Type Coisogenic; Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Generation N1F5p
Strains carrying Tg(TcraAI4)1Dvs alleleView Strains carrying Tg(TcraAI4)1Dvs (3 strains)Strains carrying other alleles of D7Mit346View Strains carrying other alleles of D7Mit346 (1 strain)Strains carrying other alleles of Gpi1
005730 129S6.CBA(B6)-Del(1)1Brk Gpi1b/Gpi1c/BrkMdfJ 002027 129S8/SvEv-Gpi1c Hprtb-m2/J 000600 B6-Gpi1b x B6CBCa Aw-J/A-T(7;15)9H Gpi1a/J 000377 B6.C-H22c Gpi1a/(HW38)ByJ 000123 B6.C-H24c Gpi1a/(HW54)ByJ 000797 B6.CAST-Gpi1a/EiJ 006561 B6.CBy(Cg)-Gpi1a-m1J/BrkJ 006562 B6.CBy(Cg)-Gusbmps Gpi1a-m1J/BrkJ 001622 B6.Cg-Gpi1a Hbath-J 002074 B6.Cg-Gpi1a Hbbd H1b/DehJ 001317 B6.Cg-Gpi1a Thy1a Igha/J 000909 B6CBy-Gpi1a/Gpi1b/J or Gpi1a-m1/Gpi1b/J 002800 C3.Cg-Gpi1a/J 006560 CBy(Cg)-Gpi1a-m1J/BrkJ 003585 NOD.B6-(Gpi1-D7Mit346)/LtJ 006437 NOD.Cg-(Gpi1-D7Mit346)C57BL/6J Tg(TcrbAI4)1Dvs/DvsJView Strains carrying other alleles of Gpi1 (16 strains)Strains carrying other alleles of Tcra
005308 B10.Cg-H2d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ 005895 B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J 002761 B10.Cg-Tg(TcrAND)53Hed/J 003147 B10.D2-Hc1 H2d H2-T18c/nSnJ-Tg(DO11.10)10Dlo/J 003199 B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRA)B1Jg/J 002116 B6.129S2-Tcratm1Mom/J 022073 B6.Cg-Rag1tm1Mom Thy1a Tg(Tcra2C,Tcrb2C)1Dlo/J 008684 B6.Cg-Rag1tm1Mom Tyrp1B-w Tg(Tcra,Tcrb)9Rest/J 014550 B6.Cg-Thy1a Tg(TcraCWM5,TcrbCWM5)1807Wuth/J 005023 B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J 005655 B6.Cg-Tg(Tcra,Tcrb)3Ayr/J 008428 B6.Cg-Tg(Tcra,Tcrb)HRCAll/J 008429 B6.Cg-Tg(Tcra,Tcrb)HRVAll/J 008006 B6.Cg-Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr/J 004194 B6.Cg-Tg(TcraTcrb)425Cbn/J 005236 B6.Cg-Tg(TcraY1,TcrbY1)416Tev/J 002115 B6;129S2-Tcratm1Mom/J 004694 B6;D2-Tg(TcrLCMV)327Sdz/JDvsJ 002408 B6;SJL-Tg(TcrAND)53Hed/J 007848 BXSB.129P2(Cg)-Tcratm1Mjo/TheoJ 021880 BXSB.B6-Tg(TcraTcrb)1100Mjb/DcrJ 004364 C.Cg-Tcratm1Mom Tcrbtm1Mom/J 003303 C.Cg-Tg(DO11.10)10Dlo/J 002045 C.SJL-Tcrac/SlkJ 002047 C.SJL-Tcrba Tcrac/SlkJ 014639 C57BL/6-Tg(Cd4-TcraDN32D3)1Aben/J 011005 C57BL/6-Tg(H2-Kb-Tcra,-Tcrb)P25Ktk/J 006912 C57BL/6-Tg(Tcra2D2,Tcrb2D2)1Kuch/J 003831 C57BL/6-Tg(TcraTcrb)1100Mjb/J 005307 CBy.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ 005922 CBy.Cg-Thy1a Tg(TcraCl1,TcrbCl1)1Shrm/J 005694 D1Lac.Cg-Tg(Tcra,Tcrb)24Efro/J 017314 NOD-Tg(TcraTcrb)2H6Lwn/J 004444 NOD.129P2(C)-Tcratm1Mjo/DoiJ 004257 NOD.Cg-Prkdcscid Tg(TcrLCMV)327Sdz/DvsJ 009377 NOD.Cg-Rag1tm1Mom Tg(TcraBDC12-4.1)10Jos Tg(TcrbBDC12-4.1)82Gse/J 024476 NOD.Cg-Stat4tm1Gru Thy1a Ifngr1tm1Agt Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/LmbrJ 005686 NOD.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ 004696 NOD.Cg-Tg(TcrLCMV)327Sdz/DvsJ 004460 NOD.Cg-Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/DoiJ 010526 NOD.Cg-Tg(TcraTcrbNY4.1)1Pesa/DvsJ 005868 NOD.Cg-Tg(TcraTcrbNY8.3)1Pesa/DvsJ 006303 NOD.FVB-Tg(TcraBDC12-4.1)10Jos/GseJ 018030 SJL.Cg-Tg(TcraTcrbVP2)1Bkim/J 002597 STOCK Tg(TcrHEL3A9)1Mmd/JView Strains carrying other alleles of Tcra (45 strains)
Currently there is no phenotype information for this strain.
|Allele Name||transgene insertion 1, David V Serreze|
|Allele Type||Transgenic (Inserted expressed sequence)|
|Mutation Made By||Dr. David Serreze, The Jackson Laboratory|
|Strain of Origin||NOD/ShiLt|
|Expressed Gene||Tcra, T cell receptor alpha chain, mouse, laboratory|
|Promoter||Tcra, T cell receptor alpha chain, mouse, laboratory|
In conjunction with Rag1tm1Mom|
|Molecular Note||The rearranged Tcra transgene expressed in these mice is derived from the pancreatic beta cell-reactive CD8 T lymphocyte clone AI4. The transgene contains a Tcra-V8/Tcra-J cDNA segment. [MGI Ref ID J:93553]|
|Gene Symbol and Name||D7Mit346, DNA segment, Chr 7, Massachusetts Institute of Technology 346|
|Gene Symbol and Name||Gpi1, glucose phosphate isomerase 1|
|Gene Common Name(s)||AMF; GNPI; Gpi-1; Gpi-1r; Gpi-1s; Gpi-1t; Gpi1-r; Gpi1-s; Gpi1-t; MF; NK; NK/GPI; NLK; Org; PGI; PHI; SA-36; SA36; autocrine motility factor; glucose phosphate isomerase 1, regulatory; glucose phosphate isomerase 1, structural; glucose phosphate isomerase 1, temporal; maturation factor; neuroleukin;|
Chen J; Gusdon AM; Piganelli J; Leiter EH; Mathews CE. 2011. mt-Nd2(a) Modifies resistance against autoimmune type 1 diabetes in NOD mice at the level of the pancreatic beta-cell. Diabetes 60(1):355-9. [PubMed: 20980458] [MGI Ref ID J:170153]
Chen YG; Chen J; Osborne MA; Chapman HD; Besra GS; Porcelli SA; Leiter EH; Wilson SB; Serreze DV. 2006. CD38 is required for the peripheral survival of immunotolerogenic CD4+ invariant NK T cells in nonobese diabetic mice. J Immunol 177(5):2939-47. [PubMed: 16920929] [MGI Ref ID J:112615]
Chen YG; Silveira PA; Osborne MA; Chapman HD; Serreze DV. 2007. Cellular expression requirements for inhibition of type 1 diabetes by a dominantly protective major histocompatibility complex haplotype. Diabetes 56(2):424-30. [PubMed: 17259387] [MGI Ref ID J:121957]
Choisy-Rossi CM; Holl TM; Pierce MA; Chapman HD; Serreze DV. 2004. Enhanced pathogenicity of diabetogenic T cells escaping a non-MHC gene-controlled near death experience. J Immunol 173(6):3791-800. [PubMed: 15356126] [MGI Ref ID J:167508]
DiLorenzo TP; Lieberman SM; Takaki T; Honda S; Chapman HD; Santamaria P; Serreze DV; Nathenson SG. 2002. During the early prediabetic period in NOD mice, the pathogenic CD8(+) T-cell population comprises multiple antigenic specificities. Clin Immunol 105(3):332-41. [PubMed: 12498815] [MGI Ref ID J:94192]
Driver JP; Chen YG; Zhang W; Asrat S; Serreze DV. 2011. Unmasking genes in a type 1 diabetes-resistant mouse strain that enhances pathogenic CD8 T-cell responses. Diabetes 60(4):1354-9. [PubMed: 21307079] [MGI Ref ID J:171763]
Driver JP; Scheuplein F; Chen YG; Grier AE; Wilson SB; Serreze DV. 2010. Invariant natural killer T-cell control of type 1 diabetes: a dendritic cell genetic decision of a silver bullet or Russian roulette. Diabetes 59(2):423-32. [PubMed: 19903740] [MGI Ref ID J:164162]
Graser RT; DiLorenzo TP; Wang F; Christianson GJ; Chapman HD; Roopenian DC; Nathenson SG; Serreze DV. 2000. Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions. J Immunol 164(7):3913-8. [PubMed: 10725754] [MGI Ref ID J:93553]
Lee JS; Scandiuzzi L; Ray A; Wei J; Hofmeyer KA; Abadi YM; Loke P; Lin J; Yuan J; Serreze DV; Allison JP; Zang X. 2012. B7x in the periphery abrogates pancreas-specific damage mediated by self-reactive CD8 T cells. J Immunol 189(8):4165-74. [PubMed: 22972920] [MGI Ref ID J:190522]
Leiter EH; Reifsnyder P; Driver J; Kamdar S; Choisy-Rossi C; Serreze DV; Hara M; Chervonsky A. 2007. Unexpected functional consequences of xenogeneic transgene expression in beta-cells of NOD mice. Diabetes Obes Metab 9 Suppl 2:14-22. [PubMed: 17919174] [MGI Ref ID J:127015]
Mukherjee G; Geliebter A; Babad J; Santamaria P; Serreze DV; Freeman GJ; Tarbell KV; Sharpe A; Dilorenzo TP. 2013. DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8+ T cells independently of PD-1 and PD-L1. Int Immunol 25(11):651-60. [PubMed: 24021877] [MGI Ref ID J:202027]
Pang S; Zhang L; Wang H; Yi Z; Li L; Gao L; Zhao J; Tisch R; Katz JD; Wang B. 2009. CD8(+) T cells specific for beta cells encounter their cognate antigens in the islets of NOD mice. Eur J Immunol 39(10):2716-24. [PubMed: 19658094] [MGI Ref ID J:153282]
Samanta D; Mukherjee G; Ramagopal UA; Chaparro RJ; Nathenson SG; DiLorenzo TP; Almo SC. 2011. Structural and functional characterization of a single-chain peptide-MHC molecule that modulates both naive and activated CD8+ T cells. Proc Natl Acad Sci U S A 108(33):13682-7. [PubMed: 21825122] [MGI Ref ID J:175993]
Serreze DV; Choisy-Rossi CM; Grier AE; Holl TM; Chapman HD; Gahagan JR; Osborne MA; Zhang W; King BL; Brown A; Roopenian D; Marron MP. 2008. Through Regulation of TCR Expression Levels, an Idd7 Region Gene(s) Interactively Contributes to the Impaired Thymic Deletion of Autoreactive Diabetogenic CD8+ T Cells in Nonobese Diabetic Mice. J Immunol 180(5):3250-9. [PubMed: 18292549] [MGI Ref ID J:131557]
Stolp J; Chen YG; Cox SL; Henck V; Zhang W; Tsaih SW; Chapman H; Stearns T; Serreze DV; Silveira PA. 2012. Subcongenic analyses reveal complex interactions between distal chromosome 4 genes controlling diabetogenic B cells and CD4 T cells in nonobese diabetic mice. J Immunol 189(3):1406-17. [PubMed: 22732593] [MGI Ref ID J:189784]
Thayer TC; Delano M; Liu C; Chen J; Padgett LE; Tse HM; Annamali M; Piganelli JD; Moldawer LL; Mathews CE. 2011. Superoxide production by macrophages and T cells is critical for the induction of autoreactivity and type 1 diabetes. Diabetes 60(8):2144-51. [PubMed: 21715554] [MGI Ref ID J:186804]
Tsui H; Chan Y; Tang L; Winer S; Cheung RK; Paltser G; Selvanantham T; Elford AR; Ellis JR; Becker DJ; Ohashi PS; Dosch HM. 2008. Targeting of pancreatic glia in type 1 diabetes. Diabetes 57(4):918-28. [PubMed: 18198358] [MGI Ref ID J:135214]
Animal Health ReportsProduction of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.
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Cryopreserved Mice - Ready for Recovery
Price (US dollars $) Cryorecovery* $2525.00
At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Cryopreserved Mice - Ready for Recovery
Price (US dollars $) Cryorecovery* $3283.00
Cryorecovery - Standard.
Progeny testing is not required.
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