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| When these HB9cre mice are bred with mice containing a loxP-flanked sequence of interest, Cre-mediated recombination in the resulting offspring leads to deletion of the flanked sequences in Mnx1/HB9 expressing cells; making them useful in neurodevelopmental studies of homeobox genes, motor neuron function and differentiation, and the central nervous system. | |||||||||||||||||||
- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
- Terms of use
Description
Strain Information
Former Names B6;129S-Mnx1tm4(cre)Tmj/J (Changed: 07-SEP-07 ) B6;129S-Hlxb9tm4(cre)Tmj/J (Changed: 17-AUG-07 ) Type Congenic; Mutant Stock; Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System +/+ sibling x Heterozygote (Female x Male) 19-OCT-07 Species laboratory mouse Generation N?+N5F7 (02-MAY-11)
Generation DefinitionsDonating Investigator Thomas M. Jessell, Columbia University/HHMI Description
Mice heterozygous for this HB9cre targeted mutation are viable and fertile, with cre expression replacing HB9 (Hlxb9 or Mnx1) expression. Under control of the endogenous upstream elements, cre expression is directed to motor neurons. In heterozygotes, cre expression coincides with HB9 expression. Homozygous HB9cre mice die at or soon after birth, with expression of Cre recombinase likewise directed to motor neurons but no expression of endogenous HB9. When these HB9cre mice are bred with mice containing a loxP-flanked sequence of interest, Cre-mediated recombination in the resulting offspring leads to deletion of the flanked sequences in Mnx1/HB9 expressing cells; making them useful in neurodevelopmental studies of homeobox genes, motor neuron function and differentiation, and the central nervous system.View cre expression characterization.
Development
A targeting vector containing an internal ribosome entry site (IRES)-Cre cassette, SV40 polyA sequence, and loxP-flanked pgk-neo cassette was designed to replace a portion of the first exon of the targeted gene. The construct was electroporated into 129S1/Sv-derived W9.5 embryonic stem (ES) cells. Recombinant clones were injected into C57BL/6J blastocysts to generate chimeric founders that transmitted the mutant allele. These HB9cre mice were then backcrossed for at least 5 generations prior to arrival at The Jackson Laboratory.
Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Mnx1tm4(cre)Tmj allele
007022 STOCK Mnx1tm4(cre)Tmj Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb Tg(SMN2)89Ahmb/J View Strains carrying Mnx1tm4(cre)Tmj (1 strain)
005029 B6.Cg-Tg(Hlxb9-GFP)1Tmj/J 017953 B6;C-Tg(Mnx1-Gfra1)1Slp/J 010928 STOCK Mnx1tm1Spf/J 006570 STOCK Smn1tm1Msd Tg(Hlxb9-GFP)1Tmj Tg(SMN2)89Ahmb/J
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested. Currarino Syndrome (MNX1)
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Mnx1tm4(cre)Tmj/Mnx1+
involves: 129S1/Sv
- muscle phenotype
- decreased skeletal muscle fiber size
- compared with Gt(ROSA)26Sortm1(CAG-PLS3,-GFP)Bwir heterozygotes (MGI Ref ID J:193844)
- nervous system phenotype
- abnormal neuromuscular synapse morphology
- mice exhibit reduced endplate size compared with Gt(ROSA)26Sortm1(CAG-PLS3,-GFP)Bwir heterozygotes (MGI Ref ID J:193844)
This mouse can be used to support research in many areas including:
cre relatedDevelopmental Biology Research
Neurodevelopmental Defects
Perinatal Lethality
Homozygous
Neurobiology Research
Cre-lox System
Cre Recombinase expression in neural tissue
Neurodevelopmental Defects
Research Tools
Cre-lox System
Cre Recombinase Expression
Developmental Biology Research
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Tissue/Cell Markers
Tissue/Cell Markers: Cre-lox System
Neurobiology Research
cell marker
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Mnx1tm4(cre)Tmj | ||
|---|---|---|---|
| Allele Name | targeted mutation 4, Thomas M Jessell | ||
| Allele Type | Targeted (knock-in) | ||
| Common Name(s) | HB9Cre; Hb9-CRE; Hlxb9tm4(cre)Tmj; | ||
| Mutation Made By | Thomas Jessell, Columbia University/HHMI | ||
| Strain of Origin | 129S1/Sv-Oca2<+> Tyr<+> Kitl<+> | ||
| ES Cell Line Name | W9.5/W95 | ||
| ES Cell Line Strain | 129S1/Sv-Oca2<+> Tyr<+> Kitl<+> | ||
| Site of Expression | motor neurons | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Driver Note | Mnx1 | ||
| Molecular Note | Exon 1 was disrupted by the insertion of a cassette containing an IRES-tau-cre gene, a floxed neomycin gene, and a SV40 polyadenylation signal. [MGI Ref ID J:69623] | ||
| Gene Symbol and Name | Mnx1, motor neuron and pancreas homeobox 1 | ||
| Chromosome | 5 | ||
| Gene Common Name(s) | HB9; HLXB9; HOXHB9; Hlxb9; MNR2; SCRA1; homeobox gene HB9; | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre Melt Curve Analysis, Melt Curve Analysis
Generic Cre, Standard PCR
Mnx1tm4(cre)Tmj, Separated PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Arber S; Han B; Mendelsohn M; Smith M; Jessell TM; Sockanathan S. 1999. Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity [see comments] Neuron 23(4):659-74. [PubMed: 10482234] [MGI Ref ID J:57340]
Yang X; Arber S; William C; Li L; Tanabe Y; Jessell TM; Birchmeier C; Burden SJ. 2001. Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation. Neuron 30(2):399-410. [PubMed: 11395002] [MGI Ref ID J:69623]
Additional References
Mnx1tm4(cre)Tmj relatedAckermann B; Krober S; Torres-Benito L; Borgmann A; Peters M; Hosseini Barkooie SM; Tejero R; Jakubik M; Schreml J; Milbradt J; Wunderlich TF; Riessland M; Tabares L; Wirth B. 2013. Plastin 3 ameliorates spinal muscular atrophy via delayed axon pruning and improves neuromuscular junction functionality. Hum Mol Genet 22(7):1328-47. [PubMed: 23263861] [MGI Ref ID J:193844]
Bloom AJ; Miller BR; Sanes JR; Diantonio A. 2007. The requirement for Phr1 in CNS axon tract formation reveals the corticostriatal boundary as a choice point for cortical axons. Genes Dev 21(20):2593-606. [PubMed: 17901218] [MGI Ref ID J:125702]
Bolis A; Coviello S; Bussini S; Dina G; Pardini C; Previtali SC; Malaguti M; Morana P; Del Carro U; Feltri ML; Quattrini A; Wrabetz L; Bolino A. 2005. Loss of Mtmr2 phosphatase in Schwann cells but not in motor neurons causes Charcot-Marie-Tooth type 4B1 neuropathy with myelin outfoldings. J Neurosci 25(37):8567-77. [PubMed: 16162938] [MGI Ref ID J:101056]
Bolliger MF; Zurlinden A; Luscher D; Butikofer L; Shakhova O; Francolini M; Kozlov SV; Cinelli P; Stephan A; Kistler AD; Rulicke T; Pelczar P; Ledermann B; Fumagalli G; Gloor SM; Kunz B; Sonderegger P. 2010. Specific proteolytic cleavage of agrin regulates maturation of the neuromuscular junction. J Cell Sci 123(Pt 22):3944-55. [PubMed: 20980386] [MGI Ref ID J:182912]
Cheever TR; Olson EA; Ervasti JM. 2011. Axonal regeneration and neuronal function are preserved in motor neurons lacking ss-actin in vivo. PLoS One 6(3):e17768. [PubMed: 21445349] [MGI Ref ID J:171672]
Chen F; Liu Y; Sugiura Y; Allen PD; Gregg RG; Lin W. 2011. Neuromuscular synaptic patterning requires the function of skeletal muscle dihydropyridine receptors. Nat Neurosci 14(5):570-7. [PubMed: 21441923] [MGI Ref ID J:172291]
Chipman PH; Franz CK; Nelson A; Schachner M; Rafuse VF. 2010. Neural cell adhesion molecule is required for stability of reinnervated neuromuscular junctions. Eur J Neurosci 31(2):238-49. [PubMed: 20074227] [MGI Ref ID J:158382]
Genetic Resource Sciences at The Jackson Laboratory. 2012. Expression/Specificity Patterns of Cre Alleles, 2011 MGI Direct Data Submission :. [MGI Ref ID J:184578]
Gogliotti RG; Quinlan KA; Barlow CB; Heier CR; Heckman CJ; Didonato CJ. 2012. Motor neuron rescue in spinal muscular atrophy mice demonstrates that sensory-motor defects are a consequence, not a cause, of motor neuron dysfunction. J Neurosci 32(11):3818-29. [PubMed: 22423102] [MGI Ref ID J:183080]
Gould TW; Yonemura S; Oppenheim RW; Ohmori S; Enomoto H. 2008. The neurotrophic effects of glial cell line-derived neurotrophic factor on spinal motoneurons are restricted to fusimotor subtypes. J Neurosci 28(9):2131-46. [PubMed: 18305247] [MGI Ref ID J:132854]
Hippenmeyer S; Huber RM; Ladle DR; Murphy K; Arber S. 2007. ETS transcription factor Erm controls subsynaptic gene expression in skeletal muscles. Neuron 55(5):726-40. [PubMed: 17785180] [MGI Ref ID J:126807]
Hippenmeyer S; Vrieseling E; Sigrist M; Portmann T; Laengle C; Ladle DR; Arber S. 2005. A developmental switch in the response of DRG neurons to ETS transcription factor signaling. PLoS Biol 3(5):e159. [PubMed: 15836427] [MGI Ref ID J:100886]
Horn M; Baumann R; Pereira JA; Sidiropoulos PN; Somandin C; Welzl H; Stendel C; Luhmann T; Wessig C; Toyka KV; Relvas JB; Senderek J; Suter U. 2012. Myelin is dependent on the Charcot-Marie-Tooth Type 4H disease culprit protein FRABIN/FGD4 in Schwann cells. Brain 135(Pt 12):3567-83. [PubMed: 23171661] [MGI Ref ID J:190437]
Ivanova E; Hwang GS; Pan ZH. 2010. Characterization of transgenic mouse lines expressing Cre recombinase in the retina. Neuroscience 165(1):233-43. [PubMed: 19837136] [MGI Ref ID J:158209]
Jevsek M; Jaworski A; Polo-Parada L; Kim N; Fan J; Landmesser LT; Burden SJ. 2006. CD24 is expressed by myofiber synaptic nuclei and regulates synaptic transmission. Proc Natl Acad Sci U S A 103(16):6374-9. [PubMed: 16606832] [MGI Ref ID J:109028]
Kim N; Burden SJ. 2008. MuSK controls where motor axons grow and form synapses. Nat Neurosci 11(1):19-27. [PubMed: 18084289] [MGI Ref ID J:129239]
Kramer ER; Knott L; Su F; Dessaud E; Krull CE; Helmbacher F; Klein R. 2006. Cooperation between GDNF/Ret and ephrinA/EphA4 signals for motor-axon pathway selection in the limb. Neuron 50(1):35-47. [PubMed: 16600854] [MGI Ref ID J:110955]
La Marca R; Cerri F; Horiuchi K; Bachi A; Feltri ML; Wrabetz L; Blobel CP; Quattrini A; Salzer JL; Taveggia C. 2011. TACE (ADAM17) inhibits Schwann cell myelination. Nat Neurosci 14(7):857-65. [PubMed: 21666671] [MGI Ref ID J:174007]
Li XM; Dong XP; Luo SW; Zhang B; Lee DH; Ting AK; Neiswender H; Kim CH; Carpenter-Hyland E; Gao TM; Xiong WC; Mei L. 2008. Retrograde regulation of motoneuron differentiation by muscle beta-catenin. Nat Neurosci 11(3):262-8. [PubMed: 18278041] [MGI Ref ID J:135587]
Liu Y; Sugiura Y; Wu F; Mi W; Taketo MM; Cannon S; Carroll T; Lin W. 2012. beta-Catenin stabilization in skeletal muscles, but not in motor neurons, leads to aberrant motor innervation of the muscle during neuromuscular development in mice. Dev Biol 366(2):255-67. [PubMed: 22537499] [MGI Ref ID J:185422]
Luria V; Laufer E. 2007. Lateral motor column axons execute a ternary trajectory choice between limb and body tissues. Neural Dev 2:13. [PubMed: 17605791] [MGI Ref ID J:160874]
Mende Y; Jakubik M; Riessland M; Schoenen F; Rossbach K; Kleinridders A; Kohler C; Buch T; Wirth B. 2010. Deficiency of the splicing factor Sfrs10 results in early embryonic lethality in mice and has no impact on full-length SMN/Smn splicing. Hum Mol Genet 19(11):2154-67. [PubMed: 20190275] [MGI Ref ID J:159448]
Patel TD; Kramer I; Kucera J; Niederkofler V; Jessell TM; Arber S; Snider WD. 2003. Peripheral NT3 signaling is required for ETS protein expression and central patterning of proprioceptive sensory afferents. Neuron 38(3):403-16. [PubMed: 12741988] [MGI Ref ID J:83461]
Prasad T; Weiner JA. 2011. Direct and Indirect Regulation of Spinal Cord Ia Afferent Terminal Formation by the gamma-Protocadherins. Front Mol Neurosci 4:54. [PubMed: 22275881] [MGI Ref ID J:190261]
Pun S; Sigrist M; Santos AF; Ruegg MA; Sanes JR; Jessell TM; Arber S; Caroni P. 2002. An intrinsic distinction in neuromuscular junction assembly and maintenance in different skeletal muscles. Neuron 34(3):357-70. [PubMed: 11988168] [MGI Ref ID J:76364]
Wu H; Lu Y; Barik A; Joseph A; Taketo MM; Xiong WC; Mei L. 2012. beta-Catenin gain of function in muscles impairs neuromuscular junction formation. Development 139(13):2392-404. [PubMed: 22627288] [MGI Ref ID J:185531]
Wu H; Lu Y; Shen C; Patel N; Gan L; Xiong WC; Mei L. 2012. Distinct roles of muscle and motoneuron LRP4 in neuromuscular junction formation. Neuron 75(1):94-107. [PubMed: 22794264] [MGI Ref ID J:188352]
Wu LS; Cheng WC; Shen CK. 2012. Targeted depletion of TDP-43 expression in the spinal cord motor neurons leads to the development of amyotrophic lateral sclerosis-like phenotypes in mice. J Biol Chem 287(33):27335-44. [PubMed: 22718760] [MGI Ref ID J:190254]
Zhang L; Schessl J; Werner M; Bonnemann C; Xiong G; Mojsilovic-Petrovic J; Zhou W; Cohen A; Seeburg P; Misawa H; Jayaram A; Personius K; Hollmann M; Sprengel R; Kalb R. 2008. Role of GluR1 in activity-dependent motor system development. J Neurosci 28(40):9953-68. [PubMed: 18829953] [MGI Ref ID J:141815]
Zhou W; Zhang L; Guoxiang X; Mojsilovic-Petrovic J; Takamaya K; Sattler R; Huganir R; Kalb R. 2008. GluR1 controls dendrite growth through its binding partner, SAP97. J Neurosci 28(41):10220-33. [PubMed: 18842882] [MGI Ref ID J:141127]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX12
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, heterozygous mice may be bred to wildtype siblings or to C57BL/6J. Mating System +/+ sibling x Heterozygote (Female x Male) 19-OCT-07 Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $232.00 Female or Male Heterozygous for Mnx1tm4(cre)Tmj
Price per Pair (US dollars $) Pair Genotype $296.00 Heterozygous for Mnx1tm4(cre)Tmj x Wild-type for Mnx1tm4(cre)Tmj $296.00 Wild-type for Mnx1tm4(cre)Tmj x Heterozygous for Mnx1tm4(cre)Tmj Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $301.60 Female or Male Heterozygous for Mnx1tm4(cre)Tmj
Price per Pair (US dollars $) Pair Genotype $384.80 Heterozygous for Mnx1tm4(cre)Tmj x Wild-type for Mnx1tm4(cre)Tmj $384.80 Wild-type for Mnx1tm4(cre)Tmj x Heterozygous for Mnx1tm4(cre)Tmj Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
|
|
|
Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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| phone: | 207-288-6470 |
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