Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Background Strain NOD/ShiLtJ Donor Strain 129S4 (J1 ES cell) H2 Haplotype g7 Generation N2F3p Generation Definitions   Donating Investigator Stephan Martin,   Dusseldorf at the Heinrich-Heine-Univers

Description
Homozygous mutant mice are diabetes resistant. No membrane bound ICAM-1 is detectable in homozygous mutant mice. Histological examination shows no or only mild peri-insular infiltration at 330-410 days of age, By comparison, 64% of their wild-type and 44% of their heterozygote cohorts become diabetic by 310 days of age. In contrast to wild-type, 110-day-old ICAM-1 deficient females do not develop severe insulitis 10 days post cyclophosphamide treatment. Protection is associated with suppression of destructive insulitis as well as a deviation to a T-helper 2 cytokine mRNA expression pattern (Martin et al 2001).

Both the C57BL/6 contaminated strain, Stock No. 005983 - NOD.129S4(B6)-Icam1^tm1Jcgr/SmtnJ, and this non contaminated strain are completly diabetes resistant at 30 weeks of age when evaluated in a comparative diabetes incidence study. Fine mapping data may be viewed at GQC of Icam1 congenic stocks

This targeted mutant strain is useful for studying the ICAM-1/LAF-1 interaction and its role in diabetes.

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

Development
Intercellular adhesion molecule 1 (Icam1), located on Chr 9, 7cM, contains 7 exons and is one of the immunoglobulin superfamily that binds to the integrins LFA-1 and Mac-1 on leukocytes. A neomycin resistance cassette was inserted into exon 4 (one of the 5 Ig-like extracellular domains) of the Icam1 gene. J1 ES cell clone 74 was injected into B6 blastocysts. This Icam1 mutation has been backcrossed to NOD for at least 6 generations (Martin et al, 2001). The Type 1 Diabetes Resource received Stock No. 005983 - NOD.129S4(B6)-Icam1^tm1Jcgr/SmtnJ in 2005. Shortly after arriving at The Jackson Laboratory additional genetic quality control indicated C57BL/6 genomic contamination on Chr 6 and 7. Markers D6Mit178, D6Mit52 and D6Mit135 on Chr 6 were segregating for both NOD and C57BL/6. Through selective breeding the Chr. 6 markers are NOD in origin. Markers D7Mit139, D7Mit96 and D7Mit328 on Chr 7 were found to be of C57BL/6 origin. After 2 crosses to NOD/ShiLtJ, all three Chr 7 markers were homozygous for the NOD-derived alleles. In 2007, this strain is at generation N?+N2F2.

Control Information

	Control
	001976 NOD/ShiLtJ
Considerations for Choosing Controls

Related Strains

Strains carrying   Icam1^tm1Jcgr allele

002867	B6.129S4-Icam1tm1Jcgr/J
005983	NOD.129S4(B6)-Icam1tm1Jcgr/SmtnJ

View Strains carrying   Icam1^tm1Jcgr     (2 strains)

Strains carrying other alleles of Icam1

002867	B6.129S4-Icam1tm1Jcgr/J
002285	B6.129S7-Icam1tm1Bay Selptm1Bay/J
002127	B6.129S7-Icam1tm1Bay/J
005983	NOD.129S4(B6)-Icam1tm1Jcgr/SmtnJ

View Strains carrying other alleles of Icam1     (4 strains)

Phenotype

Phenotype Information

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Immunology and Inflammation Research
Autoimmunity
      Type 1 Diabetes
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Inflammation

Icam1^tm1Jcgr related

Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
Inflammation

Internal/Organ Research
Wound Healing
      delayed/impaired

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol		Icam1tm1Jcgr
Allele Name		targeted mutation 1, Jose Carlos Gutierrez Ramos
Allele Type		Targeted (knock-out)
Common Name(s)		ICAM-1-; ICAM-1-deficient; ICAMtm1-jcgr;
Mutation Made By		Jose-Carlos Gutierrez-Ramos,   Millenium Pharmaceuticals
Strain of Origin		129S4/SvJae
ES Cell Line Name		J1
ES Cell Line Strain		129S4/SvJae
Gene Symbol and Name		Icam1, intercellular adhesion molecule 1
Chromosome		9
Gene Common Name(s)		BB2; CD54; ICAM; Icam-1; Ly-47; MALA-2; MGC:6195; P3.58; lymphocyte antigen 47;
Molecular Note		A neomycin resistance cassette was inserted into exon 4 of the gene. While King, et. al. (J:25530) reported the potential for the production of functional proteins arising from alternative transcripts, corresponding signals were undetected by immunohistochemical analysis of homozygous mutant mice. [MGI Ref ID J:18743]

Genotyping

Genotyping Information

Genotyping Protocols

Icam1^tm1Jcgr, Standard PCR

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Martin S; van Den Engel NK; Vinke A; Heidenthal E; Schulte B; Kolb H. 2001. Dominant role of intercellular adhesion molecule-1 in the pathogenesis of autoimmune diabetes in non-obese diabetic mice. J Autoimmun 17(2):109-17. [PubMed: 11591119]  [MGI Ref ID J:71827]

Additional References

Icam1^tm1Jcgr related

Aoudjit F; Potworowski EF; Springer TA; St-Pierre Y. 1998. Protection from lymphoma cell metastasis in ICAM-1 mutant mice: a posthoming event. J Immunol 161(5):2333-8. [PubMed: 9725228]  [MGI Ref ID J:49717]

Balasa B; La Cava A; Van Gunst K; Mocnik L; Balakrishna D; Nguyen N; Tucker L; Sarvetnick N. 2000. A mechanism for IL-10-mediated diabetes in the nonobese diabetic (NOD) mouse: ICAM-1 deficiency blocks accelerated diabetes J Immunol 165(12):7330-7. [PubMed: 11120869]  [MGI Ref ID J:66103]

Calderon B; Carrero JA; Miller MJ; Unanue ER. 2011. Cellular and molecular events in the localization of diabetogenic T cells to islets of Langerhans. Proc Natl Acad Sci U S A 108(4):1561-6. [PubMed: 21220322]  [MGI Ref ID J:168246]

Calderon B; Carrero JA; Miller MJ; Unanue ER. 2011. Entry of diabetogenic T cells into islets induces changes that lead to amplification of the cellular response. Proc Natl Acad Sci U S A 108(4):1567-72. [PubMed: 21220309]  [MGI Ref ID J:168247]

Chen Q; Fisher DT; Clancy KA; Gauguet JM; Wang WC; Unger E; Rose-John S; von Andrian UH; Baumann H; Evans SS. 2006. Fever-range thermal stress promotes lymphocyte trafficking across high endothelial venules via an interleukin 6 trans-signaling mechanism. Nat Immunol 7(12):1299-1308. [PubMed: 17086187]  [MGI Ref ID J:116128]

Cybulsky MI; Iiyama K; Li H; Zhu S; Chen M; Iiyama M; Davis V; Gutierrez-Ramos JC; Connelly PW; Milstone DS. 2001. A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J Clin Invest 107(10):1255-62. [PubMed: 11375415]  [MGI Ref ID J:69597]

Dautigny N; Le Campion A; Lucas B. 1999. Timing and casting for actors of thymic negative selection. J Immunol 162(3):1294-302. [PubMed: 9973382]  [MGI Ref ID J:124433]

Davani EY; Boyd JH; Dorscheid DR; Wang Y; Meredith A; Chau E; Singhera GK; Walley KR. 2006. Cardiac ICAM-1 mediates leukocyte-dependent decreased ventricular contractility in endotoxemic mice. Cardiovasc Res 72(1):134-42. [PubMed: 16934241]  [MGI Ref ID J:114093]

Demers M; Magnaldo T; St-Pierre Y. 2005. A novel function for galectin-7: promoting tumorigenesis by up-regulating MMP-9 gene expression. Cancer Res 65(12):5205-10. [PubMed: 15958565]  [MGI Ref ID J:99384]

Dong ZM; Gutierrez-Ramos JC; Coxon A; Mayadas TN; Wagner DD. 1997. A new class of obesity genes encodes leukocyte adhesion receptors. Proc Natl Acad Sci U S A 94(14):7526-30. [PubMed: 9207125]  [MGI Ref ID J:41751]

Feuillet V; Lucas B; Di Santo JP; Bismuth G; Trautmann A. 2005. Multiple survival signals are delivered by dendritic cells to naive CD4+ T cells. Eur J Immunol 35(9):2563-72. [PubMed: 16078277]  [MGI Ref ID J:113487]

Frommhold D; Kamphues A; Hepper I; Pruenster M; Lukic IK; Socher I; Zablotskaya V; Buschmann K; Lange-Sperandio B; Schymeinsky J; Ryschich E; Poeschl J; Kupatt C; Nawroth PP; Moser M; Walzog B; Bierhaus A; Sperandio M. 2010. RAGE and ICAM-1 cooperate in mediating leukocyte recruitment during acute inflammation in vivo. Blood 116(5):841-9. [PubMed: 20407037]  [MGI Ref ID J:163511]

Frossard JL; Saluja A; Bhagat L; Lee HS; Bhatia M; Hofbauer B; Steer ML. 1999. The role of intercellular adhesion molecule 1 and neutrophils in acute pancreatitis and pancreatitis-associated lung injury. Gastroenterology 116(3):694-701. [PubMed: 10029629]  [MGI Ref ID J:107680]

Gonzalo JA; Martinez C; Springer TA; Gutierrez-Ramos JC. 1995. ICAM-1 is required for T cell proliferation but not for anergy or apoptosis induced by Staphylococcus aureus enterotoxin B in vivo. Int Immunol 7(10):1691-8. [PubMed: 8562515]  [MGI Ref ID J:29453]

Gujral JS; Liu J; Farhood A; Hinson JA; Jaeschke H. 2004. Functional importance of ICAM-1 in the mechanism of neutrophil-induced liver injury in bile duct-ligated mice. Am J Physiol Gastrointest Liver Physiol 286(3):G499-507. [PubMed: 14563671]  [MGI Ref ID J:95678]

Hirahashi J; Mekala D; Van Ziffle J; Xiao L; Saffaripour S; Wagner DD; Shapiro SD; Lowell C; Mayadas TN. 2006. Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy. Immunity 25(2):271-83. [PubMed: 16872848]  [MGI Ref ID J:113463]

Hu X; Barnum SR; Wohler JE; Schoeb TR; Bullard DC. 2010. Differential ICAM-1 isoform expression regulates the development and progression of experimental autoimmune encephalomyelitis. Mol Immunol 47(9):1692-700. [PubMed: 20371120]  [MGI Ref ID J:160627]

Karsten CM; Behrends J; Wagner AK; Fuchs F; Figge J; Schmudde I; Hellberg L; Kruse A. 2009. DC within the pregnant mouse uterus influence growth and functional properties of uterine NK cells. Eur J Immunol 39(8):2203-14. [PubMed: 19593769]  [MGI Ref ID J:151694]

Kelly KJ; Williams WW Jr.; Colvin RB; Meehan SM; Springer TA; Gutierrez-Ramos JC; Bonventre JV. 1996. Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury. J Clin Invest 97(4):1056-63. [PubMed: 8613529]  [MGI Ref ID J:31435]

King PD; Sandberg ET; Selvakumar A; Fang P; Beaudet AL; Dupont B. 1995. Novel isoforms of murine intercellular adhesion molecule-1 generated by alternative RNA splicing. J Immunol 154(11):6080-6093. [PubMed: 7751650]  [MGI Ref ID J:25530]

Kociok N; Radetzky S; Krohne TU; Gavranic C; Liang Y; Semkova I; Joussen AM. 2009. ICAM-1 depletion does not alter retinal vascular development in a model of oxygen-mediated neovascularization. Exp Eye Res 89(4):503-10. [PubMed: 19482023]  [MGI Ref ID J:154501]

Kupatt C; Wichels R; Horstkotte J; Krombach F; Habazettl H; Boekstegers P. 2002. Molecular mechanisms of platelet-mediated leukocyte recruitment during myocardial reperfusion. J Leukoc Biol 72(3):455-61. [PubMed: 12223512]  [MGI Ref ID J:124451]

Lloyd CM; Gonzalo JA; Salant DJ; Just J; Gutierrez-Ramos JC. 1997. Intercellular adhesion molecule-1 deficiency prolongs survival and protects against the development of pulmonary inflammation during murine lupus. J Clin Invest 100(5):963-71. [PubMed: 9276713]  [MGI Ref ID J:111466]

Lyck R; Reiss Y; Gerwin N; Greenwood J; Adamson P; Engelhardt B. 2003. T-cell interaction with ICAM-1/ICAM-2 double-deficient brain endothelium in vitro: the cytoplasmic tail of endothelial ICAM-1 is necessary for transendothelial migration of T cells. Blood 102(10):3675-83. [PubMed: 12893765]  [MGI Ref ID J:86457]

Martin S; Vinke A; Heidenthal E; Schulte B; van den Engel N. 1999. Development of low-dose streptozotocin-induced diabetes in ICAM-1-deficient mice. Horm Metab Res 31(12):636-40. [PubMed: 10668914]  [MGI Ref ID J:59947]

Mathew B; Park GY; Cao H; Azim AC; Wang X; Van Breemen RB; Sadikot RT; Christman JW. 2007. Inhibitory kappaB kinase 2 activates airway epithelial cells to stimulate bone marrow macrophages. Am J Respir Cell Mol Biol 36(5):562-72. [PubMed: 17204585]  [MGI Ref ID J:136649]

Moreira AP; Campanelli AP; Cavassani KA; Souto JT; Ferreira BR; Martinez R; Rossi MA; Silva JS. 2006. Intercellular adhesion molecule-1 is required for the early formation of granulomas and participates in the resistance of mice to the infection with the fungus Paracoccidioides brasiliensis. Am J Pathol 169(4):1270-81. [PubMed: 17003484]  [MGI Ref ID J:113377]

Oliveira-dos-Santos AJ; Penninger JM; Rieker-Geley T; Matsumoto G; Mak TM; Wick G. 1998. Thymic heterotypic cellular complexes in gene-targeted mice with defined blocks in T cell development and adhesion molecule expression. Eur J Immunol 28(9):2882-92. [PubMed: 9754575]  [MGI Ref ID J:49877]

Parameswaran N; Suresh R; Bal V; Rath S; George A. 2005. Lack of ICAM-1 on APCs during T cell priming leads to poor generation of central memory cells. J Immunol 175(4):2201-11. [PubMed: 16081787]  [MGI Ref ID J:107514]

Perkowski S; Scherpereel A; Murciano JC; Arguiri E; Solomides CC; Albelda SM; Muzykantov V; Christofidou-Solomidou M. 2006. Dissociation between alveolar transmigration of neutrophils and lung injury in hyperoxia. Am J Physiol Lung Cell Mol Physiol 291(5):L1050-8. [PubMed: 16815892]  [MGI Ref ID J:144691]

Planck SR; Han YB; Park JM; O'Rourke L; Gutierrez-Ramos JC; Rosenbaum JT. 1998. The effect of genetic deficiency of adhesion molecules on the course of endotoxin-induced uveitis. Curr Eye Res 17(9):941-6. [PubMed: 9746442]  [MGI Ref ID J:114206]

Ren G; Zhao X; Zhang L; Zhang J; L'Huillier A; Ling W; Roberts AI; Le AD; Shi S; Shao C; Shi Y. 2010. Inflammatory cytokine-induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in mesenchymal stem cells are critical for immunosuppression. J Immunol 184(5):2321-8. [PubMed: 20130212]  [MGI Ref ID J:159645]

Scholer A; Hugues S; Boissonnas A; Fetler L; Amigorena S. 2008. Intercellular adhesion molecule-1-dependent stable interactions between T cells and dendritic cells determine CD8+ T cell memory. Immunity 28(2):258-70. [PubMed: 18275834]  [MGI Ref ID J:132214]

Segura E; Guerin C; Hogg N; Amigorena S; Thery C. 2007. CD8+ dendritic cells use LFA-1 to capture MHC-peptide complexes from exosomes in vivo. J Immunol 179(3):1489-96. [PubMed: 17641014]  [MGI Ref ID J:149952]

Segura E; Nicco C; Lombard B; Veron P; Raposo G; Batteux F; Amigorena S; Thery C. 2005. ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming. Blood 106(1):216-23. [PubMed: 15790784]  [MGI Ref ID J:107454]

Shimada Y; Hasegawa M; Kaburagi Y; Hamaguchi Y; Komura K; Saito E; Takehara K; Steeber DA; Tedder TF; Sato S. 2003. L-selectin or ICAM-1 deficiency reduces an immediate-type hypersensitivity response by preventing mast cell recruitment in repeated elicitation of contact hypersensitivity. J Immunol 170(8):4325-34. [PubMed: 12682269]  [MGI Ref ID J:125436]

Siebert H; Bruck W. 2003. The role of cytokines and adhesion molecules in axon degeneration after peripheral nerve axotomy: a study in different knockout mice. Brain Res 960(1-2):152-6. [PubMed: 12505667]  [MGI Ref ID J:107780]

Soriano SG; Lipton SA; Wang YF; Xiao M; Springer TA; Gutierrez-Ramos JC; Hickey PR. 1996. Intercellular adhesion molecule-1-deficient mice are less susceptible to cerebral ischemia-reperfusion injury. Ann Neurol 39(5):618-24. [PubMed: 8619547]  [MGI Ref ID J:33920]

Steiner O; Coisne C; Cecchelli R; Boscacci R; Deutsch U; Engelhardt B; Lyck R. 2010. Differential roles for endothelial ICAM-1, ICAM-2, and VCAM-1 in shear-resistant T cell arrest, polarization, and directed crawling on blood-brain barrier endothelium. J Immunol 185(8):4846-55. [PubMed: 20861356]  [MGI Ref ID J:164721]

Sumagin R; Lomakina E; Sarelius IH. 2008. Leukocyte-endothelial cell interactions are linked to vascular permeability via ICAM-1-mediated signaling. Am J Physiol Heart Circ Physiol 295(3):H969-H977. [PubMed: 18641276]  [MGI Ref ID J:141283]

Sumagin R; Sarelius IH. 2007. A role for ICAM-1 in maintenance of leukocyte-endothelial cell rolling interactions in inflamed arterioles. Am J Physiol Heart Circ Physiol 293(5):H2786-98. [PubMed: 17704289]  [MGI Ref ID J:132086]

Takaoka N; Campbell LA; Lee A; Rosenfeld ME; Kuo CC. 2008. Chlamydia pneumoniae infection increases adherence of mouse macrophages to mouse endothelial cells in vitro and to aortas ex vivo. Infect Immun 76(2):510-4. [PubMed: 18070891]  [MGI Ref ID J:130335]

Tang T; Rosenkranz A; Assmann KJM; Goodman MJ; Gutierrez-Ramos JC ; Carroll MC ; Cotran RS ; Mayadas TN. 1997. A role for Mac-1 (CDIIb/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcgamma receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis. J Exp Med 186(11):1853-63. [PubMed: 9382884]  [MGI Ref ID J:44403]

TeKippe M; Harrison DE; Chen J. 2003. Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice. Exp Hematol 31(6):521-7. [PubMed: 12829028]  [MGI Ref ID J:115677]

Tommerup N; Schempp W; Meinecke P; Pedersen S; Bolund L; Brandt C; Goodpasture C; Guldberg P; Held KR; Reinwein H; Saugstad OD; Scherer G; Skjeldal O; Toder R; Westvik J; Van der Hagen CB; Wolf U.. 1993. Assignment of an autosomal sex reversal locus (SRA1) and campomelic dysplasia (CMPD1) to 17q24.3-q25.1. Nat Genet 4(2):170-4. [PubMed: 8348155]  [MGI Ref ID J:11820]

Walter MJ; Morton JD; Kajiwara N; Agapov E; Holtzman MJ. 2002. Viral induction of a chronic asthma phenotype and genetic segregation from the acute response. J Clin Invest 110(2):165-75. [PubMed: 12122108]  [MGI Ref ID J:120696]

Wang HW; Babic AM; Mitchell HA; Liu K; Wagner DD. 2005. Elevated soluble ICAM-1 levels induce immune deficiency and increase adiposity in mice. FASEB J 19(8):1018-20. [PubMed: 15817637]  [MGI Ref ID J:128252]

Watts GM; Beurskens FJ; Martin-Padura I; Ballantyne CM; Klickstein LB; Brenner MB; Lee DM. 2005. Manifestations of inflammatory arthritis are critically dependent on LFA-1. J Immunol 174(6):3668-75. [PubMed: 15749905]  [MGI Ref ID J:97703]

Werner A; Martin S; Gutierrez-Ramos JC; Raivich G. 2001. Leukocyte recruitment and neuroglial activation during facial nerve regeneration in ICAM-1-deficient mice: effects of breeding strategy. Cell Tissue Res 305(1):25-41. [PubMed: 11512669]  [MGI Ref ID J:105085]

Windish HP; Lin PL; Mattila JT; Green AM; Onuoha EO; Kane LP; Flynn JL. 2009. Aberrant TGF-beta signaling reduces T regulatory cells in ICAM-1-deficient mice, increasing the inflammatory response to Mycobacterium tuberculosis. J Leukoc Biol 86(3):713-25. [PubMed: 19454651]  [MGI Ref ID J:152430]

Wu X; Guo R; Wang Y; Cunningham PN. 2007. The role of ICAM-1 in endotoxin-induced acute renal failure. Am J Physiol Renal Physiol 293(4):F1262-71. [PubMed: 17670897]  [MGI Ref ID J:145124]

Xiang J; Huang H; Liu Y. 2005. A new dynamic model of CD8+ T effector cell responses via CD4+ T helper-antigen-presenting cells. J Immunol 174(12):7497-505. [PubMed: 15944248]  [MGI Ref ID J:100792]

Xu H; Gonzalo JA; St Pierre Y; Williams IR; Kupper TS; Cotran RS; Springer TA; Gutierrez-Ramos JC. 1994. Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice. J Exp Med 180(1):95-109. [PubMed: 7911822]  [MGI Ref ID J:18743]

Yoshizaki A; Yanaba K; Iwata Y; Komura K; Ogawa A; Akiyama Y; Muroi E; Hara T; Ogawa F; Takenaka M; Shimizu K; Hasegawa M; Fujimoto M; Tedder TF; Sato S. 2010. Cell Adhesion Molecules Regulate Fibrotic Process via Th1/Th2/Th17 Cell Balance in a Bleomycin-Induced Scleroderma Model. J Immunol 185(4):2502-15. [PubMed: 20624949]  [MGI Ref ID J:162381]

van Den Engel NK; Heidenthal E; Vinke A; Kolb H; Martin S. 2000. Circulating forms of intercellular adhesion molecule (ICAM)-1 in mice lacking membranous ICAM-1. Blood 95(4):1350-5. [PubMed: 10666210]  [MGI Ref ID J:110274]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, RG10/RG30.

Purchasing information

Pricing, Supply Level & Notes, Controls

General Supply Notes

• This strain is included in the Type 1 Diabetes Repository collection.

Control Information

	Control
	001976 NOD/ShiLtJ
Considerations for Choosing Controls
Control Pricing Information for Genetically Engineered Mutant Strains.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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