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Strain Name:

LT/SvEiJ

Stock Number:

006252

Availability:

Under Development for Cryopreservation Repository

To register your interest in this strain go to the Strain Interest Form.

Price and Supply Information

General Terms and Conditions

Genes & Alleles   Tyrp1;   Tyrp1B-lt;

Product Information

Strain Details

Type Inbred Strain
Additional information on Inbred Strains.
Type JAX® GEMM® Strain - Spontaneous Mutation
Additional information on JAX® GEMM® Strains.
Specieslaboratory mouse
H2 Haplotyped
GenerationF89+F85 (05-DEC-07)

Appearance
grey-brown
Related Genotype: Tyrp1B-lt/Tyrp1B-lt a/a

Strain Development
This inbred strain began as a spontaneous mutation described as light (B-lt), it was discovered in a C58 colony by Dr. E. C. MacDowell in 1950. The affected light mouse was crossed to BALB and brother x sister mated for 7 generations. The colony was then transferred to Dr. Herman Chase and reached F28 by 1957. Chase sent the mice to Dr. E. S. Russell at The Jackson Laboratory in 1957. From Russell, the colony was transferred to Dr. S. E. Bernstein and in 1971 transferred to Dr. Leroy Stevens at the F75 (Stevens LC, et al., 1974 J:25361). Dr. Eva Eicher took over the colony from Dr. Stevens. It was imported into The Jackson Laboratory Repository in 2006.

Mammalian Phenotype Terms assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Tyrp1B-lt/Tyrp1B-lt

        Background Not Specified
  • hearing/vestibular/ear phenotype
  • abnormal ear morphology (MGI Ref ID J:16249)
    • abnormal inner ear morphology (MGI Ref ID J:16249)
      • abnormal strial intermediate cells (MGI Ref ID J:16249)
        • pigmentation is abundant as clumps in older mice
  • abnormal hearing physiology (MGI Ref ID J:16249)
    • abnormal endocochlear potential (MGI Ref ID J:16249)
      • loss of endocochlear potential correlates with loss of pigment
      • decreased endocochlear potential (MGI Ref ID J:16249)
        • potential is reduced to 19-59mV in 30% of two age groups: 2.5 to 4 mo and 1-2 years
        • loss of potential is correlated with loss of pigment with age
  • pigmentation phenotype
  • abnormal coat color (MGI Ref ID J:16249)
    • pigment is lost as mice age
    • diluted coat color (MGI Ref ID J:1086)
      • base of hairs become lighter as more pigment is lost with age, older mice are pale grey in color
      • pigment loss is due to premature melanocyte death mediated by natural toxicity of pigment production
  • abnormal strial intermediate cells (MGI Ref ID J:16249)
    • pigmentation is abundant as clumps in older mice
  • skin/coat/nails phenotype
  • abnormal coat color (MGI Ref ID J:16249)
    • pigment is lost as mice age
    • diluted coat color (MGI Ref ID J:1086)
      • base of hairs become lighter as more pigment is lost with age, older mice are pale grey in color
      • pigment loss is due to premature melanocyte death mediated by natural toxicity of pigment production

The following phenotype relates to a compound genotype created using this strain.
Contact JAX® Services jaxservices@jax.org for customized breeding options.

a/a Tyrp1B-lt/Tyrp1B-lt

        Background Not Specified
  • pigmentation phenotype
  • abnormal dorsoventral coat patterning (MGI Ref ID J:13094)
    • the ventral hairs are substantially less pigmented than those of the dorsum
  • abnormal hair follicle melanin granule (MGI Ref ID J:13094)
    • although in early stages of hair growth the granules are round and relatively uniform in size, in later stages they are larger, more variable in size, and some clumping is found
    • by the 9th day of a new hair growth cycle some hair bulbs are devoid of pigmentation and by 14 days very few follicles have active melanocytes
    • enlarged melanin granules in hair follicle (MGI Ref ID J:13094)
  • abnormal hair shaft melanin granules (MGI Ref ID J:13094)
    • variation in the amount of pigmentation present in one hair shaft versus the next
    • variation in the size ans shape of pigment granules, with some instances of large masses of pigment in a particular hair shaft
    • abnormal hair shaft melanin granule distribution (MGI Ref ID J:13094)
      • hair shafts have large clumps of pigmented granules predominantly restricted to the medullary regions
      • decreased pigmentation in the hair shafts with age
    • reduced hair shaft melanin granule number (MGI Ref ID J:13094)
  • skin/coat/nails phenotype
  • abnormal dorsoventral coat patterning (MGI Ref ID J:13094)
    • the ventral hairs are substantially less pigmented than those of the dorsum
  • abnormal hair follicle melanin granule (MGI Ref ID J:13094)
    • although in early stages of hair growth the granules are round and relatively uniform in size, in later stages they are larger, more variable in size, and some clumping is found
    • by the 9th day of a new hair growth cycle some hair bulbs are devoid of pigmentation and by 14 days very few follicles have active melanocytes
    • enlarged melanin granules in hair follicle (MGI Ref ID J:13094)
  • abnormal hair shaft melanin granules (MGI Ref ID J:13094)
    • variation in the amount of pigmentation present in one hair shaft versus the next
    • variation in the size ans shape of pigment granules, with some instances of large masses of pigment in a particular hair shaft
    • abnormal hair shaft melanin granule distribution (MGI Ref ID J:13094)
      • hair shafts have large clumps of pigmented granules predominantly restricted to the medullary regions
      • decreased pigmentation in the hair shafts with age
    • reduced hair shaft melanin granule number (MGI Ref ID J:13094)

Gene & Allele Details

Allele Symbol Tyrp1B-lt
Allele Name light
Strain of OriginC58
Gene Symbol and Name Tyrp1, tyrosinase-related protein 1
Chromosome 4
Gene Common Name(s) B; CAS2; CATB; GP75; TRP; TRP-1; TRP1; TYRP; Tyrp; b; b-PROTEIN; brown; iris stromal atrophy; isa; tyrosinase-related protein;
Molecular Note A C-to-T transition at position 113 is predicted to result in an arginine to cysteine substitition at codon 38. [MGI Ref ID J:1086]

Control Information

  Control
   None Available
 
  Considerations for Choosing Controls
  Control Pricing Information for JAX® GEMM® Strains

Colony Maintenance

Diet Information LabDiet® 5K52/5K67

Related Strains

LT Strain
003588   LT/SvEi
View LT Strain     (1 strain)

Strains carrying   Tyrp1B-lt allele
003588   LT/SvEi
View Strains carrying   Tyrp1B-lt     (1 strain)

Strains carrying other alleles of Tyrp1
000004   ABP/LeJ
000571   B6.Cg-Whrnwi Tyrp1b/+ +/J
000027   B6.D-Tyrp1b m/J
000068   C57BL/6J-Tyrp1b-J/J
000093   C57BL/6J-Tyrp1b-cJ/J
000670   DBA/1J
000671   DBA/2J
000265   MY/HuLeJ
001045   SI/Col Tyrp1b Dnahc11iv/J
002142   STOCK 11R30m/J
000064   STOCK a Tyrp1b Sisi/J
002238   STOCK a Tyrp1b shmy/J
001432   STOCK a/a Tyrp1b sks/Tyrp1b +/J
000594   STOCK T(2;8)26H a/T(2;8)26H a Tyrp1+/Tyrp1b/J
001101   STOCK T(3;4)5Rk Tyrp1b/J
000274   TSJ/LeJ
View Strains carrying other alleles of Tyrp1     (16 strains)

Phenotypic Data

Festing Inbred Strain Characteristics: LT

Additional Web Information

Genetic Quality Control Annual Report

Research Applications

This mouse can be used to support research in many areas including:

Cancer Research
Increased Tumor Incidence (Gonadal Tumors: ovarian teratomas)
Increased Tumor Incidence (Gonadal Tumors: ovarian)

Reproductive Biology Research
Gonadal Tumors (ovarian teratomas)

References

Additional References

Price and Supply Information

Strain Name: LT/SvEiJ
Stock Number: 006252
 

This strain is currently Under Development for Cryopreservation Repository.
To register your interest in this strain go to the Strain Interest Form.

Estimated Available for Sale Date:

Please note: Estimated available for sale dates are provided to keep customers better informed on strains under development. Please note that our Colony Managers routinely monitor the target date and edit it based on breeding performance and other factors. The length of time it takes to make a new strain available for sale depends on genotype, age, number of animals sent by the Donating Investigator, breeding performance, additional strain development (backcrossing, making homozygous), and anticipated demand for the strain/interest registered.

View All Strains Under Development

Supply Details

Standard SupplyUnder Development for Cryopreservation Repository
Supply Notes This strain is included in the Mouse Mutant Resource collection.
Supply Notes Genomic DNA is available for this strain from the Mouse DNA Resource.
LicensingSee General Terms and Conditions below  
Control InformationView Control Information in Strain Details.
View Control Pricing Information for JAX® Strains.

General Terms and Conditions

View JAX® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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