Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote         (Female x Male)   14-NOV-06 Species laboratory mouse Generation N12+F15 (22-FEB-11) Generation Definitions   Donating Investigator Menno de Winther,   Maastricht University

Description
Homozygotes are viable and fertile. Liver sections treated with antibodies against type I and type II macrophage scavenger class A receptors show no protein staining. Homozygous mice have less severe lesion development in Apoe-deficient atherosclerosis model. Peritoneal macrophages have reduced mLDL uptake in vitro. Homozygous mice have increased susceptibility to pathogens. These mice may be useful in studies of immunity and host defense, cholesterol transport in macrophages, macrophage-derived foam cells, and atherosclerosis.

Development
A pGK1neo cassette replaces alpha-helical coiled coil sequence of exon 4 (essential for the formation of functional trimeric receptors) of the endogenous gene. The construct was electroporated into “A3-1” embryonic stem (ES) cells of “129 origin.” Correctly targeted ES cells were injected into C57BL/6J blastocysts and transplanted into the uteri of ICR females. The resulting chimeric males were backcrossed to ICR females and heterozygous mice were bred to generate homozygous mice. During or near 1998, Dr. Hiroshi Suzuki and Dr. Tatsuhiko Kodama sent these mutant mice to Dr. Menno de Winther at Maastricht University in The Netherlands. There, mutant mice were backcrossed to C57BL/6JIco for 12 generations before arriving at The Jackson Laboratory.

Control Information

	Control
	000664 C57BL/6J
Considerations for Choosing Controls

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI

- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested. Barrett Esophagus   (MSR1) Prostate Cancer   (MSR1)

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI

      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.

Msr1^tm1Csk/Msr1^tm1Csk

        involves: 129X1/SvJ * ICR

• mortality/aging
• increased susceptibility to bacterial infection induced morbidity/mortality
  • decreased survival after infection with Listeria monocytogenes   (MGI Ref ID J:39079)
• increased susceptibility to viral infection induced morbidity/mortality
  • decreased survival after infection with herpes simplex virus, HSV-1   (MGI Ref ID J:39079)
• immune system phenotype
• increased interleukin-12 secretion
  • mutants produce higher levels of Il-12 in vivo in response to CpG oligodeoxynucleotide administration compared to wild-type mice   (MGI Ref ID J:110433)
• increased susceptibility to bacterial infection induced morbidity/mortality
  • decreased survival after infection with Listeria monocytogenes   (MGI Ref ID J:39079)
• increased susceptibility to viral infection induced morbidity/mortality
  • decreased survival after infection with herpes simplex virus, HSV-1   (MGI Ref ID J:39079)

Msr1^tm1Csk/Msr1^tm1Csk

        involves: 129S7/SvEvBrd * C57BL/6J

• immune system phenotype
• abnormal macrophage physiology
  • macrophage uptake and degradation of acetylated low density lipoproteins involved in the development of atherosclerosis   (MGI Ref ID J:91911)

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research
Inflammation

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol		Msr1tm1Csk
Allele Name		targeted mutation 1, Chugai Pharmaceutical Co, Ltd
Allele Type		Targeted (knock-out)
Common Name(s)		MSR-; Msr1-KO; Msr1tm1Kod; SR-; SR-A-; SR-AI/II KO; SRAKO; SRKO; Scvrtm1; Sra-;
Mutation Made By		Menno de Winther,   Maastricht University
Strain of Origin		129X1/SvJ
ES Cell Line Name		A3-1
ES Cell Line Strain		129X1/SvJ
Gene Symbol and Name		Msr1, macrophage scavenger receptor 1
Chromosome		8
Gene Common Name(s)		CD204; MRS-A; MSR-A; RGD1564316; SCARA1; SR-A; SR-AI; SR-AII; SRA; Scvr; phSR1; phSR2; scavenger receptor;
Molecular Note		A neomycin cassette was inserted into the EcoRI site in exon 4, which encodes the alpha helical coiled-coil structure essential for the formation of functional trimeric receptors. Protein was not detectable by immunostaining of liver sections from homozygous mutant animals. [MGI Ref ID J:39079]

Genotyping

Genotyping Information

Genotyping Protocols

Msr1^tm1Csk, Standard PCR
Msr1^tm1Csk_MCA, Melt Curve Analysis

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Msr1^tm1Csk related

Amiel E; Acker JL; Collins RM; Berwin B. 2009. Uncoupling scavenger receptor A-mediated phagocytosis of bacteria from endotoxic shock resistance. Infect Immun 77(10):4567-73. [PubMed: 19667044]  [MGI Ref ID J:153370]

Amiel E; Alonso A; Uematsu S; Akira S; Poynter ME; Berwin B. 2009. Pivotal Advance: Toll-like receptor regulation of scavenger receptor-A-mediated phagocytosis. J Leukoc Biol 85(4):595-605. [PubMed: 19112093]  [MGI Ref ID J:146918]

Areschoug T; Waldemarsson J; Gordon S. 2008. Evasion of macrophage scavenger receptor A-mediated recognition by pathogenic streptococci. Eur J Immunol 38(11):3068-79. [PubMed: 18924218]  [MGI Ref ID J:143268]

Arredouani MS; Franco F; Imrich A; Fedulov A; Lu X; Perkins D; Soininen R; Tryggvason K; Shapiro SD; Kobzik L. 2007. Scavenger Receptors SR-AI/II and MARCO limit pulmonary dendritic cell migration and allergic airway inflammation. J Immunol 178(9):5912-20. [PubMed: 17442975]  [MGI Ref ID J:145827]

Arredouani MS; Yang Z; Imrich A; Ning Y; Qin G; Kobzik L. 2006. The macrophage scavenger receptor SR-AI/II and lung defense against pneumococci and particles. Am J Respir Cell Mol Biol 35(4):474-8. [PubMed: 16675784]  [MGI Ref ID J:126897]

Beamer CA; Holian A. 2005. Scavenger receptor class A type I/II (CD204) null mice fail to develop fibrosis following silica exposure. Am J Physiol Lung Cell Mol Physiol 289(2):L186-95. [PubMed: 15849212]  [MGI Ref ID J:104753]

Beamer CA; Holian A. 2008. Silica suppresses Toll-like receptor ligand-induced dendritic cell activation. FASEB J 22(6):2053-63. [PubMed: 18180331]  [MGI Ref ID J:136538]

Becker M; Cotena A; Gordon S; Platt N. 2006. Expression of the class A macrophage scavenger receptor on specific subpopulations of murine dendritic cells limits their endotoxin response. Eur J Immunol 36(4):950-60. [PubMed: 16552714]  [MGI Ref ID J:114785]

Bowdish DM; Sakamoto K; Kim MJ; Kroos M; Mukhopadhyay S; Leifer CA; Tryggvason K; Gordon S; Russell DG. 2009. MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosis. PLoS Pathog 5(6):e1000474. [PubMed: 19521507]  [MGI Ref ID J:162913]

Boyanovsky BB; van der Westhuyzen DR; Webb NR. 2005. Group V secretory phospholipase A2-modified low density lipoprotein promotes foam cell formation by a SR-A- and CD36-independent process that involves cellular proteoglycans. J Biol Chem 280(38):32746-52. [PubMed: 16040605]  [MGI Ref ID J:102157]

Brown JM; Swindle EJ; Kushnir-Sukhov NM; Holian A; Metcalfe DD. 2007. Silica-directed mast cell activation is enhanced by scavenger receptors. Am J Respir Cell Mol Biol 36(1):43-52. [PubMed: 16902192]  [MGI Ref ID J:130522]

Chen Y; Pikkarainen T; Elomaa O; Soininen R; Kodama T; Kraal G; Tryggvason K. 2005. Defective microarchitecture of the spleen marginal zone and impaired response to a thymus-independent type 2 antigen in mice lacking scavenger receptors MARCO and SR-A. J Immunol 175(12):8173-80. [PubMed: 16339556]  [MGI Ref ID J:122271]

Chen Y; Sullivan C; Peng C; Shan Y; Hu Y; Li D; Li S. 2011. A tumor suppressor function of the Msr1 gene in leukemia stem cells of chronic myeloid leukemia. Blood 118(2):390-400. [PubMed: 21596859]  [MGI Ref ID J:174876]

Chen Y; Wermeling F; Sundqvist J; Jonsson AB; Tryggvason K; Pikkarainen T; Karlsson MC. 2010. A regulatory role for macrophage class A scavenger receptors in TLR4-mediated LPS responses. Eur J Immunol 40(5):1451-60. [PubMed: 20162551]  [MGI Ref ID J:160959]

Cohen G; Makranz C; Spira M; Kodama T; Reichert F; Rotshenker S. 2006. Non-PKC DAG/phorbol-ester receptor(s) inhibit complement receptor-3 and nPKC inhibit scavenger receptor-AI/II-mediated myelin phagocytosis but cPKC, PI3k, and PLCgamma activate myelin phagocytosis by both. Glia 53(5):538-50. [PubMed: 16374778]  [MGI Ref ID J:156136]

Cotena A; Gordon S; Platt N. 2004. The class A macrophage scavenger receptor attenuates CXC chemokine production and the early infiltration of neutrophils in sterile peritonitis. J Immunol 173(10):6427-32. [PubMed: 15528383]  [MGI Ref ID J:94284]

Court N; Vasseur V; Vacher R; Fremond C; Shebzukhov Y; Yeremeev VV; Maillet I; Nedospasov SA; Gordon S; Fallon PG; Suzuki H; Ryffel B; Quesniaux VF. 2010. Partial redundancy of the pattern recognition receptors, scavenger receptors, and C-type lectins for the long-term control of Mycobacterium tuberculosis infection. J Immunol 184(12):7057-70. [PubMed: 20488784]  [MGI Ref ID J:161134]

Dahl M; Bauer AK; Arredouani M; Soininen R; Tryggvason K; Kleeberger SR; Kobzik L. 2007. Protection against inhaled oxidants through scavenging of oxidized lipids by macrophage receptors MARCO and SR-AI/II. J Clin Invest 117(3):757-64. [PubMed: 17332894]  [MGI Ref ID J:120724]

Devries-Seimon T; Li Y; Yao PM; Stone E; Wang Y; Davis RJ; Flavell R; Tabas I. 2005. Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor. J Cell Biol 171(1):61-73. [PubMed: 16203857]  [MGI Ref ID J:102612]

Eto M; Yoshikawa H; Fujimura H; Naba I; Sumi-Akamaru H; Takayasu S; Itabe H; Sakoda S. 2003. The role of CD36 in peripheral nerve remyelination after crush injury. Eur J Neurosci 17(12):2659-66. [PubMed: 12823473]  [MGI Ref ID J:89664]

Facciponte JG; Wang XY; Subjeck JR. 2007. Hsp110 and Grp170, members of the Hsp70 superfamily, bind to scavenger receptor-A and scavenger receptor expressed by endothelial cells-I. Eur J Immunol 37(8):2268-79. [PubMed: 17615582]  [MGI Ref ID J:123549]

Freigang S; Landais E; Zadorozhny V; Kain L; Yoshida K; Liu Y; Deng S; Palinski W; Savage PB; Bendelac A; Teyton L. 2012. Scavenger receptors target glycolipids for natural killer T cell activation. J Clin Invest 122(11):3943-54. [PubMed: 23064364]  [MGI Ref ID J:193547]

Fukuhara-Takaki K; Sakai M; Sakamoto Y; Takeya M; Horiuchi S. 2005. Expression of class A scavenger receptor is enhanced by high glucose in vitro and under diabetic conditions in vivo: one mechanism for an increased rate of atherosclerosis in diabetes. J Biol Chem 280(5):3355-64. [PubMed: 15556945]  [MGI Ref ID J:96978]

Fulton WB; Reeves RH; Takeya M; De Maio A. 2006. A quantitative trait loci analysis to map genes involved in lipopolysaccharide-induced inflammatory response: identification of macrophage scavenger receptor 1 as a candidate gene. J Immunol 176(6):3767-73. [PubMed: 16517746]  [MGI Ref ID J:129535]

Geier H; Celli J. 2011. Phagocytic Receptors Dictate Phagosomal Escape and Intracellular Proliferation of Francisella tularensis. Infect Immun 79(6):2204-14. [PubMed: 21422184]  [MGI Ref ID J:171926]

Hagiwara SI; Takeya M; Suzuki H; Kodama T; van der Laan LJ; Kraal G ; Kitamura N ; Takahashi K. 1999. Role of macrophage scavenger receptors in hepatic granuloma formation in mice. Am J Pathol 154(3):705-20. [PubMed: 10079248]  [MGI Ref ID J:53369]

Hamilton RF Jr; Thakur SA; Mayfair JK; Holian A. 2006. MARCO mediates silica uptake and toxicity in alveolar macrophages from C57BL/6 mice. J Biol Chem 281(45):34218-26. [PubMed: 16984918]  [MGI Ref ID J:117252]

Haworth R; Platt N; Keshav S; Hughes D; Darley E; Suzuki H; Kurihara Y; Kodama T; Gordon S. 1997. The macrophage scavenger receptor type A is expressed by activated macrophages and protects the host against lethal endotoxic shock. J Exp Med 186(9):1431-9. [PubMed: 9348300]  [MGI Ref ID J:112082]

Helming L; Gordon S. 2007. Macrophage fusion induced by IL-4 alternative activation is a multistage process involving multiple target molecules. Eur J Immunol 37(1):33-42. [PubMed: 17154265]  [MGI Ref ID J:117069]

Hollifield M; Bou Ghanem E; de Villiers WJ; Garvy BA. 2007. Scavenger receptor A dampens induction of inflammation in response to the fungal pathogen Pneumocystis carinii. Infect Immun 75(8):3999-4005. [PubMed: 17548480]  [MGI Ref ID J:123372]

Huang F; Buttini M; Wyss-Coray T; McConlogue L; Kodama T; Pitas RE; Mucke L. 1999. Elimination of the class A scavenger receptor does not affect amyloid plaque formation or neurodegeneration in transgenic mice expressing human amyloid protein precursors. Am J Pathol 155(5):1741-7. [PubMed: 10550330]  [MGI Ref ID J:58338]

Inoue M; Xuan X; Fujisaki K; Igarashi I; Suzuki H. 2006. Short report: role of type I/II scavenger receptors in malarial infection in C57BL/6J mice. Am J Trop Med Hyg 75(1):178-81. [PubMed: 16837728]  [MGI Ref ID J:135702]

Ishiguro T; Naito M; Yamamoto T; Hasegawa G; Gejyo F; Mitsuyama M; Suzuki H; Kodama T. 2001. Role of macrophage scavenger receptors in response to Listeria monocytogenes infection in mice. Am J Pathol 158(1):179-88. [PubMed: 11141491]  [MGI Ref ID J:68438]

Jozefowski S; Arredouani M; Sulahian T; Kobzik L. 2005. Disparate regulation and function of the class A scavenger receptors SR-AI/II and MARCO. J Immunol 175(12):8032-41. [PubMed: 16339540]  [MGI Ref ID J:122238]

Jozefowski S; Sulahian TH; Arredouani M; Kobzik L. 2006. Role of scavenger receptor MARCO in macrophage responses to CpG oligodeoxynucleotides. J Leukoc Biol 80(4):870-9. [PubMed: 16882874]  [MGI Ref ID J:113090]

Kabamoto S; Bhagat NA; Suzuki H; You M; Kamio T; Tsuji N; Claveria FG; Nagasawa H; Igarashi I; Toyoda Y; Fujisaki K. 2002. Comparison of macrophage scavenger receptor-A knockout mice with wild type ones in the immune response against repeated infestation with Haemaphysalis longicornis. J Vet Med Sci 64(4):355-9. [PubMed: 12014582]  [MGI Ref ID J:127030]

Kamada N; Kodama T; Suzuki H. 2001. Macrophage scavenger receptor (SR-A I/II) deficiency reduced diet-induced atherosclerosis in C57BL/6J mice. J Atheroscler Thromb 8(1):1-6. [PubMed: 11686309]  [MGI Ref ID J:117403]

Kobayashi H; Sakashita N; Okuma T; Terasaki Y; Tsujita K; Suzuki H; Kodama T; Nomori H; Kawasuji M; Takeya M. 2007. Class A scavenger receptor (CD204) attenuates hyperoxia-induced lung injury by reducing oxidative stress. J Pathol 212(1):38-46. [PubMed: 17370294]  [MGI Ref ID J:122097]

Kobayashi Y; Miyaji C; Watanabe H; Umezu H; Hasegawa G; Abo T; Arakawa M; Kamata N; Suzuki H; Kodama T; Naito M. 2000. Role of macrophage scavenger receptor in endotoxin shock J Pathol 192(2):263-72. [PubMed: 11004705]  [MGI Ref ID J:65024]

Komohara Y; Terasaki Y; Kaikita K; Suzuki H; Kodama T; Takeya M. 2005. Clearance of apoptotic cells is not impaired in mouse embryos deficient in class A scavenger receptor types I and II (CD204). Dev Dyn 232(1):67-74. [PubMed: 15580571]  [MGI Ref ID J:95137]

Korporaal SJ; Van Eck M; Adelmeijer J; Ijsseldijk M; Out R; Lisman T; Lenting PJ; Van Berkel TJ; Akkerman JW. 2007. Platelet activation by oxidized low density lipoprotein is mediated by CD36 and scavenger receptor-A. Arterioscler Thromb Vasc Biol 27(11):2476-83. [PubMed: 17761940]  [MGI Ref ID J:135004]

Kunjathoor VV; Febbraio M; Podrez EA; Moore KJ; Andersson L; Koehn S; Rhee JS; Silverstein R; Hoff HF; Freeman MW. 2002. Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages. J Biol Chem 277(51):49982-8. [PubMed: 12376530]  [MGI Ref ID J:80905]

Li S; Sun Y; Liang CP; Thorp EB; Han S; Jehle AW; Saraswathi V; Pridgen B; Kanter JE; Li R; Welch CL; Hasty AH; Bornfeldt KE; Breslow JL; Tabas I; Tall AR. 2009. Defective phagocytosis of apoptotic cells by macrophages in atherosclerotic lesions of ob/ob mice and reversal by a fish oil diet. Circ Res 105(11):1072-82. [PubMed: 19834009]  [MGI Ref ID J:170144]

Lin YL; de Villiers WJ; Garvy B; Post SR; Nagy TR; Safadi FF; Faugere MC; Wang G; Malluche HH; Williams JP. 2007. The effect of class a scavenger receptor deficiency in bone. J Biol Chem 282(7):4653-60. [PubMed: 17166840]  [MGI Ref ID J:120924]

Ling W; Lougheed M; Suzuki H; Buchan A; Kodama T; Steinbrecher UP. 1997. Oxidized or acetylated low density lipoproteins are rapidly cleared by the liver in mice with disruption of the scavenger receptor class A type I/II gene. J Clin Invest 100(2):244-52. [PubMed: 9218499]  [MGI Ref ID J:41808]

Manning-Tobin JJ; Moore KJ; Seimon TA; Bell SA; Sharuk M; Alvarez-Leite JI; de Winther MP; Tabas I; Freeman MW. 2009. Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice. Arterioscler Thromb Vasc Biol 29(1):19-26. [PubMed: 18948635]  [MGI Ref ID J:159787]

Matsumoto K; Sano H; Nagai R; Suzuki H; Kodama T; Yoshida M; Ueda S; Smedsrod B; Horiuchi S. 2000. Endocytic uptake of advanced glycation end products by mouse liver sinusoidal endothelial cells is mediated by a scavenger receptor distinct from the macrophage scavenger receptor class A. Biochem J 352 Pt 1:233-40. [PubMed: 11062078]  [MGI Ref ID J:114182]

Moore KJ; Kunjathoor VV; Koehn SL; Manning JJ; Tseng AA; Silver JM; McKee M; Freeman MW. 2005. Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice. J Clin Invest 115(8):2192-201. [PubMed: 16075060]  [MGI Ref ID J:100226]

Mukhopadhyay S; Chen Y; Sankala M; Peiser L; Pikkarainen T; Kraal G; Tryggvason K; Gordon S. 2006. MARCO, an innate activation marker of macrophages, is a class A scavenger receptor for Neisseria meningitidis. Eur J Immunol 36(4):940-9. [PubMed: 16525990]  [MGI Ref ID J:114824]

Mukhopadhyay S; Varin A; Chen Y; Liu B; Tryggvason K; Gordon S. 2011. SR-A/MARCO-mediated ligand delivery enhances intracellular TLR and NLR function, but ligand scavenging from cell surface limits TLR4 response to pathogens. Blood 117(4):1319-28. [PubMed: 21098741]  [MGI Ref ID J:168587]

Naba I; Yoshikawa H; Sakoda S; Itabe H; Suzuki H; Kodama T; Yanagihara T. 2000. Onion-bulb formation after a single compression injury in the macrophage scavenger receptor knockout mice Exp Neurol 166(1):83-9. [PubMed: 11031085]  [MGI Ref ID J:65692]

Naba I; Yoshikawa H; Sakoda S; Itabe H; Suzuki H; Kodama T; Yanagihara T. 2000. Successful generation of peripheral neuropathy with onion-bulb formation in the macrophage scavenger receptor classA knockout mouse treated with isoniazid. Neurosci Lett 290(1):5-8. [PubMed: 10925161]  [MGI Ref ID J:107986]

Neyen C; Pluddemann A; Mukhopadhyay S; Maniati E; Bossard M; Gordon S; Hagemann T. 2013. Macrophage scavenger receptor a promotes tumor progression in murine models of ovarian and pancreatic cancer. J Immunol 190(7):3798-805. [PubMed: 23447685]  [MGI Ref ID J:194838]

Nicoletti A; Caligiuri G; Tornberg I; Kodama T; Stemme S; Hansson GK. 1999. The macrophage scavenger receptor type A directs modified proteins to antigen presentation. Eur J Immunol 29(2):512-21. [PubMed: 10064066]  [MGI Ref ID J:115253]

Ohnishi K; Komohara Y; Fujiwara Y; Takemura K; Lei X; Nakagawa T; Sakashita N; Takeya M. 2011. Suppression of TLR4-mediated inflammatory response by macrophage class A scavenger receptor (CD204). Biochem Biophys Res Commun 411(3):516-22. [PubMed: 21756882]  [MGI Ref ID J:175685]

Ono K; Nishitani C; Mitsuzawa H; Shimizu T; Sano H; Suzuki H; Kodama T; Fujii N; Fukase K; Hirata K; Kuroki Y. 2006. Mannose-binding lectin augments the uptake of lipid A, Staphylococcus aureus, and Escherichia coli by Kupffer cells through increased cell surface expression of scavenger receptor A. J Immunol 177(8):5517-23. [PubMed: 17015738]  [MGI Ref ID J:139434]

Palecanda A; Paulauskis J; Al-Mutairi E; Imrich A; Qin G; Suzuki H; Kodama T; Tryggvason K; Koziel H; Kobzik L. 1999. Role of the scavenger receptor MARCO in alveolar macrophage binding of unopsonized environmental particles. J Exp Med 189(9):1497-506. [PubMed: 10224290]  [MGI Ref ID J:110931]

Platt N; Suzuki H; Kodama T; Gordon S. 2000. Apoptotic thymocyte clearance in scavenger receptor class A-deficient mice is apparently normal. J Immunol 164(9):4861-7. [PubMed: 10779795]  [MGI Ref ID J:124530]

Pluddemann A; Hoe JC; Makepeace K; Moxon ER; Gordon S. 2009. The macrophage scavenger receptor A is host-protective in experimental meningococcal septicaemia. PLoS Pathog 5(2):e1000297. [PubMed: 19214213]  [MGI Ref ID J:162700]

Qian J; Yi H; Guo C; Yu X; Zuo D; Chen X; Kane JM 3rd; Repasky EA; Subjeck JR; Wang XY. 2011. CD204 suppresses large heat shock protein-facilitated priming of tumor antigen gp100-specific T cells and chaperone vaccine activity against mouse melanoma. J Immunol 187(6):2905-14. [PubMed: 21832164]  [MGI Ref ID J:179257]

Rahaman SO; Lennon DJ; Febbraio M; Podrez EA; Hazen SL; Silverstein RL. 2006. A CD36-dependent signaling cascade is necessary for macrophage foam cell formation. Cell Metab 4(3):211-21. [PubMed: 16950138]  [MGI Ref ID J:129743]

Raycroft MT; Harvey BP; Bruck MJ; Mamula MJ. 2012. Inhibition of antigen trafficking through scavenger receptor A. J Biol Chem 287(8):5310-6. [PubMed: 22215667]  [MGI Ref ID J:182435]

Rotshenker S; Reichert F; Gitik M; Haklai R; Elad-Sfadia G; Kloog Y. 2008. Galectin-3/MAC-2, Ras and PI3K activate complement receptor-3 and scavenger receptor-AI/II mediated myelin phagocytosis in microglia. Glia 56(15):1607-13. [PubMed: 18615637]  [MGI Ref ID J:156259]

Seimon TA; Nadolski MJ; Liao X; Magallon J; Nguyen M; Feric NT; Koschinsky ML; Harkewicz R; Witztum JL; Tsimikas S; Golenbock D; Moore KJ; Tabas I. 2010. Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress. Cell Metab 12(5):467-82. [PubMed: 21035758]  [MGI Ref ID J:167910]

Seimon TA; Obstfeld A; Moore KJ; Golenbock DT; Tabas I. 2006. Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages. Proc Natl Acad Sci U S A 103(52):19794-9. [PubMed: 17167049]  [MGI Ref ID J:118240]

Shi S; Blumenthal A; Hickey CM; Gandotra S; Levy D; Ehrt S. 2005. Expression of many immunologically important genes in Mycobacterium tuberculosis-infected macrophages is independent of both TLR2 and TLR4 but dependent on IFN-alphabeta receptor and STAT1. J Immunol 175(5):3318-28. [PubMed: 16116224]  [MGI Ref ID J:113220]

Suzuki H; Kurihara Y; Takeya M; Kamada N; Kataoka M; Jishage K ; Ueda O ; Sakaguchi H ; Higashi T ; Suzuki T ; Takashima Y ; Kawabe Y ; Cynshi O ; Wada Y ; Honda M ; Kurihara H ; Aburatani H ; Doi T ; Matsumoto A ; Azuma S ; Noda T ; Toyoda Y ; Itakura H; Yazaki Y ; Kodama T ; et al. 1997. A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature 386(6622):292-6. [PubMed: 9069289]  [MGI Ref ID J:39079]

Takakura Y; Takagi T; Hashiguchi M; Nisihikawa M; Yamashita F; Doi T; Imanishi T; Suzuki H; Kodama T; Hashida M. 1999. Characterization of plasmid DNA binding and uptake by peritoneal macrophages from class a scavenger receptor knockout mice. Pharm Res 16(4):503-8. [PubMed: 10227703]  [MGI Ref ID J:54878]

Takemura K; Sakashita N; Fujiwara Y; Komohara Y; Lei X; Ohnishi K; Suzuki H; Kodama T; Mizuta H; Takeya M. 2010. Class A scavenger receptor promotes osteoclast differentiation via the enhanced expression of receptor activator of NF-kappaB (RANK). Biochem Biophys Res Commun 391(4):1675-80. [PubMed: 20036645]  [MGI Ref ID J:157090]

Tamura Y; Osuga J; Adachi H; Tozawa R; Takanezawa Y; Ohashi K; Yahagi N; Sekiya M; Okazaki H; Tomita S; Iizuka Y; Koizumi H; Inaba T; Yagyu H; Kamada N; Suzuki H; Shimano H; Kadowaki T; Tsujimoto M; Arai H; Yamada N; Ishibashi S. 2004. Scavenger receptor expressed by endothelial cells I (SREC-I) mediates the uptake of acetylated low density lipoproteins by macrophages stimulated with lipopolysaccharide. J Biol Chem 279(30):30938-44. [PubMed: 15145948]  [MGI Ref ID J:91911]

Terpstra V; van Berkel TJ. 2000. Scavenger receptors on liver Kupffer cells mediate the in vivo uptake of oxidatively damaged red blood cells in mice. Blood 95(6):2157-63. [PubMed: 10706889]  [MGI Ref ID J:110359]

Tewalt EF; Maynard JC; Walters JJ; Schell AM; Berwin BL; Nicchitta CV; Norbury CC. 2008. Redundancy renders the glycoprotein 96 receptor scavenger receptor A dispensable for cross priming in vivo. Immunology 125(4):480-91. [PubMed: 18489571]  [MGI Ref ID J:144444]

Thelen T; Hao Y; Medeiros AI; Curtis JL; Serezani CH; Kobzik L; Harris LH; Aronoff DM. 2010. The class A scavenger receptor, macrophage receptor with collagenous structure, is the major phagocytic receptor for Clostridium sordellii expressed by human decidual macrophages. J Immunol 185(7):4328-35. [PubMed: 20810988]  [MGI Ref ID J:164310]

Thomas CA; Li Y; Kodama T; Suzuki H; Silverstein SC; El Khoury J. 2000. Protection from lethal gram-positive infection by macrophage scavenger receptor-dependent phagocytosis. J Exp Med 191(1):147-56. [PubMed: 10620613]  [MGI Ref ID J:59246]

Todt JC; Hu B; Curtis JL. 2008. The scavenger receptor SR-A I/II (CD204) signals via the receptor tyrosine kinase Mertk during apoptotic cell uptake by murine macrophages. J Leukoc Biol 84(2):510-8. [PubMed: 18511575]  [MGI Ref ID J:138416]

Tsujita K; Kaikita K; Hayasaki T; Honda T; Kobayashi H; Sakashita N; Suzuki H; Kodama T; Ogawa H; Takeya M. 2007. Targeted deletion of class A macrophage scavenger receptor increases the risk of cardiac rupture after experimental myocardial infarction. Circulation 115(14):1904-11. [PubMed: 17389263]  [MGI Ref ID J:135372]

Tyurin VA; Cao W; Tyurina YY; Gabrilovich DI; Kagan VE. 2011. Mass-spectrometric characterization of peroxidized and hydrolyzed lipids in plasma and dendritic cells of tumor-bearing animals. Biochem Biophys Res Commun 413(1):149-53. [PubMed: 21872574]  [MGI Ref ID J:177532]

Usui HK; Shikata K; Sasaki M; Okada S; Matsuda M; Shikata Y; Ogawa D; Kido Y; Nagase R; Yozai K; Ohga S; Tone A; Wada J; Takeya M; Horiuchi S; Kodama T; Makino H. 2007. Macrophage scavenger receptor-a-deficient mice are resistant against diabetic nephropathy through amelioration of microinflammation. Diabetes 56(2):363-72. [PubMed: 17259380]  [MGI Ref ID J:121943]

Van Berkel TJ; Van Velzen A; Kruijt JK; Suzuki H; Kodama T. 1998. Uptake and catabolism of modified LDL in scavenger-receptor class A type I/II knock-out mice. Biochem J 331(Pt 1):29-35. [PubMed: 9512458]  [MGI Ref ID J:114274]

Varin A; Mukhopadhyay S; Herbein G; Gordon S. 2010. Alternative activation of macrophages by IL-4 impairs phagocytosis of pathogens but potentiates microbial-induced signalling and cytokine secretion. Blood 115(2):353-62. [PubMed: 19880493]  [MGI Ref ID J:156317]

Wang MD; Kiss RS; Franklin V; McBride HM; Whitman SC; Marcel YL. 2007. Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathways. J Lipid Res 48(3):633-45. [PubMed: 17148552]  [MGI Ref ID J:120283]

Wang XY; Facciponte J; Chen X; Subjeck JR; Repasky EA. 2007. Scavenger receptor-A negatively regulates antitumor immunity. Cancer Res 67(10):4996-5002. [PubMed: 17510431]  [MGI Ref ID J:121736]

Wermeling F; Chen Y; Pikkarainen T; Scheynius A; Winqvist O; Izui S; Ravetch JV; Tryggvason K; Karlsson MC. 2007. Class A scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupus. J Exp Med 204(10):2259-65. [PubMed: 17893199]  [MGI Ref ID J:126041]

Xu Y; Qian L; Zong G; Ma K; Zhu X; Zhang H; Li N; Yang Q; Bai H; Ben J; Li X; Xu Y; Chen Q. 2012. Class A scavenger receptor promotes cerebral ischemic injury by pivoting microglia/macrophage polarization. Neuroscience 218:35-48. [PubMed: 22652221]  [MGI Ref ID J:192417]

Yi H; Guo C; Yu X; Gao P; Qian J; Zuo D; Manjili MH; Fisher PB; Subjeck JR; Wang XY. 2011. Targeting the Immunoregulator SRA/CD204 Potentiates Specific Dendritic Cell Vaccine-Induced T-cell Response and Antitumor Immunity. Cancer Res 71(21):6611-20. [PubMed: 21914786]  [MGI Ref ID J:177377]

Yi H; Yu X; Gao P; Wang Y; Baek SH; Chen X; Kim HL; Subjeck JR; Wang XY. 2009. Pattern recognition scavenger receptor SRA/CD204 down-regulates Toll-like receptor 4 signaling-dependent CD8 T-cell activation. Blood 113(23):5819-28. [PubMed: 19349620]  [MGI Ref ID J:149497]

Yu H; Ha T; Liu L; Wang X; Gao M; Kelley J; Kao R; Williams D; Li C. 2012. Scavenger receptor A (SR-A) is required for LPS-induced TLR4 mediated NF-kappaB activation in macrophages. Biochim Biophys Acta 1823(7):1192-8. [PubMed: 22627090]  [MGI Ref ID J:185204]

Zhu FG; Reich CF; Pisetsky DS. 2001. The role of the macrophage scavenger receptor in immune stimulation by bacterial DNA and synthetic oligonucleotides. Immunology 103(2):226-34. [PubMed: 11412310]  [MGI Ref ID J:110433]

de Winther MP; Gijbels MJ; van Dijk KW; van Gorp PJ; suzuki H; Kodama T; Frants RR; Havekes LM; Hofker MH. 1999. Scavenger receptor deficiency leads to more complex atherosclerotic lesions in APOE3Leiden transgenic mice. Atherosclerosis 144(2):315-21. [PubMed: 10407492]  [MGI Ref ID J:56239]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX11

Colony Maintenance

Breeding & Husbandry	When maintaining a live colony, these mice are maintained as homozygotes.
Mating System	Homozygote x Homozygote         (Female x Male)   14-NOV-06
Diet Information	LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Control Information

	Control
	000664 C57BL/6J
Considerations for Choosing Controls
Control Pricing Information for Genetically Engineered Mutant Strains.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

---

Ordering Information
JAX^® Mice
Surgical and Preconditioning Services
JAX^® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use

General Terms and Conditions

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:	207-288-6470
fax:	207-288-6655

JAX^® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.