Description

Strain Information

Type Inbred Strain; Additional information on Inbred Strains. Species laboratory mouse Generation F?+19p

Appearance
albino
Related Genotype: a/a Tyr^c/Tyr^c

Description
The inbred strain, GR carries the Mtv2^a allele. This allele controls expression of endogenous MMTV and the early development of hormone-induced mammary tumors. Nearly all breeding females develop mammary tumors prior to one year of age (van Nie et al. 1977). Most females will exhibit small tumors by the day of first parturition (van Nie et al. 1971). These tumors are most often of the Dunn classification type B adenocarcinoma. MMTV is transmitted through both the milk and the germinal cells of both males and females. Foster nursing does not eliminate endogenous mammary tumor virus (Muhlbock 1965). MTV-antigens are detectable by immunodiffusion assay in the milk of the first lactation period. (van Nie et al. 1977). GR is used extensively to study endocrine regulation of mammary gland development and tumorigenesis.

Development
The GR strain was introduced to the Netherlands Cancer Institute in 1955 by professor Otto Muhlbock. He received breeding pairs from professor Grumbach, who had used these mice under the name 'Gunder strain' in his tuberculosis studies at the Institut fur Medizinische Mikrobologie der Universitat Zurich (Muhlbock O, 1965). The colony at the Netherlands Cancer Institute reached F68 in 1976. The history of this particular colony can be traced to 1986 where it was maintained at Albert Ochsner Medical Foundation in New Orleans, Louisiana. Sagres Discovery imported the colony from Dr. Om Prakash at Albert Ochsner in 2001 and maintained it as a private colony at The Jackson Laboratory. It was donated to The Jackson Laboratory Repository in 2006.

Related Strains

Strains carrying   Mtv2^a allele

006132

DDD.GR-Mtv2a/JmsJ

View Strains carrying   Mtv2^a     (1 strain)

Phenotype

Phenotype Information

View Phenotypic Data

Phenotypic Data

Festing Inbred Strain Characteristics: GRS

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Cancer Research
Increased Tumor Incidence (Mammary Gland Tumors)

Genes & Alleles

Gene & Allele Information

Allele Symbol		Mtv2a
Allele Name		mammary tumor virus locus 2, present
Allele Type		Not Applicable
Gene Symbol and Name		Mtv2, mammary tumor virus locus 2
Chromosome		18
Gene Common Name(s)		Mtv-2;
General Note		The provirus is present in the following strains: GR/Imr, GR, and SHN/Mei.

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Golovkina TV; Prakash O; Ross SR. 1996. Endogenous mouse mammary tumor virus Mtv-17 is involved in Mtv-2-induced tumorigenesis in GR mice. Virology 218(1):14-22. [PubMed: 8615016]  [MGI Ref ID J:33092]

Muhlbock O. 1965. Note on a new inbred mouse-strain GR-A. Eur J Cancer 1(2):123-4. [PubMed: 5874925]  [MGI Ref ID J:31560]

Muhlbock O. 1964. Note on a new inbred mouse strain GR/A Lillia Babbitt Hyde Foundation Conference on the Mammary Tumor Virus, Inverness, California 0((Abstr)):123-24.  [MGI Ref ID J:2462]

van Nie R; Dux A. 1971. Biological and morphological characteristics of mammary tumors in GR mice. J Natl Cancer Inst 46(4):885-97. [PubMed: 5573773]  [MGI Ref ID J:109202]

Additional References

Michalides R; van Deemter L; Nuss RR; van Nie R. 1978. Identification of the Mtv-2 gene responsible for the early appearance of mammary tumors in the GR mouse by nucleic acid hybridization. Proc Natl Acad Sci U S A 75(5):2368-72. [PubMed: 209461]  [MGI Ref ID J:6016]

Michalides R; van Nie R; Nusse R; Hynes NE; Groner B. 1981. Mammary tumor induction loci in GR and DBAf mice contain one provirus of the mouse mammary tumor virus. Cell 23(1):165-73. [PubMed: 6260372]  [MGI Ref ID J:32351]

Van Nie R; Verstraeten AA; De Moes J. 1977. Genetic transmission of mammary tumour virus by GR mice. Int J Cancer 19(3):383-90. [PubMed: 191409]  [MGI Ref ID J:5785]

van Nie R; Hilgers J. 1976. Genetic analysis of mammary tumor induction and expression of mammary tumor virus antigen in hormone-treated ovariectomized GR mice. J Natl Cancer Inst 56(1):27-32. [PubMed: 176379]  [MGI Ref ID J:5626]

Mtv2^a related

Koizumi A; Tsukada M; Wada Y; Kamiyama S. 1990. Demonstration of a new mouse mammary tumor virus locus in the genome of the mammary tumor prone strain SHN mouse. Biochem Biophys Res Commun 166(1):336-41. [PubMed: 2154203]  [MGI Ref ID J:21257]

MacInnes JI; Morris VL; Flintoff WF; Kozak CA. 1984. Characterization and chromosomal location of endogenous mouse mammary tumor virus loci in GR, NFS, and DBA mice. Virology 132(1):12-25. [PubMed: 6320529]  [MGI Ref ID J:7326]

Wajjwalku W; Takahashi M; Miyaishi O; Lu J; Sakata K; Yokoi T; Saga S; Imai M; Matsuyama M; Hoshino M. 1991. Tissue distribution of mouse mammary tumor virus (MMTV) antigens and new endogenous MMTV loci in Japanese laboratory mouse strains. Jpn J Cancer Res 82(12):1413-20. [PubMed: 1663921]  [MGI Ref ID J:1887]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Supply Details

Standard Supply

Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.

Supply Notes

Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845. This strain is included in the Mouse Mutant Resource collection.

General Terms and Conditions

See Terms of Use

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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