Type Conplastic; Visit our online Nomenclature tutorial. Mating System Homozygote x Homozygote (Female x Male) 11-DEC-12 Species laboratory mouse and M. m. musculus Background Strain C57BL/6J Donor Strain PWD/Ph H2 Haplotype b Generation ?+F11 (30-JUN-11)
Related Genotype: a/a
This strain represents one of a panel of inter-species chromosome substitution (or consomic) strains (IC-ISS). Each strain carries a chromosome from the Mus musculus musculus wild-derived strain PWD/Ph introgressed into a Mus musculus domesticus C57BL/6J background. The two species are believed to have diverged 350,000 to one million years ago and exhibit multiple genetic and phenotypic differences. The strain set also includes a conplastic strain (mtPWD/Ph) created by sequential backcrossing of the donor female to the host male. A conplastic strain carries the mitochondrial genome of the donor strain. The IC-ISS strains represent a tool for dissection of quantitative trait loci.
Dr. Jiri Forejt from The Institute of Molecular Genetics, Prague, Czech Republic developed the C57BL/6J-mtPWD/Ph/ForeJ conplastic strain by sequential backcrossing of the PWD/Ph donor female to the C57BL/6J host male (See SNP note below). A conplastic strain carries the mitochondrial genome of the donor strain. The set was donated to The Jackson Laboratory in 2005.
A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, 1 of 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to The Jackson Laboratory Repository were on a mixed C57BL/6J ; C57BL/6N genetic background.
|Considerations for Choosing Controls|
B6/PWD Consomic Panel
007600 C57BL/6J-Chr 10.1PWD/Ph/ForeJ 007601 C57BL/6J-Chr 10.2PWD/Ph/ForeJ 006599 C57BL/6J-Chr 10.3PWD/Ph/ForeJ 005997 C57BL/6J-Chr 11.1PWD/Ph/ForeJ 005998 C57BL/6J-Chr 11.2PWD/Ph/ForeJ 006372 C57BL/6J-Chr 11.3PWD/Ph/ForeJ 005263 C57BL/6J-Chr 12PWD/Ph/ForeJ 005519 C57BL/6J-Chr 13PWD/Ph/ForeJ 005264 C57BL/6J-Chr 14PWD/Ph/ForeJ 005265 C57BL/6J-Chr 15PWD/Ph/ForeJ 005266 C57BL/6J-Chr 16PWD/Ph/ForeJ 005267 C57BL/6J-Chr 17PWD/Ph/ForeJ 005268 C57BL/6J-Chr 18PWD/Ph/ForeJ 005269 C57BL/6J-Chr 19PWD/Ph/ForeJ 005259 C57BL/6J-Chr 1PWD/Ph/ForeJ 005995 C57BL/6J-Chr 2PWD/Ph/ForeJ 005518 C57BL/6J-Chr 3PWD/Ph/ForeJ 006226 C57BL/6J-Chr 4PWD/Ph/ForeJ 005260 C57BL/6J-Chr 5PWD/Ph/ForeJ 005261 C57BL/6J-Chr 6PWD/Ph/ForeJ 005996 C57BL/6J-Chr 7PWD/Ph/ForeJ 006597 C57BL/6J-Chr 8PWD/Ph/ForeJ 005262 C57BL/6J-Chr 9PWD/Ph/ForeJ 005762 C57BL/6J-Chr X.1PWD/Ph/ForeJ 006598 C57BL/6J-Chr X.2PWD/Ph/ForeJ 006227 C57BL/6J-Chr X.3PWD/Ph/ForeJ 005270 C57BL/6J-Chr YPWD/Ph/ForeJView B6/PWD Consomic Panel (27 strains)
View Phenotypic DataPhenotypic DataView Research ApplicationsResearch ApplicationsThis mouse can be used to support research in many areas including:
Gene Mapping: Tools for QTL Mapping, Segregation and Linkage Analysis
Animal Health ReportsRoom Number AX11
Breeding & Husbandry When maintaining a live colony, homozygous mice may be bred together. Mating System Homozygote x Homozygote (Female x Male) 11-DEC-12 Diet Information LabDiet® 5K52/5K67
|Pricing for USA, Canada and Mexico shipping destinations|
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $110.00 Female or Male Homozygous
Price per Pair (US dollars $) Pair Genotype $220.00 Homozygous x Homozygous
|Pricing for International shipping destinations|
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $143.00 Female or Male Homozygous
Price per Pair (US dollars $) Pair Genotype $286.00 Homozygous x Homozygous
|Considerations for Choosing Controls|
|Control Pricing Information for Genetically Engineered Mutant Strains.|
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