Strain Name:

B6;129-Baxtm2Sjk Bak1tm1Thsn/J

Stock Number:

006329

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Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Mutant Stock; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
 
Donating InvestigatorDr. Stanley J. Korsmeyer,   Dana-Farber Cancer Institute

Description
Mice homozygous for both alleles (Baxfl and bak-) are viable and fertile with no reported abnormalities. Splenic and thymic tissues display no Bak1 protein expression.

When bred to Cre recombinase expressing mice, the resulting offspring will have exons 2-4 of Bax deleted in the cre-expressing tissues (determined by promoter driving cre expression). The conditional deletion of Bax combined with the Bak1 null allele makes these mice useful in studies of apoptosis regulation, tissue homeostasis, and development in multiple cell lineages.

When bred to a strain with a Bak1 targeted null allele (Stock No. 004183) and to either a strain with a Cd19 null allele and expressing Cre recombinase during the B lymphocyte development (Stock No. 004126) or to a strain expressing interferon inducible Cre recombinase (Stock No. 003556), this mutant mouse strain may be useful in studies of autoimmune disease.

Development
These mutant mice have targeted mutations of Bax and Bak1. For targeted mutation of Bax, Dr. Stanley J. Korsmeyer's lab (Harvard Medical School) designed a vector to flank exons 2-4 with loxP sites. This construct was electroporated into 129X1/SvJ-derived RW4 embryonic stem (ES) cells. Mice resulting from germline transmission of this Baxfl allele (on a mixed B6;129 genetic background) were generated. For targeted mutation of Bak1, Dr. Craig B. Thompson's lab (University of Pennsylvania) designed a vector to replace exons 3-6 (encoding the Bcl2 homology domains) with a neo cassette. This construct was electroporated into (129X1/SvJ x 129S1/Sv)F1-derived R1 ES cells. Mice resulting from germline transmission of this allele (on a mixed B6;129 genetic background) were generated. These two mutant strains were bred together and maintained as homozygotes by Dr. Stanley J. Korsmeyer's lab (Harvard Medical School) prior to arrival at The Jackson Laboratory.

Control Information

  Control
   101043 B6129SF1/J (approximate)
   101045 B6129SF2/J (approximate)
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Bak1tm1Thsn allele
004183   B6.129-Bak1tm1Thsn/J
View Strains carrying   Bak1tm1Thsn     (1 strain)

Strains carrying other alleles of Bax
002994   B6.129X1-Baxtm1Sjk/J
View Strains carrying other alleles of Bax     (1 strain)

Additional Web Information

Introduction to Cre-lox technology

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype relates to a compound genotype created using this strain.
Contact JAX® Services jaxservices@jax.org for customized breeding options.

Bak1tm1Thsn/Bak1tm1Thsn Baxtm1Sjk/Baxtm2Sjk Cd19tm1(cre)Cgn/Cd19+

        involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ   (conditional)
  • immune system phenotype
  • abnormal B cell number   (MGI Ref ID J:100463)
    • decreased marginal zone B cell number
      • relative number of CD21highCD23low marginal zone B cells is decreased   (MGI Ref ID J:100463)
    • increased B cell number
      • increase in the number of B cells at all stages of development in the bone marrow and spleen of transitional B cells, an increase in CD21intCD23high follicular B cells and B-2 cells, but not B-1 cells, from the peritoneal cavity   (MGI Ref ID J:100463)
      • increased B-2 B cell number
        • an increase in B-2 cell number, but not B-1 cells, from the peritoneal cavity   (MGI Ref ID J:100463)
      • increased follicular B cell number
        • an increase in CD21intCD23high follicular B cells   (MGI Ref ID J:100463)
      • increased pre-B cell number
        • a 4-fold increase in the number of IgM+ immature B cells   (MGI Ref ID J:100463)
      • increased transitional stage B cell number
        • a 3-5 fold increase in the numbers of transitional B cells   (MGI Ref ID J:100463)
  • abnormal B cell physiology
    • B cells are highly resistant to multiple cell death stimuli, including cytokine withdrawal, BCR crosslinking, steroid treatment, and DNA damage   (MGI Ref ID J:100463)
    • cell cycle progression of splenic B cells is impaired after stimulation with mitogens LPS and anti-IgM, but not CpG-DNA   (MGI Ref ID J:100463)
    • increased immunoglobulin level
      • all isotypes were 5-10 times higher than controls   (MGI Ref ID J:100463)
      • increased IgA level   (MGI Ref ID J:100463)
      • increased IgG level
        • increased IgG1, IgG2, IgG2b and IgG3   (MGI Ref ID J:100463)
      • increased IgM level   (MGI Ref ID J:100463)
  • increased pro-B cell number
    • 4-fold increase in the number of CD43+IgM- Pro-B cells   (MGI Ref ID J:100463)
  • hematopoietic system phenotype
  • abnormal B cell number   (MGI Ref ID J:100463)
    • decreased marginal zone B cell number
      • relative number of CD21highCD23low marginal zone B cells is decreased   (MGI Ref ID J:100463)
    • increased B cell number
      • increase in the number of B cells at all stages of development in the bone marrow and spleen of transitional B cells, an increase in CD21intCD23high follicular B cells and B-2 cells, but not B-1 cells, from the peritoneal cavity   (MGI Ref ID J:100463)
      • increased B-2 B cell number
        • an increase in B-2 cell number, but not B-1 cells, from the peritoneal cavity   (MGI Ref ID J:100463)
      • increased follicular B cell number
        • an increase in CD21intCD23high follicular B cells   (MGI Ref ID J:100463)
      • increased pre-B cell number
        • a 4-fold increase in the number of IgM+ immature B cells   (MGI Ref ID J:100463)
      • increased transitional stage B cell number
        • a 3-5 fold increase in the numbers of transitional B cells   (MGI Ref ID J:100463)
  • abnormal B cell physiology
    • B cells are highly resistant to multiple cell death stimuli, including cytokine withdrawal, BCR crosslinking, steroid treatment, and DNA damage   (MGI Ref ID J:100463)
    • cell cycle progression of splenic B cells is impaired after stimulation with mitogens LPS and anti-IgM, but not CpG-DNA   (MGI Ref ID J:100463)
    • increased immunoglobulin level
      • all isotypes were 5-10 times higher than controls   (MGI Ref ID J:100463)
      • increased IgA level   (MGI Ref ID J:100463)
      • increased IgG level
        • increased IgG1, IgG2, IgG2b and IgG3   (MGI Ref ID J:100463)
      • increased IgM level   (MGI Ref ID J:100463)
  • increased bone marrow cell number
    • 2-fold increase in total cellularity of bone marrow cells, due to accumulation of developing B cells   (MGI Ref ID J:100463)
  • increased pro-B cell number
    • 4-fold increase in the number of CD43+IgM- Pro-B cells   (MGI Ref ID J:100463)

Bak1tm1Thsn/Bak1tm1Thsn Baxtm1Sjk/Baxtm2Sjk Tg(Mx1-cre)1Cgn/0

        involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA   (conditional)
  • mortality/aging
  • premature death
    • by 35 weeks after induction of Cre expression (and thus Bax deletion) in the adult, 78% of mutants die compared to 5% of wild-type   (MGI Ref ID J:100463)
  • immune system phenotype
  • abnormal T cell differentiation
    • thymic T cell development is perturbed after poly(I:C) injection   (MGI Ref ID J:100463)
  • arthritis
    • develops after poly(I:C) injection to induce Bax deletion in the adult   (MGI Ref ID J:100463)
  • glomerulonephritis
    • develops after poly(I:C) injection to induce Bax deletion in the adult   (MGI Ref ID J:100463)
  • increased anti-double stranded DNA antibody level
    • show elevated serum antinuclear antibodies and anti-dsDNA antibody after 30 weeks of poly(I:C) injection to induce Bax deletion in the adult   (MGI Ref ID J:100463)
  • increased leukocyte cell number
    • accumulation of white blood cells after injection of poly(I:C) to induce Cre expression in adult   (MGI Ref ID J:100463)
    • increased lymphocyte cell number   (MGI Ref ID J:100463)
      • increased B cell number
        • exhibit accumulation of B cells in the spleen and bone marrow 6 weeks after poly(I:C) injection to induce Cre expression   (MGI Ref ID J:100463)
  • increased susceptibility to autoimmune disorder
    • develop autoimmune disease after poly(I:C) injection to induce Bax deletion in the adult   (MGI Ref ID J:100463)
  • hematopoietic system phenotype
  • abnormal T cell differentiation
    • thymic T cell development is perturbed after poly(I:C) injection   (MGI Ref ID J:100463)
  • increased leukocyte cell number
    • accumulation of white blood cells after injection of poly(I:C) to induce Cre expression in adult   (MGI Ref ID J:100463)
    • increased lymphocyte cell number   (MGI Ref ID J:100463)
      • increased B cell number
        • exhibit accumulation of B cells in the spleen and bone marrow 6 weeks after poly(I:C) injection to induce Cre expression   (MGI Ref ID J:100463)
  • renal/urinary system phenotype
  • glomerulonephritis
    • develops after poly(I:C) injection to induce Bax deletion in the adult   (MGI Ref ID J:100463)
  • skeleton phenotype
  • arthritis
    • develops after poly(I:C) injection to induce Bax deletion in the adult   (MGI Ref ID J:100463)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Apoptosis Research
Endogenous Regulators

Developmental Biology Research
Lymphoid Tissue Defects
      hematopoietic defects

Hematological Research
Hematopoietic Defects

Immunology, Inflammation and Autoimmunity Research
Lymphoid Tissue Defects
      hematopoietic development

Research Tools
Apoptosis Research
Cre-lox System
      loxP-flanked Sequences
Immunology, Inflammation and Autoimmunity Research

Bak1tm1Thsn related

Developmental Biology Research

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Bak1tm1Thsn
Allele Name targeted mutation 1, Craig B Thompson
Allele Type Targeted (Null/Knockout)
Common Name(s) bak-;
Mutation Made By Craig Thompson,   Memorial Sloan Kettering Cancer Center
Strain of Origin(129X1/SvJ x 129S1/Sv)F1-Kitl<+>
ES Cell Line NameR1
ES Cell Line Strain(129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Gene Symbol and Name Bak1, BCL2-antagonist/killer 1
Chromosome 17
Gene Common Name(s) BAK; BAK-LIKE; BCL2L7; CDN1; N-Bak;
Molecular Note A neomycin resistance cassette replaced a genomic fragment containing exons 2-6. These exons encode the Bcl-2 homology domains of the encoded protein. Western blot analysis on spleen and thymus lysates derived from homozygous mice confirmed that no detectable protein is expressed from this allele. [MGI Ref ID J:66872]
 
Allele Symbol Baxtm2Sjk
Allele Name targeted mutation 2, Stanley J Korsmeyer
Allele Type Targeted (Conditional ready (e.g. floxed), No functional change)
Common Name(s) Baxfl;
Strain of Origin129X1/SvJ
ES Cell Line NameRW-4
ES Cell Line Strain129X1/SvJ
Gene Symbol and Name Bax, BCL2-associated X protein
Chromosome 7
Gene Common Name(s) BCL2L4;
Molecular Note LoxP sites were inserted to flank exons 2-4. A loxP-flanked neo was removed via cre-mediated recombination. [MGI Ref ID J:100463]

Genotyping

Genotyping Information

Genotyping Protocols

Baxtm2Sjk STD PCR, Standard PCR
Bak1tm1Thsn, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Takeuchi O; Fisher J; Suh H; Harada H; Malynn BA; Korsmeyer SJ. 2005. Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. Proc Natl Acad Sci U S A 102(32):11272-7. [PubMed: 16055554]  [MGI Ref ID J:100463]

Additional References

Bak1tm1Thsn related

Akhtar RS; Geng Y; Klocke BJ; Roth KA. 2006. Neural precursor cells possess multiple p53-dependent apoptotic pathways. Cell Death Differ 13(10):1727-39. [PubMed: 16514420]  [MGI Ref ID J:126291]

Baines CP; Kaiser RA; Sheiko T; Craigen WJ; Molkentin JD. 2007. Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death. Nat Cell Biol 9(5):550-5. [PubMed: 17417626]  [MGI Ref ID J:129616]

Billen LP; Kokoski CL; Lovell JF; Leber B; Andrews DW. 2008. Bcl-XL inhibits membrane permeabilization by competing with Bax. PLoS Biol 6(6):e147. [PubMed: 18547146]  [MGI Ref ID J:139497]

Biswas S; Shi Q; Matise L; Cleveland S; Dave U; Zinkel S. 2010. A role for proapoptotic Bax and Bak in T-cell differentiation and transformation. Blood 116(24):5237-46. [PubMed: 20813900]  [MGI Ref ID J:167419]

Cammas L; Wolfe J; Choi SY; Dedhar S; Beggs HE. 2012. Integrin-linked kinase deletion in the developing lens leads to capsule rupture, impaired fiber migration and non-apoptotic epithelial cell death. Invest Ophthalmol Vis Sci 53(6):3067-81. [PubMed: 22491404]  [MGI Ref ID J:196836]

Campbell S; Hazes B; Kvansakul M; Colman P; Barry M. 2010. Vaccinia virus F1L interacts with Bak using highly divergent Bcl-2 homology domains and replaces the function of Mcl-1. J Biol Chem 285(7):4695-708. [PubMed: 19955184]  [MGI Ref ID J:160040]

Chao JR; Parganas E; Boyd K; Hong CY; Opferman JT; Ihle JN. 2008. Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons. Nature 452(7183):98-102. [PubMed: 18288109]  [MGI Ref ID J:132627]

Chen M; Felix K; Wang J. 2011. Immune regulation through mitochondrion-dependent dendritic cell death induced by T regulatory cells. J Immunol 187(11):5684-92. [PubMed: 22031758]  [MGI Ref ID J:179762]

Chen SK; Chew KS; McNeill DS; Keeley PW; Ecker JL; Mao BQ; Pahlberg J; Kim B; Lee SC; Fox MA; Guido W; Wong KY; Sampath AP; Reese BE; Kuruvilla R; Hattar S. 2013. Apoptosis regulates ipRGC spacing necessary for rods and cones to drive circadian photoentrainment. Neuron 77(3):503-15. [PubMed: 23395376]  [MGI Ref ID J:197847]

Cleland MM; Norris KL; Karbowski M; Wang C; Suen DF; Jiao S; George NM; Luo X; Li Z; Youle RJ. 2011. Bcl-2 family interaction with the mitochondrial morphogenesis machinery. Cell Death Differ 18(2):235-47. [PubMed: 20671748]  [MGI Ref ID J:186336]

Coultas L; Bouillet P; Loveland KL; Meachem S; Perlman H; Adams JM; Strasser A. 2005. Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis. EMBO J 24(22):3963-73. [PubMed: 16270031]  [MGI Ref ID J:103605]

Crowther AJ; Gama V; Bevilacqua A; Chang SX; Yuan H; Deshmukh M; Gershon TR. 2013. Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma. J Neurosci 33(46):18098-108. [PubMed: 24227720]  [MGI Ref ID J:204171]

Dansen TB; Whitfield J; Rostker F; Brown-Swigart L; Evan GI. 2006. Specific requirement for Bax, not Bak, in Myc-induced apoptosis and tumor suppression in vivo. J Biol Chem 281(16):10890-5. [PubMed: 16464852]  [MGI Ref ID J:108676]

Degenhardt K; Sundararajan R; Lindsten T; Thompson C; White E. 2002. Bax and Bak independently promote cytochrome C release from mitochondria. J Biol Chem 277(16):14127-34. [PubMed: 11836241]  [MGI Ref ID J:76058]

Di Paolo NC; Doronin K; Baldwin LK; Papayannopoulou T; Shayakhmetov DM. 2013. The Transcription Factor IRF3 Triggers "Defensive Suicide" Necrosis in Response to Viral and Bacterial Pathogens. Cell Rep 3(6):1840-6. [PubMed: 23770239]  [MGI Ref ID J:199310]

Doan PL; Himburg HA; Helms K; Russell JL; Fixsen E; Quarmyne M; Harris JR; Deoliviera D; Sullivan JM; Chao NJ; Kirsch DG; Chute JP. 2013. Epidermal growth factor regulates hematopoietic regeneration after radiation injury. Nat Med 19(3):295-304. [PubMed: 23377280]  [MGI Ref ID J:196315]

Doan PL; Russell JL; Himburg HA; Helms K; Harris JR; Lucas J; Holshausen KC; Meadows SK; Daher P; Jeffords LB; Chao NJ; Kirsch DG; Chute JP. 2013. Tie2(+) bone marrow endothelial cells regulate hematopoietic stem cell regeneration following radiation injury. Stem Cells 31(2):327-37. [PubMed: 23132593]  [MGI Ref ID J:194696]

Dowling MR; Josefsson EC; Henley KJ; Hodgkin PD; Kile BT. 2010. Platelet senescence is regulated by an internal timer, not damage inflicted by hits. Blood 116(10):1776-8. [PubMed: 20530288]  [MGI Ref ID J:164520]

Duckworth CA; Pritchard DM. 2009. Suppression of apoptosis, crypt hyperplasia, and altered differentiation in the colonic epithelia of bak-null mice. Gastroenterology 136(3):943-52. [PubMed: 19185578]  [MGI Ref ID J:146852]

Dunkle A; Dzhagalov I; He YW. 2010. Mcl-1 promotes survival of thymocytes by inhibition of Bak in a pathway separate from Bcl-2. Cell Death Differ 17(6):994-1002. [PubMed: 20057504]  [MGI Ref ID J:186374]

Fannjiang Y; Kim CH; Huganir RL; Zou S; Lindsten T; Thompson CB; Mito T; Traystman RJ; Larsen T; Griffin DE; Mandir AS; Dawson TM; Dike S; Sappington AL; Kerr DA; Jonas EA; Kaczmarek LK; Hardwick JM. 2003. BAK alters neuronal excitability and can switch from anti- to pro-death function during postnatal development. Dev Cell 4(4):575-85. [PubMed: 12689595]  [MGI Ref ID J:109013]

Fioramonti X; Marsollier N; Song Z; Fakira KA; Patel RM; Brown S; Duparc T; Pica-Mendez A; Sanders NM; Knauf C; Valet P; McCrimmon RJ; Beuve A; Magnan C; Routh VH. 2010. Ventromedial hypothalamic nitric oxide production is necessary for hypoglycemia detection and counterregulation. Diabetes 59(2):519-28. [PubMed: 19934009]  [MGI Ref ID J:164156]

Fontanini A; Foti C; Potu H; Crivellato E; Maestro R; Bernardi P; Demarchi F; Brancolini C. 2009. The Isopeptidase Inhibitor G5 Triggers a Caspase-independent Necrotic Death in Cells Resistant to Apoptosis: A COMPARATIVE STUDY WITH THE PROTEASOME INHIBITOR BORTEZOMIB. J Biol Chem 284(13):8369-81. [PubMed: 19139105]  [MGI Ref ID J:148618]

Garcia I; Crowther AJ; Gama V; Ryan Miller C; Deshmukh M; Gershon TR. 2013. Bax deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation. Oncogene 32(18):2304-14. [PubMed: 22710714]  [MGI Ref ID J:198027]

Garrison SP; Phillips DC; Jeffers JR; Chipuk JE; Parsons MJ; Rehg JE; Opferman JT; Green DR; Zambetti GP. 2012. Genetically defining the mechanism of Puma- and Bim-induced apoptosis. Cell Death Differ 19(4):642-9. [PubMed: 22015606]  [MGI Ref ID J:203075]

Gray DH; Kupresanin F; Berzins SP; Herold MJ; O'Reilly LA; Bouillet P; Strasser A. 2012. The BH3-Only Proteins Bim and Puma Cooperate to Impose Deletional Tolerance of Organ-Specific Antigens. Immunity 37(3):451-62. [PubMed: 22960223]  [MGI Ref ID J:187669]

Gruber JJ; Zatechka DS; Sabin LR; Yong J; Lum JJ; Kong M; Zong WX; Zhang Z; Lau CK; Rawlings J; Cherry S; Ihle JN; Dreyfuss G; Thompson CB. 2009. Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation. Cell 138(2):328-39. [PubMed: 19632182]  [MGI Ref ID J:152729]

Hahn P; Lindsten T; Lyubarsky A; Ying GS; Pugh EN Jr; Thompson CB; Dunaief JL. 2004. Deficiency of Bax and Bak protects photoreceptors from light damage in vivo. Cell Death Differ 11(11):1192-7. [PubMed: 15272317]  [MGI Ref ID J:134629]

Hahn P; Lindsten T; Tolentino M; Thompson CB; Bennett J; Dunaief JL. 2005. Persistent fetal ocular vasculature in mice deficient in bax and bak. Arch Ophthalmol 123(6):797-802. [PubMed: 15955981]  [MGI Ref ID J:115735]

Han C; Someya S. 2013. Mouse models of age-related mitochondrial neurosensory hearing loss. Mol Cell Neurosci 55:95-100. [PubMed: 22820179]  [MGI Ref ID J:203587]

Hetz C; Bernasconi P; Fisher J; Lee AH; Bassik MC; Antonsson B; Brandt GS; Iwakoshi NN; Schinzel A; Glimcher LH; Korsmeyer SJ. 2006. Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science 312(5773):572-6. [PubMed: 16645094]  [MGI Ref ID J:108337]

Hutcheson J; Perlman H. 2007. Loss of Bim results in abnormal accumulation of mature CD4-CD8-CD44-CD25- thymocytes. Immunobiology 212(8):629-36. [PubMed: 17869640]  [MGI Ref ID J:129934]

Hutcheson J; Scatizzi JC; Bickel E; Brown NJ; Bouillet P; Strasser A; Perlman H. 2005. Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis. J Exp Med 201(12):1949-60. [PubMed: 15967824]  [MGI Ref ID J:99285]

Imao T; Nagata S. 2013. Apaf-1- and Caspase-8-independent apoptosis. Cell Death Differ 20(2):343-52. [PubMed: 23197294]  [MGI Ref ID J:205616]

Jabbour AM; Heraud JE; Daunt CP; Kaufmann T; Sandow J; O'Reilly LA; Callus BA; Lopez A; Strasser A; Vaux DL; Ekert PG. 2009. Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim. Cell Death Differ 16(4):555-63. [PubMed: 19079139]  [MGI Ref ID J:158076]

Janssen K; Horn S; Niemann MT; Daniel PT; Schulze-Osthoff K; Fischer U. 2009. Inhibition of the ER Ca2+ pump forces multidrug-resistant cells deficient in Bak and Bax into necrosis. J Cell Sci 122(Pt 24):4481-91. [PubMed: 19920074]  [MGI Ref ID J:155568]

Jones RG; Bui T; White C; Madesh M; Krawczyk CM; Lindsten T; Hawkins BJ; Kubek S; Frauwirth KA; Wang YL; Conway SJ; Roderick HL; Bootman MD; Shen H; Foskett JK; Thompson CB. 2007. The Proapoptotic Factors Bax and Bak Regulate T Cell Proliferation through Control of Endoplasmic Reticulum Ca(2+) Homeostasis. Immunity 27(2):268-80. [PubMed: 17692540]  [MGI Ref ID J:124342]

Josefsson EC; Burnett DL; Lebois M; Debrincat MA; White MJ; Henley KJ; Lane RM; Moujalled D; Preston SP; O'Reilly LA; Pellegrini M; Metcalf D; Strasser A; Kile BT. 2014. Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways. Nat Commun 5:3455. [PubMed: 24632563]  [MGI Ref ID J:210320]

Josefsson EC; James C; Henley KJ; Debrincat MA; Rogers KL; Dowling MR; White MJ; Kruse EA; Lane RM; Ellis S; Nurden P; Mason KD; O'Reilly LA; Roberts AW; Metcalf D; Huang DC; Kile BT. 2011. Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets. J Exp Med 208(10):2017-31. [PubMed: 21911424]  [MGI Ref ID J:177288]

Karbowski M; Norris KL; Cleland MM; Jeong SY; Youle RJ. 2006. Role of Bax and Bak in mitochondrial morphogenesis. Nature 443(7112):658-62. [PubMed: 17035996]  [MGI Ref ID J:113296]

Karch J; Kwong JQ; Burr AR; Sargent MA; Elrod JW; Peixoto PM; Martinez-Caballero S; Osinska H; Cheng EH; Robbins J; Kinnally KW; Molkentin JD. 2013. Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice. Elife 2:e00772. [PubMed: 23991283]  [MGI Ref ID J:207795]

Katz SG; Fisher JK; Correll M; Bronson RT; Ligon KL; Walensky LD. 2013. Brain and testicular tumors in mice with progenitor cells lacking BAX and BAK. Oncogene 32(35):4078-85. [PubMed: 22986529]  [MGI Ref ID J:203245]

Kawai K; Itoh T; Itoh A; Horiuchi M; Wakayama K; Bannerman P; Garbern JY; Pleasure D; Lindsten T. 2009. Maintenance of the relative proportion of oligodendrocytes to axons even in the absence of BAX and BAK. Eur J Neurosci 30(11):2030-41. [PubMed: 20128842]  [MGI Ref ID J:157612]

Kirsch DG; Dinulescu DM; Miller JB; Grimm J; Santiago PM; Young NP; Nielsen GP; Quade BJ; Chaber CJ; Schultz CP; Takeuchi O; Bronson RT; Crowley D; Korsmeyer SJ; Yoon SS; Hornicek FJ; Weissleder R; Jacks T. 2007. A spatially and temporally restricted mouse model of soft tissue sarcoma. Nat Med 13(8):992-7. [PubMed: 17676052]  [MGI Ref ID J:125101]

Kirsch DG; Santiago PM; di Tomaso E; Sullivan JM; Hou WS; Dayton T; Jeffords LB; Sodha P; Mercer KL; Cohen R; Takeuchi O; Korsmeyer SJ; Bronson RT; Kim CF; Haigis KM; Jain RK; Jacks T. 2010. p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis. Science 327(5965):593-6. [PubMed: 20019247]  [MGI Ref ID J:156707]

Kodama T; Hikita H; Kawaguchi T; Shigekawa M; Shimizu S; Hayashi Y; Li W; Miyagi T; Hosui A; Tatsumi T; Kanto T; Hiramatsu N; Kiyomizu K; Tadokoro S; Tomiyama Y; Hayashi N; Takehara T. 2012. Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages. Cell Death Differ 19(11):1856-69. [PubMed: 22790873]  [MGI Ref ID J:205468]

Kodama T; Takehara T; Hikita H; Shimizu S; Shigekawa M; Li W; Miyagi T; Hosui A; Tatsumi T; Ishida H; Kanto T; Hiramatsu N; Yin XM; Hayashi N. 2011. BH3-only Activator Proteins Bid and Bim Are Dispensable for Bak/Bax-dependent Thrombocyte Apoptosis Induced by Bcl-xL Deficiency: MOLECULAR REQUISITES FOR THE MITOCHONDRIAL PATHWAY TO APOPTOSIS IN PLATELETS. J Biol Chem 286(16):13905-13. [PubMed: 21367852]  [MGI Ref ID J:171123]

Konishi A; Shimizu S; Hirota J; Takao T; Fan Y; Matsuoka Y; Zhang L; Yoneda Y; Fujii Y; Skoultchi AI; Tsujimoto Y. 2003. Involvement of histone H1.2 in apoptosis induced by DNA double-strand breaks. Cell 114(6):673-88. [PubMed: 14505568]  [MGI Ref ID J:107681]

Koss B; Morrison J; Perciavalle RM; Singh H; Rehg JE; Williams RT; Opferman JT. 2013. Requirement for antiapoptotic MCL-1 in the survival of BCR-ABL B-lineage acute lymphoblastic leukemia. Blood 122(9):1587-98. [PubMed: 23881917]  [MGI Ref ID J:202362]

Leu JI; George DL. 2007. Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondria. Genes Dev 21(23):3095-109. [PubMed: 18056423]  [MGI Ref ID J:127809]

Lindenboim L; Kringel S; Braun T; Borner C; Stein R. 2005. Bak but not Bax is essential for Bcl-xS-induced apoptosis. Cell Death Differ 12(7):713-23. [PubMed: 15861188]  [MGI Ref ID J:111864]

Lindsten T; Golden JA; Zong WX; Minarcik J; Harris MH; Thompson CB. 2003. The proapoptotic activities of Bax and Bak limit the size of the neural stem cell pool. J Neurosci 23(35):11112-9. [PubMed: 14657169]  [MGI Ref ID J:87971]

Lindsten T; Ross AJ; King A; Zong WX; Rathmell JC; Shiels HA; Ulrich E; Waymire KG; Mahar P; Frauwirth K; Chen Y; Wei M; Eng VM; Adelman DM; Simon MC; Ma A; Golden JA; Evan G; Korsmeyer SJ; MacGregor GR; Thompson CB. 2000. The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell 6(6):1389-99. [PubMed: 11163212]  [MGI Ref ID J:66872]

Lindsten T; Thompson CB. 2006. Cell death in the absence of Bax and Bak. Cell Death Differ 13(8):1272-6. [PubMed: 16676001]  [MGI Ref ID J:126409]

Lu MY; Liao F. 2011. Interferon-stimulated gene ISG12b2 is localized to the inner mitochondrial membrane and mediates virus-induced cell death. Cell Death Differ 18(6):925-36. [PubMed: 21151029]  [MGI Ref ID J:186970]

Luciani DS; White SA; Widenmaier SB; Saran VV; Taghizadeh F; Hu X; Allard MF; Johnson JD. 2013. Bcl-2 and Bcl-xL suppress glucose signaling in pancreatic beta-cells. Diabetes 62(1):170-82. [PubMed: 22933114]  [MGI Ref ID J:208489]

Lum JJ; Bauer DE; Kong M; Harris MH; Li C; Lindsten T; Thompson CB. 2005. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120(2):237-48. [PubMed: 15680329]  [MGI Ref ID J:97305]

Mason KD; Carpinelli MR; Fletcher JI; Collinge JE; Hilton AA; Ellis S; Kelly PN; Ekert PG; Metcalf D; Roberts AW; Huang DC; Kile BT. 2007. Programmed anuclear cell death delimits platelet life span. Cell 128(6):1173-86. [PubMed: 17382885]  [MGI Ref ID J:149205]

Mason KD; Lin A; Robb L; Josefsson EC; Henley KJ; Gray DH; Kile BT; Roberts AW; Strasser A; Huang DC; Waring P; O'Reilly LA. 2013. Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease. Proc Natl Acad Sci U S A 110(7):2599-604. [PubMed: 23349374]  [MGI Ref ID J:194331]

McKenzie MD; Carrington EM; Kaufmann T; Strasser A; Huang DC; Kay TW; Allison J; Thomas HE. 2008. Proapoptotic BH3-only protein Bid is essential for death receptor-induced apoptosis of pancreatic beta-cells. Diabetes 57(5):1284-92. [PubMed: 18252892]  [MGI Ref ID J:135326]

Merino D; Khaw SL; Glaser SP; Anderson DJ; Belmont LD; Wong C; Yue P; Robati M; Phipson B; Fairlie WD; Lee EF; Campbell KJ; Vandenberg CJ; Cory S; Roberts AW; Ludlam MJ; Huang DC; Bouillet P. 2012. Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells. Blood 119(24):5807-16. [PubMed: 22538851]  [MGI Ref ID J:188645]

Moubarak RS; Yuste VJ; Artus C; Bouharrour A; Greer PA; Menissier-de Murcia J; Susin SA. 2007. Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis. Mol Cell Biol 27(13):4844-62. [PubMed: 17470554]  [MGI Ref ID J:122803]

Nogueira CV; Lindsten T; Jamieson AM; Case CL; Shin S; Thompson CB; Roy CR. 2009. Rapid pathogen-induced apoptosis: a mechanism used by dendritic cells to limit intracellular replication of Legionella pneumophila. PLoS Pathog 5(6):e1000478. [PubMed: 19521510]  [MGI Ref ID J:211458]

Owens TW; Foster FM; Valentijn A; Gilmore AP; Streuli CH. 2010. Role for X-linked Inhibitor of apoptosis protein upstream of mitochondrial permeabilization. J Biol Chem 285(2):1081-8. [PubMed: 19875445]  [MGI Ref ID J:161686]

Pardo J; Urban C; Galvez EM; Ekert PG; Muller U; Kwon-Chung J; Lobigs M; Mullbacher A; Wallich R; Borner C; Simon MM. 2006. The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice. J Cell Biol 174(4):509-19. [PubMed: 16893972]  [MGI Ref ID J:112620]

Pierson W; Cauwe B; Policheni A; Schlenner SM; Franckaert D; Berges J; Humblet-Baron S; Schonefeldt S; Herold MJ; Hildeman D; Strasser A; Bouillet P; Lu LF; Matthys P; Freitas AA; Luther RJ; Weaver CT; Dooley J; Gray DH; Liston A. 2013. Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3(+) regulatory T cells. Nat Immunol 14(9):959-65. [PubMed: 23852275]  [MGI Ref ID J:208243]

Pietras EM; Lakshminarasimhan R; Techner JM; Fong S; Flach J; Binnewies M; Passegue E. 2014. Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons. J Exp Med 211(2):245-62. [PubMed: 24493802]  [MGI Ref ID J:208438]

Przemeck SM; Duckworth CA; Pritchard DM. 2007. Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2. Am J Physiol Gastrointest Liver Physiol 292(2):G620-7. [PubMed: 17068116]  [MGI Ref ID J:124814]

Raynor J; Sholl A; Plas DR; Bouillet P; Chougnet CA; Hildeman DA. 2013. IL-15 Fosters Age-Driven Regulatory T Cell Accrual in the Face of Declining IL-2 Levels. Front Immunol 4:161. [PubMed: 23805138]  [MGI Ref ID J:208318]

Ren D; Tu HC; Kim H; Wang GX; Bean GR; Takeuchi O; Jeffers JR; Zambetti GP; Hsieh JJ; Cheng EH. 2010. BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program. Science 330(6009):1390-3. [PubMed: 21127253]  [MGI Ref ID J:167307]

Reyes NA; Fisher JK; Austgen K; VandenBerg S; Huang EJ; Oakes SA. 2010. Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis. J Clin Invest 120(10):3673-9. [PubMed: 20890041]  [MGI Ref ID J:165330]

Ross AJ; Amy SP; Mahar PL; Lindsten T; Knudson CM; Thompson CB; Korsmeyer SJ; MacGregor GR. 2001. BCLW Mediates Survival of Postmitotic Sertoli Cells by Regulating BAX Activity. Dev Biol 239(2):295-308. [PubMed: 11784036]  [MGI Ref ID J:72582]

Ruiz-Vela A; Opferman JT; Cheng EH; Korsmeyer SJ. 2005. Proapoptotic BAX and BAK control multiple initiator caspases. EMBO Rep 6(4):379-85. [PubMed: 15776018]  [MGI Ref ID J:97306]

Schoenwaelder SM; Yuan Y; Josefsson EC; White MJ; Yao Y; Mason KD; O'Reilly LA; Henley KJ; Ono A; Hsiao S; Willcox A; Roberts AW; Huang DC; Salem HH; Kile BT; Jackson SP. 2009. Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function. Blood 114(3):663-6. [PubMed: 19387006]  [MGI Ref ID J:150769]

Schweers RL; Zhang J; Randall MS; Loyd MR; Li W; Dorsey FC; Kundu M; Opferman JT; Cleveland JL; Miller JL; Ney PA. 2007. NIX is required for programmed mitochondrial clearance during reticulocyte maturation. Proc Natl Acad Sci U S A 104(49):19500-5. [PubMed: 18048346]  [MGI Ref ID J:141545]

Someya S; Xu J; Kondo K; Ding D; Salvi RJ; Yamasoba T; Rabinovitch PS; Weindruch R; Leeuwenburgh C; Tanokura M; Prolla TA. 2009. Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis. Proc Natl Acad Sci U S A 106(46):19432-7. [PubMed: 19901338]  [MGI Ref ID J:154747]

Tormo D; Checinska A; Alonso-Curbelo D; Perez-Guijarro E; Canon E; Riveiro-Falkenbach E; Calvo TG; Larribere L; Megias D; Mulero F; Piris MA; Dash R; Barral PM; Rodriguez-Peralto JL; Ortiz-Romero P; Tuting T; Fisher PB; Soengas MS. 2009. Targeted activation of innate immunity for therapeutic induction of autophagy and apoptosis in melanoma cells. Cancer Cell 16(2):103-14. [PubMed: 19647221]  [MGI Ref ID J:151975]

Upton JP; Austgen K; Nishino M; Coakley KM; Hagen A; Han D; Papa FR; Oakes SA. 2008. Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress. Mol Cell Biol 28(12):3943-51. [PubMed: 18426910]  [MGI Ref ID J:137299]

Vince JE; Wong WW; Gentle I; Lawlor KE; Allam R; O'Reilly L; Mason K; Gross O; Ma S; Guarda G; Anderton H; Castillo R; Hacker G; Silke J; Tschopp J. 2012. Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation. Immunity 36(2):215-27. [PubMed: 22365665]  [MGI Ref ID J:181625]

Wang X; Eno CO; Altman BJ; Zhu Y; Zhao G; Olberding KE; Rathmell JC; Li C. 2011. ER stress modulates cellular metabolism. Biochem J 435(1):285-96. [PubMed: 21241252]  [MGI Ref ID J:170628]

Warr MR; Binnewies M; Flach J; Reynaud D; Garg T; Malhotra R; Debnath J; Passegue E. 2013. FOXO3A directs a protective autophagy program in haematopoietic stem cells. Nature 494(7437):323-7. [PubMed: 23389440]  [MGI Ref ID J:194535]

Weinlich R; Oberst A; Dillon CP; Janke LJ; Milasta S; Lukens JR; Rodriguez DA; Gurung P; Savage C; Kanneganti TD; Green DR. 2013. Protective roles for caspase-8 and cFLIP in adult homeostasis. Cell Rep 5(2):340-8. [PubMed: 24095739]  [MGI Ref ID J:203778]

Whelan RS; Konstantinidis K; Wei AC; Chen Y; Reyna DE; Jha S; Yang Y; Calvert JW; Lindsten T; Thompson CB; Crow MT; Gavathiotis E; Dorn GW 2nd; O'Rourke B; Kitsis RN. 2012. Bax regulates primary necrosis through mitochondrial dynamics. Proc Natl Acad Sci U S A 109(17):6566-71. [PubMed: 22493254]  [MGI Ref ID J:183839]

White MJ; Schoenwaelder SM; Josefsson EC; Jarman KE; Henley KJ; James C; Debrincat MA; Jackson SP; Huang DC; Kile BT. 2012. Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function. Blood 119(18):4283-90. [PubMed: 22294729]  [MGI Ref ID J:185011]

Wolpaw AJ; Shimada K; Skouta R; Welsch ME; Akavia UD; Pe'er D; Shaik F; Bulinski JC; Stockwell BR. 2011. Modulatory profiling identifies mechanisms of small molecule-induced cell death. Proc Natl Acad Sci U S A 108(39):E771-80. [PubMed: 21896738]  [MGI Ref ID J:176584]

Yee KS; Wilkinson S; James J; Ryan KM; Vousden KH. 2009. PUMA- and Bax-induced autophagy contributes to apoptosis. Cell Death Differ 16(8):1135-45. [PubMed: 19300452]  [MGI Ref ID J:164186]

Zhang Y; Iqbal S; O'Leary MF; Menzies KJ; Saleem A; Ding S; Hood DA. 2013. Altered mitochondrial morphology and defective protein import reveal novel roles for Bax and/or Bak in skeletal muscle. Am J Physiol Cell Physiol 305(5):C502-11. [PubMed: 23784543]  [MGI Ref ID J:210120]

Zhu Y; Liu X; Hildeman D; Peyerl FW; White J; Kushnir E; Kappler J; Marrack P. 2006. Bax does not have to adopt its final form to drive T cell death. J Exp Med 203(5):1147-52. [PubMed: 16651384]  [MGI Ref ID J:124139]

Zong WX; Ditsworth D; Bauer DE; Wang ZQ; Thompson CB. 2004. Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes Dev 18(11):1272-82. [PubMed: 15145826]  [MGI Ref ID J:118568]

Baxtm2Sjk related

Biswas S; Shi Q; Matise L; Cleveland S; Dave U; Zinkel S. 2010. A role for proapoptotic Bax and Bak in T-cell differentiation and transformation. Blood 116(24):5237-46. [PubMed: 20813900]  [MGI Ref ID J:167419]

Cammas L; Wolfe J; Choi SY; Dedhar S; Beggs HE. 2012. Integrin-linked kinase deletion in the developing lens leads to capsule rupture, impaired fiber migration and non-apoptotic epithelial cell death. Invest Ophthalmol Vis Sci 53(6):3067-81. [PubMed: 22491404]  [MGI Ref ID J:196836]

Chen M; Felix K; Wang J. 2011. Immune regulation through mitochondrion-dependent dendritic cell death induced by T regulatory cells. J Immunol 187(11):5684-92. [PubMed: 22031758]  [MGI Ref ID J:179762]

Chen SK; Chew KS; McNeill DS; Keeley PW; Ecker JL; Mao BQ; Pahlberg J; Kim B; Lee SC; Fox MA; Guido W; Wong KY; Sampath AP; Reese BE; Kuruvilla R; Hattar S. 2013. Apoptosis regulates ipRGC spacing necessary for rods and cones to drive circadian photoentrainment. Neuron 77(3):503-15. [PubMed: 23395376]  [MGI Ref ID J:197847]

Crowther AJ; Gama V; Bevilacqua A; Chang SX; Yuan H; Deshmukh M; Gershon TR. 2013. Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma. J Neurosci 33(46):18098-108. [PubMed: 24227720]  [MGI Ref ID J:204171]

Di Paolo NC; Doronin K; Baldwin LK; Papayannopoulou T; Shayakhmetov DM. 2013. The Transcription Factor IRF3 Triggers "Defensive Suicide" Necrosis in Response to Viral and Bacterial Pathogens. Cell Rep 3(6):1840-6. [PubMed: 23770239]  [MGI Ref ID J:199310]

Doan PL; Himburg HA; Helms K; Russell JL; Fixsen E; Quarmyne M; Harris JR; Deoliviera D; Sullivan JM; Chao NJ; Kirsch DG; Chute JP. 2013. Epidermal growth factor regulates hematopoietic regeneration after radiation injury. Nat Med 19(3):295-304. [PubMed: 23377280]  [MGI Ref ID J:196315]

Doan PL; Russell JL; Himburg HA; Helms K; Harris JR; Lucas J; Holshausen KC; Meadows SK; Daher P; Jeffords LB; Chao NJ; Kirsch DG; Chute JP. 2013. Tie2(+) bone marrow endothelial cells regulate hematopoietic stem cell regeneration following radiation injury. Stem Cells 31(2):327-37. [PubMed: 23132593]  [MGI Ref ID J:194696]

Hetz C; Bernasconi P; Fisher J; Lee AH; Bassik MC; Antonsson B; Brandt GS; Iwakoshi NN; Schinzel A; Glimcher LH; Korsmeyer SJ. 2006. Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science 312(5773):572-6. [PubMed: 16645094]  [MGI Ref ID J:108337]

Imao T; Nagata S. 2013. Apaf-1- and Caspase-8-independent apoptosis. Cell Death Differ 20(2):343-52. [PubMed: 23197294]  [MGI Ref ID J:205616]

Josefsson EC; Burnett DL; Lebois M; Debrincat MA; White MJ; Henley KJ; Lane RM; Moujalled D; Preston SP; O'Reilly LA; Pellegrini M; Metcalf D; Strasser A; Kile BT. 2014. Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways. Nat Commun 5:3455. [PubMed: 24632563]  [MGI Ref ID J:210320]

Josefsson EC; James C; Henley KJ; Debrincat MA; Rogers KL; Dowling MR; White MJ; Kruse EA; Lane RM; Ellis S; Nurden P; Mason KD; O'Reilly LA; Roberts AW; Metcalf D; Huang DC; Kile BT. 2011. Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets. J Exp Med 208(10):2017-31. [PubMed: 21911424]  [MGI Ref ID J:177288]

Karch J; Kwong JQ; Burr AR; Sargent MA; Elrod JW; Peixoto PM; Martinez-Caballero S; Osinska H; Cheng EH; Robbins J; Kinnally KW; Molkentin JD. 2013. Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice. Elife 2:e00772. [PubMed: 23991283]  [MGI Ref ID J:207795]

Katz SG; Fisher JK; Correll M; Bronson RT; Ligon KL; Walensky LD. 2013. Brain and testicular tumors in mice with progenitor cells lacking BAX and BAK. Oncogene 32(35):4078-85. [PubMed: 22986529]  [MGI Ref ID J:203245]

Kirsch DG; Dinulescu DM; Miller JB; Grimm J; Santiago PM; Young NP; Nielsen GP; Quade BJ; Chaber CJ; Schultz CP; Takeuchi O; Bronson RT; Crowley D; Korsmeyer SJ; Yoon SS; Hornicek FJ; Weissleder R; Jacks T. 2007. A spatially and temporally restricted mouse model of soft tissue sarcoma. Nat Med 13(8):992-7. [PubMed: 17676052]  [MGI Ref ID J:125101]

Kirsch DG; Santiago PM; di Tomaso E; Sullivan JM; Hou WS; Dayton T; Jeffords LB; Sodha P; Mercer KL; Cohen R; Takeuchi O; Korsmeyer SJ; Bronson RT; Kim CF; Haigis KM; Jain RK; Jacks T. 2010. p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis. Science 327(5965):593-6. [PubMed: 20019247]  [MGI Ref ID J:156707]

Kodama T; Hikita H; Kawaguchi T; Shigekawa M; Shimizu S; Hayashi Y; Li W; Miyagi T; Hosui A; Tatsumi T; Kanto T; Hiramatsu N; Kiyomizu K; Tadokoro S; Tomiyama Y; Hayashi N; Takehara T. 2012. Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages. Cell Death Differ 19(11):1856-69. [PubMed: 22790873]  [MGI Ref ID J:205468]

Kodama T; Takehara T; Hikita H; Shimizu S; Shigekawa M; Li W; Miyagi T; Hosui A; Tatsumi T; Ishida H; Kanto T; Hiramatsu N; Yin XM; Hayashi N. 2011. BH3-only Activator Proteins Bid and Bim Are Dispensable for Bak/Bax-dependent Thrombocyte Apoptosis Induced by Bcl-xL Deficiency: MOLECULAR REQUISITES FOR THE MITOCHONDRIAL PATHWAY TO APOPTOSIS IN PLATELETS. J Biol Chem 286(16):13905-13. [PubMed: 21367852]  [MGI Ref ID J:171123]

Koss B; Morrison J; Perciavalle RM; Singh H; Rehg JE; Williams RT; Opferman JT. 2013. Requirement for antiapoptotic MCL-1 in the survival of BCR-ABL B-lineage acute lymphoblastic leukemia. Blood 122(9):1587-98. [PubMed: 23881917]  [MGI Ref ID J:202362]

Kurtulus S; Tripathi P; Moreno-Fernandez ME; Sholl A; Katz JD; Grimes HL; Hildeman DA. 2011. Bcl-2 allows effector and memory CD8+ T cells to tolerate higher expression of Bim. J Immunol 186(10):5729-37. [PubMed: 21451108]  [MGI Ref ID J:173111]

Luciani DS; White SA; Widenmaier SB; Saran VV; Taghizadeh F; Hu X; Allard MF; Johnson JD. 2013. Bcl-2 and Bcl-xL suppress glucose signaling in pancreatic beta-cells. Diabetes 62(1):170-82. [PubMed: 22933114]  [MGI Ref ID J:208489]

Pierson W; Cauwe B; Policheni A; Schlenner SM; Franckaert D; Berges J; Humblet-Baron S; Schonefeldt S; Herold MJ; Hildeman D; Strasser A; Bouillet P; Lu LF; Matthys P; Freitas AA; Luther RJ; Weaver CT; Dooley J; Gray DH; Liston A. 2013. Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3(+) regulatory T cells. Nat Immunol 14(9):959-65. [PubMed: 23852275]  [MGI Ref ID J:208243]

Pietras EM; Lakshminarasimhan R; Techner JM; Fong S; Flach J; Binnewies M; Passegue E. 2014. Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons. J Exp Med 211(2):245-62. [PubMed: 24493802]  [MGI Ref ID J:208438]

Raynor J; Sholl A; Plas DR; Bouillet P; Chougnet CA; Hildeman DA. 2013. IL-15 Fosters Age-Driven Regulatory T Cell Accrual in the Face of Declining IL-2 Levels. Front Immunol 4:161. [PubMed: 23805138]  [MGI Ref ID J:208318]

Ren D; Tu HC; Kim H; Wang GX; Bean GR; Takeuchi O; Jeffers JR; Zambetti GP; Hsieh JJ; Cheng EH. 2010. BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program. Science 330(6009):1390-3. [PubMed: 21127253]  [MGI Ref ID J:167307]

Reyes NA; Fisher JK; Austgen K; VandenBerg S; Huang EJ; Oakes SA. 2010. Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis. J Clin Invest 120(10):3673-9. [PubMed: 20890041]  [MGI Ref ID J:165330]

Sahay A; Scobie KN; Hill AS; O'Carroll CM; Kheirbek MA; Burghardt NS; Fenton AA; Dranovsky A; Hen R. 2011. Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation. Nature 472(7344):466-70. [PubMed: 21460835]  [MGI Ref ID J:171377]

Schweers RL; Zhang J; Randall MS; Loyd MR; Li W; Dorsey FC; Kundu M; Opferman JT; Cleveland JL; Miller JL; Ney PA. 2007. NIX is required for programmed mitochondrial clearance during reticulocyte maturation. Proc Natl Acad Sci U S A 104(49):19500-5. [PubMed: 18048346]  [MGI Ref ID J:141545]

Upton JP; Austgen K; Nishino M; Coakley KM; Hagen A; Han D; Papa FR; Oakes SA. 2008. Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress. Mol Cell Biol 28(12):3943-51. [PubMed: 18426910]  [MGI Ref ID J:137299]

Wang X; Bathina M; Lynch J; Koss B; Calabrese C; Frase S; Schuetz JD; Rehg JE; Opferman JT. 2013. Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction. Genes Dev 27(12):1351-64. [PubMed: 23788622]  [MGI Ref ID J:199155]

Warr MR; Binnewies M; Flach J; Reynaud D; Garg T; Malhotra R; Debnath J; Passegue E. 2013. FOXO3A directs a protective autophagy program in haematopoietic stem cells. Nature 494(7437):323-7. [PubMed: 23389440]  [MGI Ref ID J:194535]

Whelan RS; Konstantinidis K; Wei AC; Chen Y; Reyna DE; Jha S; Yang Y; Calvert JW; Lindsten T; Thompson CB; Crow MT; Gavathiotis E; Dorn GW 2nd; O'Rourke B; Kitsis RN. 2012. Bax regulates primary necrosis through mitochondrial dynamics. Proc Natl Acad Sci U S A 109(17):6566-71. [PubMed: 22493254]  [MGI Ref ID J:183839]

Zhang Y; Iqbal S; O'Leary MF; Menzies KJ; Saleem A; Ding S; Hood DA. 2013. Altered mitochondrial morphology and defective protein import reveal novel roles for Bax and/or Bak in skeletal muscle. Am J Physiol Cell Physiol 305(5):C502-11. [PubMed: 23784543]  [MGI Ref ID J:210120]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, double homozygous mice are bred together.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2525.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $1650.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3283.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Frozen Products

Price (US dollars $)
Frozen Embryo $2145.00

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   101043 B6129SF1/J (approximate)
   101045 B6129SF2/J (approximate)
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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