Strain Name:

B6.C-H2-Kbm1/ByBir-Gusbmps/BrkJ

Stock Number:

006559

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Availability:

Cryopreserved - Ready for recovery

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6.C-H2bm1/ByBir-Gusbmps/BrkJ    (Changed: 24-APR-09 )
Type Chemically Induced Mutation; Coisogenic; Congenic; Major Histocompatibility Congenic; Spontaneous Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
GenerationF?+30pN1
Generation Definitions

Description
Mice homozygous for the Gusbmps allele exhibit skeletal dysplasia as well as cognitive, hearing and visual deficits. Lifespan of the homozygotes is approximately six months. Homozygotes lack the lysomal enzyme, beta-glucoronidase, and, as a result, glycosaminoglycans accumulate in tissues throughout the body. Female homozygotes rarely conceive and do not lactate. This strain is a model for the human lysomal storage disease, mucopolysaccharidosis type VII.

Development
The Gusbmps mutation arose spontaneously on B6.C-H2bm1/By in 1976 (Birkenmeier et al., 1989).

Related Strains

View Strains carrying   Gusbmps     (7 strains)

Strains carrying   H2-Kbm1 allele
000368   B6.C-H2-Kbm1/By
000256   B6.C-H2-Kbm1/ByBir-Gusbmps/J
001060   B6.C-H2-Kbm1/ByJ
006558   B6.Cg-H2-Kbm1 Tg(GUSB)4Sly/SndsJ
002432   B6J x B6.C-H2-Kbm1/ByJ-Cdh23v-J/J
View Strains carrying   H2-Kbm1     (5 strains)

Strains carrying other alleles of Gusb
005643   B6.129X-Gusbtm1Sly/J
005644   B6.129X-Gusbtm3Sly/J
001603   B6.A-Gusba/J
001598   B6.C3-Gusbh/J
006557   B6.C3-Gusbmps-2J/BrkJ
001599   B6.CAST-Gusbcs/J
001604   B6.Cg-Ces1cb Ces1eh Gusbh/J
001605   B6.Cg-Gusbw12/CvJ
001608   B6.Cg-Gusbw26/CvJ
001602   B6.MOR-Gusbw5/CvJ
001597   B6.PAC-Gusbn/J
003525   C3H/HeOuJ-Gusbmps-2J/BrkJ
005322   C57BL/6J-Gusbmps-3J/J
View Strains carrying other alleles of Gusb     (13 strains)

View Strains carrying other alleles of H2-K     (13 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
Mucopolysaccharidosis, Type VII; MPS7
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Gusbmps/Gusbmps

        involves: C57BL/6By
  • mortality/aging
  • premature death
    • death between 150 and 200 days   (MGI Ref ID J:13923)
  • adipose tissue phenotype
  • decreased white adipose tissue amount
    • absent, but normal brown fat amount   (MGI Ref ID J:13923)
  • craniofacial phenotype
  • short snout   (MGI Ref ID J:13923)
  • endocrine/exocrine gland phenotype
  • abnormal lactation
    • inadequate lactation to nurture pups   (MGI Ref ID J:13923)
  • growth/size/body phenotype
  • decreased body length   (MGI Ref ID J:13923)
  • disproportionate dwarf
  • short snout   (MGI Ref ID J:13923)
  • homeostasis/metabolism phenotype
  • decreased circulating cholesterol level
    • compared to littermate controls   (MGI Ref ID J:13923)
  • increased urine glycosaminoglycan level
    • increase in urinary glycosaminoglycan levels   (MGI Ref ID J:87155)
  • limbs/digits/tail phenotype
  • short limbs   (MGI Ref ID J:13923)
  • short tail   (MGI Ref ID J:13923)
  • reproductive system phenotype
  • male infertility
    • sterility not due to reproductive or gonadal tract dysmorphology or to sperm numbers, morphology, or motility   (MGI Ref ID J:13923)
  • skeleton phenotype
  • abnormal skeleton morphology
    • mutant bones shorter and thicker than littermate controls, but contain same amount of mineralization   (MGI Ref ID J:13923)
  • renal/urinary system phenotype
  • increased urine glycosaminoglycan level
    • increase in urinary glycosaminoglycan levels   (MGI Ref ID J:87155)
  • integument phenotype
  • abnormal lactation
    • inadequate lactation to nurture pups   (MGI Ref ID J:13923)

Gusbmps/Gusbmps

        B6.C-H2-Kbm1/ByBir-Gusbmps/J
  • mortality/aging
  • premature death
    • males live an average of 170 days and females an average of 141 days; only 10 live longer than 241 days   (MGI Ref ID J:9705)
  • growth/size/body phenotype
  • disproportionate dwarf   (MGI Ref ID J:9705)
  • short snout
    • pug-nosed appearance   (MGI Ref ID J:9705)
  • craniofacial phenotype
  • short snout
    • pug-nosed appearance   (MGI Ref ID J:9705)
  • small nasal bone
    • nasal bones are reduced in size, resulting in a pug-nosed appearance   (MGI Ref ID J:9705)
  • cellular phenotype
  • abnormal lysosome morphology
    • vacuolar storage in many tissues (lysosomal storage disorder)   (MGI Ref ID J:9705)
  • endocrine/exocrine gland phenotype
  • abnormal lactation
    • females exhibit insufficient lactation to nurture pups   (MGI Ref ID J:9705)
  • limbs/digits/tail phenotype
  • short limbs
    • shorter, stubby limbs   (MGI Ref ID J:9705)
  • short tail   (MGI Ref ID J:9705)
  • thick tail   (MGI Ref ID J:9705)
  • reproductive system phenotype
  • male infertility
    • males are sterile, however gonadal and reproductive tract morphology and sperm numbers, morphology, and motility appear normal   (MGI Ref ID J:9705)
  • skeleton phenotype
  • abnormal skeleton morphology
    • severe skeletal deformities   (MGI Ref ID J:9705)
    • small nasal bone
      • nasal bones are reduced in size, resulting in a pug-nosed appearance   (MGI Ref ID J:9705)
  • integument phenotype
  • abnormal lactation
    • females exhibit insufficient lactation to nurture pups   (MGI Ref ID J:9705)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Developmental Biology Research
Growth Defects
      Growth Defects (homozygous)

Metabolism Research

Neurobiology Research
Behavioral and Learning Defects

Sensorineural Research

Gusbmps related

Developmental Biology Research
Growth Defects
      Growth Defects (homozygous)
Skeletal Defects

Metabolism Research

Neurobiology Research
Behavioral and Learning Defects

Sensorineural Research

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Gusbmps
Allele Name beta glucuronidase, mucopolysaccharidosis VII
Allele Type Spontaneous
Common Name(s) Gus-b; MPS VII; asd; gusmps;
Mutation Made By Brian Soper,   The Jackson Laboratory
Strain of OriginB6.C-H2-Kbm1/By
Gene Symbol and Name Gusb, glucuronidase, beta
Chromosome 5
Gene Common Name(s) AI747421; Ac2-223; BG; Gur; Gus; Gus-r; Gus-s; Gus-t; Gus-u; Gut; MPS7; adipose storage deficiency; asd; beta-glucuronidase regulator; beta-glucuronidase structural; beta-glucuronidase systemic regulator; beta-glucuronidase temporal; expressed sequence AI747421; g;
Molecular Note A 1-bp deletion creates a frameshift mutation within exon 10, which introduces a premature stop codon at codon 497. [MGI Ref ID J:13207]
 
Allele Symbol H2-Kbm1
Allele Name b haplotype mutation 1
Allele Type Spontaneous
Common Name(s) H(z1); H-2ba; H-2bm1; Kbm1; bm1;
Strain of OriginBALB/cBy
Gene Symbol and Name H2-K, histocompatibility 2, K region
Chromosome 17
General Note Genbank ID for this allele: X56624
Molecular Note The bm1 mutation contains 7 nucleotide differences resulting in amino acid substitutions at codon 152 (glutamate to alanine), codon 155 (arginine to tyrosine) and codon 156 (leucine to tyrosine). [MGI Ref ID J:109263] [MGI Ref ID J:109268] [MGI Ref ID J:109270] [MGI Ref ID J:164061] [MGI Ref ID J:35731]

Genotyping

Genotyping Information

Genotyping Protocols

Gusbmps, Pyrosequencing
Gusbmps, Restriction Enzyme Digest


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Gusbmps related

Alfaro MP; Pagni M; Vincent A; Atkinson J; Hill MF; Cates J; Davidson JM; Rottman J; Lee E; Young PP. 2008. The Wnt modulator sFRP2 enhances mesenchymal stem cell engraftment, granulation tissue formation and myocardial repair. Proc Natl Acad Sci U S A 105(47):18366-71. [PubMed: 19017790]  [MGI Ref ID J:142215]

Baldo G; Wu S; Howe RA; Ramamoothy M; Knutsen RH; Fang J; Mecham RP; Liu Y; Wu X; Atkinson JP; Ponder KP. 2011. Pathogenesis of aortic dilatation in mucopolysaccharidosis VII mice may involve complement activation. Mol Genet Metab 104(4):608-19. [PubMed: 21944884]  [MGI Ref ID J:178881]

Barker JE; Deveau S; Lessard M; Hamblen N; Vogler C; Levy B. 2001. In Utero Fetal Liver Cell Transplantation without Toxic Irradiation Alleviates Lysosomal Storage in Mice with Mucopolysaccharidosis Type VII. Blood Cells Mol Dis 27(5):861-73. [PubMed: 11783949]  [MGI Ref ID J:72147]

Bastedo L; Sands MS; Lambert DT; Pisa MA; Birkenmeier E; Chang PL. 1994. Behavioral consequences of bone marrow transplantation in the treatment of murine mucopolysaccharidosis type VII. J Clin Invest 94(3):1180-6. [PubMed: 8083358]  [MGI Ref ID J:20455]

Beamer WG; Coleman DL. 1982. [Adipose storage deficiency (asd)]. Mouse News Lett 67:21.  [MGI Ref ID J:13923]

Berry CL; Vogler C; Galvin NJ; Birkenmeier EH; Sly WS. 1994. Pathology of the ear in murine mucopolysaccharidosis type VII. Morphologic correlates of hearing loss. Lab Invest 71(3):438-45. [PubMed: 7933993]  [MGI Ref ID J:20883]

Birkenmeier EH; Barker JE; Vogler CA; Kyle JW; Sly WS; Gwynn B; Levy B; Pegors C. 1991. Increased life span and correction of metabolic defects in murine mucopolysaccharidosis type VII after syngeneic bone marrow transplantation. Blood 78(11):3081-92. [PubMed: 1954394]  [MGI Ref ID J:1655]

Birkenmeier EH; Davisson MT; Beamer WG; Ganschow RE; Vogler CA; Gwynn B; Lyford KA; Maltais LM; Wawrzyniak CJ. 1989. Murine mucopolysaccharidosis type VII. Characterization of a mouse with beta-glucuronidase deficiency. J Clin Invest 83(4):1258-6. [PubMed: 2495302]  [MGI Ref ID J:9705]

Casal ML; Wolfe JH. 2000. Mucopolysaccharidosis type VII in the developing mouse fetus Pediatr Res 47(6):750-6. [PubMed: 10832732]  [MGI Ref ID J:63383]

Casal ML; Wolfe JH. 1998. Variant clinical course of mucopolysaccharidosis type VII in two groups of mice carrying the same mutation. Lab Invest 78(12):1575-81. [PubMed: 9881957]  [MGI Ref ID J:51808]

Chang PL; Lambert DT; Pisa MA. 1993. Behavioural abnormalities in a murine model of a human lysosomal storage disease. Neuroreport 4(5):507-10. [PubMed: 8513128]  [MGI Ref ID J:15184]

Chen YH; Chang M; Davidson BL. 2009. Molecular signatures of disease brain endothelia provide new sites for CNS-directed enzyme therapy. Nat Med 15(10):1215-8. [PubMed: 19749771]  [MGI Ref ID J:154308]

Daly TM; Vogler C; Levy B; Haskins ME; Sands MS. 1999. Neonatal gene transfer leads to widespread correction of pathology in a murine model of lysosomal storage disease. Proc Natl Acad Sci U S A 96(5):2296-300. [PubMed: 10051635]  [MGI Ref ID J:53359]

Donsante A; Vogler C; Muzyczka N; Crawford JM; Barker J; Flotte T; Campbell-Thompson M; Daly T; Sands MS. 2001. Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors. Gene Ther 8(17):1343-6. [PubMed: 11571571]  [MGI Ref ID J:71706]

Faust JR; Rodman JS; Daniel PF; Dice JF; Bronson RT. 1994. Two related proteolipids and dolichol-linked oligosaccharides accumulate in motor neuron degeneration mice (mnd/mnd), a model for neuronal ceroid lipofuscinosis. J Biol Chem 269(13):10150-5. [PubMed: 8144516]  [MGI Ref ID J:17522]

Freeman BJ; Roberts MS; Vogler CA; Nicholes A; Hofling AA; Sands MS. 1999. Behavior and therapeutic efficacy of beta-glucuronidase-positive mononuclear phagocytes in a murine model of mucopolysaccharidosis type VII. Blood 94(6):2142-50. [PubMed: 10477745]  [MGI Ref ID J:57636]

Frischmeyer-Guerrerio PA; Montgomery RA; Warren DS; Cooke SK; Lutz J; Sonnenday CJ; Guerrerio AL; Dietz HC. 2011. Perturbation of thymocyte development in nonsense-mediated decay (NMD)-deficient mice. Proc Natl Acad Sci U S A 108(26):10638-43. [PubMed: 21670277]  [MGI Ref ID J:173551]

Ghodsi A; Stein C; Derksen T; Martins I; Anderson RD; Davidson BL. 1999. Systemic hyperosmolality improves beta-glucuronidase distribution and pathology in murine MPS VII brain following intraventricular gene transfer. Exp Neurol 160(1):109-16. [PubMed: 10630195]  [MGI Ref ID J:58538]

Hofling AA; Vogler C; Creer MH; Sands MS. 2003. Engraftment of human CD34+ cells leads to widespread distribution of donor-derived cells and correction of tissue pathology in a novel murine xenotransplantation model of lysosomal storage disease. Blood 101(5):2054-63. [PubMed: 12406886]  [MGI Ref ID J:109848]

Kyle JW; Birkenmeier EH; Gwynn B; Vogler C; Hoppe PC; Hoffmann JW; Sly WS. 1990. Correction of murine mucopolysaccharidosis VII by a human beta-glucuronidase transgene. Proc Natl Acad Sci U S A 87(10):3914-8. [PubMed: 2111021]  [MGI Ref ID J:21256]

Li B; Sharpe EE; Maupin AB; Teleron AA; Pyle AL; Carmeliet P; Young PP. 2006. VEGF and PlGF promote adult vasculogenesis by enhancing EPC recruitment and vessel formation at the site of tumor neovascularization. FASEB J 20(9):1495-7. [PubMed: 16754748]  [MGI Ref ID J:111344]

Meng XL; Shen JS; Kawagoe S; Ohashi T; Brady RO; Eto Y. 2010. Induced pluripotent stem cells derived from mouse models of lysosomal storage disorders. Proc Natl Acad Sci U S A 107(17):7886-91. [PubMed: 20385825]  [MGI Ref ID J:159373]

Metcalf JA; Zhang Y; Hilton MJ; Long F; Ponder KP. 2009. Mechanism of shortened bones in mucopolysaccharidosis VII. Mol Genet Metab 97(3):202-11. [PubMed: 19375967]  [MGI Ref ID J:150606]

Monroy MA; Ross FP; Teitelbaum SL; Sands MS. 2002. Abnormal osteoclast morphology and bone remodeling in a murine model of a lysosomal storage disease. Bone 30(2):352-9. [PubMed: 11856642]  [MGI Ref ID J:109426]

Moullier P; Bohl D; Heard JM; Danos O. 1993. Correction of lysosomal storage in the liver and spleen of MPS VII mice by implantation of genetically modified skin fibroblasts [see comments] Nat Genet 4(2):154-9. [PubMed: 8348154]  [MGI Ref ID J:11889]

Niermann GL; Watson GL. 1999. Growth hormone and insulin-like growth factor-I enhance beta-glucuronidase gene activation by androgen in mouse kidney. Mol Cell Endocrinol 153(1-2):47-55. [PubMed: 10459853]  [MGI Ref ID J:56310]

O'Connor LH; Erway LC; Vogler CA; Sly WS; Nicholes A; Grubb J; Holmberg SW; Levy B; Sands MS. 1998. Enzyme replacement therapy for murine mucopolysaccharidosis type VII leads to improvements in behavior and auditory function. J Clin Invest 101(7):1394-400. [PubMed: 9525982]  [MGI Ref ID J:46825]

Ohashi T; Watabe K; Uehara K; Sly WS; Vogler C; Eto Y. 1997. Adenovirus-mediated gene transfer and expression of human beta-glucuronidase gene in the liver, spleen, and central nervous system in mucopolysaccharidosis type VII mice. Proc Natl Acad Sci U S A 94(4):1287-92. [PubMed: 9037045]  [MGI Ref ID J:38613]

Ohlemiller KK; Hennig AK; Lett JM; Heidbreder AF; Sands MS. 2002. Inner ear pathology in the mucopolysaccharidosis VII mouse. Hear Res 169(1-2):69-84. [PubMed: 12121741]  [MGI Ref ID J:108876]

Ohlemiller KK; Vogler CA; Roberts M; Galvin N; Sands MS. 2000. Retinal function is improved in a murine model of a lysosomal storage disease following bone marrow transplantation Exp Eye Res 71(5):469-81. [PubMed: 11040082]  [MGI Ref ID J:66030]

Parente MK; Rozen R; Cearley CN; Wolfe JH. 2012. Dysregulation of gene expression in a lysosomal storage disease varies between brain regions implicating unexpected mechanisms of neuropathology. PLoS One 7(3):e32419. [PubMed: 22403656]  [MGI Ref ID J:186852]

Poorthuis BJ; Romme AE; Willemsen R; Wagemaker G. 1994. Bone marrow transplantation has a significant effect on enzyme levels and storage of glycosaminoglycans in tissues and in isolated hepatocytes of mucopolysaccharidosis type VII mice. Pediatr Res 36(2):187-93. [PubMed: 7970933]  [MGI Ref ID J:22149]

Sands MS; Birkenmeier EH. 1993. A single-base-pair deletion in the beta-glucuronidase gene accounts for the phenotype of murine mucopolysaccharidosis type VII. Proc Natl Acad Sci U S A 90(14):6567-71. [PubMed: 8101990]  [MGI Ref ID J:13207]

Sands MS; Vogler C; Kyle JW; Grubb JH; Levy B; Galvin N; Sly WS; Birkenmeier EH. 1994. Enzyme replacement therapy for murine mucopolysaccharidosis type VII. J Clin Invest 93(6):2324-31. [PubMed: 8200966]  [MGI Ref ID J:19122]

Sato T; Ikeda M; Yotsumoto S; Shimada Y; Higuchi T; Kobayashi H; Fukuda T; Ohashi T; Suda T; Ohteki T. 2013. Novel interferon-based pre-transplantation conditioning in the treatment of a congenital metabolic disorder. Blood 121(16):3267-73. [PubMed: 23412092]  [MGI Ref ID J:196707]

Sferra TJ; Qu G; McNeely D; Rennard R; Clark KR; Lo WD; Johnson PR. 2000. Recombinant adeno-associated virus-mediated correction of lysosomal storage within the central nervous system of the adult mucopolysaccharidosis type VII mouse Hum Gene Ther 11(4):507-19. [PubMed: 10724030]  [MGI Ref ID J:61251]

Simonaro CM; Ge Y; Eliyahu E; He X; Jepsen KJ; Schuchman EH. 2010. Involvement of the Toll-like receptor 4 pathway and use of TNF-alpha antagonists for treatment of the mucopolysaccharidoses. Proc Natl Acad Sci U S A 107(1):222-7. [PubMed: 20018674]  [MGI Ref ID J:156466]

Skorupa AF; Fisher KJ; Wilson JM; Parente MK; Wolfe JH. 1999. Sustained production of beta-glucuronidase from localized sites after AAV vector gene transfer results in widespread distribution of enzyme and reversal of lysosomal storage lesions in a large volume of brain in mucopolysaccharidosis VII mice. Exp Neurol 160(1):17-27. [PubMed: 10630187]  [MGI Ref ID J:58536]

Sly WS; Vogler C; Grubb JH; Zhou M; Jiang J; Zhou XY; Tomatsu S; Bi Y; Snella EM. 2001. Active site mutant transgene confers tolerance to human beta -glucuronidase without affecting the phenotype of MPS VII mice. Proc Natl Acad Sci U S A 98(5):2205-10. [PubMed: 11226217]  [MGI Ref ID J:67876]

Snyder EY; Taylor RM; Wolfe JH. 1995. Neural progenitor cell engraftment corrects lysosomal storage throughout the MPS VII mouse brain. Nature 374(6520):367-70. [PubMed: 7885477]  [MGI Ref ID J:23926]

Soper BW; Duffy TM; Vogler CA; Barker JE. 1999. A genetically myeloablated MPS VII model detects the expansion and curative properties of as few as 100 enriched murine stem cells. Exp Hematol 27(11):1691-704. [PubMed: 10560917]  [MGI Ref ID J:58272]

Stein CS; Ghodsi A; Derksen T; Davidson BL. 1999. Systemic and central nervous system correction of lysosomal storage in mucopolysaccharidosis type VII mice. J Virol 73(4):3424-9. [PubMed: 10074197]  [MGI Ref ID J:53465]

Tomatsu S; Orii KO; Vogler C; Nakayama J; Levy B; Grubb JH; Gutierrez MA; Shim S; Yamaguchi S; Nishioka T; Montano AM; Noguchi A; Orii T; Kondo N; Sly WS. 2003. Mouse model of N-acetylgalactosamine-6-sulfate sulfatase deficiency (Galns-/-) produced by targeted disruption of the gene defective in Morquio A disease. Hum Mol Genet 12(24):3349-58. [PubMed: 14583446]  [MGI Ref ID J:87155]

Vogler C; Sands M; Higgins A; Levy B; Grubb J; Birkenmeier EH; Sly WS. 1993. Enzyme replacement with recombinant beta-glucuronidase in the newborn mucopolysaccharidosis type VII mouse. Pediatr Res 34(6):837-40. [PubMed: 8108204]  [MGI Ref ID J:22453]

Wolfe JH; Deshmane SL; Fraser NW. 1992. Herpesvirus vector gene transfer and expression of beta-glucuronidase in the central nervous system of MPS VII mice. Nat Genet 1(5):379-84. [PubMed: 1338772]  [MGI Ref ID J:1832]

Woloszynek JC; Coleman T; Semenkovich CF; Sands MS. 2007. Lysosomal dysfunction results in altered energy balance. J Biol Chem 282(49):35765-71. [PubMed: 17911106]  [MGI Ref ID J:129210]

Woloszynek JC; Roberts M; Coleman T; Vogler C; Sly W; Semenkovich CF; Sands MS. 2004. Numerous transcriptional alterations in liver persist after short-term enzyme-replacement therapy in a murine model of mucopolysaccharidosis type VII. Biochem J 379(Pt 2):461-9. [PubMed: 14705966]  [MGI Ref ID J:88886]

H2-Kbm1 related

Agenes F; Dangy JP; Kirberg J. 2008. T cell receptor contact to restricting MHC molecules is a prerequisite for peripheral interclonal T cell competition. J Exp Med 205(12):2735-43. [PubMed: 19015305]  [MGI Ref ID J:141380]

Allison J; Stephens LA; Kay TW; Kurts C; Heath WR; Miller JF; Krummel MF. 1998. The threshold for autoimmune T cell killing is influenced by B7-1. Eur J Immunol 28(3):949-60. [PubMed: 9541590]  [MGI Ref ID J:134587]

Bailey DW; Snell GD; Cherry M. 1971. Complementation and Serolgical Analysis of an H-2 Mutant. In: Proc Symp Immunogenetics of the H-2 System, Liblice-Prague 1970. , Karger, Basel.  [MGI Ref ID J:164063]

Barouch-Bentov R; Lemmens EE; Hu J; Janssen EM; Droin NM; Song J; Schoenberger SP; Altman A. 2005. Protein kinase C-theta is an early survival factor required for differentiation of effector CD8+ T cells. J Immunol 175(8):5126-34. [PubMed: 16210616]  [MGI Ref ID J:119122]

Behrens GM; Li M; Davey GM; Allison J; Flavell RA; Carbone FR; Heath WR. 2004. Helper requirements for generation of effector CTL to islet beta cell antigens. J Immunol 172(9):5420-6. [PubMed: 15100283]  [MGI Ref ID J:89639]

Benedict CA; Loewendorf A; Garcia Z; Blazar BR; Janssen EM. 2008. Dendritic Cell Programming by Cytomegalovirus Stunts Naive T Cell Responses via the PD-L1/PD-1 Pathway. J Immunol 180(7):4836-47. [PubMed: 18354207]  [MGI Ref ID J:133375]

Blazar BR; Carreno BM; Panoskaltsis-Mortari A; Carter L; Iwai Y; Yagita H; Nishimura H; Taylor PA. 2003. Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism. J Immunol 171(3):1272-7. [PubMed: 12874215]  [MGI Ref ID J:120213]

Bluestone JA; McKenzie IF; Melvold RW; Ozato K; Sandrin MS; Sharrow SO; Sachs DH. 1984. Serological analysis of H-2 mutations using monoclonal antibodies. J Immunogenet 11(3-4):197-207. [PubMed: 6084033]  [MGI Ref ID J:98121]

Boenisch O; D'Addio F; Watanabe T; Elyaman W; Magee CN; Yeung MY; Padera RF; Rodig SJ; Murayama T; Tanaka K; Yuan X; Ueno T; Jurisch A; Mfarrej B; Akiba H; Yagita H; Najafian N. 2010. TIM-3: a novel regulatory molecule of alloimmune activation. J Immunol 185(10):5806-19. [PubMed: 20956339]  [MGI Ref ID J:165781]

Bolinger B; Krebs P; Tian Y; Engeler D; Scandella E; Miller S; Palmer DC; Restifo NP; Clavien PA; Ludewig B. 2008. Immunologic ignorance of vascular endothelial cells expressing minor histocompatibility antigen. Blood 111(9):4588-95. [PubMed: 18195091]  [MGI Ref ID J:134363]

Brown GR; Thiele DL. 2000. Enhancement of MHC class I-stimulated alloresponses by TNF/TNF receptor (TNFR)1 interactions and of MHC class II-stimulated alloresponses by TNF/TNFR2 interactions Eur J Immunol 30(10):2900-7. [PubMed: 11069072]  [MGI Ref ID J:65234]

Brown RE; Schellinck HM; Jagosh J. 1998. Behavioural studies of MHC-congenic mice. Genetica 104(3):249-57. [PubMed: 10386391]  [MGI Ref ID J:55290]

Carroll LS; Penn DJ; Potts WK. 2002. Discrimination of MHC-derived odors by untrained mice is consistent with divergence in peptide-binding region residues. Proc Natl Acad Sci U S A 99(4):2187-92. [PubMed: 11842193]  [MGI Ref ID J:74764]

Chen YH; Chang M; Davidson BL. 2009. Molecular signatures of disease brain endothelia provide new sites for CNS-directed enzyme therapy. Nat Med 15(10):1215-8. [PubMed: 19749771]  [MGI Ref ID J:154308]

Deguine J; Lee BL; Newman ZR; Barton GM. 2013. No antigen-presentation defect in Unc93b1(3d/3d) (3d) mice. Nat Immunol 14(11):1101-2. [PubMed: 24145778]  [MGI Ref ID J:208727]

Drutman SB; Trombetta ES. 2010. Dendritic cells continue to capture and present antigens after maturation in vivo. J Immunol 185(4):2140-6. [PubMed: 20644175]  [MGI Ref ID J:162616]

Dyer CM; Zhan Y; Brady JL; Carbone FR; Smyth MJ; Lew AM. 2004. Unexpectedly, induction of cytotoxic T lymphocytes enhances the humoral response after DNA immunization. Blood 103(8):3073-5. [PubMed: 15070687]  [MGI Ref ID J:115473]

El-Hayek JM; Rogers TE; Brown GR. 2005. The role of TNF in hepatic histopathological manifestations and hepatic CD8+ T cell alloresponses in murine MHC class I disparate GVHD. J Leukoc Biol 78(4):1001-7. [PubMed: 16081594]  [MGI Ref ID J:101534]

Enouz S; Carrie L; Merkler D; Bevan MJ; Zehn D. 2012. Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection. J Exp Med 209(10):1769-79. [PubMed: 22987800]  [MGI Ref ID J:191273]

Erlebacher A; Vencato D; Price KA; Zhang D; Glimcher LH. 2007. Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus. J Clin Invest 117(5):1399-411. [PubMed: 17446933]  [MGI Ref ID J:122071]

Ford MS; Zhang ZX; Chen W; Zhang L. 2006. Double-negative T regulatory cells can develop outside the thymus and do not mature from CD8+ T cell precursors. J Immunol 177(5):2803-9. [PubMed: 16920915]  [MGI Ref ID J:139556]

Frischmeyer-Guerrerio PA; Montgomery RA; Warren DS; Cooke SK; Lutz J; Sonnenday CJ; Guerrerio AL; Dietz HC. 2011. Perturbation of thymocyte development in nonsense-mediated decay (NMD)-deficient mice. Proc Natl Acad Sci U S A 108(26):10638-43. [PubMed: 21670277]  [MGI Ref ID J:173551]

Gerard A; Khan O; Beemiller P; Oswald E; Hu J; Matloubian M; Krummel MF. 2013. Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8(+) T cells. Nat Immunol 14(4):356-63. [PubMed: 23475183]  [MGI Ref ID J:194908]

Gerbitz A; Sukumar M; Helm F; Wilke A; Friese C; Fahrenwaldt C; Lehmann FM; Loddenkemper C; Kammertoens T; Mautner J; Schmitt CA; Blankenstein T; Bornkamm GW. 2012. Stromal interferon-gamma signaling and cross-presentation are required to eliminate antigen-loss variants of B cell lymphomas in mice. PLoS One 7(3):e34552. [PubMed: 22479645]  [MGI Ref ID J:187120]

Graubert TA; DiPersio JF; Russell JH; Ley TJ. 1997. Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation. J Clin Invest 100(4):904-11. [PubMed: 9259590]  [MGI Ref ID J:42355]

Hammer GE; Gonzalez F; James E; Nolla H; Shastri N. 2007. In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides. Nat Immunol 8(1):101-8. [PubMed: 17128277]  [MGI Ref ID J:116606]

Hofling AA; Vogler C; Creer MH; Sands MS. 2003. Engraftment of human CD34+ cells leads to widespread distribution of donor-derived cells and correction of tissue pathology in a novel murine xenotransplantation model of lysosomal storage disease. Blood 101(5):2054-63. [PubMed: 12406886]  [MGI Ref ID J:109848]

Hogquist KA; Jameson SC; Heath WR; Howard JL; Bevan MJ; Carbone FR. 1994. T cell receptor antagonist peptides induce positive selection. Cell 76(1):17-27. [PubMed: 8287475]  [MGI Ref ID J:92867]

Huygen K; Drowart A; Harboe M; ten Berg R; Cogniaux J; Van Vooren JP. 1993. Influence of genes from the major histocompatibility complex on the antibody repertoire against culture filtrate antigens in mice infected with live Mycobacterium bovis BCG. Infect Immun 61(6):2687-93. [PubMed: 8500908]  [MGI Ref ID J:13022]

Jackson JT; Hu Y; Liu R; Masson F; D'Amico A; Carotta S; Xin A; Camilleri MJ; Mount AM; Kallies A; Wu L; Smyth GK; Nutt SL; Belz GT. 2011. Id2 expression delineates differential checkpoints in the genetic program of CD8alpha+ and CD103+ dendritic cell lineages. EMBO J 30(13):2690-704. [PubMed: 21587207]  [MGI Ref ID J:195908]

Kassiotis G; Garcia S; Simpson E; Stockinger B. 2002. Impairment of immunological memory in the absence of MHC despite survival of memory T cells. Nat Immunol 3(3):244-50. [PubMed: 11836529]  [MGI Ref ID J:151747]

Khanolkar A; Fulton RB; Epping LL; Pham NL; Tifrea D; Varga SM; Harty JT. 2010. T cell epitope specificity and pathogenesis of mouse hepatitis virus-1-induced disease in susceptible and resistant hosts. J Immunol 185(2):1132-41. [PubMed: 20554960]  [MGI Ref ID J:161935]

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Kirberg J; Bosco N; Deloulme JC; Ceredig R; Agenes F. 2008. Peripheral T lymphocytes recirculating back into the thymus can mediate thymocyte positive selection. J Immunol 181(2):1207-14. [PubMed: 18606674]  [MGI Ref ID J:137464]

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Klein J; Figueroa F; David CS. 1983. H-2 haplotypes, genes and antigens: second listing. II. The H-2 complex. Immunogenetics 17(6):553-96. [PubMed: 6407984]  [MGI Ref ID J:7097]

Koyama M; Kuns RD; Olver SD; Lineburg KE; Lor M; Teal BE; Raffelt NC; Leveque L; Chan CJ; Robb RJ; Markey KA; Alexander KA; Varelias A; Clouston AD; Smyth MJ; Macdonald KP; Hill GR. 2013. Promoting regulation via the inhibition of DNAM-1 after transplantation. Blood 121(17):3511-20. [PubMed: 23430112]  [MGI Ref ID J:196691]

Lamouse-Smith E; McCarthy SA. 1997. Allospecific cytotoxic T cells generated from beta 2m-/- mice in primary MLC: analysis of activation requirements, specificity, and phenotype. Cell Immunol 179(2):107-15. [PubMed: 9268494]  [MGI Ref ID J:42696]

Le Borgne M; Etchart N; Goubier A; Lira SA; Sirard JC; van Rooijen N; Caux C; Ait-Yahia S; Vicari A; Kaiserlian D; Dubois B. 2006. Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo. Immunity 24(2):191-201. [PubMed: 16473831]  [MGI Ref ID J:113330]

Leibnitz RR; Lipsky PE; Thiele DL. 1995. Protection from T helper cell-mediated graft-versus-host disease by the presence of an MHC class I alloantigen is associated with perturbation of MHC class II-restricted responses by class I-derived peptides. J Immunol 155(4):1784-95. [PubMed: 7636234]  [MGI Ref ID J:28656]

Li J; Heinrichs J; Leconte J; Haarberg K; Semple K; Liu C; Gigoux M; Kornete M; Piccirillo CA; Suh WK; Yu XZ. 2013. Phosphatidylinositol 3-kinase-independent signaling pathways contribute to ICOS-mediated T cell costimulation in acute graft-versus-host disease in mice. J Immunol 191(1):200-7. [PubMed: 23729441]  [MGI Ref ID J:205363]

Ljunggren HG; Van Kaer L; Sabatine MS; Auchincloss H Jr; Tonegawa S; Ploegh HL. 1995. MHC class I expression and CD8+ T cell development in TAP1/beta 2-microglobulin double mutant mice. Int Immunol 7(6):975-84. [PubMed: 7577806]  [MGI Ref ID J:26520]

Maeda Y; Reddy P; Lowler KP; Liu C; Bishop DK; Ferrara JL. 2005. Critical role of host gammadelta T cells in experimental acute graft-versus-host disease. Blood 106(2):749-55. [PubMed: 15797996]  [MGI Ref ID J:107458]

Matheoud D; Perie L; Hoeffel G; Vimeux L; Parent I; Maranon C; Bourdoncle P; Renia L; Prevost-Blondel A; Lucas B; Feuillet V; Hosmalin A. 2010. Cross-presentation by dendritic cells from live cells induces protective immune responses in vivo. Blood 115(22):4412-20. [PubMed: 20308597]  [MGI Ref ID J:161555]

McKenzie IF; Morgan GM; Blanden RV; Melvold R; Kohn H. 1977. Studies of H-2 mutations in C57BL/6 and BALB/c mice. Transplant Proc 9(1):551-3. [PubMed: 68588]  [MGI Ref ID J:109278]

McKenzie MD; Jamieson E; Jansen ES; Scott CL; Huang DC; Bouillet P; Allison J; Kay TW; Strasser A; Thomas HE. 2010. Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax. Diabetes 59(3):644-52. [PubMed: 19959756]  [MGI Ref ID J:164154]

Melvold RW; Wang K; Kohn HI. 1997. Histocompatibility gene mutation rates in the mouse: a 25-year review. Immunogenetics 47(1):44-54. [PubMed: 9382920]  [MGI Ref ID J:44711]

Meng XL; Shen JS; Kawagoe S; Ohashi T; Brady RO; Eto Y. 2010. Induced pluripotent stem cells derived from mouse models of lysosomal storage disorders. Proc Natl Acad Sci U S A 107(17):7886-91. [PubMed: 20385825]  [MGI Ref ID J:159373]

Miyada CG; Klofelt C; Reyes AA; McLaughlin-Taylor E; Wallace RB. 1985. Evidence that polymorphism in the murine major histocompatibility complex may be generated by the assortment of subgene sequences. Proc Natl Acad Sci U S A 82(9):2890-4. [PubMed: 2581256]  [MGI Ref ID J:109270]

Mohiuddin M; Ruggiero V; Shen Z; DiSesa VJ. 1996. T-cell receptor expression in C57BL/6 mice that reject or are rendered tolerant to bm1 cardiac grafts. J Thorac Cardiovasc Surg 112(2):310-3. [PubMed: 8751496]  [MGI Ref ID J:35731]

Newberg MH; Smith DH; Haertel SB; Vining DR; Lacy E; Engelhard VH. 1996. Importance of MHC class 1 alpha2 and alpha3 domains in the recognition of self and non-self MHC molecules. J Immunol 156(7):2473-80. [PubMed: 8786307]  [MGI Ref ID J:31937]

Nisizawa T; Ewenstein BM; Uehara H; McGovern D; Nathenson SG. 1981. Biochemical studies on the H-2K antigens of the MHC mutant bml. Immunogenetics 12(1-2):33-44. [PubMed: 6782017]  [MGI Ref ID J:164061]

Ohlemiller KK; Hennig AK; Lett JM; Heidbreder AF; Sands MS. 2002. Inner ear pathology in the mucopolysaccharidosis VII mouse. Hear Res 169(1-2):69-84. [PubMed: 12121741]  [MGI Ref ID J:108876]

Oracki SA; Tsantikos E; Quilici C; Light A; Schmidt T; Lew AM; Martin JE; Smith KG; Hibbs ML; Tarlinton DM. 2010. CTLA4Ig alters the course of autoimmune disease development in Lyn-/- mice. J Immunol 184(2):757-63. [PubMed: 19966213]  [MGI Ref ID J:159427]

Pease LR; Schulze DH; Pfaffenbach GM; Nathenson SG. 1983. Spontaneous H-2 mutants provide evidence that a copy mechanism analogous to gene conversion generates polymorphism in the major histocompatibility complex. Proc Natl Acad Sci U S A 80(1):242-6. [PubMed: 6571997]  [MGI Ref ID J:109263]

Prato S; Zhan Y; Mintern JD; Villadangos JA. 2013. Rapid deletion and inactivation of CTLs upon recognition of a number of target cells over a critical threshold. J Immunol 191(7):3534-44. [PubMed: 24018271]  [MGI Ref ID J:205935]

Robb RJ; Lineburg KE; Kuns RD; Wilson YA; Raffelt NC; Olver SD; Varelias A; Alexander KA; Teal BE; Sparwasser T; Hammerling GJ; Markey KA; Koyama M; Clouston AD; Engwerda CR; Hill GR; MacDonald KP. 2012. Identification and expansion of highly suppressive CD8(+)FoxP3(+) regulatory T cells after experimental allogeneic bone marrow transplantation. Blood 119(24):5898-908. [PubMed: 22538855]  [MGI Ref ID J:188644]

Rowe JH; Ertelt JM; Way SS. 2012. Innate IFN-gamma is essential for programmed death ligand-1-mediated T cell stimulation following Listeria monocytogenes infection. J Immunol 189(2):876-84. [PubMed: 22711893]  [MGI Ref ID J:189796]

Sancho D; Joffre OP; Keller AM; Rogers NC; Martinez D; Hernanz-Falcon P; Rosewell I; Reis e Sousa C. 2009. Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature 458(7240):899-903. [PubMed: 19219027]  [MGI Ref ID J:147472]

Sato T; Ikeda M; Yotsumoto S; Shimada Y; Higuchi T; Kobayashi H; Fukuda T; Ohashi T; Suda T; Ohteki T. 2013. Novel interferon-based pre-transplantation conditioning in the treatment of a congenital metabolic disorder. Blood 121(16):3267-73. [PubMed: 23412092]  [MGI Ref ID J:196707]

Schulze DH; Pease LR; Geier SS; Reyes AA; Sarmiento LA; Wallace RB; Nathenson SG. 1983. Comparison of the cloned H-2Kbm1 variant gene with the H-2Kb gene shows a cluster of seven nucleotide differences. Proc Natl Acad Sci U S A 80(7):2007-11. [PubMed: 6300887]  [MGI Ref ID J:109268]

Seillet C; Jackson JT; Markey KA; Brady HJ; Hill GR; Macdonald KP; Nutt SL; Belz GT. 2013. CD8alpha+ DCs can be induced in the absence of transcription factors Id2, Nfil3, and Batf3. Blood 121(9):1574-83. [PubMed: 23297132]  [MGI Ref ID J:194760]

Selvaggi G; Ricordi C; Podack ER; Inverardi L. 1996. The role of the perforin and Fas pathways of cytotoxicity in skin graft rejection. Transplantation 62(12):1912-5. [PubMed: 8990386]  [MGI Ref ID J:37400]

Semmling V; Lukacs-Kornek V; Thaiss CA; Quast T; Hochheiser K; Panzer U; Rossjohn J; Perlmutter P; Cao J; Godfrey DI; Savage PB; Knolle PA; Kolanus W; Forster I; Kurts C. 2010. Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs. Nat Immunol 11(4):313-20. [PubMed: 20190758]  [MGI Ref ID J:158986]

Serody JS; Burkett SE; Panoskaltsis-Mortari A; Ng-Cashin J; McMahon E; Matsushima GK; Lira SA; Cook DN; Blazar BR. 2000. T-lymphocyte production of macrophage inflammatory protein-1alpha is critical to the recruitment of CD8(+) T cells to the liver, lung, and spleen during graft-versus-host disease Blood 96(9):2973-80. [PubMed: 11049973]  [MGI Ref ID J:65501]

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Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

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Cryopreserved

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Cryorecovery* $2140.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

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Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

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  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

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Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2782.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

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  • View the complete collection of spontaneous mutants in the Mouse Mutant Resource.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

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MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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