Strain Name:

B6;D1Lac-Scd1ab-2J/J

Stock Number:

005956

Order this mouse

Availability:

Research Strain

Mice homozygous for the Scd1ab-2J allele show slightly hunched posture, dry, scaly skin, thin fur, and small eyes with encrusted eyelids stuck shut. They have hypoplasia of the sebaceous glands and other hair follicle abnormalities that result in scarring alopecia. They also have a paucity of adipose tissue, thin subcutis, and a distinctive odor.

Description

Strain Information

Type Mutant Stock; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse

Description
The overall appearance of mice homozygous for either the Scd1ab-J allele or the Scd1ab-2J allele (Stock No. 002304 or 005956) includes slightly hunched posture, dry, scaly skin, thin fur sometimes detectable by 7 days of age, and small eyes with encrusted eyelids stuck shut. They have hypoplasia of the sebaceous glands and other hair follicle abnormalities that result in scarring alopecia. These mice have a paucity of adipose tissue, thin subcutis, and a distinctive odor. Hepatic cholesterol ester and triglyceride synthesis has been shown to be deficient in Scd1ab-J homozygotes and could not be restored through diet. Early studies of skin lipids in the original asebia mutant (Scd1ab) revealed a deficiency in wax esters, wax diesters, and sterols esterified with very long-chain fatty acids along with an increase in free sterols. (Wilkinson and Darasek 1966; Sundberg et al. 1994; Zheng et al. 1999; Miyazaki et al. 2000; Sundberg et al. 2000)

Mice homozygous for the Scd1ab-2J allele have greater dermal inflammatory infiltrate in the skin and thicker epidermis than do Scd1ab-J mice. Scd1ab-2J homozygotes show an increased transepidermal water loss and corresponding ad libitum intake of water that is not seen in Scd1ab-J homozygotes. For a thorough description see Sundberg et al. 2000 and Sundberg 1994.

Control Information

  Control
   None Available
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Scd1ab-2J allele
002304   DBA/1LacJ-Scd1ab-2J/J
View Strains carrying   Scd1ab-2J     (1 strain)

Strains carrying other alleles of Scd1
006201   B6.129-Scd1tm1Ntam/J
022794   B6.Cg-Tg(ACTA1-Scd1)282Ptn/J
View Strains carrying other alleles of Scd1     (2 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Scd1ab-2J/Scd1ab-2J

        DBA/1LacJ-Scd1ab-2J/J
  • behavior/neurological phenotype
  • hunched posture   (MGI Ref ID J:62699)
  • increased fluid intake   (MGI Ref ID J:62699)
  • homeostasis/metabolism phenotype
  • abnormal lipid level
    • mice exhibit a reduction in skin surface lipids such as sterol esters and cholesterol with a total loss of diol esters unlike in wild-type mice   (MGI Ref ID J:62699)
  • impaired skin barrier function
    • transepidermal water loss is increased 4.5-fold compared to in wild-type mice   (MGI Ref ID J:62699)
  • immune system phenotype
  • granulomatous inflammation
    • hair shafts rupture through the base of the hair follicle and induce a foreign body granuloma in the dermal stroma resulting in dermal scarring and eventually scarring of the hair follicle   (MGI Ref ID J:62699)
  • renal/urinary system phenotype
  • polyuria
    • urine output is increased by 2% compared to in wild-type mice   (MGI Ref ID J:62699)
  • endocrine/exocrine gland phenotype
  • abnormal meibomian gland morphology
  • sebaceous gland atrophy
    • at day 6 mice have very small sebaceous glands compared to in wild-type mice   (MGI Ref ID J:62699)
    • mice have small meibomian, perianal and cerimous glands   (MGI Ref ID J:62699)
    • however, preputial, clitoral, lingual, Harderian and lacrimal glands are normal   (MGI Ref ID J:62699)
  • vision/eye phenotype
  • abnormal meibomian gland morphology
  • integument phenotype
  • abnormal hair cycle
    • follicles stay in anagen longer than in wild-type mice   (MGI Ref ID J:62699)
    • while few follicles continue to cycle, with each cycle there is a progressive loss of individual follicles   (MGI Ref ID J:62699)
  • abnormal hair follicle morphology
    • hair shafts rupture through the base of the hair follicle and induce a foreign body granuloma in the dermal stroma resulting in dermal scarring and eventually scarring of the hair follicle   (MGI Ref ID J:62699)
    • abnormal hair follicle bulb morphology
      • hair follicle bulbar histology is distorted compared to in wild-type mice   (MGI Ref ID J:62699)
    • abnormal hair follicle inner root sheath morphology
      • the inner root sheath is retained beyond the midfollicle into the outer piliary canal unlike in wild-type mice   (MGI Ref ID J:62699)
    • enlarged hair follicles
      • during the first anagen stage the hair follicles are unusually long and extend at a sharp angle into the deep subcutis unlike in wild-type mice   (MGI Ref ID J:62699)
  • abnormal hair shaft morphology
    • hair shafts rupture through the base of the hair follicle and induce a foreign body granuloma in the dermal stroma resulting in dermal scarring and eventually scarring of the hair follicle   (MGI Ref ID J:62699)
  • abnormal meibomian gland morphology
  • abnormal skin morphology
    • mice exhibit thicker than normal epidermis, Malphigian layer and stratum corneum   (MGI Ref ID J:62699)
    • acanthosis   (MGI Ref ID J:62699)
    • dry skin   (MGI Ref ID J:62699)
    • flaky skin
      • moderate white flaking is observed when hair is removed unlike in wild-type mice   (MGI Ref ID J:62699)
    • orthokeratosis
      • mice exhibit varying degrees of orthokeratotic hyperkeratosis   (MGI Ref ID J:62699)
    • parakeratosis
      • in focal areas   (MGI Ref ID J:62699)
    • scaly skin   (MGI Ref ID J:62699)
    • thick dermal layer   (MGI Ref ID J:62699)
    • thick epidermis   (MGI Ref ID J:62699)
  • impaired skin barrier function
    • transepidermal water loss is increased 4.5-fold compared to in wild-type mice   (MGI Ref ID J:62699)
  • matted coat   (MGI Ref ID J:62699)
  • sebaceous gland atrophy
    • at day 6 mice have very small sebaceous glands compared to in wild-type mice   (MGI Ref ID J:62699)
    • mice have small meibomian, perianal and cerimous glands   (MGI Ref ID J:62699)
    • however, preputial, clitoral, lingual, Harderian and lacrimal glands are normal   (MGI Ref ID J:62699)
  • sparse hair   (MGI Ref ID J:62699)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Scd1ab-2J related

Cardiovascular Research
Hypotriglyceridemia

Dermatology Research
Skin and Hair Texture Defects

Internal/Organ Research
Adipose Defects

Metabolism Research
Lipid Metabolism

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Scd1ab-2J
Allele Name asebia 2 Jackson
Allele Type Spontaneous
Strain of OriginDBA/1LacJ
Gene Symbol and Name Scd1, stearoyl-Coenzyme A desaturase 1
Chromosome 19
Gene Common Name(s) AA589638; AI265570; FADS5; MSTP008; SCD; SCDOS; Scd-1; ab; asebia; expressed sequence AA589638; expressed sequence AI265570; stearoyl-CoA desaturase;
Molecular Note An 18 bp deletion in the exon 2/intron 2 boundary. [MGI Ref ID J:58283]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Scd1ab-2J related

MacDonald ML; Singaraja RR; Bissada N; Ruddle P; Watts R; Karasinska JM; Gibson WT; Fievet C; Vance JE; Staels B; Hayden MR. 2008. Absence of stearoyl-CoA desaturase-1 ameliorates features of the metabolic syndrome in LDLR-deficient mice. J Lipid Res 49(1):217-29. [PubMed: 17960025]  [MGI Ref ID J:130278]

MacDonald ML; van Eck M; Hildebrand RB; Wong BW; Bissada N; Ruddle P; Kontush A; Hussein H; Pouladi MA; Chapman MJ; Fievet C; van Berkel TJ; Staels B; McManus BM; Hayden MR. 2009. Despite antiatherogenic metabolic characteristics, SCD1-deficient mice have increased inflammation and atherosclerosis. Arterioscler Thromb Vasc Biol 29(3):341-7. [PubMed: 19095997]  [MGI Ref ID J:160858]

Macdonald ML; Bissada N; Vallance BA; Hayden MR. 2009. Absence of stearoyl-CoA desaturase-1 does not promote DSS-induced acute colitis. Biochim Biophys Acta 1791(12):1166-72. [PubMed: 19695343]  [MGI Ref ID J:164853]

Nikonova L; Koza RA; Mendoza T; Chao PM; Curley JP; Kozak LP. 2008. Mesoderm-specific transcript is associated with fat mass expansion in response to a positive energy balance. FASEB J 22(11):3925-37. [PubMed: 18644838]  [MGI Ref ID J:157437]

Sundberg JP; Boggess D; Sundberg BA; Eilertsen K; Parimoo S; Filippi M; Stenn K. 2000. Asebia-2J (Scd1(ab2J)): a new allele and a model for scarring alopecia. Am J Pathol 156(6):2067-75. [PubMed: 10854228]  [MGI Ref ID J:62699]

Zheng Y; Eilertsen KJ; Ge L; Zhang L; Sundberg JP; Prouty SM; Stenn KS; Parimoo S. 1999. Scd1 is expressed in sebaceous glands and is disrupted in the asebia mouse [letter] Nat Genet 23(3):268-70. [PubMed: 10545940]  [MGI Ref ID J:58283]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           A1

Colony Maintenance

Breeding & HusbandryThe homozygotes are very poor breeders and the mutation is best maintained using heterozygous females bred to homozygous males.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $191.20Female or MaleHomozygous for Scd1ab-2J  
Price per Pair (US dollars $)Pair Genotype
$382.40Homozygous for Scd1ab-2J x Homozygous for Scd1ab-2J  

Standard Supply

Research Strain. Availability determined by The Jackson Laboratory scientist holding the strain.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $248.60Female or MaleHomozygous for Scd1ab-2J  
Price per Pair (US dollars $)Pair Genotype
$497.20Homozygous for Scd1ab-2J x Homozygous for Scd1ab-2J  

Standard Supply

Research Strain. Availability determined by The Jackson Laboratory scientist holding the strain.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Research Strain. Availability determined by The Jackson Laboratory scientist holding the strain.

General Supply Notes

Control Information

  Control
   None Available
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.5)