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| This strain is now distributed by the Mutant Mouse Regional Resource Center. Please refer to the Mutant Mouse Regional Resource Center (MMRRC) for ordering information and strain details on B6.Cg-Tg(APP695)3Dbo Tg(PSEN1dE9)S9Dbo/Mmjax
MMRRC Stock Number 034833. As a designated MMRRC center, The Jackson Laboratory will continue to distribute these mice at the same high health and quality standards but ordering is exclusively provided through the MMRRC. | ||||||||||||||||||||||
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- Disease & phenotype
- Genes & alleles
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Description
Strain Information
Former Names B6.Cg-Tg(APP695)3Dbo Tg(PSEN1dE9)S9Dbo/J (Changed: 10-AUG-11 ) Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Donating Investigator Dr. David R. Borchelt, McKnight Brain Inst, Univ of Florida Description
Double transgenic mice are viable and fertile. At 6 months of age, double-transgenic mice show visible amyloid plaque deposition but are indistinguishable from nontransgenic animals in all cognitive measures. By 18 months, amyloid deposits were much higher in APPswe/PS1dE9 mice with statistically significant but mild decreases in cholinergic markers (cortex and hippocampus) and somatostatin levels (cortex). Performance of older double-transgenic mice is impaired in all cognitive tasks, and deficits in episodic-like memory tasks correlate with total amyloid-beta peptide loads in the brain. Mutant mice, hemizygous for each transgene, and on the C57BL/6J background (N6), have altered EEG (decreased cortical theta activity and increased beta and gamma activity). EEG differences are detected as early as 7 month of age (Wang et al. Brain Res 2002).Development
Mutant amyloid precursor protein (APPswe) transgenic mice (line C3-3) express a chimeric mouse/human APP-695 with mutations linked to familial Alzheimers disease (KM 593/594 NL). The C3-3 line was backcrossed to C57BL/6J mice for 10 generations. Presenilin 1 (PSEN1) transgenic mice (line S-9) express human PSEN1 carrying the exon-9-deleted variant (PSEN1dE9) associated with familial Alzheimer's disease. Originally created on a hybrid strain background (C3H/HeJ;C57BL/6J), the S-9 line was backcrossed to C57BL/6J for six generations. Both are under the control of the mouse prion protein (PrP) promoter, directing transgene expression predominantly to CNS neurons. APPswe/PS1dE9 double transgenic mice were produced by mating APP-695 line C3-3 males to PS1dE9 line S-9 females, and then backcrossing double transgenic males to C57BL/6J mice for 10 generations before arriving at the MMRRC at The Jackson Laboratory.
Related Strains
Alzheimer's Disease Models
View Alzheimer's Disease Models (108 strains)
003378 B6C3-Tg(APP695)3Dbo Tg(PSEN1)5Dbo/J 003375 C3B6-Tg(APP695)3Dbo/Mmjax
005864 B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax 004462 B6C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax 003627 B6C3-Tg(HD82Gln)81Dbo/J
Additional Web Information
Visit the Alzheimer's Disease Mouse Model Resource site for helpful information on Alzheimer's Disease and research resources.
Phenotype
Phenotype Information
- Characteristics of this human disease are associated with transgenes and other mutation types in the mouse.
Alzheimer Disease 3
Alzheimer Disease 4
Alzheimer Disease; AD
- Potential model based on transgenic expression of an ortholog of a human gene that is associated with this disease. Phenotypic similarity to the human disease has not been tested. Acne Inversa, Familial, 3; ACNINV3 (PSEN1)
Cardiomyopathy, Dilated, 1u; CMD1U (PSEN1)
Frontotemporal Dementia; FTD (PSEN1)
Pick Disease of Brain (PSEN1)
assigned by genotype
Tg(APP695)3Dbo/0 Tg(PSEN1dE9)S9Dbo/0
B6.Cg-Tg(APP695)3Dbo Tg(PSEN1dE9)S9Dbo/Mmjax
- nervous system phenotype
- amyloid beta deposits (MGI Ref ID J:157228)
- other phenotype
- amyloid beta deposits (MGI Ref ID J:157228)
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Tg(APP695)3Dbo/0 Tg(PSEN1dE9)S9Dbo/0
involves: C3H/HeJ * C57BL/6J
- nervous system phenotype
- amyloid beta deposits
- at 7 months of age, mice exhibit amyloid plaques in the hippocampus and cortex (MGI Ref ID J:104236)
- develops diffuse, compact, birefringent congophilic plaques in cortex and hippocampus (MGI Ref ID J:87691)
- ratio of amyloid beta peptide 40:42 is 0.75:1 (MGI Ref ID J:87691)
- 150% increase in amyloid beta peptide 42 (MGI Ref ID J:87691)
- other phenotype
- amyloid beta deposits
- at 7 months of age, mice exhibit amyloid plaques in the hippocampus and cortex (MGI Ref ID J:104236)
- develops diffuse, compact, birefringent congophilic plaques in cortex and hippocampus (MGI Ref ID J:87691)
- ratio of amyloid beta peptide 40:42 is 0.75:1 (MGI Ref ID J:87691)
- 150% increase in amyloid beta peptide 42 (MGI Ref ID J:87691)
Tg(APP695)3Dbo/0 Tg(PSEN1dE9)S9Dbo/0
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J
- behavior/neurological phenotype
- *normal* behavior/neurological phenotype (MGI Ref ID J:123534)
- abnormal spatial learning
- mice travel shorter distance in open-field and show less activity or excursions into central area; mice remain near periphery of apparatus rather than entering open center of field (MGI Ref ID J:123534)
- abnormal spatial reference memory
- 16-18 month-old mice swim farther to find platform and spend less time in platform vicinity than controls (MGI Ref ID J:123534)
- nervous system phenotype
- amyloid beta deposits
- one month following neuron injection with virus expressing short hairpin RNA to silence Bace1, there is a 38% reduction in amyloid beta burden in hippocampus compared to uninjected hippocampus (MGI Ref ID J:123534)
- other phenotype
- amyloidosis
- mice display amyloid beta aggregates at 12 and 20 months (MGI Ref ID J:123534)
- amyloid beta deposits
- one month following neuron injection with virus expressing short hairpin RNA to silence Bace1, there is a 38% reduction in amyloid beta burden in hippocampus compared to uninjected hippocampus (MGI Ref ID J:123534)
Tg(APP695)3Dbo/0 Tg(PSEN1dE9)S9Dbo/0
Background Not Specified
- nervous system phenotype
- abnormal amacrine cell morphology
- distribution of amacrine cell processes is disrupted as determined by syntaxin 1 staining (MGI Ref ID J:139070)
- abnormal microglial cell morphology
- increase in microglial cell activity in retina is observed in 12-15 month old transgenics (MGI Ref ID J:139070)
- microglia processes in the retina are thicker and display a dendritic-like appearance as compared to control (MGI Ref ID J:139070)
- microglia density, but not cell body size, is increased in transgenics (MGI Ref ID J:139070)
- amyloid beta deposits
- thioflavine-S positive plaques are observed in the retina beginning at 12 months of age (MGI Ref ID J:139070)
- plaques have radial branches with a central core (MGI Ref ID J:139070)
- plaque size ranges from 5-20 um, larger plaques are observed at 15-16 months (MGI Ref ID J:139070)
- plaques appear earlier in females than in males and increase in number over time (MGI Ref ID J:139070)
- 100% of females and 75% of males have plaques in retina by 15-16 months (MGI Ref ID J:139070)
- vision/eye phenotype
- abnormal eye electrophysiology
- abnormal retina morphology
- thioflavine-S positive plaques are observed in the retina beginning at 12 months of age (MGI Ref ID J:139070)
- most plaques (34.7% and 41% respectively) are found in the inner and outer plexiform layers (MGI Ref ID J:139070)
- thickness of the retinal nuclear layers is similar to control, suggesting that there is no obvious neuronal cell loss (MGI Ref ID J:139070)
- abnormal amacrine cell morphology
- distribution of amacrine cell processes is disrupted as determined by syntaxin 1 staining (MGI Ref ID J:139070)
- abnormal retinal inner plexiform layer morphology
- abnormal retinal outer plexiform layer morphology
- immune system phenotype
- abnormal microglial cell morphology
- increase in microglial cell activity in retina is observed in 12-15 month old transgenics (MGI Ref ID J:139070)
- microglia processes in the retina are thicker and display a dendritic-like appearance as compared to control (MGI Ref ID J:139070)
- microglia density, but not cell body size, is increased in transgenics (MGI Ref ID J:139070)
- other phenotype
- amyloid beta deposits
- thioflavine-S positive plaques are observed in the retina beginning at 12 months of age (MGI Ref ID J:139070)
- plaques have radial branches with a central core (MGI Ref ID J:139070)
- plaque size ranges from 5-20 um, larger plaques are observed at 15-16 months (MGI Ref ID J:139070)
- plaques appear earlier in females than in males and increase in number over time (MGI Ref ID J:139070)
- 100% of females and 75% of males have plaques in retina by 15-16 months (MGI Ref ID J:139070)
- hematopoietic system phenotype
- abnormal microglial cell morphology
- increase in microglial cell activity in retina is observed in 12-15 month old transgenics (MGI Ref ID J:139070)
- microglia processes in the retina are thicker and display a dendritic-like appearance as compared to control (MGI Ref ID J:139070)
- microglia density, but not cell body size, is increased in transgenics (MGI Ref ID J:139070)
This mouse can be used to support research in many areas including:
Tg(APP695)3Dbo relatedNeurobiology Research
Alzheimer's Disease
APP and PSEN1 mutants
Presenilin mutants
strains expressing mutant APP
Behavioral and Learning Defects
Mouse/Human Gene Homologs
Alzheimer's
Neurobiology Research
Alzheimer's Disease
Neurodegeneration
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(APP695)3Dbo | ||
|---|---|---|---|
| Allele Name | transgene insertion 3, David R Borchelt | ||
| Allele Type | Transgenic (random, expressed) | ||
| Common Name(s) | APP695; APP695swe; APPswe; Mo/HuAPPswe; line C3-3; | ||
| Mutation Made By | Dr. David Borchelt, McKnight Brain Inst, Univ of Florida | ||
| Strain of Origin | (C57BL/6J x C3H/HeJ)F2 | ||
| Expressed Gene | APP695, amyloid beta (A4) precursor protein (chimeric), mouse/human chimera | ||
| Promoter | Prn, prion protein gene complex, mouse, laboratory | ||
| General Note |
Three transgenic lines were generated and designated by the authors lines Q2-2, E1-2 (Tg(Prnp-App/APPswe)E1-2Dbo) and C3-3. This line was generated from founder number C3-3. Transgenic mice develop amyloid deposits in brain tissue by 18-20 months of age. Transgenic mice that are also transgenic for Tg(PSEN1)5Dboexpress both human presenilin 1 (A246E variant) and a chimeric amyloid precursor protein (APPSwe) under direction of the mouse prion protein promoter. Elevated levels of the AB1-42(43) peptide are detected in brain homogenates. By nine months of age, histological examination of brain tissue from these mice reveals numerous amyloid deposits resembling those observed in the brains of patients with Alzheimer's disease (AD). The number of amyloid deposits increases dramatically between the ages of 10 and 12 months. | ||
| Molecular Note | The transgene is composed of a cDNA encoding a chimeric APP protein regulated by the mouse prion promoter. The chimeric APP molecule was created by replacing sequences encoding the Abeta domain of a 695 amino acid isoform of the murine sequence with the cognate sequences of the human gene (mutations K595N, M596L). The human mutations are found in familial Alzheimer's disease. Transgene expression was observed in the brain and heart by Western blot analysis using a monoclonal antibody recognizing the human Abeta region. [MGI Ref ID J:80782] | ||
| Allele Symbol | Tg(PSEN1dE9)S9Dbo | ||
| Allele Name | transgene insertion S9, David R Borchelt | ||
| Allele Type | Transgenic (random, expressed) | ||
| Common Name(s) | PS1 deltaE9; PS1 transgene (line S-9); PS1-deltaE9; PS1dE9 transgene; PS1deltaE9 (line S-9); deltaE9; huPS1deltaE9; line S-9; | ||
| Mutation Made By | Dr. David Borchelt, McKnight Brain Inst, Univ of Florida | ||
| Strain of Origin | (C57BL/6J x C3H/HeJ)F2 | ||
| Expressed Gene | PSEN1, presenilin 1, human | ||
| Promoter | Prnp, prion protein, mouse, laboratory | ||
| General Note |
The deltaE9 PSEN1 protein variant fails to undergo endoproteolysis in cultured lymphoblasts from an affected human carrier and instead accumulates as the full-length, 40 kDa mutant protein (J:34323). Similarly, immunoblotting of of cortical and hippocampal extracts from transgenic mice under conditions that distinguish mouse and human full-length PSEN1 and their endoproteolytic derivatives demonstrates failure of the transgenic protein to undergo endoproteolysis. (J:104147) The amount of full-length mutant human PSEN1 in brains of deltaE9 PSEN1 transgenic mice exceeds by ~60% the cumulative amount of the full-length human PSEN1 and its N-terminal derivative in brains of transgenic mice expressing wild-type human PSEN1. (J:104147) | ||
| Molecular Note | The coding sequence of the transgene is derived from the cDNA of the familial Alzheimer disease- (FAD-) associated deltaE9 variant of human presenilin 1, which has a splice acceptor mutation upstream of exon 9 that results in a protein lacking amino acids 290-319. The mutant cDNA replaces the coding region of the mouse prion protein (Prp) gene in a construct that contains ~6 kb of genomic DNA upstream of the primary PRP translation start site and includes the noncoding first exon and first intron and, following the inserted PSEN1 sequence, ~3 kb of 3' untranslated sequence; this construct has been shown to drive expression in both neurons and glial cells of the central nervous system (CNS). [MGI Ref ID J:104147] [MGI Ref ID J:34323] [MGI Ref ID J:80782] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Human PSEN1 cDNA Multiplex1, Melt Curve Analysis
Generic Mouse App cDNA Multiplex1, Melt Curve Analysis
Generic Tg(APP), Standard PCR
Tg(PSEN1), Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Savonenko A; Xu GM; Melnikova T; Morton JL; Gonzales V; Wong MP; Price DL; Tang F; Markowska AL; Borchelt DR. 2005. Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships to beta-amyloid deposition and neurotransmitter abnormalities. Neurobiol Dis 18(3):602-17. [PubMed: 15755686] [MGI Ref ID J:104236]
Additional References
Verret L; Jankowsky JL; Xu GM; Borchelt DR; Rampon C. 2007. Alzheimer's-type amyloidosis in transgenic mice impairs survival of newborn neurons derived from adult hippocampal neurogenesis. J Neurosci 27(25):6771-80. [PubMed: 17581964] [MGI Ref ID J:122001]
Tg(APP695)3Dbo relatedTg(PSEN1dE9)S9Dbo relatedBailey AR; Hou H; Obregon DF; Tian J; Zhu Y; Zou Q; Nikolic WV; Bengtson M; Mori T; Murphy T; Tan J. 2012. Aberrant T-lymphocyte development and function in mice overexpressing human soluble amyloid precursor protein-alpha: implications for autism. FASEB J 26(3):1040-51. [PubMed: 22085641] [MGI Ref ID J:182808]
Boissonneault V; Plante I; Rivest S; Provost P. 2009. MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1. J Biol Chem 284(4):1971-81. [PubMed: 18986979] [MGI Ref ID J:146980]
Borchelt DR; Davis J; Fischer M; Lee MK; Slunt HH; Ratovitsky T; Regard J; Copeland NG; Jenkins NA; Sisodia SS; Price DL. 1996. A vector for expressing foreign genes in the brains and hearts of transgenic mice. Genet Anal 13(6):159-63. [PubMed: 9117892] [MGI Ref ID J:80782]
Borchelt DR; Ratovitski T; van Lare J; Lee MK; Gonzales V; Jenkins NA; Copeland NG; Price DL; Sisodia SS. 1997. Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron 19(4):939-45. [PubMed: 9354339] [MGI Ref ID J:43788]
Borchelt DR; Thinakaran G; Eckman CB; Lee MK; Davenport F; Ratovitsky T; Prada CM; Kim G; Seekins S; Yager D; Slunt HH; Wang R; Seeger M; Levey AI; Gandy SE; Copeland NG; Jenkins NA; Price DL; Younkin SG; Sisodia SS. 1996. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron 17(5):1005-13. [PubMed: 8938131] [MGI Ref ID J:80882]
Cai D; Zhong M; Wang R; Netzer WJ; Shields D; Zheng H; Sisodia SS; Foster DA; Gorelick FS; Xu H; Greengard P. 2006. Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons. Proc Natl Acad Sci U S A 103(6):1936-40. [PubMed: 16449385] [MGI Ref ID J:106075]
Cai Y; Xue ZQ; Zhang XM; Li MB; Wang H; Luo XG; Cai H; Yan XX. 2012. An age-related axon terminal pathology around the first olfactory relay that involves amyloidogenic protein overexpression without plaque formation. Neuroscience 215:160-73. [PubMed: 22542680] [MGI Ref ID J:192436]
Dodson SE; Andersen OM; Karmali V; Fritz JJ; Cheng D; Peng J; Levey AI; Willnow TE; Lah JJ. 2008. Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's disease. J Neurosci 28(48):12877-86. [PubMed: 19036982] [MGI Ref ID J:142501]
El-Amouri SS; Zhu H; Yu J; Marr R; Verma IM; Kindy MS. 2008. Neprilysin: an enzyme candidate to slow the progression of Alzheimer's disease. Am J Pathol 172(5):1342-54. [PubMed: 18403590] [MGI Ref ID J:134308]
Filali M; Lalonde R. 2009. Age-related cognitive decline and nesting behavior in an APPswe/PS1 bigenic model of Alzheimer's disease. Brain Res 1292:93-9. [PubMed: 19643098] [MGI Ref ID J:157207]
Filali M; Lalonde R; Rivest S. 2008. Cognitive and non-cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer's disease. Genes Brain Behav 8(2):143-8. [PubMed: 19077180] [MGI Ref ID J:142183]
Filali M; Lalonde R; Rivest S. 2011. Subchronic memantine administration on spatial learning, exploratory activity, and nest-building in an APP/PS1 mouse model of Alzheimer's disease. Neuropharmacology 60(6):930-6. [PubMed: 21281652] [MGI Ref ID J:178504]
Garcia-Alloza M; Dodwell SA; Meyer-Luehmann M; Hyman BT; Bacskai BJ. 2006. Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model. J Neuropathol Exp Neurol 65(11):1082-9. [PubMed: 17086105] [MGI Ref ID J:120918]
Gureviciene I; Ikonen S; Gurevicius K; Sarkaki A; van Groen T; Pussinen R; Ylinen A; Tanila H. 2004. Normal induction but accelerated decay of LTP in APP + PS1 transgenic mice. Neurobiol Dis 15(2):188-95. [PubMed: 15006688] [MGI Ref ID J:128772]
Helft J; Manicassamy B; Guermonprez P; Hashimoto D; Silvin A; Agudo J; Brown BD; Schmolke M; Miller JC; Leboeuf M; Murphy KM; Garcia-Sastre A; Merad M. 2012. Cross-presenting CD103+ dendritic cells are protected from influenza virus infection. J Clin Invest 122(11):4037-47. [PubMed: 23041628] [MGI Ref ID J:193561]
Huang HJ; Liang KC; Ke HC; Chang YY; Hsieh-Li HM. 2011. Long-term social isolation exacerbates the impairment of spatial working memory in APP/PS1 transgenic mice. Brain Res 1371:150-60. [PubMed: 21114967] [MGI Ref ID J:170247]
Iivonen H; Nurminen L; Harri M; Tanila H; Puolivali J. 2003. Hypothermia in mice tested in Morris water maze. Behav Brain Res 141(2):207-13. [PubMed: 12742257] [MGI Ref ID J:130974]
Jankowsky JL; Fadale DJ; Anderson J; Xu GM; Gonzales V; Jenkins NA; Copeland NG; Lee MK; Younkin LH; Wagner SL; Younkin SG; Borchelt DR. 2004. Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Hum Mol Genet 13(2):159-70. [PubMed: 14645205] [MGI Ref ID J:87691]
Jankowsky JL; Melnikova T; Fadale DJ; Xu GM; Slunt HH; Gonzales V; Younkin LH; Younkin SG; Borchelt DR; Savonenko AV. 2005. Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease. J Neurosci 25(21):5217-24. [PubMed: 15917461] [MGI Ref ID J:98541]
Jankowsky JL; Slunt HH; Gonzales V; Jenkins NA; Copeland NG; Borchelt DR. 2004. APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1. Neurobiol Aging 25(7):885-92. [PubMed: 15212842] [MGI Ref ID J:102351]
Kalesnykas G; Roschier U; Puolivali J; Wang J; Miettinen R. 2005. The effect of aging on the subcellular distribution of estrogen receptor-alpha in the cholinergic neurons of transgenic and wild-type mice. Eur J Neurosci 21(5):1437-42. [PubMed: 15813954] [MGI Ref ID J:101077]
Kanekiyo T; Liu CC; Shinohara M; Li J; Bu G. 2012. LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-beta. J Neurosci 32(46):16458-65. [PubMed: 23152628] [MGI Ref ID J:192453]
Ke HC; Huang HJ; Liang KC; Hsieh-Li HM. 2011. Selective improvement of cognitive function in adult and aged APP/PS1 transgenic mice by continuous non-shock treadmill exercise. Brain Res 1403:1-11. [PubMed: 21689809] [MGI Ref ID J:174067]
Laird FM; Cai H; Savonenko AV; Farah MH; He K; Melnikova T; Wen H; Chiang HC; Xu G; Koliatsos VE; Borchelt DR; Price DL; Lee HK; Wong PC. 2005. BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. J Neurosci 25(50):11693-709. [PubMed: 16354928] [MGI Ref ID J:123534]
Lazarov O; Morfini GA; Pigino G; Gadadhar A; Chen X; Robinson J; Ho H; Brady ST; Sisodia SS. 2007. Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1. J Neurosci 27(26):7011-20. [PubMed: 17596450] [MGI Ref ID J:122975]
Lee GD; Aruna JH; Barrett PM; Lei DL; Ingram DK; Mouton PR. 2005. Stereological analysis of microvascular parameters in a double transgenic model of Alzheimer's disease. Brain Res Bull 65(4):317-22. [PubMed: 15811597] [MGI Ref ID J:135436]
Lesuisse C; Xu G; Anderson J; Wong M; Jankowsky J; Holtz G; Gonzalez V; Wong PC; Price DL; Tang F; Wagner S; Borchelt DR. 2001. Hyper-expression of human apolipoprotein E4 in astroglia and neurons does not enhance amyloid deposition in transgenic mice. Hum Mol Genet 10(22):2525-37. [PubMed: 11709540] [MGI Ref ID J:72987]
Li G; Zou L; Jack CR Jr; Yang Y; Yang ES. 2007. Neuroprotective effect of Coenzyme Q10 on ischemic hemisphere in aged mice with mutations in the amyloid precursor protein. Neurobiol Aging 28(6):877-82. [PubMed: 16806588] [MGI Ref ID J:121939]
Li L; Zhang X; Yang D; Luo G; Chen S; Le W. 2009. Hypoxia increases Abeta generation by altering beta- and gamma-cleavage of APP. Neurobiol Aging 30(7):1091-8. [PubMed: 18063223] [MGI Ref ID J:152965]
Liang C; Zhu H; Xu Y; Huang L; Ma C; Deng W; Liu Y; Qin C. 2012. MicroRNA-153 negatively regulates the expression of amyloid precursor protein and amyloid precursor-like protein 2. Brain Res 1455:103-13. [PubMed: 22510281] [MGI Ref ID J:186457]
Liu L; Ikonen S; Heikkinen T; Heikkila M; Puolivali J; van Groen T; Tanila H. 2002. Effects of fimbria-fornix lesion and amyloid pathology on spatial learning and memory in transgenic APP+PS1 mice. Behav Brain Res 134(1-2):433-45. [PubMed: 12191831] [MGI Ref ID J:129807]
Liu L; Tapiola T; Herukka SK; Heikkila M; Tanila H. 2003. Abeta levels in serum, CSF and brain, and cognitive deficits in APP + PS1 transgenic mice. Neuroreport 14(1):163-6. [PubMed: 12544850] [MGI Ref ID J:89843]
Liu Y; Yoo MJ; Savonenko A; Stirling W; Price DL; Borchelt DR; Mamounas L; Lyons WE; Blue ME; Lee MK. 2008. Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease. J Neurosci 28(51):13805-14. [PubMed: 19091971] [MGI Ref ID J:143521]
Lopez JR; Lyckman A; Oddo S; Laferla FM; Querfurth HW; Shtifman A. 2008. Increased intraneuronal resting [Ca2+] in adult Alzheimer's disease mice. J Neurochem 105(1):262-71. [PubMed: 18021291] [MGI Ref ID J:141555]
Manczak M; Reddy PH. 2012. Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage. Hum Mol Genet 21(11):2538-47. [PubMed: 22367970] [MGI Ref ID J:183771]
Melnikova T; Savonenko A; Wang Q; Liang X; Hand T; Wu L; Kaufmann WE; Vehmas A; Andreasson KI. 2006. Cycloxygenase-2 activity promotes cognitive deficits but not increased amyloid burden in a model of Alzheimer's disease in a sex-dimorphic pattern. Neuroscience 141(3):1149-62. [PubMed: 16753269] [MGI Ref ID J:111748]
Montgomery KS; Simmons RK; Edwards G 3rd; Nicolle MM; Gluck MA; Myers CE; Bizon JL. 2011. Novel age-dependent learning deficits in a mouse model of Alzheimer's disease: Implications for translational research. Neurobiol Aging 32(7):1273-85. [PubMed: 19720431] [MGI Ref ID J:173732]
Naert G; Rivest S. 2011. CC Chemokine Receptor 2 Deficiency Aggravates Cognitive Impairments and Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease. J Neurosci 31(16):6208-20. [PubMed: 21508244] [MGI Ref ID J:171601]
Nikolajsen GN; Jensen MS; West MJ. 2011. Cholinergic axon length reduced by 300 meters in the brain of an Alzheimer mouse model. Neurobiol Aging 32(11):1927-31. [PubMed: 21752495] [MGI Ref ID J:176689]
Oh ES; Savonenko AV; King JF; Fangmark Tucker SM; Rudow GL; Xu G; Borchelt DR; Troncoso JC. 2009. Amyloid precursor protein increases cortical neuron size in transgenic mice. Neurobiol Aging 30(8):1238-44. [PubMed: 18304698] [MGI Ref ID J:152955]
Ojala J; Alafuzoff I; Herukka SK; van Groen T; Tanila H; Pirttila T. 2009. Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients. Neurobiol Aging 30(2):198-209. [PubMed: 17658666] [MGI Ref ID J:145816]
Perez SE; Dar S; Ikonomovic MD; DeKosky ST; Mufson EJ. 2007. Cholinergic forebrain degeneration in the APPswe/PS1DeltaE9 transgenic mouse. Neurobiol Dis 28(1):3-15. [PubMed: 17662610] [MGI Ref ID J:134818]
Perez SE; Lazarov O; Koprich JB; Chen EY; Rodriguez-Menendez V; Lipton JW; Sisodia SS; Mufson EJ. 2005. Nigrostriatal dysfunction in familial Alzheimer's disease-linked APPswe/PS1DeltaE9 transgenic mice. J Neurosci 25(44):10220-9. [PubMed: 16267229] [MGI Ref ID J:102362]
Perez SE; Lumayag S; Kovacs B; Mufson EJ; Xu S. 2008. {beta}-Amyloid Deposition and Functional Impairment in the Retina of the APPswe/PS1{Delta}E9 Transgenic Mouse Model of Alzheimer's Disease. Invest Ophthalmol Vis Sci 50(2):793-800. [PubMed: 18791173] [MGI Ref ID J:139070]
Pistell PJ; Zhu M; Ingram DK. 2008. Acquisition of conditioned taste aversion is impaired in the amyloid precursor protein/presenilin 1 mouse model of Alzheimer's disease. Neuroscience 152(3):594-600. [PubMed: 18304749] [MGI Ref ID J:135640]
Popovic M; Caballero-Bleda M; Kadish I; Van Groen T. 2008. Subfield and layer-specific depletion in calbindin-D28K, calretinin and parvalbumin immunoreactivity in the dentate gyrus of amyloid precursor protein/presenilin 1 transgenic mice. Neuroscience 155(1):182-91. [PubMed: 18583063] [MGI Ref ID J:140778]
Richard KL; Filali M; Prefontaine P; Rivest S. 2008. Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease. J Neurosci 28(22):5784-93. [PubMed: 18509040] [MGI Ref ID J:136387]
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Rodriguez JJ; Olabarria M; Chvatal A; Verkhratsky A. 2009. Astroglia in dementia and Alzheimer's disease. Cell Death Differ 16(3):378-85. [PubMed: 19057621] [MGI Ref ID J:158080]
Savonenko AV; Xu GM; Price DL; Borchelt DR; Markowska AL. 2003. Normal cognitive behavior in two distinct congenic lines of transgenic mice hyperexpressing mutant APP SWE. Neurobiol Dis 12(3):194-211. [PubMed: 12742740] [MGI Ref ID J:109847]
Simard AR; Soulet D; Gowing G; Julien JP; Rivest S. 2006. Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron 49(4):489-502. [PubMed: 16476660] [MGI Ref ID J:107605]
Simpson RJ. 1992. Effect of hypoxic exposure on iron absorption in heterozygous hypotransferrinaemic mice. Ann Hematol 65(6):260-4. [PubMed: 1457587] [MGI Ref ID J:12201]
Soderman A; Mikkelsen JD; West MJ; Christensen DZ; Jensen MS. 2011. Activation of nicotinic alpha(7) acetylcholine receptor enhances long term potentation in wild type mice but not in APP(swe)/PS1DeltaE9 mice. Neurosci Lett 487(3):325-9. [PubMed: 20974225] [MGI Ref ID J:168638]
Soderman A; Thomsen MS; Hansen HH; Nielsen EO; Jensen MS; West MJ; Mikkelsen JD. 2008. The nicotinic alpha7 acetylcholine receptor agonist ssr180711 is unable to activate limbic neurons in mice overexpressing human amyloid-beta1-42. Brain Res 1227:240-7. [PubMed: 18619425] [MGI Ref ID J:139987]
Son SM; Jung ES; Shin HJ; Byun J; Mook-Jung I. 2012. Abeta-induced formation of autophagosomes is mediated by RAGE-CaMKKbeta-AMPK signaling. Neurobiol Aging 33(5):1006.e11-23. [PubMed: 22048125] [MGI Ref ID J:188183]
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Szapacs ME; Numis AL; Andrews AM. 2004. Late onset loss of hippocampal 5-HT and NE is accompanied by increases in BDNF protein expression in mice co-expressing mutant APP and PS1. Neurobiol Dis 16(3):572-80. [PubMed: 15262269] [MGI Ref ID J:131666]
Tang J; Song M; Wang Y; Fan X; Xu H; Bai Y. 2009. Noggin and BMP4 co-modulate adult hippocampal neurogenesis in the APP(swe)/PS1(DeltaE9) transgenic mouse model of Alzheimer's disease. Biochem Biophys Res Commun 385(3):341-5. [PubMed: 19463786] [MGI Ref ID J:150675]
Turdi S; Guo R; Huff AF; Wolf EM; Culver B; Ren J. 2009. Cardiomyocyte contractile dysfunction in the APPswe/PS1dE9 mouse model of Alzheimer's disease. PLoS One 4(6):e6033. [PubMed: 19551139] [MGI Ref ID J:150191]
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Wang CM; Devries S; Camboni M; Glass M; Martin PT. 2010. Immunization with the SDPM1 peptide lowers amyloid plaque burden and improves cognitive function in the APPswePSEN1(A246E) transgenic mouse model of Alzheimer's disease. Neurobiol Dis 39(3):409-22. [PubMed: 20493257] [MGI Ref ID J:163033]
Wang J; Ikonen S; Gurevicius K; Van Groen T; Tanila H. 2003. Altered auditory-evoked potentials in mice carrying mutated human amyloid precursor protein and presenilin-1 transgenes. Neuroscience 116(2):511-7. [PubMed: 12559106] [MGI Ref ID J:128594]
Wang J; Ikonen S; Gurevicius K; van Groen T; Tanila H. 2002. Alteration of cortical EEG in mice carrying mutated human APP transgene. Brain Res 943(2):181-90. [PubMed: 12101040] [MGI Ref ID J:78111]
Wang J; Tanila H; Puolivali J; Kadish I; van Groen T. 2003. Gender differences in the amount and deposition of amyloidbeta in APPswe and PS1 double transgenic mice. Neurobiol Dis 14(3):318-27. [PubMed: 14678749] [MGI Ref ID J:100956]
Wang X; Liu P; Zhu H; Xu Y; Ma C; Dai X; Huang L; Liu Y; Zhang L; Qin C. 2009. miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation. Brain Res Bull 80(4-5):268-73. [PubMed: 19683563] [MGI Ref ID J:186827]
Xiang Z; Ho L; Valdellon J; Borchelt D; Kelley K; Spielman L; Aisen PS; Pasinetti GM. 2002. Cyclooxygenase (COX)-2 and cell cycle activity in a transgenic mouse model of Alzheimer's disease neuropathology. Neurobiol Aging 23(3):327-34. [PubMed: 11959394] [MGI Ref ID J:100961]
Yan P; Bero AW; Cirrito JR; Xiao Q; Hu X; Wang Y; Gonzales E; Holtzman DM; Lee JM. 2009. Characterizing the appearance and growth of amyloid plaques in APP/PS1 mice. J Neurosci 29(34):10706-14. [PubMed: 19710322] [MGI Ref ID J:152312]
Zhang XM; Cai Y; Xiong K; Cai H; Luo XG; Feng JC; Clough RW; Struble RG; Patrylo PR; Yan XX. 2009. Beta-secretase-1 elevation in transgenic mouse models of Alzheimer's disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development. Eur J Neurosci 30(12):2271-83. [PubMed: 20092570] [MGI Ref ID J:157228]
Zhou XW; Gustafsson JA; Tanila H; Bjorkdahl C; Liu R; Winblad B; Pei JJ. 2008. Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A. Neurobiol Dis 31(3):386-94. [PubMed: 18586097] [MGI Ref ID J:138611]
van Groen T; Liu L; Ikonen S; Kadish I. 2003. Diffuse amyloid deposition, but not plaque number, is reduced in amyloid precursor protein/presenilin 1 double-transgenic mice by pathway lesions. Neuroscience 119(4):1185-97. [PubMed: 12831872] [MGI Ref ID J:100957]
Borchelt DR; Davis J; Fischer M; Lee MK; Slunt HH; Ratovitsky T; Regard J; Copeland NG; Jenkins NA; Sisodia SS; Price DL. 1996. A vector for expressing foreign genes in the brains and hearts of transgenic mice. Genet Anal 13(6):159-63. [PubMed: 9117892] [MGI Ref ID J:80782]
Cai Y; Xue ZQ; Zhang XM; Li MB; Wang H; Luo XG; Cai H; Yan XX. 2012. An age-related axon terminal pathology around the first olfactory relay that involves amyloidogenic protein overexpression without plaque formation. Neuroscience 215:160-73. [PubMed: 22542680] [MGI Ref ID J:192436]
Choi SH; Veeraraghavalu K; Lazarov O; Marler S; Ransohoff RM; Ramirez JM; Sisodia SS. 2008. Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation. Neuron 59(4):568-80. [PubMed: 18760694] [MGI Ref ID J:149876]
Cirrito JR; Disabato BM; Restivo JL; Verges DK; Goebel WD; Sathyan A; Hayreh D; D'Angelo G; Benzinger T; Yoon H; Kim J; Morris JC; Mintun MA; Sheline YI. 2011. Serotonin signaling is associated with lower amyloid-{beta} levels and plaques in transgenic mice and humans. Proc Natl Acad Sci U S A 108(36):14968-73. [PubMed: 21873225] [MGI Ref ID J:175216]
Dodson SE; Andersen OM; Karmali V; Fritz JJ; Cheng D; Peng J; Levey AI; Willnow TE; Lah JJ. 2008. Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's disease. J Neurosci 28(48):12877-86. [PubMed: 19036982] [MGI Ref ID J:142501]
El-Amouri SS; Zhu H; Yu J; Marr R; Verma IM; Kindy MS. 2008. Neprilysin: an enzyme candidate to slow the progression of Alzheimer's disease. Am J Pathol 172(5):1342-54. [PubMed: 18403590] [MGI Ref ID J:134308]
Garcia-Alloza M; Dodwell SA; Meyer-Luehmann M; Hyman BT; Bacskai BJ. 2006. Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model. J Neuropathol Exp Neurol 65(11):1082-9. [PubMed: 17086105] [MGI Ref ID J:120918]
Hou Y; Aboukhatwa MA; Lei DL; Manaye K; Khan I; Luo Y. 2010. Anti-depressant natural flavonols modulate BDNF and beta amyloid in neurons and hippocampus of double TgAD mice. Neuropharmacology 58(6):911-20. [PubMed: 19917299] [MGI Ref ID J:179562]
Jankowsky JL; Fadale DJ; Anderson J; Xu GM; Gonzales V; Jenkins NA; Copeland NG; Lee MK; Younkin LH; Wagner SL; Younkin SG; Borchelt DR. 2004. Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Hum Mol Genet 13(2):159-70. [PubMed: 14645205] [MGI Ref ID J:87691]
Jankowsky JL; Slunt HH; Ratovitski T; Jenkins NA; Copeland NG; Borchelt DR. 2001. Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. Biomol Eng 17(6):157-65. [PubMed: 11337275] [MGI Ref ID J:78664]
Jankowsky JL; Younkin LH; Gonzales V; Fadale DJ; Slunt HH; Lester HA; Younkin SG; Borchelt DR. 2007. Rodent A beta modulates the solubility and distribution of amyloid deposits in transgenic mice. J Biol Chem 282(31):22707-20. [PubMed: 17556372] [MGI Ref ID J:124804]
Kuchibhotla KV; Goldman ST; Lattarulo CR; Wu HY; Hyman BT; Bacskai BJ. 2008. Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks. Neuron 59(2):214-25. [PubMed: 18667150] [MGI Ref ID J:145474]
Lagadec S; Rotureau L; Hemar A; Macrez N; Delcasso S; Jeantet Y; Cho YH. 2012. Early temporal short-term memory deficits in double transgenic APP/PS1 mice. Neurobiol Aging 33(1):203.e1-11. [PubMed: 20817351] [MGI Ref ID J:188228]
Laird FM; Cai H; Savonenko AV; Farah MH; He K; Melnikova T; Wen H; Chiang HC; Xu G; Koliatsos VE; Borchelt DR; Price DL; Lee HK; Wong PC. 2005. BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. J Neurosci 25(50):11693-709. [PubMed: 16354928] [MGI Ref ID J:123534]
Lazarov O; Morfini GA; Pigino G; Gadadhar A; Chen X; Robinson J; Ho H; Brady ST; Sisodia SS. 2007. Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1. J Neurosci 27(26):7011-20. [PubMed: 17596450] [MGI Ref ID J:122975]
Lee GD; Aruna JH; Barrett PM; Lei DL; Ingram DK; Mouton PR. 2005. Stereological analysis of microvascular parameters in a double transgenic model of Alzheimer's disease. Brain Res Bull 65(4):317-22. [PubMed: 15811597] [MGI Ref ID J:135436]
Lee MK; Borchelt DR; Kim G; Thinakaran G; Slunt HH; Ratovitski T; Martin LJ; Kittur A; Gandy S; Levey AI; Jenkins N; Copeland N; Price DL; Sisodian SS. 1997. Hyperaccumulation of FAD-linked presenilin 1 variants in vivo Nat Med 3(7):756-60. [PubMed: 9212102] [MGI Ref ID J:104147]
Lesuisse C; Xu G; Anderson J; Wong M; Jankowsky J; Holtz G; Gonzalez V; Wong PC; Price DL; Tang F; Wagner S; Borchelt DR. 2001. Hyper-expression of human apolipoprotein E4 in astroglia and neurons does not enhance amyloid deposition in transgenic mice. Hum Mol Genet 10(22):2525-37. [PubMed: 11709540] [MGI Ref ID J:72987]
Liu HL; Zhao G; Cai K; Zhao HH; Shi LD. 2011. Treadmill exercise prevents decline in spatial learning and memory in APP/PS1 transgenic mice through improvement of hippocampal long-term potentiation. Behav Brain Res 218(2):308-14. [PubMed: 21192984] [MGI Ref ID J:168752]
Liu S; Liu Y; Hao W; Wolf L; Kiliaan AJ; Penke B; Rube CE; Walter J; Heneka MT; Hartmann T; Menger MD; Fassbender K. 2012. TLR2 is a primary receptor for Alzheimer's amyloid beta peptide to trigger neuroinflammatory activation. J Immunol 188(3):1098-107. [PubMed: 22198949] [MGI Ref ID J:180762]
Liu Y; Yoo MJ; Savonenko A; Stirling W; Price DL; Borchelt DR; Mamounas L; Lyons WE; Blue ME; Lee MK. 2008. Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease. J Neurosci 28(51):13805-14. [PubMed: 19091971] [MGI Ref ID J:143521]
Melnikova T; Savonenko A; Wang Q; Liang X; Hand T; Wu L; Kaufmann WE; Vehmas A; Andreasson KI. 2006. Cycloxygenase-2 activity promotes cognitive deficits but not increased amyloid burden in a model of Alzheimer's disease in a sex-dimorphic pattern. Neuroscience 141(3):1149-62. [PubMed: 16753269] [MGI Ref ID J:111748]
Oh ES; Savonenko AV; King JF; Fangmark Tucker SM; Rudow GL; Xu G; Borchelt DR; Troncoso JC. 2009. Amyloid precursor protein increases cortical neuron size in transgenic mice. Neurobiol Aging 30(8):1238-44. [PubMed: 18304698] [MGI Ref ID J:152955]
Perez SE; Dar S; Ikonomovic MD; DeKosky ST; Mufson EJ. 2007. Cholinergic forebrain degeneration in the APPswe/PS1DeltaE9 transgenic mouse. Neurobiol Dis 28(1):3-15. [PubMed: 17662610] [MGI Ref ID J:134818]
Perez SE; Lumayag S; Kovacs B; Mufson EJ; Xu S. 2008. {beta}-Amyloid Deposition and Functional Impairment in the Retina of the APPswe/PS1{Delta}E9 Transgenic Mouse Model of Alzheimer's Disease. Invest Ophthalmol Vis Sci 50(2):793-800. [PubMed: 18791173] [MGI Ref ID J:139070]
Pistell PJ; Zhu M; Ingram DK. 2008. Acquisition of conditioned taste aversion is impaired in the amyloid precursor protein/presenilin 1 mouse model of Alzheimer's disease. Neuroscience 152(3):594-600. [PubMed: 18304749] [MGI Ref ID J:135640]
Rodriguez JJ; Olabarria M; Chvatal A; Verkhratsky A. 2009. Astroglia in dementia and Alzheimer's disease. Cell Death Differ 16(3):378-85. [PubMed: 19057621] [MGI Ref ID J:158080]
Soderman A; Mikkelsen JD; West MJ; Christensen DZ; Jensen MS. 2011. Activation of nicotinic alpha(7) acetylcholine receptor enhances long term potentation in wild type mice but not in APP(swe)/PS1DeltaE9 mice. Neurosci Lett 487(3):325-9. [PubMed: 20974225] [MGI Ref ID J:168638]
Soderman A; Thomsen MS; Hansen HH; Nielsen EO; Jensen MS; West MJ; Mikkelsen JD. 2008. The nicotinic alpha7 acetylcholine receptor agonist ssr180711 is unable to activate limbic neurons in mice overexpressing human amyloid-beta1-42. Brain Res 1227:240-7. [PubMed: 18619425] [MGI Ref ID J:139987]
Szapacs ME; Numis AL; Andrews AM. 2004. Late onset loss of hippocampal 5-HT and NE is accompanied by increases in BDNF protein expression in mice co-expressing mutant APP and PS1. Neurobiol Dis 16(3):572-80. [PubMed: 15262269] [MGI Ref ID J:131666]
Tamboli IY; Prager K; Thal DR; Thelen KM; Dewachter I; Pietrzik CU; St George-Hyslop P; Sisodia SS; De Strooper B; Heneka MT; Filippov MA; Muller U; van Leuven F; Lutjohann D; Walter J. 2008. Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis. J Neurosci 28(46):12097-106. [PubMed: 19005074] [MGI Ref ID J:142399]
Tang J; Song M; Wang Y; Fan X; Xu H; Bai Y. 2009. Noggin and BMP4 co-modulate adult hippocampal neurogenesis in the APP(swe)/PS1(DeltaE9) transgenic mouse model of Alzheimer's disease. Biochem Biophys Res Commun 385(3):341-5. [PubMed: 19463786] [MGI Ref ID J:150675]
Thinakaran G; Borchelt DR; Lee MK; Slunt HH; Spitzer L; Kim G; Ratovitsky T; Davenport F; Nordstedt C; Seeger M; Hardy J; Levey AI; Gandy SE; Jenkins NA; Copeland NG; Price DL; Sisodia SS. 1996. Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron 17(1):181-90. [PubMed: 8755489] [MGI Ref ID J:34323]
Turdi S; Guo R; Huff AF; Wolf EM; Culver B; Ren J. 2009. Cardiomyocyte contractile dysfunction in the APPswe/PS1dE9 mouse model of Alzheimer's disease. PLoS One 4(6):e6033. [PubMed: 19551139] [MGI Ref ID J:150191]
Veeraraghavalu K; Choi SH; Zhang X; Sisodia SS. 2010. Presenilin 1 mutants impair the self-renewal and differentiation of adult murine subventricular zone-neuronal progenitors via cell-autonomous mechanisms involving notch signaling. J Neurosci 30(20):6903-15. [PubMed: 20484632] [MGI Ref ID J:160514]
Verret L; Jankowsky JL; Xu GM; Borchelt DR; Rampon C. 2007. Alzheimer's-type amyloidosis in transgenic mice impairs survival of newborn neurons derived from adult hippocampal neurogenesis. J Neurosci 27(25):6771-80. [PubMed: 17581964] [MGI Ref ID J:122001]
Wang X; Liu P; Zhu H; Xu Y; Ma C; Dai X; Huang L; Liu Y; Zhang L; Qin C. 2009. miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation. Brain Res Bull 80(4-5):268-73. [PubMed: 19683563] [MGI Ref ID J:186827]
Yan P; Bero AW; Cirrito JR; Xiao Q; Hu X; Wang Y; Gonzales E; Holtzman DM; Lee JM. 2009. Characterizing the appearance and growth of amyloid plaques in APP/PS1 mice. J Neurosci 29(34):10706-14. [PubMed: 19710322] [MGI Ref ID J:152312]
Zhang X; Garbett K; Veeraraghavalu K; Wilburn B; Gilmore R; Mirnics K; Sisodia SS. 2012. A Role for Presenilins in Autophagy Revisited: Normal Acidification of Lysosomes in Cells Lacking PSEN1 and PSEN2. J Neurosci 32(25):8633-48. [PubMed: 22723704] [MGI Ref ID J:185660]
Zhang XM; Cai Y; Xiong K; Cai H; Luo XG; Feng JC; Clough RW; Struble RG; Patrylo PR; Yan XX. 2009. Beta-secretase-1 elevation in transgenic mouse models of Alzheimer's disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development. Eur J Neurosci 30(12):2271-83. [PubMed: 20092570] [MGI Ref ID J:157228]
Health & husbandry
Health & Colony Maintenance Information
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, The Jackson Laboratory will maintain this line by mating (APP695/0, +/+) females with (+/+, PSEN1/0) males (or reciprocal). The transgenes are not linked (only 1 in 4 pups is a double transgenic); and the integration site is unknown. The Jackson Laboratory will distribute mice with the following genotypes: (PARENT 1) hemizygous APP695, wildtype PSEN1; (PARENT 2) wildtype APP695, hemizygous PSEN1; and (OFFSPRING) double hemizygotes. Control mice can be generated from this breeding pair or investigators can consider C57BL/6J (Stock 000664). While the donating investigator warns that transgenic females can exhibit suboptimal mothering of litters, no such complications have been observed in our colonies to date at The Jackson Laboratory (Jun 2006). Homozygosity may result in sterile males and reduced viability of females, and should be avoided for breeding stocks.
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This strain is currently Transferred.
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