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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Former Names FVB.Cg-Tg(tetO-cre)1Jaw/J (Changed: 21-MAR-08 ) Type Congenic; Mutant Stock; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System +/+ sibling x Hemizygote (Female x Male) 29-APR-08 Species laboratory mouse Generation F?+F4 (03-FEB-09) Donating Investigator Jeffrey Whitsett, Children's Hospital Medical Center Description
Hemizygous transgenic mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. These transgenic mice express Cre recombinase under the control of a tetracycline-responsive promoter element (TRE; tetO). When hemizygotes are bred with another transgenic mouse expressing either reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA) under the control of tissue-specific promoters, Cre recombinase expression and Cre-mediated recombination in the appropriate tissues of the bitransgenic offspring, can be regulated with the tetracycline analog, doxycycline. This strain represents an effective tool for generating inducible, tissue-specific-targeted mutants to study cell lineage during development.Importation of this model was supported by the Boomer Esiason Foundation.
Development
A transgenic construct containing the Cre recombinase gene under the control of the tetracycline-responsive promoter element (TRE; tetO), minimal CMV promoter and MT-1 polyadenylation site sequence was injected into mixed C57BL/6 and 129 background embryos. Founder mice were bred to FVB/N animals. A 27 SNP (single nucleotide polymorphism) panel analysis revealed that this strain is on a mixed STOCK background.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Tg(tetO-cre)1Jaw allele
006234 B6.Cg-Tg(tetO-cre)1Jaw/J 006244 C.Cg-Tg(tetO-cre)1Jaw/J 008244 FVB.Cg-Tg(tetO-cre)1Jaw/J View Strains carrying Tg(tetO-cre)1Jaw (3 strains)
Additional Web Information
Introduction to Cre-lox technology
Tet Expression Systems
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System
Cre Recombinase Expression: Germline/Embryonic Expression
Cre Recombinase Expression: Inducible
Genetics Research
Mutagenesis and Transgenesis: Tetop Tet System
Tet Expression Systems
tTA/rtTA Responsive Strains
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tg(tetO-cre)1Jaw | ||
|---|---|---|---|
| Allele Name | transgene insertion 1, Jeffrey A Whitsett | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | (tetO)7-CMV-Cre; (tetO)7-CMV-Cretg; (tetO)7-Cre; (tetO)7CMV-Cretg; (tetO)7CMVtg; TRECre; tetO-cre; | ||
| Mutation Made By | Andras Nagy, Mount Sinai Hospital | ||
| Strain of Origin | 129 and C57BL/6 | ||
| Site of Expression | widespread, inducible expression of Cre recombinase | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | tetO, tet operator, | ||
| Gene Symbol and Name | Tg(tetO-cre)1Jaw, transgene insertion 1, Jeffrey A Whitsett | ||
| Chromosome | UN | ||
| Gene Common Name(s) | (tetO)7-CMV-Cre; (tetO)7-CMV-Cretg; (tetO)7-Cre; (tetO)7CMV-Cretg; (tetO)7CMVtg; TRECre; tetO-cre; | ||
| Driver Note | tetO | ||
| Inducible Note | Induced by doxycycline | ||
| Molecular Note | The transgene is composed of 7 tetO sites, a minimal CMV promoter, and sequence encoding cre recombinase. [MGI Ref ID J:78365] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre Melt Curve Analysis, Melt Curve Analysis
Generic Cre, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Perl AK; Wert SE; Nagy A; Lobe CG; Whitsett JA. 2002. Early restriction of peripheral and proximal cell lineages during formation of the lung. Proc Natl Acad Sci U S A 99(16):10482-7. [PubMed: 12145322] [MGI Ref ID J:78365]
Additional References
Tg(tetO-cre)1Jaw relatedBasseres DS; Levantini E; Ji H; Monti S; Elf S; Dayaram T; Fenyus M; Kocher O; Golub T; Wong KK; Halmos B; Tenen DG. 2006. Respiratory failure due to differentiation arrest and expansion of alveolar cells following lung-specific loss of the transcription factor C/EBPalpha in mice. Mol Cell Biol 26(3):1109-23. [PubMed: 16428462] [MGI Ref ID J:105593]
Besnard V; Wert SE; Stahlman MT; Postle AD; Xu Y; Ikegami M; Whitsett JA. 2009. Deletion of Scap in alveolar type II cells influences lung lipid homeostasis and identifies a compensatory role for pulmonary lipofibroblasts. J Biol Chem 284(6):4018-30. [PubMed: 19074148] [MGI Ref ID J:147592]
Broide DH; Lawrence T; Doherty T; Cho JY; Miller M; McElwain K; McElwain S; Karin M. 2005. Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium. Proc Natl Acad Sci U S A 102(49):17723-8. [PubMed: 16317067] [MGI Ref ID J:104395]
Chen H; Zhuang F; Liu YH; Xu B; Del Moral P; Deng W; Chai Y; Kolb M; Gauldie J; Warburton D; Moses HL; Shi W. 2008. TGF-beta receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung. Eur Respir J 32(2):285-95. [PubMed: 18321928] [MGI Ref ID J:137996]
Dave V; Childs T; Xu Y; Ikegami M; Besnard V; Maeda Y; Wert SE; Neilson JR; Crabtree GR; Whitsett JA. 2006. Calcineurin/Nfat signaling is required for perinatal lung maturation and function. J Clin Invest 116(10):2597-609. [PubMed: 16998587] [MGI Ref ID J:114501]
Dave V; Wert SE; Tanner T; Thitoff AR; Loudy DE; Whitsett JA. 2008. Conditional deletion of Pten causes bronchiolar hyperplasia. Am J Respir Cell Mol Biol 38(3):337-45. [PubMed: 17921358] [MGI Ref ID J:146355]
Fong CH; Bebien M; Didierlaurent A; Nebauer R; Hussell T; Broide D; Karin M; Lawrence T. 2008. An antiinflammatory role for IKKbeta through the inhibition of 'classical' macrophage activation. J Exp Med 205(6):1269-76. [PubMed: 18490491] [MGI Ref ID J:137075]
Frank DU; Elliott SA; Park EJ; Hammond J; Saijoh Y; Moon AM. 2007. System for inducible expression of cre-recombinase from the Foxa2 locus in endoderm, notochord, and floor plate. Dev Dyn 236(4):1085-1092. [PubMed: 17304540] [MGI Ref ID J:119721]
Glaros S; Cirrincione GM; Palanca A; Metzger D; Reisman D. 2008. Targeted knockout of BRG1 potentiates lung cancer development. Cancer Res 68(10):3689-96. [PubMed: 18483251] [MGI Ref ID J:135031]
Hashimoto T; Bergen SE; Nguyen QL; Xu B; Monteggia LM; Pierri JN; Sun Z; Sampson AR; Lewis DA. 2005. Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia. J Neurosci 25(2):372-83. [PubMed: 15647480] [MGI Ref ID J:97675]
Hill JJ; Kolluri N; Hashimoto T; Wu Q; Sampson AR; Monteggia LM; Lewis DA. 2005. Analysis of pyramidal neuron morphology in an inducible knockout of brain-derived neurotrophic factor. Biol Psychiatry 57(8):932-4. [PubMed: 15820715] [MGI Ref ID J:102119]
Hokuto I; Ikegami M; Yoshida M; Takeda K; Akira S; Perl AK; Hull WM; Wert SE; Whitsett JA. 2004. Stat-3 is required for pulmonary homeostasis during hyperoxia. J Clin Invest 113(1):28-37. [PubMed: 14702106] [MGI Ref ID J:87622]
Kalin TV; Wang IC; Meliton L; Zhang Y; Wert SE; Ren X; Snyder J; Bell SM; Graf L Jr; Whitsett JA; Kalinichenko VV. 2008. Forkhead Box m1 transcription factor is required for perinatal lung function. Proc Natl Acad Sci U S A 105(49):19330-5. [PubMed: 19033457] [MGI Ref ID J:142246]
Kida H; Mucenski ML; Thitoff AR; Le Cras TD; Park KS; Ikegami M; Muller W; Whitsett JA. 2008. GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium. Am J Pathol 172(6):1542-54. [PubMed: 18467707] [MGI Ref ID J:136187]
Kim KK; Wei Y; Szekeres C; Kugler MC; Wolters PJ; Hill ML; Frank JA; Brumwell AN; Wheeler SE; Kreidberg JA; Chapman HA. 2009. Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest 119(1):213-24. [PubMed: 19104148] [MGI Ref ID J:144703]
Kuperman DA; Huang X; Nguyenvu L; Holscher C; Brombacher F; Erle DJ. 2005. IL-4 receptor signaling in Clara cells is required for allergen-induced mucus production. J Immunol 175(6):3746-52. [PubMed: 16148120] [MGI Ref ID J:116729]
Lin C; Yin Y; Chen H; Fisher AV; Chen F; Rauchman M; Ma L. 2009. Construction and characterization of a doxycycline-inducible transgenic system in Msx2 expressing cells. Genesis 47(5):352-359. [PubMed: 19370755] [MGI Ref ID J:148502]
Martis PC; Whitsett JA; Xu Y; Perl AK; Wan H; Ikegami M. 2006. C/EBP{alpha} is required for lung maturation at birth. Development 133(6):1155-64. [PubMed: 16467360] [MGI Ref ID J:106543]
Mason-Richie NA; Mistry MJ; Gettler CA; Elayyadi A; Wikenheiser-Brokamp KA. 2008. Retinoblastoma function is essential for establishing lung epithelial quiescence after injury. Cancer Res 68(11):4068-76. [PubMed: 18519665] [MGI Ref ID J:136426]
Matsuzaki Y; Besnard V; Clark JC; Xu Y; Wert SE; Ikegami M; Whitsett JA. 2008. STAT3 regulates ABCA3 expression and influences lamellar body formation in alveolar type II cells. Am J Respir Cell Mol Biol 38(5):551-8. [PubMed: 18096869] [MGI Ref ID J:149721]
Matsuzaki Y; Xu Y; Ikegami M; Besnard V; Park KS; Hull WM; Wert SE; Whitsett JA. 2006. Stat3 is required for cytoprotection of the respiratory epithelium during adenoviral infection. J Immunol 177(1):527-37. [PubMed: 16785550] [MGI Ref ID J:134441]
Miller LA; Wert SE; Clark JC; Xu Y; Perl AK; Whitsett JA. 2004. Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung. Dev Dyn 231(1):57-71. [PubMed: 15305287] [MGI Ref ID J:91723]
Monteggia LM; Barrot M; Powell CM; Berton O; Galanis V; Gemelli T; Meuth S; Nagy A; Greene RW; Nestler EJ. 2004. Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc Natl Acad Sci U S A 101(29):10827-32. [PubMed: 15249684] [MGI Ref ID J:91563]
Morimoto M; Kopan R. 2009. rtTA toxicity limits the usefulness of the SP-C-rtTA transgenic mouse. Dev Biol 325(1):171-8. [PubMed: 19013447] [MGI Ref ID J:143537]
Mucenski ML; Nation JM; Thitoff AR; Besnard V; Xu Y; Wert SE; Harada N; Taketo MM; Stahlman MT; Whitsett JA. 2005. Beta-catenin regulates differentiation of respiratory epithelial cells in vivo. Am J Physiol Lung Cell Mol Physiol 289(6):L971-9. [PubMed: 16040629] [MGI Ref ID J:105013]
Mucenski ML; Wert SE; Nation JM; Loudy DE; Huelsken J; Birchmeier W; Morrisey EE; Whitsett JA. 2003. beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis. J Biol Chem 278(41):40231-8. [PubMed: 12885771] [MGI Ref ID J:85946]
Nguyen NM; Kelley DG; Schlueter JA; Meyer MJ; Senior RM; Miner JH. 2005. Epithelial laminin alpha5 is necessary for distal epithelial cell maturation, VEGF production, and alveolization in the developing murine lung. Dev Biol 282(1):111-25. [PubMed: 15936333] [MGI Ref ID J:104565]
Opavsky R; Tsai SY; Guimond M; Arora A; Opavska J; Becknell B; Kaufmann M; Walton NA; Stephens JA; Fernandez SA; Muthusamy N; Felsher DW; Porcu P; Caligiuri MA; Leone G. 2007. Specific tumor suppressor function for E2F2 in Myc-induced T cell lymphomagenesis. Proc Natl Acad Sci U S A 104(39):15400-5. [PubMed: 17881568] [MGI Ref ID J:125304]
Opavsky R; Wang SH; Trikha P; Raval A; Huang Y; Wu YZ; Rodriguez B; Keller B; Liyanarachchi S; Wei G; Davuluri RV; Weinstein M; Felsher D; Ostrowski M; Leone G; Plass C. 2007. CpG island methylation in a mouse model of lymphoma is driven by the genetic configuration of tumor cells. PLoS Genet 3(9):1757-69. [PubMed: 17907813] [MGI Ref ID J:130029]
Park KS; Wells JM; Zorn AM; Wert SE; Laubach VE; Fernandez LG; Whitsett JA. 2006. Transdifferentiation of ciliated cells during repair of the respiratory epithelium. Am J Respir Cell Mol Biol 34(2):151-7. [PubMed: 16239640] [MGI Ref ID J:120191]
Perl AK; Kist R; Shan Z; Scherer G; Whitsett JA. 2005. Normal lung development and function after Sox9 inactivation in the respiratory epithelium. Genesis 41(1):23-32. [PubMed: 15645446] [MGI Ref ID J:95910]
Perl AK; Wert SE; Loudy DE; Shan Z; Blair PA; Whitsett JA. 2005. Conditional recombination reveals distinct subsets of epithelial cells in trachea, bronchi, and alveoli. Am J Respir Cell Mol Biol 33(5):455-62. [PubMed: 16055670] [MGI Ref ID J:132772]
Quinton LJ; Jones MR; Robson BE; Simms BT; Whitsett JA; Mizgerd JP. 2008. Alveolar epithelial STAT3, IL-6 family cytokines, and host defense during Escherichia coli pneumonia. Am J Respir Cell Mol Biol 38(6):699-706. [PubMed: 18192501] [MGI Ref ID J:149718]
Saini Y; Harkema JR; LaPres JJ. 2008. HIF1alpha is essential for normal intrauterine differentiation of alveolar epithelium and surfactant production in the newborn lung of mice. J Biol Chem 283(48):33650-7. [PubMed: 18801745] [MGI Ref ID J:143384]
Shaw AT; Meissner A; Dowdle JA; Crowley D; Magendantz M; Ouyang C; Parisi T; Rajagopal J; Blank LJ; Bronson RT; Stone JR; Tuveson DA; Jaenisch R; Jacks T. 2007. Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. Genes Dev 21(6):694-707. [PubMed: 17369402] [MGI Ref ID J:119477]
Shu W; Guttentag S; Wang Z; Andl T; Ballard P; Lu MM; Piccolo S; Birchmeier W; Whitsett JA; Millar SE; Morrisey EE. 2005. Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung. Dev Biol 283(1):226-39. [PubMed: 15907834] [MGI Ref ID J:99391]
Sun J; Chen H; Chen C; Whitsett JA; Mishina Y; Bringas P Jr; Ma JC; Warburton D; Shi W. 2008. Prenatal lung epithelial cell-specific abrogation of alk3-bone morphogenetic protein signaling causes neonatal respiratory distress by disrupting distal airway formation. Am J Pathol 172(3):571-82. [PubMed: 18258849] [MGI Ref ID J:132011]
Tian Y; Zhou R; Rehg JE; Jackowski S. 2007. Role of phosphocholine cytidylyltransferase alpha in lung development. Mol Cell Biol 27(3):975-82. [PubMed: 17130238] [MGI Ref ID J:118292]
Wan H; Dingle S; Xu Y; Besnard V; Kaestner KH; Ang SL; Wert S; Stahlman MT; Whitsett JA. 2005. Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis. J Biol Chem 280(14):13809-16. [PubMed: 15668254] [MGI Ref ID J:98750]
Wan H; Kaestner KH; Ang SL; Ikegami M; Finkelman FD; Stahlman MT; Fulkerson PC; Rothenberg ME; Whitsett JA. 2004. Foxa2 regulates alveolarization and goblet cell hyperplasia. Development 131(4):953-64. [PubMed: 14757645] [MGI Ref ID J:88601]
Wan H; Luo F; Wert SE; Zhang L; Xu Y; Ikegami M; Maeda Y; Bell SM; Whitsett JA. 2008. Kruppel-like factor 5 is required for perinatal lung morphogenesis and function. Development 135(15):2563-72. [PubMed: 18599506] [MGI Ref ID J:138576]
Wang IC; Meliton L; Ren X; Zhang Y; Balli D; Snyder J; Whitsett JA; Kalinichenko VV; Kalin TV. 2009. Deletion of Forkhead Box M1 transcription factor from respiratory epithelial cells inhibits pulmonary tumorigenesis. PLoS One 4(8):e6609. [PubMed: 19672312] [MGI Ref ID J:152467]
Weng Y; Fang C; Turesky RJ; Behr M; Kaminsky LS; Ding X. 2007. Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice. Cancer Res 67(16):7825-32. [PubMed: 17699788] [MGI Ref ID J:124316]
Wikenheiser-Brokamp KA. 2004. Rb family proteins differentially regulate distinct cell lineages during epithelial development. Development 131(17):4299-310. [PubMed: 15294860] [MGI Ref ID J:92049]
Yu TS; Dandekar M; Monteggia LM; Parada LF; Kernie SG. 2005. Temporally regulated expression of Cre recombinase in neural stem cells. Genesis 41(4):147-53. [PubMed: 15789426] [MGI Ref ID J:97312]
Zhang Y; Andl T; Yang SH; Teta M; Liu F; Seykora JT; Tobias JW; Piccolo S; Schmidt-Ullrich R; Nagy A; Taketo MM; Dlugosz AA; Millar SE. 2008. Activation of {beta}-catenin signaling programs embryonic epidermis to hair follicle fate. Development 135(12):2161-72. [PubMed: 18480165] [MGI Ref ID J:136961]
Zhang Y; Goss AM; Cohen ED; Kadzik R; Lepore JJ; Muthukumaraswamy K; Yang J; DeMayo FJ; Whitsett JA; Parmacek MS; Morrisey EE. 2008. A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration. Nat Genet 40(7):862-70. [PubMed: 18536717] [MGI Ref ID J:138407]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX11
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, hemizygous mice are bred to wildtype siblings. Mating System +/+ sibling x Hemizygote (Female x Male) 29-APR-08 Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $243.50 Female or Male Hemizygous for Tg(tetO-cre)1Jaw
Pairs /Price (US dollars $) Pair Genotype $297.85 Hemizygous for Tg(tetO-cre)1Jaw x Noncarrier $297.85 Noncarrier x Hemizygous for Tg(tetO-cre)1Jaw
Additional Supply Details
| Pricing for International shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $316.60 Female or Male Hemizygous for Tg(tetO-cre)1Jaw
Pairs /Price (US dollars $) Pair Genotype $387.30 Hemizygous for Tg(tetO-cre)1Jaw x Noncarrier $387.30 Noncarrier x Hemizygous for Tg(tetO-cre)1Jaw
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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General Terms and Conditions
Use of the Tet-System may require a license, see Licenses for Strains Using TET-System Technology.
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