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The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain C3H/HeJBirLt
Donor Strain 129P2/OlaHsd via B6.129P2-Il10tm1Cgn/J
H2 Haplotypek
Generation Definitions

Related Genotype: A/A

Important Note
This strain is homozygous for Pde6brd1 and Tlr4Lps-d.

This is a control strain for C3Bir.129P2(B6)-Il10tm1Cgn/Lt (Stock No. 004326), developed in parallel with the latter until backcrossing was complete. As such, it does not exhibit the Il10-deficient phenotype.

This is a control strain for C3Bir.129P2(B6)-Il10tm1Cgn/Lt (Stock No. 004326), developed in parallel with the latter until backcrossing was complete.

The Il10tm1Cgn mutation was created by in the Laboratory of Dr. Werner Muller at the University of Cologne. Briefly, a targeting vector was designed to replace codons 5-55 of exon 1 of the targeted gene with a 24 bp linker (providing a termination codon) and a neo expression cassette, as well as introduce a termination codon into exon 3. The construct was electroporated into 129P2/OlaHsd-derived E14-1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient C57BL/6 blastocysts and chimeric males were bred with C57BL/6 females to establish the mutant colony on a mixed B6;129P2 genetic background. It was then imported to the Induced Mutant Resource at The Jackson Laboratory in 1995. Subsequently, mutant mice were backcrossed to the C3H/HeJBirLt host strain for at least 10 generations. At the tenth backcross generation, heterozygotes were intercrossed to produce founders for a homozygous mutant line (Stock No. 004326) as well as founders for this wildtype control line (Stock No. 005973). This strain was imported into The Jackson Laboratory Repository at N15F15 from the research laboratory of Dr. Ed Leiter in 2006.

Control Information

   See control note: This strain is a control for 004326 and 003968.
  Considerations for Choosing Controls

Related Strains

Strains carrying   Tlr4Lps-d allele
002930   C.C3-Tlr4Lps-d/J
004326   C3Bir.129P2(B6)-Il10tm1Cgn/Lt
003968   C3Bir.129P2(B6)-Il10tm1Cgn/LtJ
000659   C3H/HeJ
005972   C3H/HeJBirLtJ
View Strains carrying   Tlr4Lps-d     (5 strains)

View Strains carrying other alleles of Il10     (13 strains)

Strains carrying other alleles of Tlr4
024872   B6(Cg)-Tlr4tm1.1Karp/J
007227   B6.B10ScN-Tlr4lps-del/JthJ
000029   BXD29-Tlr4lps-2J/J
003752   C57BL/10ScNJ
View Strains carrying other alleles of Tlr4     (4 strains)


Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research
      control strain

Tlr4Lps-d related

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
      Tlr deficiency
      Tlr deficiency
      Tlr deficiency

Genes & Alleles

Gene & Allele Information provided by MGI

Gene Symbol and Name Il10, interleukin 10
Chromosome 1
Gene Common Name(s) CSIF; GVHDS; IL-10; IL10A; IL10X; Il-10; TGIF; cytokine synthesis inhibitory factor;
Allele Symbol Tlr4Lps-d
Allele Name defective lipopolysaccharide response
Allele Type Spontaneous
Common Name(s) TLR4-M; TLR4-Mu; TLR4lps-def; TLR4d; Tlr4-; Tlr4d; TlrLps-d; lpsd; mutant TLR4;
Strain of OriginC3H/HeJ
Gene Symbol and Name Tlr4, toll-like receptor 4
Chromosome 4
Gene Common Name(s) ARMD10; CD284; Lps; RAS-like, family 2, locus 8; Rasl2-8; TLR-4; TOLL; lipopolysaccharide response;


Genotyping Information

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Additional References

Tlr4Lps-d related

Abel B; Thieblemont N; Quesniaux VJ; Brown N; Mpagi J; Miyake K; Bihl F; Ryffel B. 2002. Toll-like receptor 4 expression is required to control chronic Mycobacterium tuberculosis infection in mice. J Immunol 169(6):3155-62. [PubMed: 12218133]  [MGI Ref ID J:78959]

An CH; Wang XM; Lam HC; Ifedigbo E; Washko GR; Ryter SW; Choi AM. 2012. TLR4 deficiency promotes autophagy during cigarette smoke-induced pulmonary emphysema. Am J Physiol Lung Cell Mol Physiol 303(9):L748-57. [PubMed: 22983353]  [MGI Ref ID J:193661]

Andonegui G; Bonder CS; Green F; Mullaly SC; Zbytnuik L; Raharjo E; Kubes P. 2003. Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs. J Clin Invest 111(7):1011-20. [PubMed: 12671050]  [MGI Ref ID J:82623]

Andonegui G; Goyert SM; Kubes P. 2002. Lipopolysaccharide-induced leukocyte-endothelial cell interactions: a role for CD14 versus toll-like receptor 4 within microvessels. J Immunol 169(4):2111-9. [PubMed: 12165539]  [MGI Ref ID J:120701]

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Arizmendi NG; Abel M; Mihara K; Davidson C; Polley D; Nadeem A; El Mays T; Gilmore BF; Walker B; Gordon JR; Hollenberg MD; Vliagoftis H. 2011. Mucosal allergic sensitization to cockroach allergens is dependent on proteinase activity and proteinase-activated receptor-2 activation. J Immunol 186(5):3164-72. [PubMed: 21270400]  [MGI Ref ID J:169393]

Askenase PW; Itakura A; Leite-de-Moraes MC; Lisbonne M; Roongapinun S; Goldstein DR; Szczepanik M. 2005. TLR-dependent IL-4 production by invariant Valpha14+Jalpha18+ NKT cells to initiate contact sensitivity in vivo. J Immunol 175(10):6390-401. [PubMed: 16272291]  [MGI Ref ID J:119381]

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Babcock AA; Wirenfeldt M; Holm T; Nielsen HH; Dissing-Olesen L; Toft-Hansen H; Millward JM; Landmann R; Rivest S; Finsen B; Owens T. 2006. Toll-like receptor 2 signaling in response to brain injury: an innate bridge to neuroinflammation. J Neurosci 26(49):12826-37. [PubMed: 17151286]  [MGI Ref ID J:116760]

Babelova A; Moreth K; Tsalastra-Greul W; Zeng-Brouwers J; Eickelberg O; Young MF; Bruckner P; Pfeilschifter J; Schaefer RM; Grone HJ; Schaefer L. 2009. Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors. J Biol Chem 284(36):24035-48. [PubMed: 19605353]  [MGI Ref ID J:155256]

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Bandukwala HS; Clay BS; Tong J; Mody PD; Cannon JL; Shilling RA; Verbeek JS; Weinstock JV; Solway J; Sperling AI. 2007. Signaling through Fc gamma RIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation. J Exp Med 204(8):1875-89. [PubMed: 17664287]  [MGI Ref ID J:125951]

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Barsness KA; Arcaroli J; Harken AH; Abraham E; Banerjee A; Reznikov L; McIntyre RC. 2004. Hemorrhage-induced acute lung injury is TLR-4 dependent. Am J Physiol Regul Integr Comp Physiol 287(3):R592-9. [PubMed: 15072965]  [MGI Ref ID J:95788]

Basu S; Kang TJ; Chen WH; Fenton MJ; Baillie L; Hibbs S; Cross AS. 2007. Role of Bacillus anthracis spore structures in macrophage cytokine responses. Infect Immun 75(5):2351-8. [PubMed: 17339355]  [MGI Ref ID J:121885]

Bauer AK; Dixon D; DeGraff LM; Cho HY; Walker CR; Malkinson AM; Kleeberger SR. 2005. Toll-like receptor 4 in butylated hydroxytoluene-induced mouse pulmonary inflammation and tumorigenesis. J Natl Cancer Inst 97(23):1778-81. [PubMed: 16333033]  [MGI Ref ID J:104658]

Baumgarten G; Knuefermann P; Nozaki N; Sivasubramanian N; Mann DL; Vallejo JG. 2001. In vivo expression of proinflammatory mediators in the adult heart after endotoxin administration: the role of toll-like receptor-4. J Infect Dis 183(11):1617-24. [PubMed: 11343210]  [MGI Ref ID J:120520]

Benjamin JT; Carver BJ; Plosa EJ; Yamamoto Y; Miller JD; Liu JH; van der Meer R; Blackwell TS; Prince LS. 2010. NF-kappaB activation limits airway branching through inhibition of Sp1-mediated fibroblast growth factor-10 expression. J Immunol 185(8):4896-903. [PubMed: 20861353]  [MGI Ref ID J:164723]

Berguer PM; Mundinano J; Piazzon I; Goldbaum FA. 2006. A polymeric bacterial protein activates dendritic cells via TLR4. J Immunol 176(4):2366-72. [PubMed: 16455994]  [MGI Ref ID J:129193]

Bhan U; Ballinger MN; Zeng X; Newstead MJ; Cornicelli MD; Standiford TJ. 2010. Cooperative interactions between TLR4 and TLR9 regulate interleukin 23 and 17 production in a murine model of gram negative bacterial pneumonia. PLoS One 5(3):e9896. [PubMed: 20360853]  [MGI Ref ID J:158954]

Bhattacharyya S; Kelley K; Melichian DS; Tamaki Z; Fang F; Su Y; Feng G; Pope RM; Budinger GR; Mutlu GM; Lafyatis R; Radstake T; Feghali-Bostwick C; Varga J. 2013. Toll-like receptor 4 signaling augments transforming growth factor-beta responses: a novel mechanism for maintaining and amplifying fibrosis in scleroderma. Am J Pathol 182(1):192-205. [PubMed: 23141927]  [MGI Ref ID J:192234]

Bou Ghanem EN; McElroy DS; D'Orazio SE. 2009. Multiple mechanisms contribute to the robust rapid gamma interferon response by CD8+ T cells during Listeria monocytogenes infection. Infect Immun 77(4):1492-501. [PubMed: 19179413]  [MGI Ref ID J:147169]

Braedel S; Radsak M; Einsele H; Latge JP; Michan A; Loeffler J; Haddad Z; Grigoleit U; Schild H; Hebart H. 2004. Aspergillus fumigatus antigens activate innate immune cells via toll-like receptors 2 and 4. Br J Haematol 125(3):392-9. [PubMed: 15086422]  [MGI Ref ID J:89264]

Branger J; Knapp S; Weijer S; Leemans JC; Pater JM; Speelman P; Florquin S; van der Poll T. 2004. Role of Toll-like receptor 4 in gram-positive and gram-negative pneumonia in mice. Infect Immun 72(2):788-94. [PubMed: 14742522]  [MGI Ref ID J:87807]

Buchholz BM; Billiar TR; Bauer AJ. 2010. Dominant role of the MyD88-dependent signaling pathway in mediating early endotoxin-induced murine ileus. Am J Physiol Gastrointest Liver Physiol 299(2):G531-8. [PubMed: 20508155]  [MGI Ref ID J:163354]

Buchholz BM; Chanthaphavong RS; Bauer AJ. 2009. Nonhemopoietic cell TLR4 signaling is critical in causing early lipopolysaccharide-induced ileus. J Immunol 183(10):6744-53. [PubMed: 19846874]  [MGI Ref ID J:157181]

Bunt SK; Clements VK; Hanson EM; Sinha P; Ostrand-Rosenberg S. 2009. Inflammation enhances myeloid-derived suppressor cell cross-talk by signaling through Toll-like receptor 4. J Leukoc Biol 85(6):996-1004. [PubMed: 19261929]  [MGI Ref ID J:149766]

Burch LH; Yang IV; Whitehead GS; Chao FG; Berman KG; Schwartz DA. 2006. The transcriptional response to lipopolysaccharide reveals a role for interferon-gamma in lung neutrophil recruitment. Am J Physiol Lung Cell Mol Physiol 291(4):L677-82. [PubMed: 16766576]  [MGI Ref ID J:144404]

Cabanski M; Steinmuller M; Marsh LM; Surdziel E; Seeger W; Lohmeyer J. 2008. PKR regulates TLR2/TLR4-dependent signaling in murine alveolar macrophages. Am J Respir Cell Mol Biol 38(1):26-31. [PubMed: 17690330]  [MGI Ref ID J:142999]

Campos MA; Rosinha GM; Almeida IC; Salgueiro XS; Jarvis BW; Splitter GA; Qureshi N; Bruna-Romero O; Gazzinelli RT; Oliveira SC. 2004. Role of Toll-like receptor 4 in induction of cell-mediated immunity and resistance to Brucella abortus infection in mice. Infect Immun 72(1):176-86. [PubMed: 14688095]  [MGI Ref ID J:87836]

Canale-Zambrano JC; Auger ML; Haston CK. 2010. Toll-like receptor-4 genotype influences the survival of cystic fibrosis mice. Am J Physiol Gastrointest Liver Physiol 299(2):G381-90. [PubMed: 20522639]  [MGI Ref ID J:163347]

Cao CX; Yang QW; Lv FL; Cui J; Fu HB; Wang JZ. 2007. Reduced cerebral ischemia-reperfusion injury in Toll-like receptor 4 deficient mice. Biochem Biophys Res Commun 353(2):509-14. [PubMed: 17188246]  [MGI Ref ID J:117223]

Carmona J; Cruz A; Moreira-Teixeira L; Sousa C; Sousa J; Osorio NS; Saraiva AL; Svenson S; Kallenius G; Pedrosa J; Rodrigues F; Castro AG; Saraiva M. 2013. Strains Are Differentially Recognized by TLRs with an Impact on the Immune Response. PLoS One 8(6):e67277. [PubMed: 23840651]  [MGI Ref ID J:203717]

Caso JR; Pradillo JM; Hurtado O; Lorenzo P; Moro MA; Lizasoain I. 2007. Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke. Circulation 115(12):1599-608. [PubMed: 17372179]  [MGI Ref ID J:133065]

Cenedeze MA; Goncalves GM; Feitoza CQ; Wang PM; Damiao MJ; Bertocchi AP; Pacheco-Silva A; Camara NO. 2007. The role of toll-like receptor 4 in cisplatin-induced renal injury. Transplant Proc 39(2):409-11. [PubMed: 17362743]  [MGI Ref ID J:124472]

Chapes SK; Mosier DA; Wright AD; Hart ML. 2001. MHCII, Tlr4 and Nramp1 genes control host pulmonary resistance against the opportunistic bacterium Pasteurella pneumotropica. J Leukoc Biol 69(3):381-6. [PubMed: 11261784]  [MGI Ref ID J:69552]

Chassin C; Goujon JM; Darche S; du Merle L; Bens M; Cluzeaud F; Werts C; Ogier-Denis E; Le Bouguenec C; Buzoni-Gatel D; Vandewalle A. 2006. Renal collecting duct epithelial cells react to pyelonephritis-associated Escherichia coli by activating distinct TLR4-dependent and -independent inflammatory pathways. J Immunol 177(7):4773-84. [PubMed: 16982918]  [MGI Ref ID J:139309]

Chen L; Guo S; Ranzer MJ; DiPietro LA. 2013. Toll-like receptor 4 has an essential role in early skin wound healing. Erratum 2014 page 583 J Invest Dermatol 133(1):258-67. [PubMed: 22951730]  [MGI Ref ID J:196482]

Choi SH; Harkewicz R; Lee JH; Boullier A; Almazan F; Li AC; Witztum JL; Bae YS; Miller YI. 2009. Lipoprotein accumulation in macrophages via toll-like receptor-4-dependent fluid phase uptake. Circ Res 104(12):1355-63. [PubMed: 19461045]  [MGI Ref ID J:164760]

Chung YW; Choi JH; Oh TY; Eun CS; Han DS. 2008. Lactobacillus casei prevents the development of dextran sulphate sodium-induced colitis in Toll-like receptor 4 mutant mice. Clin Exp Immunol 151(1):182-9. [PubMed: 18005362]  [MGI Ref ID J:130145]

Cole BC; Mu HH; Pennock ND; Hasebe A; Chan FV; Washburn LR; Peltier MR. 2005. Isolation and partial purification of macrophage- and dendritic cell-activating components from Mycoplasma arthritidis: association with organism virulence and involvement with Toll-like receptor 2. Infect Immun 73(9):6039-47. [PubMed: 16113324]  [MGI Ref ID J:100413]

Constante M; Wang D; Raymond VA; Bilodeau M; Santos MM. 2007. Repression of repulsive guidance molecule C during inflammation is independent of Hfe and involves tumor necrosis factor-alpha. Am J Pathol 170(2):497-504. [PubMed: 17255318]  [MGI Ref ID J:117889]

Coutinho A; Moller G; Gronowicz E. 1975. Genetical control of B-cell responses. IV. Inheritance of the unresponsiveness to lipopolysaccharides. J Exp Med 142(1):253-8. [PubMed: 1097575]  [MGI Ref ID J:5557]

Cunningham PN; Wang Y; Guo R; He G; Quigg RJ. 2004. Role of Toll-like receptor 4 in endotoxin-induced acute renal failure. J Immunol 172(4):2629-35. [PubMed: 14764737]  [MGI Ref ID J:88059]

Curran CS; Demick KP; Mansfield JM. 2006. Lactoferrin activates macrophages via TLR4-dependent and -independent signaling pathways. Cell Immunol 242(1):23-30. [PubMed: 17034774]  [MGI Ref ID J:116741]

D'Avila H; Melo RC; Parreira GG; Werneck-Barroso E; Castro-Faria-Neto HC; Bozza PT. 2006. Mycobacterium bovis bacillus Calmette-Guerin induces TLR2-mediated formation of lipid bodies: intracellular domains for eicosanoid synthesis in vivo. J Immunol 176(5):3087-97. [PubMed: 16493068]  [MGI Ref ID J:129415]

Da Costa CU; Wantia N; Kirschning CJ; Busch DH; Rodriguez N; Wagner H; Miethke T. 2004. Heat shock protein 60 from Chlamydia pneumoniae elicits an unusual set of inflammatory responses via Toll-like receptor 2 and 4 in vivo. Eur J Immunol 34(10):2874. [PubMed: 15368304]  [MGI Ref ID J:92331]

Dabbagh K; Dahl ME; Stepick-Biek P; Lewis DB. 2002. Toll-like receptor 4 is required for optimal development of Th2 immune responses: role of dendritic cells. J Immunol 168(9):4524-30. [PubMed: 11970998]  [MGI Ref ID J:113992]

De Filippo K; Henderson RB; Laschinger M; Hogg N. 2008. Neutrophil Chemokines KC and Macrophage-Inflammatory Protein-2 Are Newly Synthesized by Tissue Macrophages Using Distinct TLR Signaling Pathways. J Immunol 180(6):4308-15. [PubMed: 18322244]  [MGI Ref ID J:132950]

De Nardo D; Labzin LI; Kono H; Seki R; Schmidt SV; Beyer M; Xu D; Zimmer S; Lahrmann C; Schildberg FA; Vogelhuber J; Kraut M; Ulas T; Kerksiek A; Krebs W; Bode N; Grebe A; Fitzgerald ML; Hernandez NJ; Williams BR; Knolle P; Kneilling M; Rocken M; Lutjohann D; Wright SD; Schultze JL; Latz E. 2014. High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3. Nat Immunol 15(2):152-60. [PubMed: 24317040]  [MGI Ref ID J:209298]

Dear JW; Yasuda H; Hu X; Hieny S; Yuen PS; Hewitt SM; Sher A; Star RA. 2006. Sepsis-induced organ failure is mediated by different pathways in the kidney and liver: acute renal failure is dependent on MyD88 but not renal cell apoptosis. Kidney Int 69(5):832-6. [PubMed: 16518342]  [MGI Ref ID J:136506]

Delano MJ; Kelly-Scumpia KM; Thayer TC; Winfield RD; Scumpia PO; Cuenca AG; Harrington PB; O'Malley KA; Warner E; Gabrilovich S; Mathews CE; Laface D; Heyworth PG; Ramphal R; Strieter RM; Moldawer LL; Efron PA. 2011. Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling. J Immunol 187(2):911-8. [PubMed: 21690321]  [MGI Ref ID J:178027]

Dillon LM; Hida A; Garcia S; Prolla TA; Moraes CT. 2012. Long-term bezafibrate treatment improves skin and spleen phenotypes of the mtDNA mutator mouse. PLoS One 7(9):e44335. [PubMed: 22962610]  [MGI Ref ID J:191639]

Dugan CM; Fullerton AM; Roth RA; Ganey PE. 2011. Natural killer cells mediate severe liver injury in a murine model of halothane hepatitis. Toxicol Sci 120(2):507-18. [PubMed: 21245496]  [MGI Ref ID J:171014]

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Ehl S; Bischoff R; Ostler T; Vallbracht S; Schulte-Monting J; Poltorak A; Freudenberg M. 2004. The role of Toll-like receptor 4 versus interleukin-12 in immunity to respiratory syncytial virus. Eur J Immunol 34(4):1146-53. [PubMed: 15048726]  [MGI Ref ID J:88878]

Eisenbarth SC; Zhadkevich A; Ranney P; Herrick CA; Bottomly K. 2004. IL-4-dependent Th2 collateral priming to inhaled antigens independent of Toll-like receptor 4 and myeloid differentiation factor 88. J Immunol 172(7):4527-34. [PubMed: 15034070]  [MGI Ref ID J:88724]

Fairweather D; Yusung S; Frisancho S; Barrett M; Gatewood S; Steele R; Rose NR. 2003. IL-12 Receptor beta1 and Toll-Like Receptor 4 Increase IL-1beta- and IL-18-Associated Myocarditis and Coxsackievirus Replication. J Immunol 170(9):4731-7. [PubMed: 12707353]  [MGI Ref ID J:83020]

Fei M; Bhatia S; Oriss TB; Yarlagadda M; Khare A; Akira S; Saijo S; Iwakura Y; Fallert Junecko BA; Reinhart TA; Foreman O; Ray P; Kolls J; Ray A. 2011. TNF-{alpha} from inflammatory dendritic cells (DCs) regulates lung IL-17A/IL-5 levels and neutrophilia versus eosinophilia during persistent fungal infection. Proc Natl Acad Sci U S A 108(13):5360-5. [PubMed: 21402950]  [MGI Ref ID J:171233]

Frendeus B; Godaly G; Hang L; Karpman D; Svanborg C. 2001. Interleukin-8 receptor deficiency confers susceptibility to acute pyelonephritis. J Infect Dis 183 Suppl 1:S56-60. [PubMed: 11171016]  [MGI Ref ID J:120023]

Frink M; Hsieh YC; Thobe BM; Choudhry MA; Schwacha MG; Bland KI; Chaudry IH. 2007. TLR4 regulates Kupffer cell chemokine production, systemic inflammation and lung neutrophil infiltration following trauma-hemorrhage. Mol Immunol 44(10):2625-30. [PubMed: 17239439]  [MGI Ref ID J:118691]

Frisancho-Kiss S; Davis SE; Nyland JF; Frisancho JA; Cihakova D; Barrett MA; Rose NR; Fairweather D. 2007. Cutting edge: cross-regulation by TLR4 and T cell Ig mucin-3 determines sex differences in inflammatory heart disease. J Immunol 178(11):6710-4. [PubMed: 17513715]  [MGI Ref ID J:147853]

Frisard MI; McMillan RP; Marchand J; Wahlberg KA; Wu Y; Voelker KA; Heilbronn L; Haynie K; Muoio B; Li L; Hulver MW. 2010. Toll-like receptor 4 modulates skeletal muscle substrate metabolism. Am J Physiol Endocrinol Metab 298(5):E988-98. [PubMed: 20179247]  [MGI Ref ID J:162884]

Gangloff SC; Zahringer U; Blondin C; Guenounou M; Silver J; Goyert SM. 2005. Influence of CD14 on ligand interactions between lipopolysaccharide and its receptor complex. J Immunol 175(6):3940-5. [PubMed: 16148141]  [MGI Ref ID J:116691]

Ganta RR; Wilkerson MJ; Cheng C; Rokey AM; Chapes SK. 2002. Persistent Ehrlichia chaffeensis infection occurs in the absence of functional major histocompatibility complex class II genes. Infect Immun 70(1):380-8. [PubMed: 11748204]  [MGI Ref ID J:74569]

Gao C; Kozlowska A; Nechaev S; Li H; Zhang Q; Hossain DM; Kowolik CM; Chu P; Swiderski P; Diamond DJ; Pal SK; Raubitschek A; Kortylewski M. 2013. TLR9 signaling in the tumor microenvironment initiates cancer recurrence after radiotherapy. Cancer Res 73(24):7211-21. [PubMed: 24154870]  [MGI Ref ID J:206520]

Geisel J; Kahl F; Muller M; Wagner H; Kirschning CJ; Autenrieth IB; Frick JS. 2007. IL-6 and maturation govern TLR2 and TLR4 induced TLR agonist tolerance and cross-tolerance in dendritic cells. J Immunol 179(9):5811-8. [PubMed: 17947654]  [MGI Ref ID J:153008]

Geisel RE; Sakamoto K; Russell DG; Rhoades ER. 2005. In vivo activity of released cell wall lipids of Mycobacterium bovis bacillus Calmette-Guerin is due principally to trehalose mycolates. J Immunol 174(8):5007-15. [PubMed: 15814731]  [MGI Ref ID J:98152]

Georgel P; Jiang Z; Kunz S; Janssen E; Mols J; Hoebe K; Bahram S; Oldstone MB; Beutler B. 2007. Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway. Virology 362(2):304-13. [PubMed: 17292937]  [MGI Ref ID J:124488]

Giangreco A; Hoste E; Takai Y; Rosewell I; Watt FM. 2012. Epidermal Cadm1 expression promotes autoimmune alopecia via enhanced T cell adhesion and cytotoxicity. J Immunol 188(3):1514-22. [PubMed: 22210910]  [MGI Ref ID J:180748]

Glickstein LJ; Coburn JL. 2006. Short report: Association of macrophage inflammatory response and cell death after in vitro Borrelia burgdorferi infection with arthritis resistance. Am J Trop Med Hyg 75(5):964-7. [PubMed: 17123997]  [MGI Ref ID J:135947]

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Steiner AA; Chakravarty S; Rudaya AY; Herkenham M; Romanovsky AA. 2006. Bacterial lipopolysaccharide fever is initiated via Toll-like receptor 4 on hematopoietic cells. Blood 107(10):4000-2. [PubMed: 16403908]  [MGI Ref ID J:132740]

Stewart PW; Chapes SK. 2003. Role of major histocompatibility complex class II in resistance of mice to naturally acquired infection with Syphacia obvelata. Comp Med 53(1):70-4. [PubMed: 12625509]  [MGI Ref ID J:82325]

Suganami T; Mieda T; Itoh M; Shimoda Y; Kamei Y; Ogawa Y. 2007. Attenuation of obesity-induced adipose tissue inflammation in C3H/HeJ mice carrying a Toll-like receptor 4 mutation. Biochem Biophys Res Commun 354(1):45-9. [PubMed: 17210129]  [MGI Ref ID J:117843]

Suganami T; Yuan X; Shimoda Y; Uchio-Yamada K; Nakagawa N; Shirakawa I; Usami T; Tsukahara T; Nakayama K; Miyamoto Y; Yasuda K; Matsuda J; Kamei Y; Kitajima S; Ogawa Y. 2009. Activating transcription factor 3 constitutes a negative feedback mechanism that attenuates saturated Fatty acid/toll-like receptor 4 signaling and macrophage activation in obese adipose tissue. Circ Res 105(1):25-32. [PubMed: 19478204]  [MGI Ref ID J:164755]

Suhs KA; Marthaler BR; Welch RA; Hopkins WJ. 2011. Lack of association between the Tlr4 (Lpsd/Lpsd) genotype and increased susceptibility to Escherichia coli bladder infections in female C3H/HeJ mice. MBio 2(3):e00094-11. [PubMed: 21628500]  [MGI Ref ID J:182202]

Sun Y; Karmakar M; Roy S; Ramadan RT; Williams SR; Howell S; Shive CL; Han Y; Stopford CM; Rietsch A; Pearlman E. 2010. TLR4 and TLR5 on corneal macrophages regulate Pseudomonas aeruginosa keratitis by signaling through MyD88-dependent and -independent pathways. J Immunol 185(7):4272-83. [PubMed: 20826748]  [MGI Ref ID J:164286]

Suram S; Silveira LJ; Mahaffey S; Brown GD; Bonventre JV; Williams DL; Gow NA; Bratton DL; Murphy RC; Leslie CC. 2013. Cytosolic phospholipase A(2)alpha and eicosanoids regulate expression of genes in macrophages involved in host defense and inflammation. PLoS One 8(7):e69002. [PubMed: 23950842]  [MGI Ref ID J:204931]

Suzuki M; Nakano K. 1996. Increase in histamine synthesis by liver macrophages in CCl4-injured mast cell-deficient W/Wv mice. Biochem Pharmacol 52(5):809-13. [PubMed: 8765479]  [MGI Ref ID J:35601]

Tagliabue A; McCoy JL; Herberman RB. 1978. Refractoriness to migration inhibitory factor of macrophages of LPS nonresponder mouse strains. J Immunol 121(4):1223-6. [PubMed: 359704]  [MGI Ref ID J:6043]

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Tan AM; Chen HC; Pochard P; Eisenbarth SC; Herrick CA; Bottomly HK. 2010. TLR4 signaling in stromal cells is critical for the initiation of allergic Th2 responses to inhaled antigen. J Immunol 184(7):3535-44. [PubMed: 20194715]  [MGI Ref ID J:160085]

Tang SC; Arumugam TV; Xu X; Cheng A; Mughal MR; Jo DG; Lathia JD; Siler DA; Chigurupati S; Ouyang X; Magnus T; Camandola S; Mattson MP. 2007. Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits. Proc Natl Acad Sci U S A 104(34):13798-803. [PubMed: 17693552]  [MGI Ref ID J:124100]

Tang SC; Lathia JD; Selvaraj PK; Jo DG; Mughal MR; Cheng A; Siler DA; Markesbery WR; Arumugam TV; Mattson MP. 2008. Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid beta-peptide and the membrane lipid peroxidation product 4-hydroxynonenal. Exp Neurol 213(1):114-21. [PubMed: 18586243]  [MGI Ref ID J:138608]

Tanga FY; Nutile-McMenemy N; Deleo JA. 2005. The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy. Proc Natl Acad Sci U S A 102(16):5856-61. [PubMed: 15809417]  [MGI Ref ID J:97819]

Tavener SA; Long EM; Robbins SM; McRae KM; Van Remmen H; Kubes P. 2004. Immune cell Toll-like receptor 4 is required for cardiac myocyte impairment during endotoxemia. Circ Res 95(7):700-7. [PubMed: 15358664]  [MGI Ref ID J:101491]

Taylor KR; Yamasaki K; Radek KA; Di Nardo A; Goodarzi H; Golenbock D; Beutler B; Gallo RL. 2007. Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2. J Biol Chem 282(25):18265-75. [PubMed: 17400552]  [MGI Ref ID J:123387]

Thaete LG; Qu XW; Jilling T; Crawford SE; Fitchev P; Hirsch E; Khan S; Neerhof MG. 2013. Impact of toll-like receptor 4 deficiency on the response to uterine ischemia/reperfusion in mice. Reproduction 145(5):517-26. [PubMed: 23509372]  [MGI Ref ID J:197922]

Thomas JA; Tsen MF; White DJ; Horton JW. 2002. TLR4 inactivation and rBPI(21) block burn-induced myocardial contractile dysfunction. Am J Physiol Heart Circ Physiol 283(4):H1645-55. [PubMed: 12234819]  [MGI Ref ID J:108049]

Timmers L; Sluijter JP; van Keulen JK; Hoefer IE; Nederhoff MG; Goumans MJ; Doevendans PA; van Echteld CJ; Joles JA; Quax PH; Piek JJ; Pasterkamp G; de Kleijn DP. 2008. Toll-like receptor 4 mediates maladaptive left ventricular remodeling and impairs cardiac function after myocardial infarction. Circ Res 102(2):257-64. [PubMed: 18007026]  [MGI Ref ID J:145592]

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Treml LS; Carlesso G; Hoek KL; Stadanlick JE; Kambayashi T; Bram RJ; Cancro MP; Khan WN. 2007. TLR stimulation modifies BLyS receptor expression in follicular and marginal zone B cells. J Immunol 178(12):7531-9. [PubMed: 17548587]  [MGI Ref ID J:148596]

Tsukumo DM; Carvalho-Filho MA; Carvalheira JB; Prada PO; Hirabara SM; Schenka AA; Araujo EP; Vassallo J; Curi R; Velloso LA; Saad MJ. 2007. Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 56(8):1986-98. [PubMed: 17519423]  [MGI Ref ID J:126488]

Tsung A; Hoffman RA; Izuishi K; Critchlow ND; Nakao A; Chan MH; Lotze MT; Geller DA; Billiar TR. 2005. Hepatic ischemia/reperfusion injury involves functional TLR4 signaling in nonparenchymal cells. J Immunol 175(11):7661-8. [PubMed: 16301676]  [MGI Ref ID J:122164]

Tsung A; Klune JR; Zhang X; Jeyabalan G; Cao Z; Peng X; Stolz DB; Geller DA; Rosengart MR; Billiar TR. 2007. HMGB1 release induced by liver ischemia involves Toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling. J Exp Med 204(12):2913-23. [PubMed: 17984303]  [MGI Ref ID J:128522]

Tsung A; Sahai R; Tanaka H; Nakao A; Fink MP; Lotze MT; Yang H; Li J; Tracey KJ; Geller DA; Billiar TR. 2005. The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J Exp Med 201(7):1135-43. [PubMed: 15795240]  [MGI Ref ID J:98036]

Tsung A; Zheng N; Jeyabalan G; Izuishi K; Klune JR; Geller DA; Lotze MT; Lu L; Billiar TR. 2007. Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury. J Leukoc Biol 81(1):119-28. [PubMed: 17062605]  [MGI Ref ID J:117230]

Vazquez-Torres A; Vallance BA; Bergman MA; Finlay BB; Cookson BT; Jones-Carson J; Fang FC. 2004. Toll-like receptor 4 dependence of innate and adaptive immunity to Salmonella: importance of the Kupffer cell network. J Immunol 172(10):6202-8. [PubMed: 15128808]  [MGI Ref ID J:89854]

Velazquez P; Wei B; McPherson M; Mendoza LM; Nguyen SL; Turovskaya O; Kronenberg M; Huang TT; Schrage M; Lobato LN; Fujiwara D; Brewer S; Arditi M; Cheng G; Sartor RB; Newberry RD; Braun J. 2008. Villous B cells of the small intestine are specialized for invariant NK T cell dependence. J Immunol 180(7):4629-38. [PubMed: 18354186]  [MGI Ref ID J:133099]

Vogel SN; Johnson D; Perera PY; Medvedev A; Lariviere L; Qureshi ST ; Malo D. 1999. Cutting edge: functional characterization of the effect of the C3H/HeJ defect in mice that lack an Lpsn gene: in vivo evidence for a dominant negative mutation. J Immunol 162(10):5666-70. [PubMed: 10229796]  [MGI Ref ID J:54987]

Vogl T; Tenbrock K; Ludwig S; Leukert N; Ehrhardt C; van Zoelen MA; Nacken W; Foell D; van der Poll T; Sorg C; Roth J. 2007. Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nat Med 13(9):1042-9. [PubMed: 17767165]  [MGI Ref ID J:125179]

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Wang S; Schmaderer C; Kiss E; Schmidt C; Bonrouhi M; Porubsky S; Gretz N; Schaefer L; Kirschning CJ; Popovic ZV; Grone HJ. 2010. Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88- and TRIF-dependent signaling. Dis Model Mech 3(1-2):92-103. [PubMed: 20038715]  [MGI Ref ID J:157656]

Wang X; Moser C; Louboutin JP; Lysenko ES; Weiner DJ; Weiser JN; Wilson JM. 2002. Toll-like receptor 4 mediates innate immune responses to Haemophilus influenzae infection in mouse lung. J Immunol 168(2):810-5. [PubMed: 11777976]  [MGI Ref ID J:73739]

Wang XM; Kim HP; Nakahira K; Ryter SW; Choi AM. 2009. The heme oxygenase-1/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1. J Immunol 182(6):3809-18. [PubMed: 19265160]  [MGI Ref ID J:145914]

Wang Y; Han G; Wang K; Liu G; Wang R; Xiao H; Li X; Hou C; Shen B; Guo R; Li Y; Chen G. 2014. Tumor-derived GM-CSF promotes inflammatory colon carcinogenesis via stimulating epithelial release of VEGF. Cancer Res 74(3):716-26. [PubMed: 24366884]  [MGI Ref ID J:208169]

Wang ZY; Yang D; Chen Q; Leifer CA; Segal DM; Su SB; Caspi RR; Howard ZO; Oppenheim JJ. 2006. Induction of dendritic cell maturation by pertussis toxin and its B subunit differentially initiate Toll-like receptor 4-dependent signal transduction pathways. Exp Hematol 34(8):1115-24. [PubMed: 16863919]  [MGI Ref ID J:111901]

Wantia N; Rodriguez N; Cirl C; Ertl T; Durr S; Layland LE; Wagner H; Miethke T. 2011. Toll-like receptors 2 and 4 regulate the frequency of IFNgamma-producing CD4+ T-cells during pulmonary infection with Chlamydia pneumoniae. PLoS One 6(11):e26101. [PubMed: 22096480]  [MGI Ref ID J:180980]

Warger T; Hilf N; Rechtsteiner G; Haselmayer P; Carrick DM; Jonuleit H; von Landenberg P; Rammensee HG; Nicchitta CV; Radsak MP; Schild H. 2006. Interaction of TLR2 and TLR4 ligands with the N-terminal domain of Gp96 amplifies innate and adaptive immune responses. J Biol Chem 281(32):22545-53. [PubMed: 16754684]  [MGI Ref ID J:116459]

Watson J; Largen M; McAdam KP. 1978. Genetic control of endotoxic responses in mice. J Exp Med 147(1):39-49. [PubMed: 342667]  [MGI Ref ID J:5938]

Weighardt H; Kaiser-Moore S; Vabulas RM; Kirschning CJ; Wagner H; Holzmann B. 2002. Cutting edge: myeloid differentiation factor 88 deficiency improves resistance against sepsis caused by polymicrobial infection. J Immunol 169(6):2823-7. [PubMed: 12218091]  [MGI Ref ID J:120435]

Whitaker SM; Colmenares M; Pestana KG; McMahon-Pratt D. 2008. Leishmania pifanoi proteoglycolipid complex P8 induces macrophage cytokine production through Toll-like receptor 4. Infect Immun 76(5):2149-56. [PubMed: 18299340]  [MGI Ref ID J:134478]

Wong PM; Kang A; Chen H; Yuan Q; Fan P; Sultzer BM; Kan YW; Chung SW. 1999. Lps(d)/Ran of endotoxin-resistant C3H/HeJ mice is defective in mediating lipopolysaccharide endotoxin responses. Proc Natl Acad Sci U S A 96(20):11543-8. [PubMed: 10500213]  [MGI Ref ID J:57938]

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Wu SC; Yang JC; Rau CS; Chen YC; Lu TH; Lin MW; Tzeng SL; Wu YC; Wu CJ; Hsieh CH. 2013. Profiling circulating microRNA expression in experimental sepsis using cecal ligation and puncture. PLoS One 8(10):e77936. [PubMed: 24205035]  [MGI Ref ID J:209241]

Xiang M; Yin L; Li Y; Xiao G; Vodovotz Y; Billiar TR; Wilson MA; Fan J. 2011. Hemorrhagic shock activates lung endothelial reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase via neutrophil NADPH oxidase. Am J Respir Cell Mol Biol 44(3):333-40. [PubMed: 20418360]  [MGI Ref ID J:183358]

Yang HZ; Wang JP; Mi S; Liu HZ; Cui B; Yan HM; Yan J; Li Z; Liu H; Hua F; Lu W; Hu ZW. 2012. TLR4 activity is required in the resolution of pulmonary inflammation and fibrosis after acute and chronic lung injury. Am J Pathol 180(1):275-92. [PubMed: 22062220]  [MGI Ref ID J:180182]

Yang R; Murillo FM; Delannoy MJ; Blosser RL; Yutzy WH 4th; Uematsu S; Takeda K; Akira S; Viscidi RP; Roden RB. 2005. B lymphocyte activation by human papillomavirus-like particles directly induces Ig class switch recombination via TLR4-MyD88. J Immunol 174(12):7912-9. [PubMed: 15944297]  [MGI Ref ID J:100870]

Yang X; Murthy V; Schultz K; Tatro JB; Fitzgerald KA; Beasley D. 2006. Toll-like receptor 3 signaling evokes a proinflammatory and proliferative phenotype in human vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 291(5):H2334-43. [PubMed: 16782847]  [MGI Ref ID J:116310]

Yano J; Palmer GE; Eberle KE; Peters BM; Vogl T; McKenzie AN; Fidel PL Jr. 2014. Vaginal epithelial cell-derived S100 alarmins induced by Candida albicans via pattern recognition receptor interactions are sufficient but not necessary for the acute neutrophil response during experimental vaginal candidiasis. Infect Immun 82(2):783-92. [PubMed: 24478092]  [MGI Ref ID J:209808]

Yao C; Purwanti N; Karabasil MR; Azlina A; Javkhlan P; Hasegawa T; Akamatsu T; Hosoi T; Ozawa K; Hosoi K. 2010. Potential down-regulation of salivary gland AQP5 by LPS via cross-coupling of NF-kappaB and p-c-Jun/c-Fos. Am J Pathol 177(2):724-34. [PubMed: 20522648]  [MGI Ref ID J:163414]

Yohe HC; O'Hara KA; Hunt JA; Kitzmiller TJ; Wood SG; Bement JL; Bement WJ; Szakacs JG; Wrighton SA; Jacobs JM; Kostrubsky V; Sinclair PR; Sinclair JF. 2006. Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity. Am J Physiol Gastrointest Liver Physiol 290(6):G1269-79. [PubMed: 16439473]  [MGI Ref ID J:111091]

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Yu FS; Cornicelli MD; Kovach MA; Newstead MW; Zeng X; Kumar A; Gao N; Yoon SG; Gallo RL; Standiford TJ. 2010. Flagellin stimulates protective lung mucosal immunity: role of cathelicidin-related antimicrobial peptide. J Immunol 185(2):1142-9. [PubMed: 20566829]  [MGI Ref ID J:162021]

Yu H; Ha T; Liu L; Wang X; Gao M; Kelley J; Kao R; Williams D; Li C. 2012. Scavenger receptor A (SR-A) is required for LPS-induced TLR4 mediated NF-kappaB activation in macrophages. Biochim Biophys Acta 1823(7):1192-8. [PubMed: 22627090]  [MGI Ref ID J:185204]

Yusuf N; Nasti TH; Long JA; Naseemuddin M; Lucas AP; Xu H; Elmets CA. 2008. Protective role of Toll-like receptor 4 during the initiation stage of cutaneous chemical carcinogenesis. Cancer Res 68(2):615-22. [PubMed: 18199559]  [MGI Ref ID J:131415]

Yvan-Charvet L; Welch C; Pagler TA; Ranalletta M; Lamkanfi M; Han S; Ishibashi M; Li R; Wang N; Tall AR. 2008. Increased inflammatory gene expression in ABC transporter-deficient macrophages: free cholesterol accumulation, increased signaling via toll-like receptors, and neutrophil infiltration of atherosclerotic lesions. Circulation 118(18):1837-47. [PubMed: 18852364]  [MGI Ref ID J:165622]

Zamboni DS; Campos MA; Torrecilhas AC; Kiss K; Samuel JE; Golenbock DT; Lauw FN; Roy CR; Almeida IC; Gazzinelli RT. 2004. Stimulation of toll-like receptor 2 by Coxiella burnetii is required for macrophage production of pro-inflammatory cytokines and resistance to infection. J Biol Chem 279(52):54405-15. [PubMed: 15485838]  [MGI Ref ID J:95155]

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Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, homozygous mice may be bred together.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing


Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2625.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $1725.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing


Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3412.50
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2242.50

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

  • View the complete collection of spontaneous mutants in the Mouse Mutant Resource.

Control Information

   See control note: This strain is a control for 004326 and 003968.
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

Important Note

This strain is homozygous for Pde6brd1 and Tlr4Lps-d.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty


In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.