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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
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Description
Strain Information
Type Congenic; Mutant Strain; Targeted Mutation; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System See Colony Maintenance Species laboratory mouse Generation N9PN2f2 (28-APR-08) Donating Investigator Daniel Tenen, Beth Israel Deaconess Medical Center Description
Mice homozygous for this C/EBPalpha "floxed" allele (C/EBPalphaF) and hemizygous for the Mx1-cre transgene are viable and fertile, and exhibit no abnormalities in the hematopoietic system. In the absence of cre expression, the C/EBPalphaF allele functions similarly to the wildtype allele. Mx1-Cre transgene expression can be induced by administration of either interferon (alpha or beta) or synthetic double-stranded RNA (such as poly I:C), leading to deletion of the "floxed" gene. Following 3-4.5 weeks of poly I:C treatment, deletion efficiency is greater than 95% in hematopoietic tissues, and C/EBPalpha protein is undetectable in bone marrow. These poly I:C-treated, mice have defective myeloid cell development, increased hematopoietic stem cell repopulating activity, and a significantly increased myeloblast population in the bone marrow compartment. These mutant mice may be useful in studies of hematopoietic cell (e.g. myeloid and basophil progenitor cell) development and function, cancer (e.g. acute myeloid leukemia), and alveolar cell differentiation.Development
These mice contain the C/EBPalphaF targeted mutation and the Mx1-Cre transgene. To generate the C/EBPalphaF mutant mice, a targeting vector was designed to flank the single Cebpa exon with loxP sites. A neomycin resistance cassette was also inserted between the exon and downstream loxP site. This vector was introduced into 129S6/SvEvTac-derived TC1 embryonic stem (ES) cells. Correctly targeted cells were injected into C57BL/6 blastocysts and then implanted into foster mothers. Mutant offspring were backcrossed for 9 generations to C57BL/6 mice. The Mx1-Cre transgenic construct was designed with the mouse Mx1 promoter, nuclear localization sequence-modified Cre recombinase, and a 2.1 kb fragment from the human growth hormone gene (to provide the splicing and polyadenylation signals). Transgenic mice were generated on a mixed CBA and C57BL/6 genetic background by Dr. Klaus Rajewsky (Harvard Medical School). Transgenic mice were sent to Dr. Daniel Tenen (Harvard Medical School) and then backcrossed for 9 generations to C57BL/6 mice. After backcrossing, the C/EBPalphaF mutant and Mx1-Cre transgenic strains were bred together in the laboratory of Dr. Tenen for many generations prior to arrival at The Jackson Laboratory.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Cebpatm1Dgt allele
006447 B6.129S6(CBA)-Cebpatm1Dgt/J View Strains carrying Cebpatm1Dgt (1 strain)
003556 B6.Cg-Tg(Mx1-cre)1Cgn/J 005673 C.Cg-Tg(Mx1-cre)1Cgn/J 004192 STOCK Mttptm2Sgy Ldlrtm1Her Apobtm2Sgy Tg(Mx1-cre)1Cgn/J 002527 STOCK Tg(Mx1-cre)1Cgn/J
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Cebpatm1Dgt/Cebpatm1Dgt Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac (conditional)
- life span-post-weaning/aging
- premature death (MGI Ref ID J:94682)
- mutants treated with poly I:C rarely survive beyond 4-5 weeks of age due to granulocytopenia and sepsis
- hematopoietic system phenotype
- abnormal myelopoiesis (MGI Ref ID J:94682)
- a dramatic loss of Gr-1+ Mac-1+ neutrophils/monocytes is seen in the bone marrow, spleen, and peripheral blood, however T and B cell numbers are normal
- failure of myelopoiesis (MGI Ref ID J:94682)
- after poly I:C treatment myelocytes, neutrophils, monocytes, and eosinophils are rarely seen in the bone marrow and the number of immature myeloblasts is increased 32%
- in vitro common myeloid progenitor cells fail to form any mature granulocyte-macrophage, macrophage, or granulocytic colonies
- decreased granulocyte number (MGI Ref ID J:94682)
- injection of poly I:C at 2 days after birth resulted in absence of mature granulocytes, however mutants do not develop anemia, thrombocytopenia, or leukemia
- immune system phenotype
- abnormal myelopoiesis (MGI Ref ID J:94682)
- a dramatic loss of Gr-1+ Mac-1+ neutrophils/monocytes is seen in the bone marrow, spleen, and peripheral blood, however T and B cell numbers are normal
- failure of myelopoiesis (MGI Ref ID J:94682)
- after poly I:C treatment myelocytes, neutrophils, monocytes, and eosinophils are rarely seen in the bone marrow and the number of immature myeloblasts is increased 32%
- in vitro common myeloid progenitor cells fail to form any mature granulocyte-macrophage, macrophage, or granulocytic colonies
- decreased granulocyte number (MGI Ref ID J:94682)
- injection of poly I:C at 2 days after birth resulted in absence of mature granulocytes, however mutants do not develop anemia, thrombocytopenia, or leukemia
- sepsis (MGI Ref ID J:94682)
This mouse can be used to support research in many areas including:
cre relatedCancer Research
Increased Tumor Incidence
Leukemia: lymphocytic
Cell Biology Research
Transcriptional Regulation
Developmental Biology Research
Lymphoid Tissue Defects
hematopoietic defects
Hematological Research
Hematopoietic Defects
Immunological Defects
Immunology and Inflammation Research
Lymphoid Tissue Defects
hematopoietic development
myeloid hyperplasia
Internal/Organ Research
Lymphoid Tissue Defects
Research Tools
Cancer Research
Leukemia
myeloma and hybridoma production
Cre-lox System
loxP-flanked Sequences
Cre Recombinase Expression: Inducible
Hematological Research
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Cebpatm1Dgt | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Daniel G Tenen | ||
| Allele Type | Targeted (Floxed/Frt) | ||
| Common Name(s) | C/EBPalphaF; | ||
| Mutation Made By | Daniel Tenen, Beth Israel Deaconess Medical Center | ||
| Strain of Origin | 129S6/SvEvTac | ||
| ES Cell Line Name | TC-1 | ||
| ES Cell Line Strain | 129S6/SvEvTac | ||
| Gene Symbol and Name | Cebpa, CCAAT/enhancer binding protein (C/EBP), alpha | ||
| Chromosome | 7 | ||
| Gene Common Name(s) | C/EBP alpha; C/EBP-alpha; C/ebpalpha; CCAAT/enhancer binding protein (C/EBP); CEBP; Cebp; DBPCEP; | ||
| Molecular Note | LoxP sites were inserted to flank the single exon and a neo cassette inserted downstream of the exon. Western blot of whole-cell lysates of adult liver and total bone marrow cells showed that protein was present in mutants. [MGI Ref ID J:94682] | ||
| Allele Symbol | Tg(Mx1-cre)1Cgn | ||
| Allele Name | transgene insertion 1, University of Cologne | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | Mx-Cre; Mx-Cre 31; Mx1-Cre; Mx1cre; MxCre; | ||
| Mutation Made By | Ralf Kuhn, University of Cologne | ||
| Strain of Origin | (C57BL/6 x CBA)F2 | ||
| Site of Expression | widespread pattern of expression; promoter induced to high levels of transcription by administration of interferon alpha, interferon beta, or synthetic double-stranded RNA; provides capability to induce the "knockout" at any time during development | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Mx1, myxovirus (influenza virus) resistance 1, mouse, laboratory | ||
| Gene Symbol and Name | Tg(Mx1-cre)1Cgn, transgene insertion 1, Klaus Rajewsky | ||
| Chromosome | UN | ||
| Gene Common Name(s) | Mx-Cre; Mx-Cre 31; Mx1-Cre; Mx1cre; MxCre; | ||
| Driver Note | Mx1 | ||
| Molecular Note | This transgene expresses Cre recombinase under the control of an inducible Mx1 promoter, which is silent in healthy mice, and active in the liver and in lymphocytes after induction with IFN or pI-pC. The construct also contains a 2.1 kb fragment from thehuman growth hormone gene. [MGI Ref ID J:105040] [MGI Ref ID J:67927] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Cebpatm1Dgt, Standard PCR
Generic Cre Melt Curve Analysis, Melt Curve Analysis
Generic Cre, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Zhang P; Iwasaki-Arai J; Iwasaki H; Fenyus ML; Dayaram T; Owens BM; Shigematsu H; Levantini E; Huettner CS; Lekstrom-Himes JA; Akashi K; Tenen DG. 2004. Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha. Immunity 21(6):853-63. [PubMed: 15589173] [MGI Ref ID J:94682]
Additional References
Cebpatm1Dgt relatedTg(Mx1-cre)1Cgn relatedArinobu Y; Iwasaki H; Gurish MF; Mizuno S; Shigematsu H; Ozawa H; Tenen DG; Austen KF; Akashi K. 2005. Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis. Proc Natl Acad Sci U S A 102(50):18105-10. [PubMed: 16330751] [MGI Ref ID J:104357]
Basseres DS; Levantini E; Ji H; Monti S; Elf S; Dayaram T; Fenyus M; Kocher O; Golub T; Wong KK; Halmos B; Tenen DG. 2006. Respiratory failure due to differentiation arrest and expansion of alveolar cells following lung-specific loss of the transcription factor C/EBPalpha in mice. Mol Cell Biol 26(3):1109-23. [PubMed: 16428462] [MGI Ref ID J:105593]
Hirai H; Zhang P; Dayaram T; Hetherington CJ; Mizuno S; Imanishi J; Akashi K; Tenen DG. 2006. C/EBPbeta is required for 'emergency' granulopoiesis. Nat Immunol 7(7):732-9. [PubMed: 16751774] [MGI Ref ID J:112664]
Iwasaki H; Mizuno S; Arinobu Y; Ozawa H; Mori Y; Shigematsu H; Takatsu K; Tenen DG; Akashi K. 2006. The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages. Genes Dev 20(21):3010-21. [PubMed: 17079688] [MGI Ref ID J:114679]
Adelman CA; De S; Petrini JH. 2009. Rad50 is dispensable for the maintenance and viability of postmitotic tissues. Mol Cell Biol 29(2):483-92. [PubMed: 19001091] [MGI Ref ID J:144766]
Akerman ME; Pilch J; Peters D; Ruoslahti E. 2005. Angiostatic peptides use plasma fibronectin to home to angiogenic vasculature. Proc Natl Acad Sci U S A 102(6):2040-5. [PubMed: 15687502] [MGI Ref ID J:96503]
Akiyama TE; Sakai S; Lambert G; Nicol CJ; Matsusue K; Pimprale S; Lee YH; Ricote M; Glass CK; Brewer HB Jr; Gonzalez FJ. 2002. Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux. Mol Cell Biol 22(8):2607-19. [PubMed: 11909955] [MGI Ref ID J:75777]
Aliprantis AO; Ueki Y; Sulyanto R; Park A; Sigrist KS; Sharma SM; Ostrowski MC; Olsen BR; Glimcher LH. 2008. NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J Clin Invest 118(11):3775-89. [PubMed: 18846253] [MGI Ref ID J:144598]
Allende ML; Zhou D; Kalkofen DN; Benhamed S; Tuymetova G; Borowski C; Bendelac A; Proia RL. 2008. S1P1 receptor expression regulates emergence of NKT cells in peripheral tissues. FASEB J 22(1):307-15. [PubMed: 17785606] [MGI Ref ID J:134801]
Alonzi T; Maritano D; Gorgoni B; Rizzuto G; Libert C; Poli V. 2001. Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene activation in the liver. Mol Cell Biol 21(5):1621-32. [PubMed: 11238899] [MGI Ref ID J:67357]
Alonzi T; Newton IP; Bryce PJ; Di Carlo E; Lattanzio G; Tripodi M; Musiani P; Poli V. 2004. Induced somatic inactivation of STAT3 in mice triggers the development of a fulminant form of enterocolitis. Cytokine 26(2):45-56. [PubMed: 15050604] [MGI Ref ID J:146716]
Anwar K; Iqbal J; Hussain MM. 2007. Mechanisms involved in vitamin E transport by primary enterocytes and in vivo absorption. J Lipid Res 48(9):2028-38. [PubMed: 17582142] [MGI Ref ID J:125237]
Araya R; Eckardt D; Maxeiner S; Kruger O; Theis M; Willecke K; Saez JC. 2005. Expression of connexins during differentiation and regeneration of skeletal muscle: functional relevance of connexin43. J Cell Sci 118(Pt 1):27-37. [PubMed: 15601660] [MGI Ref ID J:94694]
Baena E; Gandarillas A; Vallespinos M; Zanet J; Bachs O; Redondo C; Fabregat I; Martinez-A C; de Alboran IM. 2005. c-Myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver. Proc Natl Acad Sci U S A 102(20):7286-91. [PubMed: 15857952] [MGI Ref ID J:99242]
Baena E; Ortiz M; Martinez-A C; de Alboran IM. 2007. c-Myc is essential for hematopoietic stem cell differentiation and regulates Lin(-)Sca-1(+)c-Kit(-) cell generation through p21. Exp Hematol 35(9):1333-43. [PubMed: 17637497] [MGI Ref ID J:126563]
Banerjee ER; Jiang Y; Henderson WR Jr; Latchman Y; Papayannopoulou T. 2009. Absence of alpha 4 but not beta 2 integrins restrains development of chronic allergic asthma using mouse genetic models. Exp Hematol 37(6):715-727.e3. [PubMed: 19463772] [MGI Ref ID J:151240]
Banerjee ER; Jiang Y; Henderson WR Jr; Scott LM; Papayannopoulou T. 2007. Alpha4 and beta2 integrins have nonredundant roles for asthma development, but for optimal allergen sensitization only alpha4 is critical. Exp Hematol 35(4):605-17. [PubMed: 17379071] [MGI Ref ID J:123141]
Banerjee ER; Latchman YE; Jiang Y; Priestley GV; Papayannopoulou T. 2008. Distinct changes in adult lymphopoiesis in Rag2-/- mice fully reconstituted by alpha4-deficient adult bone marrow cells. Exp Hematol 36(8):1004-13. [PubMed: 18468770] [MGI Ref ID J:139405]
Bauer M; Brakebusch C; Coisne C; Sixt M; Wekerle H; Engelhardt B; Fassler R. 2009. Beta1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity. Proc Natl Acad Sci U S A 106(6):1920-5. [PubMed: 19179279] [MGI Ref ID J:144959]
Behrens A; Sibilia M; David JP; Mohle-Steinlein U; Tronche F; Schutz G; Wagner EF. 2002. Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver. EMBO J 21(7):1782-90. [PubMed: 11927562] [MGI Ref ID J:75863]
Benz C; Martins VC; Radtke F; Bleul CC. 2008. The stream of precursors that colonizes the thymus proceeds selectively through the early T lineage precursor stage of T cell development. J Exp Med 205(5):1187-99. [PubMed: 18458114] [MGI Ref ID J:136220]
Berberich S; Dahne S; Schippers A; Peters T; Muller W; Kremmer E; Forster R; Pabst O. 2008. Differential molecular and anatomical basis for B cell migration into the peritoneal cavity and omental milky spots. J Immunol 180(4):2196-203. [PubMed: 18250426] [MGI Ref ID J:132002]
Bergo MO; Lieu HD; Gavino BJ; Ambroziak P; Otto JC; Casey PJ; Walker QM; Young SG. 2004. On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy. J Biol Chem 279(6):4729-36. [PubMed: 14625273] [MGI Ref ID J:87958]
Besseyrias V; Fiorini E; Strobl LJ; Zimber-Strobl U; Dumortier A; Koch U; Arcangeli ML; Ezine S; Macdonald HR; Radtke F. 2007. Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation. J Exp Med 204(2):331-43. [PubMed: 17261636] [MGI Ref ID J:125373]
Bleuming SA; He XC; Kodach LL; Hardwick JC; Koopman FA; Ten Kate FJ; van Deventer SJ; Hommes DW; Peppelenbosch MP; Offerhaus GJ; Li L; van den Brink GR. 2007. Bone morphogenetic protein signaling suppresses tumorigenesis at gastric epithelial transition zones in mice. Cancer Res 67(17):8149-55. [PubMed: 17804727] [MGI Ref ID J:124881]
Borowiak M; Garratt AN; Wustefeld T; Strehle M; Trautwein C; Birchmeier C. 2004. Met provides essential signals for liver regeneration. Proc Natl Acad Sci U S A 101(29):10608-13. [PubMed: 15249655] [MGI Ref ID J:91484]
Bourgeois C; Hao Z; Rajewsky K; Potocnik AJ; Stockinger B. 2008. Ablation of thymic export causes accelerated decay of naive CD4 T cells in the periphery because of activation by environmental antigen. Proc Natl Acad Sci U S A 105(25):8691-6. [PubMed: 18562288] [MGI Ref ID J:143955]
Brakebusch C; Fillatreau S; Potocnik AJ; Bungartz G; Wilhelm P; Svensson M; Kearney P; Korner H; Gray D; Fassler R. 2002. Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response. Immunity 16(3):465-77. [PubMed: 11911830] [MGI Ref ID J:75623]
Braun BS; Tuveson DA; Kong N; Le DT; Kogan SC; Rozmus J; Le Beau MM; Jacks TE; Shannon KM. 2004. Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder. Proc Natl Acad Sci U S A 101(2):597-602. [PubMed: 14699048] [MGI Ref ID J:87429]
Cales C; Roman-Trufero M; Pavon L; Serrano I; Melgar T; Endoh M; Perez C; Koseki H; Vidal M. 2008. Inactivation of the polycomb group protein Ring1B unveils an antiproliferative role in hematopoietic cell expansion and cooperation with tumorigenesis associated with Ink4a deletion. Mol Cell Biol 28(3):1018-28. [PubMed: 18039844] [MGI Ref ID J:130397]
Camerer E; Regard JB; Cornelissen I; Srinivasan Y; Duong DN; Palmer D; Pham TH; Wong JS; Pappu R; Coughlin SR. 2009. Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. J Clin Invest 119(7):1871-9. [PubMed: 19603543] [MGI Ref ID J:152547]
Cancelas JA; Jansen M; Williams DA. 2006. The role of chemokine activation of Rac GTPases in hematopoietic stem cell marrow homing, retention, and peripheral mobilization. Exp Hematol 34(8):976-85. [PubMed: 16863904] [MGI Ref ID J:111908]
Caton ML; Smith-Raska MR; Reizis B. 2007. Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen. J Exp Med 204(7):1653-64. [PubMed: 17591855] [MGI Ref ID J:125869]
Chan G; Kalaitzidis D; Usenko T; Kutok JL; Yang W; Mohi MG; Neel BG. 2009. Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis. Blood 113(18):4414-24. [PubMed: 19179468] [MGI Ref ID J:148430]
Chan IT; Kutok JL; Williams IR; Cohen S; Kelly L; Shigematsu H; Johnson L; Akashi K; Tuveson DA; Jacks T; Gilliland DG. 2004. Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease. J Clin Invest 113(4):528-38. [PubMed: 14966562] [MGI Ref ID J:88163]
Chan IT; Kutok JL; Williams IR; Cohen S; Moore S; Shigematsu H; Ley TJ; Akashi K; Le Beau MM; Gilliland DG. 2006. Oncogenic K-ras cooperates with PML-RAR alpha to induce an acute promyelocytic leukemia-like disease. Blood 108(5):1708-15. [PubMed: 16675706] [MGI Ref ID J:115068]
Chen C; Liu Y; Liu R; Ikenoue T; Guan KL; Liu Y; Zheng P. 2008. TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J Exp Med 205(10):2397-408. [PubMed: 18809716] [MGI Ref ID J:140099]
Chen H; Zou Z; Sarratt KL; Zhou D; Zhang M; Sebzda E; Hammer DA; Kahn ML. 2006. In vivo beta1 integrin function requires phosphorylation-independent regulation by cytoplasmic tyrosines. Genes Dev 20(8):927-32. [PubMed: 16618804] [MGI Ref ID J:108331]
Chou WC; Levy DE; Lee CK. 2006. STAT3 positively regulates an early step in B-cell development. Blood 108(9):3005-11. [PubMed: 16825489] [MGI Ref ID J:140460]
Cobas M; Wilson A; Ernst B; Mancini SJ; MacDonald HR; Kemler R; Radtke F. 2004. Beta-catenin is dispensable for hematopoiesis and lymphopoiesis. J Exp Med 199(2):221-9. [PubMed: 14718516] [MGI Ref ID J:89995]
Collazo MM; Wood D; Paraiso KH; Lund E; Engelman RW; Le CT; Stauch D; Kotsch K; Kerr WG. 2009. SHIP limits immunoregulatory capacity in the T-cell compartment. Blood 113(13):2934-44. [PubMed: 19136659] [MGI Ref ID J:146908]
Curtis DJ; Hall MA; Van Stekelenburg LJ; Robb L; Jane SM; Begley CG. 2004. SCL is required for normal function of short-term repopulating hematopoietic stem cells. Blood 103(9):3342-8. [PubMed: 14726374] [MGI Ref ID J:90290]
Dakic A; Metcalf D; Di Rago L; Mifsud S; Wu L; Nutt SL. 2005. PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis. J Exp Med 201(9):1487-502. [PubMed: 15867096] [MGI Ref ID J:98188]
Das M; Sabio G; Jiang F; Rincon M; Flavell RA; Davis RJ. 2009. Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell 136(2):249-60. [PubMed: 19167327] [MGI Ref ID J:147632]
Deckert M; Lutjen S; Leuker CE; Kwok LY; Strack A; Muller W; Wagner N; Schluter D. 2003. Mice with neonatally induced inactivation of the vascular cell adhesion molecule-1 fail to control the parasite in Toxoplasma encephalitis. Eur J Immunol 33(5):1418-28. [PubMed: 12731069] [MGI Ref ID J:83353]
Demuth I; Frappart PO; Hildebrand G; Melchers A; Lobitz S; Stockl L; Varon R; Herceg Z; Sperling K; Wang ZQ; Digweed M. 2004. An inducible null mutant murine model of Nijmegen breakage syndrome proves the essential function of NBS1 in chromosomal stability and cell viability. Hum Mol Genet 13(20):2385-97. [PubMed: 15333589] [MGI Ref ID J:93598]
Eferl R; Ricci R; Kenner L; Zenz R; David JP; Rath M; Wagner EF. 2003. Liver Tumor Development. c-Jun Antagonizes the Proapoptotic Activity of p53. Cell 112(2):181-92. [PubMed: 12553907] [MGI Ref ID J:81543]
El Andaloussi A; Graves S; Meng F; Mandal M; Mashayekhi M; Aifantis I. 2006. Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus. Nat Immunol 7(4):418-26. [PubMed: 16518394] [MGI Ref ID J:112555]
Enquist IB; Nilsson E; Ooka A; Mansson JE; Olsson K; Ehinger M; Brady RO; Richter J; Karlsson S. 2006. Effective cell and gene therapy in a murine model of Gaucher disease. Proc Natl Acad Sci U S A 103(37):13819-24. [PubMed: 16954197] [MGI Ref ID J:113751]
Escribano O; Guillen C; Nevado C; Gomez-Hernandez A; Kahn CR; Benito M. 2009. Beta-Cell hyperplasia induced by hepatic insulin resistance: role of a liver-pancreas endocrine axis through insulin receptor A isoform. Diabetes 58(4):820-8. [PubMed: 19136656] [MGI Ref ID J:151043]
Ficara F; Murphy MJ; Lin M; Cleary ML. 2008. Pbx1 regulates self-renewal of long-term hematopoietic stem cells by maintaining their quiescence. Cell Stem Cell 2(5):484-96. [PubMed: 18462698] [MGI Ref ID J:149799]
Fu J; Gerhardt H; McDaniel JM; Xia B; Liu X; Ivanciu L; Ny A; Hermans K; Silasi-Mansat R; McGee S; Nye E; Ju T; Ramirez MI; Carmeliet P; Cummings RD; Lupu F; Xia L. 2008. Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice. J Clin Invest 118(11):3725-37. [PubMed: 18924607] [MGI Ref ID J:144581]
Galan-Caridad JM; Harel S; Arenzana TL; Hou ZE; Doetsch FK; Mirny LA; Reizis B. 2007. Zfx controls the self-renewal of embryonic and hematopoietic stem cells. Cell 129(2):345-57. [PubMed: 17448993] [MGI Ref ID J:149654]
Gallo EM; Ho L; Winslow MM; Staton TL; Crabtree GR. 2008. Selective role of calcineurin in haematopoiesis and lymphopoiesis. EMBO Rep 9(11):1141-8. [PubMed: 18818667] [MGI Ref ID J:143345]
Gao J; Graves S; Koch U; Liu S; Jankovic V; Buonamici S; El Andaloussi A; Nimer SD; Kee BL; Taichman R; Radtke F; Aifantis I. 2009. Hedgehog signaling is dispensable for adult hematopoietic stem cell function. Cell Stem Cell 4(6):548-58. [PubMed: 19497283] [MGI Ref ID J:149820]
Garcia P; Berlanga O; Watson R; Frampton J. 2005. Generation of a conditional allele of the B-myb gene. Genesis 43(4):189-95. [PubMed: 16283626] [MGI Ref ID J:103413]
Geisler F; Algul H; Paxian S; Schmid RM. 2007. Genetic inactivation of RelA/p65 sensitizes adult mouse hepatocytes to TNF-induced apoptosis in vivo and in vitro. Gastroenterology 132(7):2489-503. [PubMed: 17570221] [MGI Ref ID J:128311]
Gerber HP; Hillan KJ; Ryan AM; Kowalski J; Keller GA; Rangell L ; Wright BD ; Radtke F ; Aguet M ; Ferrara N. 1999. VEGF is required for growth and survival in neonatal mice. Development 126(6):1149-59. [PubMed: 10021335] [MGI Ref ID J:52793]
Gerber HP; Malik AK; Solar GP; Sherman D; Liang XH; Meng G; Hong K; Marsters JC; Ferrara N. 2002. VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism. Nature 417(6892):954-8. [PubMed: 12087404] [MGI Ref ID J:77388]
Goren A; Simchen G; Fibach E; Szabo PE; Tanimoto K; Chakalova L; Pfeifer GP; Fraser PJ; Engel JD; Cedar H. 2006. Fine tuning of globin gene expression by DNA methylation. PLoS ONE 1:e46. [PubMed: 17183675] [MGI Ref ID J:129359]
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Sirac C; Bridoux F; Carrion C; Devuyst O; Fernandez B; Goujon JM; El Hamel C; Aldigier JC; Touchard G; Cogne M. 2006. Role of the monoclonal kappa chain V domain and reversibility of renal damage in a transgenic model of acquired Fanconi syndrome. Blood 108(2):536-43. [PubMed: 16543471] [MGI Ref ID J:135758]
Sjogren K; Sheng M; Moverare S; Liu JL; Wallenius K; Tornell J; Isaksson O; Jansson JO; Mohan S; Ohlsson C. 2002. Effects of liver-derived insulin-like growth factor I on bone metabolism in mice. J Bone Miner Res 17(11):1977-87. [PubMed: 12412805] [MGI Ref ID J:111425]
Skogsberg J; Dicker A; Ryden M; Astrom G; Nilsson R; Bhuiyan H; Vitols S; Mairal A; Langin D; Alberts P; Walum E; Tegner J; Hamsten A; Arner P; Bjorkegren J. 2008. ApoB100-LDL acts as a metabolic signal from liver to peripheral fat causing inhibition of lipolysis in adipocytes. PLoS ONE 3(11):e3771. [PubMed: 19020660] [MGI Ref ID J:143905]
Skogsberg J; Lundstrom J; Kovacs A; Nilsson R; Noori P; Maleki S; Kohler M; Hamsten A; Tegner J; Bjorkegren J. 2008. Transcriptional profiling uncovers a network of cholesterol-responsive atherosclerosis target genes. PLoS Genet 4(3):e1000036. [PubMed: 18369455] [MGI Ref ID J:136835]
Song R; Kim YW; Koo BK; Jeong HW; Yoon MJ; Yoon KJ; Jun DJ; Im SK; Shin J; Kong MP; Kim KT; Yoon K; Kong YY. 2008. Mind bomb 1 in the lymphopoietic niches is essential for T and marginal zone B cell development. J Exp Med 205(11):2525-36. [PubMed: 18824586] [MGI Ref ID J:140960]
Souabni A; Cobaleda C; Schebesta M; Busslinger M. 2002. Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1. Immunity 17(6):781-93. [PubMed: 12479824] [MGI Ref ID J:80815]
Souroullas GP; Salmon JM; Sablitzky F; Curtis DJ; Goodell MA. 2009. Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival. Cell Stem Cell 4(2):180-6. [PubMed: 19200805] [MGI Ref ID J:149689]
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Viatour P; Somervaille TC; Venkatasubrahmanyam S; Kogan S; McLaughlin ME; Weissman IL; Butte AJ; Passegue E; Sage J. 2008. Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family. Cell Stem Cell 3(4):416-28. [PubMed: 18940733] [MGI Ref ID J:149791]
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Walkley CR; Orkin SH. 2006. Rb is dispensable for self-renewal and multilineage differentiation of adult hematopoietic stem cells. Proc Natl Acad Sci U S A 103(24):9057-62. [PubMed: 16754850] [MGI Ref ID J:111063]
Wallenius K; Sjogren K; Peng XD; Park S; Wallenius V; Liu JL; Umaerus M; Wennbo H; Isaksson O; Frohman L; Kineman R; Ohlsson C; Jansson JO. 2001. Liver-derived igf-i regulates gh secretion at the pituitary level in mice. Endocrinology 142(11):4762-70. [PubMed: 11606442] [MGI Ref ID J:72793]
Wang J; Iwasaki H; Krivtsov A; Febbo PG; Thorner AR; Ernst P; Anastasiadou E; Kutok JL; Kogan SC; Zinkel SS; Fisher JK; Hess JL; Golub TR; Armstrong SA; Akashi K; Korsmeyer SJ. 2005. Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease. EMBO J 24(2):368-81. [PubMed: 15635450] [MGI Ref ID J:95914]
Wang L; Wang CM; Hou LH; Dou GR; Wang YC; Hu XB; He F; Feng F; Zhang HW; Liang YM; Dou KF; Han H. 2009. Disruption of the transcription factor recombination signal-binding protein-Jkappa (RBP-J) leads to veno-occlusive disease and interfered liver regeneration in mice. Hepatology 49(1):268-77. [PubMed: 19065680] [MGI Ref ID J:153784]
Wang L; Wang YC; Hu XB; Zhang BF; Dou GR; He F; Gao F; Feng F; Liang YM; Dou KF; Han H. 2009. Notch-RBP-J signaling regulates the mobilization and function of endothelial progenitor cells by dynamic modulation of CXCR4 expression in mice. PLoS One 4(10):e7572. [PubMed: 19859544] [MGI Ref ID J:154034]
Wang XD; Leow CC; Zha J; Tang Z; Modrusan Z; Radtke F; Aguet M; de Sauvage FJ; Gao WQ. 2006. Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation. Dev Biol 290(1):66-80. [PubMed: 16360140] [MGI Ref ID J:104805]
Wang Y; Wimmer U; Lichtlen P; Inderbitzin D; Stieger B; Meier PJ; Hunziker L; Stallmach T; Forrer R; Rulicke T; Georgiev O; Schaffner W. 2004. Metal-responsive transcription factor-1 (MTF-1) is essential for embryonic liver development and heavy metal detoxification in the adult liver. FASEB J 18(10):1071-9. [PubMed: 15226267] [MGI Ref ID J:91119]
Wang YC; Hu XB; He F; Feng F; Wang L; Li W; Zhang P; Li D; Jia ZS; Liang YM; Han H. 2009. Lipopolysaccharide-induced maturation of bone marrow-derived dendritic cells is regulated by notch signaling through the up-regulation of CXCR4. J Biol Chem 284(23):15993-6003. [PubMed: 19357083] [MGI Ref ID J:150688]
Wang Z; Li G; Tse W; Bunting KD. 2009. Conditional deletion of STAT5 in adult mouse hematopoietic stem cells causes loss of quiescence and permits efficient nonablative stem cell replacement. Blood 113(20):4856-65. [PubMed: 19258595] [MGI Ref ID J:148957]
Waning DL; Li B; Jia N; Naaldijk Y; Goebel WS; HogenEsch H; Chun KT. 2008. Cul4A is required for hematopoietic cell viability and its deficiency leads to apoptosis. Blood 112(2):320-9. [PubMed: 18339895] [MGI Ref ID J:138468]
Weischenfeldt J; Damgaard I; Bryder D; Theilgaard-Monch K; Thoren LA; Nielsen FC; Jacobsen SE; Nerlov C; Porse BT. 2008. NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements. Genes Dev 22(10):1381-96. [PubMed: 18483223] [MGI Ref ID J:134765]
Wells CM; Walmsley M; Ooi S; Tybulewicz V; Ridley AJ. 2004. Rac1-deficient macrophages exhibit defects in cell spreading and membrane ruffling but not migration. J Cell Sci 117(Pt 7):1259-68. [PubMed: 14996945] [MGI Ref ID J:119419]
Wilson A; Ardiet DL; Saner C; Vilain N; Beermann F; Aguet M; Macdonald HR; Zilian O. 2007. Normal hemopoiesis and lymphopoiesis in the combined absence of numb and numblike. J Immunol 178(11):6746-51. [PubMed: 17513721] [MGI Ref ID J:133550]
Wilson A; MacDonald HR; Radtke F. 2001. Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus. J Exp Med 194(7):1003-12. [PubMed: 11581321] [MGI Ref ID J:119436]
Wilson A; Murphy MJ; Oskarsson T; Kaloulis K; Bettess MD; Oser GM; Pasche AC; Knabenhans C; Macdonald HR; Trumpp A. 2004. c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. Genes Dev 18(22):2747-63. [PubMed: 15545632] [MGI Ref ID J:93882]
Wimmer U; Wang Y; Georgiev O; Schaffner W. 2005. Two major branches of anti-cadmium defense in the mouse: MTF-1/metallothioneins and glutathione. Nucleic Acids Res 33(18):5715-27. [PubMed: 16221973] [MGI Ref ID J:102512]
Wirth KG; Ricci R; Gimenez-Abian JF; Taghybeeglu S; Kudo NR; Jochum W; Vasseur-Cognet M; Nasmyth K. 2004. Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation. Genes Dev 18(1):88-98. [PubMed: 14724179] [MGI Ref ID J:87782]
Wirth KG; Wutz G; Kudo NR; Desdouets C; Zetterberg A; Taghybeeglu S; Seznec J; Ducos GM; Ricci R; Firnberg N; Peters JM; Nasmyth K. 2006. Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression. J Cell Biol 172(6):847-60. [PubMed: 16533945] [MGI Ref ID J:107916]
Woodland RT; Fox CJ; Schmidt MR; Hammerman PS; Opferman JT; Korsmeyer SJ; Hilbert DM; Thompson CB. 2008. Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival. Blood 111(2):750-60. [PubMed: 17942753] [MGI Ref ID J:130058]
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Health & husbandry
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Animal Health Reports
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Colony Maintenance
Breeding & Husbandry When maintaining a live colony, mice homozygous for the "floxed" mutation and hemizygous for the transgene are bred. Mating System See above Diet Information LabDiet® 5K52/5K67
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Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $243.50 Female or Male Homozygous for Cebpatm1Dgt, Hemizygous for Tg(Mx1-cre)1Cgn
Pairs /Price (US dollars $) Pair Genotype $487.00 Homozygous for Cebpatm1Dgt, Hemizygous for Tg(Mx1-cre)1Cgn x Homozygous for Cebpatm1Dgt, Hemizygous for Tg(Mx1-cre)1Cgn
Additional Supply Details
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $316.60 Female or Male Homozygous for Cebpatm1Dgt, Hemizygous for Tg(Mx1-cre)1Cgn
Pairs /Price (US dollars $) Pair Genotype $633.10 Homozygous for Cebpatm1Dgt, Hemizygous for Tg(Mx1-cre)1Cgn x Homozygous for Cebpatm1Dgt, Hemizygous for Tg(Mx1-cre)1Cgn
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
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Control Information
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| 000664 C57BL/6J | ||
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| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.