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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Congenic; Major Histocompatibility Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Background Strain 129S1/SvImJ Donor Strain NOD/ShiLtJ H2 Haplotype g7 Generation N10F10 (13-APR-09) Donating Investigator Edward Leiter, The Jackson Laboratory Appearance
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Related Genotype: A/ADescription
129S1.NOD-H2g7 congenic mice are viable, fertile, normal in size, do not display any gross physical or behavioral abnormalities and are diabetes free. Because targeted mutations frequently are made using 129 ES cells, this strain may be useful for identifying Idds in 129 strains.Development
Idd1, linked to the major histocompatibility locus, is located on Chr 17. This 129S1 congenic strain, carrying a defined genomic segment of Chr 17 from NOD/LtJ that includes Idd1 (19.5cM) and H2g7 (23cM), was produced by mating mice from 129S1/SvImJ (Stock No. 002448) to NOD/ShiLtJ (Stock No. 001976) for seven generations (N7) with selection for H2g7 by FACS analysis at each generation. Sibs were intercrossed to generate mice homozygous for the NOD genomic segment (5.3cM), D17Mit175 (31571388-31571496) through H2g7 (23cM). In addition, the strain also carries genomic markers D17Mit16 (33207435-33207557), D17Mit21 (33851425-33851562) and D17Mit34 (34352109-34352255) derived from NOD/ShiLtJ origin, while D17Mit213 (16319811-16319934) and D17Mit24 (37090217-37090359) are from 129S1/SvImJ. Genome scans using SNPS markers indicate that the rest of the genome is derived from 129S1/SvImJ.
Control Information
| Control | ||
|---|---|---|
| 002448 129S1/SvImJ | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of H2
View Strains carrying other alleles of H2 (127 strains)
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
Diabetes and Obesity Research
Type 1 Diabetes (IDDM) Analysis Strains
NOD/ShiLtJ MHC Congenics
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Genes & Alleles
Gene & Allele Information
| Gene Symbol and Name | H2, histocompatibility-2, MHC | ||
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| Chromosome | 17 | ||
| Gene Common Name(s) | H-2; MHC-II; | ||
| Gene Symbol and Name | D17Mit175, DNA segment, Chr 17, Massachusetts Institute of Technology 175 | ||
| Chromosome | 17 | ||
| Gene Symbol and Name | Idd1, insulin dependent diabetes susceptibility 1 | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | Idd-1; | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Leiter EH; Reifsnyder PC; Wallace R; Li R; King B; Churchill GC. 2009. NOD x 129.H2g7 Backcross Delineates 129S1/SvImJ-Derived Genomic Regions Modulating Type 1 Diabetes (T1D) Development In Mice. Diabetes :. [PubMed: 19336673] [MGI Ref ID J:147560]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX11
Colony Maintenance
Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $54.00 Female or Male Homozygous
Pairs /Price (US dollars $) Pair Genotype $108.00 Homozygous
Additional Supply Details
| Pricing for International shipping destinations |
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $70.20 Female or Male Homozygous
Pairs /Price (US dollars $) Pair Genotype $140.40 Homozygous
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| 002448 129S1/SvImJ | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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