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Genes & Alleles

Gpr6;   Gpr6tm1Dgen;

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Product Information

Strain Details

Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Type JAX® GEMM® Strain - Targeted Mutation Species laboratory mouse

Strain Description
This targeted mutant was created and characterized by Deltagen, Inc. View phenotypic data developed by Deltagen.

Strain Development
The construct insert is reported to be "Lac0-SA-IRES-lacZ-Neo555G/Kan." Upon arrival, these mice had been backcrossed four generations to C57BL/6. During the importation process at The Jackson Laboratory, at least one additional backcross to C57BL/6J mice was performed. The resulting mice are backcrossed a total of at least five generations.

Mammalian Phenotype Terms assigned by genotype Gpr6tm1Dgen/Gpr6tm1Dgen         B6.129P2-Gpr6tm1Dgen behavior/neurological phenotype abnormal conditioning behavior (MGI Ref ID J:126659) instrumental-conditioning is reduced compared to in wild type mice that acquire the bar-pressing response to obtain food faster and reach higher asymptotic performance after more extensive training however, sensitivity to devaluation in instrumental conditioning remains normal and appetite motivated response to auditory cued conditioning is normal mice are more sensitive to devaluation than wild type mice in an auditory cued conditioning experiment under a progressive ratio 5 schedule, mice respond at higher rates and earn more food reward than wild type mice and in omission testing mice continue to press the level compared to wild type mice that stop nervous system phenotype abnormal striatum morphology (MGI Ref ID J:126659) plasma membrane extracts from the striatum contain 55% less cAMP that in wild type mice however, forskolin-induced camp production is normal The following phenotype information may relate to a genetic background differing from this JAX® Mice strain. Gpr6tm1Dgen/Gpr6tm1Dgen         involves: 129P2/OlaHsd * C57BL/6 normal phenotype no abnormal phenotype detected (MGI Ref ID J:101679) no significant differences in physical examinations, necropsy including body length, body weight, and organ weight measurements, histological examination of tissues and organs, bone marrow section evaluations, complete blood counts and differentials, clinical chemistry panels, densitometry or behavioral tests detected in the homozygous mutant mice when compared with age- and gender-matched wild-type control mice

Gene & Allele Details

Allele Symbol		Gpr6tm1Dgen
Allele Name		targeted mutation 1, Deltagen
Strain of Origin		129P2/OlaHsd
ES Cell Line Name		E14
ES Cell Line Strain		129P2/OlaHsd
Site of Expression		lacZ expression mimics endogenous gene expression and is detected in the brain, eyes and pituitary gland.
Gene Symbol and Name		Gpr6, G protein-coupled receptor 6
Chromosome		10
Gene Common Name(s)		AI852874; Gm233; expressed sequence AI852874; gene model 233, (NCBI);
Molecular Note		A bacterial lacZ gene was inserted into the gene such that the endogenous gene promoter drives expression of beta-galactosidase. RT-PCR analysis detects a high level of gene transcript in the whole brain, cortex, subcortical region, pancreas, pituitary gland and adrenal gland, moderate levels in cerebellum, olfactory bulb, eye, heart, liver, thymus, lymph nodes, skin, salivary gland, large intestine and prostate gland and low levels in kidney, spleen, testis and seminal vesicle. Beta-galactosidase expression from this allele is detectable in brain, eyes and pituitary gland. Strong expression was detected in several regions of the brain, including the caudate putamen, cortex, thalamus and hippocampus. Moderate expression was detected in some cells in the inner nuclear layer of the retina. In the pituitary gland, moderate staining was observed in many cells of the pars intermedia. [MGI Ref ID J:101679]

Control Information

	Control
	Wild-type from the colony
Considerations for Choosing Controls

Related Strains

lacZ Expression Strains

002484	129-Alpltm1Sor/J
002292	129-Gt(ROSA)26Sor/J
006050	129-Sirt6tm1Fwa/J
003451	129-Smad3tm1Par/J
003310	129S-Gt(ROSA)26Sortm1Sor/J
003383	129S-Nogtm1Amc/J
004545	129S-Npytm1Rpa/J
005091	129S-Pnpla6tm1Blw/J
007199	129S-Sgpl1Gt(ROSA)78Sor/J
003082	129S1/SvImJ-Bcl2tm1Mpin/J
004178	B6.129(Cg)-Tg(CAG-Bgeo/GFP)21Lbe/J
004478	B6.129-Foxd1tm1Lai/J
006939	B6.129-Fut1tm1Sdo/J
005768	B6.129-Htr5atm1Dgen/J
002938	B6.129-Kdrtm1Jrt/J
004158	B6.129-Maftm1Gsb/J
006497	B6.129-Skiltm2Spw/J
005772	B6.129P2-Acvrl1tm1Dgen/J
006431	B6.129P2-Adam21tm1Dgen/J
005770	B6.129P2-Adamts4tm1Dgen/J
005771	B6.129P2-Adamts5tm1Dgen/J
005773	B6.129P2-Adcy3tm1Dgen/J
005774	B6.129P2-Adcy7tm1Dgen/J
005775	B6.129P2-Adipor2tm1Dgen/J
005776	B6.129P2-Avpr1atm1Dgen/J
005777	B6.129P2-Axltm1Dgen/J
005783	B6.129P2-Cacna1ctm1Dgen/J
005780	B6.129P2-Cacna2d3tm1Dgen/J
005781	B6.129P2-Cacng3tm1Dgen/J
005782	B6.129P2-Cacng4tm1Dgen/J
005784	B6.129P2-Capn5tm1Dgen/J
005785	B6.129P2-Capn7tm1Dgen/J
005792	B6.129P2-Ccr1l1tm1Dgen/J
005793	B6.129P2-Ccr6tm1Dgen/J
005794	B6.129P2-Ccr7tm1Dgen/J
005779	B6.129P2-Celsr2tm1Dgen/J
005797	B6.129P2-Chrna2tm1Dgen/J
005787	B6.129P2-Ctsctm1Dgen/J
005796	B6.129P2-Cxcr3tm1Dgen/J
005798	B6.129P2-Drd5tm1Dgen/J
005800	B6.129P2-Efemp2tm1Dgen/J
005801	B6.129P2-Esrratm1Dgen/J
005802	B6.129P2-Faim2tm1Dgen/J
005803	B6.129P2-Fzd1tm1Dgen/J
005804	B6.129P2-Fzd8tm1Dgen/J
005811	B6.129P2-Gabra3tm1Dgen/J
005812	B6.129P2-Gabra4tm1Dgen/J
005810	B6.129P2-Gabrptm1Dgen/J
005809	B6.129P2-Galr1tm1Dgen/J
005816	B6.129P2-Glra3tm1Dgen/J
005805	B6.129P2-Gpr151tm1Dgen/J
005806	B6.129P2-Gpr37tm1Dgen/J
005813	B6.129P2-Grik5tm1Dgen/J
005808	B6.129P2-Grk5tm1Dgen/J
005814	B6.129P2-Grm1tm1Dgen/J
005815	B6.129P2-Grm3tm1Dgen/J
005817	B6.129P2-Gsk3btm1Dgen/J
005818	B6.129P2-Hcrtr1tm1Dgen/J
005767	B6.129P2-Htr4tm1Dgen/J
005769	B6.129P2-Htr7tm1Dgen/J
005830	B6.129P2-Kcnq2tm1Dgen/J
005821	B6.129P2-Lats2tm1Dgen/J
005822	B6.129P2-Lmbr1tm1Dgen/J
005850	B6.129P2-Mapkapk2tm1Dgen/J
005824	B6.129P2-Mmp17tm1Dgen/J
005825	B6.129P2-Mtmr1tm1Dgen/J
005778	B6.129P2-Naip1tm1Dgen/J
005826	B6.129P2-Ntsr1tm1Dgen/J
005829	B6.129P2-Pkd2l2tm1Dgen/J
005828	B6.129P2-Ppardtm1Dgen/J
005831	B6.129P2-Ppm1ftm1Dgen/J
005827	B6.129P2-Ptch2tm1Dgen/J
005832	B6.129P2-Ptprotm1Dgen/J
005799	B6.129P2-S1pr4tm1Dgen/J
005837	B6.129P2-Scn11atm1Dgen/J
005836	B6.129P2-Scn9atm1Dgen/J
005834	B6.129P2-Sema5atm1Dgen/J
005835	B6.129P2-Sema6ctm1Dgen/J
006432	B6.129P2-Slc18a1tm1Dgen/J
005839	B6.129P2-Slc22a12tm1Dgen/J
005838	B6.129P2-Slc22a6tm1Dgen/J
005840	B6.129P2-Slc40a1tm1Dgen/J
005841	B6.129P2-Slc6a9tm1Dgen/J
005842	B6.129P2-Slc7a8tm1Dgen/J
005843	B6.129P2-Slc9a6tm1Dgen/J
005844	B6.129P2-Sstr1tm1Dgen/J
005847	B6.129P2-Tgfbr1tm1Dgen/J
005845	B6.129P2-Thbs4tm1Dgen/J
005790	B6.129P2-Tpp1tm1Dgen/J
005848	B6.129P2-Trpm5tm1Dgen/J
005791	B6.129P2-Xcr1tm1Dgen/J
003474	B6.129S4-Gt(ROSA)26Sortm1Sor/J
005901	B6.129S4-Ppardtm2Rev/J
006142	B6.129S4-Ppargtm1Rev/J
003754	B6.129S4-Shroom3Gt(ROSA)53Sor/J
005119	B6.129S6-Npas2tm1Slm/J
002741	B6.129S7-Alpltm1Sor/J
005970	B6.129S7-Atoh1tm2Hzo/J
006039	B6.129S7-Efnb2tm1And/J
002192	B6.129S7-Gt(ROSA)26Sor/J
005981	B6.129S7-Rai1tm1Jrl/J
005039	B6.129X1-Adra1atm1Pcs/J
006262	B6.129X1-Fut2tm1Sdo/J
005085	B6.Cg-Cd44tm1Hbg/J
007745	B6.Cg-Mirn155tm1.1Rsky/J
005317	B6.Cg-Tg(BAT-lacZ)3Picc/J
006055	B6.Cg-Tg(CAG-Bgeo,-DsRed*MST)1Nagy/J
006477	B6.Cg-Tg(CAG-lacZ-WGA)330Bbm/J
003139	B6.Cg-Tg(DBHn-lacZ)8Rpk/J
006229	B6.Cg-Tg(DRE-lacZ)2Gswz/J
002982	B6.Cg-Tg(xstpx-lacZ)32And/J
003504	B6;129-Gt(ROSA)26Sortm1Sho/J
005064	B6;129-Slc30a3tm1Rpa/J
005788	B6;129P2-Cd97tm1Dgen/J
005833	B6;129P2-Rgs4tm1Dgen/J
002073	B6;129S-Gt(ROSA)26Sor/J
006470	B6;129S-Hopxtm1Eno/J
004153	B6;129S-Mtap7Gt(ROSABetageo)1Sor/J
006958	B6;129S-Nkd1tm1Kwha/J
006960	B6;129S-Nkd2tm1Kwha/J
007204	B6;129S4-2610005L07RikGt(ROSA)73Sor/J
003309	B6;129S4-Gt(ROSA)26Sortm1Sor/J
004365	B6;129S6-Srebf1tm1Mbr/J
002317	B6;129S7-Alpltm1Sor/J
003266	B6;129S7-Epas1tm1Rus/J
006044	B6;129S7-Ephb4tm1And/J
003471	B6;C3H-Tg(CNP-GEO)1Ldh/J
006465	B6;CBA-Tg(CAG-lacZ-WGA)330Bbm/J
006680	B6;CBA-Tg(Olfr16*,taulacZ)19Mom/MomJ
006671	B6;CBA-Tg(Olfr16*,taulacZ)5Mom/MomJ
006672	B6;CBA-Tg(Olfr16*,taulacZ)7Mom/MomJ
006673	B6;CBA-Tg(Olfr16,taulacZ)sn2Mom/MomJ
004141	B6;CBA-Tg(UAS-lacZ)65Rth/J
002369	B6;SJL-Tg(c177-lacZ)226Bri/J
002372	B6;SJL-Tg(c177-lacZ)227Bri/J
002621	B6;SJL-Tg(tetop-lacZ)2Mam/J
003299	B6;SWJ-Tg(TIMP3-lacZ)7Jeb/J
002865	B6CBA-Tg(Wnt1-lacZ)206Amc/J
002955	C.129S7-Gt(ROSA)26Sor/J
002754	C57BL/6-Tg(LacZpl)60Vij/J
002193	C57BL/6J-Tg(MTn-lacZ)204Bri/J
002981	DBA/2-Tg(xstpx-lacZ)36And/J
004127	FVB-Tg(Nes-rtTA)306Rvs/J
007225	FVB.129(B6)-Usp18tm1Dzh/J
008203	FVB.Cg-Smn1tm1Msd Tg(ACTA1-SMN)63Ahmb Tg(SMN2)89Ahmb/J
008209	FVB.Cg-Smn1tm1Msd Tg(ACTA1-SMN)69Ahmb Tg(SMN2)89Ahmb/J
006214	FVB.Cg-Smn1tm1Msd/J
005024	FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/J
005026	FVB.Cg-Tg(SMN2)89Ahmb Tg(SMN1*A2G)2023Ahmb Smn1tm1Msd/J
005025	FVB.Cg-Tg(SMN2*delta7)4299Ahmb Tg(SMN2)89Ahmb Smn1tm1Msd/J
003140	FVB/N-Tg(PAI1-lacZ)1Jjb/J
002856	FVB/N-Tg(TIE2-lacZ)182Sato/J
005941	FVB/N-Tg(tetO-Aurkb,lacZ)41Kra/J
003315	FVB/N-Tg(tetORo1-lacZ)3Conk/J
003487	FVB/NJ-Tg(XGFAP-lacZ)3Mes/J
005878	NOD.Cg-Cd44tm1Hbg/J
003899	STOCK Cd44tm1Hbg/J
006241	STOCK Hhiptm1Amc/J
006578	STOCK Myoz2tm1Eno/J
005707	STOCK Rag1tm1Mom Tg(TIE2-lacZ)182Sato/J
008212	STOCK Smn1tm1Msd Tg(Prnp-SMN)92Ahmb Tg(SMN2)89Ahmb/J
006882	STOCK Tg(CAG-Bgeo,-AML1/ETO,-ALPP)1Lbe/J
005438	STOCK Tg(CAG-Bgeo,-DsRed*MST)1Nagy/J
006850	STOCK Tg(CAG-Bgeo,-NOTCH1,-EGFP)1Lbe/J
006876	STOCK Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe/J
006613	STOCK Tg(CAG-Bgeo,-Tle1,-ALPP)1Lbe/J
003919	STOCK Tg(CAG-Bgeo/ALPP)1Lbe/J
003920	STOCK Tg(CAG-Bgeo/GFP)21Lbe/J
004623	STOCK Tg(Fos-lacZ)34Efu/J
006674	STOCK Tg(Olfr16,taulacZ)2030Mom/MomJ
005493	STOCK Tg(Tek-rtTA,TRE-lacZ)1425Tpr/J
002395	STOCK Tg(Zfy1-lacZ)218Bri/J
003274	STOCK Tg(tetNZL)2Bjd/J
005728	STOCK Tg(tetO-Ipf1,lacZ)958.1Macd/J

View lacZ Expression Strains     (174 strains)

Additional Web Information

Congenic Nomenclature
Fluorescent Proteins/lacZ Systems

Research Applications

This mouse can be used to support research in many areas including:

Neurobiology Research
Receptor Defects (G protein-coupled receptor)

Research Tools
lacZ Expression

Gpr6^tm1Dgen related

Neurobiology Research

References

Additional References

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Price and Supply Information

Strain Name:	B6.129P2-Gpr6tm1Dgen/J
Stock Number:	005807

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Supply Details

Standard Supply	Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes	Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services: Tel: 1-800-422-6423 or 1-207-288-5845; Email: jaxservices@jax.org. This strain is included in the Induced Mutant Resource Colony collection.
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Control Information	View Control Information in Strain Details.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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