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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
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Description
Strain Information
Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Hemizygote (Female x Male) 25-APR-08 Species laboratory mouse Generation N10F0 (13-JAN-09) Donating Investigator IMR Colony, The Jackson Laboratory Description
In this transgenic strain, deletion of loxP-flanked genes occurs in all tissues, including germ cells. The cre gene in this strain is under the transcriptional control of a human cytomegalovirus minimal promoter and is likely to be expressed before implantation during early embryogenesis. It also appears that the cre gene is X-linked since transgene transmission through males is restricted to female offspring.In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
Development
The cre gene used in this mutant mouse was modified by adding a nuclear localization signal and the human growth hormone gene providing splicing and polyadenylation signals. A construct containing cre coding sequence under the control of a human cytomegalovirus minimal promoter was introduced to BALB/cJ derived BALB/c-I embryonic stem (ES) cells. The resulting mice were backcrossed to the BALB/c background for 8 generations and then backcrossed to the C57BL/6J background for 10 generations.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Tg(CMV-cre)1Cgn allele
003465 BALB/c-Tg(CMV-cre)1Cgn/J View Strains carrying Tg(CMV-cre)1Cgn (1 strain)
008301 B6.Cg-Tg(CMV-Klc1)90Gsn/J 007237 B6.Cg-Tg(CMV-Serpine1)1Dgi/J 006362 C57BL/6J-Tg(CMV-Cox8a/EYFP)17J/J 008450 FVB-Tg(CAG-luc,-GFP)L2G85Chco/J 006439 FVB-Tg(tetO/CMV-KRAS*G12C)9.1Msmi/J 004375 FVB/N-Tg(tetO-Kras2)12Hev/J 002471 STOCK Tg(hCMV-cre)140Sau/J
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System
Cre Recombinase Expression: Germline/Embryonic Expression
Developmental Biology Research
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis: Cre-lox System
Tissue/Cell Markers: Cre-lox System
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tg(CMV-cre)1Cgn | ||
|---|---|---|---|
| Allele Name | transgene insertion 1, University of Cologne | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | CMV-Cre; CMV:Cre; Cre deleter; TgN(CMV-Cre)#Cgn; deleter; ubi-cre; | ||
| Mutation Made By | Frieder Schwenk, University of Cologne | ||
| Strain of Origin | BALB/cJ | ||
| ES Cell Line Name | BALB/c-I | ||
| ES Cell Line Strain | BALB/cJ | ||
| Site of Expression | widespread expression, including germline | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | CMV, cytomegalovirus, human | ||
| Gene Symbol and Name | Tg(CMV-cre)1Cgn, transgene insertion 1, University of Cologne | ||
| Chromosome | X | ||
| Gene Common Name(s) | CMV-Cre; CMV:Cre; Cre deleter; TgN(CMV-Cre)#Cgn; deleter; ubi-cre; | ||
| Driver Note | CMV | ||
| General Note |
Homozygous transgenic mice are viable and fertile. The transgene appears to be X-linked since transgene transmission through males is restricted to female offspring. In transgenic mice, in conjunction with a transgene carrying a loxP-flanked gene, deletion of the loxP-flanked gene occurs in all tissues including germ cells. | ||
| Molecular Note | This transgene expresses Cre recombinase under the control of a human cytomegalovirus (CMV) promoter, active in most cells and tissues. [MGI Ref ID J:75204] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre Melt Curve Analysis, Melt Curve Analysis
Generic Cre Quantitative PCR, QPCR
Generic Cre, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Schwenk F; Baron U; Rajewsky K. 1995. A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res 23(24):5080-1. [PubMed: 8559668] [MGI Ref ID J:75204]
Additional References
Tg(CMV-cre)1Cgn relatedAbraira VE; Del Rio T; Tucker AF; Slonimsky J; Keirnes HL; Goodrich LV. 2008. Cross-repressive interactions between Lrig3 and netrin 1 shape the architecture of the inner ear. Development 135(24):4091-9. [PubMed: 19004851] [MGI Ref ID J:142510]
Adams DJ; Head GA; Markus MA; Lovicu FJ; van der Weyden L; Kontgen F; Arends MJ; Thiru S; Mayorov DN; Morris BJ. 2006. Renin enhancer is critical for control of renin gene expression and cardiovascular function. J Biol Chem 281(42):31753-61. [PubMed: 16895910] [MGI Ref ID J:117294]
Albertson TM; Ogawa M; Bugni JM; Hays LE; Chen Y; Wang Y; Treuting PM; Heddle JA; Goldsby RE; Preston BD. 2009. DNA polymerase epsilon and delta proofreading suppress discrete mutator and cancer phenotypes in mice. Proc Natl Acad Sci U S A 106(40):17101-4. [PubMed: 19805137] [MGI Ref ID J:153684]
Alpy F; Jivkov I; Sorokin L; Klein A; Arnold C; Huss Y; Kedinger M; Simon-Assmann P; Lefebvre O. 2005. Generation of a conditionally null allele of the laminin alpha1 gene. Genesis 43(2):59-70. [PubMed: 16100707] [MGI Ref ID J:102740]
An W; Han JS; Schrum CM; Maitra A; Koentgen F; Boeke JD. 2008. Conditional activation of a single-copy L1 transgene in mice by Cre. Genesis 46(7):373-83. [PubMed: 18615728] [MGI Ref ID J:138548]
Ansel KM; Pastor WA; Rath N; Lapan AD; Glasmacher E; Wolf C; Smith LC; Papadopoulou N; Lamperti ED; Tahiliani M; Ellwart JW; Shi Y; Kremmer E; Rao A; Heissmeyer V. 2008. Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA processing. Nat Struct Mol Biol 15(5):523-30. [PubMed: 18438418] [MGI Ref ID J:146701]
Araki T; Chan G; Newbigging S; Morikawa L; Bronson RT; Neel BG. 2009. Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation. Proc Natl Acad Sci U S A 106(12):4736-41. [PubMed: 19251646] [MGI Ref ID J:147154]
Audero E; Coppi E; Mlinar B; Rossetti T; Caprioli A; Banchaabouchi MA; Corradetti R; Gross C. 2008. Sporadic autonomic dysregulation and death associated with excessive serotonin autoinhibition. Science 321(5885):130-3. [PubMed: 18599790] [MGI Ref ID J:137439]
Bagheri-Fam S; Sim H; Bernard P; Jayakody I; Taketo MM; Scherer G; Harley VR. 2008. Loss of Fgfr2 leads to partial XY sex reversal. Dev Biol 314(1):71-83. [PubMed: 18155190] [MGI Ref ID J:130928]
Baldock PA; Sainsbury A; Couzens M; Enriquez RF; Thomas GP; Gardiner EM; Herzog H. 2002. Hypothalamic Y2 receptors regulate bone formation. J Clin Invest 109(7):915-21. [PubMed: 11927618] [MGI Ref ID J:97455]
Barriere C; Santamaria D; Cerqueira A; Galan J; Martin A; Ortega S; Malumbres M; Dubus P; Barbacid M. 2007. Mice thrive without Cdk4 and Cdk2 Mol Oncol 1:72-83. [MGI Ref ID J:125217]
Bartoli M; Gicquel E; Barrault L; Soheili T; Malissen M; Malissen B; Vincent-Lacaze N; Perez N; Udd B; Danos O; Richard I. 2008. Mannosidase I inhibition rescues the human alpha-sarcoglycan R77C recurrent mutation. Hum Mol Genet 17(9):1214-21. [PubMed: 18252745] [MGI Ref ID J:133929]
Berger S; Wolfer DP; Selbach O; Alter H; Erdmann G; Reichardt HM; Chepkova AN; Welzl H; Haas HL; Lipp HP; Schutz G. 2006. Loss of the limbic mineralocorticoid receptor impairs behavioral plasticity. Proc Natl Acad Sci U S A 103(1):195-200. [PubMed: 16368758] [MGI Ref ID J:104549]
Bleul CC; Corbeaux T; Reuter A; Fisch P; Monting JS; Boehm T. 2006. Formation of a functional thymus initiated by a postnatal epithelial progenitor cell. Nature 441(7096):992-6. [PubMed: 16791198] [MGI Ref ID J:110046]
Bond CT; Herson PS; Strassmaier T; Hammond R; Stackman R; Maylie J; Adelman JP. 2004. Small conductance Ca2+-activated K+ channel knock-out mice reveal the identity of calcium-dependent afterhyperpolarization currents. J Neurosci 24(23):5301-6. [PubMed: 15190101] [MGI Ref ID J:94941]
Boulet AM; Capecchi MR. 2002. Duplication of the Hoxd11 gene causes alterations in the axial and appendicular skeleton of the mouse. Dev Biol 249(1):96-107. [PubMed: 12217321] [MGI Ref ID J:78766]
Boyle K; Egan P; Rakar S; Willson TA; Wicks IP; Metcalf D; Hilton DJ; Nicola NA; Alexander WS; Roberts AW; Robb L. 2007. The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo. Blood 110(5):1466-74. [PubMed: 17510322] [MGI Ref ID J:145513]
Bradley CK; Takano EA; Gothert JR; Gottgens B; Green AR; Begley CG; van Eekelen JA. 2007. Temporal regulation of Cre-recombinase activity in Scl-positive neurons of the central nervous system. Genesis 45(3):145-51. [PubMed: 17330263] [MGI Ref ID J:121708]
Catela C; Bilbao-Cortes D; Slonimsky E; Kratsios P; Rosenthal N; Te Welscher P. 2009. Multiple congenital malformations of Wolf-Hirschhorn syndrome are recapitulated in Fgfrl1 null mice. Dis Model Mech 2(5-6):283-94. [PubMed: 19383940] [MGI Ref ID J:149673]
Chen H; Zou Z; Sarratt KL; Zhou D; Zhang M; Sebzda E; Hammer DA; Kahn ML. 2006. In vivo beta1 integrin function requires phosphorylation-independent regulation by cytoplasmic tyrosines. Genes Dev 20(8):927-32. [PubMed: 16618804] [MGI Ref ID J:108331]
Chen J; Bush JO; Ovitt CE; Lan Y; Jiang R. 2007. The TGF-beta pseudoreceptor gene Bambi is dispensable for mouse embryonic development and postnatal survival. Genesis 45(8):482-6. [PubMed: 17661381] [MGI Ref ID J:125093]
Clausen BE; Waldburger JM; Schwenk F; Barras E; Mach B; Rajewsky K; Forster I; Reith W. 1998. Residual MHC class II expression on mature dendritic cells and activated B cells in RFX5-deficient mice. Immunity 8(2):143-55. [PubMed: 9491996] [MGI Ref ID J:67941]
Constien R; Forde A; Liliensiek B; Grone HJ; Nawroth P; Hammerling G; Arnold B. 2001. Characterization of a novel EGFP reporter mouse to monitor Cre recombination as demonstrated by a Tie2 Cre mouse line. Genesis 30(1):36-44. [PubMed: 11353516] [MGI Ref ID J:69949]
Conti FJ; Monkley SJ; Wood MR; Critchley DR; Muller U. 2009. Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions. Development 136(21):3597-606. [PubMed: 19793892] [MGI Ref ID J:153959]
Cornish AL; Chong MM; Davey GM; Darwiche R; Nicola NA; Hilton DJ; Kay TW; Starr R; Alexander WS. 2003. Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other gamma c-dependent cytokines in peripheral T cells. J Biol Chem 278(25):22755-61. [PubMed: 12665516] [MGI Ref ID J:124411]
Cushman LJ; Burrows HL; Seasholtz AF; Lewandoski M; Muzyczka N; Camper SA. 2000. Cre-mediated recombination in the pituitary gland Genesis 28(3-4):167-74. [PubMed: 11105060] [MGI Ref ID J:66897]
Dakic A; Metcalf D; Di Rago L; Mifsud S; Wu L; Nutt SL. 2005. PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis. J Exp Med 201(9):1487-502. [PubMed: 15867096] [MGI Ref ID J:98188]
Dang MT; Yokoi F; McNaught KS; Jengelley TA; Jackson T; Li J; Li Y. 2005. Generation and characterization of Dyt1 DeltaGAG knock-in mouse as a model for early-onset dystonia. Exp Neurol 196(2):452-63. [PubMed: 16242683] [MGI Ref ID J:104513]
Danilczyk U; Sarao R; Remy C; Benabbas C; Stange G; Richter A; Arya S; Pospisilik JA; Singer D; Camargo SM; Makrides V; Ramadan T; Verrey F; Wagner CA; Penninger JM. 2006. Essential role for collectrin in renal amino acid transport. Nature 444(7122):1088-91. [PubMed: 17167413] [MGI Ref ID J:117490]
Davey RA; Turner AG; McManus JF; Chiu WS; Tjahyono F; Moore AJ; Atkins GJ; Anderson PH; Ma C; Glatt V; MacLean HE; Vincent C; Bouxsein M; Morris HA; Findlay DM; Zajac JD. 2008. Calcitonin receptor plays a physiological role to protect against hypercalcemia in mice. J Bone Miner Res 23(8):1182-93. [PubMed: 18627265] [MGI Ref ID J:150982]
De Gasperi R; Rocher AB; Sosa MA; Wearne SL; Perez GM; Friedrich VL Jr; Hof PR; Elder GA. 2008. The IRG mouse: a two-color fluorescent reporter for assessing Cre-mediated recombination and imaging complex cellular relationships in situ. Genesis 46(6):308-17. [PubMed: 18543298] [MGI Ref ID J:137251]
De Langhe SP; Carraro G; Tefft D; Li C; Xu X; Chai Y; Minoo P; Hajihosseini MK; Drouin J; Kaartinen V; Bellusci S. 2008. Formation and Differentiation of Multiple Mesenchymal Lineages during Lung Development Is Regulated by beta-catenin Signaling. PLoS ONE 3(1):e1516. [PubMed: 18231602] [MGI Ref ID J:131535]
De Langhe SP; Carraro G; Warburton D; Hajihosseini MK; Bellusci S. 2006. Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung. Dev Biol 299(1):52-62. [PubMed: 16989802] [MGI Ref ID J:114396]
Dixon CI; Rosahl TW; Stephens DN. 2008. Targeted deletion of the GABRA2 gene encoding alpha2-subunits of GABA(A) receptors facilitates performance of a conditioned emotional response, and abolishes anxiolytic effects of benzodiazepines and barbiturates. Pharmacol Biochem Behav 90(1):1-8. [PubMed: 18313124] [MGI Ref ID J:140077]
Dours-Zimmermann MT; Maurer K; Rauch U; Stoffel W; Fassler R; Zimmermann DR. 2009. Versican V2 assembles the extracellular matrix surrounding the nodes of ranvier in the CNS. J Neurosci 29(24):7731-42. [PubMed: 19535585] [MGI Ref ID J:150124]
Doyonnas R; LaBarge MA; Sacco A; Charlton C; Blau HM. 2004. Hematopoietic contribution to skeletal muscle regeneration by myelomonocytic precursors. Proc Natl Acad Sci U S A 101(37):13507-12. [PubMed: 15353585] [MGI Ref ID J:92609]
Dufner A; Duncan GS; Wakeham A; Elford AR; Hall HT; Ohashi PS; Mak TW. 2008. CARD6 is interferon inducible but not involved in nucleotide-binding oligomerization domain protein signaling leading to NF-kappaB activation. Mol Cell Biol 28(5):1541-52. [PubMed: 18160713] [MGI Ref ID J:132634]
Eckardt D; Theis M; Doring B; Speidel D; Willecke K; Ott T. 2004. Spontaneous ectopic recombination in cell-type-specific Cre mice removes loxP-flanked marker cassettes in vivo. Genesis 38(4):159-65. [PubMed: 15083516] [MGI Ref ID J:90577]
Epp N; Furstenberger G; Muller K; de Juanes S; Leitges M; Hausser I; Thieme F; Liebisch G; Schmitz G; Krieg P. 2007. 12R-lipoxygenase deficiency disrupts epidermal barrier function. J Cell Biol 177(1):173-82. [PubMed: 17403930] [MGI Ref ID J:134709]
Ermolaeva MA; Michallet MC; Papadopoulou N; Utermohlen O; Kranidioti K; Kollias G; Tschopp J; Pasparakis M. 2008. Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses. Nat Immunol 9(9):1037-46. [PubMed: 18641654] [MGI Ref ID J:139030]
Esposito G; Vitale AM; Leijten FP; Strik AM; Koonen-Reemst AM; Yurttas P; Robben TJ; Coonrod S; Gossen JA. 2007. Peptidylarginine deiminase (PAD) 6 is essential for oocyte cytoskeletal sheet formation and female fertility. Mol Cell Endocrinol 273(1-2):25-31. [PubMed: 17587491] [MGI Ref ID J:138684]
Faust N; Varas F; Kelly LM; Heck S; Graf T. 2000. Insertion of enhanced green fluorescent protein into the lysozyme gene creates mice with green fluorescent granulocytes and macrophages. Blood 96(2):719-26. [PubMed: 10887140] [MGI Ref ID J:63254]
Ferri AL; Cavallaro M; Braida D; Di Cristofano A; Canta A; Vezzani A; Ottolenghi S; Pandolfi PP; Sala M; DeBiasi S; Nicolis SK. 2004. Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain. Development 131(15):3805-19. [PubMed: 15240551] [MGI Ref ID J:92063]
Foukas LC; Claret M; Pearce W; Okkenhaug K; Meek S; Peskett E; Sancho S; Smith AJ; Withers DJ; Vanhaesebroeck B. 2006. Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation. Nature 441(7091):366-70. [PubMed: 16625210] [MGI Ref ID J:109024]
Frommer F; Heinen TJ; Wunderlich FT; Yogev N; Buch T; Roers A; Bettelli E; Muller W; Anderton SM; Waisman A. 2008. Tolerance without clonal expansion: self-antigen-expressing B cells program self-reactive T cells for future deletion. J Immunol 181(8):5748-59. [PubMed: 18832734] [MGI Ref ID J:140751]
Fu X; Kiyama T; Li R; Russell M; Klein WH; Mu X. 2009. Epitope-tagging Math5 and Pou4f2: New tools to study retinal ganglion cell development in the mouse. Dev Dyn 238(9):2309-2317. [PubMed: 19459208] [MGI Ref ID J:151244]
Gangloff YG; Mueller M; Dann SG; Svoboda P; Sticker M; Spetz JF; Um SH; Brown EJ; Cereghini S; Thomas G; Kozma SC. 2004. Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Mol Cell Biol 24(21):9508-16. [PubMed: 15485918] [MGI Ref ID J:94133]
Garbi N; Tanaka S; Momburg F; Hammerling GJ. 2006. Impaired assembly of the major histocompatibility complex class I peptide-loading complex in mice deficient in the oxidoreductase ERp57. Nat Immunol 7(1):93-102. [PubMed: 16311600] [MGI Ref ID J:112606]
Garci-Higuera I; Manchado E; Dubus P; Canamero M; Mendez J; Moreno S; Malumbres M. 2008. Genomic stability and tumour suppression by the APC/C cofactor Cdh1. Nat Cell Biol 10(7):802-11. [PubMed: 18552834] [MGI Ref ID J:137456]
Garcia-Lavandeira M; Quereda V; Flores I; Saez C; Diaz-Rodriguez E; Japon MA; Ryan AK; Blasco MA; Dieguez C; Malumbres M; Alvarez CV. 2009. A GRFa2/Prop1/stem (GPS) cell niche in the pituitary. PLoS ONE 4(3):e4815. [PubMed: 19283075] [MGI Ref ID J:147363]
Genetic Resource Sciences at The Jackson Laboratory. 2008. Expression/Specificity patterns of Cre transgenes MGI Direct Data Submission :. [MGI Ref ID J:137887]
Gilfillan S; Ho EL; Cella M; Yokoyama WM; Colonna M. 2002. NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. Nat Immunol 3(12):1150-5. [PubMed: 12426564] [MGI Ref ID J:80426]
Goldman DC; Hackenmiller R; Nakayama T; Sopory S; Wong C; Kulessa H; Christian JL. 2006. Mutation of an upstream cleavage site in the BMP4 prodomain leads to tissue-specific loss of activity. Development 133(10):1933-42. [PubMed: 16624858] [MGI Ref ID J:108516]
Graf C; Niwa S; Muller M; Kinzel B; Bornancin F. 2008. Wild-type levels of ceramide and ceramide-1-phosphate in the retina of ceramide kinase-like-deficient mice. Biochem Biophys Res Commun 373(1):159-63. [PubMed: 18555012] [MGI Ref ID J:137892]
Grier JD; Xiong S; Elizondo-Fraire AC; Parant JM; Lozano G. 2006. Tissue-Specific Differences of p53 Inhibition by Mdm2 and Mdm4. Mol Cell Biol 26(1):192-8. [PubMed: 16354690] [MGI Ref ID J:104114]
Grossmann KS; Wende H; Paul FE; Cheret C; Garratt AN; Zurborg S; Feinberg K; Besser D; Schulz H; Peles E; Selbach M; Birchmeier W; Birchmeier C. 2009. The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development. Proc Natl Acad Sci U S A 106(39):16704-9. [PubMed: 19805360] [MGI Ref ID J:153219]
Gu C; Rodriguez ER; Reimert DV; Shu T; Fritzsch B; Richards LJ; Kolodkin AL; Ginty DD. 2003. Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development. Dev Cell 5(1):45-57. [PubMed: 12852851] [MGI Ref ID J:93799]
Guerra C; Mijimolle N; Dhawahir A; Dubus P; Barradas M; Serrano M; Campuzano V; Barbacid M. 2003. Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context. Cancer Cell 4(2):111-20. [PubMed: 12957286] [MGI Ref ID J:86101]
Guimera J; Weisenhorn DV; Wurst W. 2006. Megane/Heslike is required for normal GABAergic differentiation in the mouse superior colliculus. Development 133(19):3847-57. [PubMed: 16968817] [MGI Ref ID J:119562]
Guo N; Hawkins C; Nathans J. 2004. Frizzled6 controls hair patterning in mice. Proc Natl Acad Sci U S A 101(25):9277-81. [PubMed: 15169958] [MGI Ref ID J:91412]
Gurniak CB; Perlas E; Witke W. 2005. The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration. Dev Biol 278(1):231-41. [PubMed: 15649475] [MGI Ref ID J:96452]
Hambsch B; Grinevich V; Seeburg PH; Schwarz MK. 2005. {gamma}-Protocadherins, presenilin-mediated release of C-terminal fragment promotes locus expression. J Biol Chem 280(16):15888-97. [PubMed: 15711011] [MGI Ref ID J:98737]
Hammond RS; Bond CT; Strassmaier T; Ngo-Anh TJ; Adelman JP; Maylie J; Stackman RW. 2006. Small-conductance Ca2+-activated K+ channel type 2 (SK2) modulates hippocampal learning, memory, and synaptic plasticity. J Neurosci 26(6):1844-53. [PubMed: 16467533] [MGI Ref ID J:105645]
Hart AH; Hartley L; Sourris K; Stadler ES; Li R; Stanley EG; Tam PP; Elefanty AG; Robb L. 2002. Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo. Development 129(15):3597-608. [PubMed: 12117810] [MGI Ref ID J:77443]
Hartenstein B; Dittrich BT; Stickens D; Heyer B; Vu TH; Teurich S; Schorpp-Kistner M; Werb Z; Angel P. 2006. Epidermal development and wound healing in matrix metalloproteinase 13-deficient mice. J Invest Dermatol 126(2):486-96. [PubMed: 16374453] [MGI Ref ID J:104953]
Harzheim D; Pfeiffer KH; Fabritz L; Kremmer E; Buch T; Waisman A; Kirchhof P; Kaupp UB; Seifert R. 2008. Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP. EMBO J 27(4):692-703. [PubMed: 18219271] [MGI Ref ID J:131820]
Herrmann T; Muckenthaler M; van der Hoeven F; Brennan K; Gehrke SG; Hubert N; Sergi C; Grone HJ; Kaiser I; Gosch I; Volkmann M; Riedel HD; Hentze MW; Stewart AF; Stremmel W. 2004. Iron overload in adult Hfe-deficient mice independent of changes in the steady-state expression of the duodenal iron transporters DMT1 and Ireg1/ferroportin. J Mol Med 82(1):39-48. [PubMed: 14618243] [MGI Ref ID J:132141]
Herrmann T; van der Hoeven F; Grone HJ; Stewart AF; Langbein L; Kaiser I; Liebisch G; Gosch I; Buchkremer F; Drobnik W; Schmitz G; Stremmel W. 2003. Mice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathy. J Cell Biol 161(6):1105-15. [PubMed: 12821645] [MGI Ref ID J:84096]
High FA; Lu MM; Pear WS; Loomes KM; Kaestner KH; Epstein JA. 2008. Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development. Proc Natl Acad Sci U S A 105(6):1955-9. [PubMed: 18245384] [MGI Ref ID J:143962]
Hori K; Cholewa-Waclaw J; Nakada Y; Glasgow SM; Masui T; Henke RM; Wildner H; Martarelli B; Beres TM; Epstein JA; Magnuson MA; Macdonald RJ; Birchmeier C; Johnson JE. 2008. A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling. Genes Dev 22(2):166-78. [PubMed: 18198335] [MGI Ref ID J:130251]
Howell OW; Scharfman HE; Herzog H; Sundstrom LE; Beck-Sickinger A; Gray WP. 2003. Neuropeptide Y is neuroproliferative for post-natal hippocampal precursor cells. J Neurochem 86(3):646-59. [PubMed: 12859678] [MGI Ref ID J:92582]
Hu X; Bulger M; Roach JN; Eszterhas SK; Olivier E; Bouhassira EE; Groudine MT; Fiering S. 2003. Promoters of the murine embryonic beta-like globin genes Ey and betah1 do not compete for interaction with the beta-globin locus control region. Proc Natl Acad Sci U S A 100(3):1111-5. [PubMed: 12525692] [MGI Ref ID J:82296]
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Schmidt-Ullrich R; Aebischer T; Hulsken J; Birchmeier W; Klemm U; Scheidereit C. 2001. Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices. Development 128(19):3843-53. [PubMed: 11585809] [MGI Ref ID J:71744]
Schwab KR; Patterson LT; Hartman HA; Song N; Lang RA; Lin X; Potter SS. 2007. Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development. BMC Biol 5:15. [PubMed: 17425782] [MGI Ref ID J:121918]
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Seiler A; Schneider M; Forster H; Roth S; Wirth EK; Culmsee C; Plesnila N; Kremmer E; Radmark O; Wurst W; Bornkamm GW; Schweizer U; Conrad M. 2008. Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab 8(3):237-48. [PubMed: 18762024] [MGI Ref ID J:139668]
Sekyere EO; Dunn LL; Rahmanto YS; Richardson DR. 2006. Role of melanotransferrin in iron metabolism: studies using targeted gene disruption in vivo. Blood 107(7):2599-601. [PubMed: 16291590] [MGI Ref ID J:115256]
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Stanley EG; Biben C; Allison J; Hartley L; Wicks IP; Campbell IK; McKinley M; Barnett L; Koentgen F; Robb L; Harvey RP. 2000. Targeted insertion of a lacZ reporter gene into the mouse Cer1 locus reveals complex and dynamic expression during embryogenesis [letter] Genesis 26(4):259-64. [PubMed: 10748464] [MGI Ref ID J:62081]
Stanton H; Rogerson FM; East CJ; Golub SB; Lawlor KE; Meeker CT; Little CB; Last K; Farmer PJ; Campbell IK; Fourie AM; Fosang AJ. 2005. ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature 434(7033):648-52. [PubMed: 15800625] [MGI Ref ID J:105138]
Starr R; Fuchsberger M; Lau LS; Uldrich AP; Goradia A; Willson TA; Verhagen AM; Alexander WS; Smyth MJ. 2009. SOCS-1 binding to tyrosine 441 of IFN-gamma receptor subunit 1 contributes to the attenuation of IFN-gamma signaling in vivo. J Immunol 183(7):4537-44. [PubMed: 19734231] [MGI Ref ID J:152785]
Steinbrecher KA; Wowk SA; Rudolph JA; Witte DP; Cohen MB. 2002. Targeted inactivation of the mouse guanylin gene results in altered dynamics of colonic epithelial proliferation. Am J Pathol 161(6):2169-78. [PubMed: 12466132] [MGI Ref ID J:80545]
Stemmler MP; Hecht A; Kemler R. 2005. E-cadherin intron 2 contains cis-regulatory elements essential for gene expression. Development 132(5):965-76. [PubMed: 15673570] [MGI Ref ID J:96963]
Stennard FA; Costa MW; Lai D; Biben C; Furtado MB; Solloway MJ; McCulley DJ; Leimena C; Preis JI; Dunwoodie SL; Elliott DE; Prall OW; Black BL; Fatkin D; Harvey RP. 2005. Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation. Development 132(10):2451-62. [PubMed: 15843414] [MGI Ref ID J:98489]
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Sugiyama F; Churchill GA; Higgins DC; Johns C; Makaritsis KP; Gavras H; Paigen B. 2001. Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci. Genomics 71(1):70-7. [PubMed: 11161799] [MGI Ref ID J:66987]
Suire S; Condliffe AM; Ferguson GJ; Ellson CD; Guillou H; Davidson K; Welch H; Coadwell J; Turner M; Chilvers ER; Hawkins PT; Stephens L. 2006. Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils. Nat Cell Biol 8(11):1303-9. [PubMed: 17041586] [MGI Ref ID J:147259]
Sur C; Wafford KA; Reynolds DS; Hadingham KL; Bromidge F; Macaulay A; Collinson N; O'Meara G; Howell O; Newman R; Myers J; Atack JR; Dawson GR; McKernan RM; Whiting PJ; Rosahl TW. 2001. Loss of the major GABA(A) receptor subtype in the brain is not lethal in mice. J Neurosci 21(10):3409-18. [PubMed: 11331371] [MGI Ref ID J:69290]
Tan HO; Reid CA; Single FN; Davies PJ; Chiu C; Murphy S; Clarke AL; Dibbens L; Krestel H; Mulley JC; Jones MV; Seeburg PH; Sakmann B; Berkovic SF; Sprengel R; Petrou S. 2007. Reduced cortical inhibition in a mouse model of familial childhood absence epilepsy. Proc Natl Acad Sci U S A 104(44):17536-41. [PubMed: 17947380] [MGI Ref ID J:127120]
Tasan RO; Lin S; Hetzenauer A; Singewald N; Herzog H; Sperk G. 2009. Increased novelty-induced motor activity and reduced depression-like behavior in neuropeptide Y (NPY)-Y4 receptor knockout mice. Neuroscience 158(4):1717-30. [PubMed: 19121371] [MGI Ref ID J:148974]
Theis M; de Wit C; Schlaeger TM; Eckardt D; Kruger O; Doring B; Risau W; Deutsch U; Pohl U; Willecke K. 2001. Endothelium-specific replacement of the connexin43 coding region by a lacZ reporter gene. Genesis 29(1):1-13. [PubMed: 11135457] [MGI Ref ID J:78662]
Thien CB; Scaife RM; Papadimitriou JM; Murphy MA; Bowtell DD; Langdon WY. 2003. A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase. J Exp Med 197(4):503-13. [PubMed: 12591907] [MGI Ref ID J:81965]
Thomas T; Dixon MP; Kueh AJ; Voss AK. 2008. Mof (MYST1 or KAT8) is essential for progression of embryonic development past the blastocyst stage and required for normal chromatin architecture. Mol Cell Biol 28(16):5093-105. [PubMed: 18541669] [MGI Ref ID J:139761]
Tomasello E; Desmoulins PO; Chemin K; Guia S; Cremer H; Ortaldo J; Love P; Kaiserlian D; Vivier E. 2000. Combined natural killer cell and dendritic cell functional deficiency in KARAP/DAP12 loss-of-function mutant mice. Immunity 13(3):355-64. [PubMed: 11021533] [MGI Ref ID J:64764]
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Tuzi NL; Clarke AR; Bradford B; Aitchison L; Thomson V; Manson JC. 2004. Cre-loxP mediated control of PrP to study transmissible spongiform encephalopathy diseases. Genesis 40(1):1-6. [PubMed: 15354287] [MGI Ref ID J:92302]
Tvrdik P; Capecchi MR. 2006. Reversal of Hox1 gene subfunctionalization in the mouse. Dev Cell 11(2):239-50. [PubMed: 16890163] [MGI Ref ID J:119279]
Tzima S; Victoratos P; Kranidioti K; Alexiou M; Kollias G. 2009. Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production. J Exp Med 206(5):1167-79. [PubMed: 19398754] [MGI Ref ID J:148498]
Ueki Y; Lin CY; Senoo M; Ebihara T; Agata N; Onji M; Saheki Y; Kawai T; Mukherjee PM; Reichenberger E; Olsen BR. 2007. Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 'cherubism' mice. Cell 128(1):71-83. [PubMed: 17218256] [MGI Ref ID J:117880]
Uemura T; Sato T; Aoki T; Yamamoto A; Okada T; Hirai R; Harada R; Mori K; Tagaya M; Harada A. 2009. p31 deficiency influences endoplasmic reticulum tubular morphology and cell survival. Mol Cell Biol 29(7):1869-81. [PubMed: 19188447] [MGI Ref ID J:147771]
Varinou L; Ramsauer K; Karaghiosoff M; Kolbe T; Pfeffer K; Muller M; Decker T. 2003. Phosphorylation of the Stat1 transactivation domain is required for full-fledged IFN-gamma-dependent innate immunity. Immunity 19(6):793-802. [PubMed: 14670297] [MGI Ref ID J:130622]
Vennekens R; Olausson J; Meissner M; Bloch W; Mathar I; Philipp SE; Schmitz F; Weissgerber P; Nilius B; Flockerzi V; Freichel M. 2007. Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4. Nat Immunol 8(3):312-320. [PubMed: 17293867] [MGI Ref ID J:118679]
Volna P; Lebduska P; Draberova L; Simova S; Heneberg P; Boubelik M; Bugajev V; Malissen B; Wilson BS; Horejsi V; Malissen M; Draber P. 2004. Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL. J Exp Med 200(8):1001-13. [PubMed: 15477348] [MGI Ref ID J:93950]
Vooijs M; Ong CT; Hadland B; Huppert S; Liu Z; Korving J; van den Born M; Stappenbeck T; Wu Y; Clevers H; Kopan R. 2007. Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE. Development 134(3):535-44. [PubMed: 17215306] [MGI Ref ID J:119910]
Waisman A; Kraus M; Seagal J; Ghosh S; Melamed D; Song J; Sasaki Y; Classen S; Lutz C; Brombacher F; Nitschke L; Rajewsky K. 2007. IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Ig alpha/beta. J Exp Med 204(4):747-58. [PubMed: 17420268] [MGI Ref ID J:125719]
Walters KA; Allan CM; Jimenez M; Lim PR; Davey RA; Zajac JD; Illingworth P; Handelsman DJ. 2007. Female mice haploinsufficient for an inactivated androgen receptor (AR) exhibit age-dependent defects that resemble the AR null phenotype of dysfunctional late follicle development, ovulation, and fertility. Endocrinology 148(8):3674-84. [PubMed: 17463055] [MGI Ref ID J:129631]
Wang CC; Shi H; Guo K; Ng CP; Li J; Gan BQ; Chien Liew H; Leinonen J; Rajaniemi H; Zhou ZH; Zeng Q; Hong W. 2007. VAMP8/endobrevin as a general vesicular SNARE for regulated exocytosis of the exocrine system. Mol Biol Cell 18(3):1056-63. [PubMed: 17215514] [MGI Ref ID J:123895]
Wang P; Bowl MR; Bender S; Peng J; Farber L; Chen J; Ali A; Zhang Z; Alberts AS; Thakker RV; Shilatifard A; Williams BO; Teh BT. 2008. Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice. Mol Cell Biol 28(9):2930-40. [PubMed: 18212049] [MGI Ref ID J:135255]
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Health & husbandry
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Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, these mice are bred as homozygotes. The cre transgene appears to be X-linked since transgene transmission through males is restricted to female offspring. Mating System Homozygote x Hemizygote (Female x Male) 25-APR-08 Diet Information LabDiet® 5K52/5K67
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Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $209.90 Male Hemizygous for Tg(CMV-cre)1Cgn $209.90 Female Homozygous for Tg(CMV-cre)1Cgn
Pairs /Price (US dollars $) Pair Genotype $419.80 Homozygous for Tg(CMV-cre)1Cgn x Hemizygous for Tg(CMV-cre)1Cgn
Additional Supply Details
| Pricing for International shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $272.90 Male Hemizygous for Tg(CMV-cre)1Cgn $272.90 Female Homozygous for Tg(CMV-cre)1Cgn
Pairs /Price (US dollars $) Pair Genotype $545.80 Homozygous for Tg(CMV-cre)1Cgn x Hemizygous for Tg(CMV-cre)1Cgn
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
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Control Information
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| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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