Strain Name:

B6;129-Rab3btm1Sud Rab3atm1Sud Rab3dtm1Rja Rab3ctm1Sud/J

Stock Number:

006375

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Availability:

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Use Restrictions Apply, see Terms of Use
Common Names: quadruple Rab3 KO (ABCD -/-);    
These mice carry targeted mutations in the Rab3a (RAB3A, member RAS oncogene family, Rab3b (RAB3B, member RAS oncogene family), Rab3c (RAB3C, member RAS oncogene family), and Rab3d (RAB3D, member RAS oncogene family) genes. Mice homozygous for all four targeted mutations die shortly after birth due to respiratory problems. Mutant mice display no apparent changes in synapse structure or brain composition except for the loss of rabphilin. The size of the excitatory postsynaptic current (EPSC) induced by action potentials is ~30% smaller in mutant mice as compared to controls. This mutant mouse strain may be useful in studies of synaptic vesicle exocytosis mechanisms in neurons.

Description

Strain Information

Type Mutant Stock; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Specieslaboratory mouse
Generation?+F15 (10-DEC-13)
Generation Definitions
 
Donating InvestigatorDr. Thomas C. Sudhof,   Stanford University School of Medicine

Description
Mice homozygous for all four targeted mutations die shortly after birth due to respiratory problems. No protein products from the targeted genes are detected in brain or pituitary tissue. Mutant mice display no apparent changes in synapse structure or brain composition except for the loss of rabphilin. Analysis of cultures of hippocampal neurons uncovered no significant change in spontaneous or sucrose-evoked release of presynaptic vesicles. The size of the excitatory postsynaptic current (EPSC) induced by action potentials is ~30% smaller in mutant mice as compared to controls. This mutant mouse strain may be useful in studies of synaptic vesicle exocytosis mechanisms in neurons.

Development
Targeting vectors containing a neomycin resistance gene were used to replace homologous exons encoding residues 1-76 of Rab3a, Rab3b, and Rab3d and residues 9-84 of Rab3c genes. The constructs were electroporated independently into 129P2/OlaHsd-derived E14.1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts. Chimeric mice for each mutation were crossed with C57BL/6 mice. Compound targeted mutant mice were generated by intercrossing individual mutant lines. This strain was backcrossed 2 or 3 times to C57BL/6 by the donating investigator prior to arrival at The Jackson Laboratory.

Control Information

  Control
   100903 B6129PF2/J (approximate)
   000664 C57BL/6J (approximate)
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Rab3atm1Sud allele
002443   B6;129S-Rab3atm1Sud/J
View Strains carrying   Rab3atm1Sud     (1 strain)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Rab3atm1Sud/Rab3a+ Rab3btm1Sud/Rab3btm1Sud Rab3ctm1Sud/Rab3ctm1Sud Rab3dtm1Rja/Rab3dtm1Rja

        involves: 129 * 129P2/OlaHsd
  • normal phenotype
  • no abnormal phenotype detected   (MGI Ref ID J:105478)

Rab3atm1Sud/Rab3atm1Sud Rab3btm1Sud/Rab3b+ Rab3ctm1Sud/Rab3ctm1Sud Rab3dtm1Rja/Rab3dtm1Rja

        involves: 129 * 129P2/OlaHsd
  • mortality/aging
  • partial neonatal lethality
    • 50% of triple Rab3 knockouts with one copy of Rab3c survive   (MGI Ref ID J:105478)
  • growth/size/body phenotype
  • decreased body weight
    • male and female triple knockouts which are deficient for Rab3a and heterozygous for Rab3b display a weight decrease at 5 weeks of age   (MGI Ref ID J:105478)
  • respiratory system phenotype
  • respiratory distress
    • triple knockouts lacking Rab3a show respiratory impairment similar to, but less severe than that shown by quadruple knockouts   (MGI Ref ID J:105478)

Rab3atm1Sud/Rab3atm1Sud Rab3btm1Sud/Rab3btm1Sud Rab3ctm1Sud/Rab3c+ Rab3dtm1Rja/Rab3dtm1Rja

        involves: 129 * 129P2/OlaHsd
  • mortality/aging
  • partial neonatal lethality
    • 50% of triple Rab3 knockouts that are heterozygous for Rab3c survive   (MGI Ref ID J:105478)
  • growth/size/body phenotype
  • decreased body weight
    • male and female triple knockouts which are deficient for Rab3a and heterozygous for Rab3c display a weight decrease at 5 weeks of age   (MGI Ref ID J:105478)

Rab3atm1Sud/Rab3atm1Sud Rab3btm1Sud/Rab3btm1Sud Rab3ctm1Sud/Rab3ctm1Sud Rab3dtm1Rja/Rab3d+

        involves: 129 * 129P2/OlaHsd
  • mortality/aging
  • neonatal lethality   (MGI Ref ID J:105478)

Rab3atm1Sud/Rab3atm1Sud Rab3btm1Sud/Rab3btm1Sud Rab3ctm1Sud/Rab3ctm1Sud Rab3dtm1Rja/Rab3dtm1Rja

        involves: 129 * 129P2/OlaHsd
  • mortality/aging
  • complete neonatal lethality
    • quadruple knockouts are born alive and react to stimuli; pups do not have milk in their stomachs and die soon after birth due to respiratory distress   (MGI Ref ID J:105478)
  • homeostasis/metabolism phenotype
  • cyanosis
    • newborn mice are cyanotic   (MGI Ref ID J:105478)
  • nervous system phenotype
  • abnormal CNS synaptic transmission
    • synaptic response (release) in presence of high calcium is potentiated in knockout neurons compared to control   (MGI Ref ID J:104983)
    • abnormal excitatory postsynaptic currents
      • EPSCs induced by action potentials are 30% smaller than in control (Rab3b,c,d triple knockout) animals; Rab3a deficient mice show no decline in EPSC indicating that lack of this isoform is not the sole reason for the decrease observed in quadruple knockouts   (MGI Ref ID J:105478)
      • repetitive stimulation of cultured quadruple knockout neurons induces strong initial facilitation; after ~5 synaptic responses, converged to similar amplitudes with controls   (MGI Ref ID J:104983)
      • EPSCs recover faster in mutant neurons than in control after depletion of the pool of synaptic vesicles   (MGI Ref ID J:104983)
  • decreased neurotransmitter release
    • in neurons, the synaptic release probability of vesicles is reduced by 40% compared to control triple knockout neurons; Rab3a-deficient neurons displayed no difference in release probability from wild-type   (MGI Ref ID J:105478)
  • enhanced paired-pulse facilitation
    • neurons show strong paired-pulse facilitation   (MGI Ref ID J:104983)
  • respiratory system phenotype
  • abnormal breathing pattern
    • newborn mice exhibit shallow and irregular breathing patterns   (MGI Ref ID J:105478)
    • respiratory distress
      • newborn mice exhibit respiratory distress and die soon after birth; if mice are placed in a high oxygen atmosphere, survival time is increased   (MGI Ref ID J:105478)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Neurobiology Research
Neurotransmitter Receptor and Synaptic Vesicle Defects

Rab3atm1Sud related

Cancer Research
Oncogenes

Neurobiology Research
Neurotransmitter Receptor and Synaptic Vesicle Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Rab3atm1Sud
Allele Name targeted mutation 1, Thomas C Sudhof
Allele Type Targeted (knock-out)
Common Name(s) Rab3a-;
Mutation Made ByDr. Thomas Sudhof,   Stanford University School of Medicine
Strain of Origin129
ES Cell Line Strain129
Gene Symbol and Name Rab3a, RAB3A, member RAS oncogene family
Chromosome 8
Gene Common Name(s) RAB3;
Molecular Note A neomycin cassette replaced the promoter and the first two exons of the gene. Western blots of brain extracts did not detect any encoded protein in homozygous mice. [MGI Ref ID J:64297]
 
Allele Symbol Rab3btm1Sud
Allele Name targeted mutation 1, Thomas C Sudhof
Allele Type Targeted (knock-out)
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14.1
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name Rab3b, RAB3B, member RAS oncogene family
Chromosome 4
Gene Common Name(s) 2610528C18Rik; RIKEN cDNA 2610528C18 gene;
Molecular Note A targeting vector was designed to replace exon 1, encoding residues 1-76, with a neomycin resistance cassette. Absence of protein was confirmed in immunoblot analysis of mutant brain samples. [MGI Ref ID J:105478]
 
Allele Symbol Rab3ctm1Sud
Allele Name targeted mutation 1, Thomas C Sudhof
Allele Type Targeted (knock-out)
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14.1
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name Rab3c, RAB3C, member RAS oncogene family
Chromosome 13
Gene Common Name(s) 2700062I01Rik; 3110015B08Rik; 3110037E15Rik; AI850886; RIKEN cDNA 2700062I01 gene; RIKEN cDNA 3110015B08 gene; RIKEN cDNA 3110037E15 gene; expressed sequence AI850886;
Molecular Note A targeting vector was designed to replace exon 1, encoding residues 9-84, with a neomycin resistance cassette. Absence of protein was confirmed in immunoblot analysis of mutant brain samples. [MGI Ref ID J:105478]
 
Allele Symbol Rab3dtm1Rja
Allele Name targeted mutation 1, Reinhard Jahn
Allele Type Targeted (knock-out)
Common Name(s) Rab3D-KO;
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14.1
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name Rab3d, RAB3D, member RAS oncogene family
Chromosome 9
Gene Common Name(s) C130057E11Rik; D2-2; GOV; RAB16; RAD3D; RIKEN cDNA C130057E11 gene;
Molecular Note The first exon was replaced with a neomycin resistance gene. Absence of gene protein was established by immunoblot analysis of pancreatic zymogen granules from homozygous mice. [MGI Ref ID J:84542]

Genotyping

Genotyping Information

Genotyping Protocols

Rab3btm1Sud,

Separated MCA


Rab3atm1Sud, Standard PCR
Rab3btm1Sud, Separated PCR
Rab3ctm1Sud, Standard PCR
Rab3dtm1Rja, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Schluter OM; Schmitz F; Jahn R; Rosenmund C; Sudhof TC. 2004. A complete genetic analysis of neuronal Rab3 function. J Neurosci 24(29):6629-37. [PubMed: 15269275]  [MGI Ref ID J:105478]

Additional References

Rab3atm1Sud related

Bednarek E; Caroni P. 2011. beta-Adducin is required for stable assembly of new synapses and improved memory upon environmental enrichment. Neuron 69(6):1132-46. [PubMed: 21435558]  [MGI Ref ID J:174730]

Blundell J; Kaeser PS; Sudhof TC; Powell CM. 2010. RIM1alpha and interacting proteins involved in presynaptic plasticity mediate prepulse inhibition and additional behaviors linked to schizophrenia. J Neurosci 30(15):5326-33. [PubMed: 20392954]  [MGI Ref ID J:159850]

Castillo PE; Janz R; Sudhof TC; Tzounopoulos T; Malenka RC; Nicoll RA. 1997. Rab3A is essential for mossy fibre long-term potentiation in the hippocampus. Nature 388(6642):590-3. [PubMed: 9252190]  [MGI Ref ID J:42242]

Chang B; Hawes NL; Hurd RE; Wang J; Howell D; Davisson MT; Roderick TH; Nusinowitz S; Heckenlively JR. 2005. Mouse models of ocular diseases. Vis Neurosci 22(5):587-93. [PubMed: 16332269]  [MGI Ref ID J:156373]

Coleman WL; Bill CA; Bykhovskaia M. 2007. Rab3a deletion reduces vesicle docking and transmitter release at the mouse diaphragm synapse. Neuroscience 148(1):1-6. [PubMed: 17640821]  [MGI Ref ID J:128286]

Coleman WL; Bykhovskaia M. 2010. Cooperative regulation of neurotransmitter release by Rab3a and synapsin II. Mol Cell Neurosci 44(2):190-200. [PubMed: 20338242]  [MGI Ref ID J:164134]

D'Adamo P; Wolfer DP; Kopp C; Tobler I; Toniolo D; Lipp HP. 2004. Mice deficient for the synaptic vesicle protein Rab3a show impaired spatial reversal learning and increased explorative activity but none of the behavioral changes shown by mice deficient for the Rab3a regulator Gdi1. Eur J Neurosci 19(7):1895-905. [PubMed: 15078563]  [MGI Ref ID J:89723]

Feliciano P; Andrade R; Bykhovskaia M. 2013. Synapsin II and Rab3a cooperate in the regulation of epileptic and synaptic activity in the CA1 region of the hippocampus. J Neurosci 33(46):18319-30. [PubMed: 24227741]  [MGI Ref ID J:204165]

Geppert M; Bolshakov VY; Siegelbaum SA; Takei K; De Camilli P; Hammer RE; Sudhof TC. 1994. The role of Rab3A in neurotransmitter release. Nature 369(6480):493-7. [PubMed: 7911226]  [MGI Ref ID J:64297]

Geppert M; Goda Y; Stevens CF; Sudhof TC. 1997. The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion. Nature 387(6635):810-4. [PubMed: 9194562]  [MGI Ref ID J:111167]

Giardino L; Armelloni S; Corbelli A; Mattinzoli D; Zennaro C; Guerrot D; Tourrel F; Ikehata M; Li M; Berra S; Carraro M; Messa P; Rastaldi MP. 2009. Podocyte glutamatergic signaling contributes to the function of the glomerular filtration barrier. J Am Soc Nephrol 20(9):1929-40. [PubMed: 19578006]  [MGI Ref ID J:166334]

Gogolla N; Galimberti I; Deguchi Y; Caroni P. 2009. Wnt signaling mediates experience-related regulation of synapse numbers and mossy fiber connectivities in the adult hippocampus. Neuron 62(4):510-25. [PubMed: 19477153]  [MGI Ref ID J:157356]

Hensbroek RA; Kamal A; Baars AM; Verhage M; Spruijt BM. 2003. Spatial, contextual and working memory are not affected by the absence of mossy fiber long-term potentiation and depression. Behav Brain Res 138(2):215-23. [PubMed: 12527452]  [MGI Ref ID J:96225]

Hirsh JK; Searl TJ; Silinsky EM. 2002. Regulation by Rab3A of an endogenous modulator of neurotransmitter release at mouse motor nerve endings. J Physiol 545(Pt 2):337-43. [PubMed: 12456815]  [MGI Ref ID J:105966]

Kapfhamer D; Bettinger JC; Davies AG; Eastman CL; Smail EA; Heberlein U; McIntire SL. 2008. Loss of RAB-3/A in Caenorhabditis elegans and the mouse affects behavioral response to ethanol. Genes Brain Behav 7(6):669-76. [PubMed: 18397381]  [MGI Ref ID J:151156]

Kapfhamer D; Valladares O; Sun Y; Nolan PM; Rux JJ; Arnold SE; Veasey SC; Bucan M. 2002. Mutations in Rab3a alter circadian period and homeostatic response to sleep loss in the mouse. Nat Genet 32(2):290-5. [PubMed: 12244319]  [MGI Ref ID J:79562]

Leenders AG; Lopes da Silva FH; Ghijsen WE; Verhage M. 2001. Rab3a is involved in transport of synaptic vesicles to the active zone in mouse brain nerve terminals. Mol Biol Cell 12(10):3095-102. [PubMed: 11598194]  [MGI Ref ID J:111329]

Lonart G; Janz R; Johnson KM; Sudhof TC. 1998. Mechanism of action of rab3A in mossy fiber LTP. Neuron 21(5):1141-50. [PubMed: 9856469]  [MGI Ref ID J:110768]

Powell CM; Schoch S; Monteggia L; Barrot M; Matos MF; Feldmann N; Sudhof TC; Nestler EJ. 2004. The presynaptic active zone protein RIM1alpha is critical for normal learning and memory. Neuron 42(1):143-53. [PubMed: 15066271]  [MGI Ref ID J:89753]

Ruediger S; Vittori C; Bednarek E; Genoud C; Strata P; Sacchetti B; Caroni P. 2011. Learning-related feedforward inhibitory connectivity growth required for memory precision. Nature 473(7348):514-8. [PubMed: 21532590]  [MGI Ref ID J:172603]

Schluter OM; Basu J; Sudhof TC; Rosenmund C. 2006. Rab3 superprimes synaptic vesicles for release: implications for short-term synaptic plasticity. J Neurosci 26(4):1239-46. [PubMed: 16436611]  [MGI Ref ID J:104983]

Schonn JS; van Weering JR; Mohrmann R; Schluter OM; Sudhof TC; de Wit H; Verhage M; Sorensen JB. 2010. Rab3 proteins involved in vesicle biogenesis and priming in embryonic mouse chromaffin cells. Traffic 11(11):1415-28. [PubMed: 20716109]  [MGI Ref ID J:166046]

Silinsky EM. 2004. Adenosine decreases both presynaptic calcium currents and neurotransmitter release at the mouse neuromuscular junction. J Physiol 558(Pt 2):389-401. [PubMed: 15146054]  [MGI Ref ID J:105453]

Sons MS; Plomp JJ. 2006. Rab3A deletion selectively reduces spontaneous neurotransmitter release at the mouse neuromuscular synapse. Brain Res 1089(1):126-134. [PubMed: 16631140]  [MGI Ref ID J:109669]

Thakker-Varia S; Alder J; Crozier RA; Plummer MR; Black IB. 2001. Rab3A is required for brain-derived neurotrophic factor-induced synaptic plasticity: transcriptional analysis at the population and single-cell levels. J Neurosci 21(17):6782-90. [PubMed: 11517266]  [MGI Ref ID J:123429]

Wang X; Thiagarajan R; Wang Q; Tewolde T; Rich MM; Engisch KL. 2008. Regulation of quantal shape by Rab3A: evidence for a fusion pore-dependent mechanism. J Physiol 586(16):3949-62. [PubMed: 18591190]  [MGI Ref ID J:176387]

Wang X; Wang Q; Yang S; Bucan M; Rich MM; Engisch KL. 2011. Impaired Activity-Dependent Plasticity of Quantal Amplitude at the Neuromuscular Junction of Rab3A Deletion and Rab3A Earlybird Mutant Mice. J Neurosci 31(10):3580-8. [PubMed: 21389214]  [MGI Ref ID J:170082]

Yang S; Farias M; Kapfhamer D; Tobias J; Grant G; Abel T; Bucan M. 2007. Biochemical, molecular and behavioral phenotypes of Rab3A mutations in the mouse. Genes Brain Behav 6(1):77-96. [PubMed: 16734774]  [MGI Ref ID J:132642]

Rab3btm1Sud related

Schluter OM; Basu J; Sudhof TC; Rosenmund C. 2006. Rab3 superprimes synaptic vesicles for release: implications for short-term synaptic plasticity. J Neurosci 26(4):1239-46. [PubMed: 16436611]  [MGI Ref ID J:104983]

Schonn JS; van Weering JR; Mohrmann R; Schluter OM; Sudhof TC; de Wit H; Verhage M; Sorensen JB. 2010. Rab3 proteins involved in vesicle biogenesis and priming in embryonic mouse chromaffin cells. Traffic 11(11):1415-28. [PubMed: 20716109]  [MGI Ref ID J:166046]

Tsetsenis T; Younts TJ; Chiu CQ; Kaeser PS; Castillo PE; Sudhof TC. 2011. Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning. Proc Natl Acad Sci U S A 108(34):14300-5. [PubMed: 21844341]  [MGI Ref ID J:175234]

Rab3ctm1Sud related

Schluter OM; Basu J; Sudhof TC; Rosenmund C. 2006. Rab3 superprimes synaptic vesicles for release: implications for short-term synaptic plasticity. J Neurosci 26(4):1239-46. [PubMed: 16436611]  [MGI Ref ID J:104983]

Schonn JS; van Weering JR; Mohrmann R; Schluter OM; Sudhof TC; de Wit H; Verhage M; Sorensen JB. 2010. Rab3 proteins involved in vesicle biogenesis and priming in embryonic mouse chromaffin cells. Traffic 11(11):1415-28. [PubMed: 20716109]  [MGI Ref ID J:166046]

Rab3dtm1Rja related

Pavlos NJ; Xu J; Riedel D; Yeoh JS; Teitelbaum SL; Papadimitriou JM; Jahn R; Ross FP; Zheng MH. 2005. Rab3D regulates a novel vesicular trafficking pathway that is required for osteoclastic bone resorption. Mol Cell Biol 25(12):5253-69. [PubMed: 15923639]  [MGI Ref ID J:99225]

Riedel D; Antonin W; Fernandez-Chacon R; Alvarez de Toledo G; Jo T; Geppert M; Valentijn JA; Valentijn K; Jamieson JD; Sudhof TC; Jahn R. 2002. Rab3D is not required for exocrine exocytosis but for maintenance of normally sized secretory granules. Mol Cell Biol 22(18):6487-97. [PubMed: 12192047]  [MGI Ref ID J:84542]

Schluter OM; Basu J; Sudhof TC; Rosenmund C. 2006. Rab3 superprimes synaptic vesicles for release: implications for short-term synaptic plasticity. J Neurosci 26(4):1239-46. [PubMed: 16436611]  [MGI Ref ID J:104983]

Schonn JS; van Weering JR; Mohrmann R; Schluter OM; Sudhof TC; de Wit H; Verhage M; Sorensen JB. 2010. Rab3 proteins involved in vesicle biogenesis and priming in embryonic mouse chromaffin cells. Traffic 11(11):1415-28. [PubMed: 20716109]  [MGI Ref ID J:166046]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX10

Colony Maintenance

Breeding & HusbandryThe donating investigator maintained the strain using animals heterozygous for Rab3a and Rab3b, and homozygous for Rab3c and Rab3d targeted mutations.
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $232.00Female or MaleHomozygous for Rab3btm1Sud, Heterozygous for Rab3atm1Sud, Homozygous for Rab3dtm1Sud, Homozygous for Rab3ctm1Sud  
$232.00Female or MaleHomozygous for Rab3btm1Sud, Wild-type for Rab3atm1Sud, Homozygous for Rab3dtm1Sud, Homozygous for Rab3ctm1Sud  
Price per Pair (US dollars $)Pair Genotype
$464.00Homozygous for Rab3btm1Sud, Heterozygous for Rab3atm1Sud, Homozygous for Rab3dtm1Sud, Homozygous for Rab3ctm1Sud x Homozygous for Rab3btm1Sud, Wild-type for Rab3atm1Sud, Homozygous for Rab3dtm1Sud, Homozygous for Rab3ctm1Sud  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $301.60Female or MaleHomozygous for Rab3btm1Sud, Heterozygous for Rab3atm1Sud, Homozygous for Rab3dtm1Sud, Homozygous for Rab3ctm1Sud  
$301.60Female or MaleHomozygous for Rab3btm1Sud, Wild-type for Rab3atm1Sud, Homozygous for Rab3dtm1Sud, Homozygous for Rab3ctm1Sud  
Price per Pair (US dollars $)Pair Genotype
$603.20Homozygous for Rab3btm1Sud, Heterozygous for Rab3atm1Sud, Homozygous for Rab3dtm1Sud, Homozygous for Rab3ctm1Sud x Homozygous for Rab3btm1Sud, Wild-type for Rab3atm1Sud, Homozygous for Rab3dtm1Sud, Homozygous for Rab3ctm1Sud  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

Control Information

  Control
   100903 B6129PF2/J (approximate)
   000664 C57BL/6J (approximate)
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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