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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Type Congenic; Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Generation ?+N1p (22-JAN-06)
Generation DefinitionsDescription
This targeted mutant was created and characterized by Deltagen, Inc. View phenotypic data developed by Deltagen.Development
The construct insert is reported to be "SA-IRES-lacZ-Neo555G/Kan." Upon arrival at The Jackson Laboratory, these mice had been backcrossed at least 5 generations to C57BL/6 mice.
Related Strains
lacZ Expression Strains
View lacZ Expression Strains (245 strains)
Additional Web Information
Fluorescent Proteins/lacZ Systems
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Scn11atm1Dgen/Scn11a+
involves: 129P2/OlaHsd * C57BL/6
- behavior/neurological phenotype
- abnormal nociception after inflammation
- after treatment with formalin, heterozygous mice display decreased pain-related behavior during the late phase (10-45 minutes after injection) and thermal hyperalgesia is less prolonged after treatment with complete Freund's adjuvant (MGI Ref ID J:99870)
- integument phenotype
- abnormal nociception after inflammation
- after treatment with formalin, heterozygous mice display decreased pain-related behavior during the late phase (10-45 minutes after injection) and thermal hyperalgesia is less prolonged after treatment with complete Freund's adjuvant (MGI Ref ID J:99870)
Scn11atm1Dgen/Scn11atm1Dgen
involves: 129P2/OlaHsd * C57BL/6
- behavior/neurological phenotype
- abnormal nociception after inflammation
- after treatment with formalin, homozygous mice display decreased pain-related behavior during the late phase (10-45 minutes after injection), thermal hyperalgesia is less prolonged after treatment with carrageenan or complete Freund's adjuvant and absent after treatment with PGE2 (MGI Ref ID J:99870)
- homozygous mice display length, weight, blood chemistry, fertility, lifespan, and thermal and mechanical nociception similar to wild-type (MGI Ref ID J:99870)
- integument phenotype
- abnormal nociception after inflammation
- after treatment with formalin, homozygous mice display decreased pain-related behavior during the late phase (10-45 minutes after injection), thermal hyperalgesia is less prolonged after treatment with carrageenan or complete Freund's adjuvant and absent after treatment with PGE2 (MGI Ref ID J:99870)
- homozygous mice display length, weight, blood chemistry, fertility, lifespan, and thermal and mechanical nociception similar to wild-type (MGI Ref ID J:99870)
This mouse can be used to support research in many areas including:
Scn11atm1Dgen relatedNeurobiology Research
Channel and Transporter Defects
sodium
Research Tools
lacZ Expression
Neurobiology Research
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Scn11atm1Dgen | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Deltagen | ||
| Allele Type | Targeted (knock-out) | ||
| Common Name(s) | Nav1.9-; SCN11A-; | ||
| Strain of Origin | 129P2/OlaHsd | ||
| ES Cell Line Name | E14 | ||
| ES Cell Line Strain | 129P2/OlaHsd | ||
| Site of Expression | lacZ expression it is not detected in any tissue or organs examined. | ||
| Expressed Gene | lacZ, beta-galactosidase, E. coli | ||
| Molecular Note | An IRES-lacZ-neo cassette was inserted to replace 174 bp encompassing exon 3 and parts of exons 2 and 4, and encoding the first and second membrane-spanning segments of domain I. While RT-PCR analysis detects a gene transcript in most tissues analyzed, beta-galactosidase expression from this allele is not detectable in any tissues or organs. [MGI Ref ID J:99870] | ||
| Gene Symbol and Name | Scn11a, sodium channel, voltage-gated, type XI, alpha | ||
| Chromosome | 9 | ||
| Gene Common Name(s) | NAV1.9; NSS2; NaN; NaT; SCN12A; SNS-2; SNS2; | ||
Genotyping
Genotyping Information
Genotyping Protocols
Scn11atm1Dgen, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Additional References
Scn11atm1Dgen relatedDeltagen Inc. 2005. NIH initiative supporting placement of Deltagen, Inc. mice into public repositories MGI Direct Data Submission :. [MGI Ref ID J:101679]
Padilla F; Couble ML; Coste B; Maingret F; Clerc N; Crest M; Ritter AM; Magloire H; Delmas P. 2007. Expression and localization of the Nav1.9 sodium channel in enteric neurons and in trigeminal sensory endings: implication for intestinal reflex function and orofacial pain. Mol Cell Neurosci 35(1):138-52. [PubMed: 17363266] [MGI Ref ID J:123231]
Priest BT; Murphy BA; Lindia JA; Diaz C; Abbadie C; Ritter AM; Liberator P; Iyer LM; Kash SF; Kohler MG; Kaczorowski GJ; MacIntyre DE; Martin WJ. 2005. Contribution of the tetrodotoxin-resistant voltage-gated sodium channel NaV1.9 to sensory transmission and nociceptive behavior. Proc Natl Acad Sci U S A 102(26):9382-7. [PubMed: 15964986] [MGI Ref ID J:99870]
Ritter AM; Martin WJ; Thorneloe KS. 2009. The voltage-gated sodium channel Nav1.9 is required for inflammation-based urinary bladder dysfunction. Neurosci Lett 452(1):28-32. [PubMed: 19146922] [MGI Ref ID J:146535]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, RG10/RG30.
Purchasing information
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $1980.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
- Cryorecovery - Standard.
We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2574.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
- Cryorecovery - Standard.
We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
General Supply Notes
- This strain is included in the Induced Mutant Resource Colony collection.
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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For Licensing and Use Restrictions view the link(s) below:
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Contact information
General inquiriesContracts Administration
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| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
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