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| These transgenic mice express Cre recombinase under the control of a tetracycline-responsive promoter element (TRE or tetO) and are an effective tool for generating inducible, tissue-specific, targeted mutants to study cell lineage during development. When bred with another transgenic mouse expressing reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA), Cre mediated recombination in the resulting bitransgenic offspring can be regulated with the tetracycline analog, doxycycline. | |||||||||||||||||||
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- Disease & phenotype
- Genes & alleles
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Description
Strain Information
Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Noncarrier x Hemizygote (Female x Male) 11-OCT-08 Species laboratory mouse Generation N10F9 (30-JUN-11)
Generation DefinitionsDonating Investigator IMR Colony, The Jackson Laboratory Description
Hemizygous transgenic mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. These transgenic mice express Cre recombinase under the control of a tetracycline-responsive promoter element (TRE; tetO). When hemizygotes are bred with another transgenic mouse expressing either reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA) under the control of tissue-specific promoters, Cre recombinase expression and Cre-mediated recombination in the appropriate tissues of the bitransgenic offspring can be regulated with the tetracycline analog, doxycycline. This strain represents an effective tool for generating inducible tissue specific-targeted mutants to study cell lineage during development.In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
Development
A transgenic construct containing the cre recombinase gene under the control of the tetracycline-responsive promoter element (TRE or tetO), minimal CMV promoter and MT-1 polyadenylation site sequence was injected into mixed C57BL/6 and 129 background embryos. Founder mice were bred to FVB/N animals. Upon arrival at The Jackson Laboratory, these mice were backcrossed to C57BL/6J mice for at least 5 generations.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Tg(tetO-cre)1Jaw allele
006244 C.Cg-Tg(tetO-cre)1Jaw/J 008244 FVB.Cg-Tg(tetO-cre)1Jaw/J 006224 STOCK Tg(tetO-cre)1Jaw/J View Strains carrying Tg(tetO-cre)1Jaw (3 strains)
Additional Web Information
Introduction to Cre-lox technology
Tet Expression Systems
Phenotype
Phenotype Information
assigned by genotype
The following phenotype relates to a compound genotype created using this strain.
Contact JAX® Services jaxservices@jax.org for customized breeding options.Tg(Scgb1a1-rtTA)2Jaw/0 Tg(tetO-cre)1Jaw/0
involves: 129 * C57BL/6 * FVB/N (conditional)
- mortality/aging
- *normal* mortality/aging
- doxycycline-treated mice do not exhibit perinatal toxicity (MGI Ref ID J:179352)
- respiratory system phenotype
- *normal* respiratory system phenotype
- doxycycline-treated mice do not exhibit lung pathology or dysfunction (MGI Ref ID J:179352)
- doxycycline-treated mice exhibit minimal focal airspace enlargement unlike Tg(Scgb1a1-rtTA)1Jaw mice (MGI Ref ID J:179352)
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System
Cre Recombinase Expression
Cre Recombinase Expression: Inducible
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Tetop Tet System
Tet Expression Systems
tTA/rtTA Responsive Strains
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(tetO-cre)1Jaw | ||
|---|---|---|---|
| Allele Name | transgene insertion 1, Jeffrey A Whitsett | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | (tetO)7-CMV-Cre; (tetO)7-CMV-Cretg; (tetO)7-Cre; (tetO)7CMV-Cretg; (tetO)7CMVtg; TRECre; tetO-cre; | ||
| Mutation Made By | Dr. Andras Nagy, Mount Sinai Hospital | ||
| Strain of Origin | 129 and C57BL/6 | ||
| Site of Expression | widespread, inducible expression of Cre recombinase | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | tetO, tet operator, | ||
| Gene Symbol and Name | Tg(tetO-cre)1Jaw, transgene insertion 1, Jeffrey A Whitsett | ||
| Chromosome | UN | ||
| Gene Common Name(s) | (tetO)7-CMV-Cre; (tetO)7-CMV-Cretg; (tetO)7-Cre; (tetO)7CMV-Cretg; (tetO)7CMVtg; TRECre; tetO-cre; | ||
| Driver Note | tetO | ||
| Inducible Note | Induced by doxycycline | ||
| Molecular Note | The transgene is composed of 7 tetO sites, a minimal CMV promoter, and sequence encoding cre recombinase. [MGI Ref ID J:78365] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre Melt Curve Analysis, Melt Curve Analysis
Generic Cre, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Perl AK; Wert SE; Nagy A; Lobe CG; Whitsett JA. 2002. Early restriction of peripheral and proximal cell lineages during formation of the lung. Proc Natl Acad Sci U S A 99(16):10482-7. [PubMed: 12145322] [MGI Ref ID J:78365]
Additional References
Tg(tetO-cre)1Jaw relatedAutry AE; Adachi M; Cheng P; Monteggia LM. 2009. Gender-specific impact of brain-derived neurotrophic factor signaling on stress-induced depression-like behavior. Biol Psychiatry 66(1):84-90. [PubMed: 19358977] [MGI Ref ID J:157287]
Balli D; Ustiyan V; Zhang Y; Wang IC; Masino AJ; Ren X; Whitsett JA; Kalinichenko VV; Kalin TV. 2013. Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition. EMBO J 32(2):231-44. [PubMed: 23288041] [MGI Ref ID J:193263]
Basseres DS; Levantini E; Ji H; Monti S; Elf S; Dayaram T; Fenyus M; Kocher O; Golub T; Wong KK; Halmos B; Tenen DG. 2006. Respiratory failure due to differentiation arrest and expansion of alveolar cells following lung-specific loss of the transcription factor C/EBPalpha in mice. Mol Cell Biol 26(3):1109-23. [PubMed: 16428462] [MGI Ref ID J:105593]
Berdnikovs S; Abdala-Valencia H; Cook-Mills JM. 2013. Endothelial cell PTP1B regulates leukocyte recruitment during allergic inflammation. Am J Physiol Lung Cell Mol Physiol 304(4):L240-9. [PubMed: 23275627] [MGI Ref ID J:194934]
Besnard V; Wert SE; Stahlman MT; Postle AD; Xu Y; Ikegami M; Whitsett JA. 2009. Deletion of Scap in alveolar type II cells influences lung lipid homeostasis and identifies a compensatory role for pulmonary lipofibroblasts. J Biol Chem 284(6):4018-30. [PubMed: 19074148] [MGI Ref ID J:147592]
Brechbuhl HM; Ghosh M; Smith MK; Smith RW; Li B; Hicks DA; Cole BB; Reynolds PR; Reynolds SD. 2011. beta-Catenin Dosage Is a Critical Determinant of Tracheal Basal Cell Fate Determination. Am J Pathol 179(1):367-79. [PubMed: 21703416] [MGI Ref ID J:173999]
Broide DH; Lawrence T; Doherty T; Cho JY; Miller M; McElwain K; McElwain S; Karin M. 2005. Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium. Proc Natl Acad Sci U S A 102(49):17723-8. [PubMed: 16317067] [MGI Ref ID J:104395]
Chapman HA; Li X; Alexander JP; Brumwell A; Lorizio W; Tan K; Sonnenberg A; Wei Y; Vu TH. 2011. Integrin alpha6beta4 identifies an adult distal lung epithelial population with regenerative potential in mice. J Clin Invest 121(7):2855-62. [PubMed: 21701069] [MGI Ref ID J:175915]
Chen C; Kudo M; Rutaganira F; Takano H; Lee C; Atakilit A; Robinett KS; Uede T; Wolters PJ; Shokat KM; Huang X; Sheppard D. 2012. Integrin alpha9beta1 in airway smooth muscle suppresses exaggerated airway narrowing. J Clin Invest 122(8):2916-27. [PubMed: 22772469] [MGI Ref ID J:190074]
Chen G; Korfhagen TR; Xu Y; Kitzmiller J; Wert SE; Maeda Y; Gregorieff A; Clevers H; Whitsett JA. 2009. SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. J Clin Invest 119(10):2914-24. [PubMed: 19759516] [MGI Ref ID J:154639]
Chen G; Wan H; Luo F; Zhang L; Xu Y; Lewkowich I; Wills-Karp M; Whitsett JA. 2010. Foxa2 programs Th2 cell-mediated innate immunity in the developing lung. J Immunol 184(11):6133-41. [PubMed: 20483781] [MGI Ref ID J:161217]
Chen H; Zhuang F; Liu YH; Xu B; Del Moral P; Deng W; Chai Y; Kolb M; Gauldie J; Warburton D; Moses HL; Shi W. 2008. TGF-beta receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung. Eur Respir J 32(2):285-95. [PubMed: 18321928] [MGI Ref ID J:137996]
Chen L; Meng Q; Kao W; Xia Y. 2011. IkappaB kinase beta regulates epithelium migration during corneal wound healing. PLoS One 6(1):e16132. [PubMed: 21264230] [MGI Ref ID J:180829]
Cho HC; Lai CY; Shao LE; Yu J. 2011. Identification of Tumorigenic Cells in KrasG12D-Induced Lung Adenocarcinoma. Cancer Res 71(23):7250-8. [PubMed: 22088965] [MGI Ref ID J:178608]
Dave V; Childs T; Xu Y; Ikegami M; Besnard V; Maeda Y; Wert SE; Neilson JR; Crabtree GR; Whitsett JA. 2006. Calcineurin/Nfat signaling is required for perinatal lung maturation and function. J Clin Invest 116(10):2597-609. [PubMed: 16998587] [MGI Ref ID J:114501]
Dave V; Wert SE; Tanner T; Thitoff AR; Loudy DE; Whitsett JA. 2008. Conditional deletion of Pten causes bronchiolar hyperplasia. Am J Respir Cell Mol Biol 38(3):337-45. [PubMed: 17921358] [MGI Ref ID J:146355]
Ding BS; Nolan DJ; Guo P; Babazadeh AO; Cao Z; Rosenwaks Z; Crystal RG; Simons M; Sato TN; Worgall S; Shido K; Rabbany SY; Rafii S. 2011. Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization. Cell 147(3):539-53. [PubMed: 22036563] [MGI Ref ID J:178690]
El-Hashash AH; Al Alam D; Turcatel G; Bellusci S; Warburton D. 2011. Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol 350(1):112-26. [PubMed: 21129374] [MGI Ref ID J:170236]
El-Hashash AH; Turcatel G; Al Alam D; Buckley S; Tokumitsu H; Bellusci S; Warburton D. 2011. Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium. Development 138(7):1395-407. [PubMed: 21385765] [MGI Ref ID J:171504]
Fong CH; Bebien M; Didierlaurent A; Nebauer R; Hussell T; Broide D; Karin M; Lawrence T. 2008. An antiinflammatory role for IKKbeta through the inhibition of 'classical' macrophage activation. J Exp Med 205(6):1269-76. [PubMed: 18490491] [MGI Ref ID J:137075]
Frank DU; Elliott SA; Park EJ; Hammond J; Saijoh Y; Moon AM. 2007. System for inducible expression of cre-recombinase from the Foxa2 locus in endoderm, notochord, and floor plate. Dev Dyn 236(4):1085-1092. [PubMed: 17304540] [MGI Ref ID J:119721]
Glaros S; Cirrincione GM; Palanca A; Metzger D; Reisman D. 2008. Targeted knockout of BRG1 potentiates lung cancer development. Cancer Res 68(10):3689-96. [PubMed: 18483251] [MGI Ref ID J:135031]
Goto J; Talos DM; Klein P; Qin W; Chekaluk YI; Anderl S; Malinowska IA; Di Nardo A; Bronson RT; Chan JA; Vinters HV; Kernie SG; Jensen FE; Sahin M; Kwiatkowski DJ. 2011. Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex. Proc Natl Acad Sci U S A 108(45):E1070-9. [PubMed: 22025691] [MGI Ref ID J:180260]
Greenwood KK; Proper SP; Saini Y; Bramble LA; Jackson-Humbles DN; Wagner JG; Harkema JR; LaPres JJ. 2012. Neonatal epithelial hypoxia inducible factor-1alpha expression regulates the response of the lung to experimental asthma. Am J Physiol Lung Cell Mol Physiol 302(5):L455-62. [PubMed: 22180657] [MGI Ref ID J:183445]
Hashimoto T; Bergen SE; Nguyen QL; Xu B; Monteggia LM; Pierri JN; Sun Z; Sampson AR; Lewis DA. 2005. Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia. J Neurosci 25(2):372-83. [PubMed: 15647480] [MGI Ref ID J:97675]
Heinonen KM; Vanegas JR; Brochu S; Shan J; Vainio SJ; Perreault C. 2011. Wnt4 regulates thymic cellularity through the expansion of thymic epithelial cells and early thymic progenitors. Blood 118(19):5163-73. [PubMed: 21937690] [MGI Ref ID J:178890]
Hill JJ; Kolluri N; Hashimoto T; Wu Q; Sampson AR; Monteggia LM; Lewis DA. 2005. Analysis of pyramidal neuron morphology in an inducible knockout of brain-derived neurotrophic factor. Biol Psychiatry 57(8):932-4. [PubMed: 15820715] [MGI Ref ID J:102119]
Hlady RA; Novakova S; Opavska J; Klinkebiel D; Peters SL; Bies J; Hannah J; Iqbal J; Anderson KM; Siebler HM; Smith LM; Greiner TC; Bastola D; Joshi S; Lockridge O; Simpson MA; Felsher DW; Wagner KU; Chan WC; Christman JK; Opavsky R. 2012. Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis. J Clin Invest 122(1):163-77. [PubMed: 22133874] [MGI Ref ID J:184415]
Hokuto I; Ikegami M; Yoshida M; Takeda K; Akira S; Perl AK; Hull WM; Wert SE; Whitsett JA. 2004. Stat-3 is required for pulmonary homeostasis during hyperoxia. J Clin Invest 113(1):28-37. [PubMed: 14702106] [MGI Ref ID J:87622]
Ihara S; Kida H; Arase H; Tripathi LP; Chen YA; Kimura T; Yoshida M; Kashiwa Y; Hirata H; Fukamizu R; Inoue R; Hasegawa K; Goya S; Takahashi R; Minami T; Tsujino K; Suzuki M; Kohmo S; Inoue K; Nagatomo I; Takeda Y; Kijima T; Mizuguchi K; Tachibana I; Kumanogoh A. 2012. Inhibitory roles of signal transducer and activator of transcription 3 in antitumor immunity during carcinogen-induced lung tumorigenesis. Cancer Res 72(12):2990-9. [PubMed: 22659452] [MGI Ref ID J:189293]
Ikegami M; Falcone A; Whitsett JA. 2008. STAT-3 regulates surfactant phospholipid homeostasis in normal lung and during endotoxin-mediated lung injury. J Appl Physiol 104(6):1753-60. [PubMed: 18369093] [MGI Ref ID J:183960]
Inoshima I; Inoshima N; Wilke GA; Powers ME; Frank KM; Wang Y; Bubeck Wardenburg J. 2011. A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice. Nat Med 17(10):1310-4. [PubMed: 21926978] [MGI Ref ID J:177286]
Inoue D; Kubo H; Taguchi K; Suzuki T; Komatsu M; Motohashi H; Yamamoto M. 2011. Inducible disruption of autophagy in the lung causes airway hyper-responsiveness. Biochem Biophys Res Commun 405(1):13-8. [PubMed: 21185264] [MGI Ref ID J:168468]
Kalin TV; Wang IC; Meliton L; Zhang Y; Wert SE; Ren X; Snyder J; Bell SM; Graf L Jr; Whitsett JA; Kalinichenko VV. 2008. Forkhead Box m1 transcription factor is required for perinatal lung function. Proc Natl Acad Sci U S A 105(49):19330-5. [PubMed: 19033457] [MGI Ref ID J:142246]
Kida H; Mucenski ML; Thitoff AR; Le Cras TD; Park KS; Ikegami M; Muller W; Whitsett JA. 2008. GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium. Am J Pathol 172(6):1542-54. [PubMed: 18467707] [MGI Ref ID J:136187]
Kim KK; Wei Y; Szekeres C; Kugler MC; Wolters PJ; Hill ML; Frank JA; Brumwell AN; Wheeler SE; Kreidberg JA; Chapman HA. 2009. Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest 119(1):213-24. [PubMed: 19104148] [MGI Ref ID J:144703]
Kimura T; Kawabe H; Jiang C; Zhang W; Xiang YY; Lu C; Salter MW; Brose N; Lu WY; Rotin D. 2011. Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease. Proc Natl Acad Sci U S A 108(8):3216-21. [PubMed: 21300902] [MGI Ref ID J:169296]
Kuperman DA; Huang X; Nguyenvu L; Holscher C; Brombacher F; Erle DJ. 2005. IL-4 receptor signaling in Clara cells is required for allergen-induced mucus production. J Immunol 175(6):3746-52. [PubMed: 16148120] [MGI Ref ID J:116729]
Le A; Zielinski R; He C; Crow MT; Biswal S; Tuder RM; Becker PM. 2009. Pulmonary epithelial neuropilin-1 deletion enhances development of cigarette smoke-induced emphysema. Am J Respir Crit Care Med 180(5):396-406. [PubMed: 19520907] [MGI Ref ID J:167963]
Li FF; Shen J; Shen HJ; Zhang X; Cao R; Zhang Y; Qui Q; Lin XX; Xie YC; Zhang LH; Jia YL; Dong XW; Jiang JX; Bao MJ; Zhang S; Ma WJ; Wu XM; Shen H; Xie QM; Ke Y. 2012. Shp2 plays an important role in acute cigarette smoke-mediated lung inflammation. J Immunol 189(6):3159-67. [PubMed: 22891281] [MGI Ref ID J:189811]
Lin C; Yin Y; Chen H; Fisher AV; Chen F; Rauchman M; Ma L. 2009. Construction and characterization of a doxycycline-inducible transgenic system in Msx2 expressing cells. Genesis 47(5):352-359. [PubMed: 19370755] [MGI Ref ID J:148502]
Lin C; Yin Y; Veith GM; Fisher AV; Long F; Ma L. 2009. Temporal and spatial dissection of Shh signaling in genital tubercle development. Development 136(23):3959-67. [PubMed: 19906863] [MGI Ref ID J:158288]
Liu Y; Sadikot RT; Adami GR; Kalinichenko VV; Pendyala S; Natarajan V; Zhao YY; Malik AB. 2011. FoxM1 mediates the progenitor function of type II epithelial cells in repairing alveolar injury induced by Pseudomonas aeruginosa. J Exp Med 208(7):1473-84. [PubMed: 21708928] [MGI Ref ID J:176807]
Liu Z; Obenauf AC; Speicher MR; Kopan R. 2009. Rapid identification of homologous recombinants and determination of gene copy number with reference/query pyrosequencing (RQPS). Genome Res 19(11):2081-9. [PubMed: 19797679] [MGI Ref ID J:172930]
Mannik J; Alzayady K; Ghazizadeh S. 2010. Regeneration of multilineage skin epithelia by differentiated keratinocytes. J Invest Dermatol 130(2):388-97. [PubMed: 19675579] [MGI Ref ID J:159578]
Manwani N; Gagnon S; Post M; Joza S; Muglia L; Cornejo S; Kaplan F; Sweezey NB. 2010. Reduced viability of mice with lung epithelial-specific knockout of glucocorticoid receptor. Am J Respir Cell Mol Biol 43(5):599-606. [PubMed: 20042713] [MGI Ref ID J:177810]
Martis PC; Whitsett JA; Xu Y; Perl AK; Wan H; Ikegami M. 2006. C/EBP{alpha} is required for lung maturation at birth. Development 133(6):1155-64. [PubMed: 16467360] [MGI Ref ID J:106543]
Mason-Richie NA; Mistry MJ; Gettler CA; Elayyadi A; Wikenheiser-Brokamp KA. 2008. Retinoblastoma function is essential for establishing lung epithelial quiescence after injury. Cancer Res 68(11):4068-76. [PubMed: 18519665] [MGI Ref ID J:136426]
Matsuzaki Y; Besnard V; Clark JC; Xu Y; Wert SE; Ikegami M; Whitsett JA. 2008. STAT3 regulates ABCA3 expression and influences lamellar body formation in alveolar type II cells. Am J Respir Cell Mol Biol 38(5):551-8. [PubMed: 18096869] [MGI Ref ID J:149721]
Matsuzaki Y; Xu Y; Ikegami M; Besnard V; Park KS; Hull WM; Wert SE; Whitsett JA. 2006. Stat3 is required for cytoprotection of the respiratory epithelium during adenoviral infection. J Immunol 177(1):527-37. [PubMed: 16785550] [MGI Ref ID J:134441]
Miller LA; Wert SE; Clark JC; Xu Y; Perl AK; Whitsett JA. 2004. Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung. Dev Dyn 231(1):57-71. [PubMed: 15305287] [MGI Ref ID J:91723]
Miller M; Tam AB; Cho JY; Doherty TA; Pham A; Khorram N; Rosenthal P; Mueller JL; Hoffman HM; Suzukawa M; Niwa M; Broide DH. 2012. ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6. Proc Natl Acad Sci U S A 109(41):16648-53. [PubMed: 23011799] [MGI Ref ID J:190332]
Minowada G; Miller YE. 2009. Overexpression of Sprouty 2 in mouse lung epithelium inhibits urethane-induced tumorigenesis. Am J Respir Cell Mol Biol 40(1):31-7. [PubMed: 18635814] [MGI Ref ID J:155786]
Monteggia LM; Barrot M; Powell CM; Berton O; Galanis V; Gemelli T; Meuth S; Nagy A; Greene RW; Nestler EJ. 2004. Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc Natl Acad Sci U S A 101(29):10827-32. [PubMed: 15249684] [MGI Ref ID J:91563]
Morimoto M; Kopan R. 2009. rtTA toxicity limits the usefulness of the SP-C-rtTA transgenic mouse. Dev Biol 325(1):171-8. [PubMed: 19013447] [MGI Ref ID J:143537]
Morimoto M; Liu Z; Cheng HT; Winters N; Bader D; Kopan R. 2010. Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate. J Cell Sci 123(Pt 2):213-24. [PubMed: 20048339] [MGI Ref ID J:156690]
Mucenski ML; Nation JM; Thitoff AR; Besnard V; Xu Y; Wert SE; Harada N; Taketo MM; Stahlman MT; Whitsett JA. 2005. Beta-catenin regulates differentiation of respiratory epithelial cells in vivo. Am J Physiol Lung Cell Mol Physiol 289(6):L971-9. [PubMed: 16040629] [MGI Ref ID J:105013]
Mucenski ML; Wert SE; Nation JM; Loudy DE; Huelsken J; Birchmeier W; Morrisey EE; Whitsett JA. 2003. beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis. J Biol Chem 278(41):40231-8. [PubMed: 12885771] [MGI Ref ID J:85946]
Nguyen NM; Kelley DG; Schlueter JA; Meyer MJ; Senior RM; Miner JH. 2005. Epithelial laminin alpha5 is necessary for distal epithelial cell maturation, VEGF production, and alveolization in the developing murine lung. Dev Biol 282(1):111-25. [PubMed: 15936333] [MGI Ref ID J:104565]
Opavsky R; Tsai SY; Guimond M; Arora A; Opavska J; Becknell B; Kaufmann M; Walton NA; Stephens JA; Fernandez SA; Muthusamy N; Felsher DW; Porcu P; Caligiuri MA; Leone G. 2007. Specific tumor suppressor function for E2F2 in Myc-induced T cell lymphomagenesis. Proc Natl Acad Sci U S A 104(39):15400-5. [PubMed: 17881568] [MGI Ref ID J:125304]
Opavsky R; Wang SH; Trikha P; Raval A; Huang Y; Wu YZ; Rodriguez B; Keller B; Liyanarachchi S; Wei G; Davuluri RV; Weinstein M; Felsher D; Ostrowski M; Leone G; Plass C. 2007. CpG island methylation in a mouse model of lymphoma is driven by the genetic configuration of tumor cells. PLoS Genet 3(9):1757-69. [PubMed: 17907813] [MGI Ref ID J:130029]
Ousset M; Van Keymeulen A; Bouvencourt G; Sharma N; Achouri Y; Simons BD; Blanpain C. 2012. Multipotent and unipotent progenitors contribute to prostate postnatal development. Nat Cell Biol 14(11):1131-8. [PubMed: 23064263] [MGI Ref ID J:193931]
Park KS; Wells JM; Zorn AM; Wert SE; Laubach VE; Fernandez LG; Whitsett JA. 2006. Transdifferentiation of ciliated cells during repair of the respiratory epithelium. Am J Respir Cell Mol Biol 34(2):151-7. [PubMed: 16239640] [MGI Ref ID J:120191]
Perl AK; Kist R; Shan Z; Scherer G; Whitsett JA. 2005. Normal lung development and function after Sox9 inactivation in the respiratory epithelium. Genesis 41(1):23-32. [PubMed: 15645446] [MGI Ref ID J:95910]
Perl AK; Wert SE; Loudy DE; Shan Z; Blair PA; Whitsett JA. 2005. Conditional recombination reveals distinct subsets of epithelial cells in trachea, bronchi, and alveoli. Am J Respir Cell Mol Biol 33(5):455-62. [PubMed: 16055670] [MGI Ref ID J:132772]
Perl AK; Zhang L; Whitsett JA. 2009. Conditional expression of genes in the respiratory epithelium in transgenic mice: cautionary notes and toward building a better mouse trap. Am J Respir Cell Mol Biol 40(1):1-3. [PubMed: 19075182] [MGI Ref ID J:179352]
Quinton LJ; Jones MR; Robson BE; Simms BT; Whitsett JA; Mizgerd JP. 2008. Alveolar epithelial STAT3, IL-6 family cytokines, and host defense during Escherichia coli pneumonia. Am J Respir Cell Mol Biol 38(6):699-706. [PubMed: 18192501] [MGI Ref ID J:149718]
Rabbani P; Takeo M; Chou W; Myung P; Bosenberg M; Chin L; Taketo MM; Ito M. 2011. Coordinated activation of wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration. Cell 145(6):941-55. [PubMed: 21663796] [MGI Ref ID J:173080]
Ren X; Shah TA; Ustiyan V; Zhang Y; Shinn J; Chen G; Whitsett JA; Kalin TV; Kalinichenko VV. 2013. FOXM1 promotes allergen-induced goblet cell metaplasia and pulmonary inflammation. Mol Cell Biol 33(2):371-86. [PubMed: 23149934] [MGI Ref ID J:194103]
Saini Y; Greenwood KK; Merrill C; Kim KY; Patial S; Parameswaran N; Harkema JR; LaPres JJ. 2010. Acute cobalt-induced lung injury and the role of hypoxia-inducible factor 1alpha in modulating inflammation. Toxicol Sci 116(2):673-81. [PubMed: 20511350] [MGI Ref ID J:162927]
Saini Y; Harkema JR; LaPres JJ. 2008. HIF1alpha is essential for normal intrauterine differentiation of alveolar epithelium and surfactant production in the newborn lung of mice. J Biol Chem 283(48):33650-7. [PubMed: 18801745] [MGI Ref ID J:143384]
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Sun J; Chen H; Chen C; Whitsett JA; Mishina Y; Bringas P Jr; Ma JC; Warburton D; Shi W. 2008. Prenatal lung epithelial cell-specific abrogation of alk3-bone morphogenetic protein signaling causes neonatal respiratory distress by disrupting distal airway formation. Am J Pathol 172(3):571-82. [PubMed: 18258849] [MGI Ref ID J:132011]
Takahashi H; Ogata H; Nishigaki R; Broide DH; Karin M. 2010. Tobacco Smoke Promotes Lung Tumorigenesis by Triggering IKKbeta- and JNK1-Dependent Inflammation. Cancer Cell 17(1):89-97. [PubMed: 20129250] [MGI Ref ID J:156928]
Tang W; Zeve D; Suh JM; Bosnakovski D; Kyba M; Hammer RE; Tallquist MD; Graff JM. 2008. White fat progenitor cells reside in the adipose vasculature. Science 322(5901):583-6. [PubMed: 18801968] [MGI Ref ID J:178521]
Teta M; Choi YS; Okegbe T; Wong G; Tam OH; Chong MM; Seykora JT; Nagy A; Littman DR; Andl T; Millar SE. 2012. Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skin. Development 139(8):1405-16. [PubMed: 22434867] [MGI Ref ID J:183487]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX11
Colony Maintenance
Mating System Noncarrier x Hemizygote (Female x Male) 11-OCT-08 Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $232.00 Female or Male Hemizygous for Tg(tetO-cre)1Jaw
Price per Pair (US dollars $) Pair Genotype $296.00 Hemizygous for Tg(tetO-cre)1Jaw x Noncarrier $296.00 Noncarrier x Hemizygous for Tg(tetO-cre)1Jaw Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $301.60 Female or Male Hemizygous for Tg(tetO-cre)1Jaw
Price per Pair (US dollars $) Pair Genotype $384.80 Hemizygous for Tg(tetO-cre)1Jaw x Noncarrier $384.80 Noncarrier x Hemizygous for Tg(tetO-cre)1Jaw Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
|
|
|
Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
JAX® Mice
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JAX® Services
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Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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Terms of Use
Terms of Use
General Terms and Conditions
For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
Contact information
General inquiries regarding Terms of UseContracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.