Strain Name:

LT/SvEiJ

Stock Number:

006252

Availability:

Repository- Live

Description

Strain Information

Type Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Type Inbred Strain;
Additional information on Inbred Strains.
Visit our online Nomenclature tutorial.
Mating SystemSibling x Sibling         (Female x Male)   12-FEB-09
Specieslaboratory mouse
H2 Haplotyped
GenerationF89+F85 (05-DEC-07)

Appearance
grey-brown
Related Genotype: Tyrp1B-lt/Tyrp1B-lt a/a

Development
This inbred strain began as a spontaneous mutation described as light (B-lt), it was discovered in a C58 colony by Dr. E. C. MacDowell in 1950. The affected light mouse was crossed to BALB and brother x sister mated for 7 generations. The colony was then transferred to Dr. Herman Chase and reached F28 by 1957. Chase sent the mice to Dr. E. S. Russell at The Jackson Laboratory in 1957. From Russell, the colony was transferred to Dr. S. E. Bernstein and in 1971 transferred to Dr. Leroy Stevens at the F75 (Stevens LC, et al., 1974 J:25361). Dr. Eva Eicher took over the colony from Dr. Stevens. It was imported into The Jackson Laboratory Repository in 2006.

Control Information

  Control
   None Available
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Tyrp1
000004   ABP/LeJ
000957   AKXD28/TyJ
000093   B6.B10(D1)-Tyrp1b-c/J
008684   B6.Cg-Rag1tm1Mom Tyrp1B-w Tg(Tcra,Tcrb)9Rest/J
000571   B6.Cg-Whrnwi Tyrp1b/+ +/J
000027   B6.D-Tyrp1b Dock7m/J
000068   C57BL/6J-Tyrp1b-J/J
000670   DBA/1J
000671   DBA/2J
000265   MY/HuLeJ
001045   SI/Col Tyrp1b Dnahc11iv/J
002142   STOCK 11R30m/J
000064   STOCK a Tyrp1b Sisi/J
002238   STOCK a Tyrp1b shmy/J
001432   STOCK a/a Tyrp1b sks/Tyrp1b +/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
001101   STOCK T(3;4)5Rk Tyrp1b/J
000274   TSJ/LeJ
View Strains carrying other alleles of Tyrp1     (18 strains)

Additional Web Information

Genetic Quality Control Annual Report

Phenotype

Phenotype Information

View Phenotypic Data

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

Tyrp1B-lt/Tyrp1B-lt

        LT/SvEiJ
  • pigmentation phenotype
  • abnormal iris pigmentation (MGI Ref ID J:141035)
    • iris pigmentation is dispersed
  • vision/eye phenotype
  • abnormal iris pigmentation (MGI Ref ID J:141035)
    • iris pigmentation is dispersed

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Tyrp1B-lt/Tyrp1B-lt

        Background Not Specified
  • hearing/vestibular/ear phenotype
  • abnormal ear morphology (MGI Ref ID J:16249)
    • abnormal inner ear morphology (MGI Ref ID J:16249)
      • abnormal strial intermediate cells (MGI Ref ID J:16249)
        • pigmentation is abundant as clumps in older mice
  • abnormal hearing physiology (MGI Ref ID J:16249)
    • abnormal endocochlear potential (MGI Ref ID J:16249)
      • loss of endocochlear potential correlates with loss of pigment
      • decreased endocochlear potential (MGI Ref ID J:16249)
        • potential is reduced to 19-59mV in 30% of two age groups: 2.5 to 4 mo and 1-2 years
        • loss of potential is correlated with loss of pigment with age
  • pigmentation phenotype
  • abnormal coat/hair pigmentation (MGI Ref ID J:16249)
    • pigment is lost as mice age
    • diluted coat color (MGI Ref ID J:1086)
      • base of hairs become lighter as more pigment is lost with age, older mice are pale grey in color
      • pigment loss is due to premature melanocyte death mediated by natural toxicity of pigment production
  • abnormal strial intermediate cells (MGI Ref ID J:16249)
    • pigmentation is abundant as clumps in older mice
  • skin/coat/nails phenotype
  • abnormal coat/hair pigmentation (MGI Ref ID J:16249)
    • pigment is lost as mice age
    • diluted coat color (MGI Ref ID J:1086)
      • base of hairs become lighter as more pigment is lost with age, older mice are pale grey in color
      • pigment loss is due to premature melanocyte death mediated by natural toxicity of pigment production

Tyrp1B-lt/Tyrp1B-lt

        involves: C57BL/6J
  • homeostasis/metabolism phenotype
  • increased bleeding time (MGI Ref ID J:7327)
    • bleed time of 5.7 minutes on average after tail nick is higher than the 3.8 minutes in C57BL/6J controls

The following phenotype relates to a compound genotype created using this strain.
Contact JAX® Services jaxservices@jax.org for customized breeding options.

a/a Tyrp1B-lt/Tyrp1B-lt

        Background Not Specified
  • pigmentation phenotype
  • abnormal dorsoventral coat patterning (MGI Ref ID J:13094)
    • the ventral hairs are substantially less pigmented than those of the dorsum
  • abnormal hair follicle melanin granule morphology (MGI Ref ID J:13094)
    • although in early stages of hair growth the granules are round and relatively uniform in size, in later stages they are larger, more variable in size, and some clumping is found
    • by the 9th day of a new hair growth cycle some hair bulbs are devoid of pigmentation and by 14 days very few follicles have active melanocytes
    • enlarged hair follicle melanin granules (MGI Ref ID J:13094)
  • abnormal hair shaft melanin granules (MGI Ref ID J:13094)
    • variation in the amount of pigmentation present in one hair shaft versus the next
    • variation in the size ans shape of pigment granules, with some instances of large masses of pigment in a particular hair shaft
    • abnormal hair shaft melanin granule distribution (MGI Ref ID J:13094)
      • hair shafts have large clumps of pigmented granules predominantly restricted to the medullary regions
      • decreased pigmentation in the hair shafts with age
    • reduced hair shaft melanin granule number (MGI Ref ID J:13094)
  • skin/coat/nails phenotype
  • abnormal dorsoventral coat patterning (MGI Ref ID J:13094)
    • the ventral hairs are substantially less pigmented than those of the dorsum
  • abnormal hair follicle melanin granule morphology (MGI Ref ID J:13094)
    • although in early stages of hair growth the granules are round and relatively uniform in size, in later stages they are larger, more variable in size, and some clumping is found
    • by the 9th day of a new hair growth cycle some hair bulbs are devoid of pigmentation and by 14 days very few follicles have active melanocytes
    • enlarged hair follicle melanin granules (MGI Ref ID J:13094)
  • abnormal hair shaft melanin granules (MGI Ref ID J:13094)
    • variation in the amount of pigmentation present in one hair shaft versus the next
    • variation in the size ans shape of pigment granules, with some instances of large masses of pigment in a particular hair shaft
    • abnormal hair shaft melanin granule distribution (MGI Ref ID J:13094)
      • hair shafts have large clumps of pigmented granules predominantly restricted to the medullary regions
      • decreased pigmentation in the hair shafts with age
    • reduced hair shaft melanin granule number (MGI Ref ID J:13094)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cancer Research
Increased Tumor Incidence
      Gonadal Tumors: ovarian
      Gonadal Tumors: ovarian teratomas

Reproductive Biology Research
Gonadal Tumors
      ovarian teratomas

Genes & Alleles

Gene & Allele Information

 
Allele Symbol Tyrp1B-lt
Allele Name light
Allele Type Spontaneous
Strain of OriginC58
Gene Symbol and Name Tyrp1, tyrosinase-related protein 1
Chromosome 4
Gene Common Name(s) B; CAS2; CATB; GP75; TRP; TRP-1; TRP1; TYRP; Tyrp; b; b-PROTEIN; brown; iris stromal atrophy; isa; tyrosinase-related protein;
Molecular Note A C-to-T transition at position 113 is predicted to result in an arginine to cysteine substitition at codon 38. [MGI Ref ID J:1086]

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Genotyping resources and troubleshooting

References

References

Additional References

Damjanov I; Katic V; Stevens LC. 1975. Ultrastructure of Ovarian Teratomas in LT mice Z Krebsforsch 83:261-7.  [MGI Ref ID J:27979]

MacDOWELL EC. 1950. 'Light'--a new mouse color. J Hered 41(2):35-6. [PubMed: 15415586]  [MGI Ref ID J:13061]

Stevens LC; Varnum DS. 1974. The development of teratomas from parthenogenetically activated ovarian mouse eggs. Dev Biol 37(2):369-80. [PubMed: 4826282]  [MGI Ref ID J:25361]

Tyrp1B-lt related

Anderson MG; Hawes NL; Trantow CM; Chang B; John SW. 2008. Iris phenotypes and pigment dispersion caused by genes influencing pigmentation. Pigment Cell Melanoma Res 21(5):565-78. [PubMed: 18715234]  [MGI Ref ID J:141035]

Cable J; Jackson IJ; Steel KP. 1993. Light (Blt), a mutation that causes melanocyte death, affects stria vascularis function in the mouse inner ear. Pigment Cell Res 6(4 Pt 1):215-25. [PubMed: 8248019]  [MGI Ref ID J:16249]

Jackson IJ; Chambers D; Rinchik EM; Bennett DC. 1990. Characterization of TRP-1 mRNA levels in dominant and recessive mutations at the mouse brown (b) locus. Genetics 126(2):451-9. [PubMed: 2245917]  [MGI Ref ID J:44436]

Johnson R; Jackson IJ. 1992. Light is a dominant mouse mutation resulting in premature cell death. Nat Genet 1(3):226-9. [PubMed: 1303241]  [MGI Ref ID J:1086]

MacDOWELL EC. 1950. 'Light'--a new mouse color. J Hered 41(2):35-6. [PubMed: 15415586]  [MGI Ref ID J:13061]

Markert CL; Silvers WK. 1956. The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse. Genetics 41(3):429-50. [PubMed: 17247639]  [MGI Ref ID J:12970]

Moore KJ; Swing DA; Copeland NG; Jenkins NA. 1990. Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations [published erratum appears in Genetics 1990 Sep;126(1):285] Genetics 125(2):421-30. [PubMed: 2379821]  [MGI Ref ID J:29467]

Novak EK; Hui SW; Swank RT. 1984. Platelet storage pool deficiency in mouse pigment mutations associated with seven distinct genetic loci. Blood 63(3):536-44. [PubMed: 6696991]  [MGI Ref ID J:7327]

Pierro LJ. 1963. Effects of the light mutation of mouse coat color on eye pigmentation. J Exp Zool 153:81-87. [PubMed: 14047421]  [MGI Ref ID J:13009]

Quevedo WC Jr.; Chase HB. 1958. An analysis of the light mutation of coat color in mice. J Morphol 102:329-345.  [MGI Ref ID J:13094]

Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York.  [MGI Ref ID J:78801]

Sweet SE; Quevedo WC Jr. 1968. Role of melanocyte morphology in pigmentation of mouse hair. Anat Rec 162(2):243-54. [PubMed: 5726144]  [MGI Ref ID J:5095]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           A1

Colony Maintenance

Mating SystemSibling x Sibling         (Female x Male)   12-FEB-09
Diet Information LabDiet® 5K52/5K67

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Weeks of AgePrice (US dollars $)Gender
Individual Mouse $92.30Female or Male

Additional Supply Details

Pricing for International shipping destinations View USA Canada and Mexico pricing
Weeks of AgePrice (US dollars $)Gender
Individual Mouse $120.00Female or Male

Additional Supply Details

Supply Details

Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement.
Supply Notes

Control Information

  Control
   None Available
 
  Considerations for Choosing Controls
  USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains.
  International - Control Pricing Information for Genetically Engineered Mutant Strains.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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