Strain Name:

B6.Cg-Il10tm1Cgn (D3Mit49-D3Mit348)/Lt

Stock Number:

005912

Availability:

Repository-Cryopreserved

Use Restrictions Apply, see Terms of Use

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered Mutant Mice.
Specieslaboratory mouse
Background Strain B6.129P2-Il10tm1Cgn/JLt
Donor Strain C3H/HeJBir
GenerationN10F3pN1

Appearance
black
Related Genotype: a/a

Description
Homozygous mice are IL10-deficient and develop spontaneous colitic lesions in the cecum and large intestine as early as 6-8 weeks of age. The severity and age of onset of colitis varies with the donor type and location of the cytokine deficiency colitis susceptibility 1 (Cdcs1) interval. Generally, the C3H/HeJBir region encompassed by D3Mit348 through D3Mit254 (127.7-132.5 megabases) confers increased colitis susceptibility on the B6.129P2-Il10tm1Cgn background (Beckwith J, et al., 2005). Mice on the B6.129P2-Il10tm1Cgn background are prone to rectal prolapse particularly when carrying susceptibility alleles from Chromosome 3. Granulocyte populations in peripheral blood increase upon lesion development and provide a robust non-lethal assessment of colitis severity.

Development
A panel of reciprocal congenic stocks was generated by a marker assisted "speed congenic" approach. C3Bir.129P2(B6)-Il10tm1Cgn/Lt (Stock No. 004326) mice were backcrossed to B6.129P2-Il10tm1Cgn/JLt for 10 (N10) generations. Progeny were selected for a C3H/HeJBir donor interval within Cdcs1. This strain (Stock No. 005912) is called "BC-R2" in the primary reference (Beckwith 2005 Gastroenterology 129:1473), and contains the C3H/HeJBir donor interval defined by D3Mit49-D3Mit348. Of note, the BC-R2 mice described in Beckwith 2005 were backcrossed to B6.129P2-Il10tm1Cgn/JLt between 4-6 generations (N4-N6) generations.

Control Information

  Control
   002251 B6.129P2-Il10tm1Cgn/J (approximate)
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying   Il10tm1Cgn     (10 strains)

Additional Web Information

Congenic Nomenclature

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Cdcs1C3H/HeJBir/Cdcs1C3H/HeJBir

        involves: B6.129P2-Il10tm1Cgn/Lt * C3Bir.129P2(B6)-Il10tm1Cgn/Lt
  • digestive/alimentary phenotype
  • abnormal digestive system morphology (MGI Ref ID J:72978)
    • colitis
  • immune system phenotype
  • abnormal immune system physiology (MGI Ref ID J:72978)
    • susceptibility to colitis

Cdcs1C3H/HeJBir/Cdcs1C57BL/6J

        involves: C3H/HeJBir-Il10tm1Cgn * C57BL/6J-Il10tm1Cgn
  • digestive/alimentary phenotype
  • intestinal inflammation (MGI Ref ID J:72978)
    • colitis
  • immune system phenotype
  • intestinal inflammation (MGI Ref ID J:72978)
    • colitis
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Internal/Organ Research
Gastrointestinal Defects (colitis)

Il10tm1Cgn related

Cancer Research
Growth Factors/Receptors/Cytokines

Hematological Research
Anemia, Iron Deficiency and Transport Defects (hemolytic)
Immunological Defects

Immunology and Inflammation Research
Autoimmunity
Growth Factors/Receptors/Cytokines
Immunodeficiency
Inflammation (Inflammatory bowel disease)

Genes & Alleles

Gene & Allele Information

Allele Symbol Il10tm1Cgn
Allele Name targeted mutation 1, University of Cologne
Allele Type Targeted (knock-out)
Common Name(s) IL-10 KO; IL-10-; IL-10KO; IL-10KO; Il10-; Il10tmCgn;
Mutation Made By Ralf Kuhn,   University of Cologne
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14.1
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name Il10, interleukin 10
Chromosome 1
Gene Common Name(s) CSIF; IL-10; IL10A; IL10X; Il-10; MGC126450; MGC126451; TGIF; cytokine synthesis inhibitory factor;
Molecular Note A 500 bp genomic fragment containing codons 5-55 was replaced with a linker containing a termination codon followed by a neomycin cassette. A termination codon was also introduced into exon 3. No IL10 activity was detectable in ELISA assays in supernatants of in vitro splenic T cells derived from homozygous mice.
Gene Symbol and Name D3Mit348, DNA Segment, Chr 3 Massachusetts Institute of Technology 348
Chromosome 3
Gene Symbol and Name D3Mit49, DNA segment, Chr 3, Massachusetts Institute of Technology 49
Chromosome 3
Allele Symbol Cdcs1C3H/HeJBir
Allele Name C3H/HeJBir
Allele Type QTL
Strain of OriginC3Bir.129P2(B6)-Il10tm1Cgn/Lt
Gene Symbol and Name Cdcs1, cytokine deficiency colitis susceptibility 1
Chromosome 3

Genotyping

Genotyping Information

Genotyping Protocols

Il10tm1Cgn, STD PCR, vers. 1

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Beckwith J; Cong Y; Sundberg JP; Elson CO; Leiter EH. 2005. Cdcs1, a major colitogenic locus in mice, regulates innate and adaptive immune response to enteric bacterial antigens. Gastroenterology 129(5):1473-84. [PubMed: 16285949]  [MGI Ref ID J:101721]

Farmer MA; Sundberg JP; Bristol IJ; Churchill GA; Li R; Elson CO; Leiter EH. 2001. A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice. Proc Natl Acad Sci U S A 98(24):13820-5. [PubMed: 11707574]  [MGI Ref ID J:72978]

Additional References

Bleich A; Mahler M; Most C; Leiter EH; Liebler-Tenorio E; Elson CO; Hedrich HJ; Schlegelberger B; Sundberg JP. 2004. Refined histopathologic scoring system improves power to detect colitis QTL in mice. Mamm Genome 15(11):865-71. [PubMed: 15672590]  [MGI Ref ID J:94027]

Cdcs1C3H/HeJBir related

Bleich A; Mahler M; Most C; Leiter EH; Liebler-Tenorio E; Elson CO; Hedrich HJ; Schlegelberger B; Sundberg JP. 2004. Refined histopathologic scoring system improves power to detect colitis QTL in mice. Mamm Genome 15(11):865-71. [PubMed: 15672590]  [MGI Ref ID J:94027]

Il10tm1Cgn related

Akhiani AA; Stensson A; Schon K; Lycke NY. 2005. IgA antibodies impair resistance against Helicobacter pylori infection: studies on immune evasion in IL-10-deficient mice. J Immunol 174(12):8144-53. [PubMed: 15944323]  [MGI Ref ID J:100891]

Aliberti J; Viola JP; Vieira-de-Abreu A; Bozza PT; Sher A; Scharfstein J. 2003. Cutting edge: Bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarization. J Immunol 170(11):5349-53. [PubMed: 12759407]  [MGI Ref ID J:83453]

Allen HL; Deepe GS Jr. 2005. Apoptosis modulates protective immunity to the pathogenic fungus Histoplasma capsulatum. J Clin Invest 115(10):2875-85. [PubMed: 16151533]  [MGI Ref ID J:101533]

Allen HL; Deepe GS Jr. 2006. B cells and CD4-CD8- T cells are key regulators of the severity of reactivation histoplasmosis. J Immunol 177(3):1763-71. [PubMed: 16849486]  [MGI Ref ID J:138028]

Almeida AR; Legrand N; Papiernik M; Freitas AA. 2002. Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J Immunol 169(9):4850-60. [PubMed: 12391195]  [MGI Ref ID J:125748]

Amante FH; Stanley AC; Randall LM; Zhou Y; Haque A; McSweeney K; Waters AP; Janse CJ; Good MF; Hill GR; Engwerda CR. 2007. A role for natural regulatory T cells in the pathogenesis of experimental cerebral malaria. Am J Pathol 171(2):548-59. [PubMed: 17600128]  [MGI Ref ID J:123927]

Ameredes BT; Sethi JM; Liu HL; Choi AM; Calhoun WJ. 2005. Enhanced nitric oxide production associated with airway hyporesponsiveness in the absence of IL-10. Am J Physiol Lung Cell Mol Physiol 288(5):L868-73. [PubMed: 15618456]  [MGI Ref ID J:115459]

Ameredes BT; Zamora R; Gibson KF; Billiar TR; Dixon-McCarthy B; Watkins S; Calhoun WJ. 2001. Increased nitric oxide production by airway cells of sensitized and challenged IL-10 knockout mice. J Leukoc Biol 70(5):730-6. [PubMed: 11698492]  [MGI Ref ID J:124461]

Ameredes BT; Zamora R; Sethi JM; Liu HL; Kohut LK; Gligonic AL; Choi AM; Calhoun WJ. 2005. Alterations in nitric oxide and cytokine production with airway inflammation in the absence of IL-10. J Immunol 175(2):1206-13. [PubMed: 16002724]  [MGI Ref ID J:100726]

Ananieva O; Darragh J; Johansen C; Carr JM; McIlrath J; Park JM; Wingate A; Monk CE; Toth R; Santos SG; Iversen L; Arthur JS. 2008. The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling. Nat Immunol 9(9):1028-36. [PubMed: 18690222]  [MGI Ref ID J:139576]

Anderson AC; Reddy J; Nazareno R; Sobel RA; Nicholson LB; Kuchroo VK. 2004. IL-10 plays an important role in the homeostatic regulation of the autoreactive repertoire in naive mice. J Immunol 173(2):828-34. [PubMed: 15240669]  [MGI Ref ID J:91913]

Anderson CF; Oukka M; Kuchroo VJ; Sacks D. 2007. CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis. J Exp Med 204(2):285-97. [PubMed: 17283207]  [MGI Ref ID J:125372]

Andrassy M; Igwe J; Autschbach F; Volz C; Remppis A; Neurath MF; Schleicher E; Humpert PM; Wendt T; Liliensiek B; Morcos M; Schiekofer S; Thiele K; Chen J; Kientsch-Engel R; Schmidt AM; Stremmel W; Stern DM; Katus HA; Nawroth PP; Bierhaus A. 2006. Posttranslationally modified proteins as mediators of sustained intestinal inflammation. Am J Pathol 169(4):1223-37. [PubMed: 17003481]  [MGI Ref ID J:113376]

Apte RS; Richter J; Herndon J; Ferguson TA. 2006. Macrophages inhibit neovascularization in a murine model of age-related macular degeneration. PLoS Med 3(8):e310. [PubMed: 16903779]  [MGI Ref ID J:134144]

Arsenescu R; Blum AM; Metwali A; Elliott DE; Weinstock JV. 2005. IL-12 induction of mRNA encoding substance P in murine macrophages from the spleen and sites of inflammation. J Immunol 174(7):3906-11. [PubMed: 15778345]  [MGI Ref ID J:110005]

Auerbuch V; Isberg RR. 2007. Growth of Yersinia pseudotuberculosis in Mice Occurs Independently of Toll-Like Receptor 2 Expression and Induction of Interleukin-10. Infect Immun 75(7):3561-70. [PubMed: 17420232]  [MGI Ref ID J:122417]

Awasthi A; Carrier Y; Peron JP; Bettelli E; Kamanaka M; Flavell RA; Kuchroo VK; Oukka M; Weiner HL. 2007. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat Immunol 8(12):1380-9. [PubMed: 17994022]  [MGI Ref ID J:127774]

Balasa B; La Cava A; Van Gunst K; Mocnik L; Balakrishna D; Nguyen N; Tucker L; Sarvetnick N. 2000. A mechanism for IL-10-mediated diabetes in the nonobese diabetic (NOD) mouse: ICAM-1 deficiency blocks accelerated diabetes J Immunol 165(12):7330-7. [PubMed: 11120869]  [MGI Ref ID J:66103]

Balasa B; Van Gunst K; Jung N; Katz JD; Sarvetnick N. 2000. IL-10 deficiency does not inhibit insulitis and accelerates cyclophosphamide-induced diabetes in the nonobese diabetic mouse. Cell Immunol 202(2):97-102. [PubMed: 10896769]  [MGI Ref ID J:114170]

Bandukwala HS; Clay BS; Tong J; Mody PD; Cannon JL; Shilling RA; Verbeek JS; Weinstock JV; Solway J; Sperling AI. 2007. Signaling through Fc gamma RIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation. J Exp Med 204(8):1875-89. [PubMed: 17664287]  [MGI Ref ID J:125951]

Beenhouwer DO; Shapiro S; Feldmesser M; Casadevall A; Scharff MD. 2001. Both Th1 and Th2 Cytokines Affect the Ability of Monoclonal Antibodies To Protect Mice against Cryptococcus neoformans. Infect Immun 69(10):6445-55. [PubMed: 11553589]  [MGI Ref ID J:71570]

Beissert S; Hosoi J; Kuhn R; Rajewsky K; Muller W; Granstein RD. 1996. Impaired immunosuppressive response to ultraviolet radiation in interleukin-10-deficient mice. J Invest Dermatol 107(4):553-7. [PubMed: 8823360]  [MGI Ref ID J:35510]

Beiting DP; Bliss SK; Schlafer DH; Roberts VL; Appleton JA. 2004. Interleukin-10 limits local and body cavity inflammation during infection with muscle-stage Trichinella spiralis. Infect Immun 72(6):3129-37. [PubMed: 15155614]  [MGI Ref ID J:90250]

Belkaid Y; Hoffmann KF; Mendez S; Kamhawi S; Udey MC; Wynn TA; Sacks DL. 2001. The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure. J Exp Med 194(10):1497-506. [PubMed: 11714756]  [MGI Ref ID J:118003]

Berg DJ; Davidson N; Kuhn R; Muller W; Menon S; Holland G; Thompson-Snipes L; Leach MW; Rennick D. 1996. Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J Clin Invest 98(4):1010-20. [PubMed: 8770874]  [MGI Ref ID J:35020]

Berg DJ; Leach MW; Kuhn R; Rajewsky K; Muller W; Davidson NJ; Rennick D. 1995. Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses. J Exp Med 182(1):99-108. [PubMed: 7790826]  [MGI Ref ID J:26221]

Bernert H; Sekikawa K; Radcliffe RA; Iraqi F; You M; Malkinson AM. 2003. Tnfa and Il-10 deficiencies have contrasting effects on lung tumor susceptibility: Gender-dependent modulation of IL-10 haploinsufficiency. Mol Carcinog 38(3):117-23. [PubMed: 14587096]  [MGI Ref ID J:86489]

Bettelli E; Das MP; Howard ED; Weiner HL; Sobel RA; Kuchroo VK. 1998. IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice. J Immunol 161(7):3299-306. [PubMed: 9759845]  [MGI Ref ID J:115204]

Biburger M; Tiegs G. 2008. Activation-induced NKT cell hyporesponsiveness protects from alpha-galactosylceramide hepatitis and is independent of active transregulatory factors. J Leukoc Biol 84(1):264-79. [PubMed: 18407967]  [MGI Ref ID J:137749]

Bliss SK; Alcaraz A; Appleton JA. 2003. IL-10 prevents liver necrosis during murine infection with Trichinella spiralis. J Immunol 171(6):3142-7. [PubMed: 12960341]  [MGI Ref ID J:85372]

Blois SM; Ilarregui JM; Tometten M; Garcia M; Orsal AS; Cordo-Russo R; Toscano MA; Bianco GA; Kobelt P; Handjiski B; Tirado I; Markert UR; Klapp BF; Poirier F; Szekeres-Bartho J; Rabinovich GA; Arck PC. 2007. A pivotal role for galectin-1 in fetomaternal tolerance. Nat Med 13(12):1450-7. [PubMed: 18026113]  [MGI Ref ID J:130208]

Blum A; Setiawan T; Hang L; Stoyanoff K; Weinstock JV. 2008. Interleukin-12 (IL-12) and IL-23 induction of substance p synthesis in murine T cells and macrophages is subject to IL-10 and transforming growth factor beta regulation. Infect Immun 76(8):3651-6. [PubMed: 18505813]  [MGI Ref ID J:139373]

Bosschaerts T; Guilliams M; Noel W; Herin M; Burk RF; Hill KE; Brys L; Raes G; Ghassabeh GH; De Baetselier P; Beschin A. 2008. Alternatively activated myeloid cells limit pathogenicity associated with African trypanosomiasis through the IL-10 inducible gene selenoprotein P. J Immunol 180(9):6168-75. [PubMed: 18424738]  [MGI Ref ID J:134536]

Bristol IJ; Farmer MA; Cong Y; Zheng XX; Strom TB; Elson CO; Sundberg JP; Leiter EH. 2000. Heritable susceptibility for colitis in mice induced by IL-10 deficiency. Inflamm Bowel Dis 6(4):290-302. [PubMed: 11149562]  [MGI Ref ID J:109882]

Brooks DG; Trifilo MJ; Edelmann KH; Teyton L; McGavern DB; Oldstone MB. 2006. Interleukin-10 determines viral clearance or persistence in vivo. Nat Med 12(11):1301-9. [PubMed: 17041596]  [MGI Ref ID J:115332]

Bundoc VG; Keane-Myers A. 2007. IL-10 confers protection from mast cell degranulation in a mouse model of allergic conjunctivitis. Exp Eye Res 85(4):575-9. [PubMed: 17765892]  [MGI Ref ID J:126367]

Burich A; Hershberg R; Waggie K; Zeng W; Brabb T; Westrich G; Viney JL; Maggio-Price L. 2001. Helicobacter-induced inflammatory bowel disease in IL-10- and T cell-deficient mice. Am J Physiol Gastrointest Liver Physiol 281(3):G764-78. [PubMed: 11518689]  [MGI Ref ID J:108283]

Buxbaum LU; Scott P. 2005. Interleukin 10- and Fcgamma receptor-deficient mice resolve Leishmania mexicana lesions. Infect Immun 73(4):2101-8. [PubMed: 15784551]  [MGI Ref ID J:97206]

Cain JA; Smith JA; Ondr JK; Wang B; Katz JD. 2006. NKT cells and IFN-gamma establish the regulatory environment for the control of diabetogenic T cells in the nonobese diabetic mouse. J Immunol 176(3):1645-54. [PubMed: 16424194]  [MGI Ref ID J:126603]

Caligiuri G; Rudling M; Ollivier V; Jacob MP; Michel JB; Hansson GK; Nicoletti A. 2003. Interleukin-10 deficiency increases atherosclerosis, thrombosis, and low-density lipoproteins in apolipoprotein E knockout mice. Mol Med 9(1-2):10-7. [PubMed: 12765335]  [MGI Ref ID J:105858]

Cantorna MT; Munsick C; Bemiss C; Mahon BD. 2000. 1,25-Dihydroxycholecalciferol prevents and ameliorates symptoms of experimental murine inflammatory bowel disease J Nutr 130(11):2648-52. [PubMed: 11053501]  [MGI Ref ID J:65513]

Carregaro V; Valenzuela JG; Cunha TM; Verri WA Jr; Grespan R; Matsumura G; Ribeiro JM; Elnaiem DE; Silva JS; Cunha FQ. 2008. Phlebotomine salivas inhibit immune inflammation-induced neutrophil migration via an autocrine DC-derived PGE2/IL-10 sequential pathway. J Leukoc Biol 84(1):104-14. [PubMed: 18390928]  [MGI Ref ID J:137750]

Carrero JA; Calderon B; Unanue ER. 2006. Lymphocytes are detrimental during the early innate immune response against Listeria monocytogenes. J Exp Med 203(4):933-40. [PubMed: 16549598]  [MGI Ref ID J:123753]

Carroll IM; Andrus JM; Bruno-Barcena JM; Klaenhammer TR; Hassan HM; Threadgill DS. 2007. Anti-inflammatory properties of Lactobacillus gasseri expressing manganese superoxide dismutase using the interleukin 10-deficient mouse model of colitis. Am J Physiol Gastrointest Liver Physiol 293(4):G729-38. [PubMed: 17640978]  [MGI Ref ID J:126666]

Chelvarajan L; Popa D; Liu Y; Getchell TV; Stromberg AJ; Bondada S. 2007. Molecular mechanisms underlying anti-inflammatory phenotype of neonatal splenic macrophages. J Leukoc Biol 82(2):403-16. [PubMed: 17495050]  [MGI Ref ID J:123516]

Chen W; Shu D; Chadwick VS. 2001. Helicobacter pylori infection: mechanism of colonization and functional dyspepsia Reduced colonization of gastric mucosa by Helicobacter pylori in mice deficient in interleukin-10. J Gastroenterol Hepatol 16(4):377-83. [PubMed: 11354274]  [MGI Ref ID J:103513]

Chiaramonte MG; Hesse M; Cheever AW; Wynn TA. 2000. CpG oligonucleotides can prophylactically immunize against Th2-mediated schistosome egg-induced pathology by an IL-12-independent mechanism. J Immunol 164(2):973-85. [PubMed: 10623847]  [MGI Ref ID J:127058]

Chiaramonte MG; Mentink-Kane M; Jacobson BA; Cheever AW; Whitters MJ; Goad ME; Wong A; Collins M; Donaldson DD; Grusby MJ; Wynn TA. 2003. Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response. J Exp Med 197(6):687-701. [PubMed: 12642601]  [MGI Ref ID J:124413]

Chmiel JF; Konstan MW; Saadane A; Krenicky JE; Lester Kirchner H; Berger M. 2002. Prolonged inflammatory response to acute Pseudomonas challenge in interleukin-10 knockout mice. Am J Respir Crit Care Med 165(8):1176-81. [PubMed: 11956064]  [MGI Ref ID J:103028]

Clemons KV; Grunig G; Sobel RA; Mirels LF; Rennick DM; Stevens DA. 2000. Role of IL-10 in invasive aspergillosis: increased resistance of IL-10 gene knockout mice to lethal systemic aspergillosis Clin Exp Immunol 122(2):186-91. [PubMed: 11091273]  [MGI Ref ID J:65686]

Czarneski J; Lin YC; Chong S; McCarthy B; Fernandes H; Parker G; Mansour A; Huppi K; Marti GE; Raveche E. 2004. Studies in NZB IL-10 knockout mice of the requirement of IL-10 for progression of B-cell lymphoma. Leukemia 18(3):597-606. [PubMed: 14712288]  [MGI Ref ID J:88136]

D'Orazio TJ; Niederkorn JY. 1998. A novel role for TGF-beta and IL-10 in the induction of immune privilege. J Immunol 160(5):2089-98. [PubMed: 9498745]  [MGI Ref ID J:111362]

Dai WJ; Kohler G; Brombacher F. 1997. Both innate and acquired immunity to Listeria monocytogenes infection are increased in IL-10-deficient mice. J Immunol 158(5):2259-67. [PubMed: 9036973]  [MGI Ref ID J:110855]

Das G; Augustine MM; Das J; Bottomly K; Ray P; Ray A. 2003. An important regulatory role for CD4+CD8 alpha alpha T cells in the intestinal epithelial layer in the prevention of inflammatory bowel disease. Proc Natl Acad Sci U S A 100(9):5324-9. [PubMed: 12695566]  [MGI Ref ID J:83283]

Davidson NJ; Fort MM; Muller W; Leach MW; Rennick DM. 2000. Chronic colitis in IL-10-/- mice: insufficient counter regulation of a Th1 response Int Rev Immunol 19(1):91-121. [PubMed: 10723680]  [MGI Ref ID J:61253]

Davidson NJ; Leach MW; Fort MM; Thompson-Snipes L; Kuhn R; Muller W; Berg DJ; Rennick DM. 1996. T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice. J Exp Med 184(1):241-51. [PubMed: 8691138]  [MGI Ref ID J:34035]

De Fazio SR; Gozzo JJ. 2000. Role of graft interleukin-10 expression in the tolerogenicity of neonatal skin allografts Transplantation 70(9):1371-7. [PubMed: 11087155]  [MGI Ref ID J:65782]

Deepe GS Jr; Gibbons RS. 2003. Protective and memory immunity to Histoplasma capsulatum in the absence of IL-10. J Immunol 171(10):5353-62. [PubMed: 14607938]  [MGI Ref ID J:117988]

Del Sero G; Mencacci A; Cenci E; d'Ostiani CF; Montagnoli C; Bacci A; Mosci P; Kopf M; Romani L. 1999. Antifungal type 1 responses are upregulated in IL-10-deficient mice. Microbes Infect 1(14):1169-80. [PubMed: 10580272]  [MGI Ref ID J:106542]

Demangel C; Bertolino P; Britton WJ. 2002. Autocrine IL-10 impairs dendritic cell (DC)-derived immune responses to mycobacterial infection by suppressing DC trafficking to draining lymph nodes and local IL-12 production. Eur J Immunol 32(4):994-1002. [PubMed: 11920565]  [MGI Ref ID J:75998]

Demols A; Van Laethem JL; Quertinmont E; Degraef C; Delhaye M; Geerts A; Deviere J. 2002. Endogenous interleukin-10 modulates fibrosis and regeneration in experimental chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol 282(6):G1105-12. [PubMed: 12016137]  [MGI Ref ID J:108286]

Denning TL; Wang YC; Patel SR; Williams IR; Pulendran B. 2007. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat Immunol 8(10):1086-94. [PubMed: 17873879]  [MGI Ref ID J:125258]

Dercamp C; Chemin K; Caux C; Trinchieri G; Vicari AP. 2005. Distinct and overlapping roles of interleukin-10 and CD25+ regulatory T cells in the inhibition of antitumor CD8 T-cell responses. Cancer Res 65(18):8479-86. [PubMed: 16166328]  [MGI Ref ID J:101610]

Di Marco R; Xiang M; Zaccone P; Leonardi C; Franco S; Meroni P; Nicoletti F. 1999. Concanavalin A-induced hepatitis in mice is prevented by interleukin (IL)-10 and exacerbated by endogenous IL-10 deficiency Autoimmunity 31(2):75-83. [PubMed: 10680745]  [MGI Ref ID J:60463]

DiFedele LM; He J; Bonkowski EL; Han X; Held MA; Bohan A; Menon RK; Denson LA. 2005. Tumor necrosis factor alpha blockade restores growth hormone signaling in murine colitis. Gastroenterology 128(5):1278-91. [PubMed: 15887111]  [MGI Ref ID J:124938]

Dieleman LA; Arends A; Tonkonogy SL; Goerres MS; Craft DW; Grenther W; Sellon RK; Balish E; Sartor RB. 2000. Helicobacter hepaticus does not induce or potentiate colitis in interleukin-10-deficient mice. Infect Immun 68(9):5107-13. [PubMed: 10948132]  [MGI Ref ID J:64076]

Dresner-Pollak R; Gelb N; Rachmilewitz D; Karmeli F; Weinreb M. 2004. Interleukin 10-deficient mice develop osteopenia, decreased bone formation, and mechanical fragility of long bones. Gastroenterology 127(3):792-801. [PubMed: 15362035]  [MGI Ref ID J:93577]

Dubois B; Chapat L; Goubier A; Papiernik M; Nicolas JF; Kaiserlian D. 2003. Innate CD4+CD25+ regulatory T cells are required for oral tolerance and inhibition of CD8+ T cells mediating skin inflammation. Blood 102(9):3295-301. [PubMed: 12855551]  [MGI Ref ID J:115675]

Eaton KA; Mefford M; Thevenot T. 2001. The role of T cell subsets and cytokines in the pathogenesis of Helicobacter pylori gastritis in mice. J Immunol 166(12):7456-61. [PubMed: 11390498]  [MGI Ref ID J:124425]

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