Strain Name:

BKS(Cg)-calre/J

Stock Number:

005736

Availability:

Repository-Cryopreserved

Description

Strain Information

Former Names BKS.Cg m +/+ Leprdb/J-calre/J    (Changed: 02-APR-07 )
BKS.Cg-m +/+ Leprdb/J-calre/J    (Changed: 23-NOV-05 )
Type Coisogenic; Congenic; Mutant Strain; Spontaneous Mutation;
Additional information on Genetically Engineered Mutant Mice.
Mating SystemHomozygote x Heterozygote         (Female x Male)
Mating SystemHeterozygote x Homozygote         (Female x Male)
Specieslaboratory mouse

Important Note
This strain may still be segregating for the misty (m) and diabetes (Leprdb) mutations.

Description
The curly coat of this spontaneous homozygous mutant mouse (BKS.Cg m +/+ Leprdb /J-calre/J) is recognized at 10-12 days of age when hair is fully covering the body. At 2 weeks of age the coat of homozygous mutants looks very curly, and the mutants also have curly vibrissae. After several weeks, the curly phenotype is reduced; the hair becomes fuzzy in appearance, and the vibrissae straighten out and appear normal. Some mutant mice have no whiskers at wean age. Also, in older homozygous and heterzygous mice more whiskers are lost, and homozygous mutants lose more hair as they age. Homozygous mutant mice live normal life spans and breed normally.

Control Information

  Control
   Heterozygote from the colony
 
  Considerations for Choosing Controls

Additional Web Information

Genetic Quality Control Annual Report

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

calre/calre

        BKS.Cg m +/+ Leprdb/J-calre
  • skin/coat/nails phenotype
  • *normal* skin/coat/nails phenotype (MGI Ref ID J:100248)
    • skin sections are histologically normal
    • abnormal coat appearance (MGI Ref ID J:100248)
      • after several weeks of age, the hair appears fuzzy
      • waved hair (MGI Ref ID J:100248)
        • at 2 weeks of age, the coat is very curly
        • with age, the phenotype is reduced
    • abnormal zigzag hairs (MGI Ref ID J:100248)
      • zigzag hairs have abnormal bends and kinks
    • alopecia (MGI Ref ID J:100248)
      • with increased age, mice lose hair
  • touch/vibrissae phenotype
  • absent vibrissae (MGI Ref ID J:100248)
    • some mice have no vibrissae at weaning age
    • with age, vibrissae are lost
  • curly vibrissae (MGI Ref ID J:100248)
    • at 2 weekd of age, the vibrissae are very curly
    • with age, the vibrissae straighten out and appear normal
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

calre related

Dermatology Research
Skin and Hair Texture Defects

Developmental Biology Research
Skin and Hair Texture Defects

Genes & Alleles

Gene & Allele Information

Allele Symbol calre
Allele Name caracul-like recessive
Allele Type Spontaneous
Strain of OriginBKS.Cg-m +/+ Leprdb/J

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Karst SY; Ward-Bailey PF; Donahue LR; Bronson RT; Johnson KR; Davisson MT. 2005. Caracul-like recessive: a mutation of the Cal gene MGI Direct Data Submission :.  [MGI Ref ID J:100248]

Original article from The Mouse Mutant Resource

Health & husbandry

Health & Colony Maintenance Information

Colony Maintenance

Mating SystemHomozygote x Heterozygote         (Female x Male)
Heterozygote x Homozygote         (Female x Male)

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Weeks of AgePrice*Gender
Cryorecovery Fee $1900.00
*Price(s) in US dollars ($)

Additional Supply Details

Pricing for International shipping destinations View USA Canada and Mexico pricing
Weeks of AgePrice*Gender
Cryorecovery Fee $2470.00
*Price(s) in US dollars ($)

Additional Supply Details

Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes
  • Cryorecovery - Standard.
    The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845.

  • This strain is included in the Mouse Mutant Resource collection.
Important NoteThis strain may still be segregating for the misty (m) and diabetes (Leprdb) mutations.

Control Information

  Control
   Heterozygote from the colony
 
  Considerations for Choosing Controls
  USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
  International - Control Pricing Information for Genetically Engineered Mutant Strains.

General Terms and Conditions


See Terms of Use


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering and Purchasing Information

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Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries

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phone:207-288-6470
fax:207-288-6655

JAX® Mice & Services Conditions of Use

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