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Strain Name:

B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/J

Stock Number:

005864

Availability:

Repository- Live


Link to main datasheet for 005864

Additional References

 

Burgess BL; McIsaac SA; Naus KE; Chan JY; Tansley GH; Yang J; Miao F; Ross CJ; van Eck M; Hayden MR; van Nostrand W; St George-Hyslop P; Westaway D; Wellington CL. 2006. Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer's disease mouse models with abundant A beta in plasma. Neurobiol Dis 24(1):114-27. [PubMed: 16899370]  [MGI Ref ID J:113199]

Butovsky O; Kunis G; Koronyo-Hamaoui M; Schwartz M. 2007. Selective ablation of bone marrow-derived dendritic cells increases amyloid plaques in a mouse Alzheimer's disease model. Eur J Neurosci 26(2):413-6. [PubMed: 17623022]  [MGI Ref ID J:127277]

Cao D; Lu H; Lewis TL; Li L. 2007. Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease. J Biol Chem 282(50):36275-82. [PubMed: 17942401]  [MGI Ref ID J:129021]

Choi SH; Leight SN; Lee VM; Li T; Wong PC; Johnson JA; Saraiva MJ; Sisodia SS. 2007. Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin). J Neurosci 27(26):7006-10. [PubMed: 17596449]  [MGI Ref ID J:122976]

Garcia-Alloza M; Borrelli LA; Rozkalne A; Hyman BT; Bacskai BJ. 2007. Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model J Neurochem 102(4):1095-104. [PubMed: 17472706]  [MGI Ref ID J:120785]

Garcia-Alloza M; Robbins EM; Zhang-Nunes SX; Prucell SM; Betensky RA; Raju S; Prada C; Greenberg SM; Bacskai BJ; Frosch MP. 2006. Charaterization of amyloid deposition in the APPswe/PS2dE9 mouse model of Alzheimer disease Neurobiol Dis 24(3):516-524. [PubMed: 17029828]  [MGI Ref ID J:113200]

Goto Y; Niidome T; Hongo H; Akaike A; Kihara T; Sugimoto H. 2008. Impaired muscarinic regulation of excitatory synaptic transmission in the APPswe/PS1dE9 mouse model of Alzheimer's disease. Eur J Pharmacol 583(1):84-91. [PubMed: 18282567]  [MGI Ref ID J:134791]

Hirsch-Reinshagen V; Chan JY; Wilkinson A; Tanaka T; Fan J; Ou G; Maia LF; Singaraja RR; Hayden MR; Wellington CL. 2007. Physiologically regulated transgenic ABCA1 does not reduce amyloid burden or amyloid-beta peptide levels in vivo. J Lipid Res 48(4):914-23. [PubMed: 17235115]  [MGI Ref ID J:121674]

Hirsch-Reinshagen V; Maia LF; Burgess BL; Blain JF; Naus KE; McIsaac SA; Parkinson PF; Chan JY; Tansley GH; Hayden MR; Poirier J; Van Nostrand W; Wellington CL. 2005. The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease. J Biol Chem 280(52):43243-56. [PubMed: 16207707]  [MGI Ref ID J:105900]

Hooijmans CR; Graven C; Dederen PJ; Tanila H; van Groen T; Kiliaan AJ. 2007. Amyloid beta deposition is related to decreased glucose transporter-1 levels and hippocampal atrophy in brains of aged APP/PS1 mice. Brain Res 1181:93-103. [PubMed: 17916337]  [MGI Ref ID J:127348]

Hooijmans CR; Rutters F; Dederen PJ; Gambarota G; Veltien A; van Groen T; Broersen LM; Lutjohann D; Heerschap A; Tanila H; Kiliaan AJ. 2007. Changes in cerebral blood volume and amyloid pathology in aged Alzheimer APP/PS1 mice on a docosahexaenoic acid (DHA) diet or cholesterol enriched Typical Western Diet (TWD). Neurobiol Dis 28(1):16-29. [PubMed: 17720508]  [MGI Ref ID J:134833]

Jankowsky JL; Slunt HH; Ratovitski T; Jenkins NA; Copeland NG; Borchelt DR. 2001. Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. Biomol Eng 17(6):157-65. [PubMed: 11337275]  [MGI Ref ID J:78664]

Jankowsky JL; Younkin LH; Gonzales V; Fadale DJ; Slunt HH; Lester HA; Younkin SG; Borchelt DR. 2007. Rodent A beta modulates the solubility and distribution of amyloid deposits in transgenic mice. J Biol Chem 282(31):22707-20. [PubMed: 17556372]  [MGI Ref ID J:124804]

Lalonde R; Kim HD; Fukuchi K. 2004. Exploratory activity, anxiety, and motor coordination in bigenic APPswe + PS1/DeltaE9 mice. Neurosci Lett 369(2):156-61. [PubMed: 15450687]  [MGI Ref ID J:93096]

Lalonde R; Kim HD; Maxwell JA; Fukuchi K. 2005. Exploratory activity and spatial learning in 12-month-old APP(695)SWE/co+PS1/DeltaE9 mice with amyloid plaques. Neurosci Lett 390(2):87-92. [PubMed: 16169151]  [MGI Ref ID J:104569]

Li T; Wen H; Brayton C; Laird FM; Ma G; Peng S; Placanica L; Wu TC; Crain BJ; Price DL; Eberhart CG; Wong PC. 2007. Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities. J Neurosci 27(40):10849-59. [PubMed: 17913918]  [MGI Ref ID J:125592]

Liang X; Wang Q; Hand T; Wu L; Breyer RM; Montine TJ; Andreasson K. 2005. Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease. J Neurosci 25(44):10180-7. [PubMed: 16267225]  [MGI Ref ID J:102728]

Machova E; Jakubik J; Michal P; Oksman M; Iivonen H; Tanila H; Dolezal V. 2008. Impairment of muscarinic transmission in transgenic APPswe/PS1dE9 mice. Neurobiol Aging 29(3):368-78. [PubMed: 17140703]  [MGI Ref ID J:135055]

Malm TM; Iivonen H; Goldsteins G; Keksa-Goldsteine V; Ahtoniemi T; Kanninen K; Salminen A; Auriola S; Van Groen T; Tanila H; Koistinaho J. 2007. Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden. J Neurosci 27(14):3712-21. [PubMed: 17409235]  [MGI Ref ID J:119404]

Melnikova T; Savonenko A; Wang Q; Liang X; Hand T; Wu L; Kaufmann WE; Vehmas A; Andreasson KI. 2006. Cycloxygenase-2 activity promotes cognitive deficits but not increased amyloid burden in a model of Alzheimer's disease in a sex-dimorphic pattern. Neuroscience 141(3):1149-62. [PubMed: 16753269]  [MGI Ref ID J:111748]

Meyer-Luehmann M; Spires-Jones TL; Prada C; Garcia-Alloza M; de Calignon A; Rozkalne A; Koenigsknecht-Talboo J; Holtzman DM; Bacskai BJ; Hyman BT. 2008. Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease. Nature 451(7179):720-4. [PubMed: 18256671]  [MGI Ref ID J:132628]

Minkeviciene R; Ihalainen J; Malm T; Matilainen O; Keksa-Goldsteine V; Goldsteins G; Iivonen H; Leguit N; Glennon J; Koistinaho J; Banerjee P; Tanila H. 2008. Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice. J Neurochem 105(3):584-94. [PubMed: 18042177]  [MGI Ref ID J:134481]

Ni Y; Zhao X; Bao G; Zou L; Teng L; Wang Z; Song M; Xiong J; Bai Y; Pei G. 2006. Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation. Nat Med 12(12):1390-6. [PubMed: 17115048]  [MGI Ref ID J:117739]

O'Neil JN; Mouton PR; Tizabi Y; Ottinger MA; Lei DL; Ingram DK; Manaye KF. 2007. Catecholaminergic neuronal loss in locus coeruleus of aged female dtg APP/PS1 mice. J Chem Neuroanat 34(3-4):102-7. [PubMed: 17658239]  [MGI Ref ID J:129903]

Park JH; Gimbel DA; GrandPre T; Lee JK; Kim JE; Li W; Lee DH; Strittmatter SM. 2006. Alzheimer precursor protein interaction with the Nogo-66 receptor reduces amyloid-beta plaque deposition. J Neurosci 26(5):1386-95. [PubMed: 16452662]  [MGI Ref ID J:105196]

Park JH; Widi GA; Gimbel DA; Harel NY; Lee DH; Strittmatter SM. 2006. Subcutaneous Nogo receptor removes brain amyloid-beta and improves spatial memory in Alzheimer's transgenic mice. J Neurosci 26(51):13279-86. [PubMed: 17182778]  [MGI Ref ID J:116775]

Reiserer RS; Harrison FE; Syverud DC; McDonald MP. 2007. Impaired spatial learning in the APP + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease. Genes Brain Behav 6(1):54-65. [PubMed: 17233641]  [MGI Ref ID J:116798]

Shaftel SS; Kyrkanides S; Olschowka JA; Miller JN; Johnson RE; O'Banion MK. 2007. Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology. J Clin Invest 117(6):1595-604. [PubMed: 17549256]  [MGI Ref ID J:122022]

Shemer I; Holmgren C; Min R; Fulop L; Zilberter M; Sousa KM; Farkas T; Hartig W; Penke B; Burnashev N; Tanila H; Zilberter Y; Harkany T. 2006. Non-fibrillar beta-amyloid abates spike-timing-dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting postsynaptic AMPA receptors. Eur J Neurosci 23(8):2035-47. [PubMed: 16630051]  [MGI Ref ID J:108064]

Sheng JG; Price DL; Koliatsos VE. 2002. Disruption of corticocortical connections ameliorates amyloid burden in terminal fields in a transgenic model of Abeta amyloidosis. J Neurosci 22(22):9794-9. [PubMed: 12427835]  [MGI Ref ID J:134697]

Stoltenberg M; Bush AI; Bach G; Smidt K; Larsen A; Rungby J; Lund S; Doering P; Danscher G. 2007. Amyloid plaques arise from zinc-enriched cortical layers in APP/PS1 transgenic mice and are paradoxically enlarged with dietary zinc deficiency. Neuroscience 150(2):357-69. [PubMed: 17949919]  [MGI Ref ID J:130788]

Zelcer N; Khanlou N; Clare R; Jiang Q; Reed-Geaghan EG; Landreth GE; Vinters HV; Tontonoz P. 2007. Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors. Proc Natl Acad Sci U S A 104(25):10601-6. [PubMed: 17563384]  [MGI Ref ID J:122372]

 

Link to main datasheet for 005864

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