Strain Name:

GR/J

Stock Number:

006131

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Availability:

Cryopreserved - Ready for recovery

Common Names: GR/A;     GRS;     GRS/A;    
The inbred strain, GR, carries the Mtv2a allele. This allele controls expression of endogenous MMTV and the early development of hormone-induced mammary tumors. Nearly all breeding females develop mammary tumors prior to one year of age. GR is used to study endocrine regulation of mammary gland development and tumorigenesis.

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Inbred Strain;
Additional information on Inbred Strains.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
GenerationF?+19p
Generation Definitions

Appearance
albino
Related Genotype: a/a Tyrc/Tyrc

Description
The inbred strain, GR carries the Mtv2a allele. This allele controls expression of endogenous MMTV and the early development of hormone-induced mammary tumors. Nearly all breeding females develop mammary tumors prior to one year of age (van Nie et al. 1977). Most females will exhibit small tumors by the day of first parturition (van Nie et al. 1971). These tumors are most often of the Dunn classification type B adenocarcinoma. MMTV is transmitted through both the milk and the germinal cells of both males and females. Foster nursing does not eliminate endogenous mammary tumor virus (Muhlbock 1965). MTV-antigens are detectable by immunodiffusion assay in the milk of the first lactation period. (van Nie et al. 1977). GR is used extensively to study endocrine regulation of mammary gland development and tumorigenesis.

Development
The GR strain was introduced to the Netherlands Cancer Institute in 1955 by professor Otto Muhlbock. He received breeding pairs from professor Grumbach, who had used these mice under the name 'Gunder strain' in his tuberculosis studies at the Institut fur Medizinische Mikrobologie der Universitat Zurich (Muhlbock O, 1965). The colony at the Netherlands Cancer Institute reached F68 in 1976. The history of this particular colony can be traced to 1986 where it was maintained at Albert Ochsner Medical Foundation in New Orleans, Louisiana. Sagres Discovery imported the colony from Dr. Om Prakash at Albert Ochsner in 2001 and maintained it as a private colony at The Jackson Laboratory. It was donated to The Jackson Laboratory Repository in 2006.

Related Strains

Strains carrying   Mtv2a allele
006132   DDD.GR-Mtv2a/JmsJ
003153   WLC.Cg-H2d Mtv2a/MorJ
View Strains carrying   Mtv2a     (2 strains)

Phenotype

Phenotype Information

View Phenotypic Data

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cancer Research
Increased Tumor Incidence
      Mammary Gland Tumors

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Mtv2a
Allele Name mammary tumor virus locus 2, present
Allele Type Not Applicable
Gene Symbol and Name Mtv2, mammary tumor virus locus 2
Chromosome 18
Gene Common Name(s) Mtv-2;
General Note The provirus is present in the following strains: GR/Imr, GR, and SHN/Mei.

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Golovkina TV; Prakash O; Ross SR. 1996. Endogenous mouse mammary tumor virus Mtv-17 is involved in Mtv-2-induced tumorigenesis in GR mice. Virology 218(1):14-22. [PubMed: 8615016]  [MGI Ref ID J:33092]

Muhlbock O. 1964. Note on a new inbred mouse strain GR/A Lillia Babbitt Hyde Foundation Conference on the Mammary Tumor Virus, Inverness, California 0((Abstr)):123-24.  [MGI Ref ID J:2462]

Muhlbock O. 1965. Note on a new inbred mouse-strain GR-A. Eur J Cancer 1(2):123-4. [PubMed: 5874925]  [MGI Ref ID J:31560]

van Nie R; Dux A. 1971. Biological and morphological characteristics of mammary tumors in GR mice. J Natl Cancer Inst 46(4):885-97. [PubMed: 5573773]  [MGI Ref ID J:109202]

Additional References

Michalides R; van Deemter L; Nuss RR; van Nie R. 1978. Identification of the Mtv-2 gene responsible for the early appearance of mammary tumors in the GR mouse by nucleic acid hybridization. Proc Natl Acad Sci U S A 75(5):2368-72. [PubMed: 209461]  [MGI Ref ID J:6016]

Michalides R; van Nie R; Nusse R; Hynes NE; Groner B. 1981. Mammary tumor induction loci in GR and DBAf mice contain one provirus of the mouse mammary tumor virus. Cell 23(1):165-73. [PubMed: 6260372]  [MGI Ref ID J:32351]

Van Nie R; Verstraeten AA; De Moes J. 1977. Genetic transmission of mammary tumour virus by GR mice. Int J Cancer 19(3):383-90. [PubMed: 191409]  [MGI Ref ID J:5785]

van Nie R; Hilgers J. 1976. Genetic analysis of mammary tumor induction and expression of mammary tumor virus antigen in hormone-treated ovariectomized GR mice. J Natl Cancer Inst 56(1):27-32. [PubMed: 176379]  [MGI Ref ID J:5626]

Mtv2a related

Koizumi A; Tsukada M; Wada Y; Kamiyama S. 1990. Demonstration of a new mouse mammary tumor virus locus in the genome of the mammary tumor prone strain SHN mouse. Biochem Biophys Res Commun 166(1):336-41. [PubMed: 2154203]  [MGI Ref ID J:21257]

MacInnes JI; Morris VL; Flintoff WF; Kozak CA. 1984. Characterization and chromosomal location of endogenous mouse mammary tumor virus loci in GR, NFS, and DBA mice. Virology 132(1):12-25. [PubMed: 6320529]  [MGI Ref ID J:7326]

Matsuzawa A; Sayama K; Tsubura A; Murakami A. 1990. A congenic line of the DDD mouse strain, DDD/1-Mtv-2/Mtv-2: establishment and mammary tumorigenesis. Jpn J Cancer Res 81(6-7):639-44. [PubMed: 1976120]  [MGI Ref ID J:109201]

Wajjwalku W; Takahashi M; Miyaishi O; Lu J; Sakata K; Yokoi T; Saga S; Imai M; Matsuyama M; Hoshino M. 1991. Tissue distribution of mouse mammary tumor virus (MMTV) antigens and new endogenous MMTV loci in Japanese laboratory mouse strains. Jpn J Cancer Res 82(12):1413-20. [PubMed: 1663921]  [MGI Ref ID J:1887]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2450.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3185.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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