplotypes, genes and antigens: second listing. II. The H-2 complex. Immunogenetics 17(6):553-96. [PubMed: 6407984] [MGI Ref ID J:7097]

Leiter EH. 1998. NOD Mice and Related Strains: Origins, Husbandry and Biology Introduction. In: NOD Mice and Related Strains: Research Applications in Diabetes, AIDS, Cancer, and Other Diseases. RG Landes, Austin. [MGI Ref ID J:110093]

Levisetti MG; Lewis DM; Suri A; Unanue ER. 2008. Weak proinsulin peptide-major histocompatibility complexes are targeted in autoimmune diabetes in mice. Diabetes 57(7):1852-60. [PubMed: 18398138] [MGI Ref ID J:138230]

Luhder F; Katz J; Benoist C; Mathis D. 1998. Major histocompatibility complex class II molecules can protect from diabetes by positively selecting T cells with additional specificities. J Exp Med 187(3):379-87. [PubMed: 9449718] [MGI Ref ID J:108722]

Mahler M; Bristol IJ; Leiter EH; Workman AE; Birkenmeier EH; Elson CO; Sundberg JP. 1998. Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis. Am J Physiol 274(3 Pt 1):G544-51. [PubMed: 9530156] [MGI Ref ID J:46553]

Martin-Orozco N; Chen Z; Poirot L; Hyatt E; Chen A; Kanagawa O; Sharpe A; Mathis D; Benoist C. 2003. Paradoxical dampening of anti-islet self-reactivity but promotion of diabetes by OX40 ligand. J Immunol 171(12):6954-60. [PubMed: 14662903] [MGI Ref ID J:86926]

Pearson T; Markees TG; Serreze DV; Pierce MA; Marron MP; Wicker LS; Peterson LB; Shultz LD; Mordes JP; Rossini AA; Greiner DL. 2003. Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice. J Immunol 171(1):185-95. [PubMed: 12816997] [MGI Ref ID J:109845]

Podolin PL; Pressey A; DeLarato NH; Fischer PA; Peterson LB; Wicker LS. 1993. I-E+ nonobese diabetic mice develop insulitis and diabetes. J Exp Med 178(3):793-803. [PubMed: 8350054] [MGI Ref ID J:14178]

Serreze DV; Gallichan WS; Snider DP; Croitoru K; Rosenthal KL; Leiter EH; Christianson GJ; Dudley ME; Roopenian DC. 1996. MHC class I-mediated antigen presentation and induction of CD8+ cytotoxic T-cell responses in autoimmune diabetes-prone NOD mice. Diabetes 45(7):902-8. [PubMed: 8666141] [MGI Ref ID J:33688]

Turley SJ; Lee JW; Dutton-Swain N; Mathis D; Benoist C. 2005. Endocrine self and gut non-self intersect in the pancreatic lymph nodes. Proc Natl Acad Sci U S A 102(49):17729-33. [PubMed: 16317068] [MGI Ref ID J:104385]

Wong FS; Du W; Thomas IJ; Wen L. 2005. The influence of the major histocompatibility complex on development of autoimmune diabetes in RIP-B7.1 mice. Diabetes 54(7):2032-40. [PubMed: 15983204] [MGI Ref ID J:109830]

Yoshida T; Jiang F; Honjo T; Okazaki T. 2008. PD-1 deficiency reveals various tissue-specific autoimmunity by H-2b and dose-dependent requirement of H-2g7 for diabetes in NOD mice. Proc Natl Acad Sci U S A 105(9):3533-8. [PubMed: 18299579] [MGI Ref ID J:132764]

Zhang C; Todorov I; Lin CL; Atkinson M; Kandeel F; Forman S; Zeng D. 2007. Elimination of insulitis and augmentation of islet beta cell regeneration via induction of chimerism in overtly diabetic NOD mice. Proc Natl Acad Sci U S A 104(7):2337-42. [PubMed: 17267595] [MGI Ref ID J:119749]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports
Room Number A1

Colony Maintenance

Breeding & Husbandry Homozygotes must have their teeth trimmed and attention must be paid to their ability to eat. The rate of supernumery tooth growth varies within the strain, with the most affected homozygotes requiring tooth trimming approximately once per week. In addition to standard food pellets, ground food should be supplied in the cage.

Mating System Homozygote x Heterozygote (Female x Male)

Heterozygote x Homozygote (Female x Male)

Breeding & Husbandry	Homozygotes must have their teeth trimmed and attention must be paid to their ability to eat. The rate of supernumery tooth growth varies within the strain, with the most affected homozygotes requiring tooth trimming approximately once per week. In addition to standard food pellets, ground food should be supplied in the cage.
Mating System	Homozygote x Heterozygote (Female x Male)
	Heterozygote x Homozygote (Female x Male)

Weeks of Age	Price*	Gender	Genotypes Provided
Individual Mouse Price	$124.10	Female or Male	Homozygous for H2^g7, Heterozygous for Sostdc1^shk
	$201.10	Female or Male	Homozygous for H2^g7, Homozygous for Sostdc1^shk

Pairs /Price*	Pair Genotype
$248.20	Homozygous for H2^g7, Heterozygous for Sostdc1^shk x Homozygous for H2^g7, Heterozygous for Sostdc1^shk
$325.20	Homozygous for H2^g7, Heterozygous for Sostdc1^shk x Homozygous for H2^g7, Homozygous for Sostdc1^shk
$402.20	Homozygous for H2^g7, Homozygous for Sostdc1^shk x Homozygous for H2^g7, Homozygous for Sostdc1^shk

Supply Notes	Histology and Tissue Collection Services are available for all JAX^® Mice strains. For more information, please contact Customer Service at orderquest@jax.org or 1-800-422-6423.

Weeks of Age	Price*	Gender	Genotypes Provided
Individual Mouse Price	$161.40	Female or Male	Homozygous for H2^g7, Heterozygous for Sostdc1^shk
	$261.50	Female or Male	Homozygous for H2^g7, Homozygous for Sostdc1^shk

Pairs /Price*	Pair Genotype
$322.70	Homozygous for H2^g7, Heterozygous for Sostdc1^shk x Homozygous for H2^g7, Heterozygous for Sostdc1^shk
$422.80	Homozygous for H2^g7, Heterozygous for Sostdc1^shk x Homozygous for H2^g7, Homozygous for Sostdc1^shk
$522.90	Homozygous for H2^g7, Homozygous for Sostdc1^shk x Homozygous for H2^g7, Homozygous for Sostdc1^shk

Supply Notes	Histology and Tissue Collection Services are available for all JAX^® Mice strains. For more information, please contact Customer Service at orderquest@jax.org or 1-207-288-5845.

Standard Supply	Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes	Usually shipped between four and eight weeks of age.

Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.

Supply Notes

Usually shipped between four and eight weeks of age.

Control Information

	Control
	Heterozygote

Considerations for Choosing Controls
USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

Ordering and Purchasing Information

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Contact Information
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Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
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Terms of Use

General Terms and Conditions

Contact information

General inquiries

Contracts Administration

phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice & Services Conditions of Use

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Acceptance of delivery of MICE, products or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on The Jackson Laboratory, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, products services by The Jackson Laboratory.

003851	ALR.NOD-(D17Mit30-D17Mit123)/Lt
005715	B6.Cg H2^g7-Tg(Ins2-CD80)3B7Flv/LwnJ
003068	B6.NOD-(Csf2-D11Mit42) (D17Mit21-D17Mit10)/J
003300	B6.NOD-(D17Mit21-D17Mit10)/LtJ
003069	B6.NOD-(D1Mit3-Bcl2) (D17Mit21-D17Mit10)/LtJ
003071	B6.NOD-(D1Mit5.1-D1Mit15) (D17Mit21-D17Mit10)/J
003067	B6.NOD-(D3Mit132-Tshb) (D17Mit21-D17Mit10)/J
003066	B6.NOD-(D6Mit54-D6Mit14) (D17Mit21-D17Mit10)/J
001627	NON.NOD-H2^g7/LtJ

000471	A.SW-H2^s H2-T18^b/SnJ
002089	AK.B6-H2^b Fv1^b/J
002090	AK.B6-H2^b/J
001094	AK.L-H2^b/1CyTyJ
000469	B10.A-H2^a H2-T18^a/SgSnJ
000468	B10.A-H2^h2/(2R)SgSnJ
001150	B10.A-H2^h4/(4R)SgDvEgJ
000467	B10.A-H2ⁱ⁵ H2-T18^a/(5R)SgSnJ
000465	B10.BR-H2^k H2-T18^a/SgSnJ
004804	B10.BR-H2^k H2-T18^a/SgSnJJrep
005308	B10.Cg-H2^d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005534	B10.Cg-H2^d Tg(Ins2-HA)165Bri/ShrmJ
006102	B10.Cg-H2^k Tg(Il2/NFAT-luc)83Rinc/J
006100	B10.Cg-H2^k Tg(NFkB/Fos-luc)26Rinc/J
005895	B10.Cg-Thy1^a H2^d Tg(TcraCl1,TcrbCl1)1Shrm/J
002024	B10.D1-H2^q/SgJ
000462	B10.D2-H2^d/n2SnJ
001153	B10.D2-H2ⁱ⁷/(107R)EgJ
000460	B10.D2-Hc⁰ H2^d H2-T18^c/o2SnJ
000461	B10.D2-Hc⁰ H2^d H2-T18^c/oSnJ
000463	B10.D2-Hc¹ H2^d H2-T18^c/nSnJ
003147	B10.D2-Hc¹ H2^d H2-T18^c/nSnJ-Tg(DO11.10)10Dlo/J
001953	B10.S-H2^s/SgMcdJ
002995	B6 x C.B10-H2^b/LiMcdJ-Fbn2^fp-2J/J
003584	B6.129S2-H2^dlAb1-Ea/J
001148	B6.AK-H2^k/FlaEgJ
001895	B6.AK-H2^k/J
000360	B6.C-H2^d Mdmg1^BALB/cBy/aByJ
000359	B6.C-H2^d/bByJ
000944	B6.SJL-H2^b C3^c/2CyJ
000966	B6.SJL-H2^s C3^c/1CyJ
000945	B6.SW/1CyJ
003374	B6;129S2-H2^dlAb1-Ea/J
003240	B6;B10.A-H2^a-Tg(H2KmPCC)2939Stoe/J
002844	BALB.5R-H2ⁱ⁵/LilJ
001041	BKS.B6-H2^b/J
001892	BRVR.B10-H2^b/J
001893	BRVR.D2-H2^d/J
001952	C.B10-H2^b/LilMcdJ
001951	C.C3-H2^k/LilMcdJ
000438	C3.SW-H2^b/SnJ
000437	D1.C-H2^d H2-T18^c/SnJ
000435	D1.LP-H2^b H2-T18^b^?/SnJ
001383	LT.MA-Glo1^b H2^k/J
002591	NOD.B10Sn-H2^b/J
004447	NOD.Cg-H2^h4/DilTacUmmJ
002032	NOD.SW-H2^q/J
003153	WLC.C-H2^d.GR-Mtv2/MorJ
003154	WLC.C-H2^d/MorJ

Strain Name:

B6(NOD) H2g7-Sostdc1shk/J

Stock Number:

005717

Availability:

Repository- Live

Strain Information

Control Information

Related Strains

Phenotype Information

Sostdc1shk/Sostdc1shk

Sostdc1shk/Sostdc1shk

Gene & Allele Information

Genotyping Information

Helpful Links

References

Selected Reference(s)

Additional References

Health & Colony Maintenance Information

Animal Health Reports

Colony Maintenance

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Additional Supply Details

Additional Supply Details

Supply Details

Control Information

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

Terms of Use

Contact information

Contracts Administration

JAX® Mice & Services Conditions of Use

No Warranty

No Liability

B6(NOD) H2^g7-Sostdc1^shk/J

Sostdc1^shk/Sostdc1^shk

Sostdc1^shk/Sostdc1^shk

JAX^® Mice & Services Conditions of Use