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| Transgene expression in the differentiated endothelium of these mice is observed as early as E7.5 and progresses to almost full penetrance by E14.5. In adult mice, uniform cre expression is observed in the endothelium of developing and quiescent vessels of all organs examined, as well as within a subset of hematopoietic cells. When bred with any mouse containing a loxP-flanked sequence of interest, Cre-mediated recombination will result in deletion of the flanked genome. These mice may be useful in studies of the cardiovascular system, including angiogenesis, and endothelial and hematopoietic cell lineages. | |||||||||||||||||||
- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
- Terms of use
Description
Strain Information
Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote (Female x Male) 05-SEP-08 Species laboratory mouse Generation N12+F12N1F1 (16-OCT-12)
Generation DefinitionsDonating Investigator M. Luisa Iruela-Arispe, University of California, Los Angeles Description
Hemizygotes are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. In the differentiated endothelium transgene expression is observed as early as E7.5 and progresses to almost full penetrance by E14.5. In adult mice, uniform cre expression is observed in the endothelium of developing and quiescent vessels of all organs examined, as well as within a subset of hematopoietic cells. When bred with any mouse containing a loxP-flanked sequence of interest, Cre-mediated recombination will result in deletion of the flanked genome. These mice may be useful in studies of the cardiovascular system, including angiogenesis, and endothelial and hematopoietic cell lineages.These mice exhibit less efficient cre-mediated recombination than B6.Cg-Tg(Cdh5-cre)1Spe/J mice (Stock No. 017968), in which cre activity is seen in 85% of the fetal liver population and 96% of adult bone marrow.
View cre expression characterization.
Development
A recombinant vector was designed to place Cre recombinase cDNA downstream from a 2.5-kb fragment of the VE-Cadherin (Cdh5) mouse promoter. This construct was microinjected into FVB/N fertilized oocytes. A selected founder line ("VEN7-CRE") was established and then backcrossed to C57BL/6 for 12 generations prior to sending to The Jackson Laboratory Repository (in 2007). Upon arrival, transgenic mice were bred to C57BL/6J inbred mice (Stock No. 000664) for at least one generation to establish the colony. After this, the colony was maintained for several generations by breeding transgenic mice together.In 2011, a 32 SNP (single nucleotide polymorphism) panel analysis, with markers covering all 19 chromosomes and the X chromosome, was performed on the rederived living colony at The Jackson Laboratory Repository. This revealed 4 markers that were not C57BL/6 allele-type. Specifically, one marker on chromosome 4 (~20.0 Mbp), two markers on chromosome 8 (~14.8 Mbp and ~15.2 Mbp), and one marker on chromosome 19 (~50.1 Mbp) were homozygous for FVB allele-type. Of note, a marker on chromosome 19 at ~20.5 Mbp is homozygous for C57BL/6 allele-type. These data may suggest possible transgene insertion sites, and/or that the mice were not backcrossed to C57BL/6 for as many generations as originally reported prior to arrival at The Jackson Laboratory Repository.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Cdh5
017968 B6;129-Tg(Cdh5-cre)1Spe/J 013585 FVB-Tg(Cdh5-tTA)D5Lbjn/J View Strains carrying other alleles of Cdh5 (2 strains)
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Tg(Cdh5-cre)7Mlia/0
involves: FVB/N
- normal phenotype
- no abnormal phenotype detected
- mice are viable and fertile; no phenotypic abnormalities are detected (MGI Ref ID J:106155)
This mouse can be used to support research in many areas including:
cre relatedCardiovascular Research
Vascular Defects
Developmental Biology Research
Internal/Organ Defects
hematopoietic defects
vasculature
Hematological Research
Hematopoietic Defects
Research Tools
Cancer Research
endothelial cell marker for neovascularization
Cardiovascular Research
Cre-lox System
endothelial cell marker for neovascularization
Cre-lox System
Cre Recombinase Expression
Cre Recombinase Expression: Germline/Embryonic Expression
Developmental Biology Research
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Tissue/Cell Markers
Tissue/Cell Markers: Cre-lox System
Tissue/Cell Markers: endothelial cell markers for neovascularization
Hematological Research
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(Cdh5-cre)7Mlia | ||
|---|---|---|---|
| Allele Name | transgene insertion 7, M Luisa Iruela-Arispe | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | Tg(Cdh5-cre)1Mlia; VE-Cadherin-Cre; VEC-Cre; VEN7-CRE; | ||
| Mutation Made By | M. Luisa Iruela-Arispe, University of California, Los Angeles | ||
| Strain of Origin | FVB/N | ||
| Site of Expression | Embryonic and adult expression in endothelium of developing and quiescent vessels of all organs examined, as well as within a subset of hematopoietic cells. | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Cdh5, cadherin 5, mouse, laboratory | ||
| Driver Note | Cdh5 | ||
| Molecular Note | The cadherin 5 promoter was used to drive expression of cre recombinase in the adult epithelium. Three lines were created. [MGI Ref ID J:106155] | ||
| Gene Symbol and Name | Tg(Cdh5-cre)7Mlia, transgene insertion 7, M Luisa Iruela-Arispe | ||
| Chromosome | UN | ||
| Gene Common Name(s) | Tg(Cdh5-cre)1Mlia; VE-Cadherin-Cre; VEC-Cre; VEN7-CRE; transgene insertion 1, M Luisa Iruela-Arispe; | ||
Genotyping
Genotyping Information
Genotyping Protocols
Tg(Cdh5-cre)7Mlia-alternate1,Separated MCA
Generic Cre Melt Curve Analysis, Melt Curve Analysis
Generic Cre Quantitative PCR, QPCR
Generic Cre, Standard PCR
Tg(Cdh5-cre)7Mlia-alternate1, Separated PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Alva JA; Zovein AC; Monvoisin A; Murphy T; Salazar A; Harvey NL; Carmeliet P; Iruela-Arispe ML. 2006. VE-Cadherin-Cre-recombinase transgenic mouse: A tool for lineage analysis and gene deletion in endothelial cells. Dev Dyn 235(3):759-67. [PubMed: 16450386] [MGI Ref ID J:106155]
Additional References
Tg(Cdh5-cre)7Mlia relatedBerry R; Rodeheffer MS. 2013. Characterization of the adipocyte cellular lineage in vivo. Nat Cell Biol 15(3):302-8. [PubMed: 23434825] [MGI Ref ID J:195198]
Corada M; Nyqvist D; Orsenigo F; Caprini A; Giampietro C; Taketo MM; Iruela-Arispe ML; Adams RH; Dejana E. 2010. The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling. Dev Cell 18(6):938-49. [PubMed: 20627076] [MGI Ref ID J:163848]
Economopoulou M; Langer HF; Celeste A; Orlova VV; Choi EY; Ma M; Vassilopoulos A; Callen E; Deng C; Bassing CH; Boehm M; Nussenzweig A; Chavakis T. 2009. Histone H2AX is integral to hypoxia-driven neovascularization. Nat Med 15(5):553-8. [PubMed: 19377486] [MGI Ref ID J:149487]
Gandhirajan RK; Meng S; Chandramoorthy HC; Mallilankaraman K; Mancarella S; Gao H; Razmpour R; Yang XF; Houser SR; Chen J; Koch WJ; Wang H; Soboloff J; Gill DL; Madesh M. 2013. Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation. J Clin Invest :. [PubMed: 23348743] [MGI Ref ID J:194484]
Genetic Resource Sciences at The Jackson Laboratory. 2012. Expression/Specificity Patterns of Cre Alleles, 2011 MGI Direct Data Submission :. [MGI Ref ID J:184578]
Genetic Resource Sciences at The Jackson Laboratory. 2008. Expression/Specificity patterns of Cre transgenes MGI Direct Data Submission :. [MGI Ref ID J:137887]
Greif DM; Kumar M; Lighthouse JK; Hum J; An A; Ding L; Red-Horse K; Espinoza FH; Olson L; Offermanns S; Krasnow MA. 2012. Radial construction of an arterial wall. Dev Cell 23(3):482-93. [PubMed: 22975322] [MGI Ref ID J:189012]
Grenz A; Bauerle JD; Dalton JH; Ridyard D; Badulak A; Tak E; McNamee EN; Clambey E; Moldovan R; Reyes G; Klawitter J; Ambler K; Magee K; Christians U; Brodsky KS; Ravid K; Choi DS; Wen J; Lukashev D; Blackburn MR; Osswald H; Coe IR; Nurnberg B; Haase VH;Xia Y; Sitkovsky M; Eltzschig HK. 2012. Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice. J Clin Invest 122(2):693-710. [PubMed: 22269324] [MGI Ref ID J:184493]
Guo W; Lasky JL; Chang CJ; Mosessian S; Lewis X; Xiao Y; Yeh JE; Chen JY; Iruela-Arispe ML; Varella-Garcia M; Wu H. 2008. Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation. Nature 453(7194):529-33. [PubMed: 18463637] [MGI Ref ID J:135172]
Guo W; Schubbert S; Chen JY; Valamehr B; Mosessian S; Shi H; Dang NH; Garcia C; Theodoro MF; Varella-Garcia M; Wu H. 2011. Suppression of leukemia development caused by PTEN loss. Proc Natl Acad Sci U S A 108(4):1409-14. [PubMed: 21212363] [MGI Ref ID J:168259]
Harel I; Nathan E; Tirosh-Finkel L; Zigdon H; Guimaraes-Camboa N; Evans SM; Tzahor E. 2009. Distinct origins and genetic programs of head muscle satellite cells. Dev Cell 16(6):822-32. [PubMed: 19531353] [MGI Ref ID J:150129]
Hofmann JJ; Briot A; Enciso J; Zovein AC; Ren S; Zhang ZW; Radtke F; Simons M; Wang Y; Iruela-Arispe ML. 2012. Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome. Development 139(23):4449-60. [PubMed: 23095891] [MGI Ref ID J:189213]
Hofmann JJ; Zovein AC; Koh H; Radtke F; Weinmaster G; Iruela-Arispe ML. 2010. Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome. Development 137(23):4061-72. [PubMed: 21062863] [MGI Ref ID J:166890]
Langer HF; Orlova VV; Xie C; Kaul S; Schneider D; Lonsdorf AS; Fahrleitner M; Choi EY; Dutoit V; Pellegrini M; Grossklaus S; Nawroth PP; Baretton G; Santoso S; Hwang ST; Arnold B; Chavakis T. 2011. A Novel Function of Junctional Adhesion Molecule-C in Mediating Melanoma Cell Metastasis. Cancer Res 71(12):4096-4105. [PubMed: 21593193] [MGI Ref ID J:173391]
Lee S; Chen TT; Barber CL; Jordan MC; Murdock J; Desai S; Ferrara N; Nagy A; Roos KP; Iruela-Arispe ML. 2007. Autocrine VEGF signaling is required for vascular homeostasis. Cell 130(4):691-703. [PubMed: 17719546] [MGI Ref ID J:124900]
Li Z; Lan Y; He W; Chen D; Wang J; Zhou F; Wang Y; Sun H; Chen X; Xu C; Li S; Pang Y; Zhang G; Yang L; Zhu L; Fan M; Shang A; Ju Z; Luo L; Ding Y; Guo W; Yuan W; Yang X; Liu B. 2012. Mouse embryonic head as a site for hematopoietic stem cell development. Cell Stem Cell 11(5):663-75. [PubMed: 23122290] [MGI Ref ID J:193721]
Monvoisin A; Alva JA; Hofmann JJ; Zovein AC; Lane TF; Iruela-Arispe ML. 2006. VE-cadherin-CreERT2 transgenic mouse: a model for inducible recombination in the endothelium. Dev Dyn 235(12):3413-22. [PubMed: 17072878] [MGI Ref ID J:116638]
Myers SA; DeVries WH; Andres KR; Gruenthal MJ; Benton RL; Hoying JB; Hagg T; Whittemore SR. 2011. CD47 knockout mice exhibit improved recovery from spinal cord injury. Neurobiol Dis 42(1):21-34. [PubMed: 21168495] [MGI Ref ID J:170731]
Nitschke M; Aebischer D; Abadier M; Haener S; Lucic M; Vigl B; Luche H; Fehling HJ; Biehlmaier O; Lyck R; Halin C. 2012. Differential requirement for ROCK in dendritic cell migration within lymphatic capillaries in steady-state and inflammation. Blood 120(11):2249-58. [PubMed: 22855606] [MGI Ref ID J:191311]
Okuno Y; Nakamura-Ishizu A; Otsu K; Suda T; Kubota Y. 2012. Pathological neoangiogenesis depends on oxidative stress regulation by ATM. Nat Med :. [PubMed: 22797809] [MGI Ref ID J:192791]
Pasula S; Cai X; Dong Y; Messa M; McManus J; Chang B; Liu X; Zhu H; Mansat RS; Yoon SJ; Hahn S; Keeling J; Saunders D; Ko G; Knight J; Newton G; Luscinskas F; Sun X; Towner R; Lupu F; Xia L; Cremona O; De Camilli P; Min W; Chen H. 2012. Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling. J Clin Invest 122(12):4424-38. [PubMed: 23187125] [MGI Ref ID J:193966]
Red-Horse K; Ueno H; Weissman IL; Krasnow MA. 2010. Coronary arteries form by developmental reprogramming of venous cells. Nature 464(7288):549-53. [PubMed: 20336138] [MGI Ref ID J:158886]
Ruiz-Herguido C; Guiu J; D'Altri T; Ingles-Esteve J; Dzierzak E; Espinosa L; Bigas A. 2012. Hematopoietic stem cell development requires transient Wnt/beta-catenin activity. J Exp Med 209(8):1457-68. [PubMed: 22802352] [MGI Ref ID J:189158]
Satyanarayana A; Gudmundsson KO; Chen X; Coppola V; Tessarollo L; Keller JR; Hou SX. 2010. RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis. Blood 116(16):2921-31. [PubMed: 20595512] [MGI Ref ID J:165879]
Shoham AB; Malkinson G; Krief S; Shwartz Y; Ely Y; Ferrara N; Yaniv K; Zelzer E. 2012. S1P1 inhibits sprouting angiogenesis during vascular development. Development 139(20):3859-69. [PubMed: 22951644] [MGI Ref ID J:187683]
Skuli N; Liu L; Runge A; Wang T; Yuan L; Patel S; Iruela-Arispe L; Simon MC; Keith B. 2009. Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis. Blood 114(2):469-77. [PubMed: 19439736] [MGI Ref ID J:150753]
Skuli N; Majmundar AJ; Krock BL; Mesquita RC; Mathew LK; Quinn ZL; Runge A; Liu L; Kim MN; Liang J; Schenkel S; Yodh AG; Keith B; Simon MC. 2012. Endothelial HIF-2alpha regulates murine pathological angiogenesis and revascularization processes. J Clin Invest 122(4):1427-43. [PubMed: 22426208] [MGI Ref ID J:184551]
Tang Y; Harrington A; Yang X; Friesel RE; Liaw L. 2010. The contribution of the Tie2+ lineage to primitive and definitive hematopoietic cells. Genesis 48(9):563-7. [PubMed: 20645309] [MGI Ref ID J:170016]
Van Handel B; Montel-Hagen A; Sasidharan R; Nakano H; Ferrari R; Boogerd CJ; Schredelseker J; Wang Y; Hunter S; Org T; Zhou J; Li X; Pellegrini M; Chen JN; Orkin SH; Kurdistani SK; Evans SM; Nakano A; Mikkola HK. 2012. Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Cell 150(3):590-605. [PubMed: 22863011] [MGI Ref ID J:187883]
Zhong Z; Ilieva H; Hallagan L; Bell R; Singh I; Paquette N; Thiyagarajan M; Deane R; Fernandez JA; Lane S; Zlokovic AB; Liu T; Griffin JH; Chow N; Castellino FJ; Stojanovic K; Cleveland DW; Zlokovic BV. 2009. Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. J Clin Invest 119(11):3437-49. [PubMed: 19841542] [MGI Ref ID J:154597]
Zhou G; Hamik A; Nayak L; Tian H; Shi H; Lu Y; Sharma N; Liao X; Hale A; Boerboom L; Feaver RE; Gao H; Desai A; Schmaier A; Gerson SL; Wang Y; Atkins GB; Blackman BR; Simon DI; Jain MK. 2012. Endothelial Kruppel-like factor 4 protects against atherothrombosis in mice. J Clin Invest 122(12):4727-31. [PubMed: 23160196] [MGI Ref ID J:193972]
Zovein AC; Hofmann JJ; Lynch M; French WJ; Turlo KA; Yang Y; Becker MS; Zanetta L; Dejana E; Gasson JC; Tallquist MD; Iruela-Arispe ML. 2008. Fate tracing reveals the endothelial origin of hematopoietic stem cells. Cell Stem Cell 3(6):625-36. [PubMed: 19041779] [MGI Ref ID J:149863]
Zovein AC; Luque A; Turlo KA; Hofmann JJ; Yee KM; Becker MS; Fassler R; Mellman I; Lane TF; Iruela-Arispe ML. 2010. Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism. Dev Cell 18(1):39-51. [PubMed: 20152176] [MGI Ref ID J:157920]
Zovein AC; Turlo KA; Ponec RM; Lynch MR; Chen KC; Hofmann JJ; Cox TC; Gasson JC; Iruela-Arispe ML. 2010. Vascular remodeling of the vitelline artery initiates extravascular emergence of hematopoietic clusters. Blood 116(18):3435-44. [PubMed: 20699440] [MGI Ref ID J:166646]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX11
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, transgenic mice can be bred to wildtype siblings, C57BL/6J, or bred together to generate homozygous colonies. Mating System Homozygote x Homozygote (Female x Male) 05-SEP-08 Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $232.00 Female or Male Homozygous for Tg(Cdh5-cre)7Mlia
Price per Pair (US dollars $) Pair Genotype $464.00 Homozygous for Tg(Cdh5-cre)7Mlia x Homozygous for Tg(Cdh5-cre)7Mlia Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
| Pricing for International shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $301.60 Female or Male Homozygous for Tg(Cdh5-cre)7Mlia
Price per Pair (US dollars $) Pair Genotype $603.20 Homozygous for Tg(Cdh5-cre)7Mlia x Homozygous for Tg(Cdh5-cre)7Mlia Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
|
|
|
Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
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The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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