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Strain Name: |
B6.129P2-Ccr7tm1Dgen/J |
Stock Number: |
005794 |
Availability:
| Repository- Live |
Product Information
Strain Details
| Type |
JAX® GEMM® Strain -
Congenic |
| Additional information on
JAX® GEMM® Strains. |
| Type |
JAX® GEMM® Strain -
Mutant Strain |
| Type |
JAX® GEMM® Strain -
Targeted Mutation |
| Mating System | Homozygote x Homozygote
(Female x Male) |
|---|
| |
| Species | laboratory mouse |
| Generation | ?+N1F4
(31-DEC-07)
|
|
|
Strain Description
This targeted mutant was created and characterized by Deltagen, Inc. View phenotypic data developed by Deltagen.
Strain Development
The construct insert is reported to be "IRES-lacZ-Neo555T." Upon arrival at The Jackson Laboratory, these mice had been backcrossed at least 5 generations to C57BL/6 mice.
Mammalian Phenotype Terms assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Ccr7tm1Dgen/Ccr7tm1Dgen
involves: 129P2/OlaHsd * C57BL/6
- immune system phenotype
- chronic inflammation
(J:101679)
- at 49 days of age, mice exhibit patchy peribroncheolar mixed lymphocytic infiltrates
- at 49 days of age, pancreatic periductular, and to a lesser extent, peri-islet lymphocytic infiltrates
- at 49 days of age, mild to moderate predominantly lymphocytic gastric cellular infiltrates, involving one or more layers
- at 300 days of age, mild, lymphocytic infiltrates associated primarily with portal triads in the liver
|
Gene & Allele Details
| Allele Symbol |
Ccr7tm1Dgen |
| Allele Name |
targeted mutation 1, Deltagen |
| Strain of Origin | 129P2/OlaHsd |
| ES Cell Line Name | E14 |
| ES Cell Line Strain | 129P2/OlaHsd |
| Gene Symbol and Name |
Ccr7, chemokine (C-C motif) receptor 7 |
| Chromosome |
11 |
| Gene Common Name(s) |
BLR2;
CD197;
CDw197;
CMKBR7;
Cmkbr7;
EBI1;
Ebi1h;
Epstein-Barr virus induced gene 1 homolog;
MGC108519;
chemokine (C-C) receptor 7;
|
| Molecular Note |
A bacterial lacZ-neomycin fusion gene was inserted into the gene to replace a 608 bp portion of exon 3 of the gene , encoding thr-38 to glu-299, such that the endogenous gene promoter drives expression of beta-galactosidase. Beta-galactosidase expressionfrom this allele is detectable in the immune system, including the spleen and lymph nodes and in coagulating glands of the male reproductive system. [J:135850]
|
Genotyping Protocols
Ccr7tm1Dgen
Colony Maintenance
Related Strains
lacZ Expression Strains
| 002484 | 129-Alpltm1Sor/J |
| 002292 | 129-Gt(ROSA)26Sor/J |
| 006050 | 129-Sirt6tm1Fwa/J |
| 003451 | 129-Smad3tm1Par/J |
| 003310 | 129S-Gt(ROSA)26Sortm1Sor/J |
| 003383 | 129S-Nogtm1Amc/J |
| 004545 | 129S-Npytm1Rpa/J |
| 005091 | 129S-Pnpla6tm1Blw/J |
| 007199 | 129S-Sgpl1Gt(ROSA)78Sor/J |
| 003082 | 129S1/SvImJ-Bcl2tm1Mpin/J |
| 004478 | B6.129-Foxd1tm1Lai/J |
| 006939 | B6.129-Fut1tm1Sdo/J |
| 005768 | B6.129-Htr5atm1Dgen/J |
| 002938 | B6.129-Kdrtm1Jrt/J |
| 004158 | B6.129-Maftm1Gsb/J |
| 006497 | B6.129-Skiltm2Spw/J |
| 005772 | B6.129P2-Acvrl1tm1Dgen/J |
| 006431 | B6.129P2-Adam21tm1Dgen/J |
| 005770 | B6.129P2-Adamts4tm1Dgen/J |
| 005771 | B6.129P2-Adamts5tm1Dgen/J |
| 005773 | B6.129P2-Adcy3tm1Dgen/J |
| 005774 | B6.129P2-Adcy7tm1Dgen/J |
| 005775 | B6.129P2-Adipor2tm1Dgen/J |
| 005776 | B6.129P2-Avpr1atm1Dgen/J |
| 005777 | B6.129P2-Axltm1Dgen/J |
| 005783 | B6.129P2-Cacna1ctm1Dgen/J |
| 005780 | B6.129P2-Cacna2d3tm1Dgen/J |
| 005781 | B6.129P2-Cacng3tm1Dgen/J |
| 005782 | B6.129P2-Cacng4tm1Dgen/J |
| 005784 | B6.129P2-Capn5tm1Dgen/J |
| 005785 | B6.129P2-Capn7tm1Dgen/J |
| 005792 | B6.129P2-Ccr1l1tm1Dgen/J |
| 005793 | B6.129P2-Ccr6tm1Dgen/J |
| 005779 | B6.129P2-Celsr2tm1Dgen/J |
| 005797 | B6.129P2-Chrna2tm1Dgen/J |
| 005787 | B6.129P2-Ctsctm1Dgen/J |
| 005796 | B6.129P2-Cxcr3tm1Dgen/J |
| 005798 | B6.129P2-Drd5tm1Dgen/J |
| 005800 | B6.129P2-Efemp2tm1Dgen/J |
| 005801 | B6.129P2-Esrratm1Dgen/J |
| 005802 | B6.129P2-Faim2tm1Dgen/J |
| 006262 | B6.129P2-Fut2tm1Sdo/J |
| 005803 | B6.129P2-Fzd1tm1Dgen/J |
| 005804 | B6.129P2-Fzd8tm1Dgen/J |
| 005811 | B6.129P2-Gabra3tm1Dgen/J |
| 005812 | B6.129P2-Gabra4tm1Dgen/J |
| 005810 | B6.129P2-Gabrptm1Dgen/J |
| 005809 | B6.129P2-Galr1tm1Dgen/J |
| 005816 | B6.129P2-Glra3tm1Dgen/J |
| 005805 | B6.129P2-Gpr151tm1Dgen/J |
| 005806 | B6.129P2-Gpr37tm1Dgen/J |
| 005807 | B6.129P2-Gpr6tm1Dgen/J |
| 005813 | B6.129P2-Grik5tm1Dgen/J |
| 005808 | B6.129P2-Grk5tm1Dgen/J |
| 005814 | B6.129P2-Grm1tm1Dgen/J |
| 005815 | B6.129P2-Grm3tm1Dgen/J |
| 005817 | B6.129P2-Gsk3btm1Dgen/J |
| 005818 | B6.129P2-Hcrtr1tm1Dgen/J |
| 005767 | B6.129P2-Htr4tm1Dgen/J |
| 005769 | B6.129P2-Htr7tm1Dgen/J |
| 005830 | B6.129P2-Kcnq2tm1Dgen/J |
| 005821 | B6.129P2-Lats2tm1Dgen/J |
| 005822 | B6.129P2-Lmbr1tm1Dgen/J |
| 005850 | B6.129P2-Mapkapk2tm1Dgen/J |
| 005824 | B6.129P2-Mmp17tm1Dgen/J |
| 005825 | B6.129P2-Mtmr1tm1Dgen/J |
| 005778 | B6.129P2-Naip1tm1Dgen/J |
| 005826 | B6.129P2-Ntsr1tm1Dgen/J |
| 005829 | B6.129P2-Pkd2l2tm1Dgen/J |
| 005828 | B6.129P2-Ppardtm1Dgen/J |
| 005831 | B6.129P2-Ppm1ftm1Dgen/J |
| 005827 | B6.129P2-Ptch2tm1Dgen/J |
| 005832 | B6.129P2-Ptprotm1Dgen/J |
| 005799 | B6.129P2-S1pr4tm1Dgen/J |
| 005837 | B6.129P2-Scn11atm1Dgen/J |
| 005836 | B6.129P2-Scn9atm1Dgen/J |
| 005834 | B6.129P2-Sema5atm1Dgen/J |
| 005835 | B6.129P2-Sema6ctm1Dgen/J |
| 006432 | B6.129P2-Slc18a1tm1Dgen/J |
| 005839 | B6.129P2-Slc22a12tm1Dgen/J |
| 005838 | B6.129P2-Slc22a6tm1Dgen/J |
| 005840 | B6.129P2-Slc40a1tm1Dgen/J |
| 005841 | B6.129P2-Slc6a9tm1Dgen/J |
| 005842 | B6.129P2-Slc7a8tm1Dgen/J |
| 005843 | B6.129P2-Slc9a6tm1Dgen/J |
| 005844 | B6.129P2-Sstr1tm1Dgen/J |
| 005847 | B6.129P2-Tgfbr1tm1Dgen/J |
| 005845 | B6.129P2-Thbs4tm1Dgen/J |
| 005790 | B6.129P2-Tpp1tm1Dgen/J |
| 005848 | B6.129P2-Trpm5tm1Dgen/J |
| 005791 | B6.129P2-Xcr1tm1Dgen/J |
| 003474 | B6.129S4-Gt(ROSA)26Sortm1Sor/J |
| 005901 | B6.129S4-Ppardtm2Rev/J |
| 006142 | B6.129S4-Ppargtm1Rev/J |
| 003754 | B6.129S4-Shroom3Gt(ROSA)53Sor/J |
| 005119 | B6.129S6-Npas2tm1Slm/J |
| 002741 | B6.129S7-Alpltm1Sor/J |
| 005970 | B6.129S7-Atoh1tm2Hzo/J |
| 006039 | B6.129S7-Efnb2tm1And/J |
| 002192 | B6.129S7-Gt(ROSA)26Sor/J |
| 005981 | B6.129S7-Rai1tm1Jrl/J |
| 005039 | B6.129X1-Adra1atm1Pcs/J |
| 005085 | B6.Cg-Cd44tm1Hbg/J |
| 007745 | B6.Cg-Mirn155tm1.1Rsky/J |
| 005317 | B6.Cg-Tg(BAT-lacZ)3Picc/J |
| 006055 | B6.Cg-Tg(CAG-Bgeo,-DsRed*MST)1Nagy/J |
| 004178 | B6.Cg-Tg(CAG-Bgeo/GFP)21Lbe/J |
| 006477 | B6.Cg-Tg(CAG-lacZ-WGA)330Bbm/J |
| 003139 | B6.Cg-Tg(DBHn-lacZ)8Rpk/J |
| 006229 | B6.Cg-Tg(DRE-lacZ)2Gswz/J |
| 002982 | B6.Cg-Tg(xstpx-lacZ)32And/J |
| 003504 | B6;129-Gt(ROSA)26Sortm1Sho/J |
| 005064 | B6;129-Slc30a3tm1Rpa/J |
| 005788 | B6;129P2-Cd97tm1Dgen/J |
| 005833 | B6;129P2-Rgs4tm1Dgen/J |
| 002073 | B6;129S-Gt(ROSA)26Sor/J |
| 006470 | B6;129S-Hopxtm1Eno/J |
| 004153 | B6;129S-Mtap7Gt(ROSABetageo)1Sor/J |
| 006958 | B6;129S-Nkd1tm1Kwha/J |
| 006960 | B6;129S-Nkd2tm1Kwha/J |
| 007204 | B6;129S4-2610005L07RikGt(ROSA)73Sor/J |
| 003309 | B6;129S4-Gt(ROSA)26Sortm1Sor/J |
| 004365 | B6;129S6-Srebf1tm1Mbr/J |
| 002317 | B6;129S7-Alpltm1Sor/J |
| 003266 | B6;129S7-Epas1tm1Rus/J |
| 006044 | B6;129S7-Ephb4tm1And/J |
| 003471 | B6;C3H-Tg(CNP-GEO)1Ldh/J |
| 006465 | B6;CBA-Tg(CAG-lacZ-WGA)330Bbm/J |
| 006680 | B6;CBA-Tg(Olfr16*,taulacZ)19Mom/MomJ |
| 006671 | B6;CBA-Tg(Olfr16*,taulacZ)5Mom/MomJ |
| 006672 | B6;CBA-Tg(Olfr16*,taulacZ)7Mom/MomJ |
| 006673 | B6;CBA-Tg(Olfr16,taulacZ)sn2Mom/MomJ |
| 004141 | B6;CBA-Tg(UAS-lacZ)65Rth/J |
| 002369 | B6;SJL-Tg(c177-lacZ)226Bri/J |
| 002372 | B6;SJL-Tg(c177-lacZ)227Bri/J |
| 002621 | B6;SJL-Tg(tetop-lacZ)2Mam/J |
| 003299 | B6;SWJ-Tg(TIMP3-lacZ)7Jeb/J |
| 002865 | B6CBA-Tg(Wnt1-lacZ)206Amc/J |
| 002955 | C.129S7-Gt(ROSA)26Sor/J |
| 002754 | C57BL/6-Tg(LacZpl)60Vij/J |
| 002193 | C57BL/6J-Tg(MTn-lacZ)204Bri/J |
| 002981 | DBA/2-Tg(xstpx-lacZ)36And/J |
| 004127 | FVB-Tg(Nes-rtTA)306Rvs/J |
| 007225 | FVB.129(B6)-Usp18tm1Dzh/J |
| 008203 | FVB.Cg-Smn1tm1Msd Tg(ACTA1-SMN)63Ahmb Tg(SMN2)89Ahmb/J |
| 008209 | FVB.Cg-Smn1tm1Msd Tg(ACTA1-SMN)69Ahmb Tg(SMN2)89Ahmb/J |
| 006214 | FVB.Cg-Smn1tm1Msd/J |
| 005024 | FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/J |
| 005026 | FVB.Cg-Tg(SMN2)89Ahmb Tg(SMN1*A2G)2023Ahmb Smn1tm1Msd/J |
| 005025 | FVB.Cg-Tg(SMN2*delta7)4299Ahmb Tg(SMN2)89Ahmb Smn1tm1Msd/J |
| 003140 | FVB/N-Tg(PAI1-lacZ)1Jjb/J |
| 002856 | FVB/N-Tg(TIE2-lacZ)182Sato/J |
| 005941 | FVB/N-Tg(tetO-Aurkb,lacZ)41Kra/J |
| 003315 | FVB/N-Tg(tetORo1-lacZ)3Conk/J |
| 003487 | FVB/NJ-Tg(XGFAP-lacZ)3Mes/J |
| 005878 | NOD.Cg-Cd44tm1Hbg/J |
| 003899 | STOCK Cd44tm1Hbg/J |
| 006241 | STOCK Hhiptm1Amc/J |
| 006578 | STOCK Myoz2tm1Eno/J |
| 005707 | STOCK Rag1tm1Mom Tg(TIE2-lacZ)182Sato/J |
| 008212 | STOCK Smn1tm1Msd Tg(Prnp-SMN)92Ahmb Tg(SMN2)89Ahmb/J |
| 006882 | STOCK Tg(CAG-Bgeo,-AML1/ETO,-ALPP)1Lbe/J |
| 005438 | STOCK Tg(CAG-Bgeo,-DsRed*MST)1Nagy/J |
| 006850 | STOCK Tg(CAG-Bgeo,-NOTCH1,-EGFP)1Lbe/J |
| 006876 | STOCK Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe/J |
| 006613 | STOCK Tg(CAG-Bgeo,-Tle1,-ALPP)1Lbe/J |
| 003919 | STOCK Tg(CAG-Bgeo/ALPP)1Lbe/J |
| 003920 | STOCK Tg(CAG-Bgeo/GFP)21Lbe/J |
| 004623 | STOCK Tg(Fos-lacZ)34Efu/J |
| 006674 | STOCK Tg(Olfr16,taulacZ)2030Mom/MomJ |
| 005493 | STOCK Tg(Tek-rtTA,TRE-lacZ)1425Tpr/J |
| 002395 | STOCK Tg(Zfy1-lacZ)218Bri/J |
| 003274 | STOCK Tg(tetNZL)2Bjd/J |
| 005728 | STOCK Tg(tetO-Ipf1,lacZ)958.1Macd/J |
View lacZ Expression Strains (174 strains)
Strains carrying other alleles of Ccr7
View Strains carrying other alleles of Ccr7 (1 strain)
Additional Web Information
Congenic Nomenclature
Fluorescent Proteins/lacZ Systems
Animal Health Reports
Room Number AX12
Research Applications
This mouse can be used to support research in many areas including:
Research Tools
lacZ Expression
Ccr7tm1Dgen related
Immunology and Inflammation Research
References
Additional References
Price and Supply Information
| Strain Name: |
B6.129P2-Ccr7tm1Dgen/J |
| Stock Number: |
005794 |
Price Details
IMPORTANT NOTE: Prices are based on shipping destination.
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
| Supply Notes |
Usually shipped between four and eight weeks of age.
This strain is included in the Induced Mutant Resource Colony collection.
|
| Licensing | See General Terms and Conditions below
for Licensing and Use Restrictions
|
General Terms and Conditions
View
JAX® Mice & Services Conditions of Use.
For additional Licensing and Use Restrictions view the link(s) below:
- Strain(s) not available to companies or for-profit entities.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene
genotyping programs to ensure the genetic background of JAX
® Mice strains as
well as the genotypes of strains with identified molecular mutations.
JAX
® Mice strains are only made available to researchers after meeting our
standards. However, the phenotype of each strain may not be fully
characterized and/or captured in the strain data sheets.
Therefore, we
cannot guarantee a strain's phenotype will meet all expectations. To
ensure that JAX
® Mice will meet the needs of individual research projects
or when requesting a strain that is new to your research, we suggest ordering
and performing tests on a small number of mice to determine suitability for
your particular project.
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