Strain Name: |
B6.Cg-Tg(Prnp-APP)A-2Dbo/J |
|---|---|
Stock Number: |
006006 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Genes & Alleles | APP; Prnp; Tg(Prnp-APP)A-2Dbo; |
Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Type JAX® GEMM® Strain - Transgenic Species laboratory mouse Donating Investigator David Borchelt, McKnight Brain Inst, Univ of Florida Strain Description
These transgenic mice express the human amyloid precursor protein (APP) under the control of the mouse prion protein promoter. Mice that are hemizygous for the transgene are viable and fertile. This mutant mouse strain may be useful in studies of Alzheimer's Disease.Strain Development
A transgenic construct containing the human amyloid precursor protein (APP) under the control of the mouse prion protein promoter was injected into fertilized C57BL/6J mouse eggs. Founder line A-2 was established. The mice were then maintained by crossing hemizgyous male mice to C57BL/6J female mice.
Related Disease (OMIM) Terms |
Mammalian Phenotype Terms assigned by genotype |
| Allele Symbol | Tg(Prnp-APP)A-2Dbo | ||
|---|---|---|---|
| Allele Name | transgene insertion A-2, David R Borchelt | ||
| Strain of Origin | C57BL/6 | ||
| Expressed Gene | APP, amyloid beta (A4) precursor protein, human | ||
| Promoter | Prnp, prion protein, mouse, laboratory | ||
| Molecular Note | Mice with this transgene express the human amyloid precursor protein (APP) under control of the mouse prion protein promoter. [MGI Ref ID J:117538] | ||
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Tg(APP)
| Breeding & Husbandry | When maintaining a live colony, these mice are bred as hemizygotes. |
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Strains carrying other alleles of APP
006409 129S1.Cg-Tg(APPSw)40Btla/J 006555 A.129(B6)-Tg(APPSw)40Btla/J 005300 B6.129-Tg(APPSw)40Btla/J 005301 B6.129S2-Tg(APP)8.9Btla/J 006406 B6.129S4-Tg(APPSwLon)96Btla/J 005864 B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/J 004662 B6.Cg-Tg(PDGFB-APP)5Lms/J 004661 B6.Cg-Tg(PDGFB-APPSwInd)20Lms/1J 006293 B6.Cg-Tg(PDGFB-APPSwInd)20Lms/2J 006005 B6.Cg-Tg(Prnp-App/APPswe)E1-2Dbo/J 007049 B6.Cg-Tg(tetO-APPSwInd)885Dbo/J 004462 B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J 006004 B6C3-Tg(tetO-APPSwInd)885Dbo/J 007027 C57BL/6-Tg(Thy1-APPSwDutIowa)BWevn/J 006472 D2.129(B6)-Tg(APPSw)40Btla/J View Strains carrying other alleles of APP (15 strains)
Strains carrying other alleles of Prnp
View Strains carrying other alleles of Prnp (18 strains)
Visit the Alzheimer's Disease Mouse Model Resource site for helpful information on Alzheimer's Disease and research resources.
APP relatedNeurobiology Research
Alzheimer's Disease
Mouse/Human Gene Homologs
Alzheimer's
Neurobiology Research
Alzheimer's Disease
Neurodegeneration
| Strain Name: | B6.Cg-Tg(Prnp-APP)A-2Dbo/J |
| Stock Number: | 006006 |
IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below for Licensing and Use Restrictions |
| Control Information | View Control Information in Strain Details. |
For additional Licensing and Use Restrictions view the link(s) below:
- Strain(s) not available to companies or for-profit entities.
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