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| These transgenic mice have the Cre recombinase gene driven by the muscle creatine kinase promoter, andCre activity is observed in skeletal and cardiac muscle. When bred with mice containing a loxP-flanked sequence of interest, Cre-mediated recombination will result in skeletal and cardiac muscle deletion of the flanked genome. | |||||||||||||||
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Description
Strain Information
Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Noncarrier x Hemizygote (Female x Male) 11-DEC-12 Mating System Hemizygote x Noncarrier (Female x Male) 11-DEC-12 Species laboratory mouse Generation N12+F8 (05-APR-11)
Generation DefinitionsDonating Investigator C. Ronald Kahn, Joslin Diabetes Center Description
Hemizygous mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. These transgenic mice have the Cre recombinase gene driven by the muscle creatine kinase (MCK or Ckm) promoter. Cre activity is observed in skeletal and cardiac muscle. When bred with mice containing a loxP-flanked sequence of interest, Cre-mediated recombination will result in skeletal and cardiac muscle deletion of the flanked genome.Development
A transgene was designed with a cre recombinase cDNA sequence (with a SV-40 large T antigen nuclear localization signal and poly(A) signal) inserted in place of the translation initiation site of the Ckm gene. This construct was injected into fertilized FVB embryos which were then implanted into CD1 foster mothers. Chimeric mice were bred to FVB inbred animals to establish transgenic offspring (founder line 5). At some point, mice were bred to insulin receptor mutant mice on a mixed B6;129S4 genetic background. The donating investigator reported that double mutants were backcrossed for 10 generations to C57BL/6 mice (see SNP note below) and then selected for the transgene (and against the targeted mutation) prior to arrival at The Jackson Laboratory.A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, at least 1 of 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to The Jackson Laboratory Repository were on a mixed C57BL/6J ; C57BL/6N genetic background.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Tg(Ckmm-cre)5Khn allele
006405 FVB-Tg(Ckmm-cre)5Khn/J View Strains carrying Tg(Ckmm-cre)5Khn (1 strain)
009651 B6.Cg-Sgcatm1Kcam Tg(Ckm-SGCE)1Kcam/J 014146 B6.Cg-Tg(Ckm-DYSF)3Kcam/J 012379 B6.Cg-Tg(Ckm-Ppara)HEDpk/J 006781 C57BL/6-Tg(Ckm-DGAT2)10Far/J 008231 C57BL/6-Tg(Ckm-Ppargc1a)31Brsp/J 021199 FVB-Tg(Ckm-Chrnd*S268F)1Cgz/J 019931 FVB-Tg(Ckm-Chrne*L269F)5Cgz/J 016618 FVB-Tg(Ckm-IGF1R*K1003R)1Dlr/J 008737 FVB-Tg(Ckm-Ppargc1b)T37Brsp/J
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cardiovascular Research
Cre-lox System
Cre-lox System
Cre Recombinase Expression
Diabetes and Obesity Research
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(Ckmm-cre)5Khn | ||
|---|---|---|---|
| Allele Name | transgene insertion 5, C Ronald Kahn | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | Ckm-cre; Ckmm-NLS-cre; Ckmm-cre; CreMck; MCK-cre; MCK-cre5; MCKCre+; Tg(Ckm-cre)5Khn; Tg(Ckmm-cre)1Khn; mckCRE; | ||
| Mutation Made By | C. Ronald Kahn, Joslin Diabetes Center | ||
| Strain of Origin | FVB | ||
| Site of Expression | skeletal and cardiac muscle | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Ckm, creatine kinase, muscle, mouse, laboratory | ||
| Gene Symbol and Name | Tg(Ckmm-cre)5Khn, transgene insertion 5, C Ronald Kahn | ||
| Chromosome | UN | ||
| Gene Common Name(s) | Ckmm-NLS-cre; MCK-Cre; MCK-cre5; MCKCre+; Tg(Ckmm-cre)1Khn; mckCRE; transgene insertion 1, C Ronald Kahn; | ||
| Driver Note | Ckm | ||
| Molecular Note | A 6.5 kb genomic DNA fragment of the Ckmm gene containing the promoter and enhancer 1, untranslated exon 1, 3kb of intron 1 including the enhancer 2 region, and the first 16 bp of exon 2 drives expression of a modified cre with an SV40 large T antigen nuclear localization signal. Expression is directed to the heart and skeletal muscle. [MGI Ref ID J:51266] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Tg(Ckmm-cre)5Khn, Melt Curve Analysis
Tg(Ckmm-cre)5Khn, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Bruning JC; Michael MD; Winnay JN; Hayashi T; Horsch D; Accili D; Goodyear LJ; Kahn CR. 1998. A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol Cell 2(5):559-69. [PubMed: 9844629] [MGI Ref ID J:51266]
Additional References
Tg(Ckmm-cre)5Khn relatedAgrawal PB; Joshi M; Savic T; Chen Z; Beggs AH. 2012. Normal myofibrillar development followed by progressive sarcomeric disruption with actin accumulations in a mouse Cfl2 knockout demonstrates requirement of cofilin-2 for muscle maintenance. Hum Mol Genet :. [PubMed: 22343409] [MGI Ref ID J:182571]
An CI; Dong Y; Hagiwara N. 2011. Genome-wide mapping of Sox6 binding sites in skeletal muscle reveals both direct and indirect regulation of muscle terminal differentiation by Sox6. BMC Dev Biol 11:59. [PubMed: 21985497] [MGI Ref ID J:178848]
Andersson DC; Betzenhauser MJ; Reiken S; Meli AC; Umanskaya A; Xie W; Shiomi T; Zalk R; Lacampagne A; Marks AR. 2011. Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging. Cell Metab 14(2):196-207. [PubMed: 21803290] [MGI Ref ID J:176731]
Andrechek ER; Hardy WR; Girgis-Gabardo AA; Perry RL; Butler R; Graham FL; Kahn RC; Rudnicki MA; Muller WJ. 2002. ErbB2 is required for muscle spindle and myoblast cell survival. Mol Cell Biol 22(13):4714-22. [PubMed: 12052879] [MGI Ref ID J:81565]
Barton ER; Park S; James JK; Makarewich CA; Philippou A; Eletto D; Lei H; Brisson B; Ostrovsky O; Li Z; Argon Y. 2012. Deletion of muscle GRP94 impairs both muscle and body growth by inhibiting local IGF production. FASEB J 26(9):3691-702. [PubMed: 22649033] [MGI Ref ID J:187446]
Bayascas JR; Sakamoto K; Armit L; Arthur JS; Alessi DR. 2006. Evaluation of approaches to generation of tissue-specific knock-in mice. J Biol Chem 281(39):28772-81. [PubMed: 16887794] [MGI Ref ID J:117278]
Beedle AM; Nienaber PM; Campbell KP. 2007. Fukutin-related protein associates with the sarcolemmal dystrophin-glycoprotein complex. J Biol Chem 282(23):16713-7. [PubMed: 17452335] [MGI Ref ID J:122734]
Beedle AM; Turner AJ; Saito Y; Lueck JD; Foltz SJ; Fortunato MJ; Nienaber PM; Campbell KP. 2012. Mouse fukutin deletion impairs dystroglycan processing and recapitulates muscular dystrophy. J Clin Invest 122(9):3330-42. [PubMed: 22922256] [MGI Ref ID J:187144]
Bence KK; Delibegovic M; Xue B; Gorgun CZ; Hotamisligil GS; Neel BG; Kahn BB. 2006. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat Med 12(8):917-24. [PubMed: 16845389] [MGI Ref ID J:111969]
Burcelin R; Crivelli V; Perrin C; Da Costa A; Mu J; Kahn BB; Birnbaum MJ; Kahn CR; Vollenweider P; Thorens B. 2003. GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor-stimulated muscle glucose utilization. J Clin Invest 111(10):1555-62. [PubMed: 12750405] [MGI Ref ID J:134630]
Camara Y; Asin-Cayuela J; Park CB; Metodiev MD; Shi Y; Ruzzenente B; Kukat C; Habermann B; Wibom R; Hultenby K; Franz T; Erdjument-Bromage H; Tempst P; Hallberg BM; Gustafsson CM; Larsson NG. 2011. MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome. Cell Metab 13(5):527-39. [PubMed: 21531335] [MGI Ref ID J:175816]
Cariou B; Postic C; Boudou P; Burcelin R; Kahn CR; Girard J; Burnol AF; Mauvais-Jarvis F. 2004. Cellular and molecular mechanisms of adipose tissue plasticity in muscle insulin receptor knockout mice. Endocrinology 145(4):1926-32. [PubMed: 14684612] [MGI Ref ID J:88697]
Carvalho E; Kotani K; Peroni OD; Kahn BB. 2005. Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle. Am J Physiol Endocrinol Metab 289(4):E551-61. [PubMed: 15928024] [MGI Ref ID J:101261]
Chen H; Zhang W; Sun X; Yoshimoto M; Chen Z; Zhu W; Liu J; Shen Y; Yong W; Li D; Zhang J; Lin Y; Li B; Vandusen NJ; Snider P; Schwartz RJ; Conway SJ; Field LJ; Yoder MC; Firulli AB; Carlesso N; Towbin JA; Shou W. 2013. Fkbp1a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch1 activity. Development 140(9):1946-57. [PubMed: 23571217] [MGI Ref ID J:195489]
Clark R; Mannikko R; Stuckey DJ; Iberl M; Clarke K; Ashcroft FM. 2012. Mice expressing a human K(ATP) channel mutation have altered channel ATP sensitivity but no cardiac abnormalities. Diabetologia 55(4):1195-204. [PubMed: 22252471] [MGI Ref ID J:181882]
Clark RH; McTaggart JS; Webster R; Mannikko R; Iberl M; Sim XL; Rorsman P; Glitsch M; Beeson D; Ashcroft FM. 2010. Muscle dysfunction caused by a KATP channel mutation in neonatal diabetes is neuronal in origin. Science 329(5990):458-61. [PubMed: 20595581] [MGI Ref ID J:162008]
Cohen SE; Kokkotou E; Biddinger SB; Kondo T; Gebhardt R; Kratzsch J; Mantzoros CS; Kahn CR. 2007. High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice. J Biol Chem 282(32):23672-8. [PubMed: 17556363] [MGI Ref ID J:124577]
Cohn RD; Henry MD; Michele DE; Barresi R; Saito F; Moore SA; Flanagan JD; Skwarchuk MW; Robbins ME; Mendell JR; Williamson RA; Campbell KP. 2002. Disruption of DAG1 in differentiated skeletal muscle reveals a role for dystroglycan in muscle regeneration. Cell 110(5):639-48. [PubMed: 12230980] [MGI Ref ID J:78838]
Crackower MA; Oudit GY; Kozieradzki I; Sarao R; Sun H; Sasaki T; Hirsch E; Suzuki A; Shioi T; Irie-Sasaki J; Sah R; Cheng HY; Rybin VO; Lembo G; Fratta L; Oliveira-dos-Santos AJ; Benovic JL; Kahn CR; Izumo S; Steinberg SF; Wymann MP; Backx PH; Penninger JM. 2002. Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell 110(6):737-49. [PubMed: 12297047] [MGI Ref ID J:79151]
Delibegovic M; Bence KK; Mody N; Hong EG; Ko HJ; Kim JK; Kahn BB; Neel BG. 2007. Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B. Mol Cell Biol 27(21):7727-34. [PubMed: 17724080] [MGI Ref ID J:129081]
Duvezin-Caubet S; Jagasia R; Wagener J; Hofmann S; Trifunovic A; Hansson A; Chomyn A; Bauer MF; Attardi G; Larsson NG; Neupert W; Reichert AS. 2006. Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology. J Biol Chem 281(49):37972-9. [PubMed: 17003040] [MGI Ref ID J:117614]
Ealey KN; Lu S; Lau D; Archer MC. 2008. Reduced susceptibility of muscle-specific insulin receptor knockout mice to colon carcinogenesis. Am J Physiol Gastrointest Liver Physiol 294(3):G679-86. [PubMed: 18174274] [MGI Ref ID J:132394]
Farese RV; Sajan MP; Yang H; Li P; Mastorides S; Gower WR Jr; Nimal S; Choi CS; Kim S; Shulman GI; Kahn CR; Braun U; Leitges M. 2007. Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes. J Clin Invest 117(8):2289-301. [PubMed: 17641777] [MGI Ref ID J:123964]
Foretz M; Hebrard S; Leclerc J; Zarrinpashneh E; Soty M; Mithieux G; Sakamoto K; Andreelli F; Viollet B. 2010. Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. J Clin Invest 120(7):2355-69. [PubMed: 20577053] [MGI Ref ID J:163780]
Fornaro M; Burch PM; Yang W; Zhang L; Hamilton CE; Kim JH; Neel BG; Bennett AM. 2006. SHP-2 activates signaling of the nuclear factor of activated T cells to promote skeletal muscle growth. J Cell Biol 175(1):87-97. [PubMed: 17015617] [MGI Ref ID J:114499]
Frost RJ; Olson EN. 2011. Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs. Proc Natl Acad Sci U S A 108(52):21075-80. [PubMed: 22160727] [MGI Ref ID J:180138]
Gao Y; Katyal S; Lee Y; Zhao J; Rehg JE; Russell HR; McKinnon PJ. 2011. DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair. Nature 471(7337):240-4. [PubMed: 21390131] [MGI Ref ID J:170077]
Gilson H; Schakman O; Combaret L; Lause P; Grobet L; Attaix D; Ketelslegers JM; Thissen JP. 2007. Myostatin gene deletion prevents glucocorticoid-induced muscle atrophy. Endocrinology 148(1):452-60. [PubMed: 17038559] [MGI Ref ID J:129558]
Gilson H; Schakman O; Kalista S; Lause P; Tsuchida K; Thissen JP. 2009. Follistatin induces muscle hypertrophy through satellite cell proliferation and inhibition of both myostatin and activin. Am J Physiol Endocrinol Metab 297(1):E157-64. [PubMed: 19435857] [MGI Ref ID J:151164]
Goransson O; McBride A; Hawley SA; Ross FA; Shpiro N; Foretz M; Viollet B; Hardie DG; Sakamoto K. 2007. Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. J Biol Chem 282(45):32549-60. [PubMed: 17855357] [MGI Ref ID J:126943]
Gotthardt M; Hammer RE; Hubner N; Monti J; Witt CC; McNabb M; Richardson JA; Granzier H; Labeit S; Herz J. 2003. Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure. J Biol Chem 278(8):6059-65. [PubMed: 12464612] [MGI Ref ID J:81993]
Grobet L; Pirottin D; Farnir F; Poncelet D; Royo LJ; Brouwers B; Christians E; Desmecht D; Coignoul F; Kahn R; Georges M. 2003. Modulating skeletal muscle mass by postnatal, muscle-specific inactivation of the myostatin gene. Genesis 35(4):227-38. [PubMed: 12717734] [MGI Ref ID J:83122]
Habets DD; Coumans WA; El Hasnaoui M; Zarrinpashneh E; Bertrand L; Viollet B; Kiens B; Jensen TE; Richter EA; Bonen A; Glatz JF; Luiken JJ. 2009. Crucial role for LKB1 to AMPKalpha2 axis in the regulation of CD36-mediated long-chain fatty acid uptake into cardiomyocytes. Biochim Biophys Acta 1791(3):212-9. [PubMed: 19159696] [MGI Ref ID J:148739]
Haemmerle G; Moustafa T; Woelkart G; Buttner S; Schmidt A; van de Weijer T; Hesselink M; Jaeger D; Kienesberger PC; Zierler K; Schreiber R; Eichmann T; Kolb D; Kotzbeck P; Schweiger M; Kumari M; Eder S; Schoiswohl G; Wongsiriroj N; Pollak NM; Radner FP; Preiss-Landl K; Kolbe T; Rulicke T; Pieske B; Trauner M; Lass A; Zimmermann R; Hoefler G; Cinti S; Kershaw EE; Schrauwen P; Madeo F; Mayer B; Zechner R. 2011. ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-alpha and PGC-1. Nat Med 17(9):1076-85. [PubMed: 21857651] [MGI Ref ID J:176252]
Han R; Kanagawa M; Yoshida-Moriguchi T; Rader EP; Ng RA; Michele DE; Muirhead DE; Kunz S; Moore SA; Iannaccone ST; Miyake K; McNeil PL; Mayer U; Oldstone MB; Faulkner JA; Campbell KP. 2009. Basal lamina strengthens cell membrane integrity via the laminin G domain-binding motif of alpha-dystroglycan. Proc Natl Acad Sci U S A 106(31):12573-9. [PubMed: 19633189] [MGI Ref ID J:152005]
Hansson A; Hance N; Dufour E; Rantanen A; Hultenby K; Clayton DA; Wibom R; Larsson NG. 2004. A switch in metabolism precedes increased mitochondrial biogenesis in respiratory chain-deficient mouse hearts. Proc Natl Acad Sci U S A 101(9):3136-41. [PubMed: 14978272] [MGI Ref ID J:88652]
Hara Y; Balci-Hayta B; Yoshida-Moriguchi T; Kanagawa M; Beltran-Valero de Bernabe D; Gundesli H; Willer T; Satz JS; Crawford RW; Burden SJ; Kunz S; Oldstone MB; Accardi A; Talim B; Muntoni F; Topaloglu H; Dincer P; Campbell KP. 2011. A Dystroglycan Mutation Associated with Limb-Girdle Muscular Dystrophy. N Engl J Med 364(10):939-946. [PubMed: 21388311] [MGI Ref ID J:169291]
Hasumi H; Baba M; Hasumi Y; Huang Y; Oh H; Hughes RM; Klein ME; Takikita S; Nagashima K; Schmidt LS; Linehan WM. 2012. Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN. J Natl Cancer Inst 104(22):1750-64. [PubMed: 23150719] [MGI Ref ID J:192024]
Hatley ME; Tang W; Garcia MR; Finkelstein D; Millay DP; Liu N; Graff J; Galindo RL; Olson EN. 2012. A mouse model of rhabdomyosarcoma originating from the adipocyte lineage. Cancer Cell 22(4):536-46. [PubMed: 23079662] [MGI Ref ID J:192027]
He Y; Hakvoort TB; Kohler SE; Vermeulen JL; de Waart DR; de Theije C; ten Have GA; van Eijk HM; Kunne C; Labruyere WT; Houten SM; Sokolovic M; Ruijter JM; Deutz NE; Lamers WH. 2010. Glutamine synthetase in muscle is required for glutamine production during fasting and extrahepatic ammonia detoxification. J Biol Chem 285(13):9516-24. [PubMed: 20064933] [MGI Ref ID J:161082]
Herrmann S; Stieber J; Stockl G; Hofmann F; Ludwig A. 2007. HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice. EMBO J 26(21):4423-32. [PubMed: 17914461] [MGI Ref ID J:139560]
Hesser BA; Henschel O; Witzemann V. 2006. Synapse disassembly and formation of new synapses in postnatal muscle upon conditional inactivation of MuSK. Mol Cell Neurosci 31(3):470-80. [PubMed: 16337809] [MGI Ref ID J:106867]
Hevener AL; He W; Barak Y; Le J; Bandyopadhyay G; Olson P; Wilkes J; Evans RM; Olefsky J. 2003. Muscle-specific Pparg deletion causes insulin resistance. Nat Med 9(12):1491-7. [PubMed: 14625542] [MGI Ref ID J:86773]
Hu J; Du J; Zhang L; Price SR; Klein JD; Wang XH. 2010. XIAP reduces muscle proteolysis induced by CKD. J Am Soc Nephrol 21(7):1174-83. [PubMed: 20431038] [MGI Ref ID J:185934]
Hu P; Zhang D; Swenson L; Chakrabarti G; Abel ED; Litwin SE. 2003. Minimally invasive aortic banding in mice: effects of altered cardiomyocyte insulin signaling during pressure overload. Am J Physiol Heart Circ Physiol 285(3):H1261-9. [PubMed: 12738623] [MGI Ref ID J:85401]
Hu Z; Wang H; Lee IH; Du J; Mitch WE. 2009. Endogenous glucocorticoids and impaired insulin signaling are both required to stimulate muscle wasting under pathophysiological conditions in mice. J Clin Invest 119(10):3059-69. [PubMed: 19759515] [MGI Ref ID J:154640]
Hu Z; Wang H; Lee IH; Modi S; Wang X; Du J; Mitch WE. 2010. PTEN inhibition improves muscle regeneration in mice fed a high-fat diet. Diabetes 59(6):1312-20. [PubMed: 20200318] [MGI Ref ID J:169364]
Hui ST; Andres AM; Miller AK; Spann NJ; Potter DW; Post NM; Chen AZ; Sachithanantham S; Jung DY; Kim JK; Davis RA. 2008. Txnip balances metabolic and growth signaling via PTEN disulfide reduction. Proc Natl Acad Sci U S A 105(10):3921-6. [PubMed: 18322014] [MGI Ref ID J:132756]
Ikeda Y; Sato K; Pimentel DR; Sam F; Shaw RJ; Dyck JR; Walsh K. 2009. Cardiac-specific deletion of LKB1 leads to hypertrophy and dysfunction. J Biol Chem 284(51):35839-49. [PubMed: 19828446] [MGI Ref ID J:158214]
Inazuka F; Sugiyama N; Tomita M; Abe T; Shioi G; Esumi H. 2012. Muscle-specific knock-out of NUAK family SNF1-like kinase 1 (NUAK1) prevents high fat diet-induced glucose intolerance. J Biol Chem 287(20):16379-89. [PubMed: 22418434] [MGI Ref ID J:185463]
Iwabu M; Yamauchi T; Okada-Iwabu M; Sato K; Nakagawa T; Funata M; Yamaguchi M; Namiki S; Nakayama R; Tabata M; Ogata H; Kubota N; Takamoto I; Hayashi YK; Yamauchi N; Waki H; Fukayama M; Nishino I; Tokuyama K; Ueki K; Oike Y; Ishii S; Hirose K; Shimizu T;Touhara K; Kadowaki T. 2010. Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1. Nature 464(7293):1313-9. [PubMed: 20357764] [MGI Ref ID J:159462]
Jaber N; Dou Z; Chen JS; Catanzaro J; Jiang YP; Ballou LM; Selinger E; Ouyang X; Lin RZ; Zhang J; Zong WX. 2012. Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function. Proc Natl Acad Sci U S A 109(6):2003-8. [PubMed: 22308354] [MGI Ref ID J:182628]
Jessen N; Koh HJ; Folmes CD; Wagg C; Fujii N; Lofgren B; Wolf CM; Berul CI; Hirshman MF; Lopaschuk GD; Goodyear LJ. 2010. Ablation of LKB1 in the heart leads to energy deprivation and impaired cardiac function. Biochim Biophys Acta 1802(7-8):593-600. [PubMed: 20441792] [MGI Ref ID J:165362]
Joza N; Oudit GY; Brown D; Benit P; Kassiri Z; Vahsen N; Benoit L; Patel MM; Nowikovsky K; Vassault A; Backx PH; Wada T; Kroemer G; Rustin P; Penninger JM. 2005. Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy. Mol Cell Biol 25(23):10261-72. [PubMed: 16287843] [MGI Ref ID J:113016]
Kim JK; Michael MD; Previs SF; Peroni OD; Mauvais-Jarvis F; Neschen S; Kahn BB; Kahn CR; Shulman GI. 2000. Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle. J Clin Invest 105(12):1791-7. [PubMed: 10862794] [MGI Ref ID J:120531]
Kim JK; Zisman A; Fillmore JJ; Peroni OD; Kotani K; Perret P; Zong H; Dong J; Kahn CR; Kahn BB; Shulman GI. 2001. Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4. J Clin Invest 108(1):153-60. [PubMed: 11435467] [MGI Ref ID J:110773]
Kleinridders A; Pogoda HM; Irlenbusch S; Smyth N; Koncz C; Hammerschmidt M; Bruning JC. 2009. PLRG1 is an essential regulator of cell proliferation and apoptosis during vertebrate development and tissue homeostasis. Mol Cell Biol 29(11):3173-85. [PubMed: 19307306] [MGI Ref ID J:149153]
Knauf C; Cani PD; Perrin C; Iglesias MA; Maury JF; Bernard E; Benhamed F; Gremeaux T; Drucker DJ; Kahn CR; Girard J; Tanti JF; Delzenne NM; Postic C; Burcelin R. 2005. Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage. J Clin Invest 115(12):3554-63. [PubMed: 16322793] [MGI Ref ID J:104705]
Kobuke K; Piccolo F; Garringer KW; Moore SA; Sweezer E; Yang B; Campbell KP. 2008. A Common Disease-Associated Missense Mutation in Alpha-Sarcoglycan Fails to Cause Muscular Dystrophy in Mice. Hum Mol Genet :. [PubMed: 18252746] [MGI Ref ID J:130252]
Koh HJ; Arnolds DE; Fujii N; Tran TT; Rogers MJ; Jessen N; Li Y; Liew CW; Ho RC; Hirshman MF; Kulkarni RN; Kahn CR; Goodyear LJ. 2006. Skeletal Muscle-Selective Knockout of LKB1 Increases Insulin Sensitivity, Improves Glucose Homeostasis, and Decreases TRB3. Mol Cell Biol 26(22):8217-27. [PubMed: 16966378] [MGI Ref ID J:114640]
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Zisman A; Peroni OD; Abel ED; Michael MD; Mauvais-Jarvis F; Lowell BB; Wojtaszewski JF; Hirshman MF; Virkamaki A; Goodyear LJ; Kahn CR; Kahn BB. 2000. Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nat Med 6(8):924-8. [PubMed: 10932232] [MGI Ref ID J:75418]
Zu L; Zheng X; Wang B; Parajuli N; Steenbergen C; Becker LC; Cai ZP. 2011. Ischemic Preconditioning Attenuates Mitochondrial Localization of PTEN Induced by Ischemia-Reperfusion. Am J Physiol Heart Circ Physiol :. [PubMed: 21421815] [MGI Ref ID J:170450]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX11
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, these mice are bred as hemizygotes. While the donating investigator has not attempted to make this strain homozygous, viability of homozygous mice is expected. Mating System Noncarrier x Hemizygote (Female x Male) 11-DEC-12 Hemizygote x Noncarrier (Female x Male) 11-DEC-12 Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $232.00 Female or Male Hemizygous for Tg(Ckmm-cre)5Khn
Price per Pair (US dollars $) Pair Genotype $302.00 Hemizygous for Tg(Ckmm-cre)5Khn x Noncarrier $302.00 Noncarrier x Hemizygous for Tg(Ckmm-cre)5Khn Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
| Pricing for International shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $301.60 Female or Male Hemizygous for Tg(Ckmm-cre)5Khn
Price per Pair (US dollars $) Pair Genotype $392.60 Hemizygous for Tg(Ckmm-cre)5Khn x Noncarrier $392.60 Noncarrier x Hemizygous for Tg(Ckmm-cre)5Khn Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
|
|
|
Standard Supply
Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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Terms of Use
Terms of Use
General Terms and Conditions
Contact information
General inquiries regarding Terms of UseContracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.