Strain Name:

FVB.Cg-Tg(SFTPC-rtTA)5Jaw/J

Stock Number:

006225

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Availability:

Cryopreserved - Ready for recovery

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names STOCK Tg(SFTPC-rtTA)5Jaw/J    (Changed: 19-FEB-07 )
Type Congenic; Mutant Stock; Mutant Strain; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
Generation?+N1F2pN1
Generation Definitions
 
Donating InvestigatorDr. Jeffrey Whitsett,   Children's Hospital Medical Center

Description
Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. The donating investigator reports that homozygous transgenic mice are not viable. These transgenic mice express the reverse tetracycline-controlled transactivator (rtTA) protein under the control of the human SFTPC, surfactant, pulmonary-associated protein C, promoter. rtTA activity is detected in lung peripheral epithelial cells from adult mice and in embryos from pregnant females treated with the tetracycline analog doxycycline (dox). In the latter, rtTA-induced expression of a luciferase reporter under the regulation of a tetracycline-responsive promoter (TRE; tetO) has been detected as early as embryonic day 10.5. When hemizygotes are mated to a second transgenic strain carrying a gene of interest under the regulatory control of a TRE, expression of the target gene in the bitransgenic offspring can be regulated by dox; in the presence of dox, transcription of the target gene is induced in cells where rtTA is expressed. This strain provides a "Tet-On" tool that allows the inducible expression of genes in the developing and adult lung and respiratory epithelium. Please note that some level of rtTA expression may be present in lung tissue from mice untreated with dox.

Importation of this model was supported by the Boomer Esiason Foundation.

Development
A transgenic construct containing 3.7kb sequence of the human SFTPC, surfactant, pulmonary-associated protein C, gene promoter, the reverse tetracycline regulatable transactivator protein (rtTA) gene, and SV40 polyadenylation signal sequence was injected into C57BL/6 X 129 embryos. Founder mice were bred to FVB/N animals for at least 10 generations by the donating investigator.

Control Information

  Control
   Noncarrier
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Tg(SFTPC-rtTA)5Jaw allele
006235   B6.Cg-Tg(SFTPC-rtTA)5Jaw/J
006245   C.Cg-Tg(SFTPC-rtTA)5Jaw/J
View Strains carrying   Tg(SFTPC-rtTA)5Jaw     (2 strains)

Strains carrying other alleles of SFTPC
016146   STOCK Tg(SFTPC-rtTA)2Jaw/J
View Strains carrying other alleles of SFTPC     (1 strain)

Strains carrying other alleles of rtTA
016567   129S.Cg-Tg(Hoxb7-rtTA*M2)2Cos/J
017983   B6.Cg-Col1a1tm9(tetO-Dnmt3b_i1)Jae Gt(ROSA)26Sortm1(rtTA*M2)Jae/J
014588   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm6(tetO-MSI2)Jae/J
014602   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-mCherry)Eggn/J
023749   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Tg(tetO-Pou5f1,-Sox2,-Klf4,-Myc)1Srn/J
006965   B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae/J
005670   B6.Cg-Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J
016997   B6.Cg-Tg(Axin2-rtTA2S*M2)7Cos/J
012418   B6.Cg-Tg(CD68-rtTA2S*M2)3Mpil/Mmjax
014098   B6.Cg-Tg(GFAP-rtTA*M2)1Rmra/J
007176   B6.Cg-Tg(Pax8-rtTA2S*M2)1Koes/J
006232   B6.Cg-Tg(Scgb1a1-rtTA)1Jaw/J
021025   B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-cre)Haho/J
006911   B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm2(tetO-Pou5f1)Jae/J
016836   B6;129S4-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm7(tetO-HIST1H2BJ/GFP)Jae/J
012433   B6;C3-Tg(ACTA1-rtTA,tetO-cre)102Monk/J
021187   B6;FVB-Tg(Pbsn-rtTA*M2)42Xy/J
010574   B6;SJL-Tg(Gh1-rtTA)4-3Jek/J
007678   B6;SJL-Tg(KRT14-rtTA)208Jek/J
010576   B6;SJL-Tg(MMTV-rtTA)4-1Jek/J
010549   B6N.Cg-Tg(Prkcd-glc-1-rtTA)2And/J
016532   B6N.FVB(Cg)-Tg(CAG-rtTA3)4288Slowe/J
006242   C.Cg-Tg(Scgb1a1-rtTA)1Jaw/J
017955   C57BL/6-Tg(Gfap-rtTA,tetO-MAOB,-lacZ)1Jkan/J
008099   FVB-Tg(KRT14-rtTA)F42Efu/J
004127   FVB-Tg(Nes-rtTA)306Rvs/J
008326   FVB-Tg(Pomc-rtTA)1Rck/J
006222   FVB.Cg-Tg(Scgb1a1-rtTA)1Jaw/J
008202   FVB/N-Tg(NPHS2-rtTA2*M2)1Jbk/J
006875   FVB/N-Tg(Tagln-rtTA)E1Jwst/J
004602   NOD.Cg-Tg(Ins2-rtTA)2Doi/DoiJ
005734   NOD/Lt-Tg(Ins2-rtTA)1Ach/AchJ
011004   STOCK Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae/J
011011   STOCK Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm4(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae/J
011013   STOCK Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm5(tetO-Pou5f1,-Klf4,-Myc)Jae/J
005572   STOCK Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J
016116   STOCK Waptm2(rtTA)Kuw/J
003273   STOCK Tg(CMV-rtTA)4Bjd/J
018156   STOCK Tg(Drd1a-rtTA)ARgmk/J
019110   STOCK Tg(Hoxb7-rtTA*M2)RS40BCos/Mmjax
008755   STOCK Tg(Ins2-rtTA)2Efr Tg(teto-DTA)1Gfi/J
008250   STOCK Tg(Ins2-rtTA)2Efr/J
017519   STOCK Tg(KRT5-rtTA)T2D6Sgkd/J
016146   STOCK Tg(SFTPC-rtTA)2Jaw/J
016145   STOCK Tg(Scgb1a1-rtTA)2Jaw/J
005493   STOCK Tg(Tek-rtTA,TRE-lacZ)1425Tpr/J
View Strains carrying other alleles of rtTA     (46 strains)

Additional Web Information

Tet Expression Systems

Phenotype

Phenotype Information

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Research Applications
This mouse can be used to support research in many areas including:

Developmental Biology Research
Internal/Organ Defects
      lung

Immunology, Inflammation and Autoimmunity Research
Cystic Fibrosis

Internal/Organ Research
Lung Defects

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      Tetop Tet System
Developmental Biology Research
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      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Tetop Tet System
Immunology, Inflammation and Autoimmunity Research
Internal/Organ Research
Tet Expression Systems
      tTA/rtTA Expressing Strains

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tg(SFTPC-rtTA)5Jaw
Allele Name transgene insertion 5, Jeffrey A Whitsett
Allele Type Transgenic (Inserted expressed sequence)
Common Name(s) SFTPC-rtTA; SP-C-rtTA mice (Line 1); SP-C-rtTAtg; SP-CrtTA; SP-CrtTAtg; SPC-rtTA; Sp-c-rtta; Tg(SFTPC-rtTA)1Jaw; hSPC-rtTA+;
Mutation Made ByDr. Jeffrey Whitsett,   Children's Hospital Medical Center
Site of ExpressionExpresses rtTA in developing and adult lung.
Expressed Gene rtTA, reverse tetracycline-controlled transactivator, E. coli
The tetracycline repressor gene (Tetr), arose from chemically mutated Escherichia coli genome which was screened for tetracycline dependence (Gossen and Bujard, 1992). One mutant with a four amino acid residue change (rTetR) exhibited dependence on tetracycline for induction of the targeted gene and was used in the rtTA construct (Gossen et al, 1995). rTetr was fused at the C-terminus with the viral co-activator, virion protein 16 of the herpes simplex virus (VP-16).
Promoter SFTPC, surfactant protein C, human
Molecular Note The transgene is composed of 3.7 kb of human SFTPC promoter, a reverse tetracycline responsive transactivator gene (rt-TA), and a 0.45 kb SV40 polyadenylation signal. Transgene expression was confirmed by RT-PCR analysis. The human SFTPC promoter is active in respiratory epithelial cells. [MGI Ref ID J:61736]
 
 

Genotyping

Genotyping Information

Genotyping Protocols

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References

References provided by MGI

Selected Reference(s)

Tichelaar JW; Lu W; Whitsett JA. 2000. Conditional expression of fibroblast growth factor-7 in the developing and mature lung. J Biol Chem 275(16):11858-64. [PubMed: 10766812]  [MGI Ref ID J:61736]

Additional References

Tg(SFTPC-rtTA)5Jaw related

Akeson AL; Greenberg JM; Cameron JE; Thompson FY; Brooks SK; Wiginton D; Whitsett JA. 2003. Temporal and spatial regulation of VEGF-A controls vascular patterning in the embryonic lung. Dev Biol 264(2):443-55. [PubMed: 14651929]  [MGI Ref ID J:86840]

Allen TD; Zhu CQ; Jones KD; Yanagawa N; Tsao MS; Bishop JM. 2011. Interaction between MYC and MCL1 in the Genesis and Outcome of Non-Small-Cell Lung Cancer. Cancer Res 71(6):2212-21. [PubMed: 21406400]  [MGI Ref ID J:169920]

Antony N; Weir JR; McDougall AR; Mantamadiotis T; Meikle PJ; Cole TJ; Bird AD. 2013. cAMP response element binding protein1 is essential for activation of steroyl co-enzyme a desaturase 1 (Scd1) in mouse lung type II epithelial cells. PLoS One 8(4):e59763. [PubMed: 23637738]  [MGI Ref ID J:200565]

Balli D; Ustiyan V; Zhang Y; Wang IC; Masino AJ; Ren X; Whitsett JA; Kalinichenko VV; Kalin TV. 2013. Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition. EMBO J 32(2):231-44. [PubMed: 23288041]  [MGI Ref ID J:193263]

Basseres DS; Levantini E; Ji H; Monti S; Elf S; Dayaram T; Fenyus M; Kocher O; Golub T; Wong KK; Halmos B; Tenen DG. 2006. Respiratory failure due to differentiation arrest and expansion of alveolar cells following lung-specific loss of the transcription factor C/EBPalpha in mice. Mol Cell Biol 26(3):1109-23. [PubMed: 16428462]  [MGI Ref ID J:105593]

Bridges JP; Lin S; Ikegami M; Shannon JM. 2012. Conditional hypoxia inducible factor-1alpha induction in embryonic pulmonary epithelium impairs maturation and augments lymphangiogenesis. Dev Biol 362(1):24-41. [PubMed: 22094019]  [MGI Ref ID J:180152]

Calvi C; Podowski M; Lopez-Mercado A; Metzger S; Misono K; Malinina A; Dikeman D; Poonyagariyon H; Ynalvez L; Derakhshandeh R; Le A; Merchant M; Schwall R; Neptune ER. 2013. Hepatocyte growth factor, a determinant of airspace homeostasis in the murine lung. PLoS Genet 9(2):e1003228. [PubMed: 23459311]  [MGI Ref ID J:195194]

Ceteci F; Ceteci S; Karreman C; Kramer BW; Asan E; Gotz R; Rapp UR. 2007. Disruption of Tumor Cell Adhesion Promotes Angiogenic Switch and Progression to Micrometastasis in RAF-Driven Murine Lung Cancer. Cancer Cell 12(2):145-159. [PubMed: 17692806]  [MGI Ref ID J:124321]

Chapman HA; Li X; Alexander JP; Brumwell A; Lorizio W; Tan K; Sonnenberg A; Wei Y; Vu TH. 2011. Integrin alpha6beta4 identifies an adult distal lung epithelial population with regenerative potential in mice. J Clin Invest 121(7):2855-62. [PubMed: 21701069]  [MGI Ref ID J:175915]

Chen G; Wan H; Luo F; Zhang L; Xu Y; Lewkowich I; Wills-Karp M; Whitsett JA. 2010. Foxa2 programs Th2 cell-mediated innate immunity in the developing lung. J Immunol 184(11):6133-41. [PubMed: 20483781]  [MGI Ref ID J:161217]

Chen H; Zhuang F; Liu YH; Xu B; Del Moral P; Deng W; Chai Y; Kolb M; Gauldie J; Warburton D; Moses HL; Shi W. 2008. TGF-beta receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung. Eur Respir J 32(2):285-95. [PubMed: 18321928]  [MGI Ref ID J:137996]

Chen L; Acciani T; Le Cras T; Lutzko C; Perl AK. 2012. Dynamic regulation of platelet-derived growth factor receptor alpha expression in alveolar fibroblasts during realveolarization. Am J Respir Cell Mol Biol 47(4):517-27. [PubMed: 22652199]  [MGI Ref ID J:201241]

Clark JC; Tichelaar JW; Wert SE; Itoh N; Perl AK; Stahlman MT; Whitsett JA. 2001. FGF-10 disrupts lung morphogenesis and causes pulmonary adenomas in vivo. Am J Physiol Lung Cell Mol Physiol 280(4):L705-15. [PubMed: 11238011]  [MGI Ref ID J:68525]

Dave V; Childs T; Xu Y; Ikegami M; Besnard V; Maeda Y; Wert SE; Neilson JR; Crabtree GR; Whitsett JA. 2006. Calcineurin/Nfat signaling is required for perinatal lung maturation and function. J Clin Invest 116(10):2597-609. [PubMed: 16998587]  [MGI Ref ID J:114501]

Dave V; Wert SE; Tanner T; Thitoff AR; Loudy DE; Whitsett JA. 2008. Conditional deletion of Pten causes bronchiolar hyperplasia. Am J Respir Cell Mol Biol 38(3):337-45. [PubMed: 17921358]  [MGI Ref ID J:146355]

Ding BS; Nolan DJ; Guo P; Babazadeh AO; Cao Z; Rosenwaks Z; Crystal RG; Simons M; Sato TN; Worgall S; Shido K; Rabbany SY; Rafii S. 2011. Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization. Cell 147(3):539-53. [PubMed: 22036563]  [MGI Ref ID J:178690]

Eckle T; Brodsky K; Bonney M; Packard T; Han J; Borchers CH; Mariani TJ; Kominsky DJ; Mittelbronn M; Eltzschig HK. 2013. HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium. PLoS Biol 11(9):e1001665. [PubMed: 24086109]  [MGI Ref ID J:201805]

Eckle T; Kewley EM; Brodsky KS; Tak E; Bonney S; Gobel M; Anderson D; Glover LE; Riegel AK; Colgan SP; Eltzschig HK. 2014. Identification of hypoxia-inducible factor HIF-1A as transcriptional regulator of the A2B adenosine receptor during acute lung injury. J Immunol 192(3):1249-56. [PubMed: 24391213]  [MGI Ref ID J:207297]

El-Hashash AH; Al Alam D; Turcatel G; Bellusci S; Warburton D. 2011. Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol 350(1):112-26. [PubMed: 21129374]  [MGI Ref ID J:170236]

El-Hashash AH; Turcatel G; Al Alam D; Buckley S; Tokumitsu H; Bellusci S; Warburton D. 2011. Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium. Development 138(7):1395-407. [PubMed: 21385765]  [MGI Ref ID J:171504]

El-Hashash AH; Turcatel G; Varma S; Berika M; Al Alam D; Warburton D. 2012. Eya1 protein phosphatase regulates tight junction formation in lung distal epithelium. J Cell Sci 125(Pt 17):4036-48. [PubMed: 22685326]  [MGI Ref ID J:198889]

Floyd HS; Farnsworth CL; Kock ND; Mizesko MC; Little JL; Dance ST; Everitt J; Tichelaar J; Whitsett JA; Miller MS. 2005. Conditional expression of the mutant Ki-rasG12C allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model. Carcinogenesis 26(12):2196-206. [PubMed: 16051643]  [MGI Ref ID J:102839]

Goncharova EA; Goncharov DA; James ML; Atochina-Vasserman EN; Stepanova V; Hong SB; Li H; Gonzales L; Baba M; Linehan WM; Gow AJ; Margulies S; Guttentag S; Schmidt LS; Krymskaya VP. 2014. Folliculin controls lung alveolar enlargement and epithelial cell survival through E-cadherin, LKB1, and AMPK. Cell Rep 7(2):412-23. [PubMed: 24726356]  [MGI Ref ID J:211817]

Gontan C; de Munck A; Vermeij M; Grosveld F; Tibboel D; Rottier R. 2008. Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation. Dev Biol 317(1):296-309. [PubMed: 18374910]  [MGI Ref ID J:136180]

Greenwood KK; Proper SP; Saini Y; Bramble LA; Jackson-Humbles DN; Wagner JG; Harkema JR; LaPres JJ. 2012. Neonatal epithelial hypoxia inducible factor-1alpha expression regulates the response of the lung to experimental asthma. Am J Physiol Lung Cell Mol Physiol 302(5):L455-62. [PubMed: 22180657]  [MGI Ref ID J:183445]

Gupte VV; Ramasamy SK; Reddy R; Lee J; Weinreb PH; Violette SM; Guenther A; Warburton D; Driscoll B; Minoo P; Bellusci S. 2009. Overexpression of fibroblast growth factor-10 during both inflammatory and fibrotic phases attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Respir Crit Care Med 180(5):424-36. [PubMed: 19498056]  [MGI Ref ID J:167964]

Hokuto I; Ikegami M; Yoshida M; Takeda K; Akira S; Perl AK; Hull WM; Wert SE; Whitsett JA. 2004. Stat-3 is required for pulmonary homeostasis during hyperoxia. J Clin Invest 113(1):28-37. [PubMed: 14702106]  [MGI Ref ID J:87622]

Huang Y; Kempen MB; Munck AB; Swagemakers S; Driegen S; Mahavadi P; Meijer D; van Ijcken W; van der Spek P; Grosveld F; Gunther A; Tibboel D; Rottier RJ. 2012. Hypoxia-inducible factor 2alpha plays a critical role in the formation of alveoli and surfactant. Am J Respir Cell Mol Biol 46(2):224-32. [PubMed: 22298531]  [MGI Ref ID J:191907]

Ihara S; Kida H; Arase H; Tripathi LP; Chen YA; Kimura T; Yoshida M; Kashiwa Y; Hirata H; Fukamizu R; Inoue R; Hasegawa K; Goya S; Takahashi R; Minami T; Tsujino K; Suzuki M; Kohmo S; Inoue K; Nagatomo I; Takeda Y; Kijima T; Mizuguchi K; Tachibana I; Kumanogoh A. 2012. Inhibitory roles of signal transducer and activator of transcription 3 in antitumor immunity during carcinogen-induced lung tumorigenesis. Cancer Res 72(12):2990-9. [PubMed: 22659452]  [MGI Ref ID J:189293]

Ikeda H; Shiojima I; Oka T; Yoshida M; Maemura K; Walsh K; Igarashi T; Komuro I. 2011. Increased Akt-mTOR Signaling in Lung Epithelium Is Associated with Respiratory Distress Syndrome in Mice. Mol Cell Biol 31(5):1054-65. [PubMed: 21189286]  [MGI Ref ID J:169183]

Ikegami M; Falcone A; Whitsett JA. 2008. STAT-3 regulates surfactant phospholipid homeostasis in normal lung and during endotoxin-mediated lung injury. J Appl Physiol 104(6):1753-60. [PubMed: 18369093]  [MGI Ref ID J:183960]

Inoshima I; Inoshima N; Wilke GA; Powers ME; Frank KM; Wang Y; Bubeck Wardenburg J. 2011. A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice. Nat Med 17(10):1310-4. [PubMed: 21926978]  [MGI Ref ID J:177286]

Kalin TV; Wang IC; Meliton L; Zhang Y; Wert SE; Ren X; Snyder J; Bell SM; Graf L Jr; Whitsett JA; Kalinichenko VV. 2008. Forkhead Box m1 transcription factor is required for perinatal lung function. Proc Natl Acad Sci U S A 105(49):19330-5. [PubMed: 19033457]  [MGI Ref ID J:142246]

Kida H; Mucenski ML; Thitoff AR; Le Cras TD; Park KS; Ikegami M; Muller W; Whitsett JA. 2008. GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium. Am J Pathol 172(6):1542-54. [PubMed: 18467707]  [MGI Ref ID J:136187]

Kim KK; Wei Y; Szekeres C; Kugler MC; Wolters PJ; Hill ML; Frank JA; Brumwell AN; Wheeler SE; Kreidberg JA; Chapman HA. 2009. Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest 119(1):213-24. [PubMed: 19104148]  [MGI Ref ID J:144703]

Kimura T; Kawabe H; Jiang C; Zhang W; Xiang YY; Lu C; Salter MW; Brose N; Lu WY; Rotin D. 2011. Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease. Proc Natl Acad Sci U S A 108(8):3216-21. [PubMed: 21300902]  [MGI Ref ID J:169296]

Kulkarni RM; Greenberg JM; Akeson AL. 2009. NFATc1 regulates lymphatic endothelial development. Mech Dev 126(5-6):350-65. [PubMed: 19233265]  [MGI Ref ID J:149253]

Kulkarni RM; Herman A; Ikegami M; Greenberg JM; Akeson AL. 2011. Lymphatic ontogeny and effect of hypoplasia in developing lung. Mech Dev 128(1-2):29-40. [PubMed: 20932899]  [MGI Ref ID J:170175]

Lawson WE; Cheng DS; Degryse AL; Tanjore H; Polosukhin VV; Xu XC; Newcomb DC; Jones BR; Roldan J; Lane KB; Morrisey EE; Beers MF; Yull FE; Blackwell TS. 2011. Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs. Proc Natl Acad Sci U S A 108(26):10562-7. [PubMed: 21670280]  [MGI Ref ID J:173548]

Lin S; Ikegami M; Xu Y; Bosserhoff AK; Malkinson AM; Shannon JM. 2008. Misexpression of MIA disrupts lung morphogenesis and causes neonatal death. Dev Biol 316(2):441-55. [PubMed: 18342301]  [MGI Ref ID J:135990]

Liu Y; Sadikot RT; Adami GR; Kalinichenko VV; Pendyala S; Natarajan V; Zhao YY; Malik AB. 2011. FoxM1 mediates the progenitor function of type II epithelial cells in repairing alveolar injury induced by Pseudomonas aeruginosa. J Exp Med 208(7):1473-84. [PubMed: 21708928]  [MGI Ref ID J:176807]

Lu K; Reddy R; Berika M; Warburton D; El-Hashash AH. 2013. Abrogation of Eya1/Six1 disrupts the saccular phase of lung morphogenesis and causes remodeling. Dev Biol 382(1):110-23. [PubMed: 23895934]  [MGI Ref ID J:202226]

Mallory BP; Mead TJ; Wiginton DA; Kulkarni RM; Greenberg JM; Akeson AL. 2006. Lymphangiogenesis in the developing lung promoted by VEGF-A. Microvasc Res 72(1-2):62-73. [PubMed: 16806288]  [MGI Ref ID J:129289]

Martis PC; Whitsett JA; Xu Y; Perl AK; Wan H; Ikegami M. 2006. C/EBP{alpha} is required for lung maturation at birth. Development 133(6):1155-64. [PubMed: 16467360]  [MGI Ref ID J:106543]

Matsuzaki Y; Besnard V; Clark JC; Xu Y; Wert SE; Ikegami M; Whitsett JA. 2008. STAT3 regulates ABCA3 expression and influences lamellar body formation in alveolar type II cells. Am J Respir Cell Mol Biol 38(5):551-8. [PubMed: 18096869]  [MGI Ref ID J:149721]

Matsuzaki Y; Xu Y; Ikegami M; Besnard V; Park KS; Hull WM; Wert SE; Whitsett JA. 2006. Stat3 is required for cytoprotection of the respiratory epithelium during adenoviral infection. J Immunol 177(1):527-37. [PubMed: 16785550]  [MGI Ref ID J:134441]

Melino G. 2011. p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53. Cell Death Differ 18(9):1487-99. [PubMed: 21760596]  [MGI Ref ID J:203617]

Metzger DE; Stahlman MT; Shannon JM. 2008. Misexpression of ELF5 disrupts lung branching and inhibits epithelial differentiation. Dev Biol 320(1):149-60. [PubMed: 18544451]  [MGI Ref ID J:139210]

Miller LA; Wert SE; Clark JC; Xu Y; Perl AK; Whitsett JA. 2004. Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung. Dev Dyn 231(1):57-71. [PubMed: 15305287]  [MGI Ref ID J:91723]

Minowada G; Miller YE. 2009. Overexpression of Sprouty 2 in mouse lung epithelium inhibits urethane-induced tumorigenesis. Am J Respir Cell Mol Biol 40(1):31-7. [PubMed: 18635814]  [MGI Ref ID J:155786]

Morimoto M; Kopan R. 2009. rtTA toxicity limits the usefulness of the SP-C-rtTA transgenic mouse. Dev Biol 325(1):171-8. [PubMed: 19013447]  [MGI Ref ID J:143537]

Morimoto M; Liu Z; Cheng HT; Winters N; Bader D; Kopan R. 2010. Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate. J Cell Sci 123(Pt 2):213-24. [PubMed: 20048339]  [MGI Ref ID J:156690]

Morimoto M; Nishinakamura R; Saga Y; Kopan R. 2012. Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells. Development 139(23):4365-73. [PubMed: 23132245]  [MGI Ref ID J:190886]

Mucenski ML; Wert SE; Nation JM; Loudy DE; Huelsken J; Birchmeier W; Morrisey EE; Whitsett JA. 2003. beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis. J Biol Chem 278(41):40231-8. [PubMed: 12885771]  [MGI Ref ID J:85946]

Nguyen NM; Kelley DG; Schlueter JA; Meyer MJ; Senior RM; Miner JH. 2005. Epithelial laminin alpha5 is necessary for distal epithelial cell maturation, VEGF production, and alveolization in the developing murine lung. Dev Biol 282(1):111-25. [PubMed: 15936333]  [MGI Ref ID J:104565]

Park KS; Wells JM; Zorn AM; Wert SE; Laubach VE; Fernandez LG; Whitsett JA. 2006. Transdifferentiation of ciliated cells during repair of the respiratory epithelium. Am J Respir Cell Mol Biol 34(2):151-7. [PubMed: 16239640]  [MGI Ref ID J:120191]

Park KS; Wells JM; Zorn AM; Wert SE; Whitsett JA. 2006. Sox17 influences the differentiation of respiratory epithelial cells. Dev Biol 294(1):192-202. [PubMed: 16574095]  [MGI Ref ID J:109303]

Perl AK; Gale E. 2009. FGF signaling is required for myofibroblast differentiation during alveolar regeneration. Am J Physiol Lung Cell Mol Physiol 297(2):L299-308. [PubMed: 19502291]  [MGI Ref ID J:151422]

Perl AK; Kist R; Shan Z; Scherer G; Whitsett JA. 2005. Normal lung development and function after Sox9 inactivation in the respiratory epithelium. Genesis 41(1):23-32. [PubMed: 15645446]  [MGI Ref ID J:95910]

Perl AK; Tichelaar JW; Whitsett JA. 2002. Conditional gene expression in the respiratory epithelium of the mouse. Transgenic Res 11(1):21-9. [PubMed: 11874100]  [MGI Ref ID J:129109]

Perl AK; Wert SE; Loudy DE; Shan Z; Blair PA; Whitsett JA. 2005. Conditional recombination reveals distinct subsets of epithelial cells in trachea, bronchi, and alveoli. Am J Respir Cell Mol Biol 33(5):455-62. [PubMed: 16055670]  [MGI Ref ID J:132772]

Perl AK; Wert SE; Nagy A; Lobe CG; Whitsett JA. 2002. Early restriction of peripheral and proximal cell lineages during formation of the lung. Proc Natl Acad Sci U S A 99(16):10482-7. [PubMed: 12145322]  [MGI Ref ID J:78365]

Perl AK; Zhang L; Whitsett JA. 2009. Conditional expression of genes in the respiratory epithelium in transgenic mice: cautionary notes and toward building a better mouse trap. Am J Respir Cell Mol Biol 40(1):1-3. [PubMed: 19075182]  [MGI Ref ID J:179352]

Proper SP; Saini Y; Greenwood KK; Bramble LA; Downing NJ; Harkema JR; Lapres JJ. 2014. Loss of hypoxia-inducible factor 2 alpha in the lung alveolar epithelium of mice leads to enhanced eosinophilic inflammation in cobalt-induced lung injury. Toxicol Sci 137(2):447-57. [PubMed: 24218148]  [MGI Ref ID J:207763]

Quinton LJ; Jones MR; Robson BE; Simms BT; Whitsett JA; Mizgerd JP. 2008. Alveolar epithelial STAT3, IL-6 family cytokines, and host defense during Escherichia coli pneumonia. Am J Respir Cell Mol Biol 38(6):699-706. [PubMed: 18192501]  [MGI Ref ID J:149718]

Rapp UR; Korn C; Ceteci F; Karreman C; Luetkenhaus K; Serafin V; Zanucco E; Castro I; Potapenko T. 2009. MYC is a metastasis gene for non-small-cell lung cancer. PLoS One 4(6):e6029. [PubMed: 19551151]  [MGI Ref ID J:150188]

Rockich BE; Hrycaj SM; Shih HP; Nagy MS; Ferguson MA; Kopp JL; Sander M; Wellik DM; Spence JR. 2013. Sox9 plays multiple roles in the lung epithelium during branching morphogenesis. Proc Natl Acad Sci U S A 110(47):E4456-64. [PubMed: 24191021]  [MGI Ref ID J:202984]

Romano RA; Ortt K; Birkaya B; Smalley K; Sinha S. 2009. An active role of the DeltaN isoform of p63 in regulating basal keratin genes K5 and K14 and directing epidermal cell fate. PLoS One 4(5):e5623. [PubMed: 19461998]  [MGI Ref ID J:149319]

Saini Y; Greenwood KK; Merrill C; Kim KY; Patial S; Parameswaran N; Harkema JR; LaPres JJ. 2010. Acute cobalt-induced lung injury and the role of hypoxia-inducible factor 1alpha in modulating inflammation. Toxicol Sci 116(2):673-81. [PubMed: 20511350]  [MGI Ref ID J:162927]

Saini Y; Harkema JR; LaPres JJ. 2008. HIF1alpha is essential for normal intrauterine differentiation of alveolar epithelium and surfactant production in the newborn lung of mice. J Biol Chem 283(48):33650-7. [PubMed: 18801745]  [MGI Ref ID J:143384]

Saini Y; Kim KY; Lewandowski R; Bramble LA; Harkema JR; Lapres JJ. 2010. Role of hypoxia-inducible factor 1{alpha} in modulating cobalt-induced lung inflammation. Am J Physiol Lung Cell Mol Physiol 298(2):L139-47. [PubMed: 19915160]  [MGI Ref ID J:157680]

Shaw AT; Meissner A; Dowdle JA; Crowley D; Magendantz M; Ouyang C; Parisi T; Rajagopal J; Blank LJ; Bronson RT; Stone JR; Tuveson DA; Jaenisch R; Jacks T. 2007. Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. Genes Dev 21(6):694-707. [PubMed: 17369402]  [MGI Ref ID J:119477]

Shu W; Guttentag S; Wang Z; Andl T; Ballard P; Lu MM; Piccolo S; Birchmeier W; Whitsett JA; Millar SE; Morrisey EE. 2005. Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung. Dev Biol 283(1):226-39. [PubMed: 15907834]  [MGI Ref ID J:99391]

Simpson DS; Mason-Richie NA; Gettler CA; Wikenheiser-Brokamp KA. 2009. Retinoblastoma family proteins have distinct functions in pulmonary epithelial cells in vivo critical for suppressing cell growth and tumorigenesis. Cancer Res 69(22):8733-41. [PubMed: 19887614]  [MGI Ref ID J:154440]

Sun J; Chen H; Chen C; Whitsett JA; Mishina Y; Bringas P Jr; Ma JC; Warburton D; Shi W. 2008. Prenatal lung epithelial cell-specific abrogation of alk3-bone morphogenetic protein signaling causes neonatal respiratory distress by disrupting distal airway formation. Am J Pathol 172(3):571-82. [PubMed: 18258849]  [MGI Ref ID J:132011]

Tian Y; Zhang Y; Hurd L; Hannenhalli S; Liu F; Lu MM; Morrisey EE. 2011. Regulation of lung endoderm progenitor cell behavior by miR302/367. Development 138(7):1235-45. [PubMed: 21350014]  [MGI Ref ID J:171513]

Tian Y; Zhou R; Rehg JE; Jackowski S. 2007. Role of phosphocholine cytidylyltransferase alpha in lung development. Mol Cell Biol 27(3):975-82. [PubMed: 17130238]  [MGI Ref ID J:118292]

Wan H; Dingle S; Xu Y; Besnard V; Kaestner KH; Ang SL; Wert S; Stahlman MT; Whitsett JA. 2005. Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis. J Biol Chem 280(14):13809-16. [PubMed: 15668254]  [MGI Ref ID J:98750]

Wan H; Kaestner KH; Ang SL; Ikegami M; Finkelman FD; Stahlman MT; Fulkerson PC; Rothenberg ME; Whitsett JA. 2004. Foxa2 regulates alveolarization and goblet cell hyperplasia. Development 131(4):953-64. [PubMed: 14757645]  [MGI Ref ID J:88601]

Wan H; Liu C; Wert SE; Xu W; Liao Y; Zheng Y; Whitsett JA. 2013. CDC42 is required for structural patterning of the lung during development. Dev Biol 374(1):46-57. [PubMed: 23219958]  [MGI Ref ID J:193093]

Wan H; Luo F; Wert SE; Zhang L; Xu Y; Ikegami M; Maeda Y; Bell SM; Whitsett JA. 2008. Kruppel-like factor 5 is required for perinatal lung morphogenesis and function. Development 135(15):2563-72. [PubMed: 18599506]  [MGI Ref ID J:138576]

Wan H; Xu Y; Ikegami M; Stahlman MT; Kaestner KH; Ang SL; Whitsett JA. 2004. Foxa2 is required for transition to air breathing at birth. Proc Natl Acad Sci U S A 101(40):14449-54. [PubMed: 15452354]  [MGI Ref ID J:93473]

Wang IC; Meliton L; Ren X; Zhang Y; Balli D; Snyder J; Whitsett JA; Kalinichenko VV; Kalin TV. 2009. Deletion of Forkhead Box M1 transcription factor from respiratory epithelial cells inhibits pulmonary tumorigenesis. PLoS One 4(8):e6609. [PubMed: 19672312]  [MGI Ref ID J:152467]

Wang IC; Snyder J; Zhang Y; Lander J; Nakafuku Y; Lin J; Chen G; Kalin TV; Whitsett JA; Kalinichenko VV. 2012. Foxm1 mediates cross talk between Kras/mitogen-activated protein kinase and canonical Wnt pathways during development of respiratory epithelium. Mol Cell Biol 32(19):3838-50. [PubMed: 22826436]  [MGI Ref ID J:188926]

Wang IC; Zhang Y; Snyder J; Sutherland MJ; Burhans MS; Shannon JM; Park HJ; Whitsett JA; Kalinichenko VV. 2010. Increased expression of FoxM1 transcription factor in respiratory epithelium inhibits lung sacculation and causes Clara cell hyperplasia. Dev Biol 347(2):301-14. [PubMed: 20816795]  [MGI Ref ID J:166616]

Westphalen K; Gusarova GA; Islam MN; Subramanian M; Cohen TS; Prince AS; Bhattacharya J. 2014. Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity. Nature 506(7489):503-6. [PubMed: 24463523]  [MGI Ref ID J:206960]

White AC; Lavine KJ; Ornitz DM. 2007. FGF9 and SHH regulate mesenchymal Vegfa expression and development of the pulmonary capillary network. Development 134(20):3743-52. [PubMed: 17881491]  [MGI Ref ID J:128368]

White AC; Xu J; Yin Y; Smith C; Schmid G; Ornitz DM. 2006. FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains. Development 133(8):1507-17. [PubMed: 16540513]  [MGI Ref ID J:107406]

Xu B; Chen C; Chen H; Zheng SG; Bringas P Jr; Xu M; Zhou X; Chen D; Umans L; Zwijsen A; Shi W. 2011. Smad1 and its target gene Wif1 coordinate BMP and Wnt signaling activities to regulate fetal lung development. Development 138(5):925-35. [PubMed: 21270055]  [MGI Ref ID J:169137]

Xu J; Tian J; Grumelli SM; Haley KJ; Shapiro SD. 2006. Stage-specific effects of cAMP signaling during distal lung epithelial development. J Biol Chem 281(50):38894-904. [PubMed: 17018522]  [MGI Ref ID J:117640]

Yamamoto H; Yun EJ; Gerber HP; Ferrara N; Whitsett JA; Vu TH. 2007. Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis. Dev Biol 308(1):44-53. [PubMed: 17583691]  [MGI Ref ID J:124125]

Yamamoto K; Ferrari JD; Cao Y; Ramirez MI; Jones MR; Quinton LJ; Mizgerd JP. 2012. Type I alveolar epithelial cells mount innate immune responses during pneumococcal pneumonia. J Immunol 189(5):2450-9. [PubMed: 22844121]  [MGI Ref ID J:189861]

Yanagi S; Kishimoto H; Kawahara K; Sasaki T; Sasaki M; Nishio M; Yajima N; Hamada K; Horie Y; Kubo H; Whitsett JA; Mak TW; Nakano T; Nakazato M; Suzuki A. 2007. Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice. J Clin Invest 117(10):2929-40. [PubMed: 17909629]  [MGI Ref ID J:127405]

Yang MY; Hilton MB; Seaman S; Haines DC; Nagashima K; Burks CM; Tessarollo L; Ivanova PT; Brown HA; Umstead TM; Floros J; Chroneos ZC; St Croix B. 2013. Essential Regulation of Lung Surfactant Homeostasis by the Orphan G Protein-Coupled Receptor GPR116. Cell Rep 3(5):1457-64. [PubMed: 23684610]  [MGI Ref ID J:196943]

Yang YS; Yang MC; Guo Y; Williams OW; Weissler JC. 2009. PLAGL2 expression-induced lung epithelium damages at bronchiolar alveolar duct junction in emphysema: bNip3- and SP-C-associated cell death/injury activity. Am J Physiol Lung Cell Mol Physiol 297(3):L455-66. [PubMed: 19574421]  [MGI Ref ID J:152422]

Yin Y; Betsuyaku T; Garbow JR; Miao J; Govindan R; Ornitz DM. 2013. Rapid induction of lung adenocarcinoma by fibroblast growth factor 9 signaling through FGF receptor 3. Cancer Res 73(18):5730-41. [PubMed: 23867472]  [MGI Ref ID J:204282]

Yin Y; White AC; Huh SH; Hilton MJ; Kanazawa H; Long F; Ornitz DM. 2008. An FGF-WNT gene regulatory network controls lung mesenchyme development. Dev Biol 319(2):426-36. [PubMed: 18533146]  [MGI Ref ID J:137691]

Zhang S; Loch AJ; Radtke F; Egan SE; Xu K. 2013. Jagged1 is the major regulator of Notch-dependent cell fate in proximal airways. Dev Dyn 242(6):678-86. [PubMed: 23526493]  [MGI Ref ID J:198224]

Zhang X; Zhang Y; Tao B; Teng L; Li Y; Cao R; Gui Q; Ye M; Mou X; Cheng H; Hu H; Zhou R; Wu X; Xie Q; Ning W; Lai M; Shen H; Feng GS; Ke Y. 2012. Loss of Shp2 in alveoli epithelia induces deregulated surfactant homeostasis, resulting in spontaneous pulmonary fibrosis. FASEB J 26(6):2338-50. [PubMed: 22362894]  [MGI Ref ID J:187436]

Zhang Y; Goss AM; Cohen ED; Kadzik R; Lepore JJ; Muthukumaraswamy K; Yang J; DeMayo FJ; Whitsett JA; Parmacek MS; Morrisey EE. 2008. A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration. Nat Genet 40(7):862-70. [PubMed: 18536717]  [MGI Ref ID J:138407]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, hemizygous mice can be bred with wiltype siblings. Alternatively, transgenic mice can be bred together. The donating investigator reports that homozygous mice are not viable.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2140.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2782.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   Noncarrier
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
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phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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