JAX Mice Database - 006435 C3HeB.SW-Soa<a>/MonJ

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Strain Name:	C3HeB.SW-Soa^a/MonJ
Stock Number:	006435
Availability:	Repository- Live

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General Terms and Conditions

Genes & Alleles

Pde6b; Pde6b^rd1; Soa; Soa^a;

Product Information

Strain Details

Type JAX^® GEMM^® Strain - Congenic

Additional information on JAX^® GEMM^® Strains.

Type JAX^® GEMM^® Strain - Mutant Strain

Mating System Homozygote x Homozygote (Female x Male)

Species laboratory mouse

Background Strain C3HeB/FeJ

Donor Strain SWR/J

H2 Haplotype k

Generation ?+F2 (05-DEC-07)

Appearance
agouti
Related Genotype: A/A
Strain Description
Mice homozygous for the dominant a allele exhibit an taster (avoidance as low as <.001mM concentration) phenotype to the bitter compound sucrose octaacetate. This strain may be useful in studies related to the mechanisms of taste.
Strain Development
This congenic was created in the laboratory of Dr. Glayde Whitney at Florida State University in 1994 by introgressing the SWR/J "taster" allele into the C3HeB/FeJ "demitaster" background for at least 12 generations. Mice were tested for avoidance of (a allele) or indifference to (c allele) a 0.1 mM sodium octaacetate (SOA) solution. The colony was maintained by backcrossing for additional 20 generations. In 1999, the colony was transferred to the Monell Chemical Senses Center and backcrossed for another 10 generations. After 40 generations, mice were intercrossed to generate a homozygous colony. The strain was donated to The Jackson Laboratory Repository in 2006 by Dr. Alexander Bachmanov.

Mammalian Phenotype Terms assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX^® Mice strain.
Soa^a/Soa^a
SWR
taste/olfaction phenotype

taste sensitivity (MGI Ref ID J:44684)

mice have a higher aversion for drinking water containing calcium hydroxide than the C3HeB strain or SWR mice heterozygote for the Soa^a allele

abnormal bitter taste sensitivity (MGI Ref ID J:6574)

mice demonstrate a strong aversion to the bitter tasting compound sucrose octaacetate (SOA) when present in drinking water at 100 micromolar concentrations compared to thirty other in-bred strains that had no aversion to SOA at this concentration

mice avoid drinking water containing 0.1 mM of the bitter acetylated sugar sucrose octaacetate (SOA) compared to C3HeB/Fe mice that do not show any aversion to SOA at this concentration

strong taste aversion to SOA occurs at concentrations as low as 3 micromolar while C3HeB mice only display moderate taste aversion at 1 mM

mice also have strong taste aversions to drinking water containing 0.01 to 1 mM of brucine, strychnine, 6-n-propyl-2 thiouracil or 0.1mM denatonium benzoate while C3Heb mice do not display taste aversions at these concentrations

mice exhibit taste aversion to quinine compounds at low concentrations (0.03 mM-0.1 mM) while control C3HeB mice only exhibit taste aversions at higher concentrations (0.3 mM-1 mM)

aversion to water containing low concentrations of caffeine, cyclohexamide, and thiamine occurs in SWR mice while SWR mice heterozygote for the Soa^a allele do not have aversion for these compounds at low concentrations

Gene & Allele Details

Allele Symbol		Pde6b^rd1
Allele Name		retinal degeneration 1
Common Name(s)		rd; rd-1; rd1; rodless retina;

Allele Symbol		Soa^a
Allele Name		sucrose octaacetate aversion, a variant
Common Name(s)		SOA taster; aversion;
Gene Symbol and Name		Soa, sucrose octaacetate aversion
Chromosome		6
General Note		Alleles in dominance order are : a allele - taster (avoidance at <1mM concentration) in SWR/J; b allele - nontaster (no avoidance) in BDP/J, C57BL/6J, C57BR/cdJ, C57L/J, SJL/J and 129/J; c allele - demitaster (avoidance near saturation) in ABP/Le, AKR/J,BALB/cByJ, BALB/cJ, C3HeB/FeJ, C3H/HeJ, DBA/2J, LP/J, NZB/BINJ, PL/J and RF/J. J:3143

Colony Maintenance

Diet Information	LabDiet® 5K52/5K67

Related Strains

Strains carrying Pde6b^rd1 allele

004202 B6.C3 Pde6b^rd1 Hps4^le/+ +-Lmx1a^dr-8J/J

000002 B6.C3-Pde6b^rd1 Hps4^le/J

001022 B6C3FeF1/J a/a

000652 BDP/J

000653 BUB/BnJ

002439 C3.129P2(B6)-B2m^tm1Unc/J

005494 C3.129S1(B6)-Grm1^rcw/J

000480 C3.MRL-Fas^lpr/J

001957 C3A Pde6b^rd1.O20/A-Prph2^Rd2/J

005973 C3Bir.129P2(B6)-Il10^C3Bir/LtJ

004326 C3Bir.129P2(B6)-Il10^tm1Cgn/Lt

003968 C3Bir.129P2(B6)-Il10^tm1Cgn/LtJ

001906 C3Ga.Cg-Cat^b/J

001904 C3H-Atcay^ji-hes/J

000659 C3H/HeJ

000784 C3H/HeJ-Fasl^gld/J

000509 C3H/HeJ-Lyst^bg-2J/J

002433 C3H/HeJ-Spnb4^qv-lnd2J/J

005972 C3H/HeJBirLtJ

001824 C3H/HeJSxJ

000635 C3H/HeOuJ

000474 C3H/HeSn

001431 C3H/HeSn-ocd/J

000661 C3H/HeSnJ

002235 C3H/HeSnJ-Ctnna2^cdf/J

002333 C3H/HeSnJ-gri/J

000658 C3HeB/FeJ

001576 C3HeB/FeJ-Atp7b^tx-J/J

002588 C3HeB/FeJ-Eya1^bor/J

001533 C3HeB/FeJ-Mc1r^E-so Gli3^Xt-J/J

001886 C3HeB/FeJLe a/a-gnd/J

001908 C3HfB/BiJ

001502 C3Sn.B6-Epha4^rb/J

001547 C3Sn.Cg-Cm/J

000656 CBA/J

000813 CBA/J-Atp7a^Mo-pew/J

000660 DA/HuSnJ

000023 FL/1ReJ

000025 FL/4ReJ

003024 FVB.129P2(B6)-Fmr1^tm1Cgr/J

002539 FVB.129P2-Abcb4^tm1Bor/J

002935 FVB.129S2(B6)-Ccnd1^tm1Wbg/J

002953 FVB.Cg-Tg(MMTVTGFA)254Rjc/J

003170 FVB.Cg-Tg(Myh6-tTA)6Smbf/J

003078 FVB.Cg-Tg(WapIgf1)39Dlr/J

003257 FVB/N-Tg(GFAPGFP)14Mes/J

002374 FVB/N-Tg(MMTV-PyVT)634Mul/J

002856 FVB/N-Tg(TIE2-lacZ)182Sato/J

002384 FVB/N-Tg(UcpDta)1Kz/J

001800 FVB/NJ

003487 FVB/NJ-Tg(XGFAP-lacZ)3Mes/J

001491 FVB/NMob

000734 MOLD/RkJ

000550 MOLF/EiJ

002423 NON/ShiLtJ

000679 P/J

000680 PL/J

100299 PLSJLF1/J

000269 SB/LeJ

005651 SJL.AK-Thy1^a/TseJ

000686 SJL/J

000688 ST/bJ

004808 STOCK Mapt^tm1(EGFP)Klt Tg(MAPT)8cPdav/J

002648 STOCK a/a Cln6^nclf/J

000279 STOCK gr +/+ Ap3d1^mh/J

005965 STOCK Tg(Pomc1-cre)16Lowl/J

004770 SW.B6-Soa^b/J

002023 SWR.M-Emv21 Emv22/J

000689 SWR/J

000939 SWR/J-Clcn1^adr-mto/J

000692 WB/ReJ Kit^W/J

100410 WBB6F1/J-Kit^W/Kit^W-v/J

000693 WC/ReJ Kitl^Sl/J

100401 WCB6F1/J Kitl^Sl Kitl^Sl-d

View Strains carrying Pde6b^rd1 (74 strains)

Strains carrying other alleles of Pde6b

004297 B6.CXB1-Pde6b^rd10/J

002802 C3.BLiA Pde6b⁺-Krd/J

001979 C3A.BLiA-Pde6b⁺.O20-Prph2^Rd2/J

001912 C3A.BLiA-Pde6b⁺/J

003648 C3Sn.BLiA-Pde6b⁺/Dn

004766 C57BL/6J-Pde6b^rd1-2J/J

004828 FVB.129P2-Pde6b⁺ Tyr^c-ch/AntJ

004808 STOCK Mapt^tm1(EGFP)Klt Tg(MAPT)8cPdav/J

View Strains carrying other alleles of Pde6b (8 strains)

Strains carrying other alleles of Soa

004770 SW.B6-Soa^b/J

View Strains carrying other alleles of Soa (1 strain)

Additional Web Information

Congenic Nomenclature

Animal Health Reports

Room Number FGB29

Research Applications

This mouse can be used to support research in many areas including:

Sensorineural Research
Taste Defects

Pde6b^rd1 related

Mouse/Human Gene Homologs
retinitis pigmentosa, autosomal recessive

Sensorineural Research
Retinal Degeneration

References

Selected Reference(s)

Bachmanov AA; Li X; Li S; Neira M; Beauchamp GK; Azen EA. 2001. High-resolution genetic mapping of the sucrose octaacetate taste aversion (Soa) locus on mouse Chromosome 6. Mamm Genome 12(9):695-9. [PubMed: 11641717] [MGI Ref ID J:71412]
Boughter JD Jr; Whitney G. 1995. C3.SW-Soaa heterozygous congenic taster mice. Behav Genet 25(3):233-7. [PubMed: 7598666] [MGI Ref ID J:25226]

Additional References

Price and Supply Information

Strain Name:	*C3HeB.SW-Soa^a/MonJ*
Stock Number:	006435

Price Details

IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.

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Supply Details

Standard Supply	Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes	Usually shipped between four and eight weeks of age. This strain is included in the Mouse Mutant Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource.
Licensing	See General Terms and Conditions below

General Terms and Conditions

View JAX^® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

Ordering and Purchasing Information

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Contact Information
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Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
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Go to JAX^® Mice Query Form

004202	B6.C3 Pde6b^rd1 Hps4^le/+ +-Lmx1a^dr-8J/J
000002	B6.C3-Pde6b^rd1 Hps4^le/J
001022	B6C3FeF1/J a/a
000652	BDP/J
000653	BUB/BnJ
002439	C3.129P2(B6)-B2m^tm1Unc/J
005494	C3.129S1(B6)-Grm1^rcw/J
000480	C3.MRL-Fas^lpr/J
001957	C3A Pde6b^rd1.O20/A-Prph2^Rd2/J
005973	C3Bir.129P2(B6)-Il10^C3Bir/LtJ
004326	C3Bir.129P2(B6)-Il10^tm1Cgn/Lt
003968	C3Bir.129P2(B6)-Il10^tm1Cgn/LtJ
001906	C3Ga.Cg-Cat^b/J
001904	C3H-Atcay^ji-hes/J
000659	C3H/HeJ
000784	C3H/HeJ-Fasl^gld/J
000509	C3H/HeJ-Lyst^bg-2J/J
002433	C3H/HeJ-Spnb4^qv-lnd2J/J
005972	C3H/HeJBirLtJ
001824	C3H/HeJSxJ
000635	C3H/HeOuJ
000474	C3H/HeSn
001431	C3H/HeSn-ocd/J
000661	C3H/HeSnJ
002235	C3H/HeSnJ-Ctnna2^cdf/J
002333	C3H/HeSnJ-gri/J
000658	C3HeB/FeJ
001576	C3HeB/FeJ-Atp7b^tx-J/J
002588	C3HeB/FeJ-Eya1^bor/J
001533	C3HeB/FeJ-Mc1r^E-so Gli3^Xt-J/J
001886	C3HeB/FeJLe a/a-gnd/J
001908	C3HfB/BiJ
001502	C3Sn.B6-Epha4^rb/J
001547	C3Sn.Cg-Cm/J
000656	CBA/J
000813	CBA/J-Atp7a^Mo-pew/J
000660	DA/HuSnJ
000023	FL/1ReJ
000025	FL/4ReJ
003024	FVB.129P2(B6)-Fmr1^tm1Cgr/J
002539	FVB.129P2-Abcb4^tm1Bor/J
002935	FVB.129S2(B6)-Ccnd1^tm1Wbg/J
002953	FVB.Cg-Tg(MMTVTGFA)254Rjc/J
003170	FVB.Cg-Tg(Myh6-tTA)6Smbf/J
003078	FVB.Cg-Tg(WapIgf1)39Dlr/J
003257	FVB/N-Tg(GFAPGFP)14Mes/J
002374	FVB/N-Tg(MMTV-PyVT)634Mul/J
002856	FVB/N-Tg(TIE2-lacZ)182Sato/J
002384	FVB/N-Tg(UcpDta)1Kz/J
001800	FVB/NJ
003487	FVB/NJ-Tg(XGFAP-lacZ)3Mes/J
001491	FVB/NMob
000734	MOLD/RkJ
000550	MOLF/EiJ
002423	NON/ShiLtJ
000679	P/J
000680	PL/J
100299	PLSJLF1/J
000269	SB/LeJ
005651	SJL.AK-Thy1^a/TseJ
000686	SJL/J
000688	ST/bJ
004808	STOCK Mapt^tm1(EGFP)Klt Tg(MAPT)8cPdav/J
002648	STOCK a/a Cln6^nclf/J
000279	STOCK gr +/+ Ap3d1^mh/J
005965	STOCK Tg(Pomc1-cre)16Lowl/J
004770	SW.B6-Soa^b/J
002023	SWR.M-Emv21 Emv22/J
000689	SWR/J
000939	SWR/J-Clcn1^adr-mto/J
000692	WB/ReJ Kit^W/J
100410	WBB6F1/J-Kit^W/Kit^W-v/J
000693	WC/ReJ Kitl^Sl/J
100401	WCB6F1/J Kitl^Sl Kitl^Sl-d

004297	B6.CXB1-Pde6b^rd10/J
002802	C3.BLiA Pde6b⁺-Krd/J
001979	C3A.BLiA-Pde6b⁺.O20-Prph2^Rd2/J
001912	C3A.BLiA-Pde6b⁺/J
003648	C3Sn.BLiA-Pde6b⁺/Dn
004766	C57BL/6J-Pde6b^rd1-2J/J
004828	FVB.129P2-Pde6b⁺ Tyr^c-ch/AntJ
004808	STOCK Mapt^tm1(EGFP)Klt Tg(MAPT)8cPdav/J

Strain Name:

C3HeB.SW-Soaa/MonJ

Stock Number:

006435

Availability:

Repository- Live

General Terms and Conditions

Product Information

Strain Details

Soaa/Soaa

Gene & Allele Details

Colony Maintenance

Related Strains

Additional Web Information

Animal Health Reports

Research Applications

References

Price and Supply Information

Price Details

*NO Shipping Destination selected!

Supply Details

General Terms and Conditions

The Jackson Laboratory's Genotype Promise

C3HeB.SW-Soa^a/MonJ

Soa^a/Soa^a