Strain Name:

CByJ.129S2(B6)-Cd4tm1Mak/J

Stock Number:

006483

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Availability:

Cryopreserved - Ready for recovery

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Cell surface expression of CD4 protein is not detected on thymocytes and lymph node cells from mice homozygous for this Cd4 (CD4 antigen) targeted mutation. Homozygous mutant mice also show a Class II restricted deficit in helper T-cell activity and other T-cell responses. This mutant mouse strain may be useful in studies of T cell development, susceptibility to viral infection and inflammation.

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names CBy.129S2(B6)-Cd4tm1Mak/J    (Changed: 02-MAR-12 )
Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
GenerationN5F2pN1
Generation Definitions
 
Donating Investigator IMR Colony,   The Jackson Laboratory

Description
Mice homozygous for the Cd4tm1Mak targeted mutation have a significant block in CD4+ T-cell development; 90% of their circulating T-cells are CD8+. Cell surface expression of CD4 protein is not detected on thymocytes and lymph node cells from homozygous mice. Homozygous mutant mice also show a Class II restricted deficit in helper T-cell activity and other T-cell responses. This mutant mouse strain may be useful in studies of T cell development, susceptibility to viral infection and inflammation.

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

Development
A targeting vector containing a PGK-neo cassette was used to disrupt exon 5. The construct was electroporated into 129S2/SvPas derived D3 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts. The mice were crossed to C57BL/6 mice for 8 generations, and then backcrossed to BALB/cByJ for at least 5 generations.

Control Information

  Control
   001026 BALB/cByJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Cd4tm1Mak allele
002663   B6.129S2-Cd4tm1Mak/J
002664   B6;129S-Cd4tm1Mak Cd8atm1Mak/J
View Strains carrying   Cd4tm1Mak     (2 strains)

View Strains carrying other alleles of Cd4     (13 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Okt4 Epitope Deficiency   (CD4)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Cd4tm1Mak/Cd4tm1Mak

        involves: 129S2/SvPas * C57BL/6 * DBA/2
  • hematopoietic system phenotype
  • abnormal CD4-positive, alpha-beta T cell physiology
    • no response to class II alloantigens, but normal class I   (MGI Ref ID J:68957)
  • increased CD8-positive, alpha-beta T cell number
    • peripheral CD8+ cell population is expanded   (MGI Ref ID J:68957)
  • immune system phenotype
  • abnormal CD4-positive, alpha-beta T cell physiology
    • no response to class II alloantigens, but normal class I   (MGI Ref ID J:68957)
  • increased CD8-positive, alpha-beta T cell number
    • peripheral CD8+ cell population is expanded   (MGI Ref ID J:68957)
  • increased susceptibility to viral infection
    • significantly increased inflammation in the first week of TMEV infection which is mostly resolved by 45 days after infection on the resistant C57BL/6 background   (MGI Ref ID J:92227)
    • persistent infectious virus at 45 days and increasing clinical symptoms over time   (MGI Ref ID J:92227)
    • at 10 months, 93% of mice present clinical symptoms on the resistant C57BL/6 background   (MGI Ref ID J:92227)
  • nervous system phenotype
  • demyelination
    • on the resistant C57BL/6 background, demyelination was light at 45 days after TMEV infection, but extensive at 90 days   (MGI Ref ID J:92227)

Cd4tm1Mak/Cd4tm1Mak

        P/J
  • immune system phenotype
  • brain inflammation
    • severely increased meningeal inflammation on both PL/J and SJL/J backgrounds after infection with TMEV   (MGI Ref ID J:92227)
  • increased susceptibility to viral infection
    • inflammation persists in the susceptible PL/J background, particularly in the cerebellum, brainstem and striatum   (MGI Ref ID J:92227)
  • nervous system phenotype
  • brain inflammation
    • severely increased meningeal inflammation on both PL/J and SJL/J backgrounds after infection with TMEV   (MGI Ref ID J:92227)
  • demyelination
    • demyelination was severe on both the susceptible PL/J and SJL/J backgrounds after infection with TMEV   (MGI Ref ID J:92227)

Cd4tm1Mak/Cd4tm1Mak

        SJL/J
  • immune system phenotype
  • brain inflammation
    • severely increased meningeal inflammation on both PL/J and SJL/J backgrounds after infection with TMEV   (MGI Ref ID J:92227)
  • increased susceptibility to viral infection
    • inflammation persists in the susceptible SJL/J background, particularly in the cerebellum, brainstem and striatum   (MGI Ref ID J:92227)
  • nervous system phenotype
  • brain inflammation
    • severely increased meningeal inflammation on both PL/J and SJL/J backgrounds after infection with TMEV   (MGI Ref ID J:92227)
  • demyelination
    • demyelination was severe on both the susceptible PL/J and SJL/J backgrounds after infection with TMEV   (MGI Ref ID J:92227)

Cd4tm1Mak/Cd4tm1Mak

        involves: 129S2/SvPas
  • immune system phenotype
  • *normal* immune system phenotype
    • mice clear polyomavirus within one month of infection similar to controls   (MGI Ref ID J:110749)

Cd4tm1Mak/Cd4tm1Mak

        B6.129S2-Cd4tm1Mak/J
  • immune system phenotype
  • *normal* immune system phenotype   (MGI Ref ID J:133047)
    • absent plasma cells   (MGI Ref ID J:133047)
  • hematopoietic system phenotype
  • absent plasma cells   (MGI Ref ID J:133047)
  • homeostasis/metabolism phenotype
  • abnormal bile salt level   (MGI Ref ID J:133047)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research
Immunodeficiency
      T cell deficiency

Research Tools
Immunology, Inflammation and Autoimmunity Research
      genes regulating susceptibility to infectious disease and endotoxin

Virology Research

Cd4tm1Mak related

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Cd4tm1Mak
Allele Name targeted mutation 1, Tak Mak
Allele Type Targeted (Null/Knockout)
Common Name(s) CD4 KO; CD4-; CD40;
Mutation Made ByDr. Tak Mak,   University Health Network/Un of Toronto
Strain of Origin129S2/SvPas
ES Cell Line NameD3
ES Cell Line Strain129S2/SvPas
Gene Symbol and Name Cd4, CD4 antigen
Chromosome 6
Gene Common Name(s) CD4mut; L3T4; Ly-4; W3/25; lymphocyte antigen 4; p55;
Molecular Note A neomycin resistance cassette was inserted into exon 5. Flow cytometry analysis demonstrated that the protein was absent from the cell surface of thymocytes and lymph node cells in homozygous mice. [MGI Ref ID J:68957]

Genotyping

Genotyping Information

Genotyping Protocols

Generic Cd4, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Cd4tm1Mak related

Adoro S; Erman B; Sarafova SD; Van Laethem F; Park JH; Feigenbaum L; Singer A. 2008. Targeting CD4 coreceptor expression to postselection thymocytes reveals that CD4/CD8 lineage choice is neither error-prone nor stochastic. J Immunol 181(10):6975-83. [PubMed: 18981117]  [MGI Ref ID J:140942]

Adoro S; McCaughtry T; Erman B; Alag A; Van Laethem F; Park JH; Tai X; Kimura M; Wang L; Grinberg A; Kubo M; Bosselut R; Love P; Singer A. 2011. Coreceptor gene imprinting governs thymocyte lineage fate. EMBO J 31(2):366-77. [PubMed: 22036949]  [MGI Ref ID J:180236]

Antony PA; Piccirillo CA; Akpinarli A; Finkelstein SE; Speiss PJ; Surman DR; Palmer DC; Chan CC; Klebanoff CA; Overwijk WW; Rosenberg SA; Restifo NP. 2005. CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells. J Immunol 174(5):2591-601. [PubMed: 15728465]  [MGI Ref ID J:129825]

Bachmaier K; Neu N; Yeung RS; Mak TW; Liu P; Penninger JM. 1999. Generation of humanized mice susceptible to peptide-induced inflammatory heart disease. Circulation 99(14):1885-91. [PubMed: 10199887]  [MGI Ref ID J:129115]

Battegay M; Moskophidis D; Rahemtulla A; Hengartner H; Mak TW; Zinkernagel RM. 1994. Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice. J Virol 68(7):4700-4. [PubMed: 7911534]  [MGI Ref ID J:18756]

Bayer AL; Chirinos J; Cabello C; Yang J; Matsutani T; Malek TR; Levy RB. 2011. Expansion of a restricted residual host T reg-cell repertoire is dependent on IL-2 following experimental autologous hematopoietic stem transplantation. Eur J Immunol 41(12):3467-78. [PubMed: 21928285]  [MGI Ref ID J:179509]

Bedenikovic G; Crouse J; Oxenius A. 2014. T-cell help dependence of memory CD8+ T-cell expansion upon vaccinia virus challenge relies on CD40 signaling. Eur J Immunol 44(1):115-26. [PubMed: 24108445]  [MGI Ref ID J:208658]

Berke Z; Wen T; Jin S; Klein G; Dalianis T. 1995. Polyomavirus persists in CD4/8 double-knockout, but not in CD4 or CD8 single-knockout mice. Virology 212(1):268-71. [PubMed: 7676644]  [MGI Ref ID J:110749]

Berke Z; Wen T; Klein G; Dalianis T. 1996. Polyoma tumor development in neonatally polyoma-virus-infected CD4-/- and CD8-/- single knockout and CD4-/-8-/- double knockout mice. Int J Cancer 67(3):405-8. [PubMed: 8707416]  [MGI Ref ID J:113042]

Bitsaktsis C; Huntington J; Winslow G. 2004. Production of IFN-gamma by CD4 T cells is essential for resolving ehrlichia infection. J Immunol 172(11):6894-901. [PubMed: 15153508]  [MGI Ref ID J:90518]

Bitsaktsis C; Nandi B; Racine R; MacNamara KC; Winslow G. 2007. T-Cell-independent humoral immunity is sufficient for protection against fatal intracellular ehrlichia infection. Infect Immun 75(10):4933-41. [PubMed: 17664264]  [MGI Ref ID J:125283]

Black KE; Murray JA; David CS. 2002. HLA-DQ Determines the Response to Exogenous Wheat Proteins: A Model of Gluten Sensitivity in Transgenic Knockout Mice. J Immunol 169(10):5595-600. [PubMed: 12421937]  [MGI Ref ID J:80059]

Blazar BR; Lees CJ; Martin PJ; Noelle RJ; Kwon B; Murphy W; Taylor PA. 2000. Host T cells resist graft-versus-host disease mediated by donor leukocyte infusions. J Immunol 165(9):4901-9. [PubMed: 11046015]  [MGI Ref ID J:118027]

Boenisch O; D'Addio F; Watanabe T; Elyaman W; Magee CN; Yeung MY; Padera RF; Rodig SJ; Murayama T; Tanaka K; Yuan X; Ueno T; Jurisch A; Mfarrej B; Akiba H; Yagita H; Najafian N. 2010. TIM-3: a novel regulatory molecule of alloimmune activation. J Immunol 185(10):5806-19. [PubMed: 20956339]  [MGI Ref ID J:165781]

Borenstein SH; Graham J; Zhang XL; Chamberlain JW. 2000. CD8+ T cells are necessary for recognition of allelic, but not locus-mismatched or xeno-, HLA class I transplantation antigens. J Immunol 165(5):2341-53. [PubMed: 10946256]  [MGI Ref ID J:80678]

Burne MJ; Daniels F; El Ghandour A; Mauiyyedi S; Colvin RB; O'Donnell MP; Rabb H. 2001. Identification of the CD4(+) T cell as a major pathogenic factor in ischemic acute renal failure. J Clin Invest 108(9):1283-90. [PubMed: 11696572]  [MGI Ref ID J:118005]

Caldwell CC; Okaya T; Martignoni A; Husted T; Schuster R; Lentsch AB. 2005. Divergent functions of CD4+ T lymphocytes in acute liver inflammation and injury after ischemia-reperfusion. Am J Physiol Gastrointest Liver Physiol 289(5):G969-76. [PubMed: 16002566]  [MGI Ref ID J:104787]

Chan K; Lee DJ; Schubert A; Tang CM; Crain B; Schoenberger SP; Corr M. 2001. The roles of MHC class II, CD40, and B7 costimulation in CTL induction by plasmid DNA. J Immunol 166(5):3061-6. [PubMed: 11207256]  [MGI Ref ID J:126695]

Chan WC; Duong TT; Yeung RS. 2004. Presence of IFN-gamma does not indicate its necessity for induction of coronary arteritis in an animal model of Kawasaki disease. J Immunol 173(5):3492-503. [PubMed: 15322214]  [MGI Ref ID J:92708]

Chapoval SP; Iijima K; Marietta EV; Smart MK; Chapoval AI; Andrews AG; David CS. 2002. Allergic inflammatory response to short ragweed allergenic extract in HLA-DQ transgenic mice lacking CD4 gene. J Immunol 168(2):890-9. [PubMed: 11777987]  [MGI Ref ID J:73744]

Chapoval SP; Marietta EV; Smart MK; David CS. 2001. Requirements for allergen-induced airway inflammation and hyperreactivity in CD4-deficient and CD4-sufficient HLA-DQ transgenic mice. J Allergy Clin Immunol 108(5):764-71. [PubMed: 11692102]  [MGI Ref ID J:106479]

Chen SY; Takeoka Y; Ansari AA; Boyd R; Klinman DM; Gershwin ME. 1996. The natural history of disease expression in CD4 and CD8 gene-deleted New Zealand black (NZB) mice. J Immunol 157(6):2676-84. [PubMed: 8805673]  [MGI Ref ID J:35433]

Chen Z; Yu S; Concha HQ; Zhu Y; Mix E; Winblad B; Ljunggren HG; Zhu J. 2004. Kainic acid-induced excitotoxic hippocampal neurodegeneration in C57BL/6 mice: B cell and T cell subsets may contribute differently to the pathogenesis. Brain Behav Immun 18(2):175-85. [PubMed: 14759595]  [MGI Ref ID J:105331]

Chiang EY; Stroynowski I. 2004. A nonclassical MHC class I molecule restricts CTL-mediated rejection of a syngeneic melanoma tumor. J Immunol 173(7):4394-401. [PubMed: 15383569]  [MGI Ref ID J:93729]

Chiu BC; Martin BE; Stolberg VR; Chensue SW. 2013. Cutting edge: Central memory CD8 T cells in aged mice are virtual memory cells. J Immunol 191(12):5793-6. [PubMed: 24227783]  [MGI Ref ID J:207125]

Choo DK; Murali-Krishna K; Anita R; Ahmed R. 2010. Homeostatic turnover of virus-specific memory CD8 T cells occurs stochastically and is independent of CD4 T cell help. J Immunol 185(6):3436-44. [PubMed: 20733203]  [MGI Ref ID J:163530]

Choudhury A; Cohen PL; Eisenberg RA. 2010. B cells require 'nurturing' by CD4 T cells during development in order to respond in chronic graft-versus-host model of systemic lupus erythematosus. Clin Immunol :. [PubMed: 20381429]  [MGI Ref ID J:160847]

Choudhury A; Maldonado MA; Cohen PL; Eisenberg RA. 2005. The role of host CD4 T cells in the pathogenesis of the chronic graft-versus-host model of systemic lupus erythematosus. J Immunol 174(12):7600-9. [PubMed: 15944260]  [MGI Ref ID J:100787]

Cuzzone DA; Weitman ES; Albano NJ; Ghanta S; Savetsky IL; Gardenier JC; Joseph WJ; Torrisi JS; Bromberg JF; Olszewski WL; Rockson SG; Mehrara BJ. 2014. IL-6 regulates adipose deposition and homeostasis in lymphedema. Am J Physiol Heart Circ Physiol 306(10):H1426-34. [PubMed: 24633552]  [MGI Ref ID J:211549]

Daniel D; Chiu C; Giraudo E; Inoue M; Mizzen LA; Chu NR; Hanahan D. 2005. CD4+ T cell-mediated antigen-specific immunotherapy in a mouse model of cervical cancer. Cancer Res 65(5):2018-25. [PubMed: 15753402]  [MGI Ref ID J:97006]

Daniel D; Meyer-Morse N; Bergsland EK; Dehne K; Coussens LM; Hanahan D. 2003. Immune Enhancement of Skin Carcinogenesis by CD4+ T Cells. J Exp Med 197(8):1017-28. [PubMed: 12695493]  [MGI Ref ID J:82978]

Dautigny N; Le Campion A; Lucas B. 1999. Timing and casting for actors of thymic negative selection. J Immunol 162(3):1294-302. [PubMed: 9973382]  [MGI Ref ID J:124433]

DeNardo DG; Barreto JB; Andreu P; Vasquez L; Tawfik D; Kolhatkar N; Coussens LM. 2009. CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell 16(2):91-102. [PubMed: 19647220]  [MGI Ref ID J:151976]

Derrick SC; Evering TH; Sambandamurthy VK; Jalapathy KV; Hsu T; Chen B; Chen M; Russell RG; Junqueira-Kipnis AP; Orme IM; Porcelli SA; Jacobs WR Jr; Morris SL. 2007. Characterization of the protective T-cell response generated in CD4-deficient mice by a live attenuated Mycobacterium tuberculosis vaccine. Immunology 120(2):192-206. [PubMed: 17076705]  [MGI Ref ID J:122314]

Di Piazza M; Nowell CS; Koch U; Durham AD; Radtke F. 2012. Loss of cutaneous TSLP-dependent immune responses skews the balance of inflammation from tumor protective to tumor promoting. Cancer Cell 22(4):479-93. [PubMed: 23079658]  [MGI Ref ID J:192029]

Dispirito JR; Shen H. 2010. Histone acetylation at the single-cell level: a marker of memory CD8(+) T cell differentiation and functionality. J Immunol 184(9):4631-6. [PubMed: 20308634]  [MGI Ref ID J:160485]

Do JS; Valujskikh A; Vignali DA; Fairchild RL; Min B. 2012. Unexpected role for MHC II-peptide complexes in shaping CD8 T-cell expansion and differentiation in vivo. Proc Natl Acad Sci U S A 109(31):12698-703. [PubMed: 22802622]  [MGI Ref ID J:188517]

Duong TT; Silverman ED; Bissessar MV; Yeung RS. 2003. Superantigenic activity is responsible for induction of coronary arteritis in mice: an animal model of Kawasaki disease. Int Immunol 15(1):79-89. [PubMed: 12502728]  [MGI Ref ID J:81746]

Ehinger M; Vestberg M; Johansson AC; Johannesson M; Svensson A; Holmdahl R. 2001. Influence of CD4 or CD8 deficiency on collagen-induced arthritis. Immunology 103(3):291-300. [PubMed: 11454058]  [MGI Ref ID J:110421]

Fenster CP; Chisnell HK; Fry CR; Fenster SD. 2010. The role of CD4-dependent signaling in interleukin-16 induced c-Fos expression and facilitation of neurite outgrowth in cerebellar granule neurons. Neurosci Lett 485(3):212-6. [PubMed: 20849916]  [MGI Ref ID J:167253]

Fischbein MP; Ardehali A; Yun J; Schoenberger S; Laks H; Irie Y; Dempsey P; Cheng G; Fishbein MC; Bonavida B. 2000. CD40 signaling replaces CD4+ lymphocytes and its blocking prevents chronic rejection of heart transplants. J Immunol 165(12):7316-22. [PubMed: 11120867]  [MGI Ref ID J:118395]

Flano E; Woodland DL; Blackman MA. 1999. Requirement for CD4+ T cells in V beta 4+CD8+ T cell activation associated with latent murine gammaherpesvirus infection. J Immunol 163(6):3403-8. [PubMed: 10477611]  [MGI Ref ID J:119171]

Freland S; Ljunggren H. 2000. beta2-Microglobulin/CD8 -/- mice reveal significant role for CD8+ T cells in graft rejection responses in beta2-microglobulin -/- mice Scand J Immunol 51(3):219-23. [PubMed: 10736089]  [MGI Ref ID J:61231]

Fuller MJ; Khanolkar A; Tebo AE; Zajac AJ. 2004. Maintenance, loss, and resurgence of T cell responses during acute, protracted, and chronic viral infections. J Immunol 172(7):4204-14. [PubMed: 15034033]  [MGI Ref ID J:88714]

Ganesan AP; Johansson M; Ruffell B; Yagui-Beltran A; Lau J; Jablons DM; Coussens LM. 2013. Tumor-infiltrating regulatory T cells inhibit endogenous cytotoxic T cell responses to lung adenocarcinoma. J Immunol 191(4):2009-17. [PubMed: 23851682]  [MGI Ref ID J:205696]

Gray EE; Friend S; Suzuki K; Phan TG; Cyster JG. 2012. Subcapsular sinus macrophage fragmentation and CD169+ bleb acquisition by closely associated IL-17-committed innate-like lymphocytes. PLoS One 7(6):e38258. [PubMed: 22675532]  [MGI Ref ID J:187848]

Grayson MH; Cheung D; Rohlfing MM; Kitchens R; Spiegel DE; Tucker J; Battaile JT; Alevy Y; Yan L; Agapov E; Kim EY; Holtzman MJ. 2007. Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia. J Exp Med 204(11):2759-69. [PubMed: 17954569]  [MGI Ref ID J:126124]

Grueter B; Petter M; Egawa T; Laule-Kilian K; Aldrian CJ; Wuerch A; Ludwig Y; Fukuyama H; Wardemann H; Waldschuetz R; Moroy T; Taniuchi I; Steimle V; Littman DR; Ehlers M. 2005. Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cells. J Immunol 175(3):1694-705. [PubMed: 16034110]  [MGI Ref ID J:107280]

Guarda G; Dostert C; Staehli F; Cabalzar K; Castillo R; Tardivel A; Schneider P; Tschopp J. 2009. T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes. Nature 460(7252):269-73. [PubMed: 19494813]  [MGI Ref ID J:150357]

Heemskerk MH; Schilham MW; Schoemaker HM; Spierenburg G; Spaan WJ; Boog CJ. 1995. Activation of virus-specific major histocompatibility complex class II-restricted CD8+ cytotoxic T cells in CD4-deficient mice. Eur J Immunol 25(4):1109-12. [PubMed: 7737281]  [MGI Ref ID J:112983]

Hida S; Ogasawara K; Sato K; Abe M; Takayanagi H; Yokochi T; Sato T; Hirose S; Shirai T; Taki S; Taniguchi T. 2000. CD8(+) T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-alpha/beta signaling Immunity 13(5):643-55. [PubMed: 11114377]  [MGI Ref ID J:66034]

Hofmann U; Beyersdorf N; Weirather J; Podolskaya A; Bauersachs J; Ertl G; Kerkau T; Frantz S. 2012. Activation of CD4+ T lymphocytes improves wound healing and survival after experimental myocardial infarction in mice. Circulation 125(13):1652-63. [PubMed: 22388323]  [MGI Ref ID J:198617]

Hornquist CE; Ekman L; Grdic KD; Schon K; Lycke NY. 1995. Paradoxical IgA immunity in CD4-deficient mice. Lack of cholera toxin-specific protective immunity despite normal gut mucosal IgA differentiation. J Immunol 155(6):2877-87. [PubMed: 7673704]  [MGI Ref ID J:110845]

Howe CL; Adelson JD; Rodriguez M. 2007. Absence of perforin expression confers axonal protection despite demyelination. Neurobiol Dis 25(2):354-9. [PubMed: 17112732]  [MGI Ref ID J:119009]

Huber SA; Sakkinen P; David C; Newell MK; Tracy RP. 2001. T helper-cell phenotype regulates atherosclerosis in mice under conditions of mild hypercholesterolemia. Circulation 103(21):2610-6. [PubMed: 11382732]  [MGI Ref ID J:133189]

Hung K; Hayashi R; Lafond-Walker A; Lowenstein C; Pardoll D; Levitsky H. 1998. The central role of CD4(+) T cells in the antitumor immune response. J Exp Med 188(12):2357-68. [PubMed: 9858522]  [MGI Ref ID J:51677]

Ingram JT; Yi JS; Zajac AJ. 2011. Exhausted CD8 T cells downregulate the IL-18 receptor and become unresponsive to inflammatory cytokines and bacterial co-infections. PLoS Pathog 7(9):e1002273. [PubMed: 21980291]  [MGI Ref ID J:183336]

Intlekofer AM; Takemoto N; Kao C; Banerjee A; Schambach F; Northrop JK; Shen H; Wherry EJ; Reiner SL. 2007. Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells. J Exp Med 204(9):2015-21. [PubMed: 17698591]  [MGI Ref ID J:126087]

Ip CW; Kroner A; Bendszus M; Leder C; Kobsar I; Fischer S; Wiendl H; Nave KA; Martini R. 2006. Immune cells contribute to myelin degeneration and axonopathic changes in mice overexpressing proteolipid protein in oligodendrocytes. J Neurosci 26(31):8206-16. [PubMed: 16885234]  [MGI Ref ID J:111136]

Joetham A; Takeda K; Taube C; Miyahara N; Kanehiro A; Dakhama A; Gelfand EW. 2005. Airway hyperresponsiveness in the absence of CD4+ T cells after primary but not secondary challenge. Am J Respir Cell Mol Biol 33(1):89-96. [PubMed: 15845865]  [MGI Ref ID J:110969]

Kamperschroer C; Roberts DM; Zhang Y; Weng NP; Swain SL. 2008. SAP enables T cells to help B cells by a mechanism distinct from Th cell programming or CD40 ligand regulation. J Immunol 181(6):3994-4003. [PubMed: 18768854]  [MGI Ref ID J:139100]

Kang TW; Yevsa T; Woller N; Hoenicke L; Wuestefeld T; Dauch D; Hohmeyer A; Gereke M; Rudalska R; Potapova A; Iken M; Vucur M; Weiss S; Heikenwalder M; Khan S; Gil J; Bruder D; Manns M; Schirmacher P; Tacke F; Ott M; Luedde T; Longerich T; Kubicka S; Zender L. 2011. Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature 479(7374):547-51. [PubMed: 22080947]  [MGI Ref ID J:179823]

Kerkar SP; Goldszmid RS; Muranski P; Chinnasamy D; Yu Z; Reger RN; Leonardi AJ; Morgan RA; Wang E; Marincola FM; Trinchieri G; Rosenberg SA; Restifo NP. 2011. IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors. J Clin Invest 121(12):4746-57. [PubMed: 22056381]  [MGI Ref ID J:184027]

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Tyznik AJ; Sun JC; Bevan MJ. 2004. The CD8 population in CD4-deficient mice is heavily contaminated with MHC class II-restricted T cells. J Exp Med 199(4):559-65. [PubMed: 14769854]  [MGI Ref ID J:90469]

Tzelepis F; Persechini PM; Rodrigues MM. 2007. Modulation of CD4+ T cell-dependent specific cytotoxic CD8+ T cells differentiation and proliferation by the timing of increase in the pathogen load. PLoS ONE 2(4):e393. [PubMed: 17460760]  [MGI Ref ID J:129273]

Van Laethem F; Sarafova SD; Park JH; Tai X; Pobezinsky L; Guinter TI; Adoro S; Adams A; Sharrow SO; Feigenbaum L; Singer A. 2007. Deletion of CD4 and CD8 Coreceptors Permits Generation of alphabetaT Cells that Recognize Antigens Independently of the MHC. Immunity 27(5):735-50. [PubMed: 18023370]  [MGI Ref ID J:127623]

Van Laethem F; Tikhonova AN; Pobezinsky LA; Tai X; Kimura MY; Le Saout C; Guinter TI; Adams A; Sharrow SO; Bernhardt G; Feigenbaum L; Singer A. 2013. Lck availability during thymic selection determines the recognition specificity of the T cell repertoire. Cell 154(6):1326-41. [PubMed: 24034254]  [MGI Ref ID J:204615]

VanCott JL; McNeal MM; Flint J; Bailey SA; Choi AH; Ward RL. 2001. Role for T cell-independent B cell activity in the resolution of primary rotavirus infection in mice. Eur J Immunol 31(11):3380-7. [PubMed: 11745356]  [MGI Ref ID J:72616]

VanLith ML; Kohlgraf KG; Sivinski CL; Tempero RM; Hollingsworth MA. 2002. MUC1-specific anti-tumor responses: molecular requirements for CD4-mediated responses. Int Immunol 14(8):873-82. [PubMed: 12147624]  [MGI Ref ID J:113544]

Vu MD; Amanullah F; Li Y; Demirci G; Sayegh MH; Li XC. 2004. Different costimulatory and growth factor requirements for CD4+ and CD8+ T cell-mediated rejection. J Immunol 173(1):214-21. [PubMed: 15210777]  [MGI Ref ID J:90930]

Wallace VA; Kondo S; Kono T; Xing Z; Timms E; Furlonger C; Keystone E; Gauldie J; Sauder DN; Mak TW; Paige CJ. 1994. A role for CD4+ T cells in the pathogenesis of skin fibrosis in tight skin mice. Eur J Immunol 24(6):1463-6. [PubMed: 7911425]  [MGI Ref ID J:18913]

Wallace VA; Penninger J; Mak TW. 1994. T-Cell development in CD4, CD8, and p56(lck) Gene-Targeted mice.. In: Transgenesis and Targeted Mutagenesis in Immunology. Academic Press, Inc..  [MGI Ref ID J:21662]

Wallace VA; Rahemtulla A; Timms E; Penninger J; Mak TW. 1992. CD4 expression is differentially required for deletion of MLS-1a-reactive T cells. J Exp Med 176(5):1459-63. [PubMed: 1402689]  [MGI Ref ID J:110753]

Walton SM; Torti N; Mandaric S; Oxenius A. 2011. T-cell help permits memory CD8(+) T-cell inflation during cytomegalovirus latency. Eur J Immunol 41(8):2248-59. [PubMed: 21590767]  [MGI Ref ID J:176830]

Wang B; Fujisawa H; Zhuang L; Freed I; Howell BG; Shahid S; Shivji GM; Mak TW; Sauder DN. 2000. CD4(+) Th1 and CD8(+) type 1 cytotoxic T cells both play a crucial role in the full development of contact hypersensitivity J Immunol 165(12):6783-90. [PubMed: 11120799]  [MGI Ref ID J:66170]

Wang C; Hino A; Yoshimoto T; Nagase H; Kato T; Hirokawa K; Matsuzawa A; Nariuchi H. 2000. Impaired delayed-type hypersensitivity response in mutant mice secreting soluble CD4 without expression of membrane-bound CD4 Immunology 100(3):309-16. [PubMed: 10929052]  [MGI Ref ID J:63431]

Wang T; Chen L; Ahmed E; Ma L; Yin D; Zhou P; Shen J; Xu H; Wang CR; Alegre ML; Chong AS. 2008. Prevention of allograft tolerance by bacterial infection with Listeria monocytogenes. J Immunol 180(9):5991-9. [PubMed: 18424719]  [MGI Ref ID J:134678]

Wen T; Trumper L; Fung-Leung W; Rahemtulla A; Klein E; Klein G; Mak TW. 1998. Requirement of the CD8+ or CD4+ T lymphocyte subsets for the rejection of lymphoma and fibrosarcoma grafts studied in gene knockout hosts. Immunol Lett 61(2-3):187-90. [PubMed: 9657273]  [MGI Ref ID J:47925]

Weng X; Priceputu E; Chrobak P; Poudrier J; Kay DG; Hanna Z; Mak TW; Jolicoeur P. 2004. CD4+ T cells from CD4C/HIVNef transgenic mice show enhanced activation in vivo with impaired proliferation in vitro but are dispensable for the development of a severe AIDS-like organ disease. J Virol 78(10):5244-57. [PubMed: 15113906]  [MGI Ref ID J:89588]

Wiesel M; Joller N; Ehlert AK; Crouse J; Sporri R; Bachmann MF; Oxenius A. 2010. Th cells act via two synergistic pathways to promote antiviral CD8+ T cell responses. J Immunol 185(9):5188-97. [PubMed: 20881183]  [MGI Ref ID J:165190]

Wiesel M; Kratky W; Oxenius A. 2011. Type I IFN substitutes for T cell help during viral infections. J Immunol 186(2):754-63. [PubMed: 21160039]  [MGI Ref ID J:168770]

Willimsky G; Schmidt K; Loddenkemper C; Gellermann J; Blankenstein T. 2013. Virus-induced hepatocellular carcinomas cause antigen-specific local tolerance. J Clin Invest 123(3):1032-43. [PubMed: 23454765]  [MGI Ref ID J:196378]

Wong WF; Kohu K; Nakamura A; Ebina M; Kikuchi T; Tazawa R; Tanaka K; Kon S; Funaki T; Sugahara-Tobinai A; Looi CY; Endo S; Funayama R; Kurokawa M; Habu S; Ishii N; Fukumoto M; Nakata K; Takai T; Satake M. 2012. Runx1 deficiency in CD4+ T cells causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells. J Immunol 188(11):5408-20. [PubMed: 22551552]  [MGI Ref ID J:188720]

Xiang J; Huang H; Liu Y. 2005. A new dynamic model of CD8+ T effector cell responses via CD4+ T helper-antigen-presenting cells. J Immunol 174(12):7497-505. [PubMed: 15944248]  [MGI Ref ID J:100792]

Xin H; Kikuchi T; Andarini S; Ohkouchi S; Suzuki T; Nukiwa T; Hagiwara K; Honjo T; Saijo Y. 2005. Antitumor immune response by CX3CL1 fractalkine gene transfer depends on both NK and T cells. Eur J Immunol 35(5):1371-80. [PubMed: 15789339]  [MGI Ref ID J:97809]

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Yi JS; Du M; Zajac AJ. 2009. A vital role for interleukin-21 in the control of a chronic viral infection. Science 324(5934):1572-6. [PubMed: 19443735]  [MGI Ref ID J:150002]

Yi JS; Ingram JT; Zajac AJ. 2010. IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infection. J Immunol 185(8):4835-45. [PubMed: 20844201]  [MGI Ref ID J:164735]

Yuan X; Ansari MJ; D'Addio F; Paez-Cortez J; Schmitt I; Donnarumma M; Boenisch O; Zhao X; Popoola J; Clarkson MR; Yagita H; Akiba H; Freeman GJ; Iacomini J; Turka LA; Glimcher LH; Sayegh MH. 2009. Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells. Proc Natl Acad Sci U S A 106(26):10734-9. [PubMed: 19528638]  [MGI Ref ID J:150842]

Yusuf N; Nasti TH; Katiyar SK; Jacobs MK; Seibert MD; Ginsburg AC; Timares L; Xu H; Elmets CA. 2008. Antagonistic roles of CD4+ and CD8+ T-cells in 7,12-dimethylbenz(a)anthracene cutaneous carcinogenesis. Cancer Res 68(10):3924-30. [PubMed: 18483278]  [MGI Ref ID J:135019]

Zhang G; Peng Y; Schoenlaub L; Elliott A; Mitchell W; Zhang Y. 2013. Formalin-inactivated Coxiella burnetii phase I vaccine-induced protection depends on B cells to produce protective IgM and IgG. Infect Immun 81(6):2112-22. [PubMed: 23545296]  [MGI Ref ID J:199523]

Zhang GX; Xiao BG; Bakhiet M; van der Meide P; Wigzell H; Link H; Olsson T. 1996. Both CD4+ and CD8+ T cells are essential to induce experimental autoimmune myasthenia gravis. J Exp Med 184(2):349-56. [PubMed: 8760788]  [MGI Ref ID J:110750]

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Zhu Y; Bao L; Zhu S; Chen Z; van der Meide P; Nennesmo I; Winblad B; Ljunggren HG; Zhu J. 2002. CD4 and CD8 T cells, but not B cells, are critical to the control of murine experimental autoimmune neuritis. Exp Neurol 177(1):314-20. [PubMed: 12429233]  [MGI Ref ID J:118779]

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Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, these mice can be bred as homozygotes.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2140.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2782.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   001026 BALB/cByJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice
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JAX® Services
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Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

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phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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