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Description
Strain Information
Type Congenic; Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote (Female x Male) 08-SEP-06 Species laboratory mouse Generation N6+F7 (05-JAN-09) Donating Investigator Frank Costantini, Columbia University Description
Mice that are homozygous for the mutant allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. These mice contain an Enhanced Yellow Fluorescent Protein gene (EYFP, Clonetech) inserted into the Gt(ROSA)26Sor locus. Expression of EYFP is blocked by an upstream loxP-flanked STOP sequence. When bred to mice with a cre recombinase gene under the control of a promoter of interest, the STOP sequence of the targeted gene is deleted in the tissue of interest, and EYFP expression is observed. These mutant mice may be useful in monitoring the Cre expression in living tissues, and tracing the lineage of such cells in embryos, young, and adult mice at desired time points.Mutant mice maintained on a genetic background containing a contribution from C57BL/6J have the potential to harbor a loss-of-function mutation in the nicotinamide (NAD) nucleotide transhydrogenase gene (Nnt, Chromosome 13). This Nnt mutation arose spontaneously in C57BL/6J sometime prior to 1984. It has been confirmed that this strain (Stock No. 006148) is homozygous for the Nnt mutant allele. For a more detailed description, please see the JAX Mice and Services article "Nnt Alleles in C57BL/6 Mice".
Development
A targeting vector was designed to contain the Enhanced Yellow Fluorescent Protein gene (from the pEYFP-N1 plasmid, Clonetech) downstream of a loxP-flanked stop sequence (neomycin resistance gene and a trimer of the SV40 polyadenylation sequence). This entire construct was inserted into the Gt(ROSA)26Sor locus via electroporation of 129X1/SvJ-derived JM-1 embryonic stem (ES) cells. Correctly targeted ES cells were microinjected in C57BL/6J blastocysts. Chimeric male Y8-8 was bred to a C57BL/6J female mouse. Mutant male progeny were backcrossed to C57BL/6J for 6 generations and then made homozygous prior to sending to The Jackson Laboratory. The Y chromosome may not be fixed to the C57BL/6 genetic background.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Fluorescent Protein Strains
View Fluorescent Protein Strains (225 strains)
005483 129-Tg(CAG-EYFP)7AC5Nagy/J 008299 B6.Cg-Tg(NEFL-EYFP/Nefh)40Gsn/J 007901 B6.Cg-Tg(Thy1-Brainbow1.0)HLich/J 007911 B6.Cg-Tg(Thy1-Brainbow1.1)MLich/J 007921 B6.Cg-Tg(Thy1-Brainbow2.1)RLich/J 007612 B6.Cg-Tg(Thy1-COP4/EYFP)18Gfng/J 007615 B6.Cg-Tg(Thy1-COP4/EYFP)9Gfng/J 005630 B6.Cg-Tg(Thy1-EYFP)15Jrs/J 003709 B6.Cg-Tg(Thy1-YFP)16Jrs/J 005627 B6.Cg-Tg(Thy1-YFP/Syp)10Jrs/J 003782 B6.Cg-Tg(Thy1-YFPH)2Jrs/J 007606 B6.Cg-Tg(Thy1-cre/ESR1,-EYFP)AGfng/J 008636 B6;C-Tg(Prnp-APP695*/EYFP)49Gsn/J 007910 B6;CBA-Tg(Thy1-Brainbow1.0)LLich/J 005620 B6;D2-Tg(S100B-EYFP)1Wjt/J 007610 B6;SJL-Tg(Thy1-cre/ESR1,-EYFP)VGfng/J 007880 B6SJL-Tg(Thy1-Stx1a/EYFP)1Sud/J 006618 C57BL/6-Tg(tetO-COX8A/EYFP)1Ksn/J 006362 C57BL/6J-Tg(CMV-Cox8a/EYFP)17J/J 007857 C57BL/6J-Tg(Eno2-YFP/Cox8a)YRwb/J 007860 C57BL/6J-Tg(Eno2-YFP/Cox8a)ZRwb/J 009422 NOD.Cg-Tg(Itgax-EYFP)1Mnz/QtngJ 005130 STOCK Gt(ROSA)26Sortm1(Smo/EYFP)Amc/J
Additional Web Information
Fluorescent Proteins/lacZ Systems
Introduction to Cre-lox technology
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
YFP relatedNeurobiology Research
Cre-lox System
loxP-flanked Sequences: Test/Reporter
Research Tools
Cre-lox System
loxP-flanked Sequences: Test/Reporter
Developmental Biology Research
Cre-lox System
Fluorescent Proteins
Research Tools
Fluorescent Proteins
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Gt(ROSA)26Sortm1(EYFP)Cos | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Frank Costantini | ||
| Allele Type | Targeted (Reporter) | ||
| Common Name(s) | R26-stop-EYFP; R26R EYFP; R26R-EYFP; R26RYFP; R26RYFP; ROSA26-LoxP-STOP-LoxP-EYFP; ROSA26-YFP; ROSA26-loxP-Stop-loxP-YF; ROSA26-stop-YFP reporter; ROSA26R-YFP; Rosa26-YFPfl; Rosa26YFPStop; Rosa26YFP; | ||
| Mutation Made By | Frank Costantini, Columbia University | ||
| Strain of Origin | 129X1/SvJ | ||
| ES Cell Line Name | JM-1 | ||
| ES Cell Line Strain | 129X1/SvJ | ||
| Site of Expression | when crossed to a cre recombinase-expressing strain, Enhanced Yellow Fluorescent Protein expression is observed in the cre-expressing tissues | ||
| Expressed Gene | YFP, Yellow Fluorescent Protein, jellyfish | ||
| Yellow Fluorescent Protein (YFP) is a derivative of Green Fluorescent Protein (GFP), a versatile reporter molecule which has found use in many biological applications. The original molecule has been modified in order to enhance fluorescence intensity and shift the wavelength emitted when excited. When YFP is utilized in a transgenic construct, tissue expressing sufficient amounts of YFP will fluoresce yellowish-green when exposed to a 513 nm light source. | |||
| Gene Symbol and Name | Gt(ROSA)26Sor, gene trap ROSA 26, Philippe Soriano | ||
| Chromosome | 6 | ||
| Gene Common Name(s) | AV258896; Gtrgeo26; Gtrosa26; R26; ROSA26; beta geo; expressed sequence AV258896; gene trap ROSA 26; gene trap ROSA b-geo 26; | ||
| Molecular Note | A construct containing a floxed PGK-neo cassette and an enhanced yellow fluorescent protein (EYFP) gene was inserted into the Gt(ROSA)26Sor locus via homologous recombination. The floxed neo cassette contains a strong tpA stop sequence which prevents thetranscription of EYFP. [MGI Ref ID J:80963] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Gt(Rosa)26Sortm1(EYFP)Cos, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References
Additional References
Gt(ROSA)26Sortm1(EYFP)Cos relatedAbou-Khalil R; Le Grand F; Pallafacchina G; Valable S; Authier FJ; Rudnicki MA; Gherardi RK; Germain S; Chretien F; Sotiropoulos A; Lafuste P; Montarras D; Chazaud B. 2009. Autocrine and paracrine angiopoietin 1/Tie-2 signaling promotes muscle satellite cell self-renewal. Cell Stem Cell 5(3):298-309. [PubMed: 19733541] [MGI Ref ID J:154124]
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Blank U; Brown A; Adams DC; Karolak MJ; Oxburgh L. 2009. BMP7 promotes proliferation of nephron progenitor cells via a JNK-dependent mechanism. Development 136(21):3557-66. [PubMed: 19793891] [MGI Ref ID J:153960]
Bonal C; Thorel F; Ait-Lounis A; Reith W; Trumpp A; Herrera PL. 2009. Pancreatic inactivation of c-Myc decreases acinar mass and transdifferentiates acinar cells into adipocytes in mice. Gastroenterology 136(1):309-319.e9. [PubMed: 19022256] [MGI Ref ID J:146087]
Bradley CK; Takano EA; Gothert JR; Gottgens B; Green AR; Begley CG; van Eekelen JA. 2007. Temporal regulation of Cre-recombinase activity in Scl-positive neurons of the central nervous system. Genesis 45(3):145-51. [PubMed: 17330263] [MGI Ref ID J:121708]
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Cai CL; Martin JC; Sun Y; Cui L; Wang L; Ouyang K; Yang L; Bu L; Liang X; Zhang X; Stallcup WB; Denton CP; McCulloch A; Chen J; Evans SM. 2008. A myocardial lineage derives from Tbx18 epicardial cells. Nature 454(7200):104-8. [PubMed: 18480752] [MGI Ref ID J:137459]
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Claret M; Smith MA; Batterham RL; Selman C; Choudhury AI; Fryer LG; Clements M; Al-Qassab H; Heffron H; Xu AW; Speakman JR; Barsh GS; Viollet B; Vaulont S; Ashford ML; Carling D; Withers DJ. 2007. AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. J Clin Invest 117(8):2325-36. [PubMed: 17671657] [MGI Ref ID J:123951]
Crone SA; Quinlan KA; Zagoraiou L; Droho S; Restrepo CE; Lundfald L; Endo T; Setlak J; Jessell TM; Kiehn O; Sharma K. 2008. Genetic ablation of V2a ipsilateral interneurons disrupts left-right locomotor coordination in mammalian spinal cord. Neuron 60(1):70-83. [PubMed: 18940589] [MGI Ref ID J:145621]
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Gromley A; Churchman ML; Zindy F; Sherr CJ. 2009. Transient expression of the Arf tumor suppressor during male germ cell and eye development in Arf-Cre reporter mice. Proc Natl Acad Sci U S A 106(15):6285-90. [PubMed: 19339492] [MGI Ref ID J:147752]
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Hwang CH; Simeone A; Lai E; Wu DK. 2009. Foxg1 is required for proper separation and formation of sensory cristae during inner ear development. Dev Dyn 238(11):2725-34. [PubMed: 19842177] [MGI Ref ID J:153730]
Ieda M ; Tsuchihashi T ; Ivey KN ; Ross RS ; Hong TT ; Shaw RM ; Srivastava D. 2009. Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling. Dev Cell 16(2):233-44. [PubMed: 19217425] [MGI Ref ID J:146619]
Johnson TA; Tsutsui S; Jirik FR. 2008. Antigen-induced pten gene deletion in T cells exacerbates neuropathology in experimental autoimmune encephalomyelitis. Am J Pathol 172(4):980-92. [PubMed: 18349128] [MGI Ref ID J:133344]
Kahn J; Shwartz Y; Blitz E; Krief S; Sharir A; Breitel DA; Rattenbach R; Relaix F; Maire P; Rountree RB; Kingsley DM; Zelzer E. 2009. Muscle contraction is necessary to maintain joint progenitor cell fate. Dev Cell 16(5):734-43. [PubMed: 19460349] [MGI Ref ID J:148688]
Kemp R; Ireland H; Clayton E; Houghton C; Howard L; Winton DJ. 2004. Elimination of background recombination: somatic induction of Cre by combined transcriptional regulation and hormone binding affinity. Nucleic Acids Res 32(11):e92. [PubMed: 15247325] [MGI Ref ID J:143936]
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Kim EJ; Leung CT; Reed RR; Johnson JE. 2007. In vivo analysis of Ascl1 defined progenitors reveals distinct developmental dynamics during adult neurogenesis and gliogenesis. J Neurosci 27(47):12764-74. [PubMed: 18032648] [MGI Ref ID J:127646]
Kim JK; Klinger M; Benjamin J; Xiao Y; Erle DJ; Littman DR; Killeen N. 2009. Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking. PLoS One 4(8):e6580. [PubMed: 19668367] [MGI Ref ID J:152472]
Klinger M; Kim JK; Chmura SA; Barczak A; Erle DJ; Killeen N. 2009. Thymic OX40 expression discriminates cells undergoing strong responses to selection ligands. J Immunol 182(8):4581-9. [PubMed: 19342632] [MGI Ref ID J:147746]
Kumar A; Lualdi M; Lewandoski M; Kuehn MR. 2008. Broad mesodermal and endodermal deletion of Nodal at postgastrulation stages results solely in left/right axial defects. Dev Dyn 237(12):3591-601. [PubMed: 18773491] [MGI Ref ID J:142430]
Kwon K; Hutter C; Sun Q; Bilic I; Cobaleda C; Malin S; Busslinger M. 2008. Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development. Immunity 28(6):751-62. [PubMed: 18538592] [MGI Ref ID J:137719]
Le Grand F; Jones AE; Seale V; Scime A; Rudnicki MA. 2009. Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells. Cell Stem Cell 4(6):535-47. [PubMed: 19497282] [MGI Ref ID J:149821]
Li L; Soetandyo N; Wang Q; Ye Y. 2009. The zinc finger protein A20 targets TRAF2 to the lysosomes for degradation. Biochim Biophys Acta 1793(2):346-53. [PubMed: 18952128] [MGI Ref ID J:147242]
Liston A; Farr AG; Chen Z; Benoist C; Mathis D; Manley NR; Rudensky AY. 2007. Lack of Foxp3 function and expression in the thymic epithelium. J Exp Med 204(3):475-80. [PubMed: 17353370] [MGI Ref ID J:125405]
Liu H; Schmidt-Supprian M; Shi Y; Hobeika E; Barteneva N; Jumaa H; Pelanda R; Reth M; Skok J; Rajewsky K; Shi Y. 2007. Yin Yang 1 is a critical regulator of B-cell development. Genes Dev 21(10):1179-89. [PubMed: 17504937] [MGI Ref ID J:121555]
Long JB; Jay SM; Segal SS; Madri JA. 2009. VEGF-A and Semaphorin3A: modulators of vascular sympathetic innervation. Dev Biol 334(1):119-32. [PubMed: 19631637] [MGI Ref ID J:153552]
Luche H; Weber O; Nageswara Rao T; Blum C; Fehling HJ. 2007. Faithful activation of an extra-bright red fluorescent protein in 'knock-in' Cre-reporter mice ideally suited for lineage tracing studies. Eur J Immunol 37(1):43-53. [PubMed: 17171761] [MGI Ref ID J:117041]
Luchman HA; Friedman HC; Villemaire ML; Peterson AC; Jirik FR. 2008. Temporally controlled prostate epithelium-specific gene alterations. Genesis 46(4):229-34. [PubMed: 18395839] [MGI Ref ID J:144541]
Lugus JJ; Park C; Ma YD; Choi K. 2009. Both primitive and definitive blood cells are derived from Flk-1+ mesoderm. Blood 113(3):563-6. [PubMed: 18957687] [MGI Ref ID J:144056]
Maatouk DM; Loveland KL; McManus MT; Moore K; Harfe BD. 2008. Dicer1 is required for differentiation of the mouse male germline. Biol Reprod 79(4):696-703. [PubMed: 18633141] [MGI Ref ID J:140872]
Malanchi I; Peinado H; Kassen D; Hussenet T; Metzger D; Chambon P; Huber M; Hohl D; Cano A; Birchmeier W; Huelsken J. 2008. Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling. Nature 452(7187):650-3. [PubMed: 18385740] [MGI Ref ID J:133779]
Marie JC; Liggitt D; Rudensky AY. 2006. Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity 25(3):441-54. [PubMed: 16973387] [MGI Ref ID J:113553]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX11
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, these mice are bred as homozygotes. Mating System Homozygote x Homozygote (Female x Male) 08-SEP-06 Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $160.30 Female or Male Homozygous for Gt(ROSA)26Sortm1(EYFP)Cos
Pairs /Price (US dollars $) Pair Genotype $320.60 Homozygous for Gt(ROSA)26Sortm1(EYFP)Cos x Homozygous for Gt(ROSA)26Sortm1(EYFP)Cos
Additional Supply Details
| Pricing for International shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $208.40 Female or Male Homozygous for Gt(ROSA)26Sortm1(EYFP)Cos
Pairs /Price (US dollars $) Pair Genotype $416.80 Homozygous for Gt(ROSA)26Sortm1(EYFP)Cos x Homozygous for Gt(ROSA)26Sortm1(EYFP)Cos
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
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The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.