Strain Name:

LT/SvEiJ

Stock Number:

006252

Order this mouse

Availability:

Cryopreserved - Ready for recovery

The inbred strain LT carries the spontaneous coat color mutation light (Tyrp1B-lt). Females exhibit oocyte metaphase I arrest (a result of prolonged spindle assembly checkpoint activity), parthenogenesis, embryonic triploidy and ovarian teratomas.

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Type Inbred Strain;
Additional information on Inbred Strains.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
H2 Haplotyped
GenerationF89+86p+F2p
Generation Definitions
 
Donating Investigator Eva Eicher,   The Jackson Laboratory

Appearance
grey-brown
Related Genotype: Tyrp1B-lt/Tyrp1B-lt a/a

Description
LT is an inbred strain derived from a C58 mouse, which was outcrossed to BALB/c. LT carries the spontaneous coat color mutation light (B-lt), an arginine to cysteine substitution in tyrosinase-related protein 1 (Tyrp1). LT mice are characterized by a white hair shaft, brown hair tips and pigment dispersion in the iris of the eye. Approximately half of all females develop ovarian teratomas. Poor reproductive success in LT females is attributable to abnormalities in oocyte meiotic cell-cycle (specifically in the spindle assembly checkpoint), spontaneous parthenogenetic activation of oocytes, and the occasional occurrence of digynic triploidy.

Development
This inbred strain began as a spontaneous mutation described as light (B-lt), it was discovered in a C58 colony by Dr. E. C. MacDowell in 1950. The affected light mouse was crossed to BALB and brother x sister mated for 7 generations. The colony was then transferred to Dr. Herman Chase and reached F28 by 1957. Chase sent the mice to Dr. E. S. Russell at The Jackson Laboratory in 1957. From Russell, the colony was transferred to Dr. S. E. Bernstein and in 1971 transferred to Dr. Leroy Stevens at the F75 (Stevens LC, et al., 1974 J:25361). Dr. Eva Eicher took over the colony from Dr. Stevens. It was imported into The Jackson Laboratory Repository in 2006.

Control Information

  Control
   None Available
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Tyrp1B-lt allele
017764   B6Ei.LT-Y(IsXPAR;Y)Ei Tyrp1B-lt/EiJ
View Strains carrying   Tyrp1B-lt     (1 strain)

View Strains carrying other alleles of Tyrp1     (17 strains)

Phenotype

Phenotype Information

View Phenotypic Data

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Albinism, Oculocutaneous, Type III; OCA3   (TYRP1)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Tyrp1B-lt/Tyrp1B-lt

        LT/SvEiJ
  • pigmentation phenotype
  • abnormal iris pigmentation
    • iris pigmentation is dispersed   (MGI Ref ID J:141035)
  • vision/eye phenotype
  • abnormal iris pigmentation
    • iris pigmentation is dispersed   (MGI Ref ID J:141035)

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Tyrp1B-lt/Tyrp1B-lt

        Background Not Specified
  • hearing/vestibular/ear phenotype
  • abnormal ear morphology   (MGI Ref ID J:16249)
    • abnormal inner ear morphology   (MGI Ref ID J:16249)
      • abnormal strial intermediate cell morphology
        • pigmentation is abundant as clumps in older mice   (MGI Ref ID J:16249)
  • abnormal hearing physiology   (MGI Ref ID J:16249)
    • abnormal endocochlear potential
      • loss of endocochlear potential correlates with loss of pigment   (MGI Ref ID J:16249)
      • decreased endocochlear potential
        • potential is reduced to 19-59mV in 30% of two age groups: 2.5 to 4 mo and 1-2 years   (MGI Ref ID J:16249)
        • loss of potential is correlated with loss of pigment with age   (MGI Ref ID J:16249)
  • pigmentation phenotype
  • abnormal coat/hair pigmentation
    • pigment is lost as mice age   (MGI Ref ID J:16249)
    • diluted coat color
      • base of hairs become lighter as more pigment is lost with age, older mice are pale grey in color   (MGI Ref ID J:1086)
      • pigment loss is due to premature melanocyte death mediated by natural toxicity of pigment production   (MGI Ref ID J:1086)
  • abnormal strial intermediate cell morphology
    • pigmentation is abundant as clumps in older mice   (MGI Ref ID J:16249)
  • integument phenotype
  • abnormal coat/hair pigmentation
    • pigment is lost as mice age   (MGI Ref ID J:16249)
    • diluted coat color
      • base of hairs become lighter as more pigment is lost with age, older mice are pale grey in color   (MGI Ref ID J:1086)
      • pigment loss is due to premature melanocyte death mediated by natural toxicity of pigment production   (MGI Ref ID J:1086)

Tyrp1B-lt/Tyrp1B-lt

        involves: C57BL/6J
  • homeostasis/metabolism phenotype
  • increased bleeding time
    • bleed time of 5.7 minutes on average after tail nick is higher than the 3.8 minutes in C57BL/6J controls   (MGI Ref ID J:7327)

The following phenotype relates to a compound genotype created using this strain.
Contact JAX® Services jaxservices@jax.org for customized breeding options.

a/a Tyrp1B-lt/Tyrp1B-lt

        Background Not Specified
  • pigmentation phenotype
  • abnormal dorsoventral coat patterning
    • the ventral hairs are substantially less pigmented than those of the dorsum   (MGI Ref ID J:13094)
  • abnormal hair follicle melanin granule morphology
    • although in early stages of hair growth the granules are round and relatively uniform in size, in later stages they are larger, more variable in size, and some clumping is found   (MGI Ref ID J:13094)
    • by the 9th day of a new hair growth cycle some hair bulbs are devoid of pigmentation and by 14 days very few follicles have active melanocytes   (MGI Ref ID J:13094)
    • enlarged hair follicle melanin granules   (MGI Ref ID J:13094)
  • abnormal hair shaft melanin granule morphology
    • variation in the amount of pigmentation present in one hair shaft versus the next   (MGI Ref ID J:13094)
    • variation in the size ans shape of pigment granules, with some instances of large masses of pigment in a particular hair shaft   (MGI Ref ID J:13094)
    • abnormal hair shaft melanin granule distribution
      • hair shafts have large clumps of pigmented granules predominantly restricted to the medullary regions   (MGI Ref ID J:13094)
      • decreased pigmentation in the hair shafts with age   (MGI Ref ID J:13094)
    • reduced hair shaft melanin granule number   (MGI Ref ID J:13094)
  • integument phenotype
  • abnormal dorsoventral coat patterning
    • the ventral hairs are substantially less pigmented than those of the dorsum   (MGI Ref ID J:13094)
  • abnormal hair follicle melanin granule morphology
    • although in early stages of hair growth the granules are round and relatively uniform in size, in later stages they are larger, more variable in size, and some clumping is found   (MGI Ref ID J:13094)
    • by the 9th day of a new hair growth cycle some hair bulbs are devoid of pigmentation and by 14 days very few follicles have active melanocytes   (MGI Ref ID J:13094)
    • enlarged hair follicle melanin granules   (MGI Ref ID J:13094)
  • abnormal hair shaft melanin granule morphology
    • variation in the amount of pigmentation present in one hair shaft versus the next   (MGI Ref ID J:13094)
    • variation in the size ans shape of pigment granules, with some instances of large masses of pigment in a particular hair shaft   (MGI Ref ID J:13094)
    • abnormal hair shaft melanin granule distribution
      • hair shafts have large clumps of pigmented granules predominantly restricted to the medullary regions   (MGI Ref ID J:13094)
      • decreased pigmentation in the hair shafts with age   (MGI Ref ID J:13094)
    • reduced hair shaft melanin granule number   (MGI Ref ID J:13094)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cancer Research
Increased Tumor Incidence
      Gonadal Tumors
      Gonadal Tumors: ovarian
      Gonadal Tumors: ovarian teratomas

Reproductive Biology Research
Developmental Defects Affecting Gonads
      females only
      parthenogenic activation
Fertility Defects
      females only
Gonadal Tumors
      ovarian teratomas

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Ots1LT/Sv
Allele Name LT/Sv
Allele Type QTL
Strain of OriginLT/Sv
Gene Symbol and Name Ots1, ovarian teratoma susceptibility 1
Chromosome 6
Gene Common Name(s) Qst1;
Molecular Note This allele confers ovarian tumor susceptibility compared to C57BL/6J. [MGI Ref ID J:38481]
 
Allele Symbol Tyrp1B-lt
Allele Name light
Allele Type Spontaneous
Strain of OriginC58
Gene Symbol and Name Tyrp1, tyrosinase-related protein 1
Chromosome 4
Gene Common Name(s) B; CAS2; CATB; GP75; OCA3; TRP; TRP-1; TRP1; TYRP; Tyrp; b; b-PROTEIN; brown; iris stromal atrophy; isa; tyrosinase-related protein;
Molecular Note A C-to-T transition at position 113 is predicted to result in an arginine to cysteine substitition at codon 38. [MGI Ref ID J:1086]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Artzt K; Calo C; Pinheiro EN; DiMeo-Talento A; Tyson FL. 1987. Ovarian teratocarcinomas in LT/Sv mice carrying t-mutations. Dev Genet 8(1):1-9. [PubMed: 3502964]  [MGI Ref ID J:9377]

Ciemerych MA; Kubiak JZ. 1998. Cytostatic activity develops during meiosis I in oocytes of LT/Sv mice. Dev Biol 200(2):198-211. [PubMed: 9705227]  [MGI Ref ID J:49966]

Damjanov I; Katic V; Stevens LC. 1975. Ultrastructure of Ovarian Teratomas in LT mice Z Krebsforsch 83:261-7.  [MGI Ref ID J:27979]

Eppig JJ; Wigglesworth K; Varnum DS; Nadeau JH. 1996. Genetic regulation of traits essential for spontaneous ovarian teratocarcinogenesis in strain LT/Sv mice: aberrant meiotic cell cycle, oocyte activation, and parthenogenetic development. Cancer Res 56(21):5047-54. [PubMed: 8895763]  [MGI Ref ID J:36225]

Everett CA; Auchincloss CA; Kaufman MH; Abbott CM; West JD. 2004. Genetic influences on ovulation of primary oocytes in LT/Sv strain mice. Reproduction 128(5):565-571. [PubMed: 15509702]  [MGI Ref ID J:93219]

Hoffmann S; Krol M; Polanski Z. 2012. Spindle assembly checkpoint-related meiotic defect in oocytes from LT/Sv mice has cytoplasmic origin and diminishes in older females. Reproduction 144(3):331-8. [PubMed: 22736797]  [MGI Ref ID J:191602]

Hupalowska A; Kalaszczynska I; Hoffmann S; Tsurumi C; Kubiak JZ; Polanski Z; Ciemerych MA. 2008. Metaphase I arrest in LT/Sv mouse oocytes involves the spindle assembly checkpoint. Biol Reprod 79(6):1102-10. [PubMed: 18753610]  [MGI Ref ID J:145799]

Kaufman MH; Speirs S. 1987. The postimplantation development of spontaneous digynic triploid embryos in LT/Sv strain mice. Development 101(2):383-91. [PubMed: 3446479]  [MGI Ref ID J:147185]

Lee GH; Bugni JM; Obata M; Nishimori H; Ogawa K; Drinkwater NR. 1997. Genetic dissection of susceptibility to murine ovarian teratomas that originate from parthenogenetic oocytes. Cancer Res 57(4):590-3. [PubMed: 9044831]  [MGI Ref ID J:38481]

MacDOWELL EC. 1950. 'Light'--a new mouse color. J Hered 41(2):35-6. [PubMed: 15415586]  [MGI Ref ID J:13061]

Maciejewska Z; Polanski Z; Kisiel K; Kubiak JZ; Ciemerych MA. 2009. Spindle assembly checkpoint-related failure perturbs early embryonic divisions and reduces reproductive performance of LT/Sv mice. Reproduction 137(6):931-42. [PubMed: 19279200]  [MGI Ref ID J:150219]

Maleszewski M; Yanagimachi R. 1995. Spontaneous and sperm-induced activation of oocytes in LT/ Sv strain mice. Dev Growth Differ 37(6):679-685.  [MGI Ref ID J:30666]

Speirs S; Kaufman MH. 1990. Effect of maternal age on the incidence of digynic triploidy in LT/Sv strain mice: implications for the ovulation of primary and secondary oocytes in this strain. J Exp Zool 253(1):83-7. [PubMed: 2313244]  [MGI Ref ID J:147183]

Stevens LC; Varnum DS. 1974. The development of teratomas from parthenogenetically activated ovarian mouse eggs. Dev Biol 37(2):369-80. [PubMed: 4826282]  [MGI Ref ID J:25361]

Yoshida N; Amanai M; Fukui T; Kajikawa E; Brahmajosyula M; Iwahori A; Nakano Y; Shoji S; Diebold J; Hessel H; Huss R; Perry AC. 2007. Broad, ectopic expression of the sperm protein PLCZ1 induces parthenogenesis and ovarian tumours in mice. Development 134(21):3941-52. [PubMed: 17933795]  [MGI Ref ID J:126315]

Ots1LT/Sv related

Lee GH; Bugni JM; Obata M; Nishimori H; Ogawa K; Drinkwater NR. 1997. Genetic dissection of susceptibility to murine ovarian teratomas that originate from parthenogenetic oocytes. Cancer Res 57(4):590-3. [PubMed: 9044831]  [MGI Ref ID J:38481]

Tyrp1B-lt related

Anderson MG; Hawes NL; Trantow CM; Chang B; John SW. 2008. Iris phenotypes and pigment dispersion caused by genes influencing pigmentation. Pigment Cell Melanoma Res 21(5):565-78. [PubMed: 18715234]  [MGI Ref ID J:141035]

Cable J; Jackson IJ; Steel KP. 1993. Light (Blt), a mutation that causes melanocyte death, affects stria vascularis function in the mouse inner ear. Pigment Cell Res 6(4 Pt 1):215-25. [PubMed: 8248019]  [MGI Ref ID J:16249]

Jackson IJ; Chambers D; Rinchik EM; Bennett DC. 1990. Characterization of TRP-1 mRNA levels in dominant and recessive mutations at the mouse brown (b) locus. Genetics 126(2):451-9. [PubMed: 2245917]  [MGI Ref ID J:44436]

Johnson R; Jackson IJ. 1992. Light is a dominant mouse mutation resulting in premature cell death. Nat Genet 1(3):226-9. [PubMed: 1303241]  [MGI Ref ID J:1086]

MacDOWELL EC. 1950. 'Light'--a new mouse color. J Hered 41(2):35-6. [PubMed: 15415586]  [MGI Ref ID J:13061]

Markert CL; Silvers WK. 1956. The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse. Genetics 41(3):429-50. [PubMed: 17247639]  [MGI Ref ID J:12970]

Moore KJ; Swing DA; Copeland NG; Jenkins NA. 1990. Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations [published erratum appears in Genetics 1990 Sep;126(1):285] Genetics 125(2):421-30. [PubMed: 2379821]  [MGI Ref ID J:29467]

Novak EK; Hui SW; Swank RT. 1984. Platelet storage pool deficiency in mouse pigment mutations associated with seven distinct genetic loci. Blood 63(3):536-44. [PubMed: 6696991]  [MGI Ref ID J:7327]

Pierro LJ. 1963. Effects of the light mutation of mouse coat color on eye pigmentation. J Exp Zool 153:81-87. [PubMed: 14047421]  [MGI Ref ID J:13009]

Quevedo WC Jr.; Chase HB. 1958. An analysis of the light mutation of coat color in mice. J Morphol 102:329-345.  [MGI Ref ID J:13094]

Silvers WK. 1979. The Coat Colors of Mice; A Model for Mammalian Gene Action and Interaction. In: The Coat Colors of Mice. Springer-Verlag, New York.  [MGI Ref ID J:78801]

Sweet SE; Quevedo WC Jr. 1968. Role of melanocyte morphology in pigmentation of mouse hair. Anat Rec 162(2):243-54. [PubMed: 5726144]  [MGI Ref ID J:5095]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryThis strain is susceptible to kidney disease and the females are prone to ovarian teratomas. Replace breeder pair after their fourth litter.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

General Supply Notes

  • View the complete collection of spontaneous mutants in the Mouse Mutant Resource.

Control Information

  Control
   None Available
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.6)