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Product Information

Strain Details

Type Inbred Strain Additional information on Inbred Strains. Mating System Inbred x Inbred         (Female x Male) Species laboratory mouse Donating Investigator Dr. Jimmy Spearow,   University of California - Davis H2 Haplotype unknown Generation F36+1 (01-AUG-07)

Appearance
albino
Related Genotype: Tyr^c/Tyr^c

Strain Description
Swiss derived CD-1 mice are less responsive to exogenous estradiol than most inbred strains as measured by resistance to decreases in testes weight, spermatogenesis, and spermatid development. Derived from CD-1, the inbred strains CD3/JlsJ, CD7/JlsJ, and CD9/JlsJ mice exhibit a moderate sensitivity to endocrine disruption by estradiol, while CD10/JlsJ mice are highly resistant to endocrine disruption by estradiol. All lines generated in the selection program are significantly less responsive to estradiol than C57BL/6 mice.
The selectively bred strains CD3/JlsJ (006177), CD7/JlsJ (006178), CD9/JlsJ (006179) and CD10/Jls (006180) may serve as tools for mapping and characterizing genes responsible for estradiol sensitivity.

SNP data is available for this strain on the Wellcome Trust Centre for Human Genetics site.

Strain Development
This inbred strain was generated at the University of California-Davis as part of a selection program for hyposensitivity or hypersensitivity to exogenous 17-beta-estradiol (E2). All lines were derived from CD-1 mice. This strain reached the 36th generation of inbreeding in 2006. The Jackson Laboratory Repository imported four of these strains in 2006.

Colony Maintenance

Diet Information	LabDiet® 5K52/5K67

Related Strains

CD Strains

006180	CD10/JlsJ
006178	CD7/JlsJ
006179	CD9/JlsJ

View CD Strains     (3 strains)

Animal Health Reports

Room Number           AX11

Research Applications

This mouse can be used to support research in many areas including:

Research Tools
Reproductive Biology Research

References

Selected Reference(s)

Clemons KV; Spearow JL; Parmar R; Espiritu M; Stevens DA. 2004. Genetic susceptibility of mice to Candida albicans vaginitis correlates with host estrogen sensitivity. Infect Immun 72(8):4878-80. [PubMed: 15271952]  [MGI Ref ID J:107884]

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Price and Supply Information

Strain Name:	CD3/JlsJ
Stock Number:	006177

Price Details

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Supply Details

Standard Supply	Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes	Usually shipped between four and six weeks of age. This strain is included in the Mouse Mutant Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource.
Licensing	See General Terms and Conditions below

General Terms and Conditions

View JAX^® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering and Purchasing Information

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Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
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