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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Congenic; Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered Mutant Mice. Mating System Heterozygote x Homozygote (Female x Male) Species laboratory mouse Generation N8F9 (07-DEC-07) Development
The Jackson shaker 2 Jackson re-mutation (js-2J) arose spontaneously in the strain B6.Cg-T2J +/+ Qkqk/J in 2002. This mutation was bred away from the T2J and Qkqk mutations by backcross-intercross to C57BL/6J selecting by phenotype. After the fifth backcross-intercross a change in breeding scheme was made to maintain this strain by sibling breeding heterozygous females with homozygous males. This strain reached generation N5F5 in 2006.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Ush1g
000783 B6.A-Ush1gjs/J View Strains carrying other alleles of Ush1g (1 strain)
Additional Web Information
Congenic Nomenclature
Genetic Quality Control Annual Report
Phenotype
Phenotype Information
assigned by genotype
Ush1gjs-2J/Ush1gjs-2J
B6(Cg)-Ush1gjs-2J/J
- hearing/vestibular/ear phenotype
- absent cochlear hair cells (MGI Ref ID J:112552)
- although gross abnormalities are not found, absence of hair cells is observed in the organ of Corti
- bi-directional circling (MGI Ref ID J:112552)
- deafness (MGI Ref ID J:112552)
- 100% of 12-54 day old homozygotes are deaf
- head tossing (MGI Ref ID J:112552)
- behavior/neurological phenotype
- bi-directional circling (MGI Ref ID J:112552)
- head tossing (MGI Ref ID J:112552)
- nervous system phenotype
- absent cochlear hair cells (MGI Ref ID J:112552)
- although gross abnormalities are not found, absence of hair cells is observed in the organ of Corti
- vision/eye phenotype
- *normal* vision/eye phenotype (MGI Ref ID J:112552)
- normal vision
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Ush1gjs-2J | ||
|---|---|---|---|
| Allele Name | Jackson shaker 2 Jackson | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | B6.Cg-T2J +/+ Qkqk/J | ||
| Gene Symbol and Name | Ush1g, Usher syndrome 1G homolog (human) | ||
| Chromosome | 11 | ||
| Gene Common Name(s) | ANKS4A; FLJ33924; Jackson shaker; SANS; Sans; js; scaffold protein, ankyrin repeats and SAM domain containing; | ||
| Molecular Note | A 155 base pair deletion was detected within exon 2 that induces a frame-shift coding for 51 altered amino acids followed by a premature stop codon. | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Optimizing PCR Protocols
References
References
Selected Reference(s)
Gagnon LH; Dais L; Johnson KR. 2006. Jackson-shaker 2J, a new spontaneous mouse mutation in the Ush1g gene MGI Direct Data Submission :. [MGI Ref ID J:112552]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number A1
Colony Maintenance
Breeding & Husbandry homozygous females will breed, but the litters often need to be fostered. Mating System Heterozygote x Homozygote (Female x Male)
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $166.30 Female or Male Heterozygous for Ush1gjs-2J $166.30 Female or Male Homozygous for Ush1gjs-2J *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $332.60 Heterozygous for Ush1gjs-2J x Heterozygous for Ush1gjs-2J $332.60 Heterozygous for Ush1gjs-2J x Homozygous for Ush1gjs-2J
Additional Supply Details
| Supply Notes |
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| Pricing for International shipping destinations |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $216.20 Female or Male Heterozygous for Ush1gjs-2J $216.20 Female or Male Homozygous for Ush1gjs-2J *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $432.40 Heterozygous for Ush1gjs-2J x Heterozygous for Ush1gjs-2J $432.40 Heterozygous for Ush1gjs-2J x Homozygous for Ush1gjs-2J
Additional Supply Details
| Supply Notes |
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
General Terms and Conditions
See Terms of Use
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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Contact Information
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Technical Support Email Form
Terms of Use
Terms of Use
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Contact information
General inquiries
Contracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
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