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Strain Name: |
STOCK Tg(tetO-Ipf1,lacZ)958.1Macd/J |
Stock Number: |
005728 |
Availability:
| Repository-Cryopreserved |
Product Information
Strain Details
| Type |
JAX® GEMM® Strain -
Mutant Stock |
| Additional information on
JAX® GEMM® Strains. |
| Type |
JAX® GEMM® Strain -
Mutant Strain |
| Type |
JAX® GEMM® Strain -
Transgenic |
| Species | laboratory mouse |
| Donating Investigator | Raymond MacDonald, UTSW Medical Center |
|
|
Strain Description
Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any behavioral abnormalities. Expression of the bicistronic transgene is under the regulation of a tetracycline-responsive promoter element (TRE; tetO). When transgenic mice are bred to a second transgenic strain expressing tetracycline-transactivator (tTA) protein under the control of a tissue-specific promoter, the bitransgenic offspring express Ipf1 and lacZ in the appropriate target tissue. Further, Ipf1 and lacZ expression in bitransgenic mice can be suppressed by administration of the tetracycline analog, doxycycline. All cells expressing Ipf1 coexpress the reporter, and mRNA levels of the transgenic and endogenous Ipf1 fluctuate in concert during development.
This mouse was designed originally to be mated to an pancreatic targeted mutant with tTAoff in place of the Ipf1 gene (see Stock No. 005701). The combined mutations allow normal pancreatic development and function until doxycycline treatment renders the double mutant mouse conditionally null for Ipf1 expression. In these double transgenic animals, pancreatic developmental can be arrested at stage during embyronic development or in adult mice. Such double mutant mice may be useful in studies of pancreatic endocrine/exocrine function and diabetes. Tg(tetO-Ipf1,lacZ)958.1Macd transgenic mice also may be bred with other tTA strains for conditional mutation analysis.
Strain Development
A bicistronic transgenic vector was generated containing an Ipf1 minigene (both exons linked with a shortened intron and preceded by a truncated 5' untranslated region) and an internal ribosome entry site-linked beta-galactosidase (lacZ) all under transcriptional control of a tetracycline-responsive regulatory element (TRE). Transgenic mice were generated by pronuclear injection of the construct into fertilized [C57BL/6 x SJL] F1 hybrid embyros. Two-cell stage eggs were implanted into pseudopregnant foster mothers. Founder line 958.1 was obtained and was maintained by transgenic positive sibling intercross. At some point, transgenic mice were bred to B6;129 mice with a targeted mutation. The targeted mutation was selected against in subsequent breedings, and the transgenic line was again maintained by hemizygous intercrosses prior to cryopreservation.
Mammalian Phenotype Terms assigned by genotype
The following phenotype relates to a compound genotype created using this strain. Contact JAX® Services jaxservices@jax.org for customized breeding options.
Pdx1tm1Macd/Pdx1tm1Macd Tg(tetO-Ipf1,lacZ)958.1Macd/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
- homeostasis/metabolism phenotype
- impaired glucose tolerance
(MGI Ref ID J:103522)
- transgenic mice gradually attain an impaired glucose tolerance response to glucose challenge
- endocrine/exocrine gland phenotype
- abnormal pancreas development
(MGI Ref ID J:103522)
- when dams are treated with doxycycline from conception through birth, only small epithelial remnants of the pancreas form; treatment at E7.5 or E8.5 results in the same phenotype
- doxycycline from E9.5 diminishes epithelial morphogenesis; treatement from E9.5 allows outgrowth of a linear epithelial tube with nascent invaginations representing initial primary branching
- treatment from E11.5 allows the formation of a larger crude duct-like structure with a few distal primary branches; treatement from E12.5 permits formation of extensive fine structure consisting of immature acini and associated small ductules
- with treatment from E12.5, pancreatic dorsal and ventral remnants composed of convoluted partially branched duct-like epithelium of columnar epithelium are present, and show a block at the stage of acinar cell formation
- examination of embryo ductal remnants from mice treated with dox from E11.5 show an absence of preacini; treatment from E12.5 results in a larger remnant with a smaller proportion of primitive duct; the epithelium is replaced by numerous eosinophilic clusters lacking ductal markers which are polarized, arranged around a central lumen and resemble immature acini
- absent pancreas
(MGI Ref ID J:103522)
- ~1/5 pups are born without a pancreas; rescue of pancreas formation is observed in ~80% of transgenic mice
- digestive/alimentary phenotype
- abnormal pancreas development
(MGI Ref ID J:103522)
- when dams are treated with doxycycline from conception through birth, only small epithelial remnants of the pancreas form; treatment at E7.5 or E8.5 results in the same phenotype
- doxycycline from E9.5 diminishes epithelial morphogenesis; treatement from E9.5 allows outgrowth of a linear epithelial tube with nascent invaginations representing initial primary branching
- treatment from E11.5 allows the formation of a larger crude duct-like structure with a few distal primary branches; treatement from E12.5 permits formation of extensive fine structure consisting of immature acini and associated small ductules
- with treatment from E12.5, pancreatic dorsal and ventral remnants composed of convoluted partially branched duct-like epithelium of columnar epithelium are present, and show a block at the stage of acinar cell formation
- examination of embryo ductal remnants from mice treated with dox from E11.5 show an absence of preacini; treatment from E12.5 results in a larger remnant with a smaller proportion of primitive duct; the epithelium is replaced by numerous eosinophilic clusters lacking ductal markers which are polarized, arranged around a central lumen and resemble immature acini
- absent pancreas
(MGI Ref ID J:103522)
- ~1/5 pups are born without a pancreas; rescue of pancreas formation is observed in ~80% of transgenic mice
|
Gene & Allele Details
| Allele Symbol |
Tg(tetO-Ipf1,lacZ)958.1Macd |
| Allele Name |
transgene insertion 958-1, Raymond J MacDonald |
| Common Name(s) |
Pdx1-nlacZ;
TgPdx1-lacZ;
TgPdx1-nlacZ;
TgPdx1;
tetO-Pdx1;
tetO-Pdx1-nlacZ;
tetO-Pdx1/lacZ;
tetO-Pdx1/nlacZ;
|
| Mutation Made By | Raymond MacDonald, UTSW Medical Center |
| Strain of Origin | (C57BL/6 x SJL)F2 |
| Site of Expression | When crossed with a strain expressing tTA, bitransgenic progeny express the transgene in the target tissue. Expression of the transgene can be suppressed by the administration of tetracycline or its analog, doxycyline. |
| Expressed Gene |
Pdx1,
pancreatic and duodenal homeobox 1, mouse, laboratory |
| Expressed Gene |
lacZ, beta-galactosidase, E. coli |
| Promoter |
tetO, tet operator, |
| Molecular Note |
A transgenic vector was generated containing an Ipf1 minigene (both exons linked with a shortened intron). The Ipf1 gene was preceded by a truncated 5' UTR and an IRES-linked beta-galactosidase (lacZ) gene under transcriptional control of 7 direct repeats of the tetracycline operator sequence (tetO) fused to the human cytomegalovirus immediate-early promoter. [MGI Ref ID J:103522]
|
Control Information
Genotyping Protocols
Generic LacZ QPCR
Tg(LacZ) Generic
Colony Maintenance
| Breeding & Husbandry | When maintaining a live colony, these mice are maintained as hemizygotes by transgenic positive sibling intercross. |
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| 002938 | B6.129-Kdrtm1Jrt/J |
| 004158 | B6.129-Maftm1Gsb/J |
| 006497 | B6.129-Skiltm2Spw/J |
| 005772 | B6.129P2-Acvrl1tm1Dgen/J |
| 006431 | B6.129P2-Adam21tm1Dgen/J |
| 005770 | B6.129P2-Adamts4tm1Dgen/J |
| 005771 | B6.129P2-Adamts5tm1Dgen/J |
| 005773 | B6.129P2-Adcy3tm1Dgen/J |
| 005774 | B6.129P2-Adcy7tm1Dgen/J |
| 005775 | B6.129P2-Adipor2tm1Dgen/J |
| 005776 | B6.129P2-Avpr1atm1Dgen/J |
| 005777 | B6.129P2-Axltm1Dgen/J |
| 005783 | B6.129P2-Cacna1ctm1Dgen/J |
| 005780 | B6.129P2-Cacna2d3tm1Dgen/J |
| 005781 | B6.129P2-Cacng3tm1Dgen/J |
| 005782 | B6.129P2-Cacng4tm1Dgen/J |
| 005784 | B6.129P2-Capn5tm1Dgen/J |
| 005785 | B6.129P2-Capn7tm1Dgen/J |
| 005792 | B6.129P2-Ccr1l1tm1Dgen/J |
| 005793 | B6.129P2-Ccr6tm1Dgen/J |
| 005794 | B6.129P2-Ccr7tm1Dgen/J |
| 005779 | B6.129P2-Celsr2tm1Dgen/J |
| 005797 | B6.129P2-Chrna2tm1Dgen/J |
| 005787 | B6.129P2-Ctsctm1Dgen/J |
| 005796 | B6.129P2-Cxcr3tm1Dgen/J |
| 005798 | B6.129P2-Drd5tm1Dgen/J |
| 005800 | B6.129P2-Efemp2tm1Dgen/J |
| 005801 | B6.129P2-Esrratm1Dgen/J |
| 005802 | B6.129P2-Faim2tm1Dgen/J |
| 005803 | B6.129P2-Fzd1tm1Dgen/J |
| 005804 | B6.129P2-Fzd8tm1Dgen/J |
| 005811 | B6.129P2-Gabra3tm1Dgen/J |
| 005812 | B6.129P2-Gabra4tm1Dgen/J |
| 005810 | B6.129P2-Gabrptm1Dgen/J |
| 005809 | B6.129P2-Galr1tm1Dgen/J |
| 005816 | B6.129P2-Glra3tm1Dgen/J |
| 005805 | B6.129P2-Gpr151tm1Dgen/J |
| 005806 | B6.129P2-Gpr37tm1Dgen/J |
| 005807 | B6.129P2-Gpr6tm1Dgen/J |
| 005813 | B6.129P2-Grik5tm1Dgen/J |
| 005808 | B6.129P2-Grk5tm1Dgen/J |
| 005814 | B6.129P2-Grm1tm1Dgen/J |
| 005815 | B6.129P2-Grm3tm1Dgen/J |
| 005817 | B6.129P2-Gsk3btm1Dgen/J |
| 005818 | B6.129P2-Hcrtr1tm1Dgen/J |
| 005767 | B6.129P2-Htr4tm1Dgen/J |
| 005769 | B6.129P2-Htr7tm1Dgen/J |
| 005830 | B6.129P2-Kcnq2tm1Dgen/J |
| 005821 | B6.129P2-Lats2tm1Dgen/J |
| 005822 | B6.129P2-Lmbr1tm1Dgen/J |
| 005850 | B6.129P2-Mapkapk2tm1Dgen/J |
| 005824 | B6.129P2-Mmp17tm1Dgen/J |
| 005825 | B6.129P2-Mtmr1tm1Dgen/J |
| 005778 | B6.129P2-Naip1tm1Dgen/J |
| 005826 | B6.129P2-Ntsr1tm1Dgen/J |
| 005829 | B6.129P2-Pkd2l2tm1Dgen/J |
| 005828 | B6.129P2-Ppardtm1Dgen/J |
| 005831 | B6.129P2-Ppm1ftm1Dgen/J |
| 005827 | B6.129P2-Ptch2tm1Dgen/J |
| 005832 | B6.129P2-Ptprotm1Dgen/J |
| 005799 | B6.129P2-S1pr4tm1Dgen/J |
| 005837 | B6.129P2-Scn11atm1Dgen/J |
| 005836 | B6.129P2-Scn9atm1Dgen/J |
| 005834 | B6.129P2-Sema5atm1Dgen/J |
| 005835 | B6.129P2-Sema6ctm1Dgen/J |
| 006432 | B6.129P2-Slc18a1tm1Dgen/J |
| 005839 | B6.129P2-Slc22a12tm1Dgen/J |
| 005838 | B6.129P2-Slc22a6tm1Dgen/J |
| 005840 | B6.129P2-Slc40a1tm1Dgen/J |
| 005841 | B6.129P2-Slc6a9tm1Dgen/J |
| 005842 | B6.129P2-Slc7a8tm1Dgen/J |
| 005843 | B6.129P2-Slc9a6tm1Dgen/J |
| 005844 | B6.129P2-Sstr1tm1Dgen/J |
| 005847 | B6.129P2-Tgfbr1tm1Dgen/J |
| 005845 | B6.129P2-Thbs4tm1Dgen/J |
| 005790 | B6.129P2-Tpp1tm1Dgen/J |
| 005848 | B6.129P2-Trpm5tm1Dgen/J |
| 005791 | B6.129P2-Xcr1tm1Dgen/J |
| 003474 | B6.129S4-Gt(ROSA)26Sortm1Sor/J |
| 005901 | B6.129S4-Ppardtm2Rev/J |
| 006142 | B6.129S4-Ppargtm1Rev/J |
| 003754 | B6.129S4-Shroom3Gt(ROSA)53Sor/J |
| 005119 | B6.129S6-Npas2tm1Slm/J |
| 002741 | B6.129S7-Alpltm1Sor/J |
| 005970 | B6.129S7-Atoh1tm2Hzo/J |
| 006039 | B6.129S7-Efnb2tm1And/J |
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| 006958 | B6;129S-Nkd1tm1Kwha/J |
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| 007204 | B6;129S4-2610005L07RikGt(ROSA)73Sor/J |
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| 002317 | B6;129S7-Alpltm1Sor/J |
| 003266 | B6;129S7-Epas1tm1Rus/J |
| 006044 | B6;129S7-Ephb4tm1And/J |
| 003471 | B6;C3H-Tg(CNP-GEO)1Ldh/J |
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| 006680 | B6;CBA-Tg(Olfr16*,taulacZ)19Mom/MomJ |
| 006671 | B6;CBA-Tg(Olfr16*,taulacZ)5Mom/MomJ |
| 006672 | B6;CBA-Tg(Olfr16*,taulacZ)7Mom/MomJ |
| 006673 | B6;CBA-Tg(Olfr16,taulacZ)sn2Mom/MomJ |
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| 005024 | FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/J |
| 005026 | FVB.Cg-Tg(SMN2)89Ahmb Tg(SMN1*A2G)2023Ahmb Smn1tm1Msd/J |
| 005025 | FVB.Cg-Tg(SMN2*delta7)4299Ahmb Tg(SMN2)89Ahmb Smn1tm1Msd/J |
| 003140 | FVB/N-Tg(PAI1-lacZ)1Jjb/J |
| 002856 | FVB/N-Tg(TIE2-lacZ)182Sato/J |
| 005941 | FVB/N-Tg(tetO-Aurkb,lacZ)41Kra/J |
| 003315 | FVB/N-Tg(tetORo1-lacZ)3Conk/J |
| 003487 | FVB/NJ-Tg(XGFAP-lacZ)3Mes/J |
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| 008212 | STOCK Smn1tm1Msd Tg(Prnp-SMN)92Ahmb Tg(SMN2)89Ahmb/J |
| 006882 | STOCK Tg(CAG-Bgeo,-AML1/ETO,-ALPP)1Lbe/J |
| 005438 | STOCK Tg(CAG-Bgeo,-DsRed*MST)1Nagy/J |
| 006850 | STOCK Tg(CAG-Bgeo,-NOTCH1,-EGFP)1Lbe/J |
| 006876 | STOCK Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe/J |
| 006613 | STOCK Tg(CAG-Bgeo,-Tle1,-ALPP)1Lbe/J |
| 003919 | STOCK Tg(CAG-Bgeo/ALPP)1Lbe/J |
| 003920 | STOCK Tg(CAG-Bgeo/GFP)21Lbe/J |
| 004623 | STOCK Tg(Fos-lacZ)34Efu/J |
| 006674 | STOCK Tg(Olfr16,taulacZ)2030Mom/MomJ |
| 005493 | STOCK Tg(Tek-rtTA,TRE-lacZ)1425Tpr/J |
| 002395 | STOCK Tg(Zfy1-lacZ)218Bri/J |
| 003274 | STOCK Tg(tetNZL)2Bjd/J |
View lacZ Expression Strains (174 strains)
Strains carrying other alleles of Pdx1
View Strains carrying other alleles of Pdx1 (2 strains)
Strains carrying other alleles of lacZ
View Strains carrying other alleles of lacZ (36 strains)
Strains carrying other alleles of tetO
View Strains carrying other alleles of tetO (28 strains)
Additional Web Information
Fluorescent Proteins/lacZ Systems
Tet Expression Systems
Research Applications
This mouse can be used to support research in many areas including:
Endocrine Deficiency Research
Pancreas Defects
Metabolism Research
Enzyme Deficiency
(exocrine pancreatic insufficiency)
Research Tools
lacZ Expression
Diabetes and Obesity Research
(lacZ)
Genetics Research
(Mutagenesis and Transgenesis: Tetop Tet System)
Genetics Research
(Tissue/Cell Markers: multiple)
Genetics Research
(Tissue/Cell Markers: pancreatic beta cells)
Tet Expression Systems
(tTA/rtTA Responsive Strains)
Tet Expression Systems
lacZ related
Research Tools
lacZ Expression
References
Selected Reference(s)
Hale MA; Kagami H; Shi L; Holland AM; Elsasser HP; Hammer RE; MacDonald RJ. 2005. The homeodomain protein PDX1 is required at mid-pancreatic development for the formation of the exocrine pancreas. Dev Biol
286(1):225-37.
[PubMed: 16126192]
[MGI Ref ID J:103522]
Price and Supply Information
| Strain Name: |
STOCK Tg(tetO-Ipf1,lacZ)958.1Macd/J |
| Stock Number: |
005728 |
Price Details
IMPORTANT NOTE: Prices are based on shipping destination.
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
| Supply Notes |
Cryopreserved Embryos This strain is also available as cryopreserved embryos from our Repository. Orders for cryopreserved embryos are supplied subject to a signed agreement that must be returned to the Customer Service Department after order placement. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos from our repository, please visit our Cryopreserved Embryos web page.
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice. One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services: Tel: 1-800-422-6423 or 1-207-288-5845; Email: jaxservices@jax.org.
This strain is included in the Induced Mutant Resource Colony collection.
|
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for Licensing and Use Restrictions
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| Control Information | View Control Information in Strain Details.
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JAX® Mice & Services Conditions of Use.
Use of the Tet-System may require a license, see Licenses for Strains Using TET-System Technology.
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