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Common Names: MCK-Cre;    
These transgenic mice have the Cre recombinase gene driven by the muscle creatine kinase promoter, andCre activity is observed in skeletal and cardiac muscle. When bred with mice containing a loxP-flanked sequence of interest, Cre-mediated recombination will result in skeletal and cardiac muscle deletion of the flanked genome.


Strain Information

Type Congenic; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemNoncarrier x Hemizygote         (Female x Male)   11-DEC-12
Mating SystemHemizygote x Noncarrier         (Female x Male)   11-DEC-12
Specieslaboratory mouse
GenerationN12+N1F1 (08-MAY-15)
Generation Definitions
Donating Investigator C. Ronald Kahn,   Joslin Diabetes Center

Hemizygous mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. These transgenic mice have the Cre recombinase gene driven by the muscle creatine kinase (MCK or Ckm) promoter. Cre activity is observed in skeletal and cardiac muscle. When bred with mice containing a loxP-flanked sequence of interest, Cre-mediated recombination will result in skeletal and cardiac muscle deletion of the flanked genome.

A transgene was designed with a cre recombinase cDNA sequence (with a SV-40 large T antigen nuclear localization signal and poly(A) signal) inserted in place of the translation initiation site of the Ckm gene. This construct was injected into fertilized FVB embryos which were then implanted into CD1 foster mothers. Chimeric mice were bred to FVB inbred animals to establish transgenic offspring (founder line 5). At some point, mice were bred to insulin receptor mutant mice on a mixed B6;129S4 genetic background. The donating investigator reported that double mutants were backcrossed for 10 generations to C57BL/6 mice (see SNP note below) and then selected for the transgene (and against the targeted mutation) prior to arrival at The Jackson Laboratory.

A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, at least 1 of 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to The Jackson Laboratory Repository were on a mixed C57BL/6J ; C57BL/6N genetic background.

Control Information

   000664 C57BL/6J
  Considerations for Choosing Controls

Related Strains

Strains carrying   Tg(Ckmm-cre)5Khn allele
006405   FVB-Tg(Ckmm-cre)5Khn/J
View Strains carrying   Tg(Ckmm-cre)5Khn     (1 strain)

View Strains carrying other alleles of Ckm     (11 strains)

Strains carrying other alleles of cre
004337   129(Cg)-Foxg1tm1(cre)Skm/J
008569   129-Alpltm1(cre)Nagy/J
005989   129;FVB-Tg(PTH-cre)4167Slib/J
007179   129S.Cg-Tg(UBC-cre/ERT2)1Ejb/J
007915   129S.FVB-Tg(Amh-cre)8815Reb/J
003328   129S/Sv-Tg(Prm-cre)58Og/J
026200   129S1.Cg-Tg(Vsx2-cre)2690Chow/J
004302   129S1/Sv-Hprttm1(cre)Mnn/J
022137   129S4.Cg-Tg(Wnt1-cre)2Sor/J
003960   129S6-Tg(Prnp-GFP/cre)1Blw/J
008523   129S6.Cg-Tg(NPHS2-cre)295Lbh/BroJ
009587   B6(129S4)-Et(icre)1402Rdav/J
009588   B6(129S4)-Et(icre)1470Rdav/J
009589   B6(129S4)-Et(icre)1555Rdav/J
009586   B6(129S4)-Et(icre)754Rdav/J
012687   B6(129S4)-Tg(SYN1-icre/mRFP1)9934Rdav/J
010774   B6(Cg)-Calb2tm1(cre)Zjh/J
017562   B6(Cg)-Cd8atm1.1(cre)Koni/J
012704   B6(Cg)-Crhtm1(cre)Zjh/J
018448   B6(Cg)-Foxn1tm3(cre)Nrm/J
026801   B6(Cg)-Ins1tm1.1(cre)Thor/J
016223   B6(Cg)-Tg(Phox2b-cre)3Jke/J
016959   B6.129(Cg)-Foxp3tm4(YFP/cre)Ayr/J
023055   B6.129(Cg)-Krt12tm3(cre)Wwk/J
008320   B6.129-Leprtm2(cre)Rck/J
017526   B6.129-Nos1tm1(cre)Mgmj/J
005697   B6.129-Otx1tm4(cre)Asim/J
018938   B6.129-Tac2tm1.1(cre)Qima/J
017769   B6.129-Trpv1tm1(cre)Bbm/J
004146   B6.129-Tg(Pcp2-cre)2Mpin/J
008710   B6.129P2(129S4)-Hprttm10(Ple162-EGFP/cre)Ems/Mmjax
008877   B6.129P2(129S4)-Hprttm12(Ple177-EGFP/cre)Ems/Mmjax
009116   B6.129P2(129S4)-Hprttm16(Ple167-EGFP/cre)Ems/Mmjax
008709   B6.129P2(129S4)-Hprttm9(Ple178-EGFP/cre)Ems/Mmjax
006785   B6.129P2(C)-Cd19tm1(cre)Cgn/J
006084   B6.129P2(Cg)-Foxg1tm1(cre)Skm/J
010611   B6.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
007770   B6.129P2-Aicdatm1(cre)Mnz/J
004781   B6.129P2-Lyz2tm1(cre)Ifo/J
017320   B6.129P2-Pvalbtm1(cre)Arbr/J
017915   B6.129S(Cg)-Pgrtm1.1(cre)Shah/AndJ
013594   B6.129S-Atoh1tm5.1(Cre/PGR)Hzo/J
021794   B6.129S1(Cg)-Ascl3tm1.1(EGFP/cre)Ovi/J
024637   B6.129S1(SJL)-Nkx2-5tm2(cre)Rph/J
006600   B6.129S1-Mnx1tm4(cre)Tmj/J
005628   B6.129S2-Emx1tm1(cre)Krj/J
022510   B6.129S4-Gpr88tm1.1(cre/GFP)Rpa/J
017578   B6.129S4-Mcpt8tm1(cre)Lky/J
003755   B6.129S4-Meox2tm1(cre)Sor/J
007893   B6.129S4-Myf5tm3(cre)Sor/J
006878   B6.129S6-Taglntm2(cre)Yec/J
012839   B6.129X1(Cg)-Tnfrsf4tm2(cre)Nik/J
008712   B6.129X1-Twist2tm1.1(cre)Dor/J
006054   B6.C-Tg(CMV-cre)1Cgn/J
020811   B6.C-Tg(Pgk1-cre)1Lni/CrsJ
023530   B6.Cg-Avptm1.1(cre)Hze/J
013590   B6.Cg-Braftm1Mmcm Ptentm1Hwu Tg(Tyr-cre/ERT2)13Bos/BosJ
006230   B6.Cg-Cebpatm1Dgt Tg(Mx1-cre)1Cgn/J
012358   B6.Cg-Pvalbtm1.1(cre)Aibs/J
005622   B6.Cg-Shhtm1(EGFP/cre)Cjt/J
022762   B6.Cg-Zfp335tm1.2Caw Emx1tm1(cre)Krj/J
017346   B6.Cg-Tg(A930038C07Rik-cre)1Aibs/J
006149   B6.Cg-Tg(ACTA1-cre)79Jme/J
003574   B6.Cg-Tg(Alb-cre)21Mgn/J
006881   B6.Cg-Tg(Aqp2-cre)1Dek/J
011104   B6.Cg-Tg(Atoh1-cre)1Bfri/J
008520   B6.Cg-Tg(CD2-cre)4Kio/J
009350   B6.Cg-Tg(CDX2-cre)101Erf/J
009352   B6.Cg-Tg(CDX2-cre*)189Erf/J
027310   B6.Cg-Tg(Camk2a-cre)2Szi/J
027400   B6.Cg-Tg(Camk2a-cre)3Szi/J
005359   B6.Cg-Tg(Camk2a-cre)T29-1Stl/J
022071   B6.Cg-Tg(Cd4-cre)1Cwi/BfluJ
012237   B6.Cg-Tg(Cdh16-cre)91Igr/J
006368   B6.Cg-Tg(Cr2-cre)3Cgn/J
006663   B6.Cg-Tg(Eno2-cre)39Jme/J
005069   B6.Cg-Tg(Fabp4-cre)1Rev/J
012712   B6.Cg-Tg(Fev-cre)1Esd/J
012849   B6.Cg-Tg(GFAP-cre/ERT2)505Fmv/J
012886   B6.Cg-Tg(Gfap-cre)73.12Mvs/J
024098   B6.Cg-Tg(Gfap-cre)77.6Mvs/2J
009642   B6.Cg-Tg(Gh1-cre)1Sac/J
024474   B6.Cg-Tg(Il9-cre)#Stck/J
003573   B6.Cg-Tg(Ins2-cre)25Mgn/J
008068   B6.Cg-Tg(Itgax-cre)1-1Reiz/J
008781   B6.Cg-Tg(Kap-cre)29066/2Sig/J
003802   B6.Cg-Tg(Lck-cre)548Jxm/J
006889   B6.Cg-Tg(Lck-cre)I540Jxm/J
012837   B6.Cg-Tg(Lck-icre)3779Nik/J
009643   B6.Cg-Tg(Lhb-cre)1Sac/J
008330   B6.Cg-Tg(Mc4r-cre)25Rck/J
003556   B6.Cg-Tg(Mx1-cre)1Cgn/J
007742   B6.Cg-Tg(Myh11-cre,-EGFP)2Mik/J
008205   B6.Cg-Tg(NPHS2-cre)295Lbh/J
003771   B6.Cg-Tg(Nes-cre)1Kln/J
010536   B6.Cg-Tg(Pcp2-cre)3555Jdhu/J
005975   B6.Cg-Tg(Plp1-cre/ERT)3Pop/J
008827   B6.Cg-Tg(Prdm1-cre)1Masu/J
005584   B6.Cg-Tg(Prrx1-cre)1Cjt/J
003967   B6.Cg-Tg(Rbp3-cre)528Jxm/J
021614   B6.Cg-Tg(S100A8-cre,-EGFP)1Ilw/J
008454   B6.Cg-Tg(Sox2-cre)1Amc/J
006361   B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/J
003966   B6.Cg-Tg(Syn1-cre)671Jxm/J
017491   B6.Cg-Tg(Tagln-cre)1Her/J
004128   B6.Cg-Tg(Tek-cre)12Flv/J
008863   B6.Cg-Tg(Tek-cre)1Ywa/J
008601   B6.Cg-Tg(Th-cre)1Tmd/J
012328   B6.Cg-Tg(Tyr-cre/ERT2)13Bos/J
008085   B6.Cg-Tg(UBC-cre/ERT2)1Ejb/J
008610   B6.Cg-Tg(Vav1-cre)A2Kio/J
004586   B6.Cg-Tg(Vil-cre)997Gum/J
021504   B6.Cg-Tg(Vil1-cre)1000Gum/J
008735   B6.Cg-Tg(Wap-cre)11738Mam/JKnwJ
009614   B6.Cg-Tg(Wfs1-cre/ERT2)2Aibs/J
009107   B6.Cg-Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
022501   B6.Cg-Tg(Wnt1-cre)2Sor/J
006234   B6.Cg-Tg(tetO-cre)1Jaw/J
016832   B6.FVB(129)-Tg(Alb1-cre)1Dlr/J
005657   B6.FVB(129)-Tg(Myh6-cre/Esr1*)1Jmk/J
024688   B6.FVB(129S)-Tg(Pax6-GFP/cre)1Rilm/J
006451   B6.FVB(129X1)-Tg(Sim1-cre)1Lowl/J
006333   B6.FVB(Cg)-Tg(Neurog3-cre)C1Able/J
014643   B6.FVB-Tg(CMA1-cre)6Thhe/J
006137   B6.FVB-Tg(Cdh5-cre)7Mlia/J
018980   B6.FVB-Tg(Ddx4-cre)1Dcas/KnwJ
003724   B6.FVB-Tg(EIIa-cre)C5379Lmgd/J
011069   B6.FVB-Tg(Gh1-cre)bKnmn/J
011038   B6.FVB-Tg(Myh6-cre)2182Mds/J
014647   B6.FVB-Tg(Pdx1-cre)6Tuv/J
010714   B6.FVB-Tg(Pomc-cre)1Lowl/J
022791   B6.FVB-Tg(Rorc-cre)1Litt/J
017535   B6.FVB-Tg(Slc32a1-cre)2.1Hzo/FrkJ
017490   B6.FVB-Tg(Stra8-icre)1Reb/LguJ
024670   B6.FVB-Tg(Ucp1-cre)1Evdr/J
003394   B6.FVB-Tg(Zp3-cre)3Mrt/J
006660   B6.SJL-Slc6a3tm1.1(cre)Bkmn/J
003552   B6129-Tg(Wap-cre)11738Mam/J
023161   B6129S-Tg(Foxp3-EGFP/cre)1aJbs/J
021025   B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-cre)Haho/J
010529   B6;129-Myf5tm1(cre)Mrc/J
010528   B6;129-Myf6tm2(cre)Mrc/J
017525   B6;129-Ntstm1(cre)Mgmj/J
005549   B6;129-Pax3tm1(cre)Joe/J
017968   B6;129-Tg(Cdh5-cre)1Spe/J
024860   B6;129-Tg(Drd1-cre)120Mxu/Mmjax
010988   B6;129P-Cyp11a1tm1(GFP/cre)Pzg/J
008529   B6;129P-Tg(Neurog1-cre/ERT2)1Good/J
012601   B6;129P2-Lyve1tm1.1(EGFP/cre)Cys/J
006668   B6;129P2-Omptm4(cre)Mom/MomJ
008069   B6;129P2-Pvalbtm1(cre)Arbr/J
012373   B6;129S-Hoxb1tm1(cre)Og/J
024234   B6;129S-Oxttm1.1(cre)Dolsn/J
023526   B6;129S-Rorbtm1.1(cre)Hze/J
023527   B6;129S-Slc17a7tm1.1(cre)Hze/J
023525   B6;129S-Snap25tm2.1(cre)Hze/J
021877   B6;129S-Tac1tm1.1(cre)Hze/J
021878   B6;129S-Tac2tm1.1(cre)Hze/J
017685   B6;129S-Wisp3tm1(cre)Mawa/J
007001   B6;129S-Tg(UBC-cre/ERT2)1Ejb/J
009388   B6;129S1-Osr2tm2(cre)Jian/J
012463   B6;129S4-Foxd1tm1(GFP/cre)Amc/J
011105   B6;129S4-Olig1tm1(cre)Rth/J
006410   B6;129S6-Chattm2(cre)Lowl/J
009616   B6;C3-Tg(A930038C07Rik-cre)4Aibs/J
012433   B6;C3-Tg(ACTA1-rtTA,tetO-cre)102Monk/J
008844   B6;C3-Tg(Ctgf-cre)2Aibs/J
008839   B6;C3-Tg(Cyp39a1-cre)1Aibs/J
009117   B6;C3-Tg(Cyp39a1-cre)7Aibs/J
008848   B6;C3-Tg(Mybpc1-cre)2Aibs/J
009111   B6;C3-Tg(Scnn1a-cre)1Aibs/J
009112   B6;C3-Tg(Scnn1a-cre)2Aibs/J
009613   B6;C3-Tg(Scnn1a-cre)3Aibs/J
009103   B6;C3-Tg(Wfs1-cre/ERT2)3Aibs/J
025806   B6;CBA-Tg(Gsx2-cre)1Kess/J
026555   B6;CBA-Tg(Lhx6-cre)1Kess/J
025807   B6;CBA-Tg(Sox10-cre)1Wdr/J
024507   B6;CBA-Tg(Tbx21-cre)1Dlc/J
017494   B6;D-Tg(Tshz3-GFP/cre)43Amc/J
024926   B6;D2-Tg(Fshr-cre)1Ldu/J
003466   B6;D2-Tg(Sycp1-cre)4Min/J
014160   B6;DBA-Tg(S100b-EGFP/cre/ERT2)22Amc/J
014159   B6;DBA-Tg(Tmem100-EGFP/cre/ERT2)30Amc/J
015855   B6;DBA-Tg(Upk3a-GFP/cre/ERT2)26Amc/J
010803   B6;FVB-Tg(Adipoq-cre)1Evdr/J
018422   B6;FVB-Tg(Aicda-cre)1Rcas/J
023748   B6;FVB-Tg(Aldh1l1-cre)JD1884Gsat/J
011087   B6;FVB-Tg(Crh-cre)1Kres/J
008533   B6;FVB-Tg(Cspg4-cre)1Akik/J
003734   B6;FVB-Tg(GZMB-cre)1Jcb/J
015850   B6;SJL-Pde6b+ Tg(Rho-icre)1Ck/Boc
004426   B6;SJL-Tg(Cga-cre)3Sac/J
003554   B6;SJL-Tg(Col2a1-cre)1Bhr/J
017738   B6;SJL-Tg(Foxl1-cre)1Khk/J
005249   B6;SJL-Tg(Krt1-15-cre/PGR)22Cot/J
019893   B6;SJL-Tg(Tex101-icre)2Lzj/J
007252   B6Ei.129S4-Tg(Prm-cre)58Og/EiJ
025524   B6J.B6N(Cg)-Cx3cr1tm1.1(cre)Jung/J
018956   B6N.129P2(B6)-Lyz2tm1(cre)Ifo/J
018958   B6N.129P2-Cd19tm1(cre)Cgn/J
021077   B6N.129S1-Mrgprb4tm3(cre)And/J
018957   B6N.129S6(B6)-Chattm2(cre)Lowl/J
017911   B6N.129S6(Cg)-Esr1tm1.1(cre)And/J
019013   B6N.129S6(Cg)-Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
018974   B6N.B6-Tg(Nr4a1-EGFP/cre)820Khog/J
019021   B6N.Cg-Ccktm1.1(cre)Zjh/J
019022   B6N.Cg-Gad2tm2(cre)Zjh/J
018973   B6N.Cg-Ssttm2.1(cre)Zjh/J
018961   B6N.Cg-Tg(Alb-cre)21Mgn/J
018966   B6N.Cg-Tg(Camk2a-cre)T29-1Stl/J
018965   B6N.Cg-Tg(Fabp4-cre)1Rev/J
017310   B6N.Cg-Tg(Hsd17b1-icre/ERT2)3Casa/J
018960   B6N.Cg-Tg(Ins2-cre)25Mgn/J
018967   B6N.Cg-Tg(Itgax-cre)1-1Reiz/J
018964   B6N.Cg-Tg(KRT14-cre)1Amc/J
019103   B6N.Cg-Tg(Nes-cre)1Kln/CjDswJ
014094   B6N.Cg-Tg(Sox2-cre)1Amc/J
018968   B6N.Cg-Tg(Vav1-cre)A2Kio/J
018963   B6N.Cg-Tg(Vil-cre)997Gum/J
018972   B6N.FVB(B6)-Tg(Myh6-cre)2182Mds/J
019099   B6N.FVB-Tg(ACTB-cre)2Mrt/CjDswJ
019509   B6N.FVB-Tg(BGLAP-cre)1Clem/J
023047   B6N.FVB-Tg(Dmp1-cre)1Jqfe/BwdJ
017927   B6N.FVB-Tg(Mpz-cre)26Mes/J
003465   BALB/c-Tg(CMV-cre)1Cgn/J
012641   BALB/c-Tg(S100a4-cre)1Egn/YunkJ
010612   C.129P2(Cg)-Ighg1tm1(IRES-cre)Cgn/J
017353   C.129S4(B6)-Il13tm1(YFP/cre)Lky/J
017582   C.129S4(B6)-Mcpt8tm1(cre)Lky/J
004126   C.Cg-Cd19tm1(cre)Cgn Ighb/J
005673   C.Cg-Tg(Mx1-cre)1Cgn/J
006244   C.Cg-Tg(tetO-cre)1Jaw/J
009155   C57BL/6-Cldn6tm1(cre)Dkwu/J
017557   C57BL/6-Tg(BEST1-cre)1Jdun/J
027406   C57BL/6-Tg(CD2-cre)1Lov/J
016097   C57BL/6-Tg(Car1-cre)5Flt/J
011086   C57BL/6-Tg(Cck-cre)CKres/J
008766   C57BL/6-Tg(Cd8a-cre)1Itan/J
026828   C57BL/6-Tg(Cpa3-cre)4Glli/J
006474   C57BL/6-Tg(Grik4-cre)G32-4Stl/J
008314   C57BL/6-Tg(HBB-cre)12Kpe/J
008870   C57BL/6-Tg(Hspa2-cre)1Eddy/J
016261   C57BL/6-Tg(Nes-cre/ERT2)KEisc/J
012906   C57BL/6-Tg(Nes-cre/Esr1*)1Kuan/J
027205   C57BL/6-Tg(Nms-icre)20Ywa/J
016617   C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog/J
020287   C57BL/6-Tg(Pbsn-cre/Esr1*)14Abch/J
013148   C57BL/6-Tg(Pdgfra-cre)1Clc/J
008535   C57BL/6-Tg(Pf4-cre)Q3Rsko/J
024034   C57BL/6-Tg(Pmch-cre)1Rck/J
016583   C57BL/6-Tg(Slc6a3-icre/ERT2)2Gloss/J
006888   C57BL/6-Tg(Zp3-cre)1Gwh/J
003651   C57BL/6-Tg(Zp3-cre)93Knw/J
021119   C57BL/6J-Tg(Dlx2-cre,-mCherry)4Grsr/GrsrJ
021423   C57BL/6J-Tg(Dlx2-cre,-mCherry)9Grsr/GrsrJ
007567   C57BL/6J-Tg(Itgax-cre,-EGFP)4097Ach/J
018895   C57BL/6J-Tg(Krt6,-cre,-Cerulean)1Grsr/Grsr
018896   C57BL/6J-Tg(Krt6,-cre,-Cerulean)2Grsr/Grsr
018898   C57BL/6J-Tg(Krt6,-cre,-Cerulean)4Grsr/Grsr
018899   C57BL/6J-Tg(Krt6,-cre,-Cerulean)5Grsr/Grsr
021582   C57BL/6J-Tg(Mchr1-cre)1Emf/J
008661   C57BL/6J-Tg(Nkx2-1-cre)2Sand/J
022883   C57BL/6J-Tg(Six6-cre)3Grsr/GrsrJ
022887   C57BL/6J-Tg(Six6-cre)7Grsr/GrsrJ
018754   C57BL/6J-Tg(Tbx22,-cre,-mCherry)1Grsr/GrsrJ
019363   C57BL/6J-Tg(Trp63,-cre,-Cerulean)10Grsr/Grsr
018792   C57BL/6J-Tg(Trp63,-cre,-Cerulean)4Grsr/GrsrJ
003650   C57BL/6J-Tg(Zp3-cre)82Knw/KnwJ
018151   C57BL/6N-Krt17tm1(cre,Cerulean)Murr/GrsrJ
023014   C57BL/6N-Tg(Calcrl,cre)4688Nkza/J
012686   C57BL/6N-Tg(Ppp1r2-cre)4127Nkza/J
016582   C57BL/6N-Tg(Slc32a1-icre/ERT2)3Gloss/J
026861   D2.129P2(B6)-Lyz2tm1(cre)Ifo/SjJ
026858   D2.129S4(B6)-Meox2tm1(cre)Sor/SjJ
026266   D2.B6-Tg(Zp3-cre)93Knw/SjJ
026852   D2.Cg-Tg(Gfap-cre)73.12Mvs/SjJ
024701   D2.Cg-Tg(Plp1-cre/ERT)3Pop/SjJ
026859   D2.Cg-Tg(Sox2-cre)1Amc/SjJ
026857   D2.FVB-Tg(GFAP-cre)25Mes/SjJ
026860   D2.FVB-Tg(Tek-cre)2352Rwng/SjJ
016833   FVB(Cg)-Tg(Alb1-cre)1Dlr/J
012929   FVB(Cg)-Tg(Dhh-cre)1Mejr/J
011034   FVB(Cg)-Tg(Ghrhr-cre)3242Lsk/J
021024   FVB-Tg(Csf1r-icre)1Jwp/J
006954   FVB-Tg(Ddx4-cre)1Dcas/J
004600   FVB-Tg(GFAP-cre)25Mes/J
011037   FVB-Tg(Myh6-cre)2182Mds/J
006364   FVB-Tg(Nr5a1-cre)2Lowl/J
008537   FVB-Tg(Tek-cre)2352Rwng/J
019382   FVB.Cg-Myh9tm1.1Gac Tg(NPHS2-cre)295Lbh/Mmjax
014140   FVB.Cg-Myod1tm2.1(icre)Glh/J
006139   FVB.Cg-Tg(ACTA1-cre)79Jme/J
006297   FVB.Cg-Tg(Eno2-cre)39Jme/J
018394   FVB.Cg-Tg(KRT5-cre/ERT2)2Ipc/JeldJ
008244   FVB.Cg-Tg(tetO-cre)1Jaw/J
003376   FVB/N-Tg(ACTB-cre)2Mrt/J
024384   FVB/N-Tg(AMELX-cre)A1Kul/J
003314   FVB/N-Tg(EIIa-cre)C5379Lmgd/J
025062   FVB/N-Tg(Figla-EGFP,-icre)ZP3Dean/Mmjax
017928   FVB/N-Tg(Mpz-cre)26Mes/J
025066   FVB/N-Tg(Mylpf-cre)3Kraj/Mmjax
006143   FVB/N-Tg(Thy1-cre)1Vln/J
003377   FVB/N-Tg(Zp3-cre)3Mrt/J
023325   FVB;B6-Tg(Pbsn-cre)20Fwan/J
019096   NOD.129P2(B6)-Lyz2tm1(cre)Ifo/NadlJ
023806   NOD.129P2(Cg)-Cd19tm1(cre)Cgn/J
013233   NOD.B6-Tg(Itgax-cre,-EGFP)4097Ach/J
013234   NOD.Cg-Tg(Cd4-cre)1Cwi/2AchJ
023972   NOD.Cg-Tg(Ins2-cre/ERT)1Dam/SbwJ
023203   NOD.Cg-Tg(Itgax-cre)1-1Reiz/PesaJ
005732   NOD.Cg-Tg(Lck-cre)548Jxm/AchJ
023973   NOD.Cg-Tg(Neurog3-cre)1Dam/SbwJ
013251   NOD.FVB-Tg(EIIa-cre)C5379Lmgd/J
008694   NOD/ShiLt-Tg(Foxp3-EGFP/cre)1cJbs/J
004986   NOD/ShiLt-Tg(Ins2-cre)3Lt/LtJ
003855   NOD/ShiLt-Tg(Ins2-cre)5Lt/LtJ
004987   NOD/ShiLt-Tg(Ins2-cre)6Lt/LtJ
012899   STOCK Agrptm1(cre)Lowl/J
026229   STOCK Akap12tm1Ihg Rb1tm2Brn Tg(Pbsn-cre)4Prb/J
012706   STOCK Ccktm1.1(cre)Zjh/J
010910   STOCK Corttm1(cre)Zjh/J
007916   STOCK En1tm2(cre)Wrst/J
008464   STOCK Foxa2tm2.1(cre/Esr1*)Moon/J
010802   STOCK Gad2tm2(cre)Zjh/J
018903   STOCK Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
023407   STOCK HhatTg(TFAP2A-cre)1Will/J
008876   STOCK Hprttm11(Ple176-EGFP/cre)Ems/Mmjax
016879   STOCK Il17atm1.1(icre)Stck/J
024242   STOCK Isl1tm1(cre)Sev/J
018976   STOCK Kdrtm1(cre)Sato/J
017701   STOCK Kiss1tm1.1(cre/EGFP)Stei/J
007022   STOCK Mnx1tm4(cre)Tmj Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
004192   STOCK Mttptm2Sgy Ldlrtm1Her Apobtm2Sgy Tg(Mx1-cre)1Cgn/J
023342   STOCK Myf5tm1(cre/Esr1*)Trdo/J
024713   STOCK Myl1tm1(cre)Sjb/J
014180   STOCK Myocdtm1(cre)Jomm/J
006953   STOCK Notch1tm3(cre)Rko/J
006677   STOCK Olfr151tm28(cre)Mom/MomJ
011103   STOCK Olig2tm2(TVA,cre)Rth/J
010530   STOCK Pax7tm1(cre)Mrc/J
016963   STOCK Slc17a6tm2(cre)Lowl/J
016962   STOCK Slc32a1tm2(cre)Lowl/J
013044   STOCK Ssttm2.1(cre)Zjh/J
012719   STOCK Tgfb3tm1(cre)Vk/J
012620   STOCK Trp53tm1Brd Brca1tm1Aash Tg(LGB-cre)74Acl/J
010908   STOCK Viptm1(cre)Zjh/J
010911   STOCK Wt1tm1(EGFP/cre)Wtp/J
009615   STOCK Tg(Cartpt-cre)1Aibs/J
017336   STOCK Tg(Cd4-cre)1Cwi/BfluJ
005105   STOCK Tg(Chx10-EGFP/cre,-ALPP)2Clc/J
008852   STOCK Tg(En2-cre)22Alj/J
005938   STOCK Tg(Eno2-cre)39Jme/J
011062   STOCK Tg(Gdf9-cre)5092Coo/J
012841   STOCK Tg(Ggt1-cre)M3Egn/J
021207   STOCK Tg(Gnrh1-cre)1Dlc/J
017981   STOCK Tg(Hoxb6-cre)#Mku/J
004692   STOCK Tg(Hoxb7-cre)13Amc/J
014600   STOCK Tg(I12b-cre/ERT2,-ALPP)37Fsh/J
008122   STOCK Tg(Ins2-cre/ERT)1Dam/J
004782   STOCK Tg(KRT14-cre)1Amc/J
005107   STOCK Tg(KRT14-cre/ERT)20Efu/J
008582   STOCK Tg(Kcnc2-Cre)K128Stl/LetJ
023426   STOCK Tg(Kiss1-cre)J2-4Cfe/J
017836   STOCK Tg(LGB-cre)74Acl/J
003551   STOCK Tg(MMTV-cre)1Mam/J
003553   STOCK Tg(MMTV-cre)4Mam/J
002527   STOCK Tg(Mx1-cre)1Cgn/J
009074   STOCK Tg(Myh6-cre)1Jmk/J
005650   STOCK Tg(Myh6-cre/Esr1*)1Jmk/J
009102   STOCK Tg(Nefh-cre)12Kul/J
002858   STOCK Tg(Nes-cre)1Wme/J
002859   STOCK Tg(Nes-cre)2Wme/J
012859   STOCK Tg(Neurog1-cre)1Jejo/J
005667   STOCK Tg(Neurog3-cre)C1Able/J
008119   STOCK Tg(Neurog3-cre/Esr1*)1Dam/J
012462   STOCK Tg(Nr5a1-cre)7Lowl/J
014158   STOCK Tg(Pax4-cre)1Dam/J
024578   STOCK Tg(Pax6-GFP/cre)1Rilm/J
006207   STOCK Tg(Pcp2-cre)1Amc/J
014099   STOCK Tg(Pmch-cre)1Lowl/J
005965   STOCK Tg(Pomc1-cre)16Lowl/J
012452   STOCK Tg(Rr5-GFP/cre)1Sapc/J
006395   STOCK Tg(Sim1-cre)1Lowl/J
009606   STOCK Tg(Six2-EGFP/cre)1Amc/J
019755   STOCK Tg(Six3-cre)69Frty/GcoJ
018147   STOCK Tg(Slc17a8-icre)1Edw/SealJ
012586   STOCK Tg(Slc1a3-cre/ERT)1Nat/J
004783   STOCK Tg(Sox2-cre)1Amc/J
008208   STOCK Tg(Stra8-icre)1Reb/J
016236   STOCK Tg(TCF/Lef1-cre/ERT2)1Dje/J
004746   STOCK Tg(Tagln-cre)1Her/J
012708   STOCK Tg(Thy1-cre/ERT2,-EYFP)HGfng/PyngJ
024240   STOCK Tg(Tnnt2-cre)5Blh/JiaoJ
016584   STOCK Tg(Tph2-icre/ERT2)6Gloss/J
003829   STOCK Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
008851   STOCK Tg(Wnt1-cre/ERT)1Alj/J
018281   STOCK Tg(Wnt7a-EGFP/cre)#Bhr/Mmjax
008199   STOCK Tg(dlx6a-cre)1Mekk/J
002471   STOCK Tg(hCMV-cre)140Sau/J
023724   STOCK Tg(mI56i-cre,EGFP)1Kc/J
006224   STOCK Tg(tetO-cre)1Jaw/J
View Strains carrying other alleles of cre     (401 strains)

Additional Web Information

Introduction to Cre-lox technology


Phenotype Information

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Research Applications
This mouse can be used to support research in many areas including:

Research Tools
Cardiovascular Research
      Cre-lox System
Cre-lox System
      Cre Recombinase Expression
Diabetes and Obesity Research
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Cre-lox System

cre related

Research Tools
Cre-lox System
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Cre-lox System

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol Tg(Ckmm-cre)5Khn
Allele Name transgene insertion 5, C Ronald Kahn
Allele Type Transgenic (cre- or Flp-expressing)
Common Name(s) Ckm-cre; Ckmm-NLS-cre; Ckmm-cre; CreMck; MCK-cre; MCK-cre5; MCKCre+; Tg(Ckm-cre)5Khn; Tg(Ckmm-cre)1Khn; mckCRE;
Mutation Made By C. Ronald Kahn,   Joslin Diabetes Center
Strain of OriginFVB
Site of Expressionskeletal and cardiac muscle
Expressed Gene cre, cre recombinase, bacteriophage P1
Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence.
Promoter Ckm, creatine kinase, muscle, mouse, laboratory
Driver Note Ckm
Molecular Note A 6.5 kb genomic DNA fragment of the Ckmm gene containing the promoter and enhancer 1, untranslated exon 1, 3kb of intron 1 including the enhancer 2 region, and the first 16 bp of exon 2 drives expression of a modified cre with an SV40 large T antigen nuclear localization signal. Expression is directed to the heart and skeletal muscle. [MGI Ref ID J:51266]


Genotyping Information

Genotyping Protocols

Tg(Ckmm-cre)5Khn, MELT
Tg(Ckmm-cre)5Khn, Standard PCR

Helpful Links

Genotyping resources and troubleshooting


References provided by MGI

Selected Reference(s)

Bruning JC; Michael MD; Winnay JN; Hayashi T; Horsch D; Accili D; Goodyear LJ; Kahn CR. 1998. A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol Cell 2(5):559-69. [PubMed: 9844629]  [MGI Ref ID J:51266]

Additional References

Tg(Ckmm-cre)5Khn related

Agrawal PB; Joshi M; Savic T; Chen Z; Beggs AH. 2012. Normal myofibrillar development followed by progressive sarcomeric disruption with actin accumulations in a mouse Cfl2 knockout demonstrates requirement of cofilin-2 for muscle maintenance. Hum Mol Genet :. [PubMed: 22343409]  [MGI Ref ID J:182571]

Akimoto T; Okuhira K; Aizawa K; Wada S; Honda H; Fukubayashi T; Ushida T. 2013. Skeletal muscle adaptation in response to mechanical stress in p130cas-/- mice. Am J Physiol Cell Physiol 304(6):C541-7. [PubMed: 23325412]  [MGI Ref ID J:195063]

An CI; Dong Y; Hagiwara N. 2011. Genome-wide mapping of Sox6 binding sites in skeletal muscle reveals both direct and indirect regulation of muscle terminal differentiation by Sox6. BMC Dev Biol 11:59. [PubMed: 21985497]  [MGI Ref ID J:178848]

Andersson DC; Betzenhauser MJ; Reiken S; Meli AC; Umanskaya A; Xie W; Shiomi T; Zalk R; Lacampagne A; Marks AR. 2011. Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging. Cell Metab 14(2):196-207. [PubMed: 21803290]  [MGI Ref ID J:176731]

Andrechek ER; Hardy WR; Girgis-Gabardo AA; Perry RL; Butler R; Graham FL; Kahn RC; Rudnicki MA; Muller WJ. 2002. ErbB2 is required for muscle spindle and myoblast cell survival. Mol Cell Biol 22(13):4714-22. [PubMed: 12052879]  [MGI Ref ID J:81565]

Barton ER; Park S; James JK; Makarewich CA; Philippou A; Eletto D; Lei H; Brisson B; Ostrovsky O; Li Z; Argon Y. 2012. Deletion of muscle GRP94 impairs both muscle and body growth by inhibiting local IGF production. FASEB J 26(9):3691-702. [PubMed: 22649033]  [MGI Ref ID J:187446]

Bayascas JR; Sakamoto K; Armit L; Arthur JS; Alessi DR. 2006. Evaluation of approaches to generation of tissue-specific knock-in mice. J Biol Chem 281(39):28772-81. [PubMed: 16887794]  [MGI Ref ID J:117278]

Beedle AM; Nienaber PM; Campbell KP. 2007. Fukutin-related protein associates with the sarcolemmal dystrophin-glycoprotein complex. J Biol Chem 282(23):16713-7. [PubMed: 17452335]  [MGI Ref ID J:122734]

Beedle AM; Turner AJ; Saito Y; Lueck JD; Foltz SJ; Fortunato MJ; Nienaber PM; Campbell KP. 2012. Mouse fukutin deletion impairs dystroglycan processing and recapitulates muscular dystrophy. J Clin Invest 122(9):3330-42. [PubMed: 22922256]  [MGI Ref ID J:187144]

Bence KK; Delibegovic M; Xue B; Gorgun CZ; Hotamisligil GS; Neel BG; Kahn BB. 2006. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat Med 12(8):917-24. [PubMed: 16845389]  [MGI Ref ID J:111969]

Bongers KS; Fox DK; Ebert SM; Kunkel SD; Dyle MC; Bullard SA; Dierdorff JM; Adams CM. 2013. Skeletal muscle denervation causes skeletal muscle atrophy through a pathway that involves both Gadd45a and HDAC4. Am J Physiol Endocrinol Metab 305(7):E907-15. [PubMed: 23941879]  [MGI Ref ID J:203853]

Bonner JS; Lantier L; Hasenour CM; James FD; Bracy DP; Wasserman DH. 2013. Muscle-specific vascular endothelial growth factor deletion induces muscle capillary rarefaction creating muscle insulin resistance. Diabetes 62(2):572-80. [PubMed: 23002035]  [MGI Ref ID J:208473]

Braun TP; Szumowski M; Levasseur PR; Grossberg AJ; Zhu X; Agarwal A; Marks DL. 2014. Muscle atrophy in response to cytotoxic chemotherapy is dependent on intact glucocorticoid signaling in skeletal muscle. PLoS One 9(9):e106489. [PubMed: 25254959]  [MGI Ref ID J:222500]

Burcelin R; Crivelli V; Perrin C; Da Costa A; Mu J; Kahn BB; Birnbaum MJ; Kahn CR; Vollenweider P; Thorens B. 2003. GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor-stimulated muscle glucose utilization. J Clin Invest 111(10):1555-62. [PubMed: 12750405]  [MGI Ref ID J:134630]

Camara Y; Asin-Cayuela J; Park CB; Metodiev MD; Shi Y; Ruzzenente B; Kukat C; Habermann B; Wibom R; Hultenby K; Franz T; Erdjument-Bromage H; Tempst P; Hallberg BM; Gustafsson CM; Larsson NG. 2011. MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome. Cell Metab 13(5):527-39. [PubMed: 21531335]  [MGI Ref ID J:175816]

Cariou B; Postic C; Boudou P; Burcelin R; Kahn CR; Girard J; Burnol AF; Mauvais-Jarvis F. 2004. Cellular and molecular mechanisms of adipose tissue plasticity in muscle insulin receptor knockout mice. Endocrinology 145(4):1926-32. [PubMed: 14684612]  [MGI Ref ID J:88697]

Carvalho E; Kotani K; Peroni OD; Kahn BB. 2005. Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle. Am J Physiol Endocrinol Metab 289(4):E551-61. [PubMed: 15928024]  [MGI Ref ID J:101261]

Chen H; Zhang W; Sun X; Yoshimoto M; Chen Z; Zhu W; Liu J; Shen Y; Yong W; Li D; Zhang J; Lin Y; Li B; Vandusen NJ; Snider P; Schwartz RJ; Conway SJ; Field LJ; Yoder MC; Firulli AB; Carlesso N; Towbin JA; Shou W. 2013. Fkbp1a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch1 activity. Development 140(9):1946-57. [PubMed: 23571217]  [MGI Ref ID J:195489]

Chen T; Li Z; Zhang Y; Feng F; Wang X; Wang X; Shen QW. 2015. Muscle-selective knockout of AMPKalpha2 does not exacerbate diet-induced obesity probably related to altered myokines expression. Biochem Biophys Res Commun 458(3):449-55. [PubMed: 25637528]  [MGI Ref ID J:220329]

Chouchani ET; Methner C; Buonincontri G; Hu CH; Logan A; Sawiak SJ; Murphy MP; Krieg T. 2014. Complex I deficiency due to selective loss of Ndufs4 in the mouse heart results in severe hypertrophic cardiomyopathy. PLoS One 9(4):e94157. [PubMed: 24705922]  [MGI Ref ID J:215018]

Clark R; Mannikko R; Stuckey DJ; Iberl M; Clarke K; Ashcroft FM. 2012. Mice expressing a human K(ATP) channel mutation have altered channel ATP sensitivity but no cardiac abnormalities. Diabetologia 55(4):1195-204. [PubMed: 22252471]  [MGI Ref ID J:181882]

Clark RH; McTaggart JS; Webster R; Mannikko R; Iberl M; Sim XL; Rorsman P; Glitsch M; Beeson D; Ashcroft FM. 2010. Muscle dysfunction caused by a KATP channel mutation in neonatal diabetes is neuronal in origin. Science 329(5990):458-61. [PubMed: 20595581]  [MGI Ref ID J:162008]

Cohen SE; Kokkotou E; Biddinger SB; Kondo T; Gebhardt R; Kratzsch J; Mantzoros CS; Kahn CR. 2007. High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice. J Biol Chem 282(32):23672-8. [PubMed: 17556363]  [MGI Ref ID J:124577]

Cohn RD; Henry MD; Michele DE; Barresi R; Saito F; Moore SA; Flanagan JD; Skwarchuk MW; Robbins ME; Mendell JR; Williamson RA; Campbell KP. 2002. Disruption of DAG1 in differentiated skeletal muscle reveals a role for dystroglycan in muscle regeneration. Cell 110(5):639-48. [PubMed: 12230980]  [MGI Ref ID J:78838]

Crackower MA; Oudit GY; Kozieradzki I; Sarao R; Sun H; Sasaki T; Hirsch E; Suzuki A; Shioi T; Irie-Sasaki J; Sah R; Cheng HY; Rybin VO; Lembo G; Fratta L; Oliveira-dos-Santos AJ; Benovic JL; Kahn CR; Izumo S; Steinberg SF; Wymann MP; Backx PH; Penninger JM. 2002. Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell 110(6):737-49. [PubMed: 12297047]  [MGI Ref ID J:79151]

Delibegovic M; Bence KK; Mody N; Hong EG; Ko HJ; Kim JK; Kahn BB; Neel BG. 2007. Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B. Mol Cell Biol 27(21):7727-34. [PubMed: 17724080]  [MGI Ref ID J:129081]

Duvezin-Caubet S; Jagasia R; Wagener J; Hofmann S; Trifunovic A; Hansson A; Chomyn A; Bauer MF; Attardi G; Larsson NG; Neupert W; Reichert AS. 2006. Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology. J Biol Chem 281(49):37972-9. [PubMed: 17003040]  [MGI Ref ID J:117614]

Ealey KN; Lu S; Lau D; Archer MC. 2008. Reduced susceptibility of muscle-specific insulin receptor knockout mice to colon carcinogenesis. Am J Physiol Gastrointest Liver Physiol 294(3):G679-86. [PubMed: 18174274]  [MGI Ref ID J:132394]

Ebert SM; Dyle MC; Kunkel SD; Bullard SA; Bongers KS; Fox DK; Dierdorff JM; Foster ED; Adams CM. 2012. Stress-induced skeletal muscle Gadd45a expression reprograms myonuclei and causes muscle atrophy. J Biol Chem 287(33):27290-301. [PubMed: 22692209]  [MGI Ref ID J:206503]

Eletto D; Maganty A; Eletto D; Dersh D; Makarewich C; Biswas C; Paton JC; Paton AW; Doroudgar S; Glembotski CC; Argon Y. 2012. Limitation of individual folding resources in the ER leads to outcomes distinct from the unfolded protein response. J Cell Sci 125(Pt 20):4865-75. [PubMed: 22854046]  [MGI Ref ID J:199764]

Farese RV; Sajan MP; Yang H; Li P; Mastorides S; Gower WR Jr; Nimal S; Choi CS; Kim S; Shulman GI; Kahn CR; Braun U; Leitges M. 2007. Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes. J Clin Invest 117(8):2289-301. [PubMed: 17641777]  [MGI Ref ID J:123964]

Foretz M; Hebrard S; Leclerc J; Zarrinpashneh E; Soty M; Mithieux G; Sakamoto K; Andreelli F; Viollet B. 2010. Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. J Clin Invest 120(7):2355-69. [PubMed: 20577053]  [MGI Ref ID J:163780]

Fornaro M; Burch PM; Yang W; Zhang L; Hamilton CE; Kim JH; Neel BG; Bennett AM. 2006. SHP-2 activates signaling of the nuclear factor of activated T cells to promote skeletal muscle growth. J Cell Biol 175(1):87-97. [PubMed: 17015617]  [MGI Ref ID J:114499]

Fox DK; Ebert SM; Bongers KS; Dyle MC; Bullard SA; Dierdorff JM; Kunkel SD; Adams CM. 2014. p53 and ATF4 mediate distinct and additive pathways to skeletal muscle atrophy during limb immobilization. Am J Physiol Endocrinol Metab 307(3):E245-61. [PubMed: 24895282]  [MGI Ref ID J:215331]

Frost RJ; Olson EN. 2011. Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs. Proc Natl Acad Sci U S A 108(52):21075-80. [PubMed: 22160727]  [MGI Ref ID J:180138]

Gao Y; Katyal S; Lee Y; Zhao J; Rehg JE; Russell HR; McKinnon PJ. 2011. DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair. Nature 471(7337):240-4. [PubMed: 21390131]  [MGI Ref ID J:170077]

Genetic Resource Science at The Jackson Laboratory. 2013. Expression/Specificity Patterns of Cre Alleles, 2013 Direct Data Submission from Genetic Resource Science :.  [MGI Ref ID J:193672]

Gilson H; Schakman O; Combaret L; Lause P; Grobet L; Attaix D; Ketelslegers JM; Thissen JP. 2007. Myostatin gene deletion prevents glucocorticoid-induced muscle atrophy. Endocrinology 148(1):452-60. [PubMed: 17038559]  [MGI Ref ID J:129558]

Gilson H; Schakman O; Kalista S; Lause P; Tsuchida K; Thissen JP. 2009. Follistatin induces muscle hypertrophy through satellite cell proliferation and inhibition of both myostatin and activin. Am J Physiol Endocrinol Metab 297(1):E157-64. [PubMed: 19435857]  [MGI Ref ID J:151164]

Goransson O; McBride A; Hawley SA; Ross FA; Shpiro N; Foretz M; Viollet B; Hardie DG; Sakamoto K. 2007. Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. J Biol Chem 282(45):32549-60. [PubMed: 17855357]  [MGI Ref ID J:126943]

Gorman JL; Liu ST; Slopack D; Shariati K; Hasanee A; Olenich S; Olfert IM; Haas TL. 2014. Angiotensin II evokes angiogenic signals within skeletal muscle through co-ordinated effects on skeletal myocytes and endothelial cells. PLoS One 9(1):e85537. [PubMed: 24416421]  [MGI Ref ID J:211942]

Gotthardt M; Hammer RE; Hubner N; Monti J; Witt CC; McNabb M; Richardson JA; Granzier H; Labeit S; Herz J. 2003. Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure. J Biol Chem 278(8):6059-65. [PubMed: 12464612]  [MGI Ref ID J:81993]

Grobet L; Pirottin D; Farnir F; Poncelet D; Royo LJ; Brouwers B; Christians E; Desmecht D; Coignoul F; Kahn R; Georges M. 2003. Modulating skeletal muscle mass by postnatal, muscle-specific inactivation of the myostatin gene. Genesis 35(4):227-38. [PubMed: 12717734]  [MGI Ref ID J:83122]

Habets DD; Coumans WA; El Hasnaoui M; Zarrinpashneh E; Bertrand L; Viollet B; Kiens B; Jensen TE; Richter EA; Bonen A; Glatz JF; Luiken JJ. 2009. Crucial role for LKB1 to AMPKalpha2 axis in the regulation of CD36-mediated long-chain fatty acid uptake into cardiomyocytes. Biochim Biophys Acta 1791(3):212-9. [PubMed: 19159696]  [MGI Ref ID J:148739]

Haemmerle G; Moustafa T; Woelkart G; Buttner S; Schmidt A; van de Weijer T; Hesselink M; Jaeger D; Kienesberger PC; Zierler K; Schreiber R; Eichmann T; Kolb D; Kotzbeck P; Schweiger M; Kumari M; Eder S; Schoiswohl G; Wongsiriroj N; Pollak NM; Radner FP; Preiss-Landl K; Kolbe T; Rulicke T; Pieske B; Trauner M; Lass A; Zimmermann R; Hoefler G; Cinti S; Kershaw EE; Schrauwen P; Madeo F; Mayer B; Zechner R. 2011. ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-alpha and PGC-1. Nat Med 17(9):1076-85. [PubMed: 21857651]  [MGI Ref ID J:176252]

Han R; Kanagawa M; Yoshida-Moriguchi T; Rader EP; Ng RA; Michele DE; Muirhead DE; Kunz S; Moore SA; Iannaccone ST; Miyake K; McNeil PL; Mayer U; Oldstone MB; Faulkner JA; Campbell KP. 2009. Basal lamina strengthens cell membrane integrity via the laminin G domain-binding motif of alpha-dystroglycan. Proc Natl Acad Sci U S A 106(31):12573-9. [PubMed: 19633189]  [MGI Ref ID J:152005]

Hansson A; Hance N; Dufour E; Rantanen A; Hultenby K; Clayton DA; Wibom R; Larsson NG. 2004. A switch in metabolism precedes increased mitochondrial biogenesis in respiratory chain-deficient mouse hearts. Proc Natl Acad Sci U S A 101(9):3136-41. [PubMed: 14978272]  [MGI Ref ID J:88652]

Hara Y; Balci-Hayta B; Yoshida-Moriguchi T; Kanagawa M; Beltran-Valero de Bernabe D; Gundesli H; Willer T; Satz JS; Crawford RW; Burden SJ; Kunz S; Oldstone MB; Accardi A; Talim B; Muntoni F; Topaloglu H; Dincer P; Campbell KP. 2011. A Dystroglycan Mutation Associated with Limb-Girdle Muscular Dystrophy. N Engl J Med 364(10):939-946. [PubMed: 21388311]  [MGI Ref ID J:169291]

Hasumi H; Baba M; Hasumi Y; Huang Y; Oh H; Hughes RM; Klein ME; Takikita S; Nagashima K; Schmidt LS; Linehan WM. 2012. Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN. J Natl Cancer Inst 104(22):1750-64. [PubMed: 23150719]  [MGI Ref ID J:192024]

Hasumi Y; Baba M; Hasumi H; Huang Y; Lang M; Reindorf R; Oh HB; Sciarretta S; Nagashima K; Haines DC; Schneider MD; Adelstein RS; Schmidt LS; Sadoshima J; Marston Linehan W. 2014. Folliculin (Flcn) inactivation leads to murine cardiac hypertrophy through mTORC1 deregulation. Hum Mol Genet 23(21):5706-19. [PubMed: 24908670]  [MGI Ref ID J:214735]

Hatley ME; Tang W; Garcia MR; Finkelstein D; Millay DP; Liu N; Graff J; Galindo RL; Olson EN. 2012. A mouse model of rhabdomyosarcoma originating from the adipocyte lineage. Cancer Cell 22(4):536-46. [PubMed: 23079662]  [MGI Ref ID J:192027]

He Y; Hakvoort TB; Kohler SE; Vermeulen JL; de Waart DR; de Theije C; ten Have GA; van Eijk HM; Kunne C; Labruyere WT; Houten SM; Sokolovic M; Ruijter JM; Deutz NE; Lamers WH. 2010. Glutamine synthetase in muscle is required for glutamine production during fasting and extrahepatic ammonia detoxification. J Biol Chem 285(13):9516-24. [PubMed: 20064933]  [MGI Ref ID J:161082]

Herrmann S; Stieber J; Stockl G; Hofmann F; Ludwig A. 2007. HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice. EMBO J 26(21):4423-32. [PubMed: 17914461]  [MGI Ref ID J:139560]

Hesser BA; Henschel O; Witzemann V. 2006. Synapse disassembly and formation of new synapses in postnatal muscle upon conditional inactivation of MuSK. Mol Cell Neurosci 31(3):470-80. [PubMed: 16337809]  [MGI Ref ID J:106867]

Hevener AL; He W; Barak Y; Le J; Bandyopadhyay G; Olson P; Wilkes J; Evans RM; Olefsky J. 2003. Muscle-specific Pparg deletion causes insulin resistance. Nat Med 9(12):1491-7. [PubMed: 14625542]  [MGI Ref ID J:86773]

Hindi SM; Sato S; Choi Y; Kumar A. 2014. Distinct roles of TRAF6 at early and late stages of muscle pathology in the mdx model of Duchenne muscular dystrophy. Hum Mol Genet 23(6):1492-505. [PubMed: 24163132]  [MGI Ref ID J:206217]

Hu J; Du J; Zhang L; Price SR; Klein JD; Wang XH. 2010. XIAP reduces muscle proteolysis induced by CKD. J Am Soc Nephrol 21(7):1174-83. [PubMed: 20431038]  [MGI Ref ID J:185934]

Hu P; Zhang D; Swenson L; Chakrabarti G; Abel ED; Litwin SE. 2003. Minimally invasive aortic banding in mice: effects of altered cardiomyocyte insulin signaling during pressure overload. Am J Physiol Heart Circ Physiol 285(3):H1261-9. [PubMed: 12738623]  [MGI Ref ID J:85401]

Hu Z; Wang H; Lee IH; Du J; Mitch WE. 2009. Endogenous glucocorticoids and impaired insulin signaling are both required to stimulate muscle wasting under pathophysiological conditions in mice. J Clin Invest 119(10):3059-69. [PubMed: 19759515]  [MGI Ref ID J:154640]

Hu Z; Wang H; Lee IH; Modi S; Wang X; Du J; Mitch WE. 2010. PTEN inhibition improves muscle regeneration in mice fed a high-fat diet. Diabetes 59(6):1312-20. [PubMed: 20200318]  [MGI Ref ID J:169364]

Hui ST; Andres AM; Miller AK; Spann NJ; Potter DW; Post NM; Chen AZ; Sachithanantham S; Jung DY; Kim JK; Davis RA. 2008. Txnip balances metabolic and growth signaling via PTEN disulfide reduction. Proc Natl Acad Sci U S A 105(10):3921-6. [PubMed: 18322014]  [MGI Ref ID J:132756]

Ikeda Y; Sato K; Pimentel DR; Sam F; Shaw RJ; Dyck JR; Walsh K. 2009. Cardiac-specific deletion of LKB1 leads to hypertrophy and dysfunction. J Biol Chem 284(51):35839-49. [PubMed: 19828446]  [MGI Ref ID J:158214]

Inazuka F; Sugiyama N; Tomita M; Abe T; Shioi G; Esumi H. 2012. Muscle-specific knock-out of NUAK family SNF1-like kinase 1 (NUAK1) prevents high fat diet-induced glucose intolerance. J Biol Chem 287(20):16379-89. [PubMed: 22418434]  [MGI Ref ID J:185463]

Ipulan LA; Suzuki K; Sakamoto Y; Murashima A; Imai Y; Omori A; Nakagata N; Nishinakamura R; Valasek P; Yamada G. 2014. Nonmyocytic androgen receptor regulates the sexually dimorphic development of the embryonic bulbocavernosus muscle. Endocrinology 155(7):2467-79. [PubMed: 24742196]  [MGI Ref ID J:214255]

Iwabu M; Yamauchi T; Okada-Iwabu M; Sato K; Nakagawa T; Funata M; Yamaguchi M; Namiki S; Nakayama R; Tabata M; Ogata H; Kubota N; Takamoto I; Hayashi YK; Yamauchi N; Waki H; Fukayama M; Nishino I; Tokuyama K; Ueki K; Oike Y; Ishii S; Hirose K; Shimizu T;Touhara K; Kadowaki T. 2010. Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1. Nature 464(7293):1313-9. [PubMed: 20357764]  [MGI Ref ID J:159462]

Jaber N; Dou Z; Chen JS; Catanzaro J; Jiang YP; Ballou LM; Selinger E; Ouyang X; Lin RZ; Zhang J; Zong WX. 2012. Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function. Proc Natl Acad Sci U S A 109(6):2003-8. [PubMed: 22308354]  [MGI Ref ID J:182628]

Jeppesen J; Maarbjerg SJ; Jordy AB; Fritzen AM; Pehmoller C; Sylow L; Serup AK; Jessen N; Thorsen K; Prats C; Qvortrup K; Dyck JR; Hunter RW; Sakamoto K; Thomson DM; Schjerling P; Wojtaszewski JF; Richter EA; Kiens B. 2013. LKB1 regulates lipid oxidation during exercise independently of AMPK. Diabetes 62(5):1490-9. [PubMed: 23349504]  [MGI Ref ID J:208558]

Jessen N; Koh HJ; Folmes CD; Wagg C; Fujii N; Lofgren B; Wolf CM; Berul CI; Hirshman MF; Lopaschuk GD; Goodyear LJ. 2010. Ablation of LKB1 in the heart leads to energy deprivation and impaired cardiac function. Biochim Biophys Acta 1802(7-8):593-600. [PubMed: 20441792]  [MGI Ref ID J:165362]

Jorgensen SB; O'Neill HM; Sylow L; Honeyman J; Hewitt KA; Palanivel R; Fullerton MD; Oberg L; Balendran A; Galic S; van der Poel C; Trounce IA; Lynch GS; Schertzer JD; Steinberg GR. 2013. Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity. Diabetes 62(1):56-64. [PubMed: 22961088]  [MGI Ref ID J:208478]

Joza N; Oudit GY; Brown D; Benit P; Kassiri Z; Vahsen N; Benoit L; Patel MM; Nowikovsky K; Vassault A; Backx PH; Wada T; Kroemer G; Rustin P; Penninger JM. 2005. Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy. Mol Cell Biol 25(23):10261-72. [PubMed: 16287843]  [MGI Ref ID J:113016]

Kanagawa M; Yu CC; Ito C; Fukada S; Hozoji-Inada M; Chiyo T; Kuga A; Matsuo M; Sato K; Yamaguchi M; Ito T; Ohtsuka Y; Katanosaka Y; Miyagoe-Suzuki Y; Naruse K; Kobayashi K; Okada T; Takeda S; Toda T. 2013. Impaired viability of muscle precursor cells in muscular dystrophy with glycosylation defects and amelioration of its severe phenotype by limited gene expression. Hum Mol Genet 22(15):3003-15. [PubMed: 23562821]  [MGI Ref ID J:198535]

Kanzleiter T; Rath M; Penkov D; Puchkov D; Schulz N; Blasi F; Schurmann A. 2014. Pknox1/Prep1 regulates mitochondrial oxidative phosphorylation components in skeletal muscle. Mol Cell Biol 34(2):290-8. [PubMed: 24216763]  [MGI Ref ID J:207764]

Kim JK; Michael MD; Previs SF; Peroni OD; Mauvais-Jarvis F; Neschen S; Kahn BB; Kahn CR; Shulman GI. 2000. Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle. J Clin Invest 105(12):1791-7. [PubMed: 10862794]  [MGI Ref ID J:120531]

Kim JK; Zisman A; Fillmore JJ; Peroni OD; Kotani K; Perret P; Zong H; Dong J; Kahn CR; Kahn BB; Shulman GI. 2001. Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4. J Clin Invest 108(1):153-60. [PubMed: 11435467]  [MGI Ref ID J:110773]

Kleinridders A; Pogoda HM; Irlenbusch S; Smyth N; Koncz C; Hammerschmidt M; Bruning JC. 2009. PLRG1 is an essential regulator of cell proliferation and apoptosis during vertebrate development and tissue homeostasis. Mol Cell Biol 29(11):3173-85. [PubMed: 19307306]  [MGI Ref ID J:149153]

Knauf C; Cani PD; Perrin C; Iglesias MA; Maury JF; Bernard E; Benhamed F; Gremeaux T; Drucker DJ; Kahn CR; Girard J; Tanti JF; Delzenne NM; Postic C; Burcelin R. 2005. Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage. J Clin Invest 115(12):3554-63. [PubMed: 16322793]  [MGI Ref ID J:104705]

Kobuke K; Piccolo F; Garringer KW; Moore SA; Sweezer E; Yang B; Campbell KP. 2008. A Common Disease-Associated Missense Mutation in Alpha-Sarcoglycan Fails to Cause Muscular Dystrophy in Mice. Hum Mol Genet :. [PubMed: 18252746]  [MGI Ref ID J:130252]

Koh HJ; Arnolds DE; Fujii N; Tran TT; Rogers MJ; Jessen N; Li Y; Liew CW; Ho RC; Hirshman MF; Kulkarni RN; Kahn CR; Goodyear LJ. 2006. Skeletal Muscle-Selective Knockout of LKB1 Increases Insulin Sensitivity, Improves Glucose Homeostasis, and Decreases TRB3. Mol Cell Biol 26(22):8217-27. [PubMed: 16966378]  [MGI Ref ID J:114640]

Koh HJ; Toyoda T; Fujii N; Jung MM; Rathod A; Middelbeek RJ; Lessard SJ; Treebak JT; Tsuchihara K; Esumi H; Richter EA; Wojtaszewski JF; Hirshman MF; Goodyear LJ. 2010. Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle. Proc Natl Acad Sci U S A 107(35):15541-6. [PubMed: 20713714]  [MGI Ref ID J:163747]

Konieczny P; Fuchs P; Reipert S; Kunz WS; Zeold A; Fischer I; Paulin D; Schroder R; Wiche G. 2008. Myofiber integrity depends on desmin network targeting to Z-disks and costameres via distinct plectin isoforms. J Cell Biol 181(4):667-81. [PubMed: 18490514]  [MGI Ref ID J:137067]

Kontaridis MI; Yang W; Bence KK; Cullen D; Wang B; Bodyak N; Ke Q; Hinek A; Kang PM; Liao R; Neel BG. 2008. Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase/mitogen-activated protein kinase and RhoA signaling pathways. Circulation 117(11):1423-35. [PubMed: 18316486]  [MGI Ref ID J:148445]

Kotani K; Peroni OD; Minokoshi Y; Boss O; Kahn BB. 2004. GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization. J Clin Invest 114(11):1666-75. [PubMed: 15578099]  [MGI Ref ID J:94432]

Laustsen PG; Russell SJ; Cui L; Entingh-Pearsall A; Holzenberger M; Liao R; Kahn CR. 2007. Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function. Mol Cell Biol 27(5):1649-64. [PubMed: 17189427]  [MGI Ref ID J:118987]

Lee NK; Skinner JP; Zajac JD; MacLean HE. 2011. Ornithine decarboxylase is upregulated by the androgen receptor in skeletal muscle and regulates myoblast proliferation. Am J Physiol Endocrinol Metab 301(1):E172-9. [PubMed: 21505150]  [MGI Ref ID J:182065]

Li F; Buck D; De Winter J; Kolb J; Meng H; Birch C; Slater R; Escobar YN; Smith III JE; Yang L; Konhilas J; Lawlor MW; Ottenheijm C; Granzier HL. 2015. Nebulin deficiency in adult muscle causes sarcinere defects and muscle-type dependent changes in trophicity - novel insights in nemaline myopathy Hum Mol Genet :.  [MGI Ref ID J:221934]

Li S; Czubryt MP; McAnally J; Bassel-Duby R; Richardson JA; Wiebel FF; Nordheim A; Olson EN. 2005. Requirement for serum response factor for skeletal muscle growth and maturation revealed by tissue-specific gene deletion in mice. Proc Natl Acad Sci U S A 102(4):1082-7. [PubMed: 15647354]  [MGI Ref ID J:96122]

Li X; Bartke A; Berryman DE; Funk K; Kopchick JJ; List EO; Sun L; Miller RA. 2013. Direct and indirect effects of growth hormone receptor ablation on liver expression of xenobiotic metabolizing genes. Am J Physiol Endocrinol Metab 305(8):E942-50. [PubMed: 23941873]  [MGI Ref ID J:203856]

Lin X; Yang X; Li Q; Ma Y; Cui S; He D; Lin X; Schwartz RJ; Chang J. 2012. Protein tyrosine phosphatase-like A regulates myoblast proliferation and differentiation through MyoG and the cell cycling signaling pathway. Mol Cell Biol 32(2):297-308. [PubMed: 22106411]  [MGI Ref ID J:183657]

Loh K; Merry TL; Galic S; Wu BJ; Watt MJ; Zhang S; Zhang ZY; Neel BG; Tiganis T. 2012. T cell protein tyrosine phosphatase (TCPTP) deficiency in muscle does not alter insulin signalling and glucose homeostasis in mice. Diabetologia 55(2):468-78. [PubMed: 22124607]  [MGI Ref ID J:181775]

Long YC; Cheng Z; Copps KD; White MF. 2011. Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways. Mol Cell Biol 31(3):430-41. [PubMed: 21135130]  [MGI Ref ID J:170424]

Luo J; McMullen JR; Sobkiw CL; Zhang L; Dorfman AL; Sherwood MC; Logsdon MN; Horner JW; DePinho RA; Izumo S; Cantley LC. 2005. Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy. Mol Cell Biol 25(21):9491-502. [PubMed: 16227599]  [MGI Ref ID J:102176]

Luo J; Sobkiw CL; Hirshman MF; Logsdon MN; Li TQ; Goodyear LJ; Cantley LC. 2006. Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia. Cell Metab 3(5):355-66. [PubMed: 16679293]  [MGI Ref ID J:129646]

MacLean HE; Chiu WS; Ma C; McManus JF; Davey RA; Cameron R; Notini AJ; Zajac JD. 2008. A floxed allele of the androgen receptor gene causes hyperandrogenization in male mice. Physiol Genomics 33(1):133-7. [PubMed: 18171720]  [MGI Ref ID J:145319]

Makino N; Maeda T; Oyama J; Sasaki M; Higuchi Y; Mimori K; Shimizu T. 2011. Antioxidant therapy attenuates myocardial telomerase activity reduction in superoxide dismutase-deficient mice. J Mol Cell Cardiol 50(4):670-7. [PubMed: 21195081]  [MGI Ref ID J:171017]

Mason SD; Howlett RA; Kim MJ; Olfert IM; Hogan MC; McNulty W; Hickey RP; Wagner PD; Kahn CR; Giordano FJ; Johnson RS. 2004. Loss of skeletal muscle HIF-1alpha results in altered exercise endurance. PLoS Biol 2(10):e288. [PubMed: 15328538]  [MGI Ref ID J:97761]

Mason SD; Rundqvist H; Papandreou I; Duh R; McNulty WJ; Howlett RA; Olfert IM; Sundberg CJ; Denko NC; Poellinger L; Johnson RS. 2007. HIF-1alpha in endurance training: suppression of oxidative metabolism. Am J Physiol Regul Integr Comp Physiol 293(5):R2059-69. [PubMed: 17855495]  [MGI Ref ID J:145111]

Mauvais-Jarvis F; Virkamaki A; Michael MD; Winnay JN; Zisman A; Kulkarni RN; Kahn CR. 2000. A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes. Diabetes 49(12):2126-34. [PubMed: 11118016]  [MGI Ref ID J:66009]

McGee SL; Mustard KJ; Hardie DG; Baar K. 2008. Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase alpha1 following overload in LKB1 knockout mice. J Physiol 586(6):1731-41. [PubMed: 18202101]  [MGI Ref ID J:141208]

Metodiev MD; Lesko N; Park CB; Camara Y; Shi Y; Wibom R; Hultenby K; Gustafsson CM; Larsson NG. 2009. Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome. Cell Metab 9(4):386-97. [PubMed: 19356719]  [MGI Ref ID J:148166]

Milenkovic D; Matic S; Kuhl I; Ruzzenente B; Freyer C; Jemt E; Park CB; Falkenberg M; Larsson NG. 2013. TWINKLE is an essential mitochondrial helicase required for synthesis of nascent D-loop strands and complete mtDNA replication. Hum Mol Genet 22(10):1983-93. [PubMed: 23393161]  [MGI Ref ID J:194965]

Mora A; Davies AM; Bertrand L; Sharif I; Budas GR; Jovanovic S; Mouton V; Kahn CR; Lucocq JM; Gray GA; Jovanovic A; Alessi DR. 2003. Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia. EMBO J 22(18):4666-76. [PubMed: 12970179]  [MGI Ref ID J:85498]

Mora A; Sakamoto K; McManus EJ; Alessi DR. 2005. Role of the PDK1-PKB-GSK3 pathway in regulating glycogen synthase and glucose uptake in the heart. FEBS Lett 579(17):3632-8. [PubMed: 15961082]  [MGI Ref ID J:99781]

Mourkioti F; Kratsios P; Luedde T; Song YH; Delafontaine P; Adami R; Parente V; Bottinelli R; Pasparakis M; Rosenthal N. 2006. Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration. J Clin Invest 116(11):2945-54. [PubMed: 17080195]  [MGI Ref ID J:114678]

Mouton V; Toussaint L; Vertommen D; Gueuning MA; Maisin L; Havaux X; Sanchez-Canedo C; Bertrand L; Dequiedt F; Hemmings BA; Hue L; Rider MH. 2010. Heart 6-phosphofructo-2-kinase activation by insulin requires PKB (protein kinase B), but not SGK3 (serum- and glucocorticoid-induced protein kinase 3). Biochem J 431(2):267-75. [PubMed: 20687898]  [MGI Ref ID J:166171]

Muoio DM; Noland RC; Kovalik JP; Seiler SE; Davies MN; DeBalsi KL; Ilkayeva OR; Stevens RD; Kheterpal I; Zhang J; Covington JD; Bajpeyi S; Ravussin E; Kraus W; Koves TR; Mynatt RL. 2012. Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility. Cell Metab 15(5):764-77. [PubMed: 22560225]  [MGI Ref ID J:184778]

Murray NR; Weems J; Braun U; Leitges M; Fields AP. 2009. Protein kinase C betaII and PKCiota/lambda: collaborating partners in colon cancer promotion and progression. Cancer Res 69(2):656-62. [PubMed: 19147581]  [MGI Ref ID J:143707]

Nojiri H; Shimizu T; Funakoshi M; Yamaguchi O; Zhou H; Kawakami S; Ohta Y; Sami M; Tachibana T; Ishikawa H; Kurosawa H; Kahn RC; Otsu K; Shirasawa T. 2006. Oxidative stress causes heart failure with impaired mitochondrial respiration. J Biol Chem 281(44):33789-801. [PubMed: 16959785]  [MGI Ref ID J:117386]

Norris AW; Chen L; Fisher SJ; Szanto I; Ristow M; Jozsi AC; Hirshman MF; Rosen ED; Goodyear LJ; Gonzalez FJ; Spiegelman BM; Kahn CR. 2003. Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. J Clin Invest 112(4):608-18. [PubMed: 12925701]  [MGI Ref ID J:85125]

Norris AW; Hirshman MF; Yao J; Jessen N; Musi N; Chen L; Sivitz WI; Goodyear LJ; Kahn CR. 2008. Endogenous peroxisome proliferator-activated receptor-gamma augments fatty acid uptake in oxidative muscle. Endocrinology 149(11):5374-83. [PubMed: 18653710]  [MGI Ref ID J:145477]

O'Neill HM; Maarbjerg SJ; Crane JD; Jeppesen J; Jorgensen SB; Schertzer JD; Shyroka O; Kiens B; van Denderen BJ; Tarnopolsky MA; Kemp BE; Richter EA; Steinberg GR. 2011. AMP-activated protein kinase (AMPK) {beta}1{beta}2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise. Proc Natl Acad Sci U S A 108(38):16092-7. [PubMed: 21896769]  [MGI Ref ID J:176578]

Olfert IM; Howlett RA; Tang K; Dalton ND; Gu Y; Peterson KL; Wagner PD; Breen EC. 2009. Muscle-specific VEGF deficiency greatly reduces exercise endurance in mice. J Physiol 587(Pt 8):1755-67. [PubMed: 19237429]  [MGI Ref ID J:176543]

Olfert IM; Howlett RA; Wagner PD; Breen EC. 2010. Myocyte vascular endothelial growth factor is required for exercise-induced skeletal muscle angiogenesis. Am J Physiol Regul Integr Comp Physiol 299(4):R1059-67. [PubMed: 20686173]  [MGI Ref ID J:164399]

Ophoff J; Van Proeyen K; Callewaert F; De Gendt K; De Bock K; Vanden Bosch A; Verhoeven G; Hespel P; Vanderschueren D. 2009. Androgen signaling in myocytes contributes to the maintenance of muscle mass and fiber type regulation but not to muscle strength or fatigue. Endocrinology 150(8):3558-66. [PubMed: 19264874]  [MGI Ref ID J:158184]

Oudit GY; Kassiri Z; Zhou J; Liu QC; Liu PP; Backx PH; Dawood F; Crackower MA; Scholey JW; Penninger JM. 2008. Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress. Cardiovasc Res 78(3):505-14. [PubMed: 18281373]  [MGI Ref ID J:161904]

Pal M; Wunderlich CM; Spohn G; Bronneke HS; Schmidt-Supprian M; Wunderlich FT. 2013. Alteration of JNK-1 signaling in skeletal muscle fails to affect glucose homeostasis and obesity-associated insulin resistance in mice. PLoS One 8(1):e54247. [PubMed: 23349837]  [MGI Ref ID J:195844]

Park CB; Asin-Cayuela J; Camara Y; Shi Y; Pellegrini M; Gaspari M; Wibom R; Hultenby K; Erdjument-Bromage H; Tempst P; Falkenberg M; Gustafsson CM; Larsson NG. 2007. MTERF3 is a negative regulator of mammalian mtDNA transcription. Cell 130(2):273-85. [PubMed: 17662942]  [MGI Ref ID J:145125]

Paul PK; Bhatnagar S; Mishra V; Srivastava S; Darnay BG; Choi Y; Kumar A. 2012. The E3 ubiquitin ligase TRAF6 intercedes in starvation-induced skeletal muscle atrophy through multiple mechanisms. Mol Cell Biol 32(7):1248-59. [PubMed: 22290431]  [MGI Ref ID J:183693]

Paul PK; Gupta SK; Bhatnagar S; Panguluri SK; Darnay BG; Choi Y; Kumar A. 2010. Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice. J Cell Biol 191(7):1395-411. [PubMed: 21187332]  [MGI Ref ID J:167987]

Pelletier S; Gingras S; Howell S; Vogel P; Ihle JN. 2012. An early onset progressive motor neuron disorder in Scyl1-deficient mice is associated with mislocalization of TDP-43. J Neurosci 32(47):16560-73. [PubMed: 23175812]  [MGI Ref ID J:192445]

Philp A; Chen A; Lan D; Meyer GA; Murphy AN; Knapp AE; Olfert IM; McCurdy CE; Marcotte GR; Hogan MC; Baar K; Schenk S. 2011. Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise. J Biol Chem 286(35):30561-70. [PubMed: 21757760]  [MGI Ref ID J:176615]

Poncet N; Mitchell FE; Ibrahim AF; McGuire VA; English G; Arthur JS; Shi YB; Taylor PM. 2014. The catalytic subunit of the system L1 amino acid transporter (slc7a5) facilitates nutrient signalling in mouse skeletal muscle. PLoS One 9(2):e89547. [PubMed: 24586861]  [MGI Ref ID J:213820]

Pospisilik JA; Knauf C; Joza N; Benit P; Orthofer M; Cani PD; Ebersberger I; Nakashima T; Sarao R; Neely G; Esterbauer H; Kozlov A; Kahn CR; Kroemer G; Rustin P; Burcelin R; Penninger JM. 2007. Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell 131(3):476-91. [PubMed: 17981116]  [MGI Ref ID J:141454]

Potthoff MJ; Arnold MA; McAnally J; Richardson JA; Bassel-Duby R; Olson EN. 2007. Regulation of skeletal muscle sarcomere integrity and postnatal muscle function by Mef2c. Mol Cell Biol 27(23):8143-51. [PubMed: 17875930]  [MGI Ref ID J:129041]

Princen F; Bard E; Sheikh F; Zhang SS; Wang J; Zago WM; Wu D; Trelles RD; Bailly-Maitre B; Kahn CR; Chen Y; Reed JC; Tong GG; Mercola M; Chen J; Feng GS. 2009. Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death. Mol Cell Biol 29(2):378-88. [PubMed: 19001090]  [MGI Ref ID J:144767]

Quiat D; Voelker KA; Pei J; Grishin NV; Grange RW; Bassel-Duby R; Olson EN. 2011. Concerted regulation of myofiber-specific gene expression and muscle performance by the transcriptional repressor Sox6. Proc Natl Acad Sci U S A 108(25):10196-201. [PubMed: 21633012]  [MGI Ref ID J:173308]

Rao PK; Toyama Y; Chiang HR; Gupta S; Bauer M; Medvid R; Reinhardt F; Liao R; Krieger M; Jaenisch R; Lodish HF; Blelloch R. 2009. Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure. Circ Res 105(6):585-94. [PubMed: 19679836]  [MGI Ref ID J:161342]

Reifler A; Li X; Archambeau AJ; McDade JR; Sabha N; Michele DE; Dowling JJ. 2014. Conditional knockout of pik3c3 causes a murine muscular dystrophy. Am J Pathol 184(6):1819-30. [PubMed: 24726497]  [MGI Ref ID J:210957]

Rohl M; Pasparakis M; Baudler S; Baumgartl J; Gautam D; Huth M; De Lorenzi R; Krone W; Rajewsky K; Bruning JC. 2004. Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance. J Clin Invest 113(3):474-81. [PubMed: 14755344]  [MGI Ref ID J:87587]

Ruffell D; Mourkioti F; Gambardella A; Kirstetter P; Lopez RG; Rosenthal N; Nerlov C. 2009. A CREB-C/EBPbeta cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair. Proc Natl Acad Sci U S A 106(41):17475-80. [PubMed: 19805133]  [MGI Ref ID J:153686]

Ruzzenente B; Metodiev MD; Wredenberg A; Bratic A; Park CB; Camara Y; Milenkovic D; Zickermann V; Wibom R; Hultenby K; Erdjument-Bromage H; Tempst P; Brandt U; Stewart JB; Gustafsson CM; Larsson NG. 2012. LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs. EMBO J 31(2):443-56. [PubMed: 22045337]  [MGI Ref ID J:187800]

Sabio G; Kennedy NJ; Cavanagh-Kyros J; Jung DY; Ko HJ; Ong H; Barrett T; Kim JK; Davis RJ. 2010. Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance. Mol Cell Biol 30(1):106-15. [PubMed: 19841069]  [MGI Ref ID J:156374]

Saito F; Kanagawa M; Ikeda M; Hagiwara H; Masaki T; Ohkuma H; Katanosaka Y; Shimizu T; Sonoo M; Toda T; Matsumura K. 2014. Overexpression of LARGE suppresses muscle regeneration via down-regulation of insulin-like growth factor 1 and aggravates muscular dystrophy in mice. Hum Mol Genet 23(17):4543-58. [PubMed: 24722207]  [MGI Ref ID J:213615]

Sajan MP; Bandyopadhyay G; Miura A; Standaert ML; Nimal S; Longnus SL; Van Obberghen E; Hainault I; Foufelle F; Kahn R; Braun U; Leitges M; Farese RV. 2010. AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC. Am J Physiol Endocrinol Metab 298(2):E179-92. [PubMed: 19887597]  [MGI Ref ID J:169947]

Sajan MP; Nimal S; Mastorides S; Acevedo-Duncan M; Kahn CR; Fields AP; Braun U; Leitges M; Farese RV. 2012. Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-iota. Metabolism 61(4):459-69. [PubMed: 22225955]  [MGI Ref ID J:218585]

Sajan MP; Standaert ML; Nimal S; Varanasi U; Pastoor T; Mastorides S; Braun U; Leitges M; Farese RV. 2009. The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFkappaB in obesity. J Lipid Res 50(6):1133-45. [PubMed: 19202134]  [MGI Ref ID J:149920]

Sakamoto K; McCarthy A; Smith D; Green KA; Grahame Hardie D; Ashworth A; Alessi DR. 2005. Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction. EMBO J 24(10):1810-20. [PubMed: 15889149]  [MGI Ref ID J:98513]

Sakamoto K; Zarrinpashneh E; Budas GR; Pouleur AC; Dutta A; Prescott AR; Vanoverschelde JL; Ashworth A; Jovanovic A; Alessi DR; Bertrand L. 2006. Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1. Am J Physiol Endocrinol Metab 290(5):E780-8. [PubMed: 16332922]  [MGI Ref ID J:115768]

Scheerer N; Dehne N; Stockmann C; Swoboda S; Baba HA; Neugebauer A; Johnson RS; Fandrey J. 2013. Myeloid hypoxia-inducible factor-1alpha is essential for skeletal muscle regeneration in mice. J Immunol 191(1):407-14. [PubMed: 23729446]  [MGI Ref ID J:205360]

Shimba S; Ogawa T; Hitosugi S; Ichihashi Y; Nakadaira Y; Kobayashi M; Tezuka M; Kosuge Y; Ishige K; Ito Y; Komiyama K; Okamatsu-Ogura Y; Kimura K; Saito M. 2011. Deficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation. PLoS One 6(9):e25231. [PubMed: 21966465]  [MGI Ref ID J:177865]

Shin J; Lee SH; Kwon MC; Yang DK; Seo HR; Kim J; Kim YY; Im SK; Abel ED; Kim KT; Park WJ; Kong YY. 2013. Cardiomyocyte specific deletion of Crif1 causes mitochondrial cardiomyopathy in mice. PLoS One 8(1):e53577. [PubMed: 23308255]  [MGI Ref ID J:195714]

Shrimali RK; Weaver JA; Miller GF; Starost MF; Carlson BA; Novoselov SV; Kumaraswamy E; Gladyshev VN; Hatfield DL. 2007. Selenoprotein expression is essential in endothelial cell development and cardiac muscle function. Neuromuscul Disord 17(2):135-42. [PubMed: 17142041]  [MGI Ref ID J:129594]

Sidhu S; Gangasani A; Korotchkina LG; Suzuki G; Fallavollita JA; Canty JM Jr; Patel MS. 2008. Tissue-specific pyruvate dehydrogenase complex deficiency causes cardiac hypertrophy and sudden death of weaned male mice. Am J Physiol Heart Circ Physiol 295(3):H946-H952. [PubMed: 18586888]  [MGI Ref ID J:141289]

Srivastava M; Hsieh S; Grinberg A; Williams-Simons L; Huang SP; Pfeifer K. 2000. H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19. Genes Dev 14(10):1186-95. [PubMed: 10817754]  [MGI Ref ID J:82798]

Steiner-Champliaud MF; Schneider Y; Favre B; Paulhe F; Praetzel-Wunder S; Faulkner G; Konieczny P; Raith M; Wiche G; Adebola A; Liem RK; Langbein L; Sonnenberg A; Fontao L; Borradori L. 2010. BPAG1 isoform-b: complex distribution pattern in striated and heart muscle and association with plectin and alpha-actinin. Exp Cell Res 316(3):297-313. [PubMed: 19932097]  [MGI Ref ID J:156784]

Sterky FH; Hoffman AF; Milenkovic D; Bao B; Paganelli A; Edgar D; Wibom R; Lupica CR; Olson L; Larsson NG. 2012. Altered dopamine metabolism and increased vulnerability to MPTP in mice with partial deficiency of mitochondrial complex I in dopamine neurons. Hum Mol Genet 21(5):1078-89. [PubMed: 22090423]  [MGI Ref ID J:180604]

Sun Z; Singh N; Mullican SE; Everett LJ; Li L; Yuan L; Liu X; Epstein JA; Lazar MA. 2011. Diet-induced Lethality Due to Deletion of the Hdac3 Gene in Heart and Skeletal Muscle. J Biol Chem 286(38):33301-9. [PubMed: 21808063]  [MGI Ref ID J:176726]

Tang W; Ingalls CP; Durham WJ; Snider J; Reid MB; Wu G; Matzuk MM; Hamilton SL. 2004. Altered excitation-contraction coupling with skeletal muscle specific FKBP12 deficiency. FASEB J 18(13):1597-9. [PubMed: 15289441]  [MGI Ref ID J:94747]

Tavi P; Hansson A; Zhang SJ; Larsson NG; Westerblad H. 2005. Abnormal Ca(2+) release and catecholamine-induced arrhythmias in mitochondrial cardiomyopathy. Hum Mol Genet 14(8):1069-76. [PubMed: 15757973]  [MGI Ref ID J:97995]

Thomas MM; Wang DC; D'Souza DM; Krause MP; Layne AS; Criswell DS; O'Neill HM; Connor MK; Anderson JE; Kemp BE; Steinberg GR; Hawke TJ. 2014. Muscle-specific AMPK beta1beta2-null mice display a myopathy due to loss of capillary density in nonpostural muscles. FASEB J 28(5):2098-107. [PubMed: 24522207]  [MGI Ref ID J:212041]

Thomson DM; Brown JD; Fillmore N; Condon BM; Kim HJ; Barrow JR; Winder WW. 2007. LKB1 and the regulation of malonyl-CoA and fatty acid oxidation in muscle. Am J Physiol Endocrinol Metab 293(6):E1572-9. [PubMed: 17925454]  [MGI Ref ID J:130093]

Thomson DM; Hancock CR; Evanson BG; Kenney SG; Malan BB; Mongillo AD; Brown JD; Hepworth S; Fillmore N; Parcell AC; Kooyman DL; Winder WW. 2010. Skeletal muscle dysfunction in muscle-specific LKB1 knockout mice. J Appl Physiol 108(6):1775-85. [PubMed: 20360428]  [MGI Ref ID J:185836]

Thomson DM; Porter BB; Tall JH; Kim HJ; Barrow JR; Winder WW. 2007. Skeletal muscle and heart LKB1 deficiency causes decreased voluntary running and reduced muscle mitochondrial marker enzyme expression in mice. Am J Physiol Endocrinol Metab 292(1):E196-202. [PubMed: 16926377]  [MGI Ref ID J:116973]

Ueda S; Kitazawa S; Ishida K; Nishikawa Y; Matsui M; Matsumoto H; Aoki T; Nozaki S; Takeda T; Tamori Y; Aiba A; Kahn CR; Kataoka T; Satoh T. 2010. Crucial role of the small GTPase Rac1 in insulin-stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma. FASEB J 24(7):2254-61. [PubMed: 20203090]  [MGI Ref ID J:162357]

Vijayakumar A; Buffin NJ; Gallagher EJ; Blank J; Wu Y; Yakar S; LeRoith D. 2013. Deletion of growth hormone receptors in postnatal skeletal muscle of male mice does not alter muscle mass and response to pathological injury. Endocrinology 154(10):3776-83. [PubMed: 23861377]  [MGI Ref ID J:203293]

Vijayakumar A; Wu Y; Buffin NJ; Li X; Sun H; Gordon RE; Yakar S; LeRoith D. 2012. Skeletal muscle growth hormone receptor signaling regulates basal, but not fasting-induced, lipid oxidation. PLoS One 7(9):e44777. [PubMed: 23024761]  [MGI Ref ID J:192052]

Vijayakumar A; Wu Y; Sun H; Li X; Jeddy Z; Liu C; Schwartz GJ; Yakar S; LeRoith D. 2012. Targeted loss of GHR signaling in mouse skeletal muscle protects against high-fat diet-induced metabolic deterioration. Diabetes 61(1):94-103. [PubMed: 22187377]  [MGI Ref ID J:191513]

Wagner PD; Olfert IM; Tang K; Breen EC. 2006. Muscle-targeted deletion of VEGF and exercise capacity in mice. Respir Physiol Neurobiol 151(2-3):159-66. [PubMed: 16344007]  [MGI Ref ID J:128241]

Wan M; Easton RM; Gleason CE; Monks BR; Ueki K; Kahn CR; Birnbaum MJ. 2012. Loss of Akt1 in mice increases energy expenditure and protects against diet-induced obesity. Mol Cell Biol 32(1):96-106. [PubMed: 22037765]  [MGI Ref ID J:182721]

Wang X; Bathina M; Lynch J; Koss B; Calabrese C; Frase S; Schuetz JD; Rehg JE; Opferman JT. 2013. Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction. Genes Dev 27(12):1351-64. [PubMed: 23788622]  [MGI Ref ID J:199155]

Wang X; Blagden C; Fan J; Nowak SJ; Taniuchi I; Littman DR; Burden SJ. 2005. Runx1 prevents wasting, myofibrillar disorganization, and autophagy of skeletal muscle. Genes Dev 19(14):1715-22. [PubMed: 16024660]  [MGI Ref ID J:99622]

Wang Z; Wang B; Yang L; Guo Q; Aithmitti N; Songyang Z; Zheng H. 2009. Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis. J Neurosci 29(35):10788-801. [PubMed: 19726636]  [MGI Ref ID J:152457]

Watson ML; Baehr LM; Reichardt HM; Tuckermann JP; Bodine SC; Furlow JD. 2012. A cell-autonomous role for the glucocorticoid receptor in skeletal muscle atrophy induced by systemic glucocorticoid exposure. Am J Physiol Endocrinol Metab 302(10):E1210-20. [PubMed: 22354783]  [MGI Ref ID J:186863]

White AT; Philp A; Fridolfsson HN; Schilling JM; Murphy AN; Hamilton DL; McCurdy CE; Patel HH; Schenk S. 2014. High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression. Am J Physiol Endocrinol Metab 307(9):E764-72. [PubMed: 25159328]  [MGI Ref ID J:215559]

Wijesekara N; Konrad D; Eweida M; Jefferies C; Liadis N; Giacca A; Crackower M; Suzuki A; Mak TW; Kahn CR; Klip A; Woo M. 2005. Muscle-specific Pten deletion protects against insulin resistance and diabetes. Mol Cell Biol 25(3):1135-45. [PubMed: 15657439]  [MGI Ref ID J:95993]

Windak R; Muller J; Felley A; Akhmedov A; Wagner EF; Pedrazzini T; Sumara G; Ricci R. 2013. The AP-1 transcription factor c-Jun prevents stress-imposed maladaptive remodeling of the heart. PLoS One 8(9):e73294. [PubMed: 24039904]  [MGI Ref ID J:207557]

Wojtaszewski JF; Higaki Y; Hirshman MF; Michael MD; Dufresne SD; Kahn CR; Goodyear LJ. 1999. Exercise modulates postreceptor insulin signaling and glucose transport in muscle-specific insulin receptor knockout mice. J Clin Invest 104(9):1257-64. [PubMed: 10545524]  [MGI Ref ID J:58296]

Wu CY; Jia Z; Wang W; Ballou LM; Jiang YP; Chen B; Mathias RT; Cohen IS; Song LS; Entcheva E; Lin RZ. 2011. PI3Ks maintain the structural integrity of T-tubules in cardiac myocytes. PLoS One 6(9):e24404. [PubMed: 21912691]  [MGI Ref ID J:177701]

Xu J; Li R; Workeneh B; Dong Y; Wang X; Hu Z. 2012. Transcription factor FoxO1, the dominant mediator of muscle wasting in chronic kidney disease, is inhibited by microRNA-486. Kidney Int 82(4):401-11. [PubMed: 22475820]  [MGI Ref ID J:198180]

Xue B; Pulinilkunnil T; Murano I; Bence KK; He H; Minokoshi Y; Asakura K; Lee A; Haj F; Furukawa N; Catalano KJ; Delibegovic M; Balschi JA; Cinti S; Neel BG; Kahn BB. 2009. Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues. Mol Cell Biol 29(16):4563-73. [PubMed: 19528236]  [MGI Ref ID J:151519]

Yang Z; Hulver M; McMillan RP; Cai L; Kershaw EE; Yu L; Xue B; Shi H. 2012. Regulation of insulin and leptin signaling by muscle suppressor of cytokine signaling 3 (SOCS3). PLoS One 7(10):e47493. [PubMed: 23115649]  [MGI Ref ID J:192284]

Yechoor VK; Patti ME; Ueki K; Laustsen PG; Saccone R; Rauniyar R; Kahn CR. 2004. Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice. Proc Natl Acad Sci U S A 101(47):16525-30. [PubMed: 15546994]  [MGI Ref ID J:123452]

Zabolotny JM; Haj FG; Kim YB; Kim HJ; Shulman GI; Kim JK; Neel BG; Kahn BB. 2004. Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action. J Biol Chem 279(23):24844-51. [PubMed: 15031294]  [MGI Ref ID J:122895]

Zechner C; Lai L; Zechner JF; Geng T; Yan Z; Rumsey JW; Collia D; Chen Z; Wozniak DF; Leone TC; Kelly DP. 2010. Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivity. Cell Metab 12(6):633-42. [PubMed: 21109195]  [MGI Ref ID J:168114]

Zhang L; Pan J; Dong Y; Tweardy DJ; Dong Y; Garibotto G; Mitch WE. 2013. Stat3 activation links a C/EBPdelta to myostatin pathway to stimulate loss of muscle mass. Cell Metab 18(3):368-79. [PubMed: 24011072]  [MGI Ref ID J:203817]

Zhang P; Shan T; Liang X; Deng C; Kuang S. 2014. Mammalian target of rapamycin is essential for cardiomyocyte survival and heart development in mice. Biochem Biophys Res Commun 452(1):53-9. [PubMed: 25139234]  [MGI Ref ID J:220106]

Zhou Y; Cheng G; Dieter L; Hjalt TA; Andrade FH; Stahl JS; Kaminski HJ. 2009. An altered phenotype in a conditional knockout of Pitx2 in extraocular muscle. Invest Ophthalmol Vis Sci 50(10):4531-41. [PubMed: 19407022]  [MGI Ref ID J:154548]

Zhou Y; Gong B; Kaminski HJ. 2012. Genomic profiling reveals Pitx2 controls expression of mature extraocular muscle contraction-related genes. Invest Ophthalmol Vis Sci 53(4):1821-9. [PubMed: 22408009]  [MGI Ref ID J:196723]

Zhou Y; Liu D; Kaminski HJ. 2011. Pitx2 regulates myosin heavy chain isoform expression and multi-innervation in extraocular muscle. J Physiol 589(Pt 18):4601-14. [PubMed: 21727215]  [MGI Ref ID J:189398]

Zierler KA; Jaeger D; Pollak NM; Eder S; Rechberger GN; Radner FP; Woelkart G; Kolb D; Schmidt A; Kumari M; Preiss-Landl K; Pieske B; Mayer B; Zimmermann R; Lass A; Zechner R; Haemmerle G. 2013. Functional cardiac lipolysis in mice critically depends on comparative gene identification-58. J Biol Chem 288(14):9892-904. [PubMed: 23413028]  [MGI Ref ID J:197835]

Zisman A; Peroni OD; Abel ED; Michael MD; Mauvais-Jarvis F; Lowell BB; Wojtaszewski JF; Hirshman MF; Virkamaki A; Goodyear LJ; Kahn CR; Kahn BB. 2000. Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nat Med 6(8):924-8. [PubMed: 10932232]  [MGI Ref ID J:75418]

Zu L; Zheng X; Wang B; Parajuli N; Steenbergen C; Becker LC; Cai ZP. 2011. Ischemic Preconditioning Attenuates Mitochondrial Localization of PTEN Induced by Ischemia-Reperfusion. Am J Physiol Heart Circ Physiol :. [PubMed: 21421815]  [MGI Ref ID J:170450]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX10

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, these mice are bred as hemizygotes. While the donating investigator has not attempted to make this strain homozygous, viability of homozygous mice is expected.
Mating SystemNoncarrier x Hemizygote         (Female x Male)   11-DEC-12
Hemizygote x Noncarrier         (Female x Male)   11-DEC-12
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $239.00Female or MaleHemizygous for Tg(Ckmm-cre)5Khn  
Price per Pair (US dollars $)Pair Genotype
$313.00Hemizygous for Tg(Ckmm-cre)5Khn x Noncarrier  
$313.00Noncarrier x Hemizygous for Tg(Ckmm-cre)5Khn  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $310.70Female or MaleHemizygous for Tg(Ckmm-cre)5Khn  
Price per Pair (US dollars $)Pair Genotype
$406.90Hemizygous for Tg(Ckmm-cre)5Khn x Noncarrier  
$406.90Noncarrier x Hemizygous for Tg(Ckmm-cre)5Khn  

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

   000664 C57BL/6J
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

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In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.