Strain Name:

NOD.Cg-Rag1tm1Mom H2-Ab1tm1Gru Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell/EllJ

Stock Number:

006024

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Availability:

Cryopreserved - Ready for recovery

Use Restrictions Apply, see Terms of Use

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names NOD.Cg-Rag1tm1Mom H2-Ab1tm1Gru Tg(CD4,HLA-DQA1*0102,HLA-DQB1*0602)1Ell/EllJ    (Changed: 07-NOV-06 )
NOD.Cg-Rag1tm1Mom H2-Ab1tm1Gru Tg(CD4, HLA-DQA*0102, HLA-DQB*0602)1Ell/EllJ    (Changed: 26-JAN-06 )
NOD.Cg-Rag1tm1Mom Ab1tm1Gru Tg(CD4, HLA-DQA*0102, HLA-DQB*0602)1Ell/EllJ    (Changed: 25-JAN-06 )
Type Congenic; Mutant Strain; Targeted Mutation; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Background Strain NOD/ShiLtJ
H2 Haplotypeg7
Generation?+F1p
Generation Definitions
 
Donating Investigator John Elliott,   University of Alberta

Appearance
pink-eyed, albino

Description
Rag1 and H2-Ab1 deficient NOD mice carrying transgenes encoding humanized CD4 and HLA-DQ6 lack T and B cells and are free of autoimmune diabetes and cardiomyopathy, and do not develop thyroiditis.

This model is useful in adoptive transfer experiments and in studying MHC class II-based resistance and susceptibility in autoimmunity.

Development
Congenic, H2-Ab1 deficient, NOD mice carrying transgenes encoding CD4 and a human genomic fragment containing the entire HLA-DQ6 gene (DQA1*0102, DQB1*0602, Stock No. 006023) were crossed to congenic Rag1 deficient NOD mice (Stock No. 003729), and were bred to homozygosity for the H2-Ab1tm1Gru and Rag1tm1Mom targeted mutations. The T1DR received this strain in 2006.

Control Information

  Control
   001976 NOD/ShiLtJ
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying   H2-Ab1tm1Gru     (7 strains)

View Strains carrying   Rag1tm1Mom     (24 strains)

Strains carrying   Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell allele
006023   NOD.Cg-H2-Ab1tm1Gru Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell/EllJ
View Strains carrying   Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell     (1 strain)

View Strains carrying other alleles of CD4     (3 strains)

View Strains carrying other alleles of H2-Ab1     (9 strains)

View Strains carrying other alleles of HLA-DQA1     (3 strains)

View Strains carrying other alleles of HLA-DQB1     (3 strains)

Strains carrying other alleles of Rag1
007790   B6;129P2-Rag1/Rag2tm1Mnz/J
View Strains carrying other alleles of Rag1     (1 strain)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Alpha/Beta T-Cell Lymphopenia with Gamma/Delta T-Cell Expansion, Severe Cytomegalovirus Infection, and Autoimmunity   (RAG1)
Celiac Disease; CD   (HLA-DQB1)
Combined Cellular and Humoral Immune Defects with Granulomas; CCHIDG   (RAG1)
Creutzfeldt-Jakob Disease; CJD   (HLA-DQB1)
Multiple Sclerosis, Susceptibility To; MS   (HLA-DQB1)
Omenn Syndrome   (RAG1)
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Positive   (RAG1)
- Potential model based on transgenic expression of an ortholog of a human gene that is associated with this disease. Phenotypic similarity to the human disease has not been tested.
Okt4 Epitope Deficiency   (CD4)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
Islet Transplantation Studies
Type 1 Diabetes (IDDM) Analysis Strains
      NOD Congenics with Mutations Affecting Immunocompetence
      NOD Transgenics

Immunology, Inflammation and Autoimmunity Research
HLA transgenics
Immunodeficiency
      MHC class II deficient

Research Tools
Immunology, Inflammation and Autoimmunity Research
      MHC class II defects

H2-Ab1tm1Gru related

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency

Rag1tm1Mom related

Cancer Research
Toxicology
      B and T cell deficiency, xenograft/transplant host

Hematological Research
Immunological Defects
      B and T cell deficiency

Immunology, Inflammation and Autoimmunity Research
Immunodeficiency
      B and T cell deficiency
Inflammation
      B and T cell deficiency
T Cell Receptor Signaling Defects
      B and T cell deficiency

Internal/Organ Research
Lymphoid Tissue Defects
      B and T cell deficiency

Research Tools
Cancer Research
      B and T cell deficiency, xenograft/transplant host
Toxicology Research
      xenograft/transplant host

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol H2-Ab1tm1Gru
Allele Name targeted mutation 1, Michael J Grusby
Allele Type Targeted (Null/Knockout)
Common Name(s) Abbeta-; Ab1tm1Gru; Abb-; Abbtm1; Abeta-; Abetab-; C2-; H2-Ab1-; H2-Ab1tm1Glm; I-Ab-; I-Abetab-; IAb-; IAbeta-; MHC class II-; MHC-II-deficient; [KO]Abb; mII-;
Mutation Made ByDr. Michael Grusby,   Harvard Medical School
Strain of Origin129S2/SvPas
ES Cell Line NameD3
ES Cell Line Strain129S2/SvPas
Gene Symbol and Name H2-Ab1, histocompatibility 2, class II antigen A, beta 1
Chromosome 17
Gene Common Name(s) A beta; AI845868; Abeta; Bb; CELIAC1; H-2Ab; H2-Ab; HLA-DQB; I-Ab; I-Abeta; I-region-associated antigen 2; IAb; IDDM1; Ia-2; Ia2; RT1.B; Rmcs1; expressed sequence AI845868; histocompatibility 2, class II antigen A, beta; response to metastatic cancers 1;
General Note Phenotypic Similarity to Human Syndrome: Idiopathic Dilated Cardiomyopathy in double homozygous mice of the strain NOD.Cg-H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell (J:86540)
Molecular Note A neomycin selection cassette was inserted into exon 2. In addition, the ES cell line used was derived from the 129S2/SvPas strain, which carries a deletion in the promoter region of H2-Ea. Consequently, these MHC class II molecule-deficient mice lacked cell surface expression of both class II-A and class II-E MHC proteins. [MGI Ref ID J:74418]
 
Allele Symbol Rag1tm1Mom
Allele Name targeted mutation 1, Peter Mombaerts
Allele Type Targeted (Null/Knockout)
Common Name(s) RAG-1-; RAG1null; Rag-; Rag-1KO; Rag1-; Rag1tm1Mom;
Mutation Made By Peter Mombaerts,   Max Planck Research Unit for Neurogenetics
Strain of Origin129S7/SvEvBrd-Hprt<+>
ES Cell Line NameAB1
ES Cell Line Strain129S7/SvEvBrd-Hprt<+>
Site of Expressionexpression is seen in bone marrow derived cell lines.
Gene Symbol and Name Rag1, recombination activating gene 1
Chromosome 2
Gene Common Name(s) RAG-1; RNF74; Rag-1;
Molecular Note A 1356 bp genomic fragment of the Rag1 gene, encoding the nuclear localization signal and the zinc-finger motif, was replaced by a neomycin cassette. A mutant transcript expressed from this allele was detected by Northern blot in bone marrow derived cell lines from homozygous mice. [MGI Ref ID J:1934] [MGI Ref ID J:96036]
 
Allele Symbol Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell
Allele Name transgene insertion N8, John F Elliott
Allele Type Transgenic (Inserted expressed sequence)
Common Name(s) DQ6 transgene; HLA-DQ6 transgene; Tg(CD4,HLA-DQA1*0102,HLADQB1*0602)1Ell;
Strain of OriginNOD/ShiLtJ
Expressed Gene HLA-DQA1, major histocompatibility complex, class II, DQ alpha 1, human
Expressed Gene CD4, CD4 molecule, human
Expressed Gene HLA-DQB1, major histocompatibility complex, class II, DQ beta 1, human
Promoter HLA-DQB1, major histocompatibility complex, class II, DQ beta 1, human
Promoter HLA-DQA1, major histocompatibility complex, class II, DQ alpha 1, human
Molecular Note The human CD4 gene lacking one exon but including its promoter was fused downstream of a mouse CD4 enhancer element then mixed with a large DNA fragment containing both HLA-DQA*0102 and HLA-DQB*0602 and injected into NOD/LtJ one celled embryos. A singlefounder line is maintained. [MGI Ref ID J:113267]
 
 
 

Genotyping

Genotyping Information

Genotyping Protocols

H2-Ab1tm1Grualternate2, Separated PCR
DQ8 Alpha, QPCR
DQ8 Beta, QPCR
Rag1tm1Mom, High Resolution Melting
Rag1tm1Mom, Standard PCR
Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell, Separated PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Hayward SL; Suzuki K; Elliott JF. 2007. A radioligand binding assay to measure anti-thyroperoxidase autoantibodies in mice. J Immunol Methods 323(2):114-22. [PubMed: 17482640]  [MGI Ref ID J:124227]

Additional References

H2-Ab1tm1Gru related

Adoro S; McCaughtry T; Erman B; Alag A; Van Laethem F; Park JH; Tai X; Kimura M; Wang L; Grinberg A; Kubo M; Bosselut R; Love P; Singer A. 2011. Coreceptor gene imprinting governs thymocyte lineage fate. EMBO J 31(2):366-77. [PubMed: 22036949]  [MGI Ref ID J:180236]

Alsharifi M; Koskinen A; Wijesundara DK; Bettadapura J; Mullbacher A. 2013. MHC class II-alpha chain knockout mice support increased viral replication that is independent of their lack of MHC class II cell surface expression and associated immune function deficiencies. PLoS One 8(6):e68458. [PubMed: 23840854]  [MGI Ref ID J:204317]

Andersen C; Jensen T; Nansen A; Marker O; Thomsen AR. 1999. CD4(+) T cell-mediated protection against a lethal outcome of systemic infection with vesicular stomatitis virus requires CD40 ligand expression, but not IFN-gamma or IL-4. Int Immunol 11(12):2035-42. [PubMed: 10590269]  [MGI Ref ID J:110491]

Anderson BE; Taylor PA; McNiff JM; Jain D; Demetris AJ; Panoskaltsis-Mortari A; Ager A; Blazar BR; Shlomchik WD; Shlomchik MJ. 2008. Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells. Blood 111(10):5242-51. [PubMed: 18285547]  [MGI Ref ID J:135662]

Anderson CC; Mukherjee R; Sinclair NR; Jevnikar AM. 1997. Hypogammaglobulinaemia occurs in Fas-deficient MRL-lpr mice following deletion of MHC class II molecules. Clin Exp Immunol 109(3):473-9. [PubMed: 9328125]  [MGI Ref ID J:42959]

Andreasen SO; Christensen JE; Marker O; Thomsen AR. 2000. Role of CD40 ligand and CD28 in induction and maintenance of antiviral CD8+ effector T cell responses. J Immunol 164(7):3689-97. [PubMed: 10725727]  [MGI Ref ID J:123023]

Archambault AS; Carrero JA; Barnett LG; McGee NG; Sim J; Wright JO; Raabe T; Chen P; Ding H; Allenspach EJ; Dragatsis I; Laufer TM; Wu GF. 2013. Cutting edge: Conditional MHC class II expression reveals a limited role for B cell antigen presentation in primary and secondary CD4 T cell responses. J Immunol 191(2):545-50. [PubMed: 23772037]  [MGI Ref ID J:204951]

Arias DA; McCarty N; Lu L; Maldonado RA; Shinohara ML; Cantor H. 2010. Unexpected role of clathrin adaptor AP-1 in MHC-dependent positive selection of T cells. Proc Natl Acad Sci U S A 107(6):2556-61. [PubMed: 20133794]  [MGI Ref ID J:157540]

Arnett HA; Wang Y; Matsushima GK; Suzuki K; Ting JP. 2003. Functional genomic analysis of remyelination reveals importance of inflammation in oligodendrocyte regeneration. J Neurosci 23(30):9824-32. [PubMed: 14586011]  [MGI Ref ID J:88200]

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Ashour HM; Niederkorn JY. 2006. Peripheral tolerance via the anterior chamber of the eye: role of B cells in MHC class I and II antigen presentation. J Immunol 176(10):5950-7. [PubMed: 16670303]  [MGI Ref ID J:131707]

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Baccala R; Witherden D; Gonzalez-Quintial R; Dummer W; Surh CD; Havran WL; Theofilopoulos AN. 2005. Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors. J Immunol 174(8):4606-12. [PubMed: 15814683]  [MGI Ref ID J:98166]

Bansal-Pakala P; Halteman BS; Cheng MH; Croft M. 2004. Costimulation of CD8 T cell responses by OX40. J Immunol 172(8):4821-5. [PubMed: 15067059]  [MGI Ref ID J:89135]

Barnett LG; Simkins HM; Barnett BE; Korn LL; Johnson AL; Wherry EJ; Wu GF; Laufer TM. 2014. B cell antigen presentation in the initiation of follicular helper T cell and germinal center differentiation. J Immunol 192(8):3607-17. [PubMed: 24646739]  [MGI Ref ID J:209996]

Belz GT; Stevenson PG; Castrucci MR; Altman JD; Doherty PC. 2000. Postexposure vaccination massively increases the prevalence of gamma-herpesvirus-specific CD8+ T cells but confers minimal survival advantage on CD4-deficient mice. Proc Natl Acad Sci U S A 97(6):2725-30. [PubMed: 10694575]  [MGI Ref ID J:76987]

Belz GT; Wodarz D; Diaz G; Nowak MA; Doherty PC. 2002. Compromised Influenza Virus-Specific CD8(+)-T-Cell Memory in CD4(+)-T-Cell-Deficient Mice. J Virol 76(23):12388-93. [PubMed: 12414983]  [MGI Ref ID J:80033]

Benlagha K; Wei DG; Veiga J; Teyton L; Bendelac A. 2005. Characterization of the early stages of thymic NKT cell development. J Exp Med 202(4):485-92. [PubMed: 16087715]  [MGI Ref ID J:100557]

Bertram EM; Tafuri A; Shahinian A; Chan VS; Hunziker L; Recher M; Ohashi PS; Mak TW; Watts TH. 2002. Role of ICOS versus CD28 in antiviral immunity. Eur J Immunol 32(12):3376-85. [PubMed: 12432568]  [MGI Ref ID J:80851]

Bessa J; Jegerlehner A; Hinton HJ; Pumpens P; Saudan P; Schneider P; Bachmann MF. 2009. Alveolar macrophages and lung dendritic cells sense RNA and drive mucosal IgA responses. J Immunol 183(6):3788-99. [PubMed: 19710454]  [MGI Ref ID J:152307]

Beutner U; McLellan B; Kraus E; Huber BT. 1996. Lack of MMTV superantigen presentation in MHC class II-deficient mice. Cell Immunol 168(2):141-7. [PubMed: 8640859]  [MGI Ref ID J:110738]

Bhattacharya D; Rossi DJ; Bryder D; Weissman IL. 2006. Purified hematopoietic stem cell engraftment of rare niches corrects severe lymphoid deficiencies without host conditioning. J Exp Med 203(1):73-85. [PubMed: 16380511]  [MGI Ref ID J:118834]

Blache C; Adriouch S; Calbo S; Drouot L; Dulauroy S; Arnoult C; Le Corre S; Six A; Seman M; Boyer O. 2009. Cutting edge: CD4-independent development of functional FoxP3+ regulatory t cells. J Immunol 183(7):4182-6. [PubMed: 19767568]  [MGI Ref ID J:152754]

Bonasio R; Scimone ML; Schaerli P; Grabie N; Lichtman AH; von Andrian UH. 2006. Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus. Nat Immunol 7(10):1092-100. [PubMed: 16951687]  [MGI Ref ID J:112629]

Borowski AB; Boesteanu AC; Mueller YM; Carafides C; Topham DJ; Altman JD; Jennings SR; Katsikis PD. 2007. Memory CD8+ T cells require CD28 costimulation. J Immunol 179(10):6494-503. [PubMed: 17982038]  [MGI Ref ID J:153868]

Boucheron N; Tschismarov R; Goeschl L; Moser MA; Lagger S; Sakaguchi S; Winter M; Lenz F; Vitko D; Breitwieser FP; Muller L; Hassan H; Bennett KL; Colinge J; Schreiner W; Egawa T; Taniuchi I; Matthias P; Seiser C; Ellmeier W. 2014. CD4(+) T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2. Nat Immunol 15(5):439-48. [PubMed: 24681565]  [MGI Ref ID J:209977]

Bowne WB; Srinivasan R; Wolchok JD; Hawkins WG; Blachere NE; Dyall R; Lewis JJ; Houghton AN. 1999. Coupling and uncoupling of tumor immunity and autoimmunity. J Exp Med 190(11):1717-22. [PubMed: 10587362]  [MGI Ref ID J:115120]

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Broussard C; Fleischecker C; Horai R; Chetana M; Venegas AM; Sharp LL; Hedrick SM; Fowlkes BJ; Schwartzberg PL. 2006. Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk. Immunity 25(1):93-104. [PubMed: 16860760]  [MGI Ref ID J:113409]

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Cady CT; Lahn M; Vollmer M; Tsuji M; Seo SJ; Reardon CL; O'Brien RL; Born WK. 2000. Response of murine gamma delta T cells to the synthetic polypeptide poly-Glu50Tyr50. J Immunol 165(4):1790-8. [PubMed: 10925256]  [MGI Ref ID J:120419]

Calderon B; Carrero JA; Miller MJ; Unanue ER. 2011. Cellular and molecular events in the localization of diabetogenic T cells to islets of Langerhans. Proc Natl Acad Sci U S A 108(4):1561-6. [PubMed: 21220322]  [MGI Ref ID J:168246]

Calderon B; Carrero JA; Miller MJ; Unanue ER. 2011. Entry of diabetogenic T cells into islets induces changes that lead to amplification of the cellular response. Proc Natl Acad Sci U S A 108(4):1567-72. [PubMed: 21220309]  [MGI Ref ID J:168247]

Chakkalath HR; Theodos CM; Markowitz JS; Grusby MJ; Glimcher LH; Titus RG. 1995. Class II major histocompatibility complex-deficient mice initially control an infection with Leishmania major but succumb to the disease. J Infect Dis 171(5):1302-8. [PubMed: 7751707]  [MGI Ref ID J:113036]

Chamoto K; Wakita D; Narita Y; Zhang Y; Noguchi D; Ohnishi H; Iguchi T; Sakai T; Ikeda H; Nishimura T. 2006. An essential role of antigen-presenting cell/T-helper type 1 cell-cell interactions in draining lymph node during complete eradication of class II-negative tumor tissue by T-helper type 1 cell therapy. Cancer Res 66(3):1809-17. [PubMed: 16452242]  [MGI Ref ID J:106666]

Chapes SK; Beharka AA. 1998. Salmonella infections in the absence of the major histocompatibility complex II. J Leukoc Biol 63(3):297-304. [PubMed: 9500516]  [MGI Ref ID J:119805]

Chapes SK; Mosier DA; Wright AD; Hart ML. 2001. MHCII, Tlr4 and Nramp1 genes control host pulmonary resistance against the opportunistic bacterium Pasteurella pneumotropica. J Leukoc Biol 69(3):381-6. [PubMed: 11261784]  [MGI Ref ID J:69552]

Chen W; Bennink JR; Morton PA; Yewdell JW. 2002. Mice deficient in perforin, CD4+ T cells, or CD28-mediated signaling maintain the typical immunodominance hierarchies of CD8+ T-cell responses to influenza virus. J Virol 76(20):10332-7. [PubMed: 12239309]  [MGI Ref ID J:126981]

Chen YT; Kung JT. 2005. CD1d-independent developmental acquisition of prompt IL-4 gene inducibility in thymus CD161(NK1)-CD44lowCD4+CD8- T cells is associated with complementarity determining region 3-diverse and biased Vbeta2/Vbeta7/Vbeta8/Valpha3.2 T cell receptor usage. J Immunol 175(10):6537-50. [PubMed: 16272308]  [MGI Ref ID J:119395]

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Christensen JP; Cardin RD; Branum KC; Doherty PC. 1999. CD4(+) T cell-mediated control of a gamma-herpesvirus in B cell- deficient mice is mediated by IFN-gamma. Proc Natl Acad Sci U S A 96(9):5135-40. [PubMed: 10220431]  [MGI Ref ID J:54884]

Chu KK; Tippayawat P; Walker NJ; Harding SV; Atkins HS; Maillere B; Bancroft GJ; Lertmemongkolchai G; Altmann DM. 2011. CD4+ T-cell immunity to the Burkholderia pseudomallei ABC transporter LolC in melioidosis. Eur J Immunol 41(1):107-15. [PubMed: 21182082]  [MGI Ref ID J:174658]

Clarke RL; Thiemann S; Refaeli Y; Werlen G; Potter TA. 2009. A new function for LAT and CD8 during CD8-mediated apoptosis that is independent of TCR signal transduction. Eur J Immunol 39(6):1619-31. [PubMed: 19449311]  [MGI Ref ID J:149450]

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Coles MC; Raulet DH. 1994. Class I dependence of the development of CD4+ CD8- NK1.1+ thymocytes. J Exp Med 180(1):395-9. [PubMed: 8006596]  [MGI Ref ID J:110734]

Coles MC; Raulet DH. 2000. NK1.1+ T cells in the liver arise in the thymus and are selected by interactions with class I molecules on CD4+CD8+ cells. J Immunol 164(5):2412-8. [PubMed: 10679077]  [MGI Ref ID J:112051]

Covassin L; Jangalwe S; Jouvet N; Laning J; Burzenski L; Shultz LD; Brehm MA. 2013. Human immune system development and survival of NOD-scid IL2rgamma (NSG) mice engrafted with human thymus and autologous hematopoietic stem cells. Clin Exp Immunol :. [PubMed: 23869841]  [MGI Ref ID J:200896]

Covassin L; Laning J; Abdi R; Langevin DL; Phillips NE; Shultz LD; Brehm MA. 2011. Human peripheral blood CD4 T cell-engrafted non-obese diabetic-scid IL2rgamma(null) H2-Ab1 (tm1Gru) Tg (human leucocyte antigen D-related 4) mice: a mouse model of human allogeneic graft-versus-host disease. Clin Exp Immunol 166(2):269-80. [PubMed: 21985373]  [MGI Ref ID J:177904]

Crump AL; Grusby MJ; Glimcher LH; Cantor H. 1993. Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages. Proc Natl Acad Sci U S A 90(22):10739-43. [PubMed: 7902569]  [MGI Ref ID J:111327]

Dave VP; Allman D; Keefe R; Hardy RR; Kappes DJ. 1998. HD mice: a novel mouse mutant with a specific defect in the generation of CD4(+) T cells. Proc Natl Acad Sci U S A 95(14):8187-92. [PubMed: 9653162]  [MGI Ref ID J:48734]

Derrick SC; Evering TH; Sambandamurthy VK; Jalapathy KV; Hsu T; Chen B; Chen M; Russell RG; Junqueira-Kipnis AP; Orme IM; Porcelli SA; Jacobs WR Jr; Morris SL. 2007. Characterization of the protective T-cell response generated in CD4-deficient mice by a live attenuated Mycobacterium tuberculosis vaccine. Immunology 120(2):192-206. [PubMed: 17076705]  [MGI Ref ID J:122314]

Dolfi DV; Duttagupta PA; Boesteanu AC; Mueller YM; Oliai CH; Borowski AB; Katsikis PD. 2011. Dendritic cells and CD28 costimulation are required to sustain virus-specific CD8+ T cell responses during the effector phase in vivo. J Immunol 186(8):4599-608. [PubMed: 21389258]  [MGI Ref ID J:172460]

Drutman SB; Trombetta ES. 2010. Dendritic cells continue to capture and present antigens after maturation in vivo. J Immunol 185(4):2140-6. [PubMed: 20644175]  [MGI Ref ID J:162616]

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Rag1tm1Mom related

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Abramson J; Giraud M; Benoist C; Mathis D. 2010. Aire's partners in the molecular control of immunological tolerance. Cell 140(1):123-35. [PubMed: 20085707]  [MGI Ref ID J:158990]

Afshar-Sterle S; Zotos D; Bernard NJ; Scherger AK; Rodling L; Alsop AE; Walker J; Masson F; Belz GT; Corcoran LM; O'Reilly LA; Strasser A; Smyth MJ; Johnstone R; Tarlinton DM; Nutt SL; Kallies A. 2014. Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas. Nat Med 20(3):283-90. [PubMed: 24487434]  [MGI Ref ID J:208773]

Ahern PP; Schiering C; Buonocore S; McGeachy MJ; Cua DJ; Maloy KJ; Powrie F. 2010. Interleukin-23 drives intestinal inflammation through direct activity on T cells. Immunity 33(2):279-88. [PubMed: 20732640]  [MGI Ref ID J:163906]

Ahn S; Lee G; Yang SJ; Lee D; Lee S; Shin HS; Kim MC; Lee KN; Palmer DC; Theoret MR; Jenkinson EJ; Anderson G; Restifo NP; Kim MG. 2008. TSCOT+ thymic epithelial cell-mediated sensitive CD4 tolerance by direct presentation. PLoS Biol 6(8):e191. [PubMed: 18684012]  [MGI Ref ID J:140121]

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Akkina R; Berges BK; Palmer BE; Remling L; Neff CP; Kuruvilla J; Connick E; Folkvord J; Gagliardi K; Kassu A; Akkina SR. 2011. Humanized Rag1gammac Mice Support Multilineage Hematopoiesis and Are Susceptible to HIV-1 Infection via Systemic and Vaginal Routes. PLoS One 6(6):e20169. [PubMed: 21695116]  [MGI Ref ID J:174292]

Alli R; Nguyen P; Boyd K; Sundberg JP; Geiger TL. 2012. A mouse model of clonal CD8+ T lymphocyte-mediated alopecia areata progressing to alopecia universalis. J Immunol 188(1):477-86. [PubMed: 22116824]  [MGI Ref ID J:180590]

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Anderson MG; Nair KS; Amonoo LA; Mehalow A; Trantow CM; Masli S; John SW. 2008. GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma. BMC Genet 9:30. [PubMed: 18402690]  [MGI Ref ID J:134670]

Ando T; Matsumoto K; Namiranian S; Yamashita H; Glatthorn H; Kimura M; Dolan BR; Lee JJ; Galli SJ; Kawakami Y; Jamora C; Kawakami T. 2013. Mast Cells Are Required for Full Expression of Allergen/SEB-Induced Skin Inflammation. J Invest Dermatol 133(12):2695-705. [PubMed: 23752044]  [MGI Ref ID J:202870]

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Antony PA; Piccirillo CA; Akpinarli A; Finkelstein SE; Speiss PJ; Surman DR; Palmer DC; Chan CC; Klebanoff CA; Overwijk WW; Rosenberg SA; Restifo NP. 2005. CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells. J Immunol 174(5):2591-601. [PubMed: 15728465]  [MGI Ref ID J:129825]

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Backhed F; Ding H; Wang T; Hooper LV; Koh GY; Nagy A; Semenkovich CF; Gordon JI. 2004. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A 101(44):15718-23. [PubMed: 15505215]  [MGI Ref ID J:93455]

Bai F; Town T; Qian F; Wang P; Kamanaka M; Connolly TM; Gate D; Montgomery RR; Flavell RA; Fikrig E. 2009. IL-10 signaling blockade controls murine West Nile virus infection. PLoS Pathog 5(10):e1000610. [PubMed: 19816558]  [MGI Ref ID J:162907]

Baine I; Basu S; Ames R; Sellers RS; Macian F. 2013. Helios induces epigenetic silencing of IL2 gene expression in regulatory T cells. J Immunol 190(3):1008-16. [PubMed: 23275607]  [MGI Ref ID J:193030]

Bajenoff M; Germain RN. 2009. B-cell follicle development remodels the conduit system and allows soluble antigen delivery to follicular dendritic cells. Blood 114(24):4989-97. [PubMed: 19713459]  [MGI Ref ID J:155014]

Bajou K; Peng H; Laug WE; Maillard C; Noel A; Foidart JM; Martial JA; DeClerck YA. 2008. Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis. Cancer Cell 14(4):324-34. [PubMed: 18835034]  [MGI Ref ID J:140088]

Bandeira M; Santos CS; de Azevedo EC; Soares LM; Macedo JO; Marchi S; da Silva CL; Chagas-Junior AD; McBride AJ; McBride FW; Reis MG; Athanazio DA. 2011. Attenuated Nephritis in Inducible Nitric Oxide Synthase Knockout C57BL/6 Mice and Pulmonary Hemorrhage in CB17 SCID and Recombination Activating Gene 1 Knockout C57BL/6 Mice Infected with Leptospira interrogans. Infect Immun 79(7):2936-40. [PubMed: 21576342]  [MGI Ref ID J:173478]

Bankoti R; Gupta K; Levchenko A; Stager S. 2012. Marginal zone B cells regulate antigen-specific T cell responses during infection. J Immunol 188(8):3961-71. [PubMed: 22412197]  [MGI Ref ID J:184071]

Banuelos SJ; Shultz LD; Greiner DL; Burzenski LM; Gott B; Lyons BL; Rossini AA; Appel MC. 2004. Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice. Clin Immunol 112(3):273-83. [PubMed: 15308121]  [MGI Ref ID J:91764]

Barjaktarevic I; Rahman A; Radoja S; Bogunovic B; Vollmer A; Vukmanovic S; Maric M. 2006. Inhibitory role of IFN-gamma-inducible lysosomal thiol reductase in T cell activation. J Immunol 177(7):4369-75. [PubMed: 16982871]  [MGI Ref ID J:139329]

Barker TT; Lee PY; Kelly-Scumpia KM; Weinstein JS; Nacionales DC; Kumagai Y; Akira S; Croker BP; Sobel ES; Reeves WH; Satoh M. 2011. Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane. Lab Invest 91(10):1540-50. [PubMed: 21808234]  [MGI Ref ID J:176270]

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Bartemes KR; Iijima K; Kobayashi T; Kephart GM; McKenzie AN; Kita H. 2012. IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs. J Immunol 188(3):1503-13. [PubMed: 22198948]  [MGI Ref ID J:180763]

Basha G; Omilusik K; Chavez-Steenbock A; Reinicke AT; Lack N; Choi KB; Jefferies WA. 2012. A CD74-dependent MHC class I endolysosomal cross-presentation pathway. Nat Immunol 13(3):237-245. [PubMed: 22306692]  [MGI Ref ID J:181327]

Bassetti MF; White J; Kappler JW; Marrack P. 2009. Transgenic Bcl-3 slows T cell proliferation. Int Immunol 21(4):339-48. [PubMed: 19208752]  [MGI Ref ID J:147105]

Beal AM; Ramos-Hernandez N; Riling CR; Nowelsky EA; Oliver PM. 2011. TGF-beta induces the expression of the adaptor Ndfip1 to silence IL-4 production during iT(reg) cell differentiation. Nat Immunol 13(1):77-85. [PubMed: 22080920]  [MGI Ref ID J:179003]

Beamer CA; Migliaccio CT; Jessop F; Trapkus M; Yuan D; Holian A. 2010. Innate immune processes are sufficient for driving silicosis in mice. J Leukoc Biol 88(3):547-57. [PubMed: 20576854]  [MGI Ref ID J:164920]

Beilke JN; Kuhl NR; Van Kaer L; Gill RG. 2005. NK cells promote islet allograft tolerance via a perforin-dependent mechanism. Nat Med 11(10):1059-65. [PubMed: 16155578]  [MGI Ref ID J:101693]

Belkaid Y; Von Stebut E; Mendez S; Lira R; Caler E; Bertholet S; Udey MC; Sacks D. 2002. CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major. J Immunol 168(8):3992-4000. [PubMed: 11937556]  [MGI Ref ID J:125458]

Ben-Sasson SZ; Hogg A; Hu-Li J; Wingfield P; Chen X; Crank M; Caucheteux S; Ratner-Hurevich M; Berzofsky JA; Nir-Paz R; Paul WE. 2013. IL-1 enhances expansion, effector function, tissue localization, and memory response of antigen-specific CD8 T cells. J Exp Med 210(3):491-502. [PubMed: 23460726]  [MGI Ref ID J:197555]

Benahmed F; Chyou S; Dasoveanu D; Chen J; Kumar V; Iwakura Y; Lu TT. 2014. Multiple CD11c+ cells collaboratively express IL-1beta to modulate stromal vascular endothelial growth factor and lymph node vascular-stromal growth. J Immunol 192(9):4153-63. [PubMed: 24659690]  [MGI Ref ID J:209986]

Bendix I; Pfueller CF; Leuenberger T; Glezeva N; Siffrin V; Muller Y; Prozorovski T; Hansen W; Topphoff US; Loddenkemper C; Zipp F; Waiczies S. 2010. MAPK3 deficiency drives autoimmunity via DC arming. Eur J Immunol 40(5):1486-95. [PubMed: 20186879]  [MGI Ref ID J:160957]

Berger SB; Romero X; Ma C; Wang G; Faubion WA; Liao G; Compeer E; Keszei M; Rameh L; Wang N; Boes M; Regueiro JR; Reinecker HC; Terhorst C. 2010. SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages. Nat Immunol 11(10):920-7. [PubMed: 20818396]  [MGI Ref ID J:164685]

Bergstrom KS; Guttman JA; Rumi M; Ma C; Bouzari S; Khan MA; Gibson DL; Vogl AW; Vallance BA. 2008. Modulation of intestinal goblet cell function during infection by an attaching and effacing bacterial pathogen. Infect Immun 76(2):796-811. [PubMed: 17984203]  [MGI Ref ID J:130255]

Bessler M; Rosti V; Peng Y; Cattoretti G; Notaro R; Ohsako S; Elkon KB; Luzzatto L. 2002. Glycosylphosphatidylinositol-linked proteins are required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development. Eur J Immunol 32(9):2607-16. [PubMed: 12207345]  [MGI Ref ID J:78996]

Bettelli E; Pagany M; Weiner HL; Linington C; Sobel RA; Kuchroo VK. 2003. Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J Exp Med 197(9):1073-81. [PubMed: 12732654]  [MGI Ref ID J:83278]

Bettini ML; Pan F; Bettini M; Finkelstein D; Rehg JE; Floess S; Bell BD; Ziegler SF; Huehn J; Pardoll DM; Vignali DA. 2012. Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency. Immunity 36(5):717-30. [PubMed: 22579476]  [MGI Ref ID J:187320]

Binder GK; Griffin DE. 2001. Interferon-gamma-mediated site-specific clearance of alphavirus from CNS neurons. Science 293(5528):303-6. [PubMed: 11452126]  [MGI Ref ID J:125465]

Binstadt BA; Hebert JL; Ortiz-Lopez A; Bronson R; Benoist C; Mathis D. 2009. The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms. Proc Natl Acad Sci U S A 106(39):16758-63. [PubMed: 19805369]  [MGI Ref ID J:153217]

Bizargity P; Del Rio R; Phillippe M; Teuscher C; Bonney EA. 2009. Resistance to lipopolysaccharide-induced preterm delivery mediated by regulatory T cell function in mice. Biol Reprod 80(5):874-81. [PubMed: 19144956]  [MGI Ref ID J:149636]

Blache CA; Manuel ER; Kaltcheva TI; Wong AN; Ellenhorn JD; Blazar BR; Diamond DJ. 2012. Systemic delivery of Salmonella typhimurium transformed with IDO shRNA enhances intratumoral vector colonization and suppresses tumor growth. Cancer Res 72(24):6447-56. [PubMed: 23090116]  [MGI Ref ID J:193636]

Blanc L; Ciciotte SL; Gwynn B; Hildick-Smith GJ; Pierce EL; Soltis KA; Cooney JD; Paw BH; Peters LL. 2012. Critical function for the Ras-GTPase activating protein RASA3 in vertebrate erythropoiesis and megakaryopoiesis. Proc Natl Acad Sci U S A 109(30):12099-104. [PubMed: 22773809]  [MGI Ref ID J:186485]

Block MS; Mendez-Fernandez YV; Van Keulen VP; Hansen MJ; Allen KS; Taboas AL; Rodriguez M; Pease LR. 2005. Inability of bm14 mice to respond to Theiler's murine encephalomyelitis virus is caused by defective antigen presentation, not repertoire selection. J Immunol 174(5):2756-62. [PubMed: 15728484]  [MGI Ref ID J:97717]

Bonnet MC; Preukschat D; Welz PS; van Loo G; Ermolaeva MA; Bloch W; Haase I; Pasparakis M. 2011. The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation. Immunity 35(4):572-82. [PubMed: 22000287]  [MGI Ref ID J:177639]

Borghesi L; Hsu LY; Miller JP; Anderson M; Herzenberg L; Herzenberg L; Schlissel MS; Allman D; Gerstein RM. 2004. B lineage-specific regulation of V(D)J recombinase activity is established in common lymphoid progenitors. J Exp Med 199(4):491-502. [PubMed: 14769852]  [MGI Ref ID J:119401]

Botelho FM; Gaschler GJ; Kianpour S; Zavitz CC; Trimble NJ; Nikota JK; Bauer CM; Stampfli MR. 2010. Innate immune processes are sufficient for driving cigarette smoke-induced inflammation in mice. Am J Respir Cell Mol Biol 42(4):394-403. [PubMed: 19502389]  [MGI Ref ID J:171489]

Bour-Jordan H; Salomon BL; Thompson HL; Szot GL; Bernhard MR; Bluestone JA. 2004. Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells. J Clin Invest 114(7):979-87. [PubMed: 15467837]  [MGI Ref ID J:93421]

Brady BL; Bassing CH. 2011. Differential regulation of proximal and distal Vbeta segments upstream of a functional VDJbeta1 rearrangement upon beta-selection. J Immunol 187(6):3277-85. [PubMed: 21844384]  [MGI Ref ID J:179246]

Brady BL; Rupp LJ; Bassing CH. 2013. Requirement for dicer in survival of proliferating thymocytes experiencing DNA double-strand breaks. J Immunol 190(7):3256-66. [PubMed: 23427252]  [MGI Ref ID J:194523]

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Yi H; Yu X; Gao P; Wang Y; Baek SH; Chen X; Kim HL; Subjeck JR; Wang XY. 2009. Pattern recognition scavenger receptor SRA/CD204 down-regulates Toll-like receptor 4 signaling-dependent CD8 T-cell activation. Blood 113(23):5819-28. [PubMed: 19349620]  [MGI Ref ID J:149497]

Yi JS; Du M; Zajac AJ. 2009. A vital role for interleukin-21 in the control of a chronic viral infection. Science 324(5934):1572-6. [PubMed: 19443735]  [MGI Ref ID J:150002]

Ying H; Yang L; Qiao G; Li Z; Zhang L; Yin F; Xie D; Zhang J. 2010. Cutting edge: CTLA-4-B7 interaction suppresses Th17 cell differentiation. J Immunol 185(3):1375-8. [PubMed: 20601598]  [MGI Ref ID J:162452]

Yokoyama CC; Loh J; Zhao G; Stappenbeck TS; Wang D; Huang HV; Virgin HW; Thackray LB. 2012. Adaptive immunity restricts replication of novel murine astroviruses. J Virol 86(22):12262-70. [PubMed: 22951832]  [MGI Ref ID J:189022]

Yoshida H; Russell J; Senchenkova EY; Almeida Paula LD; Granger DN. 2010. Interleukin-1beta mediates the extra-intestinal thrombosis associated with experimental colitis. Am J Pathol 177(6):2774-81. [PubMed: 20971730]  [MGI Ref ID J:170780]

Yoshizawa K; Nakajima S; Notake T; Miyagawa S; Hida S; Taki S. 2011. IL-15-high-responder developing NK cells bearing Ly49 receptors in IL-15-/- mice. J Immunol 187(10):5162-9. [PubMed: 21967894]  [MGI Ref ID J:179505]

Yu P; Constien R; Dear N; Katan M; Hanke P; Bunney TD; Kunder S; Quintanilla-Martinez L; Huffstadt U; Schroder A; Jones NP; Peters T; Fuchs H; de Angelis MH; Nehls M; Grosse J; Wabnitz P; Meyer TP; Yasuda K; Schiemann M; Schneider-Fresenius C; Jagla W; Russ A; Popp A; Josephs M; Marquardt A; Laufs J; Schmittwolf C; Wagner H; Pfeffer K; Mudde GC. 2005. Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry. Immunity 22(4):451-65. [PubMed: 15845450]  [MGI Ref ID J:97930]

Yu X; Rollins D; Ruhn KA; Stubblefield JJ; Green CB; Kashiwada M; Rothman PB; Takahashi JS; Hooper LV. 2013. TH17 cell differentiation is regulated by the circadian clock. Science 342(6159):727-30. [PubMed: 24202171]  [MGI Ref ID J:202881]

Yui MA; Feng N; Zhang JA; Liaw CY; Rothenberg EV; Longmate JA. 2013. Loss of T cell progenitor checkpoint control underlies leukemia initiation in rag1-deficient nonobese diabetic mice. J Immunol 190(7):3276-88. [PubMed: 23440410]  [MGI Ref ID J:194740]

Yui MA; Rothenberg EV. 2004. Deranged early T cell development in immunodeficient strains of nonobese diabetic mice. J Immunol 173(9):5381-91. [PubMed: 15494484]  [MGI Ref ID J:132809]

Zanucco E; Gotz R; Potapenko T; Carraretto I; Ceteci S; Ceteci F; Seeger W; Savai R; Rapp UR. 2011. Expression of B-RAF V600E in type II pneumocytes causes abnormalities in alveolar formation, airspace enlargement and tumor formation in mice. PLoS One 6(12):e29093. [PubMed: 22194995]  [MGI Ref ID J:182350]

Zattoni M; Mura ML; Deprez F; Schwendener RA; Engelhardt B; Frei K; Fritschy JM. 2011. Brain infiltration of leukocytes contributes to the pathophysiology of temporal lobe epilepsy. J Neurosci 31(11):4037-50. [PubMed: 21411646]  [MGI Ref ID J:180924]

Zenewicz LA; Yancopoulos GD; Valenzuela DM; Murphy AJ; Stevens S; Flavell RA. 2008. Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity 29(6):947-57. [PubMed: 19100701]  [MGI Ref ID J:142640]

Zeng H; Yang K; Cloer C; Neale G; Vogel P; Chi H. 2013. mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function. Nature 499(7459):485-90. [PubMed: 23812589]  [MGI Ref ID J:204754]

Zhang B; Zhang Y; Niu L; Vella AT; Mittler RS. 2010. Dendritic cells and Stat3 are essential for CD137-induced CD8 T cell activation-induced cell death. J Immunol 184(9):4770-8. [PubMed: 20351189]  [MGI Ref ID J:160463]

Zhang M; Takahashi K; Alicot EM; Vorup-Jensen T; Kessler B; Thiel S; Jensenius JC; Ezekowitz RA; Moore FD; Carroll MC. 2006. Activation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injury. J Immunol 177(7):4727-34. [PubMed: 16982912]  [MGI Ref ID J:139312]

Zhang N; Bevan MJ. 2012. TGF-beta signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation. Nat Immunol 13(7):667-73. [PubMed: 22634866]  [MGI Ref ID J:187653]

Zhang P; Nakatsukasa H; Tu E; Kasagi S; Cui K; Ishikawa M; Konkel JE; Maruyama T; Wei G; Abbatiello B; Wang ZQ; Zhao K; Chen W. 2013. PARP-1 regulates expression of TGF-beta receptors in T cells. Blood 122(13):2224-32. [PubMed: 23940283]  [MGI Ref ID J:202490]

Zhang R; Huynh A; Whitcher G; Chang J; Maltzman JS; Turka LA. 2013. An obligate cell-intrinsic function for CD28 in Tregs. J Clin Invest :. [PubMed: 23281398]  [MGI Ref ID J:194503]

Zhang X; Chen W; De Paiva CS; Volpe EA; Gandhi NB; Farley WJ; Li DQ; Niederkorn JY; Stern ME; Pflugfelder SC. 2011. Desiccating Stress Induces CD4(+) T-Cell-Mediated Sjogren's Syndrome-Like Corneal Epithelial Apoptosis via Activation of the Extrinsic Apoptotic Pathway by Interferon-gamma. Am J Pathol 179(4):1807-14. [PubMed: 21843497]  [MGI Ref ID J:176297]

Zhang Y; Daquinag AC; Amaya-Manzanares F; Sirin O; Tseng C; Kolonin MG. 2012. Stromal progenitor cells from endogenous adipose tissue contribute to pericytes and adipocytes that populate the tumor microenvironment. Cancer Res 72(20):5198-208. [PubMed: 23071132]  [MGI Ref ID J:190900]

Zheng L; Sharma R; Gaskin F; Fu SM; Ju ST. 2007. A novel role of IL-2 in organ-specific autoimmune inflammation beyond regulatory T cell checkpoint: both IL-2 knockout and Fas mutation prolong lifespan of Scurfy mice but by different mechanisms. J Immunol 179(12):8035-41. [PubMed: 18056343]  [MGI Ref ID J:155041]

Zhou J; Chehab R; Tkalcevic J; Naylor MJ; Harris J; Wilson TJ; Tsao S; Tellis I; Zavarsek S; Xu D; Lapinskas EJ; Visvader J; Lindeman GJ; Thomas R; Ormandy CJ; Hertzog PJ; Kola I; Pritchard MA. 2005. Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation. EMBO J 24(3):635-44. [PubMed: 15650748]  [MGI Ref ID J:96237]

Zhou J; Ouyang X; Cui X; Schoeb TR; Smythies LE; Johnson MR; Guay-Woodford LM; Chapman AB; Mrug M. 2010. Renal CD14 expression correlates with the progression of cystic kidney disease. Kidney Int 78(6):550-60. [PubMed: 20555320]  [MGI Ref ID J:184258]

Zhou L; Oh SY; Zhou Y; Yuan B; Wu F; Oh MH; Wang Y; Takemoto C; Van Rooijen N; Zheng T; Zhu Z. 2013. SHP-1 regulation of mast cell function in allergic inflammation and anaphylaxis. PLoS One 8(2):e55763. [PubMed: 23390550]  [MGI Ref ID J:197214]

Zhou XF; Yu J; Chang M; Zhang M; Zhou D; Cammas F; Sun SC. 2012. TRIM28 mediates chromatin modifications at the TCRalpha enhancer and regulates the development of T and natural killer T cells. Proc Natl Acad Sci U S A 109(49):20083-8. [PubMed: 23169648]  [MGI Ref ID J:192327]

Zhu G; Augustine MM; Azuma T; Luo L; Yao S; Anand S; Rietz AC; Huang J; Xu H; Flies AS; Flies SJ; Tamada K; Colonna M; van Deursen JM; Chen L. 2009. B7-H4-deficient mice display augmented neutrophil-mediated innate immunity. Blood 113(8):1759-67. [PubMed: 19109567]  [MGI Ref ID J:145712]

Zhu M; Yang Y; Wang Y; Wang Z; Fu YX. 2011. LIGHT regulates inflamed draining lymph node hypertrophy. J Immunol 186(12):7156-63. [PubMed: 21572030]  [MGI Ref ID J:175482]

Zhu ML; Nagavalli A; Su MA. 2013. Aire deficiency promotes TRP-1-specific immune rejection of melanoma. Cancer Res 73(7):2104-16. [PubMed: 23370329]  [MGI Ref ID J:196876]

Zielinski CE; Jacob SN; Bouzahzah F; Ehrlich BE; Craft J. 2005. Naive CD4+ T cells from lupus-prone Fas-intact MRL mice display TCR-mediated hyperproliferation due to intrinsic threshold defects in activation. J Immunol 174(8):5100-9. [PubMed: 15814741]  [MGI Ref ID J:98149]

Zietara N; Lyszkiewicz M; Puchalka J; Pei G; Gutierrez MG; Lienenklaus S; Hobeika E; Reth M; Martins dos Santos VA; Krueger A; Weiss S. 2013. Immunoglobulins drive terminal maturation of splenic dendritic cells. Proc Natl Acad Sci U S A 110(6):2282-7. [PubMed: 23345431]  [MGI Ref ID J:194334]

Zindl CL; Kim TH; Zeng M; Archambault AS; Grayson MH; Choi K; Schreiber RD; Chaplin DD. 2009. The lymphotoxin LTalpha(1)beta(2) controls postnatal and adult spleen marginal sinus vascular structure and function. Immunity 30(3):408-20. [PubMed: 19303389]  [MGI Ref ID J:147033]

da Silva HB; de Salles EM; Panatieri RH; Boscardin SB; Rodriguez-Malaga SM; Alvarez JM; D'Imperio Lima MR. 2013. IFN-gamma-induced priming maintains long-term strain-transcending immunity against blood-stage Plasmodium chabaudi malaria. J Immunol 191(10):5160-9. [PubMed: 24133169]  [MGI Ref ID J:206324]

de Visser KE; Korets LV; Coussens LM. 2005. De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent. Cancer Cell 7(5):411-23. [PubMed: 15894262]  [MGI Ref ID J:98942]

van Nieuwenhuijze AE; Coghill E; Gray D; Prato S; Metcalf D; Alexander WS; Wicks IP. 2014. Transgenic expression of GM-CSF in T cells causes disseminated histiocytosis. Am J Pathol 184(1):184-99. [PubMed: 24183847]  [MGI Ref ID J:206182]

van der Touw W; Cravedi P; Kwan WH; Paz-Artal E; Merad M; Heeger PS. 2013. Cutting edge: Receptors for C3a and C5a modulate stability of alloantigen-reactive induced regulatory T cells. J Immunol 190(12):5921-5. [PubMed: 23690475]  [MGI Ref ID J:204834]

Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell related

Elliot JF. 2006. Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell-Personal Communication MGI Direct Data Submission :.  [MGI Ref ID J:113509]

Hayward SL; Bautista-Lopez N; Suzuki K; Atrazhev A; Dickie P; Elliott JF. 2006. CD4 T cells play major effector role and CD8 T cells initiating role in spontaneous autoimmune myocarditis of HLA-DQ8 transgenic IAb knockout nonobese diabetic mice. J Immunol 176(12):7715-25. [PubMed: 16751419]  [MGI Ref ID J:113267]

Mangalam A; Luckey D; Basal E; Behrens M; Rodriguez M; David C. 2008. HLA-DQ6 (DQB1*0601)-restricted T cells protect against experimental autoimmune encephalomyelitis in HLA-DR3.DQ6 double-transgenic mice by generating anti-inflammatory IFN-gamma. J Immunol 180(11):7747-56. [PubMed: 18490779]  [MGI Ref ID J:136376]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


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Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

Control Information

  Control
   001976 NOD/ShiLtJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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For Licensing and Use Restrictions view the link(s) below:
- Strain(s) not available to companies or for-profit entities.
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- Use of MICE by companies or for-profit entities requires a license prior to shipping.

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phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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