Strain Name:

B6.Cg-Lgals1tm1Rob/J

Stock Number:

006337

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Availability:

Cryopreserved - Ready for recovery

Use Restrictions Apply, see Terms of Use

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
GenerationN5+N1F1pN1
Generation Definitions
 
Donating Investigator Richard D. Cummings,   University of Oklahoma

Description
Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical abnormalities. No gene product (mRNA or protein) is detected by in situ hybridization of dorsal root ganglia and facial motorneuron nucleus and Western blot analysis of adult muscle tissue. Neonate mice homozygous for the mutation have abnormal axon targeting to the caudal region of the olfactory bulb. Mutant mice have fewer neural progenitor cells in the subventricular zone of the forebrain, although the number of apoptotic cells are not affected. Homozygotes exhibit hypoalgesia with a diminished nocifensive withdraw response to thermal testing. Immunohistological analysis of dorsal root ganglia from homozygotes reveals abnormal proportions of axon subpopulations and a larger number of myelinated axons. Mutant mice have a longer recovery of motorneuron function after experimental nerve injury. This mutant mouse strain represents a model that may be useful in studies of pain reception, motorneuron regeneration, axonal growth and guidance and development of the nervous system.

This strain was transferred from the collection of the Consortium for Functional Glycomics.

It has been the experience of The Jackson Laboratory that these mice experience a transient period of hairloss between the ages of 2-6 weeks, with full hair growth returning by six weeks of age. Analysis of skin sections reveals a pathology similar to what is seen in C57BL/6 alopecia and movement of these alleles onto the C57BL/6J background may have exacerbated this phenotype.

Development
A targeting vector containing neomycin resistance and herpes simplex virus thymidine kinase genes was used to disrupt 1.0kb of sequence that includes exon 2. The construct was electroporated into 129S6/SvEvTac derived CCE embryonic stem (ES) cells. Correctly targeted ES cells were injected into outbred MF-1 blastocysts. The resulting chimeric male animals were crossed to outbred MF-1 female mice. Heterozygotes were crossed to generate homozygotes. The mice were then bred to mice homozygous for a targeted mutation of Lgals3. The double mutant strain was then backcrossed to C57BL/6 for 5 generations. Upon arrival at The Jackson Laboratory, the second allele was removed by selective breeding. These mice carry only the Lgals1tm1Rob allele.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Lgals1tm1Rob allele
006354   B6.Cg-Lgals3tm1Poi Lgals1tm1Rob/J
View Strains carrying   Lgals1tm1Rob     (1 strain)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Lgals1tm1Rob/Lgals1tm1Rob

        involves: 129S/SvEv * MF1
  • nervous system phenotype
  • abnormal olfactory nerve morphology
    • although the olfactory nerve itself was normal, projections from it to the dorsocaudal surface of the olfactory bulb were severly reduced and axons never terminated in glomeruli   (MGI Ref ID J:36694)
    • mice were otherwise normal   (MGI Ref ID J:36694)
  • normal phenotype
  • no abnormal phenotype detected
    • mice are normal   (MGI Ref ID J:16245)

Lgals1tm1Rob/Lgals1tm1Rob

        involves: 129S/SvEv
  • nervous system phenotype
  • abnormal dorsal root ganglion morphology
    • mice exhibit fewer IB4-binding neurons (non-peptidergic nociceptor neurons), more NF200-exressing neurons (large-diameter mechanoreceptor neurons) and more myelinated sensory axons in the dorsal root ganglia than in wild-type mice   (MGI Ref ID J:101850)
    • the mean diameter of neurons in the dorsal root ganglia is reduced compared to in wild-type mice   (MGI Ref ID J:101850)
    • however, the total number of neurons in the dorsal root ganglia is normal   (MGI Ref ID J:101850)
  • abnormal neuromuscular synapse morphology
    • mice exhibit a delay in eliminating nerve endings after axotomy compared to in wild-type mice   (MGI Ref ID J:122104)
  • abnormal postnatal subventricular zone morphology
    • mice exhibit fewer proliferating cells and slowly dividing cells in the adult subventricular zone (SVZ) compared to in wild-type mice   (MGI Ref ID J:109590)
    • fewer progenitor cells are found in the adult SVZ compared to in wild-type mice   (MGI Ref ID J:109590)
    • however, the number of apoptotic cells in the SVZ is normal   (MGI Ref ID J:109590)
  • abnormal sensory neuron morphology
    • mice exhibit more myelinated sensory axons in the dorsal root ganglia than in wild-type mice   (MGI Ref ID J:101850)
    • abnormal mechanoreceptor morphology
      • mice exhibit fewer IB4-binding neurons (non-peptidergic nociceptor neurons) in the dorsal root ganglia than in wild-type mice   (MGI Ref ID J:101850)
      • IB4-binding axons extend deeper into the dorsal horn of the spinal cord than in wild-type mice   (MGI Ref ID J:101850)
    • abnormal nociceptor morphology
      • mice exhibit more myelinated sensory axons in the dorsal root ganglia than in wild-type mice   (MGI Ref ID J:101850)
    • abnormal olfactory sensory neuron morphology
      • olfactory axons exhibit abnormal projections in the dorsocaudal olfactory bulb and, unlike in wild-type mice most axons do not terminate in discrete glomeruli   (MGI Ref ID J:36694)
  • immune system phenotype
  • increased interferon-gamma secretion
    • stimulated CD4+ T cells secrete more IFN-gamma than wild-type mice   (MGI Ref ID J:123416)
  • increased interleukin-2 secretion
    • stimulated CD4+ T cells secrete more IL-2 than wild-type mice   (MGI Ref ID J:123416)
  • increased susceptibility to experimental autoimmune encephalomyelitis
    • when treated to induce experimental autoimmune encephalomyelitis, mice exhibit a more severe disease, vigorous splenocyte proliferation, IL-17 and IFN-gamma production and a greater accumulation of MOG35-55-specific TH1 and TH-17 cells compared to in similarly treated wild-type mice   (MGI Ref ID J:123416)
  • muscle phenotype
  • delayed muscle development
    • mice exhibit a delay in muscle development beginning at day 1 through day 7   (MGI Ref ID J:119480)
  • behavior/neurological phenotype
  • increased thermal nociceptive threshold   (MGI Ref ID J:101850)
  • integument phenotype
  • increased thermal nociceptive threshold   (MGI Ref ID J:101850)
  • craniofacial phenotype
  • abnormal olfactory sensory neuron morphology
    • olfactory axons exhibit abnormal projections in the dorsocaudal olfactory bulb and, unlike in wild-type mice most axons do not terminate in discrete glomeruli   (MGI Ref ID J:36694)
  • respiratory system phenotype
  • abnormal olfactory sensory neuron morphology
    • olfactory axons exhibit abnormal projections in the dorsocaudal olfactory bulb and, unlike in wild-type mice most axons do not terminate in discrete glomeruli   (MGI Ref ID J:36694)
  • taste/olfaction phenotype
  • abnormal olfactory sensory neuron morphology
    • olfactory axons exhibit abnormal projections in the dorsocaudal olfactory bulb and, unlike in wild-type mice most axons do not terminate in discrete glomeruli   (MGI Ref ID J:36694)
  • growth/size/body phenotype
  • abnormal olfactory sensory neuron morphology
    • olfactory axons exhibit abnormal projections in the dorsocaudal olfactory bulb and, unlike in wild-type mice most axons do not terminate in discrete glomeruli   (MGI Ref ID J:36694)

Lgals1tm1Rob/Lgals1tm1Rob

        involves: 129S/SvEv * 129S1/SvImJ * DBA/2J
  • immune system phenotype
  • abnormal cytokine secretion
    • following treatment with dydrogesterone, uterine support cells exhibit an increase in TH1 to TH2 cytokine ratio compared to wild-type mice   (MGI Ref ID J:130208)
  • reproductive system phenotype
  • *normal* reproductive system phenotype
    • mice exhibit more fetal loss than in wild-type mice without altered number of implantation sites or litter size   (MGI Ref ID J:130208)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Developmental Biology Research
Neurodevelopmental Defects

Neurobiology Research
Neurodevelopmental Defects

Sensorineural Research
Nociception

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Lgals1tm1Rob
Allele Name targeted mutation 1, Elizabeth J Robertson
Allele Type Targeted (Null/Knockout)
Common Name(s) Lgals1-; gal-1-; gal1-;
Mutation Made By Richard Cummings,   University of Oklahoma
Strain of Origin129S/SvEv-Gpi1
ES Cell Line NameCCE/EK.CCE
ES Cell Line Strain129S/SvEv-Gpi1
Gene Symbol and Name Lgals1, lectin, galactose binding, soluble 1
Chromosome 15
Gene Common Name(s) AA410090; GAL1; GBP; Gal-1; Galbp; L14; Lect14; beta galactoside binding protein; expressed sequence AA410090; galectin-1; lactose binding soluble lectin, 14 kDa;
Molecular Note Exon 2, encoding the carbohydrate-binding domain, was replaced with a neomycin selection cassette. Western blot analysis and immunostaining of sections showed an absence of encoded protein in muscle tissue obtained from adult homozygous mutant mice. [MGI Ref ID J:16245]

Genotyping

Genotyping Information

Genotyping Protocols

Lgals1tm1Rob, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Poirier F; Robertson EJ. 1993. Normal development of mice carrying a null mutation in the gene encoding the L14 S-type lectin. Development 119(4):1229-36. [PubMed: 8306885]  [MGI Ref ID J:16245]

Additional References

Lgals1tm1Rob related

Anginot A; Espeli M; Chasson L; Mancini SJ; Schiff C. 2013. Galectin 1 modulates plasma cell homeostasis and regulates the humoral immune response. J Immunol 190(11):5526-33. [PubMed: 23616571]  [MGI Ref ID J:204783]

Banh A; Zhang J; Cao H; Bouley DM; Kwok S; Kong C; Giaccia AJ; Koong AC; Le QT. 2011. Tumor Galectin-1 Mediates Tumor Growth and Metastasis through Regulation of T-Cell Apoptosis. Cancer Res 71(13):4423-31. [PubMed: 21546572]  [MGI Ref ID J:173630]

Barrionuevo P; Beigier-Bompadre M; Ilarregui JM; Toscano MA; Bianco GA; Isturiz MA; Rabinovich GA. 2007. A novel function for galectin-1 at the crossroad of innate and adaptive immunity: galectin-1 regulates monocyte/macrophage physiology through a nonapoptotic ERK-dependent pathway. J Immunol 178(1):436-45. [PubMed: 17182582]  [MGI Ref ID J:141926]

Bermejo DA; Jackson SW; Gorosito-Serran M; Acosta-Rodriguez EV; Amezcua-Vesely MC; Sather BD; Singh AK; Khim S; Mucci J; Liggitt D; Campetella O; Oukka M; Gruppi A; Rawlings DJ. 2013. Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORgammat and Ahr that leads to IL-17 production by activated B cells. Nat Immunol 14(5):514-22. [PubMed: 23563688]  [MGI Ref ID J:196434]

Bischoff V; Deogracias R; Poirier F; Barde YA. 2012. Seizure-induced neuronal death is suppressed in the absence of the endogenous lectin Galectin-1. J Neurosci 32(44):15590-600. [PubMed: 23115194]  [MGI Ref ID J:192288]

Blois SM; Ilarregui JM; Tometten M; Garcia M; Orsal AS; Cordo-Russo R; Toscano MA; Bianco GA; Kobelt P; Handjiski B; Tirado I; Markert UR; Klapp BF; Poirier F; Szekeres-Bartho J; Rabinovich GA; Arck PC. 2007. A pivotal role for galectin-1 in fetomaternal tolerance. Nat Med 13(12):1450-7. [PubMed: 18026113]  [MGI Ref ID J:130208]

Cao Z; Said N; Amin S; Wu HK; Bruce A; Garate M; Hsu DK; Kuwabara I; Liu FT; Panjwani N. 2002. Galectins-3 and -7, but not galectin-1, play a role in re-epithelialization of wounds. J Biol Chem 277(44):42299-305. [PubMed: 12194966]  [MGI Ref ID J:79889]

Case D; Irwin D; Ivester C; Harral J; Morris K; Imamura M; Roedersheimer M; Patterson A; Carr M; Hagen M; Saavedra M; Crossno J Jr; Young KA; Dempsey EC; Poirier F; West J; Majka S. 2007. Mice deficient in galectin-1 exhibit attenuated physiological responses to chronic hypoxia-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 292(1):L154-64. [PubMed: 16951131]  [MGI Ref ID J:141598]

Colnot C; Fowlis D; Ripoche MA; Bouchaert I; Poirier F. 1998. Embryonic implantation in galectin 1/galectin 3 double mutant mice. Dev Dyn 211(4):306-13. [PubMed: 9566950]  [MGI Ref ID J:47227]

Colnot C; Ripoche MA; Scaerou F; Foulis D; Poirier F. 1996. Galectins in mouse embryogenesis. Biochem Soc Trans 24(1):141-6. [PubMed: 8674632]  [MGI Ref ID J:31899]

Cooper D; Norling LV; Perretti M. 2008. Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow. J Leukoc Biol 83(6):1459-66. [PubMed: 18372340]  [MGI Ref ID J:136833]

Croci DO; Salatino M; Rubinstein N; Cerliani JP; Cavallin LE; Leung HJ; Ouyang J; Ilarregui JM; Toscano MA; Domaica CI; Croci MC; Shipp MA; Mesri EA; Albini A; Rabinovich GA. 2012. Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma. J Exp Med 209(11):1985-2000. [PubMed: 23027923]  [MGI Ref ID J:190944]

Duchez S; Pascal V; Cogne N; Jayat-Vignoles C; Julien R; Cogne M. 2011. Glycotranscriptome study reveals an enzymatic switch modulating glycosaminoglycan synthesis during B-cell development and activation. Eur J Immunol 41(12):3632-44. [PubMed: 22076801]  [MGI Ref ID J:179675]

Espeli M; Mancini SJ; Breton C; Poirier F; Schiff C. 2009. Impaired B-cell development at the pre-BII-cell stage in galectin-1-deficient mice due to inefficient pre-BII/stromal cell interactions. Blood 113(23):5878-86. [PubMed: 19329777]  [MGI Ref ID J:149365]

Garin MI; Chu CC; Golshayan D; Cernuda-Morollon E; Wait R; Lechler RI. 2007. Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells. Blood 109(5):2058-65. [PubMed: 17110462]  [MGI Ref ID J:145355]

Gaudet AD; Leung M; Poirier F; Kadoya T; Horie H; Ramer MS. 2009. A role for galectin-1 in the immune response to peripheral nerve injury. Exp Neurol 220(2):320-7. [PubMed: 19766118]  [MGI Ref ID J:154869]

Georgiadis V; Stewart HJ; Pollard HJ; Tavsanoglu Y; Prasad R; Horwood J; Deltour L; Goldring K; Poirier F; Lawrence-Watt DJ. 2007. Lack of galectin-1 results in defects in myoblast fusion and muscle regeneration. Dev Dyn 236(4):1014-1024. [PubMed: 17366633]  [MGI Ref ID J:119480]

Ilarregui JM; Croci DO; Bianco GA; Toscano MA; Salatino M; Vermeulen ME; Geffner JR; Rabinovich GA. 2009. Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10. Nat Immunol 10(9):981-91. [PubMed: 19668220]  [MGI Ref ID J:151758]

Iqbal AJ; Cooper D; Vugler A; Gittens BR; Moore A; Perretti M. 2013. Endogenous galectin-1 exerts tonic inhibition on experimental arthritis. J Immunol 191(1):171-7. [PubMed: 23720814]  [MGI Ref ID J:205368]

Iqbal AJ; Sampaio AL; Maione F; Greco KV; Niki T; Hirashima M; Perretti M; Cooper D. 2011. Endogenous galectin-1 and acute inflammation emerging notion of a galectin-9 pro-resolving effect. Am J Pathol 178(3):1201-9. [PubMed: 21356371]  [MGI Ref ID J:169688]

Jouault T; El Abed-El Behi M; Martinez-Esparza M; Breuilh L; Trinel PA; Chamaillard M; Trottein F; Poulain D. 2006. Specific recognition of Candida albicans by macrophages requires galectin-3 to discriminate Saccharomyces cerevisiae and needs association with TLR2 for signaling. J Immunol 177(7):4679-87. [PubMed: 16982907]  [MGI Ref ID J:139314]

Liu SD; Tomassian T; Bruhn KW; Miller JF; Poirier F; Miceli MC. 2009. Galectin-1 tunes TCR binding and signal transduction to regulate CD8 burst size. J Immunol 182(9):5283-95. [PubMed: 19380775]  [MGI Ref ID J:147951]

Liu SD; Whiting CC; Tomassian T; Pang M; Bissel SJ; Baum LG; Mossine VV; Poirier F; Huflejt ME; Miceli MC. 2008. Endogenous galectin-1 enforces class I-restricted TCR functional fate decisions in thymocytes. Blood 112(1):120-30. [PubMed: 18323414]  [MGI Ref ID J:137307]

McGraw J; Gaudet AD; Oschipok LW; Steeves JD; Poirier F; Tetzlaff W; Ramer MS. 2005. Altered primary afferent anatomy and reduced thermal sensitivity in mice lacking galectin-1. Pain 114(1-2):7-18. [PubMed: 15733626]  [MGI Ref ID J:101850]

McGraw J; McPhail LT; Oschipok LW; Horie H; Poirier F; Steeves JD; Ramer MS; Tetzlaff W. 2004. Galectin-1 in regenerating motoneurons. Eur J Neurosci 20(11):2872-80. [PubMed: 15579141]  [MGI Ref ID J:101280]

Moore GT; Brown SJ; Winterhalter AC; Lust M; Salvaris EJ; Selan C; Nandurkar HH; Desmond PV; Cowan PJ; d'Apice AJ. 2008. Glycosylation changes in hFUT1 transgenic mice increase TCR signaling and apoptosis resulting in thymocyte maturation arrest. Mol Immunol 45(8):2401-10. [PubMed: 18155296]  [MGI Ref ID J:138374]

Moreau A; Noble A; Ratnasothy K; Chai JG; Deltour L; Cuturi MC; Simpson E; Lechler R; Lombardi G. 2012. Absence of Galectin-1 accelerates CD8+ T cell-mediated graft rejection. Eur J Immunol 42(11):2881-8. [PubMed: 22865279]  [MGI Ref ID J:188781]

Motran CC; Molinder KM; Liu SD; Poirier F; Miceli MC. 2008. Galectin-1 functions as a Th2 cytokine that selectively induces Th1 apoptosis and promotes Th2 function. Eur J Immunol 38(11):3015-27. [PubMed: 18991278]  [MGI Ref ID J:141406]

Mourcin F; Breton C; Tellier J; Narang P; Chasson L; Jorquera A; Coles M; Schiff C; Mancini SJ. 2011. Galectin-1-expressing stromal cells constitute a specific niche for pre-BII cell development in mouse bone marrow. Blood 117(24):6552-61. [PubMed: 21511956]  [MGI Ref ID J:174829]

Plachta N; Annaheim C; Bissiere S; Lin S; Ruegg M; Hoving S; Muller D; Poirier F; Bibel M; Barde YA. 2007. Identification of a lectin causing the degeneration of neuronal processes using engineered embryonic stem cells. Nat Neurosci 10(6):712-9. [PubMed: 17486104]  [MGI Ref ID J:122104]

Puche AC; Poirier F; Hair M; Bartlett PF; Key B. 1996. Role of galectin-1 in the developing mouse olfactory system. Dev Biol 179(1):274-87. [PubMed: 8873770]  [MGI Ref ID J:36694]

Rajasagi NK; Suryawanshi A; Sehrawat S; Reddy PB; Mulik S; Hirashima M; Rouse BT. 2012. Galectin-1 reduces the severity of herpes simplex virus-induced ocular immunopathological lesions. J Immunol 188(9):4631-43. [PubMed: 22467659]  [MGI Ref ID J:188446]

Romaniuk MA; Croci DO; Lapponi MJ; Tribulatti MV; Negrotto S; Poirier F; Campetella O; Rabinovich GA; Schattner M. 2012. Binding of galectin-1 to alphaIIbbeta(3) integrin triggers "outside-in" signals, stimulates platelet activation, and controls primary hemostasis. FASEB J 26(7):2788-98. [PubMed: 22456341]  [MGI Ref ID J:187476]

Saint-Lu N; Oortwijn BD; Pegon JN; Odouard S; Christophe OD; de Groot PG; Denis CV; Lenting PJ. 2012. Identification of galectin-1 and galectin-3 as novel partners for von Willebrand factor. Arterioscler Thromb Vasc Biol 32(4):894-901. [PubMed: 22267483]  [MGI Ref ID J:195956]

Sakaguchi M; Shingo T; Shimazaki T; Okano HJ; Shiwa M; Ishibashi S; Oguro H; Ninomiya M; Kadoya T; Horie H; Shibuya A; Mizusawa H; Poirier F; Nakauchi H; Sawamoto K; Okano H. 2006. A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells. Proc Natl Acad Sci U S A 103(18):7112-7. [PubMed: 16636291]  [MGI Ref ID J:109590]

Seropian IM; Cerliani JP; Toldo S; Van Tassell BW; Ilarregui JM; Gonzalez GE; Matoso M; Salloum FN; Melchior R; Gelpi RJ; Stupirski JC; Benatar A; Gomez KA; Morales C; Abbate A; Rabinovich GA. 2013. Galectin-1 controls cardiac inflammation and ventricular remodeling during acute myocardial infarction. Am J Pathol 182(1):29-40. [PubMed: 23142379]  [MGI Ref ID J:192233]

Shoji H; Deltour L; Nakamura T; Tajbakhsh S; Poirier F. 2009. Expression pattern and role of Galectin1 during early mouse myogenesis. Dev Growth Differ 51(7):607-15. [PubMed: 19712265]  [MGI Ref ID J:153078]

Starossom SC; Mascanfroni ID; Imitola J; Cao L; Raddassi K; Hernandez SF; Bassil R; Croci DO; Cerliani JP; Delacour D; Wang Y; Elyaman W; Khoury SJ; Rabinovich GA. 2012. Galectin-1 deactivates classically activated microglia and protects from inflammation-induced neurodegeneration. Immunity 37(2):249-63. [PubMed: 22884314]  [MGI Ref ID J:187374]

Szebeni GJ; Kriston-Pal E; Blazso P; Katona RL; Novak J; Szabo E; Czibula A; Fajka-Boja R; Hegyi B; Uher F; Krenacs L; Joo G; Monostori E. 2012. Identification of galectin-1 as a critical factor in function of mouse mesenchymal stromal cell-mediated tumor promotion. PLoS One 7(7):e41372. [PubMed: 22844466]  [MGI Ref ID J:189723]

Thijssen VL; Barkan B; Shoji H; Aries IM; Mathieu V; Deltour L; Hackeng TM; Kiss R; Kloog Y; Poirier F; Griffioen AW. 2010. Tumor Cells Secrete Galectin-1 to Enhance Endothelial Cell Activity. Cancer Res 70(15):6216-6224. [PubMed: 20647324]  [MGI Ref ID J:162228]

Thijssen VL; Postel R; Brandwijk RJ; Dings RP; Nesmelova I; Satijn S; Verhofstad N; Nakabeppu Y; Baum LG; Bakkers J; Mayo KH; Poirier F; Griffioen AW. 2006. Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy. Proc Natl Acad Sci U S A 103(43):15975-80. [PubMed: 17043243]  [MGI Ref ID J:147258]

Toscano MA; Bianco GA; Ilarregui JM; Croci DO; Correale J; Hernandez JD; Zwirner NW; Poirier F; Riley EM; Baum LG; Rabinovich GA. 2007. Differential glycosylation of T(H)1, T(H)2 and T(H)-17 effector cells selectively regulates susceptibility to cell death. Nat Immunol 8(8):825-834. [PubMed: 17589510]  [MGI Ref ID J:123416]

Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, these mice are bred as homozygotes.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2140.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2782.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We willfulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice
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Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Strain(s) not available to companies or for-profit entities.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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