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Strain Name:

B6.129P2-Adipor2tm1Dgen/J

Stock Number:

005775

Availability:

Repository- Live

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Genes & Alleles   Adipor2;   Adipor2tm1Dgen;

Product Information

Strain Details

Type JAX® GEMM® Strain - Congenic
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Mutant Strain
Type JAX® GEMM® Strain - Targeted Mutation
Specieslaboratory mouse
Generation?+N1F4 (24-OCT-07)

Strain Description
This targeted mutant was created and characterized by Deltagen, Inc. View phenotypic data developed by Deltagen.

Strain Development
The construct insert is reported to be "LacO-SA-IRES-lacZ-Neo555G/Kan." Upon arrival at The Jackson Laboratory, these mice had been backcrossed at least 6 generations to C57BL/6 mice.

Mammalian Phenotype Terms assigned by genotype

Adipor2tm1Dgen/Adipor2tm1Dgen

        B6.129P2-Adipor2tm1Dgen
  • homeostasis/metabolism phenotype
  • abnormal hormone level (MGI Ref ID J:122027)
    • decreased circulating insulin level (MGI Ref ID J:122027)
      • on a high fat diet, fasting insulin levels in females are 76% lower
    • increased adiponectin level (MGI Ref ID J:122027)
      • adiponectin levels are elevated in females on normal chow
  • abnormal lipid homeostasis (MGI Ref ID J:122027)
    • abnormal triglyceride level (MGI Ref ID J:122027)
      • on normal chow or after a high fat diet, liver triglyceride levels are lower
    • decreased circulating cholesterol level (MGI Ref ID J:122027)
      • regardless of diet, plasma cholesterol levels are reduced
      • decreased circulating HDL cholesterol level (MGI Ref ID J:122027)
  • improved glucose tolerance (MGI Ref ID J:122027)
    • on a high fat diet, glucose response in females is 9% lower than in controls
  • increased energy expenditure (MGI Ref ID J:122027)
    • energy expenditure is increased
    • however, respiratory exchange ratio is unchanged
    • resistance to diet-induced obesity (MGI Ref ID J:122027)
      • males and females are lean on regular chow and are resistant to high fat diet weight gain
  • adipose tissue phenotype
  • abnormal adipose tissue morphology (MGI Ref ID J:122027)
    • at 8 weeks on a high fat diet, females have smaller adipocytes
    • abnormal brown adipose tissue morphology (MGI Ref ID J:122027)
      • at 8 weeks on a high fat diet, females brown adipose tissue has less vacuoles
      • brown adipose tissue contains more mitochondria
      • decreased brown adipose tissue amount (MGI Ref ID J:122027)
        • after 11 weeks on a high fat diet
    • abnormal gonadal fat pad morphology (MGI Ref ID J:122027)
      • after 11 weeks on a high fat diet, males and females have less reproductive and perirenal white adipose tissue
    • decreased percent body fat (MGI Ref ID J:122027)
      • at 8 weeks on a high fat diet, females have a lower total body fat mass that controls
    • decreased white adipose tissue amount (MGI Ref ID J:122027)
      • after 11 weeks on a high fat diet, males and females have less reproductive and perirenal white adipose tissue
  • behavior/neurological phenotype
  • hyperactivity (MGI Ref ID J:122027)
    • during light and dark phase, locomotor activity is increased at the expense of time spent in a corner
  • increased eating behavior (MGI Ref ID J:122027)
    • 28% increase in food intake
  • growth/size phenotype
  • decreased lean body mass (MGI Ref ID J:122027)
    • at 8 weeks on a high fat diet, females have a moderately lower lean body mass
  • resistance to diet-induced obesity (MGI Ref ID J:122027)
    • males and females are lean on regular chow and are resistant to high fat diet weight gain
  • nervous system phenotype
  • increased brain weight (MGI Ref ID J:122027)
  • reproductive system phenotype
  • decreased testis weight (MGI Ref ID J:122027)
  • endocrine/exocrine gland phenotype
  • decreased testis weight (MGI Ref ID J:122027)

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Adipor2tm1Dgen/Adipor2tm1Dgen

        involves: 129P2/OlaHsd * C57BL/6
  • reproductive system phenotype
  • abnormal spermatogenesis (MGI Ref ID J:101679)
    • sloughed spermatogenic precursors
  • decreased epididymis weight (MGI Ref ID J:101679)
    • low weight
  • decreased testis weight (MGI Ref ID J:101679)
    • in one of three males examined
    • low testis weight in all males tested
  • seminiferous tubule degeneration (MGI Ref ID J:101679)
    • multinucleate giant cells present in the seminiferous tubules
  • endocrine/exocrine gland phenotype
  • decreased testis weight (MGI Ref ID J:101679)
    • in one of three males examined
    • low testis weight in all males tested
  • seminiferous tubule degeneration (MGI Ref ID J:101679)
    • multinucleate giant cells present in the seminiferous tubules

Gene & Allele Details

Allele Symbol Adipor2tm1Dgen
Allele Name targeted mutation 1, Deltagen
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14
ES Cell Line Strain129P2/OlaHsd
Site of ExpressionlacZ expression is detected in: brain, spinal cord, sciatic nerve, eyes, thymus, spleen, lymph nodes, bone marrow, aorta, heart, lung, liver, pancreas, kidney, urinary bladder, thyroid gland, trachea, pituitary gland, adrenal glands, skeletal muscle, skin, testis, prostate gland, ovary, uterus and cervix; with strongest expression detected in the liver.
Gene Symbol and Name Adipor2, adiponectin receptor 2
Chromosome 6
Gene Common Name(s) 1110001I14Rik; ACDCR2; AI115388; AW554121; D6Ucla1e; DNA segment, Chr 6, University of California at Los Angeles-1, expressed; EST AI115388; FLJ21432; MGC4640; PAQR2; RIKEN cDNA 1110001I14 gene; expressed sequence AW554121;
Molecular Note A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. RNA transcripts are detectable in all tissues analyzed. LacZ expression was detected in all of the organs examined. [MGI Ref ID J:122027]

Genotyping Protocols

Adipor2tm1Dgen

Colony Maintenance

Diet Information LabDiet® 5K52/5K67

Related Strains

lacZ Expression Strains
002484   129-Alpltm1Sor/J
002292   129-Gt(ROSA)26Sor/J
006050   129-Sirt6tm1Fwa/J
003451   129-Smad3tm1Par/J
003310   129S-Gt(ROSA)26Sortm1Sor/J
003383   129S-Nogtm1Amc/J
004545   129S-Npytm1Rpa/J
005091   129S-Pnpla6tm1Blw/J
007199   129S-Sgpl1Gt(ROSA)78Sor/J
003082   129S1/SvImJ-Bcl2tm1Mpin/J
004178   B6.129(Cg)-Tg(CAG-Bgeo/GFP)21Lbe/J
004478   B6.129-Foxd1tm1Lai/J
006939   B6.129-Fut1tm1Sdo/J
005768   B6.129-Htr5atm1Dgen/J
002938   B6.129-Kdrtm1Jrt/J
004158   B6.129-Maftm1Gsb/J
006497   B6.129-Skiltm2Spw/J
005772   B6.129P2-Acvrl1tm1Dgen/J
006431   B6.129P2-Adam21tm1Dgen/J
005770   B6.129P2-Adamts4tm1Dgen/J
005771   B6.129P2-Adamts5tm1Dgen/J
005773   B6.129P2-Adcy3tm1Dgen/J
005774   B6.129P2-Adcy7tm1Dgen/J
005776   B6.129P2-Avpr1atm1Dgen/J
005777   B6.129P2-Axltm1Dgen/J
005783   B6.129P2-Cacna1ctm1Dgen/J
005780   B6.129P2-Cacna2d3tm1Dgen/J
005781   B6.129P2-Cacng3tm1Dgen/J
005782   B6.129P2-Cacng4tm1Dgen/J
005784   B6.129P2-Capn5tm1Dgen/J
005785   B6.129P2-Capn7tm1Dgen/J
005792   B6.129P2-Ccr1l1tm1Dgen/J
005793   B6.129P2-Ccr6tm1Dgen/J
005794   B6.129P2-Ccr7tm1Dgen/J
005779   B6.129P2-Celsr2tm1Dgen/J
005797   B6.129P2-Chrna2tm1Dgen/J
005787   B6.129P2-Ctsctm1Dgen/J
005796   B6.129P2-Cxcr3tm1Dgen/J
005798   B6.129P2-Drd5tm1Dgen/J
005800   B6.129P2-Efemp2tm1Dgen/J
005801   B6.129P2-Esrratm1Dgen/J
005802   B6.129P2-Faim2tm1Dgen/J
006262   B6.129P2-Fut2tm1Sdo/J
005803   B6.129P2-Fzd1tm1Dgen/J
005804   B6.129P2-Fzd8tm1Dgen/J
005811   B6.129P2-Gabra3tm1Dgen/J
005812   B6.129P2-Gabra4tm1Dgen/J
005810   B6.129P2-Gabrptm1Dgen/J
005809   B6.129P2-Galr1tm1Dgen/J
005816   B6.129P2-Glra3tm1Dgen/J
005805   B6.129P2-Gpr151tm1Dgen/J
005806   B6.129P2-Gpr37tm1Dgen/J
005807   B6.129P2-Gpr6tm1Dgen/J
005813   B6.129P2-Grik5tm1Dgen/J
005808   B6.129P2-Grk5tm1Dgen/J
005814   B6.129P2-Grm1tm1Dgen/J
005815   B6.129P2-Grm3tm1Dgen/J
005817   B6.129P2-Gsk3btm1Dgen/J
005818   B6.129P2-Hcrtr1tm1Dgen/J
005767   B6.129P2-Htr4tm1Dgen/J
005769   B6.129P2-Htr7tm1Dgen/J
005830   B6.129P2-Kcnq2tm1Dgen/J
005821   B6.129P2-Lats2tm1Dgen/J
005822   B6.129P2-Lmbr1tm1Dgen/J
005850   B6.129P2-Mapkapk2tm1Dgen/J
005824   B6.129P2-Mmp17tm1Dgen/J
005825   B6.129P2-Mtmr1tm1Dgen/J
005778   B6.129P2-Naip1tm1Dgen/J
005826   B6.129P2-Ntsr1tm1Dgen/J
005829   B6.129P2-Pkd2l2tm1Dgen/J
005828   B6.129P2-Ppardtm1Dgen/J
005831   B6.129P2-Ppm1ftm1Dgen/J
005827   B6.129P2-Ptch2tm1Dgen/J
005832   B6.129P2-Ptprotm1Dgen/J
005799   B6.129P2-S1pr4tm1Dgen/J
005837   B6.129P2-Scn11atm1Dgen/J
005836   B6.129P2-Scn9atm1Dgen/J
005834   B6.129P2-Sema5atm1Dgen/J
005835   B6.129P2-Sema6ctm1Dgen/J
006432   B6.129P2-Slc18a1tm1Dgen/J
005839   B6.129P2-Slc22a12tm1Dgen/J
005838   B6.129P2-Slc22a6tm1Dgen/J
005840   B6.129P2-Slc40a1tm1Dgen/J
005841   B6.129P2-Slc6a9tm1Dgen/J
005842   B6.129P2-Slc7a8tm1Dgen/J
005843   B6.129P2-Slc9a6tm1Dgen/J
005844   B6.129P2-Sstr1tm1Dgen/J
005847   B6.129P2-Tgfbr1tm1Dgen/J
005845   B6.129P2-Thbs4tm1Dgen/J
005790   B6.129P2-Tpp1tm1Dgen/J
005848   B6.129P2-Trpm5tm1Dgen/J
005791   B6.129P2-Xcr1tm1Dgen/J
003474   B6.129S4-Gt(ROSA)26Sortm1Sor/J
005901   B6.129S4-Ppardtm2Rev/J
006142   B6.129S4-Ppargtm1Rev/J
003754   B6.129S4-Shroom3Gt(ROSA)53Sor/J
005119   B6.129S6-Npas2tm1Slm/J
002741   B6.129S7-Alpltm1Sor/J
005970   B6.129S7-Atoh1tm2Hzo/J
006039   B6.129S7-Efnb2tm1And/J
002192   B6.129S7-Gt(ROSA)26Sor/J
005981   B6.129S7-Rai1tm1Jrl/J
005039   B6.129X1-Adra1atm1Pcs/J
005085   B6.Cg-Cd44tm1Hbg/J
007745   B6.Cg-Mirn155tm1.1Rsky/J
005317   B6.Cg-Tg(BAT-lacZ)3Picc/J
006055   B6.Cg-Tg(CAG-Bgeo,-DsRed*MST)1Nagy/J
006477   B6.Cg-Tg(CAG-lacZ-WGA)330Bbm/J
003139   B6.Cg-Tg(DBHn-lacZ)8Rpk/J
006229   B6.Cg-Tg(DRE-lacZ)2Gswz/J
002982   B6.Cg-Tg(xstpx-lacZ)32And/J
003504   B6;129-Gt(ROSA)26Sortm1Sho/J
005064   B6;129-Slc30a3tm1Rpa/J
005788   B6;129P2-Cd97tm1Dgen/J
005833   B6;129P2-Rgs4tm1Dgen/J
002073   B6;129S-Gt(ROSA)26Sor/J
006470   B6;129S-Hopxtm1Eno/J
004153   B6;129S-Mtap7Gt(ROSABetageo)1Sor/J
006958   B6;129S-Nkd1tm1Kwha/J
006960   B6;129S-Nkd2tm1Kwha/J
007204   B6;129S4-2610005L07RikGt(ROSA)73Sor/J
003309   B6;129S4-Gt(ROSA)26Sortm1Sor/J
004365   B6;129S6-Srebf1tm1Mbr/J
002317   B6;129S7-Alpltm1Sor/J
003266   B6;129S7-Epas1tm1Rus/J
006044   B6;129S7-Ephb4tm1And/J
003471   B6;C3H-Tg(CNP-GEO)1Ldh/J
006465   B6;CBA-Tg(CAG-lacZ-WGA)330Bbm/J
006680   B6;CBA-Tg(Olfr16*,taulacZ)19Mom/MomJ
006671   B6;CBA-Tg(Olfr16*,taulacZ)5Mom/MomJ
006672   B6;CBA-Tg(Olfr16*,taulacZ)7Mom/MomJ
006673   B6;CBA-Tg(Olfr16,taulacZ)sn2Mom/MomJ
004141   B6;CBA-Tg(UAS-lacZ)65Rth/J
002369   B6;SJL-Tg(c177-lacZ)226Bri/J
002372   B6;SJL-Tg(c177-lacZ)227Bri/J
002621   B6;SJL-Tg(tetop-lacZ)2Mam/J
003299   B6;SWJ-Tg(TIMP3-lacZ)7Jeb/J
002865   B6CBA-Tg(Wnt1-lacZ)206Amc/J
002955   C.129S7-Gt(ROSA)26Sor/J
002754   C57BL/6-Tg(LacZpl)60Vij/J
002193   C57BL/6J-Tg(MTn-lacZ)204Bri/J
002981   DBA/2-Tg(xstpx-lacZ)36And/J
004127   FVB-Tg(Nes-rtTA)306Rvs/J
007225   FVB.129(B6)-Usp18tm1Dzh/J
008203   FVB.Cg-Smn1tm1Msd Tg(ACTA1-SMN)63Ahmb Tg(SMN2)89Ahmb/J
008209   FVB.Cg-Smn1tm1Msd Tg(ACTA1-SMN)69Ahmb Tg(SMN2)89Ahmb/J
006214   FVB.Cg-Smn1tm1Msd/J
005024   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/J
005026   FVB.Cg-Tg(SMN2)89Ahmb Tg(SMN1*A2G)2023Ahmb Smn1tm1Msd/J
005025   FVB.Cg-Tg(SMN2*delta7)4299Ahmb Tg(SMN2)89Ahmb Smn1tm1Msd/J
003140   FVB/N-Tg(PAI1-lacZ)1Jjb/J
002856   FVB/N-Tg(TIE2-lacZ)182Sato/J
005941   FVB/N-Tg(tetO-Aurkb,lacZ)41Kra/J
003315   FVB/N-Tg(tetORo1-lacZ)3Conk/J
003487   FVB/NJ-Tg(XGFAP-lacZ)3Mes/J
005878   NOD.Cg-Cd44tm1Hbg/J
003899   STOCK Cd44tm1Hbg/J
006241   STOCK Hhiptm1Amc/J
006578   STOCK Myoz2tm1Eno/J
005707   STOCK Rag1tm1Mom Tg(TIE2-lacZ)182Sato/J
008212   STOCK Smn1tm1Msd Tg(Prnp-SMN)92Ahmb Tg(SMN2)89Ahmb/J
006882   STOCK Tg(CAG-Bgeo,-AML1/ETO,-ALPP)1Lbe/J
005438   STOCK Tg(CAG-Bgeo,-DsRed*MST)1Nagy/J
006850   STOCK Tg(CAG-Bgeo,-NOTCH1,-EGFP)1Lbe/J
006876   STOCK Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe/J
006613   STOCK Tg(CAG-Bgeo,-Tle1,-ALPP)1Lbe/J
003919   STOCK Tg(CAG-Bgeo/ALPP)1Lbe/J
003920   STOCK Tg(CAG-Bgeo/GFP)21Lbe/J
004623   STOCK Tg(Fos-lacZ)34Efu/J
006674   STOCK Tg(Olfr16,taulacZ)2030Mom/MomJ
005493   STOCK Tg(Tek-rtTA,TRE-lacZ)1425Tpr/J
002395   STOCK Tg(Zfy1-lacZ)218Bri/J
003274   STOCK Tg(tetNZL)2Bjd/J
005728   STOCK Tg(tetO-Ipf1,lacZ)958.1Macd/J
View lacZ Expression Strains     (174 strains)

Additional Web Information

Congenic Nomenclature
Fluorescent Proteins/lacZ Systems

Animal Health Reports

Room Number           AX12

Research Applications

This mouse can be used to support research in many areas including:

Research Tools
lacZ Expression

Adipor2tm1Dgen related

Cardiovascular Research

Metabolism Research

References

Additional References

Price and Supply Information

Strain Name: B6.129P2-Adipor2tm1Dgen/J
Stock Number: 005775

Price Details

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Supply Details

Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes Usually shipped between four and eight weeks of age.
This strain is included in the Induced Mutant Resource Colony collection.
LicensingSee General Terms and Conditions below for Licensing and Use Restrictions  

General Terms and Conditions

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For additional Licensing and Use Restrictions view the link(s) below:
- Strain(s) not available to companies or for-profit entities.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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