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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Congenic; Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Hemizygote (Female x Male) 16-APR-07 Species laboratory mouse Generation ?+N2F4 (31-DEC-08)
Generation DefinitionsDescription
This targeted mutant was created and characterized by Deltagen, Inc. View phenotypic data developed by Deltagen.Development
The construct insert is reported to be "SA-IRES-lacZ-Neo555G/Kan." Upon arrival at The Jackson Laboratory, the donating investigator stated that these mice had been backcrossed at least 6 generations to C57BL/6 mice (see SNP note below).A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, 1 of 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to The Jackson Laboratory Repository were on a mixed C57BL/6J ; C57BL/6N genetic background.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
lacZ Expression Strains
View lacZ Expression Strains (245 strains)
Additional Web Information
Fluorescent Proteins/lacZ Systems
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Cxcr3tm1Dgen/Y
involves: 129P2/OlaHsd * C57BL/6
- homeostasis/metabolism phenotype
- increased circulating glucose level
- elevated serum glucose levels in male hemizygous mice (MGI Ref ID J:101679)
This mouse can be used to support research in many areas including:
Immunology and Inflammation Research
Research Tools
lacZ Expression
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Cxcr3tm1Dgen | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Deltagen | ||
| Allele Type | Targeted (Reporter) | ||
| Strain of Origin | 129P2/OlaHsd | ||
| ES Cell Line Name | E14 | ||
| ES Cell Line Strain | 129P2/OlaHsd | ||
| Site of Expression | Faint lacZ expression is detected in some regions of wholemount brain. | ||
| Expressed Gene | lacZ, beta-galactosidase, E. coli | ||
| Molecular Note | A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. RT-PCR analysis detects a high level of gene transcript in spleen, lymph nodes and ovary, moderate levels in cerebellum, lung, liver, pancreas, kidney, thymus, bone marrow, skin, gallbladder, urinary bladder, pituitary gland, adrenal gland, salivary gland, colon, epididymis, seminal vesicle, coagulating gland, uterus and white fat, and low levels in whole brain, cortex, subcortical region, brainstem, olfactory bulb, spinal cord, eye, Harderian glands, heart, skeletal muscle, tongue, stomach, small intestine, cecum, testis and prostate gland. However, faint beta-galactosidase expression from this allele is detectable in onlyin whole mount brain. | ||
| Gene Symbol and Name | Cxcr3, chemokine (C-X-C motif) receptor 3 | ||
| Chromosome | X | ||
| Gene Common Name(s) | CD182; CD183; CKR-L2; CMKAR3; Cmkar3; GPR9; IP10-R; Mig-R; MigR; chemokine (C-X-C) receptor 3; | ||
Genotyping
Genotyping Information
Genotyping Protocols
Cxcr3tm1Dgen, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Additional References
Cxcr3tm1Dgen relatedCuenca AG; Wynn JL; Kelly-Scumpia KM; Scumpia PO; Vila L; Delano MJ; Mathews CE; Wallet SM; Reeves WH; Behrns KE; Nacionales DC; Efron PA; Kunkel SL; Moldawer LL. 2011. Critical Role for CXC Ligand 10/CXC Receptor 3 Signaling in the Murine Neonatal Response to Sepsis. Infect Immun 79(7):2746-54. [PubMed: 21518789] [MGI Ref ID J:173484]
Deltagen Inc. 2005. NIH initiative supporting placement of Deltagen, Inc. mice into public repositories MGI Direct Data Submission :. [MGI Ref ID J:101679]
Koch MA; Tucker-Heard G; Perdue NR; Killebrew JR; Urdahl KB; Campbell DJ. 2009. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol 10(6):595-602. [PubMed: 19412181] [MGI Ref ID J:149556]
Kroetz DN; Deepe GS Jr. 2011. An aberrant thymus in CCR5-/- mice is coupled with an enhanced adaptive immune response in fungal infection. J Immunol 186(10):5949-55. [PubMed: 21478401] [MGI Ref ID J:173093]
Sorensen EW; Gerber SA; Frelinger JG; Lord EM. 2010. IL-12 suppresses vascular endothelial growth factor receptor 3 expression on tumor vessels by two distinct IFN-gamma-dependent mechanisms. J Immunol 184(4):1858-66. [PubMed: 20061409] [MGI Ref ID J:159492]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Mating System Homozygote x Hemizygote (Female x Male) 16-APR-07 Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Live Mice
Price (US dollars $) Gender Genotypes Provided Individual Mouse $138.00 Male Hemizygous for Cxcr3tm1Dgen $138.00 Female Homozygous for Cxcr3tm1Dgen
Pairs /Price (US dollars $) Pair Genotype $276.00 Homozygous for Cxcr3tm1Dgen x Hemizygous for Cxcr3tm1Dgen Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
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Live Mice
Price (US dollars $) Gender Genotypes Provided Individual Mouse $179.40 Male Hemizygous for Cxcr3tm1Dgen $179.40 Female Homozygous for Cxcr3tm1Dgen
Pairs /Price (US dollars $) Pair Genotype $358.80 Homozygous for Cxcr3tm1Dgen x Hemizygous for Cxcr3tm1Dgen Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
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Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
General Supply Notes
- This strain is included in the Induced Mutant Resource Colony collection.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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