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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Type Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Background Strain C3HeB/FeJ Donor Strain SWR/J H2 Haplotype k Generation N8F5p Appearance
agouti
Related Genotype: A/ADescription
Mice homozygous for the dominant a allele exhibit an taster (avoidance as low as <.001mM concentration) phenotype to the bitter compound sucrose octaacetate. This strain may be useful in studies related to the mechanisms of taste.Development
This congenic was created in the laboratory of Dr. Glayde Whitney at Florida State University in 1994 by introgressing the SWR/J "taster" allele into the C3HeB/FeJ "demitaster" background for at least 12 generations. Mice were tested for avoidance of (a allele) or indifference to (c allele) a 0.1 mM sodium octaacetate (SOA) solution. The colony was maintained by backcrossing for additional 20 generations. In 1999, the colony was transferred to the Monell Chemical Senses Center and backcrossed for another 10 generations. After 40 generations, mice were intercrossed to generate a homozygous colony. The strain was donated to The Jackson Laboratory Repository in 2006 by Dr. Alexander Bachmanov.
Related Strains
Strains carrying Pde6brd1 allele
View Strains carrying Pde6brd1 (74 strains)
004297 B6.CXB1-Pde6brd10/J 005252 B6EiC3Sn.BLiA-Ts(1716)65Dn/DnJ 003647 B6EiC3Sn.BLiAF1 002802 C3.BLiA Pde6b+-Krd/J 001979 C3A.BLiA-Pde6b+.O20-Prph2Rd2/J 001912 C3A.BLiA-Pde6b+/J 003648 C3Sn.BLiA-Pde6b+/Dn 004766 C57BL/6J-Pde6brd1-2J/J 004828 FVB.129P2-Pde6b+ Tyrc-ch/AntJ 004808 STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
004770 SW.B6-Soab/J
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Soaa/Soaa
SWR
- taste/olfaction phenotype
- abnormal taste sensitivity (MGI Ref ID J:44684)
- mice have a higher aversion for drinking water containing calcium hydroxide than the C3HeB strain or SWR mice heterozygote for the Soaa allele
- abnormal bitter taste sensitivity (MGI Ref ID J:6574)
- mice demonstrate a strong aversion to the bitter tasting compound sucrose octaacetate (SOA) when present in drinking water at 100 micromolar concentrations compared to thirty other in-bred strains that had no aversion to SOA at this concentration
- mice avoid drinking water containing 0.1 mM of the bitter acetylated sugar sucrose octaacetate (SOA) compared to C3HeB/Fe mice that do not show any aversion to SOA at this concentration
- strong taste aversion to SOA occurs at concentrations as low as 3 micromolar while C3HeB mice only display moderate taste aversion at 1 mM
- mice also have strong taste aversions to drinking water containing 0.01 to 1 mM of brucine, strychnine, 6-n-propyl-2 thiouracil or 0.1mM denatonium benzoate while C3Heb mice do not display taste aversions at these concentrations
- mice exhibit taste aversion to quinine compounds at low concentrations (0.03 mM-0.1 mM) while control C3HeB mice only exhibit taste aversions at higher concentrations (0.3 mM-1 mM)
- aversion to water containing low concentrations of caffeine, cyclohexamide, and thiamine occurs in SWR mice while SWR mice heterozygote for the Soaa allele do not have aversion for these compounds at low concentrations
This mouse can be used to support research in many areas including:
Pde6brd1 relatedSensorineural Research
Taste Defects
Mouse/Human Gene Homologs
retinitis pigmentosa, autosomal recessive
Sensorineural Research
Retinal Degeneration
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Pde6brd1 | ||
|---|---|---|---|
| Allele Name | retinal degeneration 1 | ||
| Allele Type | Spontaneous | ||
| Common Name(s) | Pdebrd1; rd; rd-1; rd1; rodless retina; | ||
| Allele Symbol | Soaa | ||
| Allele Name | sucrose octaacetate aversion, a variant | ||
| Allele Type | Not Applicable | ||
| Common Name(s) | SOA taster; aversion; | ||
| Gene Symbol and Name | Soa, sucrose octaacetate aversion | ||
| Chromosome | 6 | ||
| General Note | Alleles in dominance order are : a allele - taster (avoidance at <1mM concentration) in SWR/J; b allele - nontaster (no avoidance) in BDP/J, C57BL/6J, C57BR/cdJ, C57L/J, SJL/J and 129/J; c allele - demitaster (avoidance near saturation) in ABP/Le, AKR/J,BALB/cByJ, BALB/cJ, C3HeB/FeJ, C3H/HeJ, DBA/2J, LP/J, NZB/BINJ, PL/J and RF/J. J:3143 | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Bachmanov AA; Li X; Li S; Neira M; Beauchamp GK; Azen EA. 2001. High-resolution genetic mapping of the sucrose octaacetate taste aversion (Soa) locus on mouse Chromosome 6. Mamm Genome 12(9):695-9. [PubMed: 11641717] [MGI Ref ID J:71412]
Boughter JD Jr; Whitney G. 1995. C3.SW-Soaa heterozygous congenic taster mice. Behav Genet 25(3):233-7. [PubMed: 7598666] [MGI Ref ID J:25226]
Additional References
Soaa relatedBoughter JD Jr; Whitney G. 1997. Behavioral specificity of the bitter taste gene Soa. Physiol Behav 63(1):101-8. [PubMed: 9402622] [MGI Ref ID J:44684]
Capeless CG; Boughter JD; Whitney G. 1994. Hydrolysis of sucrose octa-acetate: qualitative differences in taster and demistaster avoidance phenotypes. Chem Senses 19(6):595-607. [PubMed: 7735839] [MGI Ref ID J:26941]
Gannon KS; Whitney G. 1989. Sucrose octaacetate tasting in a heterogeneous population of CFW mice. Behav Genet 19(3):417-31. [PubMed: 2757593] [MGI Ref ID J:27076]
Harder DB; Capeless CG; Maggio JC; Boughter JD; Gannon KS; Whitney G; Azen EA. 1992. Intermediate sucrose octa-acetate sensitivity suggests a 3rd allele at mouse bitter taste locus Soa and Soa-Rua identity Chem Senses 17(4):391-401. [MGI Ref ID J:3143]
Harder DB; Whitney G; Frye P; Smith JC; Rashotte ME. 1984. Strain differences among mice in taste psychophysics of sucrose octaacetate Chem Senses 9:311-23. [MGI Ref ID J:14862]
Inoue M; Li X; McCaughey SA; Beauchamp GK; Bachmanov AA. 2001. Soa genotype selectively affects mouse gustatory neural responses to sucrose octaacetate. Physiol Genomics 5(4):181-6. [PubMed: 11328963] [MGI Ref ID J:70047]
Lush IE. 1981. The genetics of tasting in mice. I. Sucrose octaacetate. Genet Res 38(1):93-5. [PubMed: 7274665] [MGI Ref ID J:6574]
Shingai T; Beidler LM. 1985. Interstrain differences in bitter taste responses in mice Chem Senses 10:51-55. [MGI Ref ID J:14863]
Warren RP; Lewis RC. 1970. Taste polymorphism in mice involving a bitter sugar derivative. Nature 227(253):77-8. [PubMed: 5422630] [MGI Ref ID J:5162]
Whitney G; Harder DB. 1986. Single-locus control of sucrose octaacetate tasting among mice. Behav Genet 16(5):559-74. [PubMed: 3778411] [MGI Ref ID J:28888]
Whitney G; Harder DB; Gannon KS. 1989. The B6.SW bilineal congenic sucrose octaacetate (SOA)-taster mice. Behav Genet 19(3):409-16. [PubMed: 2757592] [MGI Ref ID J:27077]
Whitney G; Harder DB; Gannon KS; Maggio JC. 1991. Congenic lines differing in ability to taste sucrose octaacetate. In: Chemical Senses. Marcel Dekker, Inc., New York. [MGI Ref ID J:28897]
Whitney G; Maggio JC; Harder DB. 1990. Manifestations of the major gene influencing sucrose octaacetate (SOA) tasting among mice: classic taste qualitites. In: Chemical Senses. Marcel Dekker, Inc., New York. [MGI Ref ID J:28898]
Health & husbandry
Health & Colony Maintenance Information
Currently there no information available for this strain. This may be due to the supply level of this strain.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 Cryopreserved Embryos $1600.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
| Pricing for International shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 Cryopreserved Embryos $2080.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
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Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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Payment Terms and Conditions
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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