Strain Name:

B6.129S2(C)-Stat6tm1Gru/J

Stock Number:

005977

Order this mouse

Availability:

Repository- Live

Use Restrictions Apply, see Terms of Use
Lymphocytes from Stat6 knock-out mice fail to proliferate in response to IL-4, and have a defective IgE response following in vivo immunization with anti-IgD. These mice may be useful in studies of Th2 cell differentiation, Th2-mediated diseases, asthma, cytokine/chemokine function, signal transduction and transcription factors, and diseases of the central nervous system such as multiple sclerosis.

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   12-JUN-06
Specieslaboratory mouse
GenerationN11+N1F3 (16-DEC-13)
Generation Definitions
 
Donating Investigator Samia J Khoury,   Harvard Medical School

Description
Homozygous mice are viable and fertile with no behavioral abnormalities. Homozygotes do not express the endogenous protein in thymus and peripheral lymphoid organs. In contrast to controls, IL-4 treated lymphocytes show no induction of MHC class II or IL-4 receptor genes and have severly impaired proliferative responses. Further, homozygous mice have a defective IgE response. While T-helper 1 (Th1) cell differentiation is unimpaired in homozygous splenocytes, Th2 cell differentiation is almost completely abrogated despite IL-4 or IL-13 incubation. Myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) is more severe in homozygous mice compared to wildtype. This mouse may be useful in studies of Th2 cell differentiation, Th2-mediated diseases, asthma, cytokine/chemokine function, signal transduction and transcription factors, and diseases of the central nervous system such as multiple sclerosis.

Development
A targeting vector containing a neomycin resistance cassette was used to replace the region of the endogenous gene that encodes amino acids 505-584 (SH2 domain required for dimerization). The construct was electroporated into 129S2/SvPas-derived D3 embryonic stem (ES) cells. Correctly targeted ES cells were injected into BALB/c blastocysts. The resulting chimeric animals were bred to BALB/c mice and maintained on that background for an unknown number of generations. The donating investigator reported that these mutant mice were then mated to C57BL/6J (see SNP note below) for at least 10 generations before arrival at The Jackson Laboratory.

A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, 3 of 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to The Jackson Laboratory Repository were on a mixed C57BL/6J ; C57BL/6N genetic background.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Stat6tm1Gru allele
003750   C.129S2-Stat4tm1Gru Stat6tm1Gru/J
002828   C.129S2-Stat6tm1Gru/J
004672   NOD.129S2(Cg)-Stat6tm1Gru/JbsJ
View Strains carrying   Stat6tm1Gru     (3 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Stat6tm1Gru/Stat6tm1Gru

        C.129S2-Stat6tm1Gru/J
  • immune system phenotype
  • abnormal CD4-positive T cell differentiation
    • fewer IL4+ and IL9+ cells following differentiation towards Th9 lineage   (MGI Ref ID J:204829)
  • abnormal CD8-positive, alpha beta T cell morphology
    • IL-4 is unable to prevent decreases in CD8 expression during overnight cultures   (MGI Ref ID J:125259)
  • abnormal humoral immune response
    • neutralizing antibody titer higher than control following HSV-1 vaccination   (MGI Ref ID J:107370)
    • decreased IgA level
      • following HSV-1 vaccination   (MGI Ref ID J:107370)
    • decreased IgG3 level
      • decrease in IgG3 level following HSV-1 vaccination   (MGI Ref ID J:107370)
      • IgG2a and IgG2b levels remain similar to control   (MGI Ref ID J:107370)
    • decreased IgM level
      • following HSV-1 vaccination   (MGI Ref ID J:107370)
  • decreased interleukin-4 secretion
    • cultured splenocytes do not secrete IL4 when stimulated   (MGI Ref ID J:107370)
  • decreased susceptibility to viral infection
    • increased clearance of virus following HSV-1 infection as compared to controls   (MGI Ref ID J:107370)
    • reduced susceptibility to corneal scarring and blepharitis following HSV-1 infection as compared to controls   (MGI Ref ID J:107370)
  • increased interferon-gamma secretion
    • HSV-1 vaccinated cultured splenocytes secrete high levels of IFNG without stimulation; control cells secret IFNG only when stimulated   (MGI Ref ID J:107370)
  • increased interleukin-2 secretion
    • cultured splenocytes secrete high levels of IL2 regardless of HSV-1 stimulation or vaccination; control cells secret IL2 only when stimulated and vaccinated   (MGI Ref ID J:107370)
  • hematopoietic system phenotype
  • abnormal CD4-positive T cell differentiation
    • fewer IL4+ and IL9+ cells following differentiation towards Th9 lineage   (MGI Ref ID J:204829)
  • abnormal CD8-positive, alpha beta T cell morphology
    • IL-4 is unable to prevent decreases in CD8 expression during overnight cultures   (MGI Ref ID J:125259)
  • decreased IgA level
    • following HSV-1 vaccination   (MGI Ref ID J:107370)
  • decreased IgG3 level
    • decrease in IgG3 level following HSV-1 vaccination   (MGI Ref ID J:107370)
    • IgG2a and IgG2b levels remain similar to control   (MGI Ref ID J:107370)
  • decreased IgM level
    • following HSV-1 vaccination   (MGI Ref ID J:107370)

Stat6tm1Gru/Stat6tm1Gru

        129S2/SvPas-Stat6tm1Gru
  • immune system phenotype
  • abnormal T-helper 2 cell differentiation
    • impaired ability of T lymphocytes to differentiate into Th2 cells   (MGI Ref ID J:31932)
  • abnormal interleukin secretion
    • spleen cells stimulated with anti-CD3 and cultured with anti-IFNG and IL4 or IL13 do not produce IL4 and IL5   (MGI Ref ID J:31932)
    • decreased interleukin-4 secretion   (MGI Ref ID J:31932)
    • decreased interleukin-5 secretion   (MGI Ref ID J:31932)
  • decreased IgE level
    • anti-IgD immunized mice do not show an increase in IgE levels although IgG1 and IgG2a levels increase similar to wildtype sera levels   (MGI Ref ID J:31932)
  • decreased T cell proliferation
    • IL4 stimulated lymph node cells exhibit an impaired proliferative response   (MGI Ref ID J:31932)
  • hematopoietic system phenotype
  • abnormal T-helper 2 cell differentiation
    • impaired ability of T lymphocytes to differentiate into Th2 cells   (MGI Ref ID J:31932)
  • decreased IgE level
    • anti-IgD immunized mice do not show an increase in IgE levels although IgG1 and IgG2a levels increase similar to wildtype sera levels   (MGI Ref ID J:31932)
  • decreased T cell proliferation
    • IL4 stimulated lymph node cells exhibit an impaired proliferative response   (MGI Ref ID J:31932)

Stat6tm1Gru/Stat6tm1Gru

        involves: 129S2/SvPas
  • immune system phenotype
  • abnormal cytokine secretion
    • T cells from mice immunized with keyhole limpet hemocyanin (KLH) in CFA (conjugated Freund's adjuvant) produce less IL-4 and interferon gamma than wild-type in response to KLH restimulation; IL-17a levels are comparable to controls   (MGI Ref ID J:112600)
  • reproductive system phenotype
  • abnormal mammary gland growth during pregnancy
    • decrease in alveologenesis at 5dG but not at 15dG   (MGI Ref ID J:184505)
  • cellular phenotype
  • decreased mammary gland epithelium proliferation
    • decrease in the proliferative potential of luminal progenitor cells in vitro   (MGI Ref ID J:184505)
  • endocrine/exocrine gland phenotype
  • abnormal mammary gland morphology
    • increase in the population of cells expressing GATA3, ESR1, and PGR and absence of cells expressing STAT5   (MGI Ref ID J:184505)
    • abnormal mammary gland epithelium morphology
      • increase in the number of luminal progenitor cells   (MGI Ref ID J:184505)
    • abnormal mammary gland growth during pregnancy
      • decrease in alveologenesis at 5dG but not at 15dG   (MGI Ref ID J:184505)
  • decreased mammary gland epithelium proliferation
    • decrease in the proliferative potential of luminal progenitor cells in vitro   (MGI Ref ID J:184505)
  • integument phenotype
  • abnormal mammary gland morphology
    • increase in the population of cells expressing GATA3, ESR1, and PGR and absence of cells expressing STAT5   (MGI Ref ID J:184505)
    • abnormal mammary gland epithelium morphology
      • increase in the number of luminal progenitor cells   (MGI Ref ID J:184505)
    • abnormal mammary gland growth during pregnancy
      • decrease in alveologenesis at 5dG but not at 15dG   (MGI Ref ID J:184505)
  • decreased mammary gland epithelium proliferation
    • decrease in the proliferative potential of luminal progenitor cells in vitro   (MGI Ref ID J:184505)

Stat6tm1Gru/Stat6tm1Gru

        involves: 129S2/SvPas * BALB/c
  • homeostasis/metabolism phenotype
  • abnormal circulating alanine transaminase level
    • ConA injection fails to cause elevated alanine aminotransaminase levels as it does in controls   (MGI Ref ID J:85386)
  • increased circulating tumor necrosis factor level
    • serum TNF alpha levels increase 2-3 fold after ConA injection   (MGI Ref ID J:85386)
  • liver/biliary system phenotype
  • *normal* liver/biliary system phenotype
    • liver necrosis fails to develop after ConA injection   (MGI Ref ID J:85386)
  • immune system phenotype
  • *normal* immune system phenotype
    • IL4 levels fail to increase after ConA injection   (MGI Ref ID J:85386)
    • abnormal acute inflammation
      • attenuated neutrophil and eosinophil infiltration of liver after ConA injection compared to controls   (MGI Ref ID J:85386)
    • abnormal granulocyte physiology   (MGI Ref ID J:85386)
      • impaired eosinophil chemotaxis
        • attenuated infiltration of liver after ConA injection compared to controls   (MGI Ref ID J:85386)
      • impaired neutrophil chemotaxis
        • attenuated infiltration of liver after ConA injection compared to controls   (MGI Ref ID J:85386)
    • abnormal macrophage physiology
      • lessened macrophage death after ConA injection compared to controls   (MGI Ref ID J:85386)
    • increased circulating tumor necrosis factor level
      • serum TNF alpha levels increase 2-3 fold after ConA injection   (MGI Ref ID J:85386)
  • endocrine/exocrine gland phenotype
  • abnormal mammary gland growth during pregnancy
    • mammary glands are normal in 5 week old virgin mice   (MGI Ref ID J:124116)
    • reduced side branches and alveolar buds at 5 days of gestation   (MGI Ref ID J:124116)
    • development continues to be delayed at 10 and 15 days of gestation   (MGI Ref ID J:124116)
    • density of lobuloalveolar structures is diminished: reduced 70% at 5 days, 50% at 10 days, 30% at 15 days   (MGI Ref ID J:124116)
  • cellular phenotype
  • impaired eosinophil chemotaxis
    • attenuated infiltration of liver after ConA injection compared to controls   (MGI Ref ID J:85386)
  • impaired neutrophil chemotaxis
    • attenuated infiltration of liver after ConA injection compared to controls   (MGI Ref ID J:85386)
  • integument phenotype
  • abnormal mammary gland growth during pregnancy
    • mammary glands are normal in 5 week old virgin mice   (MGI Ref ID J:124116)
    • reduced side branches and alveolar buds at 5 days of gestation   (MGI Ref ID J:124116)
    • development continues to be delayed at 10 and 15 days of gestation   (MGI Ref ID J:124116)
    • density of lobuloalveolar structures is diminished: reduced 70% at 5 days, 50% at 10 days, 30% at 15 days   (MGI Ref ID J:124116)
  • reproductive system phenotype
  • abnormal mammary gland growth during pregnancy
    • mammary glands are normal in 5 week old virgin mice   (MGI Ref ID J:124116)
    • reduced side branches and alveolar buds at 5 days of gestation   (MGI Ref ID J:124116)
    • development continues to be delayed at 10 and 15 days of gestation   (MGI Ref ID J:124116)
    • density of lobuloalveolar structures is diminished: reduced 70% at 5 days, 50% at 10 days, 30% at 15 days   (MGI Ref ID J:124116)
  • hematopoietic system phenotype
  • abnormal granulocyte physiology   (MGI Ref ID J:85386)
    • impaired eosinophil chemotaxis
      • attenuated infiltration of liver after ConA injection compared to controls   (MGI Ref ID J:85386)
    • impaired neutrophil chemotaxis
      • attenuated infiltration of liver after ConA injection compared to controls   (MGI Ref ID J:85386)
  • abnormal macrophage physiology
    • lessened macrophage death after ConA injection compared to controls   (MGI Ref ID J:85386)

Stat6tm1Gru/Stat6tm1Gru

        C.129S2-Stat6tm1Gru
  • tumorigenesis
  • altered tumor susceptibility
    • growth rate of injected 4T1mouse mammary carcinoma cells is slowed   (MGI Ref ID J:65894)
    • CD8+ cell depletion leads to rapid mammary tumor growth   (MGI Ref ID J:65894)
  • decreased metastatic potential
    • metastasis to lungs of 4T1mammary carcinoma cells is significantly reduced   (MGI Ref ID J:65894)
    • CD8+ cell depletion leads to increased metastasis to lungs   (MGI Ref ID J:65894)
  • immune system phenotype
  • abnormal immune serum protein physiology   (MGI Ref ID J:66222)
    • abnormal circulating interleukin level   (MGI Ref ID J:66222)
      • abnormal circulating interleukin-4 level
        • levels fail to increase after antigen challenge   (MGI Ref ID J:66222)
      • abnormal circulating interleukin-5 level
        • levels fail to increase after antigen challenge   (MGI Ref ID J:66222)
    • abnormal immunoglobulin level   (MGI Ref ID J:66222)
      • decreased IgE level
        • no detectable IgE whether OVA challenged or not   (MGI Ref ID J:66222)
        • chronic Aspergillus fumigatus infection fails to elicit serum IgE   (MGI Ref ID J:74497)
      • decreased IgG1 level
        • reduced OVA specific IgG1   (MGI Ref ID J:66222)
      • increased IgG2a level
        • increased OVA specific IgG2a   (MGI Ref ID J:66222)
  • abnormal leukocyte physiology   (MGI Ref ID J:74497)
    • abnormal cytotoxic T cell physiology
      • develop significant levels of cytotoxic lymphocytes specific for 4T1mouse mammary carcinoma cells   (MGI Ref ID J:65894)
    • abnormal immunoglobulin level   (MGI Ref ID J:66222)
      • decreased IgE level
        • no detectable IgE whether OVA challenged or not   (MGI Ref ID J:66222)
        • chronic Aspergillus fumigatus infection fails to elicit serum IgE   (MGI Ref ID J:74497)
      • decreased IgG1 level
        • reduced OVA specific IgG1   (MGI Ref ID J:66222)
      • increased IgG2a level
        • increased OVA specific IgG2a   (MGI Ref ID J:66222)
    • abnormal leukocyte migration
      • only minor peribronchial leukocyte accumulation in response to chronic Aspergillus fumigatus infection   (MGI Ref ID J:74497)
      • delayed presence of T cells in bronchoalveolar lavage fluid with chronic Aspergillus fumigatus infection   (MGI Ref ID J:74497)
    • impaired eosinophil recruitment
      • fewer eosinophils in bronchoalveolar fluid of OVA sensitized mice than in controls although still elevated   (MGI Ref ID J:66222)
  • respiratory system phenotype
  • abnormal airway responsiveness
    • OVA sensitized mice fail to develop airway hyperresponsiveness in response to acetylcholine   (MGI Ref ID J:66222)
    • airway hyper-responsiveness develops very slowly in response to chronic Aspergillus fumigatus infection compared to controls   (MGI Ref ID J:74497)
  • abnormal respiratory epithelium morphology   (MGI Ref ID J:74497)
    • no increase of mucus in airway epithelial cells with antigen exposure   (MGI Ref ID J:66222)
  • homeostasis/metabolism phenotype
  • abnormal circulating interleukin level   (MGI Ref ID J:66222)
    • abnormal circulating interleukin-4 level
      • levels fail to increase after antigen challenge   (MGI Ref ID J:66222)
    • abnormal circulating interleukin-5 level
      • levels fail to increase after antigen challenge   (MGI Ref ID J:66222)
  • abnormal noradrenaline level
    • noradrenaline content of adipose tissue is reduced 50-60% with cold exposure   (MGI Ref ID J:178294)
  • decreased core body temperature
    • drops when exposed to 4C   (MGI Ref ID J:178294)
  • decreased fatty acid level
    • reduced circulating free fatty acids when exposed to 4C   (MGI Ref ID J:178294)
  • increased circulating creatine level
    • higher levels after kidney ischemia   (MGI Ref ID J:84825)
  • renal/urinary system phenotype
  • abnormal renal tubule morphology   (MGI Ref ID J:84825)
  • cellular phenotype
  • abnormal leukocyte migration
    • only minor peribronchial leukocyte accumulation in response to chronic Aspergillus fumigatus infection   (MGI Ref ID J:74497)
    • delayed presence of T cells in bronchoalveolar lavage fluid with chronic Aspergillus fumigatus infection   (MGI Ref ID J:74497)
  • hematopoietic system phenotype
  • abnormal leukocyte physiology   (MGI Ref ID J:74497)
    • abnormal cytotoxic T cell physiology
      • develop significant levels of cytotoxic lymphocytes specific for 4T1mouse mammary carcinoma cells   (MGI Ref ID J:65894)
    • abnormal immunoglobulin level   (MGI Ref ID J:66222)
      • decreased IgE level
        • no detectable IgE whether OVA challenged or not   (MGI Ref ID J:66222)
        • chronic Aspergillus fumigatus infection fails to elicit serum IgE   (MGI Ref ID J:74497)
      • decreased IgG1 level
        • reduced OVA specific IgG1   (MGI Ref ID J:66222)
      • increased IgG2a level
        • increased OVA specific IgG2a   (MGI Ref ID J:66222)
    • abnormal leukocyte migration
      • only minor peribronchial leukocyte accumulation in response to chronic Aspergillus fumigatus infection   (MGI Ref ID J:74497)
      • delayed presence of T cells in bronchoalveolar lavage fluid with chronic Aspergillus fumigatus infection   (MGI Ref ID J:74497)
    • impaired eosinophil recruitment
      • fewer eosinophils in bronchoalveolar fluid of OVA sensitized mice than in controls although still elevated   (MGI Ref ID J:66222)

Stat6tm1Gru/Stat6tm1Gru

        involves: 129S2/SvPas * C57BL/6
  • homeostasis/metabolism phenotype
  • decreased core body temperature
    • defects in cold induced thermogenesis   (MGI Ref ID J:178294)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cell Biology Research
Signal Transduction
Transcriptional Regulation

Hematological Research
Immunological Defects
      B and T cell deficiency

Immunology, Inflammation and Autoimmunity Research
Autoimmunity
      B and T cell deficiency
      experimental allergic encephalomyelitis (EAE)
Growth Factors/Receptors/Cytokines
Immunodeficiency
      Asthma
      B and T cell deficiency
      MHC class II defects
Inflammation
      Asthma
      B and T cell deficiency

Research Tools
Immunology, Inflammation and Autoimmunity Research
      B and T cell deficiency
      MHC class II defects

Stat6tm1Gru related

Immunology, Inflammation and Autoimmunity Research
Immunodeficiency
Intracellular Signaling Molecules

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Stat6tm1Gru
Allele Name targeted mutation 1, Michael J Grusby
Allele Type Targeted (Null/Knockout)
Common Name(s) S6KO; Stat6-;
Mutation Made ByDr. Michael Grusby,   Harvard Medical School
Strain of Origin129S2/SvPas
ES Cell Line NameD3
ES Cell Line Strain129S2/SvPas
Gene Symbol and Name Stat6, signal transducer and activator of transcription 6
Chromosome 10
Gene Common Name(s) D12S1644; IL-4-STAT; STAT6B; STAT6C;
Molecular Note The region encoding the SH2 domain, which is essential for dimerization, was replaced by the insertion of a neomycin selection cassette. Immunoblot analysis of lysates from the spleens and thymi of homozygous mutant mice showed an absence of encoded protein. [MGI Ref ID J:31932]

Genotyping

Genotyping Information

Genotyping Protocols

Stat6tm1Gru, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Stat6tm1Gru related

Agarwal S; Rao A. 1998. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity 9(6):765-75. [PubMed: 9881967]  [MGI Ref ID J:51833]

Amsen D; Antov A; Jankovic D; Sher A; Radtke F; Souabni A; Busslinger M; McCright B; Gridley T; Flavell RA. 2007. Direct regulation of gata3 expression determines the T helper differentiation potential of notch. Immunity 27(1):89-99. [PubMed: 17658279]  [MGI Ref ID J:123631]

Armstrong BD; Abad C; Chhith S; Cheung-Lau G; Hajji OE; Coute AC; Ngo DH; Waschek JA. 2006. Impairment of axotomy-induced pituitary adenylyl cyclase-activating peptide gene expression in T helper 2 lymphocyte-deficient mice. Neuroreport 17(3):309-12. [PubMed: 16462603]  [MGI Ref ID J:106085]

Beiting DP; Gagliardo LF; Hesse M; Bliss SK; Meskill D; Appleton JA. 2007. Coordinated control of immunity to muscle stage Trichinella spiralis by IL-10, regulatory T cells, and TGF-beta. J Immunol 178(2):1039-47. [PubMed: 17202367]  [MGI Ref ID J:142622]

Bell BD; Kitajima M; Larson RP; Stoklasek TA; Dang K; Sakamoto K; Wagner KU; Reizis B; Hennighausen L; Ziegler SF. 2013. The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses. Nat Immunol 14(4):364-71. [PubMed: 23435120]  [MGI Ref ID J:194747]

Bian K; Zhong M; Harari Y; Lai M; Weisbrodt N; Murad F. 2005. Helminth regulation of host IL-4Ralpha/Stat6 signaling: mechanism underlying NOS-2 inhibition by Trichinella spiralis. Proc Natl Acad Sci U S A 102(11):3936-41. [PubMed: 15741272]  [MGI Ref ID J:97167]

Blease K; Schuh JM; Jakubzick C; Lukacs NW; Kunkel SL; Joshi BH; Puri RK; Kaplan MH; Hogaboam CM. 2002. Stat6-deficient mice develop airway hyperresponsiveness and peribronchial fibrosis during chronic fungal asthma. Am J Pathol 160(2):481-90. [PubMed: 11839568]  [MGI Ref ID J:74497]

Bour-Jordan H; Grogan JL; Tang Q; Auger JA; Locksley RM; Bluestone JA. 2003. CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment. Nat Immunol 4(2):182-8. [PubMed: 12524538]  [MGI Ref ID J:126980]

Broadhurst MJ; Leung JM; Lim KC; Girgis NM; Gundra UM; Fallon PG; Premenko-Lanier M; McKerrow JH; McCune JM; Loke P. 2012. Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice. PLoS Pathog 8(8):e1002883. [PubMed: 22927819]  [MGI Ref ID J:195366]

Broxmeyer HE; Bruns HA; Zhang S; Cooper S; Hangoc G; McKenzie AN; Dent AL; Schindler U; Naeger LK; Hoey T; Kaplan MH. 2002. Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin m. Immunity 16(6):815-25. [PubMed: 12121663]  [MGI Ref ID J:77523]

Brunn A; Mihelcic M; Carstov M; Hummel L; Geier F; Schmidt A; Saupe L; Utermohlen O; Deckert M. 2014. IL-10, IL-4, and STAT6 promote an M2 milieu required for termination of P0(106-125)-induced murine experimental autoimmune neuritis. Am J Pathol 184(10):2627-40. [PubMed: 25108223]  [MGI Ref ID J:214835]

Bunting KD; Yu WM; Bradley HL; Haviernikova E; Kelly-Welch AE; Keegan AD; Qu CK. 2004. Increased numbers of committed myeloid progenitors but not primitive hematopoietic stem/progenitors in mice lacking STAT6 expression. J Leukoc Biol 76(2):484-90. [PubMed: 15123777]  [MGI Ref ID J:91477]

Burgis S; Gessner A. 2007. Unexpected phenotype of STAT6 heterozygous mice implies distinct STAT6 dosage requirements for different IL-4 functions. Int Arch Allergy Immunol 143(4):263-8. [PubMed: 17347574]  [MGI Ref ID J:140305]

Caldwell CC; Chen Y; Goetzmann HS; Hao Y; Borchers MT; Hassett DJ; Young LR; Mavrodi D; Thomashow L; Lau GW. 2009. Pseudomonas aeruginosa exotoxin pyocyanin causes cystic fibrosis airway pathogenesis. Am J Pathol 175(6):2473-88. [PubMed: 19893030]  [MGI Ref ID J:155327]

Castilow EM; Legge KL; Varga SM. 2008. Cutting edge: Eosinophils do not contribute to respiratory syncytial virus vaccine-enhanced disease. J Immunol 181(10):6692-6. [PubMed: 18981084]  [MGI Ref ID J:140954]

Chang HC; Zhang S; Kaplan MH. 2002. Neonatal tolerance in the absence of Stat4- and Stat6- dependent Th cell differentiation. J Immunol 169(8):4124-8. [PubMed: 12370340]  [MGI Ref ID J:120160]

Chang HH; Miaw SC; Tseng W; Sun YW; Liu CC; Tsao HW; Ho IC. 2013. PTPN22 modulates macrophage polarization and susceptibility to dextran sulfate sodium-induced colitis. J Immunol 191(5):2134-43. [PubMed: 23913970]  [MGI Ref ID J:205805]

Chang S; Aune TM. 2007. Dynamic changes in histone-methylation 'marks' across the locus encoding interferon-gamma during the differentiation of T helper type 2 cells. Nat Immunol 8(7):723-31. [PubMed: 17546034]  [MGI Ref ID J:123355]

Chapoval SP; Al-Garawi A; Lora JM; Strickland I; Ma B; Lee PJ; Homer RJ; Ghosh S; Coyle AJ; Elias JA. 2007. Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13. J Immunol 179(10):7030-41. [PubMed: 17982094]  [MGI Ref ID J:154009]

Chapoval SP; Dasgupta P; Smith EP; DeTolla LJ; Lipsky MM; Kelly-Welch AE; Keegan AD. 2011. STAT6 expression in multiple cell types mediates the cooperative development of allergic airway disease. J Immunol 186(4):2571-83. [PubMed: 21242523]  [MGI Ref ID J:169153]

Chen CC; Louie S; McCormick B; Walker WA; Shi HN. 2005. Concurrent infection with an intestinal helminth parasite impairs host resistance to enteric Citrobacter rodentium and enhances Citrobacter-induced colitis in mice. Infect Immun 73(9):5468-81. [PubMed: 16113263]  [MGI Ref ID J:100416]

Chen H; Sun H; You F; Sun W; Zhou X; Chen L; Yang J; Wang Y; Tang H; Guan Y; Xia W; Gu J; Ishikawa H; Gutman D; Barber G; Qin Z; Jiang Z. 2011. Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity. Cell 147(2):436-46. [PubMed: 22000020]  [MGI Ref ID J:177502]

Chen Z; Lund R; Aittokallio T; Kosonen M; Nevalainen O; Lahesmaa R. 2003. Identification of novel IL-4/Stat6-regulated genes in T lymphocytes. J Immunol 171(7):3627-35. [PubMed: 14500660]  [MGI Ref ID J:107367]

Cheng LE; Wang ZE; Locksley RM. 2010. Murine B cells regulate serum IgE levels in a CD23-dependent manner. J Immunol 185(9):5040-7. [PubMed: 20870945]  [MGI Ref ID J:165198]

Chesler DA; Reiss CS. 2002. IL-12, while beneficial, is not essential for the host response to VSV encephalitis. J Neuroimmunol 131(1-2):92-7. [PubMed: 12458040]  [MGI Ref ID J:102956]

Chitnis T; Najafian N; Benou C; Salama AD; Grusby MJ; Sayegh MH; Khoury SJ. 2001. Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. J Clin Invest 108(5):739-47. [PubMed: 11544280]  [MGI Ref ID J:71460]

Chitnis T; Salama AD; Grusby MJ; Sayegh MH; Khoury SJ. 2004. Defining Th1 and Th2 immune responses in a reciprocal cytokine environment in vivo. J Immunol 172(7):4260-5. [PubMed: 15034039]  [MGI Ref ID J:88725]

Chung DR; Kasper DL; Panzo RJ; Chtinis T; Grusby MJ; Sayegh MH; Tzianabos AO. 2003. CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism. J Immunol 170(4):1958-63. [PubMed: 12574364]  [MGI Ref ID J:81809]

Cooney LA; Towery K; Endres J; Fox DA. 2011. Sensitivity and resistance to regulation by IL-4 during Th17 maturation. J Immunol 187(9):4440-50. [PubMed: 21949021]  [MGI Ref ID J:179441]

Cruz-Guilloty F; Saeed AM; Duffort S; Cano M; Ebrahimi KB; Ballmick A; Tan Y; Wang H; Laird JM; Salomon RG; Handa JT; Perez VL. 2014. T cells and macrophages responding to oxidative damage cooperate in pathogenesis of a mouse model of age-related macular degeneration. PLoS One 9(2):e88201. [PubMed: 24586307]  [MGI Ref ID J:213342]

Cunnusamy K; Chen PW; Niederkorn JY. 2010. IL-17 promotes immune privilege of corneal allografts. J Immunol 185(8):4651-8. [PubMed: 20844197]  [MGI Ref ID J:164882]

Dardalhon V; Awasthi A; Kwon H; Galileos G; Gao W; Sobel RA; Mitsdoerffer M; Strom TB; Elyaman W; Ho IC; Khoury S; Oukka M; Kuchroo VK. 2008. IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol 9(12):1347-55. [PubMed: 18997793]  [MGI Ref ID J:143168]

Das J; Ren G; Zhang L; Roberts AI; Zhao X; Bothwell AL; Van Kaer L; Shi Y; Das G. 2009. Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation. J Exp Med 206(11):2407-16. [PubMed: 19808254]  [MGI Ref ID J:154176]

Devoss JJ; Shum AK; Johannes KP; Lu W; Krawisz AK; Wang P; Yang T; Leclair NP; Austin C; Strauss EC; Anderson MS. 2008. Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1. J Immunol 181(6):4072-9. [PubMed: 18768863]  [MGI Ref ID J:139094]

Dickgreber N; Farrand KJ; van Panhuys N; Knight DA; McKee SJ; Chong ML; Miranda-Hernandez S; Baxter AG; Locksley RM; Le Gros G; Hermans IF. 2012. Immature murine NKT cells pass through a stage of developmentally programmed innate IL-4 secretion. J Leukoc Biol 92(5):999-1009. [PubMed: 22941735]  [MGI Ref ID J:190015]

Doherty TA; Khorram N; Sugimoto K; Sheppard D; Rosenthal P; Cho JY; Pham A; Miller M; Croft M; Broide DH. 2012. Alternaria Induces STAT6-Dependent Acute Airway Eosinophilia and Epithelial FIZZ1 Expression That Promotes Airway Fibrosis and Epithelial Thickness. J Immunol 188(6):2622-9. [PubMed: 22327070]  [MGI Ref ID J:181849]

Dorsey NJ; Chapoval SP; Smith EP; Skupsky J; Scott DW; Keegan AD. 2013. STAT6 controls the number of regulatory T cells in vivo, thereby regulating allergic lung inflammation. J Immunol 191(4):1517-28. [PubMed: 23825312]  [MGI Ref ID J:205707]

Eddahri F; Denanglaire S; Bureau F; Spolski R; Leonard WJ; Leo O; Andris F. 2009. Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities. Blood 113(11):2426-33. [PubMed: 19020307]  [MGI Ref ID J:146334]

Fang TC; Yashiro-Ohtani Y; Del Bianco C; Knoblock DM; Blacklow SC; Pear WS. 2007. Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity 27(1):100-10. [PubMed: 17658278]  [MGI Ref ID J:123632]

Fichtner-Feigl S; Kesselring R; Martin M; Obermeier F; Ruemmele P; Kitani A; Brunner SM; Haimerl M; Geissler EK; Strober W; Schlitt HJ. 2014. IL-13 orchestrates resolution of chronic intestinal inflammation via phosphorylation of glycogen synthase kinase-3beta. J Immunol 192(8):3969-80. [PubMed: 24634488]  [MGI Ref ID J:210014]

Finkelman FD; Morris SC; Orekhova T; Mori M; Donaldson D; Reiner SL; Reilly NL; Schopf L; Urban JF Jr. 2000. Stat6 regulation of in vivo IL-4 responses. J Immunol 164(5):2303-10. [PubMed: 10679064]  [MGI Ref ID J:112038]

Finnegan A; Grusby MJ; Kaplan CD; O'Neill SK; Eibel H; Koreny T; Czipri M; Mikecz K; Zhang J. 2002. IL-4 and IL-12 regulate proteoglycan-induced arthritis through Stat-dependent mechanisms. J Immunol 169(6):3345-52. [PubMed: 12218156]  [MGI Ref ID J:120443]

Fraidakis MJ; Kiyotani T; Pernold K; Bergstrom J; Olson L. 2007. Recovery from spinal cord injury in tumor necrosis factor-alpha, signal transducers and activators of transcription 4 and signal transducers and activators of transcription 6 null mice. Neuroreport 18(2):185-9. [PubMed: 17301687]  [MGI Ref ID J:120345]

Gallo E; Katzman S; Villarino AV. 2012. IL-13-producing Th1 and Th17 cells characterize adaptive responses to both self and foreign antigens. Eur J Immunol 42(9):2322-8. [PubMed: 22684943]  [MGI Ref ID J:187947]

Ghiasi H; Osorio Y; Nesburn AB; Wechsler SL. 2002. Enhanced clearance of herpes simplex virus type 1 and reduced herpetic eye disease in STAT6 knockout mice is associated with increased IL-2. Virology 302(2):286-93. [PubMed: 12441072]  [MGI Ref ID J:107370]

Goswami R; Jabeen R; Yagi R; Pham D; Zhu J; Goenka S; Kaplan MH. 2012. STAT6-dependent regulation of Th9 development. J Immunol 188(3):968-75. [PubMed: 22180613]  [MGI Ref ID J:180779]

Goswami S; Angkasekwinai P; Shan M; Greenlee KJ; Barranco WT; Polikepahad S; Seryshev A; Song LZ; Redding D; Singh B; Sur S; Woodruff P; Dong C; Corry DB; Kheradmand F. 2009. Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma. Nat Immunol 10(5):496-503. [PubMed: 19329997]  [MGI Ref ID J:148285]

Gundra UM; Girgis NM; Ruckerl D; Jenkins S; Ward LN; Kurtz ZD; Wiens KE; Tang MS; Basu-Roy U; Mansukhani A; Allen JE; Loke P. 2014. Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct. Blood 123(20):e110-22. [PubMed: 24695852]  [MGI Ref ID J:212404]

Guo B; Rothstein TL. 2013. IL-4 upregulates Igalpha and Igbeta protein, resulting in augmented IgM maturation and B cell receptor-triggered B cell activation. J Immunol 191(2):670-7. [PubMed: 23776171]  [MGI Ref ID J:205452]

Guseh JS; Bores SA; Stanger BZ; Zhou Q; Anderson WJ; Melton DA; Rajagopal J. 2009. Notch signaling promotes airway mucous metaplasia and inhibits alveolar development. Development 136(10):1751-9. [PubMed: 19369400]  [MGI Ref ID J:148016]

Haapakoski R; Karisola P; Fyhrquist N; Savinko T; Wolff H; Turjanmaa K; Palosuo T; Reunala T; Lauerma A; Alenius H. 2011. Intradermal cytosine-phosphate-guanosine treatment reduces lung inflammation but induces IFN-gamma-mediated airway hyperreactivity in a murine model of natural rubber latex allergy. Am J Respir Cell Mol Biol 44(5):639-47. [PubMed: 20581096]  [MGI Ref ID J:183350]

Haczku A; Cao Y; Vass G; Kierstein S; Nath P; Atochina-Vasserman EN; Scanlon ST; Li L; Griswold DE; Chung KF; Poulain FR; Hawgood S; Beers MF; Crouch EC. 2006. IL-4 and IL-13 form a negative feedback circuit with surfactant protein-D in the allergic airway response. J Immunol 176(6):3557-65. [PubMed: 16517724]  [MGI Ref ID J:129507]

Hadeiba H; Locksley RM. 2003. Lung CD25 CD4 regulatory T cells suppress type 2 immune responses but not bronchial hyperreactivity. J Immunol 170(11):5502-10. [PubMed: 12759427]  [MGI Ref ID J:109990]

Hakim O; Sung MH; Nakayamada S; Voss TC; Baek S; Hager GL. 2013. Spatial congregation of STAT binding directs selective nuclear architecture during T-cell functional differentiation. Genome Res 23(3):462-72. [PubMed: 23212947]  [MGI Ref ID J:198013]

Han H; Headley MB; Xu W; Comeau MR; Zhou B; Ziegler SF. 2013. Thymic stromal lymphopoietin amplifies the differentiation of alternatively activated macrophages. J Immunol 190(3):904-12. [PubMed: 23275605]  [MGI Ref ID J:193032]

Han NR; Oh HA; Nam SY; Moon PD; Kim DW; Kim HM; Jeong HJ. 2014. TSLP induces mast cell development and aggravates allergic reactions through the activation of MDM2 and STAT6. J Invest Dermatol 134(10):2521-30. [PubMed: 24751726]  [MGI Ref ID J:214773]

Harrington LE; Hatton RD; Mangan PR; Turner H; Murphy TL; Murphy KM; Weaver CT. 2005. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6(11):1123-32. [PubMed: 16200070]  [MGI Ref ID J:112601]

Harris MB; Chang CC; Berton MT; Danial NN; Zhang J; Kuehner D; Ye BH; Kvatyuk M; Pandolfi PP; Cattoretti G; Dalla-Favera R; Rothman PB. 1999. Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching. Mol Cell Biol 19(10):7264-75. [PubMed: 10490661]  [MGI Ref ID J:57856]

Herold KC; Lu J; Rulifson I; Vezys V; Taub D; Grusby MJ; Bluestone JA. 1997. Regulation of C-C chemokine production by murine T cells by CD28/B7 costimulation. J Immunol 159(9):4150-3. [PubMed: 9379007]  [MGI Ref ID J:110673]

Holz A; Bot A; Coon B; Wolfe T; Grusby MJ; von Herrath MG. 1999. Disruption of the STAT4 signaling pathway protects from autoimmune diabetes while retaining antiviral immune competence. J Immunol 163(10):5374-82. [PubMed: 10553062]  [MGI Ref ID J:107047]

Hoshino A; Tsuji T; Matsuzaki J; Jinushi T; Ashino S; Teramura T; Chamoto K; Tanaka Y; Asakura Y; Sakurai T; Mita Y; Takaoka A; Nakaike S; Takeshima T; Ikeda H; Nishimura T. 2004. STAT6-mediated signaling in Th2-dependent allergic asthma: critical role for the development of eosinophilia, airway hyper-responsiveness and mucus hypersecretion, distinct from its role in Th2 differentiation. Int Immunol 16(10):1497-505. [PubMed: 15351784]  [MGI Ref ID J:93632]

Howell MD; Gallo RL; Boguniewicz M; Jones JF; Wong C; Streib JE; Leung DY. 2006. Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus. Immunity 24(3):341-8. [PubMed: 16546102]  [MGI Ref ID J:113325]

Huang P; Huo Y; Lou LX; Li H; Barnstable CJ; Zhang C; Zhang SS. 2013. CD4 positive T helper cells contribute to retinal ganglion cell death in mouse model of ischemia reperfusion injury. Exp Eye Res 115:131-9. [PubMed: 23792169]  [MGI Ref ID J:210412]

Huang W; Huang F; Kannan AK; Hu J; August A. 2014. ITK tunes IL-4-induced development of innate memory CD8+ T cells in a gammadelta T and invariant NKT cell-independent manner. J Leukoc Biol 96(1):55-63. [PubMed: 24620029]  [MGI Ref ID J:212002]

Huber S; Hoffmann R; Muskens F; Voehringer D. 2010. Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2. Blood 116(17):3311-20. [PubMed: 20625006]  [MGI Ref ID J:165869]

Huber SA; Sakkinen P; David C; Newell MK; Tracy RP. 2001. T helper-cell phenotype regulates atherosclerosis in mice under conditions of mild hypercholesterolemia. Circulation 103(21):2610-6. [PubMed: 11382732]  [MGI Ref ID J:133189]

Ingram JL; Antao-Menezes A; Mangum JB; Lyght O; Lee PJ; Elias JA; Bonner JC. 2006. Opposing actions of Stat1 and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor ligands in pulmonary fibroblasts. J Immunol 177(6):4141-8. [PubMed: 16951379]  [MGI Ref ID J:138041]

Iribarren P; Chen K; Hu J; Zhang X; Gong W; Wang JM. 2005. IL-4 inhibits the expression of mouse formyl peptide receptor 2, a receptor for amyloid beta1-42, in TNF-alpha-activated microglia. J Immunol 175(9):6100-6. [PubMed: 16237106]  [MGI Ref ID J:119383]

Ishii M; Wen H; Corsa CA; Liu T; Coelho AL; Allen RM; Carson WF 4th; Cavassani KA; Li X; Lukacs NW; Hogaboam CM; Dou Y; Kunkel SL. 2009. Epigenetic regulation of the alternatively activated macrophage phenotype. Blood 114(15):3244-54. [PubMed: 19567879]  [MGI Ref ID J:153569]

Ishikawa Y; Yoshimoto T; Nakanishi K. 2006. Contribution of IL-18-induced innate T cell activation to airway inflammation with mucus hypersecretion and airway hyperresponsiveness. Int Immunol 18(6):847-55. [PubMed: 16611648]  [MGI Ref ID J:109098]

Jabeen R; Goswami R; Awe O; Kulkarni A; Nguyen ET; Attenasio A; Walsh D; Olson MR; Kim MH; Tepper RS; Sun J; Kim CH; Taparowsky EJ; Zhou B; Kaplan MH. 2013. Th9 cell development requires a BATF-regulated transcriptional network. J Clin Invest :. [PubMed: 24216482]  [MGI Ref ID J:204178]

Jacob CO; Zang S; Li L; Ciobanu V; Quismorio F; Mizutani A; Satoh M; Koss M. 2003. Pivotal role of Stat4 and Stat6 in the pathogenesis of the lupus-like disease in the New Zealand mixed 2328 mice. J Immunol 171(3):1564-71. [PubMed: 12874250]  [MGI Ref ID J:120665]

Jaruga B; Hong F; Sun R; Radaeva S; Gao B. 2003. Crucial role of IL-4/STAT6 in T cell-mediated hepatitis: up-regulating eotaxins and IL-5 and recruiting leukocytes. J Immunol 171(6):3233-44. [PubMed: 12960353]  [MGI Ref ID J:85386]

Jensen KD; Hu K; Whitmarsh RJ; Hassan MA; Julien L; Lu D; Chen L; Hunter CA; Saeij JP. 2013. Toxoplasma gondii rhoptry 16 kinase promotes host resistance to oral infection and intestinal inflammation only in the context of the dense granule protein GRA15. Infect Immun 81(6):2156-67. [PubMed: 23545295]  [MGI Ref ID J:199524]

Jensen SM; Meijer SL; Kurt RA; Urba WJ; Hu HM; Fox BA. 2003. Regression of a mammary adenocarcinoma in STAT6-/- mice is dependent on the presence of STAT6-reactive T cells. J Immunol 170(4):2014-21. [PubMed: 12574371]  [MGI Ref ID J:107369]

Jessup HK; Brewer AW; Omori M; Rickel EA; Budelsky AL; Yoon BR; Ziegler SF; Comeau MR. 2008. Intradermal administration of thymic stromal lymphopoietin induces a T cell- and eosinophil-dependent systemic Th2 inflammatory response. J Immunol 181(6):4311-9. [PubMed: 18768889]  [MGI Ref ID J:139079]

Jones TG; Hallgren J; Humbles A; Burwell T; Finkelman FD; Alcaide P; Austen KF; Gurish MF. 2009. Antigen-induced increases in pulmonary mast cell progenitor numbers depend on IL-9 and CD1d-restricted NKT cells. J Immunol 183(8):5251-60. [PubMed: 19783672]  [MGI Ref ID J:153832]

Junttila IS; Mizukami K; Dickensheets H; Meier-Schellersheim M; Yamane H; Donnelly RP; Paul WE. 2008. Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity. J Exp Med 205(11):2595-608. [PubMed: 18852293]  [MGI Ref ID J:141103]

Kacha AK; Fallarino F; Markiewicz MA; Gajewski TF. 2000. Spontaneous rejection of poorly immunogenic P1.HTR tumors by Stat6-deficient mice J Immunol 165(11):6024-8. [PubMed: 11086033]  [MGI Ref ID J:65893]

Kaplan MH; Schindler U; Smiley ST; Grusby MJ. 1996. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 4(3):313-9. [PubMed: 8624821]  [MGI Ref ID J:31932]

Kaplan MH; Wurster AL; Grusby MJ. 1998. A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells. J Exp Med 188(6):1191-6. [PubMed: 9743537]  [MGI Ref ID J:50032]

Kaplan MH; Wurster AL; Smiley ST; Grusby MJ. 1999. Stat6-dependent and -independent pathways for IL-4 production. J Immunol 163(12):6536-40. [PubMed: 10586046]  [MGI Ref ID J:112135]

Kashyap M; Rochman Y; Spolski R; Samsel L; Leonard WJ. 2011. Thymic stromal lymphopoietin is produced by dendritic cells. J Immunol 187(3):1207-11. [PubMed: 21690322]  [MGI Ref ID J:179117]

Kato A; Yoshidome H; Edwards MJ; Lentsch AB. 2000. Regulation of liver inflammatory injury by signal transducer and activator of transcription-6. Am J Pathol 157(1):297-302. [PubMed: 10880399]  [MGI Ref ID J:63136]

Ketavarapu JM; Rodriguez AR; Yu JJ; Cong Y; Murthy AK; Forsthuber TG; Guentzel MN; Klose KE; Berton MT; Arulanandam BP. 2008. Mast cells inhibit intramacrophage Francisella tularensis replication via contact and secreted products including IL-4. Proc Natl Acad Sci U S A 105(27):9313-8. [PubMed: 18591675]  [MGI Ref ID J:138191]

Khaled WT; Read EK; Nicholson SE; Baxter FO; Brennan AJ; Came PJ; Sprigg N; McKenzie AN; Watson CJ. 2007. The IL-4/IL-13/Stat6 signalling pathway promotes luminal mammary epithelial cell development. Development 134(15):2739-50. [PubMed: 17611223]  [MGI Ref ID J:124116]

Khan MM; Chatterjee S; Dwivedi VP; Pandey NK; Singh Y; Tousif S; Bhavesh NS; Van Kaer L; Das J; Das G. 2012. CD4+ T cell-derived novel peptide Thp5 induces interleukin-4 production in CD4+ T cells to direct T helper 2 cell differentiation. J Biol Chem 287(4):2830-5. [PubMed: 22130674]  [MGI Ref ID J:209711]

Khan R; Lee JE; Yang YM; Liang FX; Sehgal PB. 2013. Live-cell imaging of the association of STAT6-GFP with mitochondria. PLoS One 8(1):e55426. [PubMed: 23383189]  [MGI Ref ID J:195782]

Khodoun M; Lewis CC; Yang JQ; Orekov T; Potter C; Wynn T; Mentink-Kane M; Hershey GK; Wills-Karp M; Finkelman FD. 2007. Differences in expression, affinity, and function of soluble (s)IL-4Ralpha and sIL-13Ralpha2 suggest opposite effects on allergic responses. J Immunol 179(10):6429-38. [PubMed: 17982031]  [MGI Ref ID J:153871]

King SB; Knorn AM; Ohnmacht C; Voehringer D. 2008. Accumulation of effector CD4 T cells during type 2 immune responses is negatively regulated by Stat6. J Immunol 180(2):754-63. [PubMed: 18178813]  [MGI Ref ID J:130967]

Kishimoto K; Dong VM; Issazadeh S; Fedoseyeva EV; Waaga AM; Yamada A; Sho M; Benichou G; Auchincloss H Jr; Grusby MJ; Khoury SJ; Sayegh MH. 2000. The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo. J Clin Invest 106(1):63-72. [PubMed: 10880049]  [MGI Ref ID J:63156]

Kitajima M; Lee HC; Nakayama T; Ziegler SF. 2011. TSLP enhances the function of helper type 2 cells. Eur J Immunol 41(7):1862-71. [PubMed: 21484783]  [MGI Ref ID J:177311]

Knott ML; Matthaei KI; Foster PS; Dent LA. 2009. The roles of eotaxin and the STAT6 signalling pathway in eosinophil recruitment and host resistance to the nematodes Nippostrongylus brasiliensis and Heligmosomoides bakeri. Mol Immunol 46(13):2714-22. [PubMed: 19535141]  [MGI Ref ID J:151720]

Kriebel P; Patel BK; Nelson SA; Grusby MJ; LaRochelle WJ. 1999. Consequences of Stat6 deletion on Sis/PDGF- and IL-4-induced proliferation and transcriptional activation in murine fibroblasts. Oncogene 18(51):7294-302. [PubMed: 10602484]  [MGI Ref ID J:59015]

Kuperman D; Schofield B; Wills-Karp M; Grusby MJ. 1998. Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production. J Exp Med 187(6):939-48. [PubMed: 9500796]  [MGI Ref ID J:66222]

Kuperman DA; Huang X; Koth LL; Chang GH; Dolganov GM; Zhu Z; Elias JA; Sheppard D; Erle DJ. 2002. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med 8(8):885-9. [PubMed: 12091879]  [MGI Ref ID J:132385]

Kurowska-Stolarska M; Kewin P; Murphy G; Russo RC; Stolarski B; Garcia CC; Komai-Koma M; Pitman N; Li Y; McKenzie AN; Teixeira MM; Liew FY; Xu D. 2008. IL-33 induces antigen-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4. J Immunol 181(7):4780-90. [PubMed: 18802081]  [MGI Ref ID J:141876]

Kusmartsev S; Gabrilovich DI. 2005. STAT1 signaling regulates tumor-associated macrophage-mediated T cell deletion. J Immunol 174(8):4880-91. [PubMed: 15814715]  [MGI Ref ID J:109996]

Land KJ; Gudapati P; Kaplan MH; Seetharamaiah GS. 2006. Differential requirement of signal transducer and activator of transcription-4 (Stat4) and Stat6 in a thyrotropin receptor-289-adenovirus-induced model of Graves' hyperthyroidism. Endocrinology 147(1):111-9. [PubMed: 16195404]  [MGI Ref ID J:129448]

Le Saux CJ; Teeters K; Miyasato SK; Hoffmann PR; Bollt O; Douet V; Shohet RV; Broide DH; Tam EK. 2008. Down-regulation of caveolin-1, an inhibitor of transforming growth factor-beta signaling, in acute allergen-induced airway remodeling. J Biol Chem 283(9):5760-8. [PubMed: 18056268]  [MGI Ref ID J:132297]

Lee CG; Homer RJ; Cohn L; Link H; Jung S; Craft JE; Graham BS; Johnson TR; Elias JA. 2002. Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways. J Biol Chem 277(38):35466-74. [PubMed: 12107190]  [MGI Ref ID J:79116]

Lee PJ; Zhang X; Shan P; Ma B; Lee CG; Homer RJ; Zhu Z; Rincon M; Mossman BT; Elias JA. 2006. ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo. J Clin Invest 116(1):163-73. [PubMed: 16374521]  [MGI Ref ID J:105338]

Lei L; Zhang Y; Yao W; Kaplan MH; Zhou B. 2011. Thymic stromal lymphopoietin interferes with airway tolerance by suppressing the generation of antigen-specific regulatory T cells. J Immunol 186(4):2254-61. [PubMed: 21242516]  [MGI Ref ID J:169154]

Levings MK; Schrader JW. 1999. IL-4 inhibits the production of TNF-alpha and IL-12 by STAT6-dependent and -independent mechanisms. J Immunol 162(9):5224-9. [PubMed: 10227996]  [MGI Ref ID J:112259]

Li J. 2013. JAK-STAT and bone metabolism. JAKSTAT 2(3):e23930. [PubMed: 24069548]  [MGI Ref ID J:202463]

Li J; Bessho K; Shivakumar P; Mourya R; Mohanty SK; Dos Santos JL; Miura IK; Porta G; Bezerra JA. 2011. Th2 signals induce epithelial injury in mice and are compatible with the biliary atresia phenotype. J Clin Invest 121(11):4244-56. [PubMed: 22005305]  [MGI Ref ID J:178721]

Li W; Ferguson BJ; Khaled WT; Tevendale M; Stingl J; Poli V; Rich T; Salomoni P; Watson CJ. 2009. PML depletion disrupts normal mammary gland development and skews the composition of the mammary luminal cell progenitor pool. Proc Natl Acad Sci U S A 106(12):4725-30. [PubMed: 19261859]  [MGI Ref ID J:147092]

Li W; Sofi MH; Yeh N; Sehra S; McCarthy BP; Patel DR; Brutkiewicz RR; Kaplan MH; Chang CH. 2007. Thymic selection pathway regulates the effector function of CD4 T cells. J Exp Med 204(9):2145-57. [PubMed: 17724129]  [MGI Ref ID J:126084]

Li Z; Zhang Y; Liu Z; Wu X; Zheng Y; Tao Z; Mao K; Wang J; Lin G; Tian L; Ji Y; Qin M; Sun S; Zhu X; Sun B. 2011. ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1). Nat Immunol 12(2):178-85. [PubMed: 21217760]  [MGI Ref ID J:168252]

Lin W; Truong N; Grossman WJ; Haribhai D; Williams CB; Wang J; Martin MG; Chatila TA. 2005. Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. J Allergy Clin Immunol 116(5):1106-15. [PubMed: 16275384]  [MGI Ref ID J:117165]

Linehan LA; Warren WD; Thompson PA; Grusby MJ; Berton MT. 1998. STAT6 is required for IL-4-induced germline Ig gene transcription and switch recombination. J Immunol 161(1):302-10. [PubMed: 9647237]  [MGI Ref ID J:110888]

Liu Q; Arseculeratne C; Liu Z; Whitmire J; Grusby MJ; Finkelman FD; Darling TN; Cheever AW; Swearengen J; Urban JF; Gause WC. 2004. Simultaneous deficiency in CD28 and STAT6 results in chronic ectoparasite-induced inflammatory skin disease. Infect Immun 72(7):3706-15. [PubMed: 15213110]  [MGI Ref ID J:90987]

Liu T; Baek HA; Yu H; Lee HJ; Park BH; Ullenbruch M; Liu J; Nakashima T; Choi YY; Wu GD; Chung MJ; Phan SH. 2011. FIZZ2/RELM-beta induction and role in pulmonary fibrosis. J Immunol 187(1):450-61. [PubMed: 21602491]  [MGI Ref ID J:175949]

Liu Z; Li Z; Mao K; Zou J; Wang Y; Tao Z; Lin G; Tian L; Ji Y; Wu X; Zhu X; Sun S; Chen W; Xiang C; Sun B. 2009. Dec2 promotes Th2 cell differentiation by enhancing IL-2R signaling. J Immunol 183(10):6320-9. [PubMed: 19880450]  [MGI Ref ID J:157167]

Lu TX; Munitz A; Rothenberg ME. 2009. MicroRNA-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression. J Immunol 182(8):4994-5002. [PubMed: 19342679]  [MGI Ref ID J:147494]

Macey MR; Sturgill JL; Morales JK; Falanga YT; Morales J; Norton SK; Yerram N; Shim H; Fernando J; Gifillan AM; Gomez G; Schwartz L; Oskeritzian C; Spiegel S; Conrad D; Ryan JJ. 2010. IL-4 and TGF-beta1 counterbalance one another while regulating mast cell homeostasis. J Immunol 184(9):4688-95. [PubMed: 20304823]  [MGI Ref ID J:160220]

Madden KB; Whitman L; Sullivan C; Gause WC; Urban JF Jr; Katona IM; Finkelman FD; Shea-Donohue T. 2002. Role of STAT6 and mast cells in IL-4- and IL-13-induced alterations in murine intestinal epithelial cell function. J Immunol 169(8):4417-22. [PubMed: 12370375]  [MGI Ref ID J:120045]

Madden KB; Yeung KA; Zhao A; Gause WC; Finkelman FD; Katona IM; Urban JF Jr; Shea-Donohue T. 2004. Enteric nematodes induce stereotypic STAT6-dependent alterations in intestinal epithelial cell function. J Immunol 172(9):5616-21. [PubMed: 15100305]  [MGI Ref ID J:89646]

Maerten P; Shen C; Bullens DM; Van Assche G; Van Gool S; Geboes K; Rutgeerts P; Ceuppens JL. 2005. Effects of interleukin 4 on CD25+CD4+ regulatory T cell function. J Autoimmun 25(2):112-20. [PubMed: 16051465]  [MGI Ref ID J:102760]

Mari N; Hercor M; Denanglaire S; Leo O; Andris F. 2013. The capacity of Th2 lymphocytes to deliver B-cell help requires expression of the transcription factor STAT3. Eur J Immunol 43(6):1489-98. [PubMed: 23504518]  [MGI Ref ID J:198123]

Martin RA; Ather JL; Daggett R; Hoyt L; Alcorn JF; Suratt BT; Weiss DJ; Lundblad LK; Poynter ME. 2013. The endogenous Th17 response in NO2-promoted allergic airway disease is dispensable for airway hyperresponsiveness and distinct from Th17 adoptive transfer. PLoS One 8(9):e74730. [PubMed: 24069338]  [MGI Ref ID J:207534]

Mathew A; MacLean JA; DeHaan E; Tager AM; Green FH; Luster AD. 2001. Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in allergic pulmonary inflammation. J Exp Med 193(9):1087-96. [PubMed: 11342593]  [MGI Ref ID J:120521]

Matsukawa A; Kaplan MH; Hogaboam CM; Lukacs NW; Kunkel SL. 2001. Pivotal role of signal transducer and activator of transcription (stat)4 and stat6 in the innate immune response during sepsis. J Exp Med 193(6):679-88. [PubMed: 11257135]  [MGI Ref ID J:68143]

Mikhak Z; Fleming CM; Medoff BD; Thomas SY; Tager AM; Campanella GS; Luster AD. 2006. STAT1 in peripheral tissue differentially regulates homing of antigen-specific Th1 and Th2 cells. J Immunol 176(8):4959-67. [PubMed: 16585592]  [MGI Ref ID J:131153]

Mishra A; Wang M; Schlotman J; Nikolaidis NM; DeBrosse CW; Karow ML; Rothenberg ME. 2007. Resistin-like molecule-beta is an allergen-induced cytokine with inflammatory and remodeling activity in the murine lung. Am J Physiol Lung Cell Mol Physiol 293(2):L305-13. [PubMed: 17545488]  [MGI Ref ID J:125839]

Miyamoto H; Katsuyama E; Miyauchi Y; Hoshi H; Miyamoto K; Sato Y; Kobayashi T; Iwasaki R; Yoshida S; Mori T; Kanagawa H; Fujie A; Hao W; Morioka H; Matsumoto M; Toyama Y; Miyamoto T. 2012. An essential role for STAT6-STAT1 protein signaling in promoting macrophage cell-cell fusion. J Biol Chem 287(39):32479-84. [PubMed: 22865856]  [MGI Ref ID J:191592]

Moreno JL; Mikhailenko I; Tondravi MM; Keegan AD. 2007. IL-4 promotes the formation of multinucleated giant cells from macrophage precursors by a STAT6-dependent, homotypic mechanism: contribution of E-cadherin. J Leukoc Biol 82(6):1542-53. [PubMed: 17855502]  [MGI Ref ID J:129938]

Morimoto M; Morimoto M; Zhao A; Madden KB; Dawson H; Finkelman FD; Mentink-Kane M; Urban JF Jr; Wynn TA; Shea-Donohue T. 2006. Functional importance of regional differences in localized gene expression of receptors for IL-13 in murine gut. J Immunol 176(1):491-5. [PubMed: 16365442]  [MGI Ref ID J:126259]

Morimoto Y; Bian Y; Gao P; Yashiro-Ohtani Y; Zhou XY; Ono S; Nakahara H; Kogo M; Hamaoka T; Fujiwara H. 2005. Induction of surface CCR4 and its functionality in mouse Th2 cells is regulated differently during Th2 development. J Leukoc Biol 78(3):753-61. [PubMed: 16126843]  [MGI Ref ID J:100501]

Morris SC; Orekhova T; Meadows MJ; Heidorn SM; Yang J; Finkelman FD. 2006. IL-4 induces in vivo production of IFN-gamma by NK and NKT cells. J Immunol 176(9):5299-305. [PubMed: 16621996]  [MGI Ref ID J:131660]

Morse HC 3rd; McCarty T; Giese NA; Taddesse-Heath L; Grusby MJ. 1999. STAT6-deficient mice exhibit normal induction of murine AIDS and expression of immunoglobulin E following infection with LP-BM5 murine leukemia viruses. J Virol 73(8):7093-5. [PubMed: 10400816]  [MGI Ref ID J:56313]

Munitz A; Bachelet I; Finkelman FD; Rothenberg ME; Levi-Schaffer F. 2007. CD48 is critically involved in allergic eosinophilic airway inflammation. Am J Respir Crit Care Med 175(9):911-8. [PubMed: 17290046]  [MGI Ref ID J:147553]

Munitz A; McBride ML; Bernstein JS; Rothenberg ME. 2008. A dual activation and inhibition role for the paired immunoglobulin-like receptor B in eosinophils. Blood 111(12):5694-703. [PubMed: 18316626]  [MGI Ref ID J:136634]

Myneni SR; Settem RP; Connell TD; Keegan AD; Gaffen SL; Sharma A. 2011. TLR2 signaling and Th2 responses drive Tannerella forsythia-induced periodontal bone loss. J Immunol 187(1):501-9. [PubMed: 21632710]  [MGI Ref ID J:175931]

Nakahira M; Nakanishi K. 2011. Requirement of GATA-binding protein 3 for Il13 gene expression in IL-18-stimulated Th1 cells. Int Immunol 23(12):761-72. [PubMed: 22039015]  [MGI Ref ID J:178685]

Nakayamada S; Kanno Y; Takahashi H; Jankovic D; Lu KT; Johnson TA; Sun HW; Vahedi G; Hakim O; Handon R; Schwartzberg PL; Hager GL; O'Shea JJ. 2011. Early Th1 Cell Differentiation Is Marked by a Tfh Cell-like Transition. Immunity 35(6):919-31. [PubMed: 22195747]  [MGI Ref ID J:179278]

Nandakumar KS; Holmdahl R. 2006. Arthritis induced with cartilage-specific antibodiesis IL-4-dependent. Eur J Immunol 36(6):1608-18. [PubMed: 16688680]  [MGI Ref ID J:115066]

Nemeth K; Keane-Myers A; Brown JM; Metcalfe DD; Gorham JD; Bundoc VG; Hodges MG; Jelinek I; Madala S; Karpati S; Mezey E. 2010. Bone marrow stromal cells use TGF-beta to suppress allergic responses in a mouse model of ragweed-induced asthma. Proc Natl Acad Sci U S A 107(12):5652-7. [PubMed: 20231466]  [MGI Ref ID J:158920]

Newcomb DC; Boswell MG; Huckabee MM; Goleniewska K; Dulek DE; Reiss S; Lukacs NW; Kolls JK; Peebles RS Jr. 2012. IL-13 regulates Th17 secretion of IL-17A in an IL-10-dependent manner. J Immunol 188(3):1027-35. [PubMed: 22210911]  [MGI Ref ID J:180747]

Newcomb DC; Boswell MG; Sherrill TP; Polosukhin VV; Boyd KL; Goleniewska K; Brody SL; Kolls JK; Adler KB; Peebles RS Jr. 2013. IL-17A induces signal transducers and activators of transcription-6-independent airway mucous cell metaplasia. Am J Respir Cell Mol Biol 48(6):711-6. [PubMed: 23392574]  [MGI Ref ID J:211754]

Nguyen CQ; Gao JH; Kim H; Saban DR; Cornelius JG; Peck AB. 2007. IL-4-STAT6 signal transduction-dependent induction of the clinical phase of Sjogren's syndrome-like disease of the nonobese diabetic mouse. J Immunol 179(1):382-90. [PubMed: 17579059]  [MGI Ref ID J:149416]

Nguyen KD; Qiu Y; Cui X; Goh YP; Mwangi J; David T; Mukundan L; Brombacher F; Locksley RM; Chawla A. 2011. Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature 480(7375):104-8. [PubMed: 22101429]  [MGI Ref ID J:178294]

Nikolic B; Lee S; Bronson RT; Grusby MJ; Sykes M. 2000. Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets. J Clin Invest 105(9):1289-98. [PubMed: 10792004]  [MGI Ref ID J:62114]

Nurieva RI; Chung Y; Hwang D; Yang XO; Kang HS; Ma L; Wang YH; Watowich SS; Jetten AM; Tian Q; Dong C. 2008. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29(1):138-49. [PubMed: 18599325]  [MGI Ref ID J:137869]

Ohnmacht C; Voehringer D. 2010. Basophils protect against reinfection with hookworms independently of mast cells and memory Th2 cells. J Immunol 184(1):344-50. [PubMed: 19955520]  [MGI Ref ID J:158997]

Okabe Y; Medzhitov R. 2014. Tissue-specific signals control reversible program of localization and functional polarization of macrophages. Cell 157(4):832-44. [PubMed: 24792964]  [MGI Ref ID J:214405]

Oliver CH; Khaled WT; Frend H; Nichols J; Watson CJ. 2012. The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3. Genes Dev 26(10):1086-97. [PubMed: 22588720]  [MGI Ref ID J:184505]

Olsan EE; Mukherjee S; Wulkersdorfer B; Shillingford JM; Giovannone AJ; Todorov G; Song X; Pei Y; Weimbs T. 2011. Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney disease. Proc Natl Acad Sci U S A 108(44):18067-72. [PubMed: 22025716]  [MGI Ref ID J:180251]

Ong CJ; Ip S; Teh SJ; Wong C; Jirik FR; Grusby MJ; Teh HS. 1999. A role for T helper 2 cells in mediating skin fibrosis in tight-skin mice. Cell Immunol 196(1):60-8. [PubMed: 10486156]  [MGI Ref ID J:57957]

Ostrand-Rosenberg S; Clements VK; Terabe M; Park JM; Berzofsky JA; Dissanayake SK. 2002. Resistance to metastatic disease in STAT6-deficient mice requires hemopoietic and nonhemopoietic cells and is IFN-gamma dependent. J Immunol 169(10):5796-804. [PubMed: 12421960]  [MGI Ref ID J:80028]

Ostrand-Rosenberg S; Grusby MJ; Clements VK. 2000. Cutting edge: STAT6-deficient mice have enhanced tumor immunity to primary and metastatic mammary carcinoma J Immunol 165(11):6015-9. [PubMed: 11086031]  [MGI Ref ID J:65894]

Ostrand-Rosenberg S; Sinha P; Clements V; Dissanayake SI; Miller S; Davis C; Danna E. 2004. Signal transducer and activator of transcription 6 (Stat6) and CD1: inhibitors of immunosurveillance against primary tumors and metastatic disease. Cancer Immunol Immunother 53(2):86-91. [PubMed: 14593499]  [MGI Ref ID J:86509]

Ouyang W; Ranganath SH; Weindel K; Bhattacharya D; Murphy TL; Sha WC; Murphy KM. 1998. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity 9(5):745-55. [PubMed: 9846495]  [MGI Ref ID J:51355]

Palmqvist P; Lundberg P; Persson E; Johansson A; Lundgren I; Lie A; Conaway HH; Lerner UH. 2006. Inhibition of hormone and cytokine-stimulated osteoclastogenesis and bone resorption by interleukin-4 and interleukin-13 is associated with increased osteoprotegerin and decreased RANKL and RANK in a STAT6-dependent pathway. J Biol Chem 281(5):2414-29. [PubMed: 16251181]  [MGI Ref ID J:107499]

Park H; Li Z; Yang XO; Chang SH; Nurieva R; Wang YH; Wang Y; Hood L; Zhu Z; Tian Q; Dong C. 2005. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 6(11):1133-41. [PubMed: 16200068]  [MGI Ref ID J:112600]

Park JH; Adoro S; Guinter T; Erman B; Alag AS; Catalfamo M; Kimura MY; Cui Y; Lucas PJ; Gress RE; Kubo M; Hennighausen L; Feigenbaum L; Singer A. 2010. Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells. Nat Immunol 11(3):257-64. [PubMed: 20118929]  [MGI Ref ID J:158504]

Park JH; Adoro S; Lucas PJ; Sarafova SD; Alag AS; Doan LL; Erman B; Liu X; Ellmeier W; Bosselut R; Feigenbaum L; Singer A. 2007. 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. Nat Immunol 8(10):1049-59. [PubMed: 17873878]  [MGI Ref ID J:125259]

Park K; Scott AL. 2010. Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons. J Leukoc Biol 88(6):1081-7. [PubMed: 20699362]  [MGI Ref ID J:166647]

Patel DR; Li W; Park JS; Sofi MH; Gourley TS; Hangoc G; Kaplan MH; Chang CH. 2005. Constitutive expression of CIITA directs CD4 T cells to produce Th2 cytokines in the thymus. Cell Immunol 233(1):30-40. [PubMed: 15876426]  [MGI Ref ID J:99357]

Perona-Wright G; Mohrs K; Mayer KD; Mohrs M. 2010. Differential regulation of IL-4Ralpha expression by antigen versus cytokine stimulation characterizes Th2 progression in vivo. J Immunol 184(2):615-23. [PubMed: 20018622]  [MGI Ref ID J:159399]

Perona-Wright G; Mohrs K; Mohrs M. 2010. Sustained signaling by canonical helper T cell cytokines throughout the reactive lymph node. Nat Immunol 11(6):520-6. [PubMed: 20418876]  [MGI Ref ID J:160618]

Rao RR; Long JZ; White JP; Svensson KJ; Lou J; Lokurkar I; Jedrychowski MP; Ruas JL; Wrann CD; Lo JC; Camera DM; Lachey J; Gygi S; Seehra J; Hawley JA; Spiegelman BM. 2014. Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell 157(6):1279-91. [PubMed: 24906147]  [MGI Ref ID J:211329]

Reece JJ; Siracusa MC; Southard TL; Brayton CF; Urban JF Jr; Scott AL. 2008. Hookworm-induced persistent changes to the immunological environment of the lung. Infect Immun 76(8):3511-24. [PubMed: 18505812]  [MGI Ref ID J:139393]

Reese TA; Liang HE; Tager AM; Luster AD; Van Rooijen N; Voehringer D; Locksley RM. 2007. Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature 447(7140):92-6. [PubMed: 17450126]  [MGI Ref ID J:122735]

Ricardo-Gonzalez RR; Red Eagle A; Odegaard JI; Jouihan H; Morel CR; Heredia JE; Mukundan L; Wu D; Locksley RM; Chawla A. 2010. IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity. Proc Natl Acad Sci U S A 107(52):22617-22. [PubMed: 21149710]  [MGI Ref ID J:167288]

Riella LV; Ueno T; Batal I; De Serres SA; Bassil R; Elyaman W; Yagita H; Medina-Pestana JO; Chandraker A; Najafian N. 2011. Blockade of Notch ligand Delta1 promotes allograft survival by inhibiting alloreactive Th1 cells and cytotoxic T cell generation. J Immunol 187(9):4629-38. [PubMed: 21949024]  [MGI Ref ID J:179438]

Rodriguez M; Zoecklein L; Gamez JD; Pavelko KD; Papke LM; Nakane S; Howe C; Radhakrishnan S; Hansen MJ; David CS; Warrington AE; Pease LR. 2006. STAT4- and STAT6-signaling molecules in a murine model of multiple sclerosis. FASEB J 20(2):343-5. [PubMed: 16352646]  [MGI Ref ID J:105734]

Rodriguez-Galan MC; Bream JH; Farr A; Young HA. 2005. Synergistic effect of IL-2, IL-12, and IL-18 on thymocyte apoptosis and Th1/Th2 cytokine expression. J Immunol 174(5):2796-804. [PubMed: 15728489]  [MGI Ref ID J:97710]

Rodriguez-Sosa M; David JR; Bojalil R; Satoskar AR; Terrazas LI. 2002. Cutting edge: susceptibility to the larval stage of the Helminth parasite Taenia crassiceps is mediated by Th2 response induced via STAT6 signaling. J Immunol 168(7):3135-9. [PubMed: 11907063]  [MGI Ref ID J:75481]

Rosas LE; Keiser T; Barbi J; Satoskar AA; Septer A; Kaczmarek J; Lezama-Davila CM; Satoskar AR. 2005. Genetic background influences immune responses and disease outcome of cutaneous L. mexicana infection in mice. Int Immunol 17(10):1347-57. [PubMed: 16141242]  [MGI Ref ID J:101701]

Rose S; Guevara P; Farach S; Adkins B. 2006. The key regulators of adult T helper cell responses, STAT6 and T-bet, are established in early life in mice. Eur J Immunol 36(5):1241-53. [PubMed: 16568497]  [MGI Ref ID J:114781]

Rosen MJ; Chaturvedi R; Washington MK; Kuhnhein LA; Moore PD; Coggeshall SS; McDonough EM; Weitkamp JH; Singh AB; Coburn LA; Williams CS; Yan F; Van Kaer L; Peebles RS Jr; Wilson KT. 2013. STAT6 Deficiency Ameliorates Severity of Oxazolone Colitis by Decreasing Expression of Claudin-2 and Th2-Inducing Cytokines. J Immunol 190(4):1849-58. [PubMed: 23303670]  [MGI Ref ID J:193252]

Ruschmann J; Ho V; Antignano F; Kuroda E; Lam V; Ibaraki M; Snyder K; Kim C; Flavell RA; Kawakami T; Sly L; Turhan AG; Krystal G. 2010. Tyrosine phosphorylation of SHIP promotes its proteasomal degradation. Exp Hematol 38(5):392-402, 402.e1. [PubMed: 20304029]  [MGI Ref ID J:164034]

Sanchez-Guajardo V; Borghans JA; Marquez ME; Garcia S; Freitas AA. 2005. Different competitive capacities of Stat4- and Stat6-deficient CD4+ T cells during lymphophenia-driven proliferation. J Immunol 174(3):1178-87. [PubMed: 15661871]  [MGI Ref ID J:96425]

Sanchez-Guajardo V; Tanchot C; O'Malley JT; Kaplan MH; Garcia S; Freitas AA. 2007. Agonist-driven development of CD4+CD25+Foxp3+ regulatory T cells requires a second signal mediated by Stat6. J Immunol 178(12):7550-6. [PubMed: 17548589]  [MGI Ref ID J:148595]

Saraiva M; Christensen JR; Veldhoen M; Murphy TL; Murphy KM; O'Garra A. 2009. Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose. Immunity 31(2):209-19. [PubMed: 19646904]  [MGI Ref ID J:151873]

Sasaki K; Zhao X; Pardee AD; Ueda R; Fujita M; Sehra S; Kaplan MH; Kane LP; Okada H; Storkus WJ. 2008. Stat6 signaling suppresses VLA-4 expression by CD8+ T cells and limits their ability to infiltrate tumor lesions in vivo. J Immunol 181(1):104-8. [PubMed: 18566374]  [MGI Ref ID J:137362]

Schilte C; Couderc T; Chretien F; Sourisseau M; Gangneux N; Guivel-Benhassine F; Kraxner A; Tschopp J; Higgs S; Michault A; Arenzana-Seisdedos F; Colonna M; Peduto L; Schwartz O; Lecuit M; Albert ML. 2010. Type I IFN controls chikungunya virus via its action on nonhematopoietic cells. J Exp Med 207(2):429-42. [PubMed: 20123960]  [MGI Ref ID J:157759]

Sehra S; Patel D; Kusam S; Wang ZY; Chang CH; Dent AL. 2005. A role for caspases in controlling IL-4 expression in T cells. J Immunol 174(6):3440-6. [PubMed: 15749878]  [MGI Ref ID J:128888]

Sesti-Costa R; Silva GK; Proenca-Modena JL; Carlos D; Silva ML; Alves-Filho JC; Arruda E; Liew FY; Silva JS. 2013. The IL-33/ST2 pathway controls coxsackievirus B5-induced experimental pancreatitis. J Immunol 191(1):283-92. [PubMed: 23733876]  [MGI Ref ID J:205354]

Shen R; Kaplan MH. 2002. The homeostasis but not the differentiation of T cells is regulated by p27(Kip1). J Immunol 169(2):714-21. [PubMed: 12097373]  [MGI Ref ID J:123837]

Shen XD; Ke B; Zhai Y; Gao F; Anselmo D; Lassman CR; Busuttil RW; Kupiec-Weglinski JW. 2003. Stat4 and Stat6 signaling in hepatic ischemia/reperfusion injury in mice: HO-1 dependence of Stat4 disruption-mediated cytoprotection. Hepatology 37(2):296-303. [PubMed: 12540779]  [MGI Ref ID J:105818]

Shi HN; Grusby MJ; Nagler-Anderson C. 1999. Orally induced peripheral nonresponsiveness is maintained in the absence of functional Th1 or Th2 cells. J Immunol 162(9):5143-8. [PubMed: 10227985]  [MGI Ref ID J:112262]

Shirey KA; Cole LE; Keegan AD; Vogel SN. 2008. Francisella tularensis live vaccine strain induces macrophage alternative activation as a survival mechanism. J Immunol 181(6):4159-67. [PubMed: 18768873]  [MGI Ref ID J:139088]

Sho M; Yamada A; Najafian N; Salama AD; Harada H; Sandner SE; Sanchez-Fueyo A; Zheng XX; Strom TB; Sayegh MH. 2002. Physiological mechanisms of regulating alloimmunity: cytokines, CTLA-4, CD25+ cells, and the alloreactive T cell clone size. J Immunol 169(7):3744-51. [PubMed: 12244168]  [MGI Ref ID J:120408]

Simovic MO; Ballard BR; Gray KD; Stain SC. 2007. The STAT4 and STAT6 pathways in pancreatitis-associated lung injury. J Surg Res 137(1):10-5. [PubMed: 17109890]  [MGI Ref ID J:128064]

Singh RR; Saxena V; Zang S; Li L; Finkelman FD; Witte DP; Jacob CO. 2003. Differential contribution of IL-4 and STAT6 vs STAT4 to the development of lupus nephritis. J Immunol 170(9):4818-25. [PubMed: 12707364]  [MGI Ref ID J:123824]

Sinha P; Clements VK; Ostrand-Rosenberg S. 2005. Interleukin-13-regulated M2 macrophages in combination with myeloid suppressor cells block immune surveillance against metastasis. Cancer Res 65(24):11743-51. [PubMed: 16357187]  [MGI Ref ID J:104344]

Sofi MH; Liu Z; Zhu L; Yu Q; Kaplan MH; Chang CH. 2010. Regulation of IL-17 expression by the developmental pathway of CD4 T cells in the thymus. Mol Immunol 47(6):1262-8. [PubMed: 20080304]  [MGI Ref ID J:158374]

Solymar DC; Agarwal S; Bassing CH; Alt FW; Rao A. 2002. A 3' enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells. Immunity 17(1):41-50. [PubMed: 12150890]  [MGI Ref ID J:78089]

Speiran K; Bailey DP; Fernando J; Macey M; Barnstein B; Kolawole M; Curley D; Watowich SS; Murray PJ; Oskeritzian C; Ryan JJ. 2009. Endogenous suppression of mast cell development and survival by IL-4 and IL-10. J Leukoc Biol 85(5):826-36. [PubMed: 19228815]  [MGI Ref ID J:149777]

Spencer L; Shultz L; Rajan TV. 2001. Interleukin-4 receptor-stat6 signaling in murine infections with a tissue-dwelling nematode parasite. Infect Immun 69(12):7743-52. [PubMed: 11705956]  [MGI Ref ID J:73137]

Stanya KJ; Jacobi D; Liu S; Bhargava P; Dai L; Gangl MR; Inouye K; Barlow JL; Ji Y; Mizgerd JP; Qi L; Shi H; McKenzie AN; Lee CH. 2013. Direct control of hepatic glucose production by interleukin-13 in mice. J Clin Invest 123(1):261-71. [PubMed: 23257358]  [MGI Ref ID J:194510]

Strait RT; Morris SC; Smiley K; Urban JF Jr; Finkelman FD. 2003. IL-4 exacerbates anaphylaxis. J Immunol 170(7):3835-42. [PubMed: 12646651]  [MGI Ref ID J:125442]

Su CW; Cao Y; Kaplan J; Zhang M; Li W; Conroy M; Walker WA; Shi HN. 2011. Duodenal Helminth Infection Alters Barrier Function of the Colonic Epithelium via Adaptive Immune Activation. Infect Immun 79(6):2285-94. [PubMed: 21444669]  [MGI Ref ID J:171918]

Su CW; Cao Y; Zhang M; Kaplan J; Su L; Fu Y; Walker WA; Xavier R; Cherayil BJ; Shi HN. 2012. Helminth infection impairs autophagy-mediated killing of bacterial enteropathogens by macrophages. J Immunol 189(3):1459-66. [PubMed: 22732589]  [MGI Ref ID J:189786]

Summers SA; Phoon RK; Odobasic D; Dewage L; Kitching AR; Holdsworth SR. 2011. Signal transducer and activation of transcription 6 (STAT6) regulates T helper type 1 (Th1) and Th17 nephritogenic immunity in experimental crescentic glomerulonephritis. Clin Exp Immunol 166(2):227-34. [PubMed: 21985369]  [MGI Ref ID J:177863]

Suscovich TJ; Perdue NR; Campbell DJ. 2012. Type-1 immunity drives early lethality in scurfy mice. Eur J Immunol 42(9):2305-10. [PubMed: 22740092]  [MGI Ref ID J:187940]

Suzukawa M; Miller M; Rosenthal P; Cho JY; Doherty TA; Varki A; Broide D. 2013. Sialyltransferase ST3Gal-III regulates Siglec-F ligand formation and eosinophilic lung inflammation in mice. J Immunol 190(12):5939-48. [PubMed: 23677475]  [MGI Ref ID J:204846]

Swain SD; Meissner NN; Siemsen DW; McInnerney K; Harmsen AG. 2012. Pneumocystis elicits a STAT6-dependent, strain-specific innate immune response and airway hyperresponsiveness. Am J Respir Cell Mol Biol 46(3):290-8. [PubMed: 21960549]  [MGI Ref ID J:194583]

Swain SD; Siemsen DW; Pullen RR; Han S. 2014. CD4+ T cells and IFN-gamma are required for the development of Pneumocystis-associated pulmonary hypertension. Am J Pathol 184(2):483-93. [PubMed: 24361497]  [MGI Ref ID J:206386]

Szanto A; Balint BL; Nagy ZS; Barta E; Dezso B; Pap A; Szeles L; Poliska S; Oros M; Evans RM; Barak Y; Schwabe J; Nagy L. 2010. STAT6 transcription factor is a facilitator of the nuclear receptor PPARgamma-regulated gene expression in macrophages and dendritic cells. Immunity 33(5):699-712. [PubMed: 21093321]  [MGI Ref ID J:167002]

Takahashi H; Kanno T; Nakayamada S; Hirahara K; Sciume G; Muljo SA; Kuchen S; Casellas R; Wei L; Kanno Y; O'Shea JJ. 2012. TGF-beta and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells. Nat Immunol 13(6):587-95. [PubMed: 22544395]  [MGI Ref ID J:186450]

Tarleton RL; Grusby MJ; Zhang L. 2000. Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi. J Immunol 165(3):1520-5. [PubMed: 10903759]  [MGI Ref ID J:120438]

Tawara I; Maeda Y; Sun Y; Lowler KP; Liu C; Toubai T; McKenzie AN; Reddy P. 2008. Combined Th2 cytokine deficiency in donor T cells aggravates experimental acute graft-vs-host disease. Exp Hematol 36(8):988-96. [PubMed: 18410989]  [MGI Ref ID J:139377]

Tekkanat KK; Maassab HF; Cho DS; Lai JJ; John A; Berlin A; Kaplan MH; Lukacs NW. 2001. IL-13-induced airway hyperreactivity during respiratory syncytial virus infection is STAT6 dependent. J Immunol 166(5):3542-8. [PubMed: 11207314]  [MGI Ref ID J:126450]

Temann UA; Laouar Y; Eynon EE; Homer R; Flavell RA. 2007. IL9 leads to airway inflammation by inducing IL13 expression in airway epithelial cells. Int Immunol 19(1):1-10. [PubMed: 17101709]  [MGI Ref ID J:118163]

Terabe M; Khanna C; Bose S; Melchionda F; Mendoza A; Mackall CL; Helman LJ; Berzofsky JA. 2006. CD1d-restricted natural killer T cells can down-regulate tumor immunosurveillance independent of interleukin-4 receptor-signal transducer and activator of transcription 6 or transforming growth factor-beta. Cancer Res 66(7):3869-75. [PubMed: 16585215]  [MGI Ref ID J:108313]

Turnbull IR; Gilfillan S; Cella M; Aoshi T; Miller M; Piccio L; Hernandez M; Colonna M. 2006. Cutting edge: TREM-2 attenuates macrophage activation. J Immunol 177(6):3520-4. [PubMed: 16951310]  [MGI Ref ID J:138057]

Ueno A; Cho S; Cheng L; Wang J; Hou S; Nakano H; Santamaria P; Yang Y. 2007. Transient upregulation of indoleamine 2,3-dioxygenase in dendritic cells by human chorionic gonadotropin downregulates autoimmune diabetes. Diabetes 56(6):1686-93. [PubMed: 17360980]  [MGI Ref ID J:126514]

Ueno T; Habicht A; Clarkson MR; Albin MJ; Yamaura K; Boenisch O; Popoola J; Wang Y; Yagita H; Akiba H; Ansari MJ; Yang J; Turka LA; Rothstein DM; Padera RF; Najafian N; Sayegh MH. 2008. The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model. J Clin Invest 118(2):742-51. [PubMed: 18172549]  [MGI Ref ID J:131045]

Van Dyken SJ; Mohapatra A; Nussbaum JC; Molofsky AB; Thornton EE; Ziegler SF; McKenzie AN; Krummel MF; Liang HE; Locksley RM. 2014. Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and gammadelta T cells. Immunity 40(3):414-24. [PubMed: 24631157]  [MGI Ref ID J:210323]

Van den Bossche J; Bogaert P; van Hengel J; Guerin CJ; Berx G; Movahedi K; Van den Bergh R; Pereira-Fernandes A; Geuns JM; Pircher H; Dorny P; Grooten J; De Baetselier P; Van Ginderachter JA. 2009. Alternatively activated macrophages engage in homotypic and heterotypic interactions through IL-4 and polyamine-induced E-cadherin/catenin complexes. Blood 114(21):4664-74. [PubMed: 19726720]  [MGI Ref ID J:155503]

Villarino AV; Tato CM; Stumhofer JS; Yao Z; Cui YK; Hennighausen L; O'Shea JJ; Hunter CA. 2007. Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals. J Exp Med 204(1):65-71. [PubMed: 17227909]  [MGI Ref ID J:125293]

Voehringer D; Reese TA; Huang X; Shinkai K; Locksley RM. 2006. Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system. J Exp Med 203(6):1435-46. [PubMed: 16702603]  [MGI Ref ID J:124383]

Voehringer D; Stanley SA; Cox JS; Completo GC; Lowary TL; Locksley RM. 2007. Nippostrongylus brasiliensis: identification of intelectin-1 and -2 as Stat6-dependent genes expressed in lung and intestine during infection. Exp Parasitol 116(4):458-66. [PubMed: 17420014]  [MGI Ref ID J:128858]

Wang J; Cho S; Ueno A; Cheng L; Xu BY; Desrosiers MD; Shi Y; Yang Y. 2008. Ligand-dependent induction of noninflammatory dendritic cells by anergic invariant NKT cells minimizes autoimmune inflammation. J Immunol 181(4):2438-45. [PubMed: 18684934]  [MGI Ref ID J:140188]

Wang W; Ostlie NS; Conti-Fine BM; Milani M. 2004. The susceptibility to experimental myasthenia gravis of STAT6-/- and STAT4-/- BALB/c mice suggests a pathogenic role of Th1 cells. J Immunol 172(1):97-103. [PubMed: 14688314]  [MGI Ref ID J:87570]

Wang ZY; Kusam S; Munugalavadla V; Kapur R; Brutkiewicz RR; Dent AL. 2006. Regulation of Th2 cytokine expression in NKT cells: unconventional use of Stat6, GATA-3, and NFAT2. J Immunol 176(2):880-8. [PubMed: 16393972]  [MGI Ref ID J:126448]

Weng M; Huntley D; Huang IF; Foye-Jackson O; Wang L; Sarkissian A; Zhou Q; Walker WA; Cherayil BJ; Shi HN. 2007. Alternatively activated macrophages in intestinal helminth infection: effects on concurrent bacterial colitis. J Immunol 179(7):4721-31. [PubMed: 17878371]  [MGI Ref ID J:152339]

Wermeling F; Anthony RM; Brombacher F; Ravetch JV. 2013. Acute inflammation primes myeloid effector cells for anti-inflammatory STAT6 signaling. Proc Natl Acad Sci U S A 110(33):13487-91. [PubMed: 23898202]  [MGI Ref ID J:200690]

Xu J; Yang Y; Qiu G; Lal G; Yin N; Wu Z; Bromberg JS; Ding Y. 2011. Stat4 Is Critical for the Balance between Th17 Cells and Regulatory T Cells in Colitis. J Immunol 186(11):6597-606. [PubMed: 21525389]  [MGI Ref ID J:173182]

Xu Z; Duan B; Croker BP; Morel L. 2006. STAT4 deficiency reduces autoantibody production and glomerulonephritis in a mouse model of lupus. Clin Immunol 120(2):189-98. [PubMed: 16713741]  [MGI Ref ID J:113234]

Yadav MC; Burudi EM; Alirezaei M; Flynn CC; Watry DD; Lanigan CM; Fox HS. 2007. IFN-gamma-induced IDO and WRS expression in microglia is differentially regulated by IL-4. Glia 55(13):1385-96. [PubMed: 17661345]  [MGI Ref ID J:156302]

Yamada A; Sheikh F; Niimi T; DeMayo FJ; Keegan AD; Donnelly RP; Kimura S. 2005. Induction of uteroglobin-related protein 2 (Ugrp2) gene expression by the Th2 cytokines IL-4 and IL-13. J Immunol 175(9):5708-15. [PubMed: 16237061]  [MGI Ref ID J:119343]

Yamaji-Kegan K; Su Q; Angelini DJ; Johns RA. 2009. IL-4 is proangiogenic in the lung under hypoxic conditions. J Immunol 182(9):5469-76. [PubMed: 19380795]  [MGI Ref ID J:147713]

Yamaji-Kegan K; Su Q; Angelini DJ; Myers AC; Cheadle C; Johns RA. 2010. Hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELMalpha) increases lung inflammation and activates pulmonary microvascular endothelial cells via an IL-4-dependent mechanism. J Immunol 185(9):5539-48. [PubMed: 20889544]  [MGI Ref ID J:165183]

Yang XO; Zhang H; Kim BS; Niu X; Peng J; Chen Y; Kerketta R; Lee YH; Chang SH; Corry DB; Wang D; Watowich SS; Dong C. 2013. The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation. Nat Immunol 14(7):732-40. [PubMed: 23727894]  [MGI Ref ID J:204829]

Yang Y; Xu J; Niu Y; Bromberg JS; Ding Y. 2008. T-bet and Eomesodermin play critical roles in directing T cell differentiation to Th1 versus Th17. J Immunol 181(12):8700-10. [PubMed: 19050290]  [MGI Ref ID J:142051]

Yang Z; Grinchuk V; Urban JF Jr; Bohl J; Sun R; Notari L; Yan S; Ramalingam T; Keegan AD; Wynn TA; Shea-Donohue T; Zhao A. 2013. Macrophages as IL-25/IL-33-responsive cells play an important role in the induction of type 2 immunity. PLoS One 8(3):e59441. [PubMed: 23536877]  [MGI Ref ID J:199899]

Yang Z; Sun R; Grinchuk V; Blanco JA; Notari L; Bohl JA; McLean LP; Ramalingam TR; Wynn TA; Urban JF Jr; Vogel SN; Shea-Donohue T; Zhao A. 2013. IL-33-induced alterations in murine intestinal function and cytokine responses are MyD88, STAT6, and IL-13 dependent. Am J Physiol Gastrointest Liver Physiol 304(4):G381-9. [PubMed: 23257921]  [MGI Ref ID J:194946]

Yao Y; Li W; Kaplan MH; Chang CH. 2005. Interleukin (IL)-4 inhibits IL-10 to promote IL-12 production by dendritic cells. J Exp Med 201(12):1899-903. [PubMed: 15967820]  [MGI Ref ID J:99206]

Yeung MY; McGrath MM; Nakayama M; Shimizu T; Boenisch O; Magee CN; Abdoli R; Akiba H; Ueno T; Turka LA; Najafian N. 2013. Interruption of dendritic cell-mediated TIM-4 signaling induces regulatory T cells and promotes skin allograft survival. J Immunol 191(8):4447-55. [PubMed: 24038092]  [MGI Ref ID J:206275]

Yokota N; Burne-Taney M; Racusen L; Rabb H. 2003. Contrasting roles for STAT4 and STAT6 signal transduction pathways in murine renal ischemia-reperfusion injury. Am J Physiol Renal Physiol 285(2):F319-25. [PubMed: 12709397]  [MGI Ref ID J:84825]

Yu Q; Chang HC; Ahyi AN; Kaplan MH. 2008. Transcription factor-dependent chromatin remodeling of Il18r1 during Th1 and Th2 differentiation. J Immunol 181(5):3346-52. [PubMed: 18714006]  [MGI Ref ID J:138949]

Zaph C; Du Y; Saenz SA; Nair MG; Perrigoue JG; Taylor BC; Troy AE; Kobuley DE; Kastelein RA; Cua DJ; Yu Y; Artis D. 2008. Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine. J Exp Med 205(10):2191-8. [PubMed: 18762568]  [MGI Ref ID J:141183]

Zeiser R; Youssef S; Baker J; Kambham N; Steinman L; Negrin RS. 2007. Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th-2 polarization while sparing graft-versus-leukemia activity. Blood 110(13):4588-98. [PubMed: 17827390]  [MGI Ref ID J:149097]

Zhang S; Lawless VA; Kaplan MH. 2000. Cytokine-stimulated T lymphocyte proliferation is regulated by p27Kip1. J Immunol 165(11):6270-7. [PubMed: 11086062]  [MGI Ref ID J:112128]

Zhang Y; Kirken RA; Furian L; Janczewska S; Qu X; Hancock WW; Wang M; Tejpal N; Kerman R; Kahan BD; Stepkowski SM. 2006. Allograft rejection requires STAT5a/b-regulated antiapoptotic activity in T cells but not B cells. J Immunol 176(1):128-37. [PubMed: 16365403]  [MGI Ref ID J:126249]

Zhao A; Morimoto M; Dawson H; Elfrey JE; Madden KB; Gause WC; Min B; Finkelman FD; Urban JF Jr; Shea-Donohue T. 2005. Immune regulation of protease-activated receptor-1 expression in murine small intestine during Nippostrongylus brasiliensis infection. J Immunol 175(4):2563-9. [PubMed: 16081830]  [MGI Ref ID J:107492]

Zhao A; Urban JF Jr; Sun R; Stiltz J; Morimoto M; Notari L; Madden KB; Yang Z; Grinchuk V; Ramalingam TR; Wynn TA; Shea-Donohue T. 2010. Critical role of IL-25 in nematode infection-induced alterations in intestinal function. J Immunol 185(11):6921-9. [PubMed: 20974983]  [MGI Ref ID J:167370]

Zhao A; Yang Z; Sun R; Grinchuk V; Netzel-Arnett S; Anglin IE; Driesbaugh KH; Notari L; Bohl JA; Madden KB; Urban JF Jr; Antalis TM; Shea-Donohue T. 2013. SerpinB2 is critical to Th2 immunity against enteric nematode infection. J Immunol 190(11):5779-87. [PubMed: 23630350]  [MGI Ref ID J:204777]

Zhong J; Yang P; Muta K; Dong R; Marrero M; Gong F; Wang CY. 2010. Loss of Jak2 selectively suppresses DC-mediated innate immune response and protects mice from lethal dose of LPS-induced septic shock. PLoS One 5(3):e9593. [PubMed: 20231889]  [MGI Ref ID J:158917]

Zhou B; Headley MB; Aye T; Tocker J; Comeau MR; Ziegler SF. 2008. Reversal of thymic stromal lymphopoietin-induced airway inflammation through inhibition of Th2 responses. J Immunol 181(9):6557-62. [PubMed: 18941246]  [MGI Ref ID J:140715]

Zhou P; Szot GL; Guo Z; Kim O; He G; Wang J; Grusby MJ; Newell KA; Thistlethwaite JR; Bluestone JA; Alegre ML. 2000. Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance. J Immunol 165(10):5580-7. [PubMed: 11067913]  [MGI Ref ID J:119580]

Zhu B; Buttrick T; Bassil R; Zhu C; Olah M; Wu C; Xiao S; Orent W; Elyaman W; Khoury SJ. 2013. IL-4 and retinoic acid synergistically induce regulatory dendritic cells expressing Aldh1a2. J Immunol 191(6):3139-51. [PubMed: 23960232]  [MGI Ref ID J:205869]

Zhu J; Guo L; Min B; Watson CJ; Hu-Li J; Young HA; Tsichlis PN; Paul WE. 2002. Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation. Immunity 16(5):733-44. [PubMed: 12049724]  [MGI Ref ID J:113530]

Zimmermann N; Mishra A; King NE; Fulkerson PC; Doepker MP; Nikolaidis NM; Kindinger LE; Moulton EA; Aronow BJ; Rothenberg ME. 2004. Transcript signatures in experimental asthma: identification of STAT6-dependent and -independent pathways. J Immunol 172(3):1815-24. [PubMed: 14734765]  [MGI Ref ID J:107368]

van Panhuys N; Prout M; Forbes E; Min B; Paul WE; Le Gros G. 2011. Basophils Are the Major Producers of IL-4 during Primary Helminth Infection. J Immunol 186(5):2719-28. [PubMed: 21270410]  [MGI Ref ID J:169387]

van Panhuys N; Tang SC; Prout M; Camberis M; Scarlett D; Roberts J; Hu-Li J; Paul WE; Le Gros G. 2008. In vivo studies fail to reveal a role for IL-4 or STAT6 signaling in Th2 lymphocyte differentiation. Proc Natl Acad Sci U S A 105(34):12423-8. [PubMed: 18719110]  [MGI Ref ID J:138827]

van der Merwe M; Abdelsamed HA; Seth A; Ong T; Vogel P; Pillai AB. 2013. Recipient myeloid-derived immunomodulatory cells induce PD-1 ligand-dependent donor CD4+Foxp3+ regulatory T cell proliferation and donor-recipient immune tolerance after murine nonmyeloablative bone marrow transplantation. J Immunol 191(11):5764-76. [PubMed: 24190658]  [MGI Ref ID J:207149]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX10

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, these mice are bred as homozygotes.
Mating SystemHomozygote x Homozygote         (Female x Male)   12-JUN-06
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $199.90Female or MaleHomozygous for Stat6tm1Gru  
Price per Pair (US dollars $)Pair Genotype
$399.80Homozygous for Stat6tm1Gru x Homozygous for Stat6tm1Gru  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $259.90Female or MaleHomozygous for Stat6tm1Gru  
Price per Pair (US dollars $)Pair Genotype
$519.80Homozygous for Stat6tm1Gru x Homozygous for Stat6tm1Gru  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.8)