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Strain Name:

B6.Cg-Myo6sv-2J/J

Stock Number:

006124

Availability:

Repository- Live

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General Terms and Conditions

Genes & Alleles   Myo6;   Myo6sv-2J;

Product Information

Strain Details

Type JAX® GEMM® Strain - Congenic
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Mutant Strain
Type JAX® GEMM® Strain - Spontaneous Mutation
Mating SystemHeterozygote x Homozygote         (Female x Male)
Specieslaboratory mouse
GenerationN8F3 (06-DEC-07)

Appearance
black, with circling and head tossing
Related Genotype: Myo6sv-2J/Myo6sv-2J

black, unaffected
Related Genotype: Myo6sv-2J/+

Strain Development
The Snell’s waltzer 2 Jackson mutation arose spontaneously in the strain NOD.CB17-Prkdcscid/J (stock #001303) at The Jackson Laboratory in December, 1999. Homozygous males were bred to NOD.NON-H2nb1/LtJ and the offspring intercrossed. Mice lacking the Prkdcscid mutation were selected to continue the line. The Myo6sv-2J mutation was then transferred to the C57BL/6J background by backcross-intercross breeding, reaching NE8 in 2006 and then being maintained by sibling breeding heterozygous females with homozygous sibling males.

Mammalian Phenotype Terms assigned by genotype

Myo6sv-2J/Myo6sv-2J

        B6.Cg-Myo6sv-2J/J
  • behavior/neurological phenotype
  • circling (MGI Ref ID J:109355)
  • head tossing (MGI Ref ID J:109355)
  • impaired swimming (MGI Ref ID J:109355)
    • mutant mice roll and sink
  • hearing/vestibular/ear phenotype
  • circling (MGI Ref ID J:109355)
  • deafness (MGI Ref ID J:109355)
    • mice are deaf as assessed by ABR testing
  • head tossing (MGI Ref ID J:109355)

Gene & Allele Details

Allele Symbol Myo6sv-2J
Allele Name Snell's waltzer 2 Jackson
Strain of OriginNOD.CB17-Prkdcscid/J
Gene Symbol and Name Myo6, myosin VI
Chromosome 9
Gene Common Name(s) BC029719; DFNA22; DFNB37; KIAA0389; RGD1560646; Snell's waltzer; cDNA sequence BC029719; sv;
Molecular Note This mutation arose spontaneously at The Jackson Laboratory.

Control Information

  Control
   Heterozygote from the colony
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Myo6
008456   129S1/SvImJ-Myo6sv-4J/J
000578   B6 x STOCK Tyrc-ch Bmp5se +/+ Myo6sv/J
005749   C57BL/6J-Myo6sv-3J/J
View Strains carrying other alleles of Myo6     (3 strains)

Animal Health Reports

Room Number           A1

Research Applications

This mouse can be used to support research in many areas including:

Cell Biology Research
Vesicular Trafficking

Mouse/Human Gene Homologs
deafness, autosomal dominant nonsyndromic sensorineural 22 (DFNA22)
deafness, autosomal recessive nonsyndromic sensorineural 37 (DFNB37)

Neurobiology Research
Vestibular and Hearing Defects

Sensorineural Research
Vestibular and Hearing Defects

References

Selected Reference(s)

Longo-Guess C; Gagnon LH; Johnson KR. 2006. A new allele of myosin VI named Snell's Waltzer 2 Jackson MGI Direct Data Submission :.  [MGI Ref ID J:109355]

Original article from The Mouse Mutant Resource

Price and Supply Information

Strain Name: B6.Cg-Myo6sv-2J/J
Stock Number: 006124

Price Details

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Supply Details

Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes Usually shipped between four and eight weeks of age.
This strain is included in the Mouse Mutant Resource collection.
Genomic DNA is available for this strain from the Mouse DNA Resource.
LicensingSee General Terms and Conditions below  
Control InformationView Control Information in Strain Details.

General Terms and Conditions

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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