Strain Name:

B6.Cg-Lgals3tm1Poi/J

Stock Number:

006338

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Availability:

Repository- Live

Use Restrictions Apply, see Terms of Use
Homozygotes carrying the lectin, galactose binding, soluble 3 (Lgals3) knock-out have an impaired acute inflammation response, chondrocyte differentiation during long bone development and myofibroblast activation. This mutant mouse strain may be useful in studies of bone development, endochondral ossification, inflammatory response, and liver fibrosis.

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   15-MAY-08
Specieslaboratory mouse
GenerationN5+N2F2 (10-DEC-13)
Generation Definitions
 
Donating Investigator Richard D. Cummings,   University of Oklahoma

Description
Homozygous mutant mice are viable, fertile, normal in size and do not display any gross physical or behavoiral abnormalities. No gene product (mRNA or protein) is detected by in situ hybridization of tibia bones sections from embryonic day 16.4 mice or by immunohistological staining of fetal skin. Homozygotes have an impaired acute inflammation response. Initial inflammatory infiltrate cell recruitment is normal, but four days after intraperitoneal injection of thioglycollate, mutant mice have a four-fold lower number of recruited granulocytes. Mutant mice have impaired chondrocyte differentiation during long bone development. Fewer hypertrophic chondrocytes but more empty lacunae and condensed chondrocytes are found in the chondrovascular junction. Chondrocytes, cartilage matrix and lacunae are morphologically abnormal. Carbon tetrachloride-induced liver fibrosis results in reduced collagen deposition when compared to wildtype controls. Mutant mice also display defective myofibroblast activation. This mutant mouse strain may be useful in studies of bone development, endochondral ossification, inflammatory response, and liver fibrosis.

This strain was transferred from the Consortium for Functional Glycomics strain collection.

It has been the experience of The Jackson Laboratory that these mice experience a transient period of hairloss between the ages of 2-6 weeks, with full hair growth returning by six weeks of age. Analysis of skin sections reveals a pathology similar to what is seen in C57BL/6 alopecia and movement of these alleles onto the C57BL/6J background may have exacerbated this phenotype.

Development
A targeting vector containing neomycin resistance and herpes simplex virus thymidine kinase genes was used to disrupt 3.7kb of sequence that includes exons 2, 3 and 4. The construct was electroporated into WW6 embryonic stem (ES) cells (derived from 129/Sv, C57BL/6, SJL mixed background mice). Correctly targeted ES cells were injected into outbred MF-1 blastocysts. The resulting chimeric male animals were crossed to 129 female mice. Heterozygotes were crossed to generate homozygotes. The mice were then bred to mice homozygous for a targeted mutation of Lgals1, and he double mutant strain was backcrossed to C57BL/6 for 5 generations. Upon arrival at The Jackson Laboratory, the Lgals1mutation was removed by selective breeding; therefore this strain carries only the Lgals3tm1Poi allele.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Lgals3tm1Poi allele
006354   B6.Cg-Lgals3tm1Poi Lgals1tm1Rob/J
View Strains carrying   Lgals3tm1Poi     (1 strain)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Lgals3tm1Poi/Lgals3tm1Poi

        involves: 129 * 129/Sv * C57BL/6J * SJL
  • mortality/aging
  • *normal* mortality/aging
    • mice exhibit a normal lifespan   (MGI Ref ID J:47227)
  • reproductive system phenotype
  • *normal* reproductive system phenotype
    • mice exhibit normal reproduction   (MGI Ref ID J:47227)
  • integument phenotype
  • *normal* integument phenotype
    • mice exhibit normal skin structure   (MGI Ref ID J:47227)

Lgals3tm1Poi/Lgals3tm1Poi

        involves: 129/Sv * C57BL/6 * SJL
  • mortality/aging
  • increased sensitivity to induced morbidity/mortality
    • mice infected with S. pneumoniae exhibit high mortality after 24 hours   (MGI Ref ID J:131407)
  • immune system phenotype
  • abnormal macrophage physiology
    • macrophage activation by IL-4 and IL-13 stimulation Is impaired   (MGI Ref ID J:131971)
    • however, macrophage activation by IFN-gamma and LPS is normal   (MGI Ref ID J:131971)
    • impaired macrophage chemotaxis
      • when stimulated by IL-4 and IL-13   (MGI Ref ID J:131971)
    • impaired macrophage phagocytosis
      • phagocytosis of apoptotic neutrophils by bone marrow-derived macrophages is impaired   (MGI Ref ID J:131407)
      • however, phagocytosis of S. pneumonia is normal   (MGI Ref ID J:131407)
  • impaired neutrophil recruitment
    • 15 hours after infection with S. pneumoniae   (MGI Ref ID J:131407)
    • however, myeloperoxidase activity is similar to in wild-type mice 15 hours after infection with S. pneumoniae   (MGI Ref ID J:131407)
  • increased interleukin-6 secretion
    • 15 hours after infection with S. pneumoniae, IL-6 concentration in bronchoalveolar lavage is increased compared to in wild-type mice   (MGI Ref ID J:131407)
  • increased susceptibility to bacterial infection
    • mice infected with S. pneumoniae exhibit high mortality after 24 hours   (MGI Ref ID J:131407)
    • after 15 hours, mice infected with S. pneumoniae exhibit increased cell infiltrate but decreased total cell counts in the lungs and develop severe pneumonia with increased lung injury and septicemia compared to wild-type mice   (MGI Ref ID J:131407)
    • after 15 hours, mice infected with S. pneumoniae exhibit a 450-fold increase in bacterial load compared to wild-type mice and blood cultures indicate 100 % bacteremia compared to 30% in wild-type mice   (MGI Ref ID J:131407)
  • increased tumor necrosis factor secretion
    • 15 hours after infection with S. pneumoniae, TNF-alpha concentration in bronchoalveolar lavage is increased compared to in wild-type mice   (MGI Ref ID J:131407)
  • lung inflammation
    • after 15 hours, mice infected with S. pneumoniae exhibit increased cell infiltrate in the lungs and develop severe pneumonia with increased lung injury and septicemia compared to wild-type mice   (MGI Ref ID J:131407)
  • sepsis
    • after 15 hours, mice infected with S. pneumoniae exhibit septicemia unlike wild-type mice   (MGI Ref ID J:131407)
  • skeleton phenotype
  • abnormal long bone epiphyseal plate morphology
    • unlike in wild-type mice, a large zone of empty lacunae is observed between the last row of hypertrophic cells and the vascular invasion front   (MGI Ref ID J:66902)
    • abnormal long bone hypertrophic chondrocyte zone
      • chondrocytes within the hypertrophic zone are larger and more vacuolated than in wild-type mice   (MGI Ref ID J:66902)
      • mice exhibit an increased number of nonhypertrophic cells in the late hyprtrophic zone compared to in wild-type mice   (MGI Ref ID J:66902)
      • chondrocytes in the zone contain unusually large intracellular glycogen aggregates   (MGI Ref ID J:66902)
      • decreased width of hypertrophic chondrocyte zone
        • the hypertrophic zone is reduced in size and contains 20% fewer hypertrophic cells than in wild type mice   (MGI Ref ID J:66902)
  • renal/urinary system phenotype
  • abnormal kidney physiology
    • mice exhibit less renal fibrosis following unilateral ureter obstruction (UUO) compared to wild-type mice   (MGI Ref ID J:131371)
    • however, macrophage recruitment and cytokine production induced by UUO is normal   (MGI Ref ID J:131371)
  • respiratory system phenotype
  • lung inflammation
    • after 15 hours, mice infected with S. pneumoniae exhibit increased cell infiltrate in the lungs and develop severe pneumonia with increased lung injury and septicemia compared to wild-type mice   (MGI Ref ID J:131407)
  • homeostasis/metabolism phenotype
  • decreased susceptibility to injury
    • mice exhibit less renal fibrosis following unilateral ureter obstruction (UUO) compared to wild-type mice   (MGI Ref ID J:131371)
    • however, macrophage recruitment and cytokine production induced by UUO is normal   (MGI Ref ID J:131371)
  • cellular phenotype
  • impaired macrophage chemotaxis
    • when stimulated by IL-4 and IL-13   (MGI Ref ID J:131971)
  • hematopoietic system phenotype
  • abnormal macrophage physiology
    • macrophage activation by IL-4 and IL-13 stimulation Is impaired   (MGI Ref ID J:131971)
    • however, macrophage activation by IFN-gamma and LPS is normal   (MGI Ref ID J:131971)
    • impaired macrophage chemotaxis
      • when stimulated by IL-4 and IL-13   (MGI Ref ID J:131971)
    • impaired macrophage phagocytosis
      • phagocytosis of apoptotic neutrophils by bone marrow-derived macrophages is impaired   (MGI Ref ID J:131407)
      • however, phagocytosis of S. pneumonia is normal   (MGI Ref ID J:131407)
  • impaired neutrophil recruitment
    • 15 hours after infection with S. pneumoniae   (MGI Ref ID J:131407)
    • however, myeloperoxidase activity is similar to in wild-type mice 15 hours after infection with S. pneumoniae   (MGI Ref ID J:131407)

Lgals3tm1Poi/Lgals3tm1Poi

        involves: 129/Sv * C57BL/6 * MF1 * SJL
  • hematopoietic system phenotype
  • decreased granulocyte number
    • while recruitment of granulocytes following treatment with thioglycolate is normal, granulocyte numbers 3 to 4 days after treatment are reduced 4-fold compared to in wild-type mice   (MGI Ref ID J:110422)
    • however, granulocyte apoptosis rates and phagocytosis of apoptotic granulocytes are normal   (MGI Ref ID J:110422)
  • immune system phenotype
  • decreased granulocyte number
    • while recruitment of granulocytes following treatment with thioglycolate is normal, granulocyte numbers 3 to 4 days after treatment are reduced 4-fold compared to in wild-type mice   (MGI Ref ID J:110422)
    • however, granulocyte apoptosis rates and phagocytosis of apoptotic granulocytes are normal   (MGI Ref ID J:110422)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Developmental Biology Research
Skeletal Defects

Immunology, Inflammation and Autoimmunity Research
Inflammation

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Lgals3tm1Poi
Allele Name targeted mutation 1, Francoise Poirier
Allele Type Targeted (Null/Knockout)
Common Name(s) GaL3-; galectin 3-;
Mutation Made By Richard Cummings,   University of Oklahoma
Strain of OriginSTOCK 129/Sv and C57BL/6J and SJL
ES Cell Line NameWW6
ES Cell Line StrainSTOCK 129/Sv and C57BL/6J and SJL
Gene Symbol and Name Lgals3, lectin, galactose binding, soluble 3
Chromosome 14
Gene Common Name(s) CBP35; GAL3; GALBP; GALIG; L-34; L31; LGALS2; MAC2; Mac-2; gal-3; galectin-3;
Molecular Note 3.7kb of sequence, encompassing exons 2 through 4, was replaced via the insertion of a neomycin selection cassette. Immunostaining of fetal skin showed an absence of protein in homozygous mutant embryos. [MGI Ref ID J:47227]

Genotyping

Genotyping Information

Genotyping Protocols

Lgals3tm1Poi, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Colnot C; Fowlis D; Ripoche MA; Bouchaert I; Poirier F. 1998. Embryonic implantation in galectin 1/galectin 3 double mutant mice. Dev Dyn 211(4):306-13. [PubMed: 9566950]  [MGI Ref ID J:47227]

Additional References

Lgals3tm1Poi related

Bermejo DA; Jackson SW; Gorosito-Serran M; Acosta-Rodriguez EV; Amezcua-Vesely MC; Sather BD; Singh AK; Khim S; Mucci J; Liggitt D; Campetella O; Oukka M; Gruppi A; Rawlings DJ. 2013. Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORgammat and Ahr that leads to IL-17 production by activated B cells. Nat Immunol 14(5):514-22. [PubMed: 23563688]  [MGI Ref ID J:196434]

Bischoff V; Deogracias R; Poirier F; Barde YA. 2012. Seizure-induced neuronal death is suppressed in the absence of the endogenous lectin Galectin-1. J Neurosci 32(44):15590-600. [PubMed: 23115194]  [MGI Ref ID J:192288]

Breuilh L; Vanhoutte F; Fontaine J; van Stijn CM; Tillie-Leblond I; Capron M; Faveeuw C; Jouault T; van Die I; Gosset P; Trottein F. 2007. Galectin-3 modulates immune and inflammatory responses during helminthic infection: impact of galectin-3 deficiency on the functions of dendritic cells. Infect Immun 75(11):5148-57. [PubMed: 17785480]  [MGI Ref ID J:126353]

Chiu MG; Johnson TM; Woolf AS; Dahm-Vicker EM; Long DA; Guay-Woodford L; Hillman KA; Bawumia S; Venner K; Hughes RC; Poirier F; Winyard PJ. 2006. Galectin-3 associates with the primary cilium and modulates cyst growth in congenital polycystic kidney disease. Am J Pathol 169(6):1925-38. [PubMed: 17148658]  [MGI Ref ID J:116210]

Colnot C; Ripoche MA; Milon G; Montagutelli X; Crocker PR; Poirier F. 1998. Maintenance of granulocyte numbers during acute peritonitis is defective in galectin-3-null mutant mice. Immunology 94(3):290-6. [PubMed: 9767409]  [MGI Ref ID J:110422]

Colnot C; Ripoche MA; Scaerou F; Foulis D; Poirier F. 1996. Galectins in mouse embryogenesis. Biochem Soc Trans 24(1):141-6. [PubMed: 8674632]  [MGI Ref ID J:31899]

Colnot C; Sidhu SS; Balmain N; Poirier F. 2001. Uncoupling of chondrocyte death and vascular invasion in mouse galectin 3 null mutant bones. Dev Biol 229(1):203-14. [PubMed: 11133164]  [MGI Ref ID J:66902]

Comte I; Kim Y; Young CC; van der Harg JM; Hockberger P; Bolam PJ; Poirier F; Szele FG. 2011. Galectin-3 maintains cell motility from the subventricular zone to the olfactory bulb. J Cell Sci 124(Pt 14):2438-47. [PubMed: 21693585]  [MGI Ref ID J:183042]

Delacour D; Koch A; Ackermann W; Eude-Le Parco I; Elsasser HP; Poirier F; Jacob R. 2008. Loss of galectin-3 impairs membrane polarisation of mouse enterocytes in vivo. J Cell Sci 121(Pt 4):458-65. [PubMed: 18211959]  [MGI Ref ID J:138282]

Doverhag C; Hedtjarn M; Poirier F; Mallard C; Hagberg H; Karlsson A; Savman K. 2010. Galectin-3 contributes to neonatal hypoxic-ischemic brain injury. Neurobiol Dis 38(1):36-46. [PubMed: 20053377]  [MGI Ref ID J:159938]

Dragomir AC; Sun R; Choi H; Laskin JD; Laskin DL. 2012. Role of Galectin-3 in Classical and Alternative Macrophage Activation in the Liver following Acetaminophen Intoxication. J Immunol 189(12):5934-41. [PubMed: 23175698]  [MGI Ref ID J:190845]

Dragomir AC; Sun R; Mishin V; Hall LB; Laskin JD; Laskin DL. 2012. Role of galectin-3 in acetaminophen-induced hepatotoxicity and inflammatory mediator production. Toxicol Sci 127(2):609-19. [PubMed: 22461450]  [MGI Ref ID J:185729]

Farnworth SL; Henderson NC; Mackinnon AC; Atkinson KM; Wilkinson T; Dhaliwal K; Hayashi K; Simpson AJ; Rossi AG; Haslett C; Sethi T. 2008. Galectin-3 reduces the severity of pneumococcal pneumonia by augmenting neutrophil function. Am J Pathol 172(2):395-405. [PubMed: 18202191]  [MGI Ref ID J:131407]

Henderson NC; Mackinnon AC; Farnworth SL; Kipari T; Haslett C; Iredale JP; Liu FT; Hughes J; Sethi T. 2008. Galectin-3 expression and secretion links macrophages to the promotion of renal fibrosis. Am J Pathol 172(2):288-98. [PubMed: 18202187]  [MGI Ref ID J:131371]

Henderson NC; Mackinnon AC; Farnworth SL; Poirier F; Russo FP; Iredale JP; Haslett C; Simpson KJ; Sethi T. 2006. Galectin-3 regulates myofibroblast activation and hepatic fibrosis. Proc Natl Acad Sci U S A 103(13):5060-5. [PubMed: 16549783]  [MGI Ref ID J:107656]

Lalancette-Hebert M; Swarup V; Beaulieu JM; Bohacek I; Abdelhamid E; Weng YC; Sato S; Kriz J. 2012. Galectin-3 is required for resident microglia activation and proliferation in response to ischemic injury. J Neurosci 32(30):10383-95. [PubMed: 22836271]  [MGI Ref ID J:186539]

MacKinnon AC; Farnworth SL; Hodkinson PS; Henderson NC; Atkinson KM; Leffler H; Nilsson UJ; Haslett C; Forbes SJ; Sethi T. 2008. Regulation of alternative macrophage activation by galectin-3. J Immunol 180(4):2650-8. [PubMed: 18250477]  [MGI Ref ID J:131971]

Mishra BB; Li Q; Steichen AL; Binstock BJ; Metzger DW; Teale JM; Sharma J. 2013. Galectin-3 functions as an alarmin: pathogenic role for sepsis development in murine respiratory tularemia. PLoS One 8(3):e59616. [PubMed: 23527230]  [MGI Ref ID J:199906]

Nachtigal M; Ghaffar A; Mayer EP. 2008. Galectin-3 gene inactivation reduces atherosclerotic lesions and adventitial inflammation in ApoE-deficient mice. Am J Pathol 172(1):247-55. [PubMed: 18156214]  [MGI Ref ID J:130923]

Oakley MS; Majam V; Mahajan B; Gerald N; Anantharaman V; Ward JM; Faucette LJ; McCutchan TF; Zheng H; Terabe M; Berzofsky JA; Aravind L; Kumar S. 2009. Pathogenic roles of CD14, galectin-3, and OX40 during experimental cerebral malaria in mice. PLoS One 4(8):e6793. [PubMed: 19710907]  [MGI Ref ID J:152399]

Pang J; Rhodes DH; Pini M; Akasheh RT; Castellanos KJ; Cabay RJ; Cooper D; Perretti M; Fantuzzi G. 2013. Increased adiposity, dysregulated glucose metabolism and systemic inflammation in Galectin-3 KO mice. PLoS One 8(2):e57915. [PubMed: 23451284]  [MGI Ref ID J:197183]

Saint-Lu N; Oortwijn BD; Pegon JN; Odouard S; Christophe OD; de Groot PG; Denis CV; Lenting PJ. 2012. Identification of galectin-1 and galectin-3 as novel partners for von Willebrand factor. Arterioscler Thromb Vasc Biol 32(4):894-901. [PubMed: 22267483]  [MGI Ref ID J:195956]

Shan M; Gentile M; Yeiser JR; Walland AC; Bornstein VU; Chen K; He B; Cassis L; Bigas A; Cols M; Comerma L; Huang B; Blander JM; Xiong H; Mayer L; Berin C; Augenlicht LH; Velcich A; Cerutti A. 2013. Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals. Science 342(6157):447-53. [PubMed: 24072822]  [MGI Ref ID J:202829]

Van den Bossche J; Bogaert P; van Hengel J; Guerin CJ; Berx G; Movahedi K; Van den Bergh R; Pereira-Fernandes A; Geuns JM; Pircher H; Dorny P; Grooten J; De Baetselier P; Van Ginderachter JA. 2009. Alternatively activated macrophages engage in homotypic and heterotypic interactions through IL-4 and polyamine-induced E-cadherin/catenin complexes. Blood 114(21):4664-74. [PubMed: 19726720]  [MGI Ref ID J:155503]

Young CC; Al-Dalahmah O; Lewis NJ; Brooks KJ; Jenkins MM; Poirier F; Buchan AM; Szele FG. 2014. Blocked angiogenesis in Galectin-3 null mice does not alter cellular and behavioral recovery after middle cerebral artery occlusion stroke. Neurobiol Dis 63:155-64. [PubMed: 24269916]  [MGI Ref ID J:210375]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX10

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, these mice are bred as homozygotes.
Mating SystemHomozygote x Homozygote         (Female x Male)   15-MAY-08
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $199.90Female or MaleHomozygous for Lgals3tm1Poi  
Price per Pair (US dollars $)Pair Genotype
$399.80Homozygous for Lgals3tm1Poi x Homozygous for Lgals3tm1Poi  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $259.90Female or MaleHomozygous for Lgals3tm1Poi  
Price per Pair (US dollars $)Pair Genotype
$519.80Homozygous for Lgals3tm1Poi x Homozygous for Lgals3tm1Poi  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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