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Description
Strain Information
Type Congenic; Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote (Female x Male) 08-SEP-06 Species laboratory mouse Generation N6+F7 (05-JAN-09) Donating Investigator Frank Costantini, Columbia University Description
Mice that are homozygous for the mutant allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. These mice contain an Enhanced Yellow Fluorescent Protein gene (EYFP, Clonetech) inserted into the Gt(ROSA)26Sor locus. Expression of EYFP is blocked by an upstream loxP-flanked STOP sequence. When bred to mice with a cre recombinase gene under the control of a promoter of interest, the STOP sequence of the targeted gene is deleted in the tissue of interest, and EYFP expression is observed. These mutant mice may be useful in monitoring the Cre expression in living tissues, and tracing the lineage of such cells in embryos, young, and adult mice at desired time points.Mutant mice maintained on a genetic background containing a contribution from C57BL/6J have the potential to harbor a loss-of-function mutation in the nicotinamide (NAD) nucleotide transhydrogenase gene (Nnt, Chromosome 13). This Nnt mutation arose spontaneously in C57BL/6J sometime prior to 1984. It has been confirmed that this strain (Stock No. 006148) is homozygous for the Nnt mutant allele. For a more detailed description, please see the JAX Mice and Services article "Nnt Alleles in C57BL/6 Mice".
Development
A targeting vector was designed to contain the Enhanced Yellow Fluorescent Protein gene (from the pEYFP-N1 plasmid, Clonetech) downstream of a loxP-flanked stop sequence (neomycin resistance gene and a trimer of the SV40 polyadenylation sequence). This entire construct was inserted into the Gt(ROSA)26Sor locus via electroporation of 129X1/SvJ-derived JM-1 embryonic stem (ES) cells. Correctly targeted ES cells were microinjected in C57BL/6J blastocysts. Chimeric male Y8-8 was bred to a C57BL/6J female mouse. Mutant male progeny were backcrossed to C57BL/6J for 6 generations and then made homozygous prior to sending to The Jackson Laboratory. The Y chromosome may not be fixed to the C57BL/6 genetic background.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Fluorescent Protein Strains
View Fluorescent Protein Strains (223 strains)
005483 129-Tg(CAG-EYFP)7AC5Nagy/J 008299 B6.Cg-Tg(NEFL-EYFP/Nefh)40Gsn/J 007901 B6.Cg-Tg(Thy1-Brainbow1.0)HLich/J 007911 B6.Cg-Tg(Thy1-Brainbow1.1)MLich/J 007921 B6.Cg-Tg(Thy1-Brainbow2.1)RLich/J 007612 B6.Cg-Tg(Thy1-COP4/EYFP)18Gfng/J 007615 B6.Cg-Tg(Thy1-COP4/EYFP)9Gfng/J 005630 B6.Cg-Tg(Thy1-EYFP)15Jrs/J 003709 B6.Cg-Tg(Thy1-YFP)16Jrs/J 005627 B6.Cg-Tg(Thy1-YFP/Syp)10Jrs/J 003782 B6.Cg-Tg(Thy1-YFPH)2Jrs/J 007606 B6.Cg-Tg(Thy1-cre/ESR1,-EYFP)AGfng/J 008636 B6;C-Tg(Prnp-APP695*/EYFP)49Gsn/J 007910 B6;CBA-Tg(Thy1-Brainbow1.0)LLich/J 005620 B6;D2-Tg(S100B-EYFP)1Wjt/J 007610 B6;SJL-Tg(Thy1-cre/ESR1,-EYFP)VGfng/J 007880 B6SJL-Tg(Thy1-Stx1a/EYFP)1Sud/J 006618 C57BL/6-Tg(tetO-COX8A/EYFP)1Ksn/J 006362 C57BL/6J-Tg(CMV-Cox8a/EYFP)17J/J 007857 C57BL/6J-Tg(Eno2-YFP/Cox8a)YRwb/J 007860 C57BL/6J-Tg(Eno2-YFP/Cox8a)ZRwb/J 009422 NOD.Cg-Tg(Itgax-EYFP)1Mnz/QtngJ 005130 STOCK Gt(ROSA)26Sortm1(Smo/EYFP)Amc/J
Additional Web Information
Fluorescent Proteins/lacZ Systems
Introduction to Cre-lox technology
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
YFP relatedNeurobiology Research
Cre-lox System
loxP-flanked Sequences: Test/Reporter
Research Tools
Cre-lox System
loxP-flanked Sequences: Test/Reporter
Developmental Biology Research
Cre-lox System
Fluorescent Proteins
Research Tools
Fluorescent Proteins
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Gt(ROSA)26Sortm1(EYFP)Cos | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Frank Costantini | ||
| Allele Type | Targeted (Reporter) | ||
| Common Name(s) | R26-stop-EYFP; R26R EYFP; R26R-EYFP; R26RYFP; R26RYFP; ROSA26-LoxP-STOP-LoxP-EYFP; ROSA26-YFP; ROSA26-loxP-Stop-loxP-YF; ROSA26-stop-YFP reporter; ROSA26R-YFP; Rosa26-YFPfl; Rosa26YFPStop; Rosa26YFP; | ||
| Mutation Made By | Frank Costantini, Columbia University | ||
| Strain of Origin | 129X1/SvJ | ||
| ES Cell Line Name | JM-1 | ||
| ES Cell Line Strain | 129X1/SvJ | ||
| Site of Expression | when crossed to a cre recombinase-expressing strain, Enhanced Yellow Fluorescent Protein expression is observed in the cre-expressing tissues | ||
| Expressed Gene | YFP, Yellow Fluorescent Protein, jellyfish | ||
| Yellow Fluorescent Protein (YFP) is a derivative of Green Fluorescent Protein (GFP), a versatile reporter molecule which has found use in many biological applications. The original molecule has been modified in order to enhance fluorescence intensity and shift the wavelength emitted when excited. When YFP is utilized in a transgenic construct, tissue expressing sufficient amounts of YFP will fluoresce yellowish-green when exposed to a 513 nm light source. | |||
| Gene Symbol and Name | Gt(ROSA)26Sor, gene trap ROSA 26, Philippe Soriano | ||
| Chromosome | 6 | ||
| Gene Common Name(s) | AV258896; Gtrgeo26; Gtrosa26; R26; ROSA26; beta geo; expressed sequence AV258896; gene trap ROSA 26; gene trap ROSA b-geo 26; | ||
| Molecular Note | A construct containing a floxed PGK-neo cassette and an enhanced yellow fluorescent protein (EYFP) gene was inserted into the Gt(ROSA)26Sor locus via homologous recombination. The floxed neo cassette contains a strong tpA stop sequence which prevents thetranscription of EYFP. [MGI Ref ID J:80963] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Gt(Rosa)26Sortm1(EYFP)Cos, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References
Additional References
Gt(ROSA)26Sortm1(EYFP)Cos relatedBalordi F; Fishell G. 2007. Mosaic removal of hedgehog signaling in the adult SVZ reveals that the residual wild-type stem cells have a limited capacity for self-renewal. J Neurosci 27(52):14248-59. [PubMed: 18160632] [MGI Ref ID J:130973]
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Cai J; Chen Y; Cai WH; Hurlock EC; Wu H; Kernie SG; Parada LF; Lu QR. 2007. A crucial role for Olig2 in white matter astrocyte development. Development 134(10):1887-99. [PubMed: 17428828] [MGI Ref ID J:121422]
Camerer E; Regard JB; Cornelissen I; Srinivasan Y; Duong DN; Palmer D; Pham TH; Wong JS; Pappu R; Coughlin SR. 2009. Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. J Clin Invest 119(7):1871-9. [PubMed: 19603543] [MGI Ref ID J:152547]
Casola S; Cattoretti G; Uyttersprot N; Koralov SB; Segal J; Hao Z; Waisman A; Egert A; Ghitza D; Rajewsky K. 2006. Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting. Proc Natl Acad Sci U S A 103(19):7396-401. [PubMed: 16651521] [MGI Ref ID J:109583]
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Claret M; Smith MA; Batterham RL; Selman C; Choudhury AI; Fryer LG; Clements M; Al-Qassab H; Heffron H; Xu AW; Speakman JR; Barsh GS; Viollet B; Vaulont S; Ashford ML; Carling D; Withers DJ. 2007. AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. J Clin Invest 117(8):2325-36. [PubMed: 17671657] [MGI Ref ID J:123951]
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Croxford AL; Kurschus FC; Waisman A. 2009. Cutting edge: An IL-17F-CreEYFP reporter mouse allows fate mapping of Th17 cells. J Immunol 182(3):1237-41. [PubMed: 19155467] [MGI Ref ID J:144336]
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Druckenbrod NR; Epstein ML. 2009. Age-dependent changes in the gut environment restrict the invasion of the hindgut by enteric neural progenitors. Development 136(18):3195-203. [PubMed: 19700623] [MGI Ref ID J:152317]
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Fujitani Y; Fujitani S; Luo H; Qiu F; Burlison J; Long Q; Kawaguchi Y; Edlund H; Macdonald RJ; Furukawa T; Fujikado T; Magnuson MA; Xiang M; Wright CV. 2006. Ptf1a determines horizontal and amacrine cell fates during mouse retinal development. Development 133(22):4439-50. [PubMed: 17075007] [MGI Ref ID J:115271]
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Maatouk DM; Loveland KL; McManus MT; Moore K; Harfe BD. 2008. Dicer1 is required for differentiation of the mouse male germline. Biol Reprod 79(4):696-703. [PubMed: 18633141] [MGI Ref ID J:140872]
Malanchi I; Peinado H; Kassen D; Hussenet T; Metzger D; Chambon P; Huber M; Hohl D; Cano A; Birchmeier W; Huelsken J. 2008. Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling. Nature 452(7187):650-3. [PubMed: 18385740] [MGI Ref ID J:133779]
Marie JC; Liggitt D; Rudensky AY. 2006. Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity 25(3):441-54. [PubMed: 16973387] [MGI Ref ID J:113553]
Means AL; Xu Y; Zhao A; Ray KC; Gu G. 2008. A CK19(CreERT) knockin mouse line allows for conditional DNA recombination in epithelial cells in multiple endodermal organs. Genesis 46(6):318-23. [PubMed: 18543299] [MGI Ref ID J:136694]
Moncrieffe H; Coles M; Stockinger B. 2008. The influence of CD4 T-cell subsets on control of CD4 T-cell-mediated graft-versus-host disease. Immunology 125(4):459-68. [PubMed: 18498346] [MGI Ref ID J:144443]
Moore DL; Blackmore MG; Hu Y; Kaestner KH; Bixby JL; Lemmon VP; Goldberg JL. 2009. KLF family members regulate intrinsic axon regeneration ability. Science 326(5950):298-301. [PubMed: 19815778] [MGI Ref ID J:153499]
Mugford JW; Sipila P; Kobayashi A; Behringer RR; McMahon AP. 2008. Hoxd11 specifies a program of metanephric kidney development within the intermediate mesoderm of the mouse embryo. Dev Biol 319(2):396-405. [PubMed: 18485340] [MGI Ref ID J:137524]
Murdoch B; Roskams AJ. 2008. A novel embryonic nestin-expressing radial glia-like progenitor gives rise to zonally restricted olfactory and vomeronasal neurons. J Neurosci 28(16):4271-82. [PubMed: 18417707] [MGI Ref ID J:134542]
Pappu R; Schwab SR; Cornelissen I; Pereira JP; Regard JB; Xu Y; Camerer E; Zheng YW; Huang Y; Cyster JG; Coughlin SR. 2007. Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science 316(5822):295-8. [PubMed: 17363629] [MGI Ref ID J:120783]
Parras CM; Hunt C; Sugimori M; Nakafuku M; Rowitch D; Guillemot F. 2007. The proneural gene Mash1 specifies an early population of telencephalic oligodendrocytes. J Neurosci 27(16):4233-42. [PubMed: 17442807] [MGI Ref ID J:121096]
Patel V; Li L; Cobo-Stark P; Shao X; Somlo S; Lin F; Igarashi P. 2008. Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia. Hum Mol Genet 17(11):1578-90. [PubMed: 18263895] [MGI Ref ID J:135523]
Phng LK; Potente M; Leslie JD; Babbage J; Nyqvist D; Lobov I; Ondr JK; Rao S; Lang RA; Thurston G; Gerhardt H. 2009. Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis. Dev Cell 16(1):70-82. [PubMed: 19154719] [MGI Ref ID J:144980]
Pilon N; Raiwet D; Viger RS; Silversides DW. 2008. Novel pre- and post-gastrulation expression of Gata4 within cells of the inner cell mass and migratory neural crest cells. Dev Dyn 237(4):1133-43. [PubMed: 18351674] [MGI Ref ID J:132976]
Potzner MR; Griffel C; Lutjen-Drecoll E; Bosl MR; Wegner M; Sock E. 2007. Prolonged Sox4 expression in oligodendrocytes interferes with normal myelination in the central nervous system. Mol Cell Biol 27(15):5316-26. [PubMed: 17515609] [MGI Ref ID J:123645]
Que J; Wilm B; Hasegawa H; Wang F; Bader D; Hogan BL. 2008. Mesothelium contributes to vascular smooth muscle and mesenchyme during lung development. Proc Natl Acad Sci U S A 105(43):16626-30. [PubMed: 18922767] [MGI Ref ID J:143278]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX11
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, these mice are bred as homozygotes. Mating System Homozygote x Homozygote (Female x Male) 08-SEP-06 Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $160.30 Female or Male Homozygous for Gt(ROSA)26Sortm1(EYFP)Cos
Pairs /Price (US dollars $) Pair Genotype $320.60 Homozygous for Gt(ROSA)26Sortm1(EYFP)Cos x Homozygous for Gt(ROSA)26Sortm1(EYFP)Cos
Additional Supply Details
| Pricing for International shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $208.40 Female or Male Homozygous for Gt(ROSA)26Sortm1(EYFP)Cos
Pairs /Price (US dollars $) Pair Genotype $416.80 Homozygous for Gt(ROSA)26Sortm1(EYFP)Cos x Homozygous for Gt(ROSA)26Sortm1(EYFP)Cos
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
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| Supply Notes |
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Control Information
| Control | ||
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| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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Tel: 1-800-422-6423 or 1-207-288-5845
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For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
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| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.